Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.24.82 - ADAMTS-4 endopeptidase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Decreased ADAMTS-1, -9 and -20 levels in women with endometrial polyps: a possible link between extracellular matrix proteases and endometrial pathologies
Abscess
Histopathologic and immunohistochemical investigations of abscess fluid cells formed in the palato-gingival area.
Acute Coronary Syndrome
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome.
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice.
adamts-4 endopeptidase deficiency
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Alzheimer Disease
ADAMTS-4 in central nervous system pathologies.
The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Amyotrophic Lateral Sclerosis
ADAMTS-4 in central nervous system pathologies.
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Aneurysm
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Genetic correlates of wall shear stress in a patient-specific 3D-printed cerebral aneurysm model.
Aneurysm, Dissecting
Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection.
Angina Pectoris
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Angina, Stable
Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.
Angina, Unstable
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Aortic Aneurysm
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Aortic Aneurysm, Abdominal
ADAMTS-1 in abdominal aortic aneurysm.
MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
Aortic Aneurysm, Thoracic
ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections.
Aortic Rupture
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Arteriovenous Fistula
Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula.
Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency.
Arthritis
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo.
ADAMTS-4 in central nervous system pathologies.
ADAMTS-5: the story so far.
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes.
Aggrecanase-mediated cartilage degradation.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Cloning and expression of ADAM-related metalloproteases in equine laminitis.
Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4).
Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes.
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
Arthritis, Rheumatoid
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin.
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Identification of Potent Virtual Leads Specific to S1' Loop of ADAMTS4: Pharmacophore Modeling, 3D-QSAR, Molecular Docking and Dynamic Studies.
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
The low binding affinity of ADAMTS4 for citrullinated fibronectin may contribute to the destruction of joint cartilage in rheumatoid arthritis.
Asthma
Expression of ADAMs and their inhibitors in sputum from patients with asthma.
Atherosclerosis
A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.
ADAMTS proteases: key roles in atherosclerosis?
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.
Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome.
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice.
Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: Differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17.
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.
The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-? and requires Smads, p38 mitogen-activated protein kinase and c-Jun.
Autoimmune Diseases
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.
Bone Resorption
Histopathologic and immunohistochemical investigations of abscess fluid cells formed in the palato-gingival area.
Brain Injuries
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
Brain Injuries, Traumatic
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Brain Neoplasms
Proteases in brain tumour progression.
Breast Neoplasms
Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion.
Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma.
miR?365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer.
Carcinoma
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.
Carcinoma, Hepatocellular
Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines.
Carcinoma, Lewis Lung
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.
Cardiovascular Diseases
ADAMTS proteases in cardiovascular physiology and disease.
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Carotid Stenosis
Relationship between ADAMTS4 and carotid atherosclerotic plaque vulnerability in humans.
Central Nervous System Diseases
ADAMTS-4 in central nervous system pathologies.
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Chondrosarcoma
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes.
Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs.
Functional roles of CSPG4/NG2 in chondrosarcoma.
Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
Colonic Neoplasms
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.
Colorectal Neoplasms
ADAMTS expression in colorectal cancer.
ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer.
Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages.
Corneal Neovascularization
Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression.
Coronary Artery Disease
A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease.
Coronary Stenosis
Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome.
Diabetes, Gestational
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Down Syndrome
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Encephalomyelitis
Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis.
Epilepsy, Rolandic
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Facial Hemiatrophy
Changes in Cutaneous Gene Expression after Microvascular Free Tissue Transfer in Parry-Romberg Syndrome.
Fibrosarcoma
ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma.
Glioblastoma
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
Glioma
Expression of ADAMTS4 in Ewing's sarcoma.
Human glioblastomas overexpress ADAMTS-5 that degrades brevican.
Role of Adamts-1 in Pleomorphic Xanthoastrocytoma Tumor Cells Progression.
Tumor cell-matrix interaction: pericellular matrix degradation and metastasis.
Heart Diseases
Expression of ADAMTS-1 mRNA in myocardium of viral heart disease mice and its clinical significance.
Hydronephrosis
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy.
Hyperalgesia
Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican.
GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.
Hyperemia
Leptin induces ovulation in GnRH-deficient mice.
Hyperparathyroidism, Primary
Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism.
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
Hypertension
Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection.
Hypertension, Pulmonary
Effects of baicalin on collagen ? and collagen ??? expression in pulmonary arteries of rats with hypoxic pulmonary hypertension.
Hypogonadism
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Infarction, Middle Cerebral Artery
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Infections
Exuberant fibroblast activity compromises lung function via ADAMTS4.
[EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY].
Influenza in Birds
Exuberant fibroblast activity compromises lung function via ADAMTS4.
Insulin Resistance
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Intervertebral Disc Degeneration
APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.
Assessment of the Matrix Degenerative Effects of MMP-3, ADAMTS-4 and HTRA1 injected into a bovine Intervertebral Disc Organ Culture Model.
Association between ADAMTS-4 gene polymorphism and lumbar disc degeneration in Chinese Han population.
Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.
Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation.
Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NF-?B signaling pathway.
Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-?B.
Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration.
Interleukin-1? exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.
The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration.
[Electroacupuncture down-regulates expression of ADAMTS-4 of intervertebral disc in rats with lumbar intervertebral disc degeneration].
Intervertebral Disc Displacement
Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation.
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation.
Ischemic Stroke
ADAMTS-4 in central nervous system pathologies.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
[Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis].
Joint Diseases
ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.
Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene.
Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.
MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.
The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model.
TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
Joint Instability
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
Kashin-Beck Disease
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Leiomyoma
Versican Proteolysis by ADAMTS Proteases and its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.
Leukemia
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Lung Neoplasms
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Lyme Disease
Role of aggrecanase 1 in Lyme arthritis.
Melanoma
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Melanoma, Experimental
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Multiple Sclerosis
Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter.
Myocardial Infarction
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.
The quantification of ADAMTS4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction.
Myocarditis
ADAMTS-1 contributes to the antifibrotic effect of captopril by accelerating the degradation of type I collagen in chronic viral myocarditis.
[Association between myocardial ADAMTS-1 expression and myocardial fibrosis in a murine model of viral myocarditis]
Neoplasm Metastasis
Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential.
Neoplasms
ADAMs in cancer cell proliferation and progression.
ADAMTS expression in colorectal cancer.
ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer.
Anti-Inflammatory Effects of Conditioned Medium of Periodontal Ligament-Derived Stem Cells on Chondrocytes, Synoviocytes, and Meniscus Cells.
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
C/EBP? and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans.
Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.
Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: Sustained release of a local antiinflammatory therapeutic.
Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories.
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Expression of ADAMTS4 in Ewing's sarcoma.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells.
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer.
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.
Modification of palm oil for anti-inflammatory nutraceutical properties.
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.
Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer.
Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages.
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells.
Role of Adamts-1 in Pleomorphic Xanthoastrocytoma Tumor Cells Progression.
Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications.
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential.
Time-Dependent Effects of Arthroscopic Conditions on Human Articular Cartilage: An In Vivo Study.
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
Upregulation of tumor necrosis factor ? and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes.
Neurodegenerative Diseases
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Neuroinflammatory Diseases
ADAMTS-4 in central nervous system pathologies.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Obesity
Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development.
Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes.
Oligodendroglioma
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Osteoarthritis
ADAMTS proteases: key roles in atherosclerosis?
ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis.
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Advances in understanding cartilage remodeling.
Aggrecanase-1 (ADAMTS-4) interacts with alpha1-antitrypsin.
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.
Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs.
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
Characterization of neopeptides in equine articular cartilage degradation.
Cirsium japonicum var. maackii and apigenin block Hif-2?-induced osteoarthritic cartilage destruction.
Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity.
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors.
Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).
Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation.
Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage.
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Identification of Potent Virtual Leads Specific to S1' Loop of ADAMTS4: Pharmacophore Modeling, 3D-QSAR, Molecular Docking and Dynamic Studies.
IL-1?-induced miR-34a up-regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS-4.
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty.
Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.
Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis.
MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.
MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes.
Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.
Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5.
Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model.
The Effect of Mesenchymal Stem Cell Wharton's Jelly on ADAMTS-4 and iNOS Levels in Osteoarthritis Rat Model.
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.
The role of ADAMTS genes in the end stage of hip osteoarthritis.
The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis.
TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
TNF-? increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
[Effect of chondrogenesis related miR-4287 on expression of aggrecanase-1 in human chondrocytes].
Osteoarthritis, Knee
Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee osteoarthritis.
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.
The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis
[EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY].
Osteosarcoma
ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing.
ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone.
The role of significantly deregulated MicroRNAs in osteosarcoma based on bioinformatic analysis.
Ovarian Neoplasms
Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity.
Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer.
Periapical Granuloma
Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst.
Periodontal Diseases
A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis.
Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues.
Periodontitis
A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis.
Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues.
Pick Disease of the Brain
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Polycystic Ovary Syndrome
Abnormal expressions of ADAMTS-1, ADAMTS-9 and progesterone receptors are associated with lower oocyte maturation in women with polycystic ovary syndrome.
Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome.
Role of Versican and ADAMTS-1 in Polycystic Ovary Syndrome.
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Polymicrogyria
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Premature Birth
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Prostatic Neoplasms
Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.
Radicular Cyst
Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst.
Renal Insufficiency
Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency.
Sarcoma, Ewing
Expression of ADAMTS4 in Ewing's sarcoma.
Spinal Cord Injuries
ADAMTS-4 in central nervous system pathologies.
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury.
tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Stroke
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
Synovitis
The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy.
Transcriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis.
Tendinopathy
Promoter methylation status of the TIMP2 and ADAMTS4 genes and patellar tendinopathy.
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.
Thrombosis
Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages.
Tuberculosis
Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.
Tuberculosis, Spinal
Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.
Ureteral Obstruction
Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction.