Reference on EC 3.4.24.82 - ADAMTS-4 endopeptidase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hughes, C.E.; Buttner, F.H.; Eidenmuller, B.; Caterson, B.; Bartnik, E.
Utilization of a recombinant substrate rAgg1 to study the biochemical properties of aggrecanase in cell culture systems
J. Biol. Chem.
272
20269-20274
1997
Bos taurus, Rattus norvegicus
Little, C.B.; Flannery, C.R.; Hughes, C.E.; Mort, J.S.; Roughley, P.J.; Dent, C.; Caterson, B.
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro
Biochem. J.
344
61-68
1999
Bos taurus, Homo sapiens, Sus scrofa
-
Sugimoto, K.; Takahashi, M.; Yamamoto, Y.; Shimada, K.; Tanzawa, K.
Identification of aggrecanase activity in medium of cartilage culture
J. Biochem.
126
449-455
1999
Bos taurus
Tortorella, M.D.; Burn, T.C.; Pratta, M.A.; Abbaszade, I.; Hollis, J.M.; Liu, R.; Rosenfeld, S.A.; Copeland, R.A.; Decicco, C.P.; Wynn, R.; Rockwell, A.; Yang, F.; Duke, J.L.; Solomon, K.; George, H.; Bruckner, R.; Nagase, H.; Itoh, Y.; Ellis, D.M.; Ross, H.; Wiswall, B.H.; Murphy, K.; Hillman, M.C., Jr.; Hollis, G.F.; Arner, E.C.; et al.
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins
Science
284
1664-1666
1999
Bos taurus, Homo sapiens (O75173)
Nakamura, H.; Fujii, Y.; Inoki, I.; Sugimoto, K.; Tanzawa, K.; Matsuki, H.; Miura, R.; Yamaguchi, Y.; Okada, Y.
Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites
J. Biol. Chem.
275
38885-38890
2000
Homo sapiens (O75173)
Tortorella, M.D.; Pratta, M.; Liu, R.Q.; Austin, J.; Ross, O.H.; Abbaszade, I.; Burn, T.; Arner, E.
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)
J. Biol. Chem.
275
18566-18573
2000
Bos taurus, Homo sapiens (O75173), Homo sapiens
Tortorella, M.; Pratta, M.; Liu, R.Q.; Abbaszade, I.; Ross, H.; Burn, T.; Arner, E.
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage
J. Biol. Chem.
275
25791-25797
2000
Homo sapiens (O75173), Homo sapiens
Satoh, K.; Suzuki, N.; Yokota, H.
ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs) is transcriptionally induced in beta-amyloid treated rat astrocytes
Neurosci. Lett.
289
177-180
2000
Rattus norvegicus (Q9ESP7)
Sandy, J.D.; Westling, J.; Kenagy, R.D.; Iruela-Arispe, M.L.; Verscharen, C.; Rodriguez-Mazaneque, J.C.; Zimmermann, D.R.; Lemire, J.M.; Fischer, J.W.; Wight, T.N.; Clowes, A.W.
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4
J. Biol. Chem.
276
13372-13378
2001
Homo sapiens, Homo sapiens (O75173)
Bluteau, G.; Conrozier, T.; Mathieu, P.; Vignon, E.; Herbage, D.; Mallein-Gerin, F.
Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis
Biochim. Biophys. Acta
1526
147-158
2001
Oryctolagus cuniculus (Q9GLK6), Oryctolagus cuniculus (Q9GLK7), Oryctolagus cuniculus
Flannery, C.R.; Zeng, W.; Corcoran, C.; Collins-Racie, L.A.; Chockalingam, P.S.; Hebert, T.; Mackie, S.A.; McDonagh, T.; Crawford, T.K.; Tomkinson, K.N.; LaVallie, E.R.; Morris, E.A.
Autocatalytic cleavage of ADAMTS-4 (aggrecanase-1) reveals multiple glycosaminoglycan-binding sites
J. Biol. Chem.
277
42775-42780
2002
Homo sapiens (O75173)
Westling, J.; Fosang, A.J.; Last, K.; Thompson, V.P.; Tomkinson, K.N.; Hebert, T.; McDonagh, T.; Collins-Racie, L.A.; LaVallie, E.R.; Morris, E.A.; Sandy, J.D.
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain
J. Biol. Chem.
277
16059-16066
2002
Homo sapiens, Homo sapiens (O75173)
Gao, G.; Westling, J.; Thompson, V.P.; Howell, T.D.; Gottschall, P.E.; Sandy, J.D.
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation
J. Biol. Chem.
277
11034-11041
2002
Homo sapiens, Homo sapiens (O75173), Sus scrofa
Tortorella, M.D.; Liu, R.Q.; Burn, T.; Newton, R.C.; Arner, E.
Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4)
Matrix Biol.
21
499-511
2002
Homo sapiens, Homo sapiens (O75173)
Miller, J.A.; Liu, R.Q.; Davis, G.L.; Pratta, M.A.; Trzaskos, J.M.; Copeland, R.A.
A microplate assay specific for the enzyme aggrecanase
Anal. Biochem.
314
260-265
2003
Bos taurus
Tortorella, M.D.; Arner, E.C.; Hills, R.; Gormley, J.; Fok, K.; Pegg, L.; Munie, G.; Malfait, A.M.
ADAMTS-4 (aggrecanase-1): N-terminal activation mechanisms
Arch. Biochem. Biophys.
444
34-44
2005
Bos taurus
Chockalingam, P.S.; Zeng, W.; Morris, E.A.; Flannery, C.R.
Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2)
Arthritis Rheum.
50
2839-2848
2004
Homo sapiens
Behera, A.K.; Hildebrand, E.; Szafranski, J.; Hung, H.H.; Grodzinsky, A.J.; Lafyatis, R.; Koch, A.E.; Kalish, R.; Perides, G.; Steere, A.C.; Hu, L.T.
Role of aggrecanase 1 in Lyme arthritis
Arthritis Rheum.
54
3319-3329
2006
Bos taurus, Homo sapiens, Mus musculus, Mus musculus C3H/HEN
Liacini, A.; Sylvester, J.; Zafarullah, M.
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes
Biochem. Biophys. Res. Commun.
327
320-327
2005
Homo sapiens
Westling, J.; Gottschall, P.E.; Thompson, V.P.; Cockburn, A.; Perides, G.; Zimmermann, D.R.; Sandy, J.D.
ADAMTS4 (aggrecanase-1) cleaves human brain versican V2 at Glu405-Gln406 to generate glial hyaluronate binding protein
Biochem. J.
377
787-795
2004
Homo sapiens
Yoshida, K.; Suzuki, Y.; Saito, A.; Fukuda, K.; Hamanishi, C.; Munakata, H.
Aggrecanase-1 (ADAMTS-4) interacts with a1-antitrypsin
Biochim. Biophys. Acta
1725
152-159
2005
Homo sapiens
Miwa, H.E.; Gerken, T.A.; Huynh, T.D.; Flory, D.M.; Hering, T.M.
Mammalian expression of full-length bovine aggrecan and link protein: Formation of recombinant proteoglycan aggregates and analysis of proteolytic cleavage by ADAMTS-4 and MMP-13
Biochim. Biophys. Acta
1760
472-486
2006
Homo sapiens
Noe, M.C.; Natarajan, V.; Snow, S.L.; Mitchell, P.G.; Lopresti-Morrow, L.; Reeves, L.M.; Yocum, S.A.; Carty, T.J.; Barberia, J.A.; Sweeney, F.J.; Liras, J.L.; Vaughn, M.; Hardink, J.R.; Hawkins, J.M.; Tokar, C.
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13
Bioorg. Med. Chem. Lett.
15
2808-2811
2005
Homo sapiens
Xiang, J.S.; Hu, Y.; Rush, T.S.; Thomason, J.R.; Ipek, M.; Sum, P.E.; Abrous, L.; Sabatini, J.J.; Georgiadis, K.; Reifenberg, E.; Majumdar, M.; Morris, E.A.; Tam, S.
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors
Bioorg. Med. Chem. Lett.
16
311-316
2006
Rattus norvegicus
Cross, A.K.; Haddock, G.; Stock, C.J.; Allan, S.; Surr, J.; Bunning, R.A.; Buttle, D.J.; Woodroofe, M.N.
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes
Brain Res.
1088
19-30
2006
Homo sapiens, Rattus norvegicus
Liu, R.; Trzaskos, J.M.
Aggrecanase: The family and its inhibitors
Curr. Med. Chem. Anti-Inflamm. Anti-Allergy
4
251-264
2005
Bos taurus
-
Held-Feindt, J.; Paredes, E.B.; Bloemer, U.; Seidenbecher, C.; Stark, A.M.; Mehdorn, H.M.; Mentlein, R.
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas
Int. J. Cancer
118
55-61
2005
Homo sapiens
Cross, A.K.; Haddock, G.; Surr, J.; Plumb, J.; Bunning, R.A.; Buttle, D.J.; Woodroofe, M.N.
Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis
J. Autoimmun.
26
16-23
2006
Rattus norvegicus
Gao, G.; Plaas, A.; Thompson, V.P.; Jin, S.; Zuo, F.; Sandy, J.D.
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1
J. Biol. Chem.
279
10042-10051
2004
Homo sapiens
Kashiwagi, M.; Enghild, J.J.; Gendron, C.; Hughes, C.; Caterson, B.; Itoh, Y.; Nagase, H.
Altered Proteolytic Activities of ADAMTS-4 Expressed by C-terminal Processing
J. Biol. Chem.
279
10109-10119
2004
Sus scrofa
Hashimoto, G.; Shimoda, M.; Okada, Y.
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan
J. Biol. Chem.
279
32483-32491
2004
Bos taurus
Wainwright, S.D.; Bondeson, J.; Hughes, C.E.
An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients
Matrix Biol.
25
317-320
2006
Homo sapiens
Cross, N.A.; Chandrasekharan, S.; Jokonya, N.; Fowles, A.; Hamdy, F.C.; Buttle, D.J.; Eaton, C.L.
The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican
Prostate
63
269-275
2005
Homo sapiens
Song, R.H.; Tortorella, M.D.; Malfait, A.M.; Alston, J.T.; Yang, Z.; Arner, E.C.; Griggs, D.W.
Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5
Arthritis Rheum.
56
575-585
2007
Homo sapiens
Wagsaeter, D.; Bjoerk, H.; Zhu, C.; Bjoerkegren, J.; Valen, G.; Hamsten, A.; Eriksson, P.
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques
Atherosclerosis
196
514-522
2008
Homo sapiens
Wittwer, A.J.; Hills, R.L.; Keith, R.H.; Munie, G.E.; Arner, E.C.; Anglin, C.P.; Malfait, A.M.; Tortorella, M.D.
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (aggrecanase 1)
Biochemistry
46
6393-6401
2007
Mus musculus
El Mabrouk, M.; Sylvester, J.; Zafarullah, M.
Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes
Biochim. Biophys. Acta
1773
309-320
2007
Homo sapiens
Bondeson, J.; Wainwright, S.; Hughes, C.; Caterson, B.
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review
Clin. Exp. Rheumatol.
26
139-145
2008
Bos taurus, Homo sapiens, Mus musculus, Sus scrofa
Hills, R.; Mazzarella, R.; Fok, K.; Liu, M.; Nemirovskiy, O.; Leone, J.; Zack, M.D.; Arner, E.C.; Viswanathan, M.; Abujoub, A.; Muruganandam, A.; Sexton, D.J.; Bassill, G.J.; Sato, A.K.; Malfait, A.M.; Tortorella, M.D.
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate
J. Biol. Chem.
282
11101-11109
2007
Homo sapiens
Lauer-Fields, J.L.; Minond, D.; Sritharan, T.; Kashiwagi, M.; Nagase, H.; Fields, G.B.
Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases
J. Biol. Chem.
282
142-150
2007
Homo sapiens
Gendron, C.; Kashiwagi, M.; Lim, N.H.; Enghild, J.J.; Thogersen, I.B.; Hughes, C.; Caterson, B.; Nagase, H.
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4
J. Biol. Chem.
282
18294-18306
2007
Homo sapiens
Wayne, G.J.; Deng, S.J.; Amour, A.; Borman, S.; Matico, R.; Carter, H.L.; Murphy, G.
TIMP-3 inhibition of ADAMTS-4 (aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4
J. Biol. Chem.
282
20991-20998
2007
Homo sapiens
Fushimi, K.; Troeberg, L.; Nakamura, H.; Lim, N.H.; Nagase, H.
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
J. Biol. Chem.
283
6706-6716
2008
Homo sapiens
Mosyak, L.; Georgiadis, K.; Shane, T.; Svenson, K.; Hebert, T.; McDonagh, T.; Mackie, S.; Olland, S.; Lin, L.; Zhong, X.; Kriz, R.; Reifenberg, E.L.; Collins-Racie, L.A.; Corcoran, C.; Freeman, B.; Zollner, R.; Marvell, T.; Vera, M.; Sum, P.E.; Lavallie, E.R.; Stahl, M.; Somers, W.
Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
Protein Sci.
17
16-21
2008
Homo sapiens
Wang, Z.H.; Yang, Z.Q.; He, X.J.; Wang, L.; Li, L.X.; Tu, J.B.
Effects of RNAi-mediated inhibition of aggrecanase-1 and aggrecanase-2 on rat costochondral chondrocytes in vitro
Acta Pharmacol. Sin.
29
1215-1226
2008
Rattus norvegicus (Q9ESP7)
Yatabe, T.; Mochizuki, S.; Takizawa, M.; Chijiiwa, M.; Okada, A.; Kimura, T.; Fujita, Y.; Matsumoto, H.; Toyama, Y.; Okada, Y.
Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes
Ann. Rheum. Dis.
68
1051-1058
2009
Homo sapiens
Rogerson, F.M.; Stanton, H.; East, C.J.; Golub, S.B.; Tutolo, L.; Farmer, P.J.; Fosang, A.J.
Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5
Arthritis Rheum.
58
1664-1673
2008
Mus musculus
Pockert, A.J.; Richardson, S.M.; Le Maitre, C.L.; Lyon, M.; Deakin, J.A.; Buttle, D.J.; Freemont, A.J.; Hoyland, J.A.
Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration
Arthritis Rheum.
60
482-491
2009
Homo sapiens
Miwa, H.E.; Gerken, T.A.; Huynh, T.D.; Duesler, L.R.; Cotter, M.; Hering, T.M.
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5
Biochim. Biophys. Acta
1790
161-172
2009
Homo sapiens
Hopper, D.W.; Vera, M.D.; How, D.; Sabatini, J.; Xiang, J.S.; Ipek, M.; Thomason, J.; Hu, Y.; Feyfant, E.; Wang, Q.; Georgiadis, K.E.; Reifenberg, E.; Sheldon, R.T.; Keohan, C.C.; Majumdar, M.K.; Morris, E.A.; Skotnicki, J.; Sum, P.E.
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors
Bioorg. Med. Chem. Lett.
19
2487-2491
2009
Mus musculus (Q8BNJ2)
Hamel, M.G.; Ajmo, J.M.; Leonardo, C.C.; Zuo, F.; Sandy, J.D.; Gottschall, P.E.
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
Exp. Neurol.
210
428-440
2008
Homo sapiens (O75173)
Takizawa, M.; Yatabe, T.; Okada, A.; Chijiiwa, M.; Mochizuki, S.; Ghosh, P.; Okada, Y.
Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes
FEBS Lett.
582
2945-2949
2008
Homo sapiens
Demircan, K.; Gunduz, E.; Gunduz, M.; Beder, L.B.; Hirohata, S.; Nagatsuka, H.; Cengiz, B.; Cilek, M.Z.; Yamanaka, N.; Shimizu, K.; Ninomiya, Y.
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer
Head Neck
10
793-801
2009
Homo sapiens
Ahmad, R.; Sylvester, J.; Ahmad, M.; Zafarullah, M.
Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes
J. Immunol.
182
5081-5087
2009
Homo sapiens
Frank, J.E.; Thompson, V.P.; Brown, M.P.; Sandy, J.D.
Removal of O-linked and N-linked oligosaccharides is required for optimum detection of NITEGE neoepitope on ADAMTS4-digested fetal aggrecans: implications for specific N-linked glycan-dependent aggrecanolysis at Glu373-Ala374
Osteoarthritis Cartilage
17
777-781
2008
Homo sapiens (O75173), Homo sapiens
Cheung, K.S.; Hashimoto, K.; Yamada, N.; Roach, H.I.
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation
Rheumatol. Int.
29
525-534
2009
Homo sapiens (O75173), Homo sapiens
Willems, S.H.; Tape, C.J.; Stanley, P.L.; Taylor, N.A.; Mills, I.G.; Neal, D.E.; McCafferty, J.; Murphy, G.
Thiol isomerases negatively regulate the cellular shedding activity of ADAM17
Biochem. J.
428
439-450
2010
Homo sapiens
Lim, N.H.; Kashiwagi, M.; Visse, R.; Jones, J.; Enghild, J.J.; Brew, K.; Nagase, H.
Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications
Biochem. J.
431
113-122
2010
Homo sapiens
Zha, Y.; Chen, Y.; Xu, F.; Li, T.; Zhao, C.; Cui, L.
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes
Biomed. Pharmacother.
64
160-164
2010
Homo sapiens
Cudic, M.; Burstein, G.D.; Fields, G.B.; Lauer-Fields, J.
Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates
Chem. Biol. Drug Des.
74
473-482
2009
Sus scrofa
Cappelli, A.; Nannicini, C.; Valenti, S.; Giuliani, G.; Anzini, M.; Mennuni, L.; Giordani, A.; Caselli, G.; Stasi, L.P.; Makovec, F.; Giorgi, G.; Vomero, S.
Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors
ChemMedChem
5
739-748
2010
Homo sapiens
Tortorella, M.D.; Tomasselli, A.G.; Mathis, K.J.; Schnute, M.E.; Woodard, S.S.; Munie, G.; Williams, J.M.; Caspers, N.; Wittwer, A.J.; Malfait, A.M.; Shieh, H.S.
Structural and inhibition analysis reveals the mechanism of selectivity of a series of aggrecanase inhibitors
J. Biol. Chem.
284
24185-24191
2009
Homo sapiens
Weaver, M.S.; Workman, G.; Cardo-Vila, M.; Arap, W.; Pasqualini, R.; Sage, E.H.
Processing of the matricellular protein hevin in mouse brain is dependent on ADAMTS4
J. Biol. Chem.
285
5868-5877
2010
Mus musculus
Steinmeyer, J.; Kordelle, J.; Stuerz, H.
In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage
J. Orthop. Res.
28
828-833
2010
Homo sapiens
Troeberg, L.; Fushimi, K.; Scilabra, S.D.; Nakamura, H.; Dive, V.; Thogersen, I.B.; Enghild, J.J.; Nagase, H.
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
Matrix Biol.
28
463-469
2009
Homo sapiens
Hu, Y.; Xing, L.; Thomason, J.R.; Xiang, J.; Ipek, M.; Guler, S.; Li, H.; Sabatini, J.; Chockalingam, P.; Reifenberg, E.; Sheldon, R.; Morris, E.A.; Georgiadis, K.E.; Tam, S.
Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition
Bioorg. Med. Chem. Lett.
21
6800-6803
2011
Homo sapiens
Hsu, Y.P.; Staton, C.A.; Cross, N.; Buttle, D.J.
Anti-angiogenic properties of ADAMTS-4 in vitro
Int. J. Exp. Pathol.
93
70-77
2012
Homo sapiens
Verma, P.; Dalal, K.
ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis
J. Cell. Biochem.
112
3507-3514
2011
Homo sapiens
Ariyoshi, W.; Takahashi, N.; Hida, D.; Knudson, C.; Knudson, W.
Mechanisms involved in enhancement of the expression and function of aggrecanases by hyaluronan oligosaccharides
Arthritis Rheumatol.
64
187-197
2012
Bos taurus
Filou, S.; Stylianou, M.; Triantaphyllidou, I.E.; Papadas, T.; Mastronikolis, N.S.; Goumas, P.D.; Papachristou, D.J.; Ravazoula, P.; Skandalis, S.S.; Vynios, D.H.
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma
Biochimie
95
725-734
2013
Homo sapiens (O75173), Homo sapiens
Rao, N.; Ke, Z.; Liu, H.; Ho, C.; Kumar, S.; Xiang, W.; Zhu, Y.; Ge, R.
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice
Int. J. Cancer
133
294-306
2013
Mus musculus (Q8BNJ2)
Obika, M.; Vernon, R.; Gooden, M.; Braun, K.; Chan, C.; Wight, T.
ADAMTS-4 and biglycan are expressed at high levels and co-localize to podosomes during endothelial cell tubulogenesis in vitro
J. Histochem. Cytochem.
62
34-49
2014
Homo sapiens (Q75173)
Durham, T.; Klimkowski, V.; Rito, C.; Marimuthu, J.; Toth, J.; Liu, C.; Durbin, J.; Stout, S.; Adams, L.; Swearingen, C.; Lin, C.; Chambers, M.; Thirunavukkarasu, K.; Wiley, M.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis
J. Med. Chem.
57
10476-10485
2014
Homo sapiens (O75173)
Tauchi, R.; Imagama, S.; Natori, T.; Ohgomori, T.; Muramoto, A.; Shinjo, R.; Matsuyama, Y.; Ishiguro, N.; Kadomatsu, K.
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury
J. Neuroinflammation
9
53
2012
Rattus norvegicus (Q9ESP7)
Filomia, F.; Saxena, P.; Durante, C.; De Rienzo, F.; Cocchi, M.; Menziani, M.
Computational insights into ADAMTS4, ADAMTS5 and MMP13 inhibitor selectivity
Mol. Inform.
31
421-430
2012
Homo sapiens (O75173)
Wang, Z.; Luo, J.; Iwamoto, S.; Chen, Q.
Matrilin-2 is proteolytically cleaved by ADAMTS-4 and ADAMTS-5
Molecules
19
8472-8487
2014
Homo sapiens (O75173), Homo sapiens
Roberts, S.; Evans, H.; Wright, K.; van Niekerk, L.; Caterson, B.; Richardson, J.; Kumar, K.; Kuiper, J.
ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion
Osteoarthritis Cartilage
23
1622-1626
2015
Homo sapiens (O75173)
Walter, S.; Jumpertz, T.; Huettenrauch, M.; Ogorek, I.; Gerber, H.; Storck, S.E.; Zampar, S.; Dimitrov, M.; Lehmann, S.; Lepka, K.; Berndt, C.; Wiltfang, J.; Becker-Pauly, C.; Beher, D.; Pietrzik, C.U.; Fraering, P.C.; Wirths, O.; Weggen, S.
The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimers disease
Acta Neuropathol.
137
239-257
2019
Mus musculus (Q8BNJ2), Mus musculus
Shiraishi, A.; Mochizuki, S.; Miyakoshi, A.; Kojoh, K.; Okada, Y.
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)
Biochem. Biophys. Res. Commun.
469
62-69
2016
Homo sapiens (O75173), Homo sapiens
Durham, T.B.; Marimuthu, J.; Toth, J.L.; Liu, C.; Adams, L.; Mudra, D.R.; Swearingen, C.; Lin, C.; Chambers, M.G.; Thirunavukkarasu, K.; Wiley, M.R.
A highly selective hydantoin inhibitor of aggrecanase-1 and aggrecanase-2 with a low projected human dose
J. Med. Chem.
60
5933-5939
2017
Homo sapiens (O75173), Homo sapiens
Fowkes, M.M.; Lim, N.H.
Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants
Methods Mol. Biol.
2043
75-91
2020
Homo sapiens (O75173)
Fontanil, T.; Alvarez-Teijeiro, S.; Villaronga, M.A.; Mohamedi, Y.; Solares, L.; Moncada-Pazos, A.; Vega, J.A.; Garcia-Suarez, O.; Perez-Basterrechea, M.; Garcia-Pedrero, J.M.; Obaya, A.J.; Cal, S.
Cleavage of fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells
Oncotarget
8
13716-13729
2017
Homo sapiens (O75173)
Ren, P.; Hughes, M.; Krishnamoorthy, S.; Zou, S.; Zhang, L.; Wu, D.; Zhang, C.; Curci, J.A.; Coselli, J.S.; Milewicz, D.M.; LeMaire, S.A.; Shen, Y.H.
Critical role of ADAMTS-4 in the development of sporadic aortic aneurysm and dissection in mice
Sci. Rep.
7
12351
2017
Mus musculus (Q8BNJ2), Mus musculus
html completed
