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Disease on EC 3.4.24.77 - snapalysin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
22q11 Deletion Syndrome
The blood-brain and gut-vascular barriers: from the perspective of claudins.
Abortion, Habitual
Could the defects in the endometrial extracellular matrix during the implantation be a cause for impaired fertility?
Abortion, Missed
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Abortion, Spontaneous
Association of tissue inhibitor of metalloproteinase gene polymorphisms and unexplained recurrent spontaneous abortions in Han Chinese couples.
Biological potentials for a family of disintegrin and metalloproteinase (ADAMDEC)-1 in mouse normal pregnancy.
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Abscess
Anti-MMP-9 Antibody: A Promising Therapeutic Strategy for Treatment of Inflammatory Bowel Disease Complications with Fibrosis.
Acidosis
Hypercapnia attenuates ventilator-induced lung injury via a disintegrin and metalloprotease-17.
Acne Vulgaris
Augmentation of Gene Expression and Production of Promatrix Metalloproteinase 2 by Propionibacterium acnes-Derived Factors in Hamster Sebocytes and Dermal Fibroblasts: A Possible Mechanism for Acne Scarring.
Acrodermatitis
Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations.
Acute Coronary Syndrome
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial.
Elevated pregnancy-associated plasma protein-a in sera from type 2 diabetic patients with hypercholesterolemia: associations with carotid atherosclerosis and toe-brachial index.
Evaluation of pregnancy-associated plasma protein A as a prognostic indicator in acute coronary syndrome patients.
In-hospital outcome of patients with acute coronary syndrome: relationship with inflammation and remodeling markers.
Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study.
Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes.
Metalloproteinases in Diabetics and Nondiabetics during Acute Coronary Syndromes and after 3 Months.
Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome.
Pregnancy-associated plasma protein A as a marker of acute coronary syndromes.
Serum plasma pregnancy-associated protein A: a potential marker of echogenic carotid atherosclerotic plaques in asymptomatic hyperlipidemic subjects at high cardiovascular risk.
Serum profiles of matrix metalloproteinases and their tissue inhibitor in patients with acute coronary syndromes. The effects of short-term atorvastatin administration.
Transcription activity of MMP-2 and MMP-9 metalloproteinase genes and their tissue inhibitor (TIMP-2) in acute coronary syndrome patients.
[Changes in proinflammatory cytokine and destructive metalloproteinase levels during formation of unstable atherosclerotic plaque]
[Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].
Acute Kidney Injury
A Biochemical and Pharmacological Characterization of Phospholipase A2 and Metalloproteinase Fractions from Eastern Russell's Viper (Daboia siamensis) Venom: Two Major Components Associated with Acute Kidney Injury.
Angiostatin and matrix metalloprotease expression following ischemic acute renal failure.
Economic and clinical benefits of early identification of acute kidney injury using a urinary biomarker.
Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency.
The Accuracy of Urinary TIMP-2 and IGFBP7 for the Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis.
The role of meprin A in the pathogenesis of acute renal failure.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Tissue inhibitor metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) best predicts the development of acute kidney injury.
Urinary biomarkers TIMP-2 and IGFBP7 early predict acute kidney injury after major surgery.
Urinary cell cycle arrest proteins urinary tissue inhibitor of metalloprotease 2 and insulin-like growth factor binding protein 7 predict acute kidney injury after severe trauma: A prospective observational study.
Urine Biomarkers of Tubular Renal Cell Damage for the Prediction of Acute Kidney Injury After Cardiac Surgery-A Pilot Study.
Acute Lung Injury
Augmented metalloproteinase activity and acute lung injury in copper-deficient rats.
Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice.
adamts13 endopeptidase deficiency
ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome.
Allosteric activation of ADAMTS13 by von Willebrand factor.
Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura.
Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.
Reduced von Willebrand factor-cleaving protease levels in secondary thrombotic microangiopathies and other diseases.
Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies.
Adenocarcinoma
A two-dimensional model of cell movement. Well differentiated human rectal adenocarcinoma cells move as coherent sheets upon TPA stimulation.
Aberrant Expression of a Disintegrin and Metalloproteinase 17/Tumor Necrosis Factor-{alpha} Converting Enzyme Increases the Malignant Potential in Human Pancreatic Ductal Adenocarcinoma.
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.
Association of high level of serum M(r) approximately 92,000 metalloproteinase activity with lung metastasis of rat 13,762 NF mammary adenocarcinoma.
Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma.
Circulating levels of VCAM and MMP-2 may help identify patients with more aggressive prostate cancer.
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Dual combination therapy targeting DR5 and EMMPRIN in pancreatic adenocarcinoma.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma.
Immunohistochemical analysis on potential new molecular targets for esophageal cancer.
Immunohistochemical evaluation of type IV collagenase (72-kd metalloproteinase) in prostatic intraepithelial neoplasia.
Inhibition of beta-ionone on SGC-7901 cell proliferation and upregulation of metalloproteinases-1 and -2 expression.
Location of 72-kd metalloproteinase (type IV collagenase) in untreated prostatic adenocarcinoma.
Metalloproteinases and tissue inhibitor of metalloproteinase 1 (TIMP-1) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma.
Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma.
PGF2?-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer.
Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma.
Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.
Promoter methylation and expression of TIMP3 gene in gastric cancer.
Relationship between biomarker expression and allelic alteration in esophageal carcinoma.
STAT3 inhibition by STA21 increases cell surface expression of MICB and the release of soluble MICB by gastric adenocarcinoma cells.
Tissue inhibitor of metalloproteinase 2 (TIMP-2) expression in adenocarcinoma pleural effusions.
TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.
Transcriptional gene expression profiles of oesophageal adenocarcinoma and normal oesophageal tissues.
Ultrastructural study of TPA-induced cell motility: human well-differentiated rectal adenocarcinoma cells move as coherent sheets via localized modulation of cell-cell adhesion.
Adenocarcinoma of Lung
Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling.
Identification of relevant genetic alterations in cancer using topological data analysis.
Inhibitory effect of acetylsalicylic acid on metalloproteinase activity in human lung adenocarcinoma at different stages of differentiation.
Lentivirus-mediated disintegrin and metalloproteinase 17 RNA interference reversed the acquired resistance to gefitinib in lung adenocarcinoma cells in vitro.
miR?888 regulates cancer progression by targeting multiple targets in lung adenocarcinoma.
Adenoma
CpG island methylation in premalignant stages of gastric carcinoma.
Induction of matrix metalloprotease-7 is common in mucinous ovarian tumors including early stage disease.
Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer.
Adenomatous Polyposis Coli
Cell lines from the same cervical carcinoma but with different radiosensitivities exhibit different cDNA microarray patterns of gene expression.
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers.
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray.
Relation between normal rectal methylation, smoking status, and the presence or absence of colorectal adenomas.
Adenomyosis
[Expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase in adenomyosis]
Adrenocortical Adenoma
Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas.
Adrenocortical Carcinoma
Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas.
Airway Obstruction
Airway obstruction is increased in Pneumocystis-colonized HIV-infected outpatients.
Alopecia
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.
alpha 1-Antitrypsin Deficiency
Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency.
Alzheimer Disease
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.
A neglected modulator of insulin-degrading enzyme activity and conformation: The pH.
A novel metalloprotease in rat brain cleaves the amyloid precursor protein of Alzheimer's disease generating amyloidogenic fragments.
ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons.
ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.
Alpha-secretase activation--an approach to Alzheimer's disease therapy.
Alpha-Secretase Cleavage of the Amyloid Precursor Protein: Proteolysis Regulated by Signaling Pathways and Protein Trafficking.
alpha-secretase in Alzheimer's disease: molecular identity, regulation and therapeutic potential.
Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease.
Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis.
Catalytic Mechanism of Amyloid-? Peptide Degradation by Insulin Degrading Enzyme: Insights from Quantum Mechanics and Molecular Mechanics Style Møller-Plesset Second Order Perturbation Theory Calculation.
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme.
Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element.
Expression of the type 1 metalloproteinase in the rat hippocampus after the intracerebroventricular injection of ?-amyloid peptide (25-35).
Expression, purification and initial characterization of human meprin ? from Pichia pastoris.
Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population.
Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ?-mediated metalloproteinase 2 and 9 levels in ?-amyloid infused Alzheimer's disease rat model.
Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease.
Identification of a metalloprotease from Alzheimer's disease brain able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus.
Localization of tissue inhibitor of matrix metalloproteinases in Alzheimer's disease and normal brain.
Metalloendopeptidase EC 3.4.24.15 is necessary for Alzheimer's amyloid-beta peptide degradation.
Monoclonal antibodies against the human metalloprotease EC 3.4.24.15 label neurofibrillary tangles in Alzheimer's disease brain.
MT5-MMP controls APP and ?-CTF/C99 metabolism through proteolytic-dependent and -independent mechanisms relevant for Alzheimer's disease.
Non-covalent interaction of ubiquitin with insulin-degrading enzyme.
NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease.
Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase.
Phenanthroline impairs ?APP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells.
Proteolytic degradation of Alzheimer's disease amyloid beta-peptide by a metalloproteinase from microglia cells.
Regulation of the ?-secretase ADAM10 at transcriptional, translational and post-translational levels.
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin ?1; ADAP1) in neuroblastoma cells.
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.
Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.
Sulfuretin exerts diversified functions in the processing of amyloid precursor protein.
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.
The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitors.
The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
The Role of the Anti-Amyloidogenic Secretase ADAM10 in Shedding the APP-Like Proteins.
Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.
Ameloblastoma
[Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase in ameloblastoma]
Amelogenesis Imperfecta
Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype.
Amyloidosis
The role of beta-amyloid in the development of Alzheimer's disease.
Anemia
Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature.
Sjögren's syndrome initially presented as thrombotic thrombocytopenic purpura in a male patient: a case report and literature review.
Anemia, Hemolytic
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
Assessment and Monitoring of Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): Strategies to Improve Outcomes.
Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.
Investigational drugs in thrombotic thrombocytopenic purpura.
New developments in treatment modalities of thrombotic thrombocytopenic purpura.
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.
Silent Thrombotic Thrombocytopenic Purpura: PLASMIC, Lessons Learned, and Current Management Overview.
Utilizing a PLASMIC score-based approach in the management of suspected immune thrombotic thrombocytopenic purpura: a cost minimization analysis within the Harvard TMA Research Collaborative.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Anemia, Macrocytic
ADAMTS-13 deficiency: can it cause chronic renal failure?
Anemia, Sickle Cell
Absence of exaggerated pharmacology by recombinant ADAMTS13 in the rat and monkey.
Aneurysm
A potential role for glycated cross-links in abdominal aortic aneurysm disease.
Apolipoprotein E Knockout Mice Over-Expressing Human Tissue Inhibitor of Metalloproteinase 1 Are Protected against Aneurysm Formation but Not against Atherosclerotic Plaque Development.
CD43-mediated IFN-? production by CD8+ T cells promotes abdominal aortic aneurysm in mice.
Characterization of an elastase from aneurysmal aorta which degrades intact aortic elastin.
Concomitant coiling reduces metalloproteinase levels in flow diverter-treated aneurysms but anti-inflammatory treatment has no effect.
Early Increased MT1-MMP Expression and Late MMP-2 and MMP-9 Activity during Angiotensin II Induced Aneurysm Formation.
Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation.
In situ localization and quantification of mRNA for 92-kD type IV collagenase and its inhibitor in aneurysmal, occlusive, and normal aorta.
Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms.
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.
Matrix metalloproteinase-9 in cerebral aneurysms.
Metalloproteinase expression in venous aneurysms.
mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays.
Paracrine secretion of transforming growth factor-beta1 in aneurysm healing and stabilization with endovascular smooth muscle cell therapy.
Role of nuclear factor-kappa B activation in metalloproteinase-1, -3, and -9 secretion by human macrophages in vitro and rabbit foam cells produced in vivo.
The Novel Function of Advanced Glycation End Products in Regulation of MMP-9 Production.
Toward modeling the effects of regional material properties on the wall stress distribution of abdominal aortic aneurysms.
Aneurysm, Dissecting
A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection.
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
Decreased tissue inhibitor of metalloproteinase-2/matrix metalloproteinase ratio in the acute phase of aortic dissection.
MMP-12 as a new marker of Stanford-A acute aortic dissection.
Angina, Stable
In-hospital outcome of patients with acute coronary syndrome: relationship with inflammation and remodeling markers.
Angina, Unstable
Inflammatory imbalance between IL-10 and TNFalpha in unstable angina potential plaque stabilizing effects of IL-10.
Anhedonia
Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences.
Ankylosis
Update on the treatment of ankylosing spondylitis.
Anthrax
A novel pharmacophore model for the design of anthrax lethal factor inhibitors.
Alkaline earth metals are not required for the restoration of the apoform of anthrax lethal factor to its holoenzyme state.
Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin.
Anthrax lethal factor inhibitors as potential countermeasure of the infection.
Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity.
Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy.
Bacillus anthracis' Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes.
Certhrax toxin, an anthrax-related ADP-ribosyltransferase from Bacillus cereus.
Computational insights into the interaction of the anthrax lethal factor with the N-terminal region of its substrates.
Consequences and utility of the zinc-dependent metalloprotease activity of anthrax lethal toxin.
Discovery and development of anthrax lethal factor metalloproteinase inhibitors.
Effect of pH on the catalytic function and zinc content of native and immobilized anthrax lethal factor.
Effects of metalloprotease anthrax lethal factor on its peptide-based inhibitor R9LF-1.
Efficient production and characterization of Bacillus anthracis lethal factor and a novel inactive mutant rLFm-Y236F.
Efficient synthetic inhibitors of anthrax lethal factor.
Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor.
Guanidinylated 2,5-dideoxystreptamine derivatives as anthrax lethal factor inhibitors.
High metal substitution tolerance of anthrax lethal factor and characterization of its active copper-substituted analogue.
Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.
Identification of a lead small-molecule inhibitor of anthrax lethal toxin by using fluorescence-based high-throughput screening.
Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor.
Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.
Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group.
Inhibitors of the Metalloproteinase Anthrax Lethal Factor.
Low molecular weight inhibitors of the protease anthrax lethal factor.
N-terminal degradation activates the NLRP1B inflammasome.
Profiling lethal factor interacting proteins from human stomach using T7 phage display screening.
Proteolytic assay-based screening identifies a potent inhibitor of anthrax lethal factor.
Purification and Biophysical Characterization of the Core Protease Domain of Anthrax Lethal Factor.
Residue histidine 669 is essential for the catalytic activity of Bacillus anthracis lethal factor.
Role of N-terminal amino acids in the potency of anthrax lethal factor.
Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease.
Stop the killer: how to inhibit the anthrax lethal factor metalloprotease.
Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors.
The anthrax lethal factor and its MAPK kinase-specific metalloprotease activity.
The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin.
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.
Ultrasensitive detection of botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis.
Antiphospholipid Syndrome
Double positivity of anti-?2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody.
Aortic Aneurysm
Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation.
Shear Stress and Aortic Strain Associations With Biomarkers of Ascending Thoracic Aortic Aneurysm.
Aortic Aneurysm, Abdominal
Altered patterns of gene expression distinguishing ascending aortic aneurysms from abdominal aortic aneurysms: complementary DNA expression profiling in the molecular characterization of aortic disease.
Combining two potential causes of metalloproteinase secretion causes abdominal aortic aneurysms in rats: a new experimental model.
Decreased tissue inhibitor of metalloproteinase-2/matrix metalloproteinase ratio in the acute phase of aortic dissection.
Expression of a disintegrin and metalloprotease in human abdominal aortic aneurysms.
Homocysteine and metalloprotease-3 and -9 in patients with ascending Aorta Aneurysms.
Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging.
Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm.
Matrix metalloproteinase expression in the ascending aorta and aortic valve.
Matrix metalloproteinases in ascending aortic aneurysms: bicuspid versus trileaflet aortic valves.
Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline.
Pravastatin increases the expression of the tissue inhibitor of matrix metalloproteinase-1 and the oncogene Bax in human aortic abdominal aneurysms.
Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.
Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm.
Size matters: the relationship between MMP-9 expression and aortic diameter.
Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/?-Aminopropionitrile-Induced Abdominal Aortic Aneurysm.
Aortic Aneurysm, Thoracic
Association of modifiers and other genetic factors explain Marfan syndrome clinical variability.
Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
Temporal disparity in the induction of matrix metalloproteinases and tissue inhibitors of metalloproteinases after thoracic aortic aneurysm formation.
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections.
Aortic Diseases
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.
Appendicitis
Biomarkers to estimate the probability of complicated appendicitis.
Arrhythmias, Cardiac
[Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one].
Arteriovenous Fistula
Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation.
{beta}-Catenin is Markedly Induced in a Murine Model of an Arteriovenous Fistula: The Effect of Metalloproteinase Inhibition.
Arteriovenous Malformations
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations.
Arteritis
Elevated levels of 92-kd type IV collagenase (matrix metalloproteinase 9) in giant cell arteritis.
Arthritis
Activated gelatinase-B (MMP-9) and urokinase-type plasminogen activator in synovial fluids of patients with arthritis. Correlation with clinical and experimental variables of inflammation.
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.
ADAMTS Proteinases: Potential Therapeutic Targets?
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-18: a metalloproteinase with multiple functions.
ADAMTS-4 in central nervous system pathologies.
ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.
ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures.
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis.
Autoantibody and metalloproteinase activity in early arthritis.
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis.
Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis.
Changes in the concentration of plasma matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases-1 (TIMP-1) after total joint replacement in patients with arthritis.
Characterization of proADAMTS5 processing by proprotein convertases.
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Cross-domain inhibition of TACE ectodomain.
Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains.
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Differential expression of the small inducible cytokines GRO alpha and GRO beta by synovial fibroblasts in chronic arthritis: possible role in growth regulation.
Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli.
Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis.
Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis.
Engineering of TIMP-3 as a LAP-fusion protein for targeting to sites of inflammation.
Experimental Arthritis Is Dependent on Mouse Mast Cell Protease-5.
Feprazone Ameliorates TNF-?-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS-5 Signaling Pathway.
Fibronectin fragments in osteoarthritic synovial fluid.
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.
Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.
Inhibition of MMPs and ADAM/ADAMTS.
Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases.
Interleukin-1 receptor antagonist prevents expression of the metalloproteinase-generated neoepitope VDIPEN in antigen-induced arthritis.
Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Levels of serum matrix metalloproteinase-3 correlate with disease activity in the enthesitis-related arthritis category of juvenile idiopathic arthritis.
Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis.
Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome.
Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritis.
Rabbit models of arthritis: immunolocalization of matrix metalloproteinases and tissue inhibitor of metalloproteinase in synovium and cartilage.
Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8).
Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.
Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes.
Separation and identification methods for metalloproteinase inhibitors.
Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides.
TACE and other ADAM proteases as targets for drug discovery.
Targeting a cysteine protease from a pathobiont alleviates experimental arthritis.
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis.
The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes.
The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.
The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.
The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.
Transin/stromelysin expression in the synovium of rats with experimental erosive arthritis. In situ localization and kinetics of expression of the transformation-associated metalloproteinase in euthymic and athymic Lewis rats.
Wnt signaling genes of murine chromosome 15 are involved in gender-affected pathways of inflammatory arthritis.
[Gene transfer immunotherapy in rheumatoid arthritis: perspectives]
Arthritis, Gouty
Expression of matrix metalloproteinase-9 (gelatinase B) in gouty arthritis and stimulation of MMP-9 by urate crystals in macrophages.
Arthritis, Juvenile
Elevated serum receptor activator of NFkappaB ligand (RANKL), osteoprotegerin (OPG), matrix metalloproteinase (MMP)3, and ProMMP1 in patients with juvenile idiopathic arthritis.
Arthritis, Psoriatic
Quantitation of metalloproteinase gene expression in rheumatoid and psoriatic arthritis synovial tissue distal and proximal to the cartilage-pannus junction.
Arthritis, Reactive
Reduction of matrix metalloproteinase 8-neutrophil collagenase levels during long-term doxycycline treatment of reactive arthritis.
Arthritis, Rheumatoid
4'-Hydroxy aceclofenac suppresses the interleukin-1-induced production of promatrix metalloproteinases and release of sulfated-glycosaminoglycans from rabbit articular chondrocytes.
A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis.
A disintegrin and metalloproteinase (ADAM)-10 as a predictive factor for tocilizumab effectiveness in rheumatoid arthritis.
A synthetic peptide metalloproteinase inhibitor, but not TIMP, prevents the breakdown of proteoglycan within articular cartilage in vitro.
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.
A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release.
ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling.
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis.
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis.
Biomarkers for diagnosing and monitoring autoimmune diseases.
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Circulating levels of matrix metalloproteinases MMP-3 and MMP-2 in renal transplant recipients with chronic transplant nephropathy.
Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts.
Degradation of cartilage proteoglycans by a neutral proteinase secreted by rabbit bone-marrow macrophages in culture.
Design strategies for the identification of MMP-13 and Tace inhibitors.
Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells.
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.
Discovery of a series of imidazopyrazine small molecule inhibitors of the kinase MAPKAPK5, that show activity using in vitro and in vivo models of rheumatoid arthritis.
Effect of Tenidap on Metalloproteinase Gene Expression in Rheumatoid Arthritis: A Synovial Biopsy Study.
Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis.
Expression and localisation of the new metalloproteinase inhibitor RECK (reversion inducing cysteine-rich protein with Kazal motifs) in inflamed synovial membranes of patients with rheumatoid arthritis.
Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.
Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.
Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro-matrix metalloproteinase (MMP)-13.
Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals.
Inhibition of metalloproteinase activity of rheumatoid arthritis synovial cells by a new inhibitor [BE16627B; L-N-(N-hydroxy-2-isobutylsuccinamoyl)-seryl-L-valine]
Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts.
Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1.
Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes.
Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction.
Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes.
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis - results from the CHIKARA study.
Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and glycosaminoglycans in synovial fluid from patients with rheumatoid arthritis.
Messenger-RNA expression of matrix metalloproteinases, tissue inhibitors of metalloproteinases, and transcription factors in rheumatic synovial cells under mechanical stimuli.
Metalloproteinase inhibitors: new opportunities for the treatment of rheumatoid arthritis and osteoarthritis.
Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirty-nine patients at two centers.
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.
Novel functions of inactive rhomboid proteins in immunity and disease.
Polymorphism in the stromelysin 1 (matrix metalloproteinase 3) promoter gene and severity of rheumatoid arthritis: comment on the article by Constantin et al.
Regulation of collagenase gene expression in synovial cells.
Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes.
Selective MMP-12 inhibitors: WO-2008057254.
Serum Metalloprotease 3 (MMP-3) biomarker of therapeutic efficacy during treatment of rheumatoid arthritis.
Serum pro-matrix metalloproteinase 3 in rheumatoid arthritis: a reflection of local or systemic inflammation?
Simultaneous determination of CXCL7 chemokine and MMP3 metalloproteinase as biomarkers for rheumatoid arthritis.
Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis.
Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice.
Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis.
Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: Association with severity and progression of rheumatoid arthritis in a prospective study.
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
The discoidin domain receptor 2/annexin A2/matrix metalloproteinase 13 loop promotes joint destruction in arthritis through promoting migration and invasion of fibroblast-like synoviocytes.
The oral administration effect of drug mannuronic acid (M2000) on gene expression of matrix and tissue inhibitor of metalloproteinases in rheumatoid arthritis patients.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
TNF-alpha induces the transcription factor Egr-1, pro-inflammatory cytokines and cell proliferation in human skin fibroblasts and synovial lining cells.
Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer.
[Stromelysin-1 (MMP-3) level in the sera from patients with rheumatoid arthritis and other connective tissue diseases--clinical significances in early onset rheumatoid arthritis]
Arthrogryposis
Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders.
ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis.
Aspergillosis
Molecular cloning and sequencing of the cDNA and gene for a novel elastinolytic metalloproteinase from Aspergillus fumigatus and its expression in Escherichia coli.
Asthma
A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: A meta-analysis.
A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population.
A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation.
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.
ADAM 33 gene V4 C/G rs2787094 polymorphism in psoriasis.
ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma.
ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease.
ADAM33 gene polymorphisms associate with asthma susceptibility and severity in East China han population.
ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population.
ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children.
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
ADAM33 polymorphisms and phenotype associations in childhood asthma.
ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population.
ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats.
ADAM33: a novel therapeutic target for asthma.
ADAM8: a new therapeutic target for asthma.
Association between ADAM33 polymorphisms and asthma in a Thai population.
Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.
Association between ADAM33 polymorphisms and susceptibility with adult and childhood asthma among Jordanians.
Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: a meta-analysis.
Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.
Association between genetic polymorphisms in the ADAM33 gene and asthma risk: a meta-analysis.
Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China.
Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis.
Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations.
Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma.
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
Association of ADAM33 gene polymorphisms with asthma in a Chinese population.
Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia.
Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.
Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.
Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population.
Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population.
Asthma severity and genetics in Taiwan.
Asthma susceptible genes in Chinese population: a meta-analysis.
Crystal structure of the catalytic domain of human ADAM33.
Diversity of asthma: evolving concepts of pathophysiology and lessons from genetics.
DNA sequence variations of metalloproteinases: their role in asthma and COPD.
Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells.
Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment.
Effect of Xiaochuanping powder on the inflammatory response and airway remodeling in asthmatic rats.
Endothelial dysfunction and pentraxin-3 in clinically stable adult asthma patients.
Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.
Evaluation of Pregnancy-Associated Plasma Protein-A Levels in Patients with Chronic Obstructive Pulmonary Disease and Associations with Disease Severity.
Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.
Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Frequency of genetic polymorphisms of ADAM33 and their association with allergic rhinitis among Jordanians.
Genetic aspects of the etiology and treatment of asthma.
Genetic association of ADAM33 polymorphisms with childhood asthma in Chinese Han population: A case-control study.
Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population.
Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan.
Genetics and asthma disease susceptibility in the US Latino population.
Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.
IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.
Increased expression of ADAM33 and ADAM8 with disease progression in asthma.
Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.
Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients.
Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
Investigating the Association of ADAM33 Single Nucleotide Polymorphisms (SNPs) with Susceptibility to Allergic Asthma in Azerbaijan Population of Iran: A Case-control Study.
Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.
Mechanisms of asthma and implications for its prevention and treatment: a personal journey.
Metalloproteinase-9 is increased after toluene diisocyanate exposure in the induced sputum from patients with toluene diisocyanate-induced asthma.
Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model.
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat.
Platelet-derived growth factor and transforming growth factor-beta modulate the expression of matrix metalloproteinases and migratory function of human airway smooth muscle cells.
Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen.
Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study.
Protease domain of human ADAM33 produced by Drosophila S2 cells.
Selective MMP-12 inhibitors: WO-2008057254.
Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.
Silencing of ADAM33 restrains proliferation and induces apoptosis of airway smooth muscle cells in ovalbumin-induced asthma model.
Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease.
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.
T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians.
TGF-?1 stimulates epithelial-mesenchymal transition mediated by ADAM33.
The ADAM33 S2 Polymorphism Is Associated with Susceptibility to Pediatric Asthma in the Chinese Han Population.
The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation.
The genetics of asthma: ADAM33 as an example of a susceptibility gene.
The Metalloprotease-disintegrin ADAM8 is Essential for the Development of Experimental Asthma.
The Methylation Patterns of a Disintegrin and Metalloproteinase 33 Gene (ADAM33) in Adult Asthma.
The outer wall of small airways is a major site of remodeling in fatal asthma.
The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations.
The role of the epithelium in airway remodeling in asthma.
The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.
Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.
Upregulation of a disintegrin and metalloproteinase-33 by VEGF in human airway smooth muscle cells: Implications for asthma.
Upregulation of ADAM8 in the Airways of Mice with Allergic Bronchial Asthma.
[Relationship between disintegrin and metalloproteinase gene polymorphism of bronchial asthma and its severity in Uygur population].
[The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases].
Astrocytoma
Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification.
Expression of stromelysin 1 in human astrocytoma cell lines.
Expression of timp-1, timp-2, 72-kda and 92-kda type-iv collagenase transcripts in human astrocytoma cell-lines - correlation with astrocytoma cell invasiveness.
Implantation of C6 astrocytoma spheroid into collagen type I gels: invasive, proliferative, and enzymatic characterizations.
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.
Matrix metalloproteinase-9 interplays with the IGFBP2-IGFII complex to promote cell growth and motility in astrocytomas.
Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity.
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines.
The effects of alpha-secretase ADAM10 on the proteolysis of neuregulin-1.
The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors.
Thromboxane A(2) receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-varepsilon in the shedding of epidermal growth factor receptor ligands.
Transfection of an invasive human astrocytoma cell line with a TIMP-1 cDNA: modulation of astrocytoma invasive potential.
Atherosclerosis
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-18: a metalloproteinase with multiple functions.
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology.
ADAMTS7 in Cardiovascular Disease: From Bedside to Bench and Back Again?
Association Between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease.
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism.
Association of MMP-3 5A/6A gene polymorphism with susceptibility to carotid atherosclerosis.
Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease.
Association of serum ADAMTS7 levels and genetic variant rs1994016 with acute coronary syndrome in a Chinese population: A case control study.
Celecoxib combined with atorvastatin prevents progression of atherosclerosis.
Chlamydia pneumoniae (C. pneumoniae) infection upregulates atherosclerosis-related gene expression in human umbilical vein endothelial cells (HUVECs).
Coronary Artery Disease - Eighth International Congress. From prevention to intervention.
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease.
Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells.
Differential effects of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 on atherosclerosis and monocyte/macrophage invasion.
Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli.
Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis.
Electronegative LDL induces MMP-9 and TIMP-1 release in monocytes through CD14 activation: Inhibitory effect of glycosaminoglycan sulodexide.
Endothelial Cell-Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice.
Evaluation of Cardiovascular Changes in Children with BAVs.
Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals.
FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13).
Functional blockage of EMMPRIN ameliorates atherosclerosis in apolipoprotein E-deficient mice.
Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease.
IL-1?/MMP9 activation in primary human vascular smooth muscle-like cells: Exploring the role of TNF? and P2X7.
Induction of tissue inhibitor of metalloproteinase and its mitogenic response to endothelial cells in human atherosclerotic and restenotic lesions.
Interactions of monocytic cells with human endothelial cells stimulate monocytic metalloproteinase production.
Leptin and Vascular Smooth Muscle Cells.
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits.
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
Molecular imaging of vulnerable atherosclerotic plaques.
New trends in anti-atherosclerotic agents.
Non-Invasive Detection of Extracellular Matrix Metalloproteinase Inducer EMMPRIN, a New Therapeutic Target against Atherosclerosis, Inhibited by Endothelial Nitric Oxide.
Noncanonical Matrix Metalloprotease 1-Protease-Activated Receptor 1 Signaling Drives Progression of Atherosclerosis.
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
Overexpression of tissue inhibitor of metalloproteinase 3 in macrophages reduces atherosclerosis in low-density lipoprotein receptor knockout mice.
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding.
Pregnancy associated plasma protein-A (PAPP-A) as an early marker for the diagnosis of acute coronary syndrome.
Pregnancy Associated Plasma Protein-A (PAPP-A) Levels in Acute Coronary Syndrome: A Case Control Study in a Tertiary Care Centre.
Pregnancy-associated plasma protein-A: an emerging cardiac biomarker.
Radionuclide imaging: a molecular key to the atherosclerotic plaque.
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.
Selective MMP-12 inhibitors: WO-2008057254.
Stimulated release of endothelin-converting enzyme is simultaneous with tissue-type plasminogen activator and decrease in coronary heart disease.
Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling.
The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-? and requires Smads, p38 mitogen-activated protein kinase and c-Jun.
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
Upregulation of ADAMTS?7 and downregulation of COMP are associated with aortic aneurysm.
Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1?
Von Willebrand Factor and ADAMTS13 and long-term outcomes in patients undergoing percutaneous coronary intervention.
[Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk]
Atrial Fibrillation
Brain natriuretic peptide correlates with the extent of atrial fibrillation-associated silent brain lesions.
Decreased plasminogen activator inhibitor and tissue metalloproteinase inhibitor expression may promote increased metalloproteinase activity with increasing duration of human atrial fibrillation.
Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.
TGF-?1 and TIMP-4 regulate atrial fibrosis in atrial fibrillation secondary to rheumatic heart disease.
[Effects of matrix metalloproteinase-9 and tissue inhibitor-1 of metalloproteinase expression on atrial structural remodeling during chronic atrial fibrillation]
[Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation.]
[Role of matrix metalloproteinase and tissue inhibitor of metalloproteinase in atrial structural remodeling in patients with atrial fibrillation]
Atypical Hemolytic Uremic Syndrome
Deficiency of complement factor H-related proteins and autoantibody-positive hemolytic uremic syndrome in an infant with combined partial deficiencies and autoantibodies to complement factor H and ADAMTS13.
Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Thrombosis, Microangiopathies, and Inflammation.
Autoimmune Diseases
ADAM17 at the interface between inflammation and autoimmunity.
Changes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in the serum of patients with autoimmune diseases: association with age and disease activity.
Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres.
Novel functions of inactive rhomboid proteins in immunity and disease.
Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome.
Azoospermia
ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia.
Bacterial Infections
Cellular and molecular modification of egg envelope hardening in fertilization.
Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals.
Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure.
Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry.
Solution structure and dynamics of C-terminal regulatory domain of Vibrio vulnificus extracellular metalloprotease.
The matrix metalloproteinase gene GmMMP2 is activated in response to pathogenic infections in soybean.
Behcet Syndrome
The determination of matrix metalloproteinase 9 activity and gene expression levels in Behcet's disease patients with aneurysmal complications.
Bicuspid Aortic Valve Disease
Adamts5-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies.
Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves.
Metalloproteinase polymorphisms and bicuspid aortic valves.
Bile Duct Neoplasms
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Blister
Blister formation and skin damage induced by BaP1, a haemorrhagic metalloproteinase from the venom of the snake Bothrops asper.
Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model.
Matrix- metalloproteinase -2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox).
Bone Resorption
An active neutral metalloproteinase bound to the insoluble collagen in the mineralized phase matrix of adult rat calvaria.
Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study.
Effect of tetracyclines which have metalloproteinase inhibitory capacity on basal and heparin-stimulated bone resorption by chick osteoclasts.
Effects of angiotensin II type I receptor blocker losartan on orthodontic tooth movement.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Expression profile of matrix metalloproteinase-2 and -9 and their endogenous tissue inhibitors in osteonecrotic femoral heads.
Fibroblasts and Osteoblasts in Inflammation and Bone Damage.
Inhibition of bone resorption in vitro by human enkephalinase (EC 3.4.24.11), a neutral metalloendopeptidase.
Long-term effects of infliximab on bone and cartilage turnover markers in patients with rheumatoid arthritis.
Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion.
Osteogenic capacity of transgenic flax scaffolds.
Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis.
The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice.
Triiodothyronine induces collagenase-3 and gelatinase B expression in murine osteoblasts.
Zoledronate is a potent inhibitor of myeloma cell growth and secretion of IL-6 and MMP-1 by the tumoral environment.
Border Disease
Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants.
Botulism
High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes.
Identification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain Protease.
Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins.
Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease.
Tables of Toxicity of Botulinum and Tetanus Neurotoxins.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
Brachydactyly
Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.
Brain Diseases
Crosstalk between glia, extracellular matrix and neurons.
Effects of tricyclic compounds on membrane binding of bivalent cations, activities of acetylcholinesterase and some tissue proteases.
Brain Edema
Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats.
Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice.
Expression of matrix metalloproteinse-9 in thrombin-induced brain edema formation in rats.
Long-Term Outcomes in Patients Aged ?70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis.
Brain Infarction
Effects of tissue plasminogen activator on cerebral microvessels of rats during focal cerebral ischemia and reperfusion.
Brain Injuries
Crosstalk between glia, extracellular matrix and neurons.
Time dependent integration of matrix metalloproteinases and their targeted substrates directs axonal sprouting and synaptogenesis following central nervous system injury.
Brain Injuries, Traumatic
Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with moderate and severe traumatic brain injury.
Relative Deficiency of Plasma A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeats 13 Activity and Elevation of Human Neutrophil Peptides in Patients with Traumatic Brain Injury.
Rhubarb attenuates cerebral edema via inhibition of the extracellular signal-regulated kinase pathway following traumatic brain injury in rats.
Brain Ischemia
Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain.
Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia.
Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats.
Endothelin-1-mediated cerebrovascular remodeling is not associated with increased ischemic brain injury in diabetes.
Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats.
Role of HIF-1?-activated Epac1 on HSC-mediated neuroplasticity in stroke model.
Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.
Brain Neoplasms
A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells.
Comparative analysis of matrix metalloproteinases by immunocytochemistry, immunohistochemistry and zymography in human primary brain tumours.
Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors.
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.
Inhibition of glioma angiogenesis and invasion by SI-27, an anti-matrix metalloproteinase agent in a rat brain tumor model.
Metalloproteinase disintegrins ADAM8 and ADAM19 are highly regulated in human primary brain tumors and their expression levels and activities are associated with invasiveness.
Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.
Promoter methylation status of multiple genes in brain metastases of solid tumors.
Breast Neoplasms
5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells.
A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients.
A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.
A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer.
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
Abl Interactor 1 Regulates Src-Id1-Matrix Metalloproteinase 9 Axis and Is Required for Invadopodia Formation, Extracellular Matrix Degradation, and Tumor Growth of Human Breast Cancer Cells.
Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells.
Activated thrombin-activatable fibrinolysis inhibitor attenuates the angiogenic potential of endothelial cells: potential relevance to the breast tumour microenvironment.
Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells.
Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2.
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
ADAM28 is expressed by epithelial cells in human normal tissues And protects from C1q-induced cell death.
ADAMTS1 Promotes Adhesion to Extracellular Matrix Proteins and Predicts Prognosis in Early Stage Breast Cancer Patients.
ADAMTS1-mediated targeting of TSP-1 by PPAR? suppresses migration and invasion of breast cancer cells.
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
Alcohol Stimulates Activation of Snail, Epidermal Growth Factor Receptor Signaling, and Biomarkers of Epithelial-Mesenchymal Transition in Colon and Breast Cancer Cells.
Analysis of the Gene Expression Profile of Stromal Pro-Tumor Factors in Cancer-Associated Fibroblasts from Luminal Breast Carcinomas.
Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-?.
Assay of matrix metalloproteases types 8 and 9 by ELISA in human breast cancer.
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation.
Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine?disrupting chemicals.
Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells.
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells.
Characterization of a P-Rex1 gene signature in breast cancer cells.
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Collagenase-3 expression in breast myofibroblasts as a molecular marker of transition of ductal carcinoma in situ lesions to invasive ductal carcinomas.
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model.
Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis.
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Differential expression and androgen regulation of microRNAs and metalloprotease 13 in breast cancer cells.
DLC3 suppresses MT1-MMP-dependent matrix degradation by controlling RhoB and actin remodeling at endosomal membranes.
Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis.
Dynamics of internalization and recycling of the prometastatic membrane type 4 matrix metalloproteinase (MT4-MMP) in breast cancer cells.
Elevated NRD1 metalloprotease expression plays a role in breast cancer growth and proliferation.
Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells.
Enhanced RNA expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in human breast cancer.
Epigenetic silencing of the adhesion molecule ADAM23 is highly frequent in breast tumors.
Erratum to: Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.
Estrogenic and antiestrogenic effects of raloxifene on collagen metabolism in breast cancer MCF-7 cells.
Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model.
Expression and characterization of tissue inhibitor of metalloproteinase 4 from complex canine mammary carcinomas.
Expression of matrix metalloprotease-9 in vascular pericytes in human breast cancer.
Expression of MiR-335 and its target metalloproteinase genes: clinical significance in breast cancer.
Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation.
Human breast cancer cells contain a phosphoramidon-sensitive metalloproteinase which can process exogenous big endothelin-1 to endothelin-1: a proposed mitogen for human breast fibroblasts.
Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1).
IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways.
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
In vitro antitumor and antiangiogenic effects of Bothropoidin, a metalloproteinase from Bothrops pauloensis snake venom.
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat.
Induction of metalloproteinase (MMP1) expression by epidermal growth factor (EGF) receptor stimulation and serum deprivation in human breast tumour cells.
Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer.
Inhibition of cell invasion and migration by CEACAM1-4S in breast cancer.
Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4.
Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells.
Interaction between the ADAMTS-12 metalloprotease and fibulin-2 induces tumor-suppressive effects in breast cancer cells.
Interaction of 5-aza-2'-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells.
Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines.
Leptin induces cell migration and invasion in a FAK-Src-dependent manner in breast cancer cells.
Low serum level of pro-matrix metalloproteinase 2 correlates with aggressive behavior in breast carcinoma.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Metalloproteinase and TIMP expression by the human breast carcinoma cell line 8701-BC.
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression.
MiR-126 regulated breast cancer cell invasion by targeting ADAM9.
Modulation of monocyte matrix metalloproteinase-2 by breast adenocarcinoma cells.
Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Molecular profiling of ADAM12 in human bladder cancer.
MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells.
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray.
N-glycosylation regulates ADAM8 processing and activation.
NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer.
Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone.
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer.
Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours.
Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding.
Phospholipase C?1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/?- catenin/MMP7 signalling.
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor ?B-Matrix Metalloproteinase Signaling.
Pro-matrix metalloproteinase-2 transfection increases orthotopic primary growth and experimental metastasis of MDA-MB-231 human breast cancer cells in nude mice.
Production of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human breast carcinomas.
Prognostic impact of polymorphism of matrix metalloproteinase-2 and metalloproteinase tissue inhibitor-2 promoters in breast cancer in Tunisia: case-control study.
Prognostic significance of the combined expression of matrix metalloproteinase-9, urokinase type plasminogen activator and its receptor in breast cancer as measured by Northern blot analysis.
Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases.
Quantitative real-time reverse transcription-PCR assay for urokinase plasminogen activator, plasminogen activator inhibitor type 1, and tissue metalloproteinase inhibitor type 1 gene expressions in primary breast cancer.
Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.
Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells.
Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.
Selective localization of matrix metalloproteinase 9, beta1 integrins, and human lymphocyte antigen class I molecules on membrane vesicles shed by 8701-BC breast carcinoma cells.
SNX27-retromer assembly recycles MT1-MMP to invadopodia and promotes breast cancer metastasis.
SplicerAV: a tool for mining microarray expression data for changes in RNA processing.
Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation.
Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells.
Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.
Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.
Thalidomide combined with irradiation alters the activity of two proteases.
The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer.
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation.
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway.
The favorable prognostic impact of tissue inhibitor of matrix metalloproteinases-1 protein overexpression in breast cancer cells.
The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression.
The interaction between aromatase, metalloproteinase 2,9 and cd44 in breast cancer.
The prognostic role of interleukin-8 (IL-8) and matrix metalloproteinases -2 and -9 in lymph node-negative untreated breast cancer patients.
The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers.
The Transmodulation of HER2 and EGFR by Substance P in Breast Cancer Cells Requires c-Src and Metalloproteinase Activation.
TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients.
Tissue inhibitor metalloproteinase type-1 (TIMP-1), a novel cancer biomarker predicting response of adjuvant anthracycline-based chemotherapy in patients afflicted with primary breast cancer.
Tissue inhibitor of metalloprotease (TIMP)-1 and proliferative behaviour of clonal breast cancer cells.
Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success.
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells.
Tumor-Contacted Neutrophils Promote Metastasis by a CD90-TIMP-1 Juxtacrine-Paracrine Loop.
Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients.
[Associating of polymorphism in the promoter regions of genes of metalloproteinase (MMP2, MMP3, MMP9) with options of the clinical course of breast cancer in Russian women].
[Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer]
[Relationship between tissue inhibitors of metalloproteinase and metastasis and prognosis in breast cancer]
[The correlation of synuclein-? and matrix metalloproteinase 9 in breast cancer].
Bronchiectasis
Gelatinolytic and type IV collagenolytic activity in bronchiectasis.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
Bronchiolitis Obliterans
Lung transplant metalloproteinase levels are elevated prior to bronchiolitis obliterans syndrome.
Metalloproteinase Profiling in Lung Transplant Recipients With Good Outcome and Bronchiolitis Obliterans Syndrome.
Bronchitis, Chronic
Increased serum concentrations of tissue inhibitor of metalloproteinase-1 in COPD patients.
Burkitt Lymphoma
Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice.
Bursitis
Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise.
CADASIL
Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
[Subcortical ischemic vascular dementia: lesson from hereditary cerebral small vessel disease].
Calciphylaxis
Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases.
Carcinogenesis
A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma.
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis.
ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126.
Antisense IL-10 abrogates the inhibitory effects of IL-10 production by transfected tumor cells.
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Correction: Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions.
CpG island methylation in premalignant stages of gastric carcinoma.
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Determining the combined effect on invasiveness and carcinogenesis process: matrix metalloproteinas/tissue inhibitor of metalloproteinase ratio.
Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma.
Drug Discovery and Repurposing Inhibits a Major Gut Pathogen-Derived Oncogenic Toxin.
Emodin modulates epigenetic modifications and suppresses bladder carcinoma cell growth.
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.
ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.
Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications.
Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs).
Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation.
Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma.
Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer.
Inflammatory and repair pathways induced in human bronchoalveolar lavage cells with ozone inhalation.
Inflammatory markers in cancer: Potential resources.
Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices.
Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.
Kaposi' s sarcoma in HIV-positive patients: the state of art in the HAART-era.
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
Matrix metalloproteinases in tumorigenesis: an evolving paradigm.
MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to Sorafenib.
MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression.
miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis.
Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.
No Association of Matrix Metalloproteinase [MMP]-2 (-735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (-418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility.
Oncogenic Notch Triggers Neoplastic Tumorigenesis in a Transition-Zone-like Tissue Microenvironment.
Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response.
Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis.
Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis.
Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis.
Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions.
Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis.
Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.
The role of matrix metalloproteinase in the intimal sarcoma-like cells derived from endarterectomized tissues from a chronic thromboembolic pulmonary hypertension patient.
Thymosin ? as an Actin-binding Protein with a Variety of Functions.
Transcript response of soft coral (Scleronephthya gracillimum) on exposure to polycyclic aromatic hydrocarbons.
Upregulated expression of MMP-9 in gingival epithelial cells induced by prolonged stimulation with arecoline.
Upregulated miR-106a plays an oncogenic role in pancreatic cancer.
Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer.
Carcinoma
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer.
ADAM28 is expressed by epithelial cells in human normal tissues And protects from C1q-induced cell death.
ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas.
ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression.
Alveolar macrophage secretion of a 92-kDa gelatinase in response to bleomycin.
Analysis of expression of matrix metalloproteinases-2 and -9 in hypopharyngeal squamous cell carcinoma by in situ hybridization.
Anti-invasive effect of MMI-166, a new selective matrix metalloproteinase inhibitor, in cervical carcinoma cell lines.
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma.
Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma.
Augmented membrane type 1 matrix metalloproteinase (MT1-MMP):MMP-2 messenger RNA ratio in gastric carcinomas with poor prognosis.
Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells.
Beta-catenin regulates the gene of MMP-26, a novel metalloproteinase expressed both in carcinomas and normal epithelial cells.
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value.
CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus.
Characterization of gene expression in major types of salivary gland carcinomas with epithelial differentiation.
Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma.
Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma.
Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma.
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis.
Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines.
Correlation of the in situ detection of polymerase chain reaction-amplified metalloproteinase complementary DNAs and their inhibitors with prognosis in cervical carcinoma.
CpG island methylation in premalignant stages of gastric carcinoma.
Critical function for ADAM9 in mouse prostate cancer.
Death receptor 6 promotes ovarian cancer cell migration through KIF11.
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.
Dual stromelysin-3 function during natural mouse mammary tumor virus-ras tumor progression.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Effect of human seminal fluid on production of messenger ribonucleic acid for metalloproteinase 2 and metalloproteinase 9 in cervical epithelial carcinoma cells.
Effects of basic fibroblast factor (bFGF) on MMP-2, TIMP-2, and type-I collagen levels in human lung carcinoma fibroblasts.
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF.
Elevated levels of serum metalloproteinase 9 in patients with esophageal squamous cell carcinoma.
Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion.
Exogenous introduction of tissue inhibitor of metalloproteinase 2 reduces accelerated growth of TGF-?-disrupted diffuse-type gastric carcinoma.
Exposure to vinorelbine inhibits in vitro proliferation and invasiveness of transitional cell bladder carcinoma.
Expression and characterization of tissue inhibitor of metalloproteinase 4 from complex canine mammary carcinomas.
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance.
Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours.
Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma.
Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract.
Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma.
Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas.
Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma.
Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival.
Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma.
Expression of stromelysin 3 in keratoarcanthoma and squamous cell carcinoma.
Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro.
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus.
Gelatinases and metalloproteinase inhibitor secreted by murine colonic carcinoma cells with differing metastatic potential.
Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells.
High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma.
High molecular mass type i.v. collagen-specific metalloprotease from human carcinoma tissue.
Identification of a metalloproteinase co-purifying with rat tumour collagenase and the characteristics of fragments of both enzymes.
Immunohistochemical analysis on potential new molecular targets for esophageal cancer.
In situ detection of PCR-amplified metalloproteinase cDNAs, their inhibitors and human papillomavirus transcripts in cervical carcinoma cell lines.
In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts.
Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma.
Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Induction of growth factor-receptor and metalloproteinase genes by epidermal growth factor and/or transforming growth factor-alpha in human gastric carcinoma cell line MKN-28.
Inhibition of epidermal growth factor-induced invasion by dexamethasone and AP-1 decoy in human squamous cell carcinoma cell lines.
Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts.
Interstitial collagenase gene expression in oral squamous cell carcinoma.
Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.
Mangiferin inhibits tumor necrosis factor-?-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-?B activity.
Matrilysin-2 (matrix metalloproteinase-26) is upregulated in keratinocytes during wound repair and early skin carcinogenesis.
Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury.
Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma.
Melanocyte mediated paracrine induction of extracellular matrix degrading proteases in squamous cell carcinoma cells.
Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration.
Metalloprotease-specific poly(ethylene glycol) methyl ether-peptide-doxorubicin conjugate for targeting anticancer drug delivery based on angiogenesis.
Methylation of TIMP3 in esophageal squamous cell carcinoma.
Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining.
MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients.
Modulation of matrilysin levels in colon carcinoma cell lines affects tumorigenicity in vivo.
Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer.
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.
New relationships between prostatic intraepithelial neoplasia and prostatic carcinoma.
Ovarian carcinoma regulation of matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase through beta1 integrin.
Overexpression of ADAM9 Promotes Colon Cancer Cells Invasion.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures.
Probing the dimeric structure of porcine aminoacylase 1 by mass spectrometric and modeling procedures.
Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma.
Prognostic significance of TIMP-2, MMP-2, and MMP-9 on high-grade serous ovarian carcinoma using digital image analysis.
Prognostic value of microvessel density, matrix metalloproteinase-9 and p53 protein expression in esophageal cancer.
Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein.
Purification and characterization of extracellular matrix-degrading metalloproteinase, matrin (pump-1), secreted from human rectal carcinoma cell line.
Ras levels and metalloproteinase activity in normal versus neoplastic rat mammary tissues.
Recurrence patterns in locally advanced cervical carcinoma: role of nodal status and 72-kDa metalloproteinase index.
Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact.
Relation between laminin-5 gamma 2 chain and cell surface metalloproteinase MT1-MMP in clear cell carcinoma of the ovary.
Relationship between metalloprotease expression in tumour and stromal cells and aggressive behaviour in prostate carcinoma: Simultaneous high-throughput study of multiple metalloproteases and their inhibitors using tissue array analysis of radical prostatectomy samples.
Role and regulation of expression of 92-kDa type-IV collagenase (MMP-9) in 2 invasive squamous-cell-carcinoma cell lines of the oral cavity.
Role of beta2-chimaerin in the behaviour of murine mammary carcinoma cells in response to extracellular matrix components.
Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis.
Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma.
Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.
SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas.
Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells.
Stromelysin-3 expression in early (pT1) carcinomas and pseudoinvasive lesions of the colorectum.
Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model.
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.
The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer.
The 72-kDa metalloproteinase immunostaining in cervical carcinoma: relationship with lymph nodal involvement.
The ADAMTS1 protease gene is required for mammary tumor growth and metastasis.
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
The ALCAM shedding by the metalloprotease ADAM17/TACE is involved in motility of ovarian carcinoma cells.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.
The expression of matrix metalloproteinases-2 and -9 and their tissue inhibitor 2 in pancreatic ductal and ampullary carcinoma and their relation to angiogenesis and clinicopathological parameters.
The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma.
The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
The metalloproteinase inhibitor TIMP-2 is down-regulated by androgens in LNCaP prostate carcinoma cells.
The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression.
Thrombin conducts epithelial?mesenchymal transition via protease?activated receptor?1 in human gastric cancer.
Tissue inhibitor of metalloproteinase expression. A target for gene therapy in renal cell carcinoma.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma.
White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues.
[Effects of TIMP-2 gene transfection on biological behaviors of a metastatic human lung carcinoma cell line]
[Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma].
[Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma]
[Relationship of expression unbalance of matrix metalloproteinase and tissue inhibitor of metalloproteinase to invasiveness and metastasis in gastric carcinomas]
Carcinoma in Situ
Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model.
Carcinoma, Adenoid Cystic
[Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma]
Carcinoma, Basal Cell
Expression of stromelysin 3 in keratoarcanthoma and squamous cell carcinoma.
Carcinoma, Bronchogenic
Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours.
Carcinoma, Ductal
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma.
Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course.
Carcinoma, Embryonal
Expression of extracellular matrix-degrading metalloproteinases and metalloproteinase inhibitors is developmentally regulated during endoderm differentiation of embryonal carcinoma cells.
Carcinoma, Hepatocellular
A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression.
A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy.
Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells.
Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines.
Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma.
Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model.
Dibutyryl cyclic AMP-induced enhancement of tissue inhibitor of metalloproteinases-3 expression and its possible relation to the invasive activity of the human hepatoma cell line PLC/PRF/5.
Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: relevance to intracellular signaling pathways.
Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells.
Expression of matrix metalloproteinases (MMPs) in cultured hepatocellular carcinoma (HCC) cells and surgically resected HCC tissues.
Gene polymorphisms of Interleukin 1? and Metalloproteinase 3 in Hepatitis C Infected Patients and Hepatocellular Carcinoma Patients.
In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis.
Increasing EMMPRIN and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters.
Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells.
Krüppel?like factor expression and correlation with FAK, MMP?9 and E?cadherin expression in hepatocellular carcinoma.
Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance.
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Metalloendoprotease inhibitors block protein synthesis, intracellular transport, and endocytosis in hepatoma cells.
Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma.
miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC.
Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor.
Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma.
Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy.
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.
Serum collagenase activity in patients with chronic liver disease.
Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study.
Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9.
The important role of ADAM8 in the progression of hepatocellular carcinoma induced by diethylnitrosamine in mice.
Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma.
[Clinical usefulness of plasma activities of gelatinase (matrix metalloproteinase-2 and 9) in chronic liver disease]
Carcinoma, Intraductal, Noninfiltrating
BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression.
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course.
Carcinoma, Lewis Lung
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Metalloprotease-specific poly(ethylene glycol) methyl ether-peptide-doxorubicin conjugate for targeting anticancer drug delivery based on angiogenesis.
Carcinoma, Non-Small-Cell Lung
ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer.
Angiogenesis inhibitors in the treatment of lung cancer.
Association between expression of activated 72-kilodalton gelatinase and tumor spread in non-small-cell lung carcinoma.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Cerebral ischemic events in patients with advanced lung or prostate cancer.
Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer.
Combined RNAi targeting human Stat3 and ADAM9 as gene therapy for non-small cell lung cancer.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non-Small Cell Lung Cancer.
Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.
Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis.
Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients.
Serum tissue inhibitors of metalloproteinase-1 and -2 in patients with non-small cell lung cancer.
Video-assisted thoracic surgery lobectomy for lung cancer is associated with less immunochemokine disturbances than thoracotomy.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
[The serum concentration of metalloproteinase 9 and 2 in non-small cell lung cancer patients]
Carcinoma, Ovarian Epithelial
Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma.
Inhibition of matrilysin expression by antisense or RNA interference decreases lysophosphatidic acid-induced epithelial ovarian cancer invasion.
Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers.
Tripartite Motif-Containing Protein 59 (TRIM59) Promotes Epithelial Ovarian Cancer Progression via the Focal Adhesion Kinase(FAK)/AKT/Matrix Metalloproteinase (MMP) Pathway.
[Expression and activity of proteases in metastasis of ovarian cancer].
Carcinoma, Renal Cell
ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression.
CD147 and VEGF expression in advanced renal cell carcinoma and their prognostic value.
Endothelin-2-converting enzyme from human renal adenocarcinoma cells is a phosphoramidon-sensitive, membrane-bound metalloprotease.
Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinoma.
Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters.
MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients.
Significant relationship of matrix metalloproteinase 9 with nuclear grade and prognostic impact of tissue inhibitor of metalloproteinase 2 for incidental clear cell renal cell carcinoma.
Tissue inhibitor of metalloproteinase expression. A target for gene therapy in renal cell carcinoma.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Carcinoma, Squamous Cell
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro.
Inhibition of epidermal growth factor-induced invasion by dexamethasone and AP-1 decoy in human squamous cell carcinoma cell lines.
Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts.
Interstitial collagenase gene expression in oral squamous cell carcinoma.
Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.
Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma.
Melanocyte mediated paracrine induction of extracellular matrix degrading proteases in squamous cell carcinoma cells.
Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer.
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures.
Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact.
TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.
The role of the matrix metalloproteinase stromelysin in the progression of squamous cell carcinomas.
Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression.
[Expression and significance of matrix metalloproteinase and tissue inhibitor of metalloproteinase in nasal cavity squamous cell carcinoma].
Carcinoma, Transitional Cell
Exposure to vinorelbine inhibits in vitro proliferation and invasiveness of transitional cell bladder carcinoma.
Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract.
Expression of metalloproteinase-2, metalloproteinase-9, and tissue inhibitor of metalloproteinase-1 in transitional cell carcinoma of upper urinary tract: correlation with tumor stage and survival.
Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Urinary type IV collagenase: elevated levels are associated with bladder transitional cell carcinoma.
Cardiomegaly
A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy.
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy.
Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload.
In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on fetal and adult cardiac gene expression and adult cardiac and renal morphology.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Role of the epidermal growth factor receptor in signaling strain-dependent activation of the brain natriuretic peptide gene.
Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of SGK-1.
Upregulation of Nox4 Promotes Angiotensin II-Induced Epidermal Growth Factor Receptor Activation and Subsequent Cardiac Hypertrophy by Increasing ADAM17 Expression.
[Membrane-anchored heparin-binding EGF-like growth factor processing by ADAM12 in cardiac hypertrophy]
[The role of HB-EGF in angiotensin II--signaling]
Cardiomyopathies
Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs.
Changes in Metalloproteinase and Tissue Inhibitor of Metalloproteinase during Tachycardia-Induced Cardiomyopathy by Rapid Atrial Pacing in Dogs.
Comparison of levels of matrix metalloproteinase-2 and -3 in patients with ischemic cardiomyopathy versus nonischemic cardiomyopathy.
Cardiomyopathy, Dilated
Impact of Pycnogenol on cardiac extracellular matrix remodeling induced by L-NAME administration to old mice.
Plasma profiling determinants of matrix homeostasis in paediatric dilated cardiomyopathy.
Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links.
Cardiomyopathy, Hypertrophic
Plasma metalloproteinase levels and left ventricular remodeling in hypertrophic cardiomyopathy in patients with an identical mutation.
Cardiovascular Diseases
ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease.
Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis.
Coronary Artery Disease - Eighth International Congress. From prevention to intervention.
Hypothesis: Metalloproteinase Inhibitors Decrease Risks of Cardiovascular Disease.
In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.
Inducible reduction in pregnancy-associated plasma protein-a gene expression inhibits established atherosclerotic plaque progression in mice.
Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity.
MMP-2 mediates angiotensin II-induced hypertension under the transcriptional control of MMP-7 and TACE.
Pregnancy-associated plasma protein-A promotes TF procoagulant activity in human endothelial cells by Akt-NF-?B axis.
Selenium modulates MMP2 expression through the TGF?1/Smad signalling pathway in human umbilical vein endothelial cells and rabbits following lipid disturbance.
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
Targeted Inhibition of Pregnancy-Associated Plasma Protein-A Activity Reduces Atherosclerotic Plaque Burden in Mice.
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1?
Vasopeptidase inhibitors: will they have a role in clinical practice?
[Association of gamma glutamyltransferase, metabolic syndrome and cardiovascular risk]
Carotid Stenosis
Elevated circulating metalloproteinase 7 predicts recurrent cardiovascular events in patients with carotid stenosis: a prospective cohort study.
MMP-12 as a new marker of Stanford-A acute aortic dissection.
NGAL and MMP-9/NGAL as biomarkers of plaque vulnerability and targets of statins in patients with carotid atherosclerosis.
cathepsin l deficiency
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Central Nervous System Diseases
ADAMTS-4 in central nervous system pathologies.
Cerebral Hemorrhage
Collagenase-induced intrastriatal hemorrhage in rats results in long-term locomotor deficits.
Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia.
Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat.
Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study.
Cervical Intraepithelial Neoplasia
Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining.
Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling.
Charcot-Marie-Tooth Disease
Characterising the phenotype and mode of inheritance of patients with inherited peripheral neuropathies carrying MME mutations.
Cholangiocarcinoma
Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.
Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression.
Cholangitis, Sclerosing
A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis.
Cholera
A dipeptide metalloendoprotease substrate completely blocks the response of cells in culture to cholera toxin.
Cholera vaccine candidate 638: intranasal immunogenicity and expression of a foreign antigen from the pulmonary pathogen Coccidioides immitis.
Structural characterization of metalloprotease vibriolysin of cholera pathogen Vibrio cholerae.
Vibrio cholerae hemagglutinin(HA)/protease: An extracellular metalloprotease with multiple pathogenic activities.
Vibrio cholerae metalloproteinase degrades intestinal mucin and facilitates enterotoxin-induced secretion from rat intestine.
Cholestasis
Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Cholestasis, Intrahepatic
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Cholesteatoma
Evaluation of significant gene expression changes in congenital and acquired cholesteatoma.
Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma.
Chondroma
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Chondrosarcoma
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma.
Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs.
Degradation of rat chondrosarcoma proteoglycans by a neutral metalloprotease from rabbit chondrocytes.
Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects.
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Immunolocalization of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomas.
Interleukin-10 does not affect IL-1-induced interleukin-6 and metalloproteinase production in human chondrosarcoma cells, SW1353.
Interleukin-1? induced nuclear factor-?B binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells.
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Production of matrix metalloproteinases and a metalloproteinase inhibitor by swarm rat chondrosarcoma.
siRNA mediated inhibition of MMP-1 reduces invasive potential of a human chondrosarcoma cell line.
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression.
Chorioamnionitis
SAR150640, a selective beta3-adrenoceptor agonist, prevents human myometrial remodelling and activation of matrix metalloproteinase in an in vitro model of chorioamnionitis.
Choriocarcinoma
Down-regulation and promoter methylation of tissue inhibitor of metalloproteinase 3 in choriocarcinoma.
Inhibition of cytotrophoblastic (JEG-3) cell invasion by interleukin 12 involves an interferon gamma-mediated pathway.
Overexpression of Endogenous TIMP-2 Increases the Proliferation of BeWo Choriocarcinoma Cells Through the MAPK-Signaling Pathway.
Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases.
The efficacy of specific IVIG anti-idiotypic antibodies in antiphospholipid syndrome (APS): trophoblast invasiveness and APS animal model.
Choroidal Neovascularization
Reduction of experimental laser-induced choroidal neovascularization by orally administered BPHA, a selective metalloproteinase inhibitor.
Sorsby Fundus Dystrophy Mutation in Tissue Inhibitor of Metalloproteinase 3 (TIMP3) promotes Choroidal Neovascularization via a Fibroblast Growth Factor-dependent Mechanism.
Chronic Kidney Disease-Mineral and Bone Disorder
ADAM17, a New Player in the Pathogenesis of Chronic Kidney Disease-Mineral and Bone Disorder.
Chronic Periodontitis
Erratum: Elastase and metalloproteinase 9 concentrations in saliva in patients with chronic periodontitis.
Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells.
MMP-13 and TIMP-1 determinations in progressive chronic periodontitis.
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis.
[Analysis of salivary protease spectrum in chronic periodontitis].
[Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis].
Coinfection
Anaplasma phagocytophilum-Borrelia burgdorferi coinfection enhances chemokine, cytokine, and matrix metalloprotease expression by human brain microvascular endothelial cells.
Colitis
Absence of intestinal PPAR? aggravates acute infectious colitis in mice through a lipocalin-2-dependent pathway.
Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain.
Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation.
Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis.
Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?
Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine.
Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine.
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP.
Treatment with a Zinc Metalloprotease Purified from Bothrops moojeni Snake Venom (BmooMP-Alpha-I) Reduces the Inflammation in an Experimental Model of Dextran Sulfate Sodium-Induced Colitis.
Zerumbone Suppresses Enterotoxigenic Bacteroides fragilis Infection-Induced Colonic Inflammation through Inhibition of NF-??.
Colitis, Collagenous
Fibrogenesis and fibrolysis in collagenous colitis. Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and -13, and TIMP-1 gene expression.
Colitis, Ulcerative
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.
Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis.
Matrix metalloproteinase levels are elevated in inflammatory bowel disease.
Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction.
Protective role of metalloproteinase inhibitor (AE-941) on ulcerative colitis in rats.
Colitis-Associated Neoplasms
Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis.
Coloboma
Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure.
Colonic Neoplasms
A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-?/Smad2/3 signalling pathway.
A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments.
Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations.
Colon cancer cell-derived tumor necrosis factor-alpha mediates the tumor growth-promoting response in macrophages by up-regulating the colony-stimulating factor-1 pathway.
Combined Therapeutic Effects of Vinblastine and Astragalus Saponins in Human Colon Cancer Cells and Tumor Xenograft via Inhibition of Tumor Growth and Proangiogenic Factors.
Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor.
Differential regulation of MMP7 in colon cancer cells resistant and sensitive to oxaliplatin-induced cell death.
Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab.
Extra- and Intracellular Imaging of human Matrix Metalloprotease 11 (hMMP-11) with a Cell-Penetrating FRET-Substrate.
Glycine-extended gastrin induces matrix metalloproteinase-1- and -3-mediated invasion of human colon cancer cells through type I collagen gel and Matrigel.
Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extracts.
Insulin-degrading enzyme in a human colon adenocarcinoma cell line (Caco-2).
Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts.
Modifying Effects of Dietary Factors on (-)-Epigallocatechin-3-gallate-induced Pro-matrix Metalloproteinase-7 Production in HT-29 Human Colorectal Cancer Cells.
Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells.
Restoration of caveolin-1 expression suppresses growth, membrane-type-4 metalloproteinase expression and metastasis-associated activities in colon cancer cells.
Retinoic acids reduce matrilysin (matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancer.
Smad4 inactivation promotes malignancy and drug resistance of colon cancer.
Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase.
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line.
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: selective role of PKC-alpha and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment.
Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway.
Colorectal Neoplasms
A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer.
Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol.
Clinicopathologic and Prognostic Significance of Metalloproteinase Tissue Inhibitor-2 Promoters in Tunisian Colorectal Cancer: A Case-Control Study.
Clinicopathological analysis of colorectal cancers in the elderly.
Correspondence re: N-B. Liabakk et al., matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res., 56: 190-196, 1966.
Differing expression of metalloprotease and of adhesion molecules in signet-ring cell and intestinal colorectal carcinoma.
Enhanced activity of meprin-?, a pro-migratory and pro-angiogenic protease, in colorectal cancer.
Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of ?-Catenin, BRG1, and KDM4.
Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.
Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer.
Gene expression of vascular endothelial growth factor a, thymidylate synthase, and tissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients.
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.
Heterogeneity of metalloproteinase expression in colorectal cancer - relation of molecular findings to basic morphology.
High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer.
Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma.
Matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer.
Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma.
Matrix metalloproteinases 2, 3, 13 and their type 2 tissue inhibitor in tumors and plasma of patients with colorectal cancer.
Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancer.
Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration.
Metastatic and non-metastatic colorectal cancer (CRC) cells induce host metalloproteinase production in vivo.
MicroRNA-191 correlates with poor prognosis of colorectal carcinoma and plays multiple roles by targeting tissue inhibitor of metalloprotease 3.
MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28.
Neoplastic progression of human colorectal cancer is associated with overexpression of the stromelysin-3 and BM-40/SPARC genes.
Netrin-1 plays a role in the effect of moderate exercise on myocardial fibrosis in rats.
Photoactivated Spatiotemporally-Responsive Nanosensors of in Vivo Protease Activity.
Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer.
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma.
Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease.
Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patients.
Simultaneous measurement of soluble carcinoembryonic antigen and the tissue inhibitor of metalloproteinase TIMP1 serum levels for use as markers of pre-invasive to invasive colorectal cancer.
Strong association of tissue inhibitor of metalloproteinase (TIMP)-2 and -3 promoter single nucleotide polymorphisms with risk of colorectal cancer in ethnic Kashmiri population - a case control study.
Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.
TIMP1 intron 3 retention is a marker of colon cancer progression controlled by hnRNPA1.
Unique insight into microenvironmental changes in colorectal cancer: Ex vivo assessment of matrix metalloprotease-mediated molecular changes in human colorectal tumor tissue and corresponding non-neoplastic adjacent tissue.
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group]
[Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer]
Communicable Diseases
Extracellular Matrix Enzymes and Immune Cell Biology.
Cone-Rod Dystrophies
An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9.
Confusion
An evaluation of chromogenic substrates for characterization of serine protease produced by pathogenic Vibrio alginolyticus.
Congenital Abnormalities
Pathogenesis of thrombotic thrombocytopenic purpura.
Connective Tissue Diseases
Engineered Tissue Inhibitor of Metalloproteinases-3 Variants Resistant to Endocytosis Have Prolonged Chondroprotective Activity.
Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature.
Contracture
Mechanical stress in vitro induces increased expression of MMPs 2 and 9 in excised Dupuytren's disease tissue.
Corneal Neovascularization
Delayed neovascularization in inflammation-induced corneal neovascularization in interleukin-10-deficient mice.
Corneal Opacity
Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.
Coronary Artery Disease
ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1.
ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.
Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease.
Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease.
Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease.
Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease.
Do metalloproteinases destabilize vulnerable atherosclerotic plaques?
Metalloproteinase 2 and 9 Activity Increase in Epicardial Adipose Tissue of Patients with Coronary Artery Disease.
Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease.
Protective effect of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 haplotype on coronary artery disease.
Relation of matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio in peripheral circulating CD14+ monocytes to progression of coronary artery disease.
Serum metalloproteinase 9 levels in patients with coronary artery disease: a novel marker of inflammation.
Urinary levels of matrix metalloproteinase 9 and 2 and tissue inhibitor of matrix metalloproteinase in patients with coronary artery disease.
[Activity of inflammatory-destructive changes in the process of formation of unstable atherosclerotic plaque]
[Changes in proinflammatory cytokine and destructive metalloproteinase levels during formation of unstable atherosclerotic plaque]
[Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].
Coronary Disease
Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapy.
Effect of matrix metalloproteinase and their inhibitors on atrial myocardial structural remodeling.
Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation.
Coronary Restenosis
[Batimastat-eluting stent implantation for the treatment of coronary artery disease: results of the Brazilian pilot study]
Coronary Stenosis
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Cough
Effect of Xiaochuanping powder on the inflammatory response and airway remodeling in asthmatic rats.
COVID-19
A Case of COVID-19 Induced Thrombotic Thrombocytopenic Purpura.
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.
Alpha-1-antitrypsin: A possible host protective factor against Covid-19.
Multi-organ damage by covid-19: congestive (cardio-pulmonary) heart failure, and blood-heart barrier leakage.
Potential interactions of SARS-CoV-2 with human cell receptors in the skin: understanding the enigma for a lower frequency of skin lesions compared to other tissues.
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19.
Cowpox
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Craniosynostoses
Cytogenetic and array CGH characterization of de novo 1p36 duplications and deletion in a patient with congenital cataracts, hearing loss, choanal atresia, and mental retardation.
Crohn Disease
Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease.
Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction.
Cystadenocarcinoma, Serous
Tissue and serum metalloproteinase (MMP-2) expression in advanced ovarian serous cystoadenocarcinomas: clinical and prognostic implications.
Cystic Fibrosis
Activity of the lysosomal cysteine proteinases (cathepsin B,H,L) and a metalloproteinase (MMP-7-ase) in the serum of cystic fibrosis homozygous children.
Locally produced relaxin may affect testis and vas deferens function in rats.
Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis.
Cysticercosis
Functionally Expression of Metalloproteinase in Taenia solium Metacestode and Its Evaluation for Serodiagnosis of Cysticercosis.
Cysts
A possible role for metalloproteinases in renal cyst development.
Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts.
Implication of thymoquinone as a remedy for polycystic ovary in rat.
Darier Disease
A case of segmental Darier disease treated with doxycycline monotherapy.
Dementia
Catalytic activity of ADAM28.
Novel role of TGF-beta in differential astrocyte-TIMP-1 regulation: implications for HIV-1-dementia and neuroinflammation.
Dementia, Vascular
Analysis of functional polymorphisms of metalloproteinase genes in persons with vascular dementia and Alzheimer's disease.
Demyelinating Diseases
Matrix metalloproteinases and their tissue inhibitors in cuprizone-induced demyelination and remyelination of brain white and gray matter.
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.
Dengue
Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability.
Dermatitis
Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression.
Dermatitis, Allergic Contact
Inhibition of contact hypersensitivity reaction to picryl chloride: effect of small molecular weight peptidomimetic compounds possessing inhibitory activity against metalloproteinases.
Dermatitis, Contact
Aqueous extract from aerial parts of Artemisia vestita, a traditional Tibetan medicine, reduces contact sensitivity in mice by down-regulating the activation, adhesion and metalloproteinase production of T lymphocytes.
Aqueous extract from rhizoma notopterygii reduces contact sensitivity by inhibiting lymphocyte migration via down-regulating metalloproteinase activity.
Serum concentrations of metalloproteinase 2, metalloproteinase 9 and granzyme B in contact eczema patients.
Diabetes Mellitus
ADAMTS13 and von Willebrand factor concentrations in patients with diabetes mellitus.
Association between Von Willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-Dimer and cystatin C levels with retinopathy in type 1 diabetes mellitus.
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Expression of tissue inhibitor of metalloprotease 3 is reduced in ischemic but not neuropathic ulcers from patients with type 2 diabetes mellitus.
Hyperhomocysteinemic diabetic cardiomyopathy: oxidative stress, remodeling, and endothelial-myocyte uncoupling.
In vitro evaluation of virulence attributes of Candida spp. isolated from patients affected by diabetes mellitus.
Serum type III, IV collagens and TIMP in patients with type II diabetes mellitus.
Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.
The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in chronic periodontitis with type 2 diabetes mellitus.
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
Diabetes Mellitus, Type 1
Association between Von Willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-Dimer and cystatin C levels with retinopathy in type 1 diabetes mellitus.
Associations between advanced glycation endproducts and matrix metalloproteinases and its inhibitor in individuals with type 1 diabetes.
Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study.
Plasma matrix metalloproteinases are associated with incident cardiovascular disease and all-cause mortality in patients with type 1 diabetes: a 12-year follow-up study.
Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 2
A neglected modulator of insulin-degrading enzyme activity and conformation: The pH.
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise.
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme.
Expression of tissue inhibitor of metalloprotease 3 is reduced in ischemic but not neuropathic ulcers from patients with type 2 diabetes mellitus.
FADD Phosphorylation Modulates Blood Glucose Levels by Decreasing the Expression of Insulin-Degrading Enzyme.
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
Insulin-Degrading Enzyme: A Link between Alzheimer's and Type 2 Diabetes Mellitus.
Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes.
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
Monocyte matrix and ADAM metalloproteinase expression in type 2 diabetes after aspirin therapy.
Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.
The expression of a nitric oxide derivative, tissue inhibitors of metalloproteinase-3, and tissue inhibitors of metalloproteinase-4 in chronic periodontitis with type 2 diabetes mellitus.
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.
TIMP3 overexpression in macrophages protects from insulin resistance, adipose inflammation, and nonalcoholic fatty liver disease in mice.
Diabetes, Gestational
Association of Polymorphism rs17576 of the Metalloproteinase 9 Gene with Gestational Diabetes in Euro-Brazilian Pregnant Women.
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Diabetic Foot
The role of matrix metalloproteinases in wound healing.
Diabetic Nephropathies
Anti-inflammatory effects of short-term pioglitazone therapy in men with advanced diabetic nephropathy.
Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.
Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy.
IGF-1 decreases collagen degradation in diabetic NOD mesangial cells: implications for diabetic nephropathy.
Loss of tissue inhibitor of metalloproteinase 3 (TIMP3) selectively exacerbates diabetic nephropathy.
Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians.
Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.
Role of tissue inhibitors of metalloproteinase in diabetic nephropathy.
Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy.
Diabetic Retinopathy
Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion.
Digestive System Neoplasms
Novel role of microRNA-126 in digestive system cancers: From bench to bedside.
Diphtheria
Diphtheria toxin endocytosis and membrane translocation are dependent on the intact membrane-anchored receptor (HB-EGF precursor): studies on the cell-associated receptor cleaved by a metalloprotease in phorbol-ester-treated cells.
Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.
Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways.
Disseminated Intravascular Coagulation
Cloning of a prothrombin activator-like metalloproteinase from the West African saw-scaled viper, Echis ocellatus.
The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation.
Down Syndrome
ADAM12s as a first-trimester screening marker of trisomy.
Can EGCG Alleviate Symptoms of Down Syndrome by Altering Proteolytic Activity?
Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.
Insect Defense Proteins and Peptides.
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Drug Hypersensitivity Syndrome
DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related?
Dry Eye Syndromes
Development towards Compact Nitrocellulose-Based Interferometric Biochips for Dry Eye MMP9 Label-Free In-Situ Diagnosis.
Evaluation of a novel dry eye model induced by oral administration of finasteride.
Dupuytren Contracture
Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease.
The role of an MMP inhibitor in the regulation of mechanical tension by Dupuytren's fibroblasts.
Dyslipidemias
Evaluation of metalloproteinase 2 and 9 levels and their inhibitors in combined dyslipidemia.
Ecchymosis
The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox).
Ectopia Lentis
Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.
Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.
Ehlers-Danlos Syndrome
ADAMTS Proteinases: Potential Therapeutic Targets?
Chronic treatment with a broad-spectrum metalloproteinase inhibitor, doxycycline, prevents the development of spontaneous aortic lesions in a mouse model of vascular ehlers-danlos syndrome.
Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase.
Encephalitis
Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence.
Encephalomyelitis
ADAMTS Proteinases: Potential Therapeutic Targets?
Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis.
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
Encephalomyelitis, Autoimmune, Experimental
Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis.
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
Endometrial Neoplasms
Effects of hepatocyte growth factor on the expression of matrix metalloproteinases and their tissue inhibitors during the endometrial cancer invasion in a three-dimensional coculture.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in uterine endometrial carcinoma and a correlation between expression of matrix metalloproteinase-7 and prognosis.
Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage I and II endometrial cancer.
Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma.
Matrix metalloproteinase (MMP)-2 and MMP-9 Expression in Tumor Infiltrating CD3 Lymphocytes From Women With Endometrial Cancer.
microRNA-103 regulates the growth and invasion of endometrial cancer cells through the downregulation of tissue inhibitor of metalloproteinase 3.
MicroRNA-200b is overexpressed in endometrial adenocarcinomas and enhances MMP2 activity by downregulating TIMP2 in human endometrial cancer cell line HEC-1A cells.
MiR-148b functions as a tumor suppressor by targeting endoplasmic reticulum metallo protease 1 in human endometrial cancer cells.
The association of transforming growth factor-beta 1 with myometrial invasion of endometrial carcinomas through effects on matrix metalloproteinase.
The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer.
[Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma]
Endometrial Stromal Tumors
Pulmonary metastatic lesion of endolymphatic stromal myosis expresses metastasis-related genes but not invasion-related matrix type metalloproteinase.
Endometriosis
Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts.
Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2.
Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems.
Induction of peritoneal endometriosis in nude mice with use of human immortalized endometriosis epithelial and stromal cells: a potential experimental tool to study molecular pathogenesis of endometriosis in humans.
Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathway.
TIMP1 Contributes to Ovarian Anomalies in Both an MMP-Dependent and -Independent Manner in a Rat Model.
[Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 mRNA in endometriosis]
[New medical treatments for painful endometriosis: CNGOF-HAS Endometriosis Guidelines].
Endotoxemia
Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases.
Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia.
The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia.
[Metalloproteinase activity in myocardium of rats exposed to endotoxin and its inhibition with doxycycline]
[The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure].
Enteritis
Global gene expression profiles reveal an increase in mRNA levels of collagens, MMPs, and TIMPs in late radiation enteritis.
Ependymoma
Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas.
Epidermolysis Bullosa
Generalized dominant epidermolysis bullosa simplex: decreased activity of a gelatinolytic protease in cultured fibroblasts as a phenotypic marker.
Epilepsies, Partial
Tetanus neurotoxin-induced epilepsy in mouse visual cortex.
Epilepsy
Different circulating metalloproteinases profiles in women with migraine with and without aura.
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Oxidative stress, metalloproteinase and LDH in children with intractable and non-intractable epilepsy as reflected in salivary analysis.
Epilepsy, Rolandic
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Erythema
A full-UV spectrum absorbing daily use cream protects human skin against biological changes occurring in photoaging.
Effects of the aminophenol analogue p-Dodecylaminophenol on mouse skin.
[Transforming growth factor beta, metalloproteinase 2 and its tissue inhibitor 2 in the serum from patients with early and late boreliosis]
Escherichia coli Infections
Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces.
Esophageal Neoplasms
ADAM10-mediated release of heregulin confers resistance to trastuzumab by activating HER3.
Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis.
Esophageal Squamous Cell Carcinoma
Elevated levels of serum metalloproteinase 9 in patients with esophageal squamous cell carcinoma.
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma.
Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance.
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis.
Immunohistochemical analysis on potential new molecular targets for esophageal cancer.
Methylation of TIMP3 in esophageal squamous cell carcinoma.
Essential Hypertension
Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals.
Exfoliation Syndrome
Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance.
[Loss of heterozygosity at microsatellite marker localised near the metalloproteinase gene in patients with PEX syndrome]
Exotropia
MMPs, TIMPs and BMP-4 in medial rectus muscle obtained from intermittent exotropia patients and their clinical correlations.
Eye Diseases
Identification of differentially expressed genes in keratoconus epithelium analyzed on microarrays.
Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.
Familial Hypophosphatemic Rickets
FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.
The enigma of hyperparathyroidism in hypophosphatemic rickets.
Familial Primary Pulmonary Hypertension
Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension.
Fatty Liver
A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction.
Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome.
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Steatotic liver allografts up-regulate UCP-2 expression and suffer necrosis in rats.
Fetal Alcohol Spectrum Disorders
In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning.
Fetal Growth Retardation
Perigestational alcohol consumption induces altered early placentation and organogenic embryo growth restriction by disruption of trophoblast angiogenic factors.
Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR).
Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology.
Fibromatosis, Aggressive
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Fibrosarcoma
A fibrosarcoma model derived from mouse embryo cells: growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines.
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis.
Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma.
Filamin A controls matrix metalloprotease activity and regulates cell invasion in human fibrosarcoma cells.
Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis.
Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.
Isoginkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrix metalloproteinase-9 expression.
Janus kinase 2 influences growth hormone receptor metalloproteolysis.
Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine.
Release of gelatinase A (matrix metalloproteinase 2) induced by photolysis of caged phosphatidic acid in HT 1080 metastatic fibrosarcoma cells.
Repression of stromelysin metalloprotease expression in rat fibrosarcoma cells by dimethylsulfoxide.
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
Transforming growth factor-beta suppresses the invasiveness of human fibrosarcoma cells in vitro by increasing expression of tissue inhibitor of metalloprotease.
Type IV collagenase activity of a primary HSV-2-induced hamster fibrosarcoma and its in vivo metastases and in vitro clones.
Furunculosis
Innate and adaptive immune responses of Arctic charr (Salvelinus alpinus, L.) during infection with Aeromonas salmonicida subsp. achromogenes and the effect of the AsaP1 toxin.
Gallbladder Neoplasms
Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer.
Gastritis
Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis.
Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.
Production of metalloproteinase in gastric tissue with acetic acid-induced ulcer or taurocholic acid-induced gastritis.
Gastroesophageal Reflux
Expression of metalloproteinase-9 in patients with mild and severe forms of gastroesophageal reflux disease.
Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease.
Gastrointestinal Neoplasms
Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers.
Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer.
Gestational Trophoblastic Disease
Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.
Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases.
Giant Cell Arteritis
Elevated levels of 92-kd type IV collagenase (matrix metalloproteinase 9) in giant cell arteritis.
Giant Cell Tumors
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
[Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone]
Gingivitis
Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.
Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis.
Glaucoma
Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases.
Metalloproteinase 9 and TIMP-1 expression in retina and optic nerve in absolute angle closure glaucoma.
Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance.
Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.
Glaucoma, Angle-Closure
Metalloproteinase 9 and TIMP-1 expression in retina and optic nerve in absolute angle closure glaucoma.
Glaucoma, Open-Angle
Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10.
Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance.
Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.
Glioblastoma
ADAR2/miR-589-3p axis controls glioblastoma cell migration/invasion.
Advances in molecular therapies in patients with brain tumors.
An Extensive Invasive Intracranial Human Glioblastoma Xenograft Model. Role of High Level Matrix Metalloproteinase 9.
Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.
Characterization of a membrane-bound metalloendoprotease of rat C6 glioblastoma cells.
Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification.
Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation.
Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloprotease.
Luteolin reduces migration of human glioblastoma cell lines via inhibition of the p-IGF-1R/PI3K/AKT/mTOR signaling pathway.
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
MiR-145 inhibits the epithelial-to-mesenchymal transition via targeting ADAM19 in human glioblastoma.
Modeling invasion patterns in the glioblastoma battlefield.
Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival.
Protein kinase C activation by phorbol ester increases in vitro invasion through regulation of matrix metalloproteinases/tissue inhibitors of metalloproteinases system in D54 human glioblastoma cells.
Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity.
The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.
Treatment with Gold Nanoparticles Using Cudrania tricuspidata Root Extract Induced Downregulation of MMP-2/-9 and PLD1 and Inhibited the Invasiveness of Human U87 Glioblastoma Cells.
Glioma
A metalloprotease activity from C6 glioma cells inactivates the myelin-associated neurite growth inhibitors and can be neutralized by antibodies.
A metalloproteinase, capable of destroying cultured brain tissue isolated from rat glioma cells.
Advances in molecular therapies in patients with brain tumors.
Anti-invasive effect of an anti-matrix metalloproteinase agent in a murine brain slice model using the serial monitoring of green fluorescent protein-labeled glioma cells.
Apoptotic induction by BE16627B on human malignant glioma cell lines by an anti-matrix metalloproteinase agent.
Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression.
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member.
Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway.
Combination of lithium chloride and pEGFP-N1-BmK CT effectively decreases proliferation and migration of C6 glioma cells.
Deoxypodophyllotoxin inhibits cell viability and invasion by blocking the PI3K/Akt signaling pathway in human glioblastoma cells.
Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity.
Differential activity of bcl-2 and ICE enzyme family protease inhibitors on Fas and puromycin-induced apoptosis of glioma cells.
Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.
Exosome-mediated transfer of MIF confers temozolomide resistance by regulating TIMP3/PI3K/AKT axis in gliomas.
Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors.
Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells.
Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta.
Glioma invasion in vitro: regulation by matrix metalloprotease-2 and protein kinase C.
Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline.
Glioma-derived ADAM10 induces regulatory B cells to suppress CD8+ T cells.
Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion.
Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma.
IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma.
Inflammatory cytokine modulation of matrix metalloproteinase expression and invasiveness of glioma cells in a 3-dimensional collagen matrix.
Inhibition of glioma angiogenesis and invasion by SI-27, an anti-matrix metalloproteinase agent in a rat brain tumor model.
Inhibition of growth and induction of differentiation in a malignant human glioma cell line by normal leptomeningeal extracellular matrix proteins.
Inhibition of MMP14 potentiates the therapeutic effect of temozolomide and radiation in gliomas.
Integration of microfluidic chip with biomimetic hydrogel for 3D controlling and monitoring of cell alignment and migration.
Invasion of brain tissue by primary glioma: evidence for the involvement of urokinase-type plasminogen activator as an activator of type IV collagenase.
Ionizing radiation affects epidermal growth factor receptor signalling and metalloproteinase secretion in glioma cells.
Isolation and characterization of a metalloproteinase secreted by rat glioma cells in serum-free culture.
L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.
Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids.
Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2.
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matter.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
Overexpression of a disintegrin and metalloprotease 8 in human gliomas is implicated in tumor progression and prognosis.
pEGFP-N1-mediated BmK CT expression suppresses the migration of glioma.
Randomized, double-blind, placebo-controlled trial of marimastat in glioblastoma multiforme patients following surgery and irradiation.
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.
Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas.
Spreading and migration of human glioma and rat C6 cells on central nervous system myelin in vitro is correlated with tumor malignancy and involves a metalloproteolytic activity.
Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.
The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase.
The correlation between the expression of ADAM17, EGFR and Ki-67 in malignant gliomas.
Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.
Tracking cell invasion of human glioma cells and suppression by anti-matrix metalloproteinase agent in rodent brain-slice model.
Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
Glomerulonephritis
Circulating levels of matrix metalloproteinases MMP-3 and MMP-2 in renal transplant recipients with chronic transplant nephropathy.
Downregulated expression in high IgA (HIGA) mice and the renal protective role of meprinbeta.
Doxycycline decreases proteinuria in glomerulonephritis.
Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy.
Serial alterations of glomerular matrix-degrading metalloproteinase activity in anti-thymocyte-induced glomerulonephritis in rats.
Glomerulonephritis, IGA
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.
Glomerulonephritis, Membranous
Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy.
Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy.
Glomerulosclerosis, Focal Segmental
Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis.
Glomerular metalloprotease activity modulates the development of focal segmental glomerulosclerosis.
Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy.
Glucose Intolerance
Timp3 deficiency in insulin receptor-haploinsufficient mice promotes diabetes and vascular inflammation via increased TNF-alpha.
Gnathostomiasis
Gnathostoma binucleatum: excretion-secretion antigen analysis obtained from advanced third-stage larvae in in vitro culture.
Graft vs Host Disease
A metalloproteinase inhibitor prevents acute graft-versus-host disease in mice after bone marrow transplantation.
A metalloproteinase inhibitor prevents acute graft-versus-host disease while preserving the graft-versus-leukaemia effect of allogeneic bone marrow transplantation.
A metalloproteinase inhibitor prevents lethal acute graft-versus-host disease in mice.
Granuloma
Cell-matrix interactions modulate interstitial collagenase expression by human keratinocytes actively involved in wound healing.
Expressions of Matrix Metalloproteinases (MMP-2, MMP-7, and MMP-9) and Their Inhibitors (TIMP-1, TIMP-2) in Inflammatory Bowel Diseases.
Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions.
Mycobacteria-induced granuloma necrosis depends on IRF-1.
[Mechanism of the radiolucence around the implant after hip prosthetic replacement]
Hajdu-Cheney Syndrome
Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene.
Mutation of Membrane Type-1 Metalloproteinase, MT1-MMP, Causes the Multicentric Osteolysis and Arthritis Disease Winchester Syndrome.
Head and Neck Neoplasms
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer.
Dynamic contrast-enhanced MRI evaluates the early response of human head and neck tumor xenografts following anti-EMMPRIN therapy with cisplatin or irradiation.
Matrix metalloproteinase 3 polymorphism: a predictive factor of response to neoadjuvant chemotherapy in head and neck squamous cell carcinoma.
Systemic matrix metalloproteinase-8 response in chronic tonsillitis.
Heart Arrest
Thrombotic Thrombocytopenic Purpura: Revisiting a Miss and an Inevitable Consequence.
Heart Defects, Congenital
Plasmatic ADAMTS-13 metalloprotease and von Willebrand factor in children with cyanotic congenital heart disease.
Heart Diseases
Cardiac remodeling and failure From molecules to man (Part II).
Endogenous osteopontin induces myocardial CCL5 and MMP-2 activation that contributes to inflammation and cardiac remodeling in a mouse model of chronic Chagas heart disease.
Fibrosis-Related Gene Expression in Single Ventricle Heart Disease.
Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy.
Synergism between arrhythmia and hyperhomo-cysteinemia in structural heart disease.
Heart Failure
Arrhythmia and neuronal/endothelial myocyte uncoupling in hyperhomocysteinemia.
Can the expression of the metalloproteinase 9 gene and its inhibitor be considered as markers of heart failure?
Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts.
Elevation of plasma atrial natriuretic peptide in rats with chronic heart failure by SCH 39370, a neutral metalloendopeptidase inhibitor.
Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat.
Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy.
Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.
Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure.
Metalloproteinases 2 and 9 are increased in plasma of patients with heart failure.
MMP9 inhibition increases autophagic flux in chronic heart failure.
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding.
Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure.
Relationship of polymorphisms in the tissue inhibitor of metalloproteinase (TIMP)-1 and -2 genes with chronic heart failure.
Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure.
Selective MMP-12 inhibitors: WO-2008057254.
Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients.
Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease.
Synergism between arrhythmia and hyperhomo-cysteinemia in structural heart disease.
[The activity of components of system of matrix metalloproteinase and tissue inhibitors of metalloproteinase on different stages of chronic cardiac failure].
[The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure]
Heart Rupture
Deficiency in TIMP-3 increases cardiac rupture and mortality post-myocardial infarction via EGFR signaling: beneficial effects of cetuximab.
Heart Septal Defects, Ventricular
Essential role for ADAM19 in cardiovascular morphogenesis.
HELLP Syndrome
Mild to moderate reduction of a von Willebrand factor cleaving protease (ADAMTS-13) in pregnant women with HELLP microangiopathic syndrome.
Placental expression of proteases and their inhibitors in patients with HELLP syndrome.
Pregnancy-associated thrombotic thrombocytopenic purpura with anti-centromere antibody-positive Raynaud's Syndrome.
Hemangioma, Cavernous, Central Nervous System
Expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) in cerebral cavernous malformations: immunohistochemical analysis of MMP-2, -9 and TIMP-2.
Hematologic Neoplasms
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
Hemochromatosis
Elevated serum type IV collagen: a sensitive indicator of the presence of cirrhosis in haemochromatosis.
Hemolytic-Uremic Syndrome
Acute kidney injury in Hemiscorpius lepturus scorpion stung children: Risk factors and clinical features.
Clinical experience in treatment of thrombotic thrombocytopenic purpura--hemolytic uremic syndrome with 28 patients.
Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis.
Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases.
Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology.
Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
Thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
[Thrombotic microangiopathy].
Hemophilia B
Development of novel treatment options for patients with haemophilia.
Hemorrhagic Fever with Renal Syndrome
Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia.
Hemorrhagic Fever, Ebola
Functional Genomics Reveals the Induction of Inflammatory Response and Metalloproteinase Gene Expression during Lethal Ebola Virus Infection.
Hemostatic Disorders
Moojenactivase, a novel pro-coagulant PIIId metalloprotease isolated from Bothrops moojeni snake venom, activates coagulation factors II and X and induces tissue factor up-regulation in leukocytes.
Hepatitis
Expression of decorin, transforming growth factor-beta 1, tissue inhibitor metalloproteinase 1 and 2, and type IV collagenases in chronic hepatitis.
Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro.
Serum collagenase activity in patients with chronic liver disease.
[Hepatic fibrosis and its serum markers]
Hepatitis B
Activation of the envelope proteins by a metalloproteinase enables attachment and entry of the hepatitis B virus into T-lymphocyte.
Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.
Hepatitis B, Chronic
Plasma Level of ADAMTS13 or IL-12 as an Indicator of HBeAg Seroconversion in Chronic Hepatitis B Patients Undergoing m-ETV Treatment.
Serum markers for connective tissue turnover in patients with chronic hepatitis B and chronic hepatitis C: a comparative analysis.
Hepatitis C
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Gene polymorphisms of Interleukin 1? and Metalloproteinase 3 in Hepatitis C Infected Patients and Hepatocellular Carcinoma Patients.
Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C.
Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C.
Hepatitis C, Chronic
Effect of pegylated interferon alpha 2b plus ribavirin treatment on plasma transforming growth factor-beta1, metalloproteinase-1, and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis C.
Effects of interferon plus ribavirin treatment on NF-kappaB, TGF-beta1, and metalloproteinase activity in chronic hepatitis C.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients.
Serum markers for connective tissue turnover in patients with chronic hepatitis B and chronic hepatitis C: a comparative analysis.
Hepatitis, Alcoholic
Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis.
Hepatitis, Autoimmune
Stromal TIMP3 Regulates Liver Lymphocyte Populations and Provides Protection against Th1 T Cell-Driven Autoimmune Hepatitis.
Hepatitis, Chronic
Altered pattern of circulating matrix metalloproteinases -2,- 9 and tissue inhibitor of metalloproteinase -2 in patients with HCV-related chronic hepatitis. Relationship to histological features.
Effect of lamivudine treatment on plasma levels of transforming growth factor beta1, tissue inhibitor of metalloproteinases-1 and metalloproteinase-1 in patients with chronic hepatitis B.
Matrix metalloproteinase (MMP)-2, MMP-7, and tissue inhibitor of metalloproteinase-1 are closely related to the fibroproliferative process in the liver during chronic hepatitis C.
Serum collagenase activity in patients with chronic liver disease.
Herpes Simplex
Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence.
Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus.
Type IV collagenase activity of a primary HSV-2-induced hamster fibrosarcoma and its in vivo metastases and in vitro clones.
Ultrasound-targeted HSVtk and Timp3 gene delivery for synergistically enhanced antitumor effects in hepatoma.
Herpes Zoster
A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth.
Anchoring cortical granules in the cortex ensures trafficking to the plasma membrane for post-fertilization exocytosis.
Blast-induced temporal alterations in blood-brain barrier properties in a rodent model.
Cellular and molecular modification of egg envelope hardening in fertilization.
Importance of the Porcine ADAM3 Disintegrin Domain in Sperm-Egg Interaction.
Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida.
Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10).
Mammalian gamete fusion depends on the inhibition of ovastacin by fetuin-B.
Mammalian plasma fetuin-B is a selective inhibitor of ovastacin and meprin metalloproteinases.
Melatonin improves the fertilization ability of post-ovulatory aged mouse oocytes by stabilizing ovastacin and Juno to promote sperm binding and fusion.
Novel proteomic profiling of epididymal extracellular vesicles in the domestic cat reveals proteins related to sequential sperm maturation with differences observed between normospermic and teratospermic individuals.
Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility.
The E-modulus of the oocyte is a non-destructive measure of zona pellucida hardening.
Histiocytoma, Benign Fibrous
Expression of the tissue metalloproteinase inhibitors TIMP-1 and TIMP-2 in malignant fibrous histiocytomas and dermatofibromas as studied by in situ hybridization and immunohistochemistry.
Histiocytoma, Malignant Fibrous
Expression of the tissue metalloproteinase inhibitors TIMP-1 and TIMP-2 in malignant fibrous histiocytomas and dermatofibromas as studied by in situ hybridization and immunohistochemistry.
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Hodgkin Disease
Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma.
Hookworm Infections
Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum.
HTLV-I Infections
Induction of MMP9 (92 kDa gelatinase) activity and expression of tissue inhibitor of metalloproteinase-2 mRNA (TIMP-2) in primitive neuroectodermal cells infected with retrovirus HTLV-I.
Huntington Disease
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Changes in nine enzyme markers for neurons, glia, and endothelial cells in agonal state and Huntington's disease caudate nucleus.
Hyaline Membrane Disease
Gelatinase activities in the airways of premature infants and development of bronchopulmonary dysplasia.
Hydatidiform Mole
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Reduced expression of tissue inhibitor of metalloproteinase (TIMP)-2 in gestational trophoblastic diseases.
[Prediction of malignant transformation of hydatidiform mole by mRNA determination of matrix metalloproteinases and tissue inhibitor of metalloproteinases]
Hydronephrosis
Expression of subunits of the metalloendopeptidase meprin in renal cortex in experimental hydronephrosis.
Hyperalgesia
Effect of the C-terminus of murine S100A9 protein on experimental nociception.
GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.
Inflammatory mediators involved in the paw edema and hyperalgesia induced by Batroxase, a metalloproteinase isolated from Bothrops atrox snake venom.
Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation.
Hyperemia
Leptin induces ovulation in GnRH-deficient mice.
Hyperglycemia
CCN2 protein is an announcing marker for cardiac remodeling following STZ-induced moderate hyperglycemia in mice.
Distinct actions of ETA selective versus combined ETA/ETB receptor antagonists in early diabetic kidney disease.
Review article: diabetes and atherosclerosis--running on a common road.
Hyperhomocysteinemia
Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats.
Hyperlipidemias
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Hyperprolactinemia
Regulation of granulosa cell-derived ovarian metalloproteinase inhibitor(s) by prolactin.
Hypersensitivity
Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
Hypersensitivity, Delayed
Macrophage-migration inhibitory factor: role in inflammatory diseases and graft rejection.
Hypertension
?-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17.
Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
Angiotensin-II induced hypertension and renovascular remodelling in tissue inhibitor of metalloproteinase 2 knockout mice.
Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease.
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Effects of omapatrilat in low, normal, and high renin experimental hypertension.
Endothelin-1 inactivating peptidase in the human kidney and urine.
Evaluation of metalloprotease inhibitors on hypertension and diabetic nephropathy.
Family history of hypertension, anthropometric parameters and markers of early atherosclerosis in young healthy individuals.
Increased Circulating Tissue Inhibitor of Metalloproteinase-2 Is Associated With Resistant Hypertension.
Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.
Matrix metalloproteinase-9 and tissue inhibitor metalloproteinase-1 levels in essential hypertension. Relationship to left ventricular mass and anti-hypertensive therapy.
Metalloendopeptidases EC 3.4.24.15 and EC 3.4.24.16 and bradykinin B2 receptors do not play important roles in renal wrap hypertension in rabbits.
Metalloproteinase inhibition ameliorates hypertension and prevents vascular dysfunction and remodeling in renovascular hypertensive rats.
Metalloproteinase Inhibition Protects against Reductions in Circulating Adrenomedullin during Lead-induced Acute Hypertension.
Oxidative stress and vascular stiffness in hypertension: A renewed interest for antioxidant therapies?
Pharmacokinetic-pharmacodynamic (PK-PD) modeling for a new antihypertensive agent (neutral metalloendopeptidase inhibitor SCH 42354) in patients with mild to moderate hypertension.
Phosphoramidon blocks the pressor activity of big endothelin[1-39] and lowers blood pressure in spontaneously hypertensive rats.
Porto-pulmonary hypertension exacerbated by platelet transfusion in a patient with ADAMTS13 deficiency.
Resistant Hypertension: Is There a Pathophysiologic Role for the Metalloproteinase System?
Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension.
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension.
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice.
Vascular Induction of a Disintegrin and Metalloprotease 17 by Angiotensin II Through Hypoxia Inducible Factor 1?
[Effect of hypotensive therapy on metalloproteinase activity of the blood in patients with arterial hypertension]
[Metalloproteinase activity of the blood in patients with arterial hypertension with paroxysmal form of atrial fibrillation.]
Hypertension, Malignant
Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy.
Hypertension, Portal
ADAMTS13 deficiency, despite well-compensated liver functions in patients with noncirrhotic portal hypertension.
ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension.
Altered von Willebrand Factor and ADAMTS13 Levels in Children With Cirrhosis and Extrahepatic Portal Hypertension.
Plasma ADAMTS-13 protein is not associated with portal hypertension or hemodynamic changes in patients with cirrhosis.
Hypertension, Pregnancy-Induced
Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy.
Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension.
Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.
Hypertension, Pulmonary
ADAMTS8 Promotes the Development of Pulmonary Arterial Hypertension and Right Ventricular Failure: A Possible Novel Therapeutic Target.
Metalloproteinase inhibition by Batimastat attenuates pulmonary hypertension in chronically hypoxic rats.
Hypoglossal Nerve Injuries
A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons.
Hypogonadism
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Hypothyroidism
Neonatal hypothyroidism alters the pattern of prostatic growth and differentiation, as well as plasminogen activator and metalloprotease expression, in the rat.
Idiopathic Pulmonary Fibrosis
Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort.
Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis.
[Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis].
Immune System Diseases
ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice.
Infarction, Middle Cerebral Artery
Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
Infections
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.
A Large-Scale Epidemiological Study to Identify Bacteria Pathogenic to Pacific Oyster Crassostrea gigas and Correlation Between Virulence and Metalloprotease-like Activity.
A metalloprotease produced by larval Schistosoma mansoni facilitates infection establishment and maintenance in the snail host by interfering with immune cell function.
A recombinant metalloprotease antigen of Vibrio vulnificus elicits protective antibodies in a murine model.
A role for matrix metalloproteinases in the pathology and attenuation of Theileria annulata infections.
A single regulatory gene is sufficient to alter Vibrio aestuarianus pathogenicity in oysters.
A type II secreted RNase of Legionella pneumophila facilitates optimal intracellular infection of Hartmannella vermiformis.
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.
An archival case of clinically significant infection in a surgical patient by enterotoxigenic Bacteroides fragilis: PCR amplification of the metalloprotease enterotoxin gene from non-viable lyophilizates.
Ancylostoma ceylanicum metalloprotease 6 DNA vaccination induces partial protection against hookworm challenge infection.
Anthrax lethal factor inhibitors as potential countermeasure of the infection.
Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Bacillus anthracis' Lethal Toxin Induces Broad Transcriptional Responses in Human Peripheral Monocytes.
Bi-layered nanocomposite bandages for controlling microbial infections and overproduction of matrix metalloproteinase activity.
CD13 (human aminopeptidase N) mediates human cytomegalovirus infection.
CD13/aminopeptidase N and murine cytomegalovirus infection.
Characterization of a metalloprotease involved in Vibrio splendidus infection in the sea cucumber, Apostichopus japonicus.
Cloning and sequence analysis of a novel metalloprotease gene from Vibrio parahaemolyticus 04.
Cloning of a metalloprotease gene involved in the virulence mechanism of Vibrio anguillarum.
CMV-infected allogeneic endothelial cells initiate responder and bystander donor HLA class I release via the metalloproteinase cleavage pathway.
Cocktail of gp63 and Hsp70 induces protection against Leishmania donovani in BALB/c mice.
Collagen-based wound dressing for doxycycline delivery: in-vivo evaluation in an infected excisional wound model in rats.
Combining quantitative genetic footprinting and trait enrichment analysis to identify fitness determinants of a bacterial pathogen.
Comparative pathogenicity of a wild-type strain and respiratory mutants of Candida albicans in mice.
Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-?? and ASK1 Pathways.
Detection of elastase from Pseudomonas aeruginosa in sputum and its potential role in epithelial cell permeability.
Detection of Metalloproteases and Cysteine Proteases RNA Transcripts of Leishmania (Leishmania) infantum in Ear Edge Skin of Naturally Infected Dogs.
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus ?-toxin action.
Edwardsiella tarda Sip1: A serum-induced zinc metalloprotease that is essential to serum resistance and host infection.
Effect of PEX, a Noncatalytic Metalloproteinase Fragment with Integrin-Binding Activity, on Experimental Chlamydophila pneumoniae Infection.
Enhancin, the granulosis virus protein that facilitates nucleopolyhedrovirus (NPV) infections, is a metalloprotease.
Enhancing anti-inflammatory cytokine IL-10 may be beneficial for acute coronary syndrome.
Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro.
Evaluation of immunogenicity and protective efficacy of a Microsporum canis metalloprotease subunit vaccine in guinea pigs.
Exceptionally Selective Substrate Targeting by the Metalloprotease Anthrax Lethal Factor.
Expression and characterization of a metalloprotease from a Vibrio parahaemolyticus isolate.
Expression of chemokines and adhesion molecules in human coronary artery endothelial cells infected with Chlamydia (Chlamydophila) pneumoniae.
Expression of the insect metalloproteinase inhibitor IMPI in the fat body of Galleria mellonella exposed to infection with Beauveria bassiana.
Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality.
Fatal hemolytic uremic syndrome associated with day care surgery and anaesthesia: a case report.
Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans.
Genetic rescue of surface metalloproteinase (gp63)-deficiency in Leishmania amazonensis variants increases their infection of macrophages at the early phase.
gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection.
HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis.
How Helicobacter pylori infection controls gastric acid secretion.
Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis.
Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection.
Human Rhinovirus Infection Upregulates MMP-9 Production in Airway Epithelial Cells via NF-{kappa}B.
Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus.
Identification and characterization of putative virulence genes and gene clusters in Aeromonas hydrophila PPD134/91.
Identification of a surface metalloproteinase on 13 species of Leishmania isolated from humans, Crithidia fasciculata, and Herpetomonas samuelpessoai.
Identification of an astacin-like metallo-proteinase transcript from the infective larvae of Strongyloides stercoralis.
In Vitro and In Vivo Characterization of Potent Antileishmanial Methionine Aminopeptidase-1 Inhibitors.
Increased proteolytic activity and matrix metalloprotease expression in lungs during infection by porcine reproductive and respiratory syndrome virus.
Individual matrix metalloproteinases control distinct transcriptional responses in airway epithelial cells infected with Pseudomonas aeruginosa.
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Infection of human astrocytoma cells with simian-human immunodeficiency virus results in up-regulation of gene expression and altered growth properties.
Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.
Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells.
Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group.
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells.
Legionella pneumophila major acid phosphatase and its role in intracellular infection.
Mammalian antimicrobial peptide influences control of cutaneous Leishmania infection.
Management of severe abdominal infections.
Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C.
Matrilysin (matrix metalloproteinase 7) in parturition, premature rupture of membranes, and intrauterine infection.
Matrix metalloprotease inhibitors restore impaired NK cell-mediated antibody-dependent cellular cytotoxicity in human immunodeficiency virus type 1 infection.
Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity.
Measuring virulence factor expression by the pathogenic bacterium Photorhabdus luminescens in culture and during insect infection.
Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease.
Meprin proteolytic complexes at the cell surface and in extracellular spaces.
Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N.
Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7.
Modulation of the Bacillus anthracis secretome by the immune inhibitor A1 protease.
Molecular characterization of protease activity in Serratia sp. strain SCBI and its importance in cytotoxicity and virulence.
Molecular responses of Ostrea edulis haemocytes to an in vitro infection with Bonamia ostreae.
Mouse skin damage caused by a recombinant extracellular metalloprotease from Vibrio vulnificus and by V. vulnificus infection.
Novel Inhibitors Of The Pseudomonas aeruginosa Virulence Factor Pseudolysin/LasB: A Potential Therapeutic Approach For The Attenuation Of Virulence Mechanisms In Pseudomonal Infection.
Paenibacillus larvae metalloprotease production during the infection of honeybee larvae.
Plasma membrane profiling during enterohemorrhagic E. coli infection reveals that the metalloprotease StcE cleaves CD55 from host epithelial surfaces.
Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.
Quorum sensing in Vibrio anguillarum: characterization of the vanI/vanR locus and identification of the autoinducer N-(3-oxodecanoyl)-L-homoserine lactone.
Rapid and efficient one-step purification of a serralysin family protease by using a p-aminobenzamidine-modified affinity medium.
Relief from Zmp1-mediated arrest of phagosome maturation is associated with facilitated presentation and enhanced immunogenicity of mycobacterial antigens.
Rhinovirus upregulates matrix metalloproteinase-2, matrix metalloproteinase-9, and vascular endothelial growth factor expression in nasal polyp fibroblasts.
Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus.
Role of the host cell's unfolded protein response in arenavirus infection.
Soluble donor HLA class I and beta 2m-free heavy chain in serum of lung transplant recipients: steady-state levels and increases in patients with recurrent CMV infection, acute rejection episodes, and poor outcome.
Staphylococcus aureus osteomyelitis: bad to the bone.
Structural insight into the bacterial mucinase StcE essential to adhesion and immune evasion during enterohemorrhagic E. coli infection.
Synthetic peptide substrates for a conductimetric assay of Pseudomonas aeruginosa elastase.
The novel Legionella pneumophila type II secretion substrate NttC contributes to infection of amoebae Hartmannella vermiformis and Willaertia magna.
The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300.
The propeptide of the metalloprotease of Listeria monocytogenes controls compartmentalization of the zymogen during intracellular infection.
The Pseudomonas aeruginosa protease LasB directly activates IL-1?.
The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice.
The therapeutic potential of the insect metalloproteinase inhibitor against infections caused by Pseudomonas aeruginosa.
The type II secretion system of Legionella pneumophila elaborates two aminopeptidases, as well as a metalloprotease that contributes to differential infection among protozoan hosts.
Trichuris suis: thiol protease activity from adult worms.
Use of Zymography in Trypanosomiasis Studies.
Vascular permeability enhancement by Vibrio mimicus protease and the mechanisms of action.
VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.
Vibrio vulnificus infection and metalloprotease.
von Willebrand factor increases in experimental cerebral malaria but is not essential for late-stage pathogenesis in mice.
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
[Detection of Bacteroides fragilis enterotoxin from extraintestinal clinical isolates of B. fragilis group organisms]
Infertility
Could the defects in the endometrial extracellular matrix during the implantation be a cause for impaired fertility?
Infertility, Female
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment.
Inflammatory Bowel Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.
Infliximab restores the dysfunctional matrix remodeling protein and growth factor gene expression in patients with inflammatory bowel disease.
Levels and activities of von Willebrand factor and metalloproteinase with thrombospondin type-1 motif, number 13 in inflammatory bowel diseases.
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease.
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Relationship between Metalloprotease-7 and -14 and Tissue Inhibitor of Metalloprotease 1 Expression by Mucosal Stromal Cells and Colorectal Cancer Development in Inflammatory Bowel Disease.
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease.
Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin ? Inhibitors.
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP.
Influenza, Human
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Extracellular Matrix Proteolysis by MT1-MMP Contributes to Influenza-Related Tissue Damage and Mortality.
Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells.
Matrix metalloprotease 9 mediates neutrophil migration into the airways in response to influenza virus-induced toll-like receptor signaling.
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Insulin Resistance
Heparin-binding EGF-like growth factor (HB-EGF) mediates 5-HT-induced insulin resistance through activation of EGF receptor-ERK1/2-mTOR pathway.
Impaired regulation of the TNF-alpha converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
Inflammatory and metabolic markers and short-time outcome in patients with acute ischemic stroke in relation to TOAST subtypes.
Interleukin 29 activates expression of tissue inhibitor of metalloproteinase 1 in macrophages via toll?like receptor 2.
Markers of remodeling in subcutaneous adipose tissue are strongly associated with overweight and insulin sensitivity in healthy non-obese men.
Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels.
Pattern of expression of inflammatory markers in adipose tissue of untreated hypertensive patients.
Review article: diabetes and atherosclerosis--running on a common road.
The role of metalloproteinases and their tissue inhibitors in adipose tissue remodelling and whole-body lipid distribution: a cross-sectional clinical study.
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.
Intervertebral Disc Degeneration
Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats.
Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation.
Mechanical destabilisation induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration.
Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration.
Minimal invasive annulotomy for induction of disc degeneration and implantation of poly (lactic-co-glycolic acid) (PLGA) plugs for annular repair in a rabbit model.
Resistin Promotes Intervertebral Disc Degeneration by Up-Regulation of ADAMTS-5 Through p38 MAPK Signaling Pathway.
TNF-? and IL-1? promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.
[Effect of electroacupuncture intervention on expression of extracellular matrix collagen and metabolic enzymes].
[Electroacupuncture down-regulates expression of ADAMTS-4 of intervertebral disc in rats with lumbar intervertebral disc degeneration].
[Expression of p16INK4a in nucleus pulposus and its effect on degenerated intervertebral discs].
[Study on yiqi huayu bushen recipe and its disassembled recipes in regulating mRNA expression of collagens and metabolic enzymes in extracellular matrix of cervical disc]
Intestinal Volvulus
Identification and characterization of onchoastacin, an astacin-like metalloproteinase from the filaria Onchocerca volvulus.
Intracranial Aneurysm
Comparative evaluation of genome-wide gene expression profiles in ruptured and unruptured human intracranial aneurysms.
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Differential expression levels of collagen 1A2, tissue inhibitor of metalloproteinase 4, and cathepsin B in intracranial aneurysms.
mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays.
Tissue inhibitor of metalloproteinases-1, -2, and -3 polymorphisms in a white population with intracranial aneurysms.
Intracranial Hemorrhages
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update.
The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations.
Iron Overload
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis.
Ischemic Attack, Transient
Involvement of MMPs in delayed neuronal death after global ischemia.
Ischemic Stroke
ADAMTS-13 Activity Predicts Outcome in Acute Ischaemic Stroke Patients Undergoing Endovascular Treatment.
Association between ADAM17 Promoter Polymorphisms and Ischemic Stroke in a Chinese Population.
Combination treatment with U0126 and rt-PA prevents adverse effects of the delayed rt-PA treatment after acute ischemic stroke.
Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events.
Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis.
Heat shock protein 90 inhibition by 17-Dimethylaminoethylamino-17-demethoxygeldanamycin protects blood-brain barrier integrity in cerebral ischemic stroke.
Matrix metalloproteinase inhibition prevents oxidative stress-associated blood-brain barrier disruption after transient focal cerebral ischemia.
Matrix metalloproteinase-9 contributes to the increase of tau protein in serum during acute ischemic stroke.
MMP-9 and/or TIMP as predictors of ischaemic stroke in patients with symptomatic and asymptomatic atherosclerotic stenosis of carotid artery treated by stenting or endarterectomy - A review.
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
The Value of ADAMTS13 in Predicting Clinical Outcomes in Patients With Acute Ischemic Stroke Receiving Thrombolysis.
Jaw Cysts
Collagenase-3 expression in periapical lesions: an immunohistochemical study.
Job Syndrome
Plasma metalloproteinase levels are dysregulated in signal transducer and activator of transcription 3 mutated hyper-IgE syndrome.
Joint Diseases
Al-Aqeel Sewairi syndrome, a new autosomal recessive disorder with multicentric osteolysis, nodulosis and arthropathy. The first genetic defect of matrix metalloproteinase 2 gene.
Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1?-induced Primary Human Articular Chondrocytes.
Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.
Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors.
Nesfatin-1 suppresses interleukin-1?-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats.
Novel functions of inactive rhomboid proteins in immunity and disease.
Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
The effect of recombinant tumor necrosis factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes.
Keloid
Growth Differentiation Factor-9 Promotes Fibroblast Proliferation and Migration in Keloids through the Smad2/3 Pathway.
Keratitis
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.
The effect of a synthetic metalloproteinase inhibitor on corneal ulceration in alkali burns and pseudomonas keratitis.
Tissue Inhibitor of Metalloproteinase (TIMP) Peptidomimetic as an Adjunctive Therapy for Infectious Keratitis.
Keratoconus
Histopathological findings after intracorneal ring segment implantation in keratoconic human corneas.
Increased gelatinolytic activity in keratoconus keratocyte cultures. A correlation to an altered matrix metalloproteinase-2/tissue inhibitor of metalloproteinase ratio.
Keratoconus corneas: increased gelatinolytic activity appears after modification of inhibitors.
Mutational screening of VSX1, SPARC, SOD1, LOX, and TIMP3 in keratoconus.
Kidney Diseases
ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury.
Decreased expression of matrix metalloproteinases and tissue inhibitors of metalloproteinase in the kidneys of hereditary nephrotic (ICGN) mice.
Key metalloproteinase-mediated pathways in the kidney.
The glomerular proteome in a model of chronic kidney disease.
Kidney Failure, Chronic
Detection of a metalloproteinase in patients with acute and chronic renal failure.
Endothelin-1 inactivating peptidase in the human kidney and urine.
Indoxyl sulfate stimulates renal synthesis of transforming growth factor-beta 1 and progression of renal failure.
Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients.
Proteomic and metabolomic characterization of streptozotocin-induced diabetic nephropathy in TIMP3-deficient mice.
Kidney Neoplasms
Betulinic acid induces apoptosis and inhibits metastasis of human renal carcinoma cells in vitro and in vivo.
MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients.
Laminopathies
Laminopathies: multisystem dystrophy syndromes.
MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies.
Leg Ulcer
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1?, interleukin-1?, interleukin-8 levels and fibroblast activation.
Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers.
Potential role of metalloproteinase inhibitors from radiation?sterilized amnion dressings in the healing of venous leg ulcers.
Legionnaires' Disease
Demonstration of the intracellular production of tissue-destructive protease by Legionella pneumophila multiplying within guinea-pig and human alveolar macrophages.
Zinc metalloprotease ProA of Legionella pneumophila increases alveolar septal thickness in human lung tissue explants by collagen IV degradation.
Leiomyoma
Translational research with progesterone receptor modulator motivated by the use of levonorgestrel-releasing intrauterine system.
Leishmaniasis
Antigen genes for molecular epidemiology of leishmaniasis: polymorphism of cysteine proteinase B and surface metalloprotease glycoprotein 63 in the Leishmania donovani complex.
Mapping human T cell epitopes in leishmania gp63. Identification of cross-reactive and species-specific epitopes.
Leprosy
High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions.
Leukemia
A latent Mr 94,000 gelatin-degrading metalloprotease induced during differentiation of HL-60 promyelocytic leukemia cells: a member of the collagenase family of enzymes.
Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib.
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation.
CD10 expression is useful in the diagnosis of follicular carcinoma and follicular variant of papillary thyroid carcinoma.
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver.
Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Id1 transcription inhibitor-matrix metalloproteinase 9 axis enhances invasiveness of the breakpoint cluster region/abelson tyrosine kinase-transformed leukemia cells.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Leukemic cells (HL-60) produce a novel extracellular matrix-degrading proteinase that is not inhibited by tissue inhibitors of matrix metalloproteinases (TIMPs).
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Morus alba Stem Extract Suppresses Matrix Metalloproteinases (MMP)-1, MMP-9, and Tissue Inhibitors of Metalloproteinase (TIMP)-1 Expression via Inhibition of I?B? Degradation Induced by Porphyromonas gingivalis LPS Signal in THP-1 Cells.
Protein profiling of anastomosed facial nerve treated with mesenchymal stromal cells.
Purification of nasulysin-1: A new toxin from Porthidium nasutum snake venom that specifically induces apoptosis in leukemia cell model through caspase-3 and apoptosis-inducing factor activation.
Soluble beta 2-microglobulin-free class I heavy chains are released from the surface of activated and leukemia cells by a metalloprotease.
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells.
Tumor necrosis factor alpha and lymphotoxin stimulate human myeloblastic leukemia cell (ML-1) invasion through a reconstituted basement membrane (Matrigel) with concomitant induction of 92 kDa gelatinase secretion.
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
[Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.]
[Research progress on mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia].
Leukemia, Hairy Cell
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Leukemia, Lymphocytic, Chronic, B-Cell
Metalloprotease inhibitors block release of soluble CD27 and enhance the immune stimulatory activity of chronic lymphocytic leukemia cells.
Plasma matrix metalloprotease 9 correlates with blood lymphocytosis, leukemic cell invasiveness, and prognosis in B-cell chronic lymphocytic leukemia.
Leukemia, Monocytic, Acute
The essential roles of matrix metalloproteinase-2, membrane type 1 metalloproteinase and tissue inhibitor of metalloproteinase-2 in the invasive capacity of acute monocytic leukemia SHI-1 cells.
[Effect of TIMP-2, MT1-MMP and MMP-2 expression on the in vitro invasive capacity of acute monocytic leukemia SHI-1 cells.]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Leukemia, Myeloid, Acute
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia.
Leukemia, Plasma Cell
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Leukostasis
AKT/NF-kappaB inhibitor xanthohumol targets cell growth and angiogenesis in hematologic malignancies.
Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-kappaB and p53 modulation.
Lichen Planus, Oral
Immunohistochemical and clinical significance of matrix metalloproteinase-2 and its inhibitor in oral lichen planus.
Lipodystrophy
A novel homozygous Ala529Val LMNA mutation in Turkish patients with mandibuloacral dysplasia.
A novel syndrome of mandibular hypoplasia, deafness, and progeroid features associated with lipodystrophy, undescended testes, and male hypogonadism.
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.
Inherited lipodystrophies and hypertriglyceridemia.
Lipodystrophies: Disorders of adipose tissue biology.
Lipodystrophy, Congenital Generalized
Inherited lipodystrophies and hypertriglyceridemia.
Lipodystrophies: Disorders of adipose tissue biology.
Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia.
Lipoma
CD10 (neprilysin) expression: a potential adjunct in the distinction of hibernoma from morphologic mimics.
Listeriosis
Galleria mellonella as a model system for studying Listeria pathogenesis.
Liver Abscess, Amebic
Immunization with the Entamoeba histolytica surface metalloprotease EhMSP-1 protects hamsters from amebic liver abscess.
Liver Cirrhosis
A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.
Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells.
ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma.
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Anti-fibrotic effect of Cordyceps sinensis polysaccharide: Inhibiting HSC activation, TGF-?1/Smad signalling, MMPs and TIMPs.
C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice.
Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats.
Deficiency of BPOZ2 Decreases Liver Fibrosis After Chronic Carbon Tetrachloride Administration in Mice.
Generation and optimization of human antagonistic antibodies against TIMP-1 as potential therapeutic agents in fibrotic diseases.
Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor.
IL-20 and IL-20R1 antibodies protect against liver fibrosis.
Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo.
Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis.
Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.
Plasma ADAMTS-13 protein is not associated with portal hypertension or hemodynamic changes in patients with cirrhosis.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-?1/Smads and PI3K/Akt pathways.
Silencing tissue inhibitors of metalloproteinases (TIMPs) with short interfering RNA reveals a role for TIMP-1 in hepatic stellate cell proliferation.
Suppression of tissue inhibitor of metalloproteinase-1 by recombinant adeno-associated viruses carrying siRNAs in hepatic stellate cells.
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis.
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies.
Transplantation of Human Wharton's Jelly-Derived Stem Cells Alleviates Chemically Induced Liver Fibrosis in Rats.
Tumor necrosis factor-? promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells.
[Clinical usefulness of plasma activities of gelatinase (matrix metalloproteinase-2 and 9) in chronic liver disease]
[Effect of rosiglitazone on metalloproteinase tissue inhibitor-1 in CCl4-induced liver fibrosis in rats.]
[Regulatory effects of Qinggan Huoxue Recipe on matrix metalloproteinases of alcoholic liver fibrosis rats].
[The relationship of serum metalloproteinase with the severity of liver fibrosis and inflammation.]
Liver Diseases
Adeno-Associated Virus Vector Mediated Delivery of the HBV Genome Induces Chronic Hepatitis B Virus Infection and Liver Fibrosis in Mice.
Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome.
Diagnostic potential of circulating TIMP-1 and MMP-2 as markers of liver fibrosis in patients with chronic hepatitis C.
Hepatic expression of A disintegrin and metalloproteinase (ADAM) and ADAMs with thrombospondin motives (ADAM-TS) enzymes in patients with chronic liver diseases.
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases.
Markers of inflammation and fibrosis in alcoholic hepatitis and viral hepatitis C.
Plasma transforming growth factor beta1, metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 in acute viral hepatitis type B.
Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease.
Targeting von Willebrand factor in liver diseases: A novel therapeutic strategy?
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Tissue inhibitor of metalloproteinase is increased in the serum of precirrhotic and cirrhotic alcoholic patients and can serve as a marker of fibrosis.
Liver Diseases, Alcoholic
Serum markers for hepatic fibrosis in alcoholic liver disease: which is the best marker, type III procollagen, type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase?
Liver Neoplasms
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
Transcriptome analysis of PPAR? target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion.
Lung Diseases
Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis.
Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Polymorphisms of the ADAM33 gene and Chronic Obstructive Pulmonary Disease Risk: a Meta-Analysis.
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis.
Lung Diseases, Interstitial
c-Kit immunophenotyping and metalloproteinase expression profiles of mast cells in interstitial lung diseases.
Lung Diseases, Obstructive
Curcumin attenuates liver warm ischemia and reperfusion-induced combined restrictive and obstructive lung disease by reducing matrix metalloprotease 9 activity.
Functional Studies of Single-Nucleotide Polymorphisms Suggest Heterogeneity in Chronic Obstructive Pulmonary Disease due to Susceptibility of Different Cell Types.
Lung Injury
Hypertonic Saline (NaCl 7.5 %) Reduces LPS-Induced Acute Lung Injury in Rats.
Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat.
Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats.
Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury.
Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice.
[Study on effect of dexamethasone on the expression of matrix metalloproteinase and its tissue inhibitors in hyperoxia-induced lung injury]
Lung Neoplasms
Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.
AE-941 (AEterna).
Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer.
Angiogenesis inhibitors in the treatment of lung cancer.
Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
CCAAT enhancer binding protein-beta regulates matrix metalloproteinase-1 expression in interleukin-1beta-stimulated A549 lung carcinoma cells.
CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration.
Cerebral ischemic events in patients with advanced lung or prostate cancer.
Changes in angiogenic growth factor levels after gefitinib treatment in non-small cell lung cancer.
Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells.
Combined RNAi targeting human Stat3 and ADAM9 as gene therapy for non-small cell lung cancer.
Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.
Cryptotanshinone inhibits lung cancer invasion via microRNA-133a/matrix metalloproteinase 14 regulation.
Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers.
Differential Expressions Of Matrix Metalloproteinases, A Disintegrin And Metalloproteinases, And A Disintegrin And Metalloproteinases With Thrombospondin Motifs And Their Endogenous Inhibitors Among Histologic Subtypes Of Lung Cancers.
Dual role of SnoN in mammalian tumorigenesis.
Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
Elevated serum levels of type I collagen degradation marker ICTP and tissue inhibitor of metalloproteinase (TIMP) 1 are associated with poor prognosis in lung cancer.
Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer.
Evaluation of Pregnancy-Associated Plasma Protein-A Levels in Patients with Chronic Obstructive Pulmonary Disease and Associations with Disease Severity.
Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non-Small Cell Lung Cancer.
Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.
Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor associated dendritic cells by expressing HB-EGF.
Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.
Plasma metalloproteinase activity is enhanced in the euglobulin fraction of breast and lung cancer patients.
Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.
Protective effects of ADAM8 against cisplatin-mediated apoptosis in non-small-cell lung cancer.
Relevance of matrix metalloproteases in non-small cell lung cancer diagnosis.
RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
Serum matrix metalloproteinases -2, -9 and tissue inhibitors of metalloproteinases -1, -2 in lung cancer--TIMP-1 as a prognostic marker.
Serum tissue inhibitors of metalloproteinase-1 and -2 in patients with non-small cell lung cancer.
The relationship of metalloproteinase gene polymorphisms and lung cancer.
The use of mixed collagen-Matrigel matrices of increasing complexity recapitulates the biphasic role of cell adhesion in cancer cell migration: ECM sensing, remodeling and forces at the leading edge of cancer invasion.
Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.
Video-assisted thoracic surgery lobectomy for lung cancer is associated with less immunochemokine disturbances than thoracotomy.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
[The serum concentration of metalloproteinase 9 and 2 in non-small cell lung cancer patients]
Lupus Erythematosus, Systemic
ADAMTS-13 metalloprotease abnormalities in systemic lupus erythematosus: is there a correlation with disease status?
Increased expression of ADAMTS13 mRNA correlates with ischemic cerebrovascular disease in systemic lupus erythematosus patients.
Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA1-Me-pro with two metalloprotease active centers.
Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA2-Me-pro-ChTr possessing two different activities-trypsin-like and metalloprotease.
Systemic lupus erythematosus: possible localization of trypsin-like and metalloprotease active centers in the protein sequence of the monoclonal light chain (NGTA2-Me-pro-Tr).
Lupus Nephritis
Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice.
Effect of a specific endothelin A receptor antagonist on murine lupus nephritis.
Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis.
Novel functions of inactive rhomboid proteins in immunity and disease.
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages.
Lyme Disease
Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis.
Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
[Transforming growth factor beta, metalloproteinase 2 and its tissue inhibitor 2 in the serum from patients with early and late boreliosis]
Lymphadenitis
Comment on "Fibroblasts in Nodular SclerosingClassical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury" Cancers 2019, 11, 1687.
Lymphangioleiomyomatosis
Doxycycline use in patients with lymphangioleiomyomatosis: safety and efficacy in metalloproteinase blockade.
Lymphatic Metastasis
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Contribution of MMP2 Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan.
Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining.
Lymphocytosis
Plasma matrix metalloprotease 9 correlates with blood lymphocytosis, leukemic cell invasiveness, and prognosis in B-cell chronic lymphocytic leukemia.
Lymphoma
Alpinetin inhibits proliferation and migration of ovarian cancer cells via suppression of STAT3 signaling.
CD10 expression is useful in the diagnosis of follicular carcinoma and follicular variant of papillary thyroid carcinoma.
Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies.
Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse.
Expression of anaplastic lymphoma kinase, tyrosine-phosphorylated STAT3, and associated factors in pediatric anaplastic large cell lymphoma: A report from the children's oncology group.
Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas.
Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.
Metalloproteinase inhibition augments antitumor efficacy of the anti-CD30 immunotoxin Ki-3(scFv)-ETA' against human lymphomas in vivo.
Punicalagin suppresses the proliferation and invasion of cervical cancer cells through inhibition of the ?-catenin pathway.
Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.
Relevance of radiobiological concepts in radionuclide therapy of cancer.
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis.
Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas.
VEGF and MMP-9: biomarkers for canine lymphoma.
[Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.]
[Metalloproteinase (MMP-1, 2 and 11), tissue inhibitor of metalloproteinase-1 (TIMP-1), and p53 expression in nasal-type angiocentric T/NK-cell lymphoma: an immunohistochemical study]
Lymphoma, B-Cell
Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Evaluation of extracellular matrix protein expression and apoptosis in the uterosacral ligaments of patients with or without pelvic organ prolapse.
Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes.
MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3.
Tissue inhibitor of metalloproteinase-1 alters the tumorigenicity of Burkitt's lymphoma via divergent effects on tumor growth and angiogenesis.
[Anti-sense miRNA-21 oligonucleotide inhibits Tb 3.1 human tongue squamous cell carcinoma growth in vitro.]
Lymphoma, Large-Cell, Anaplastic
Expression of anaplastic lymphoma kinase, tyrosine-phosphorylated STAT3, and associated factors in pediatric anaplastic large cell lymphoma: A report from the children's oncology group.
Lymphoma, Large-Cell, Immunoblastic
Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.
Lymphoma, Mantle-Cell
Relevance of radiobiological concepts in radionuclide therapy of cancer.
Lymphoma, Non-Hodgkin
Relevance of radiobiological concepts in radionuclide therapy of cancer.
Macular Degeneration
AG-3340 (Agouron Pharmaceuticals Inc).
Age-dependent variation in metalloproteinase activity of isolated human Bruch's membrane and choroid.
Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion.
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy.
Increased pro-MMP9 plasma levels are associated with neovascular age-related macular degeneration and with the risk allele of rs142450006 near MMP9.
Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane.
[Prevention and treatment of age-related macular degeneration by extract of Fructus lycii and its constituents lutein/zeaxanthin: an in vive and in vitro experimental research].
Macular Edema
Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy.
Malaria
A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast.
A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance.
Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule.
Computer modeling of small heat-shock metalloprotease of the human malaria parasite Plasmodium vivax.
Effect of metalloprotease inhibitors on invasion of red blood cell by Plasmodium falciparum.
Functional characterization of Anopheles matrix metalloprotease 1 reveals its agonistic role during sporogonic development of malaria parasites.
Metalloprotease activity in a small heat shock protein of the human malaria parasite Plasmodium vivax.
Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.
Malaria, Cerebral
Association of ADAMTS13 polymorphism with cerebral malaria.
Phagocytosis of haemozoin (malarial pigment) enhances metalloproteinase-9 activity in human adherent monocytes: role of IL-1beta and 15-HETE.
Marfan Syndrome
Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome.
Mastitis
Increase in milk metalloproteinase activity and vascular permeability in bovine endotoxin-induced and naturally occurring Escherichia coli mastitis.
Mastocytoma
Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
Medulloblastoma
Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors.
Medulloblastoma displays distinct regional matrix metalloprotease expression.
Prognostic and clinical implication of a disintegrin and metalloprotease 8 expression in pediatric medulloblastoma.
The invasiveness of five medulloblastoma cell lines in collagen gels.
Melanoma
1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation.
A natural bacterial-derived product, the metalloprotease arazyme, inhibits metastatic murine melanoma by inducing MMP-8 cross-reactive antibodies.
A specific sequence of the noncollagenous domain of the alpha3(IV) chain of type IV collagen inhibits expression and activation of matrix metalloproteinases by tumor cells.
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma.
Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.
Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion.
Anti-metastatic activity of curcumin and catechin.
Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors.
Artemisinin reduces human melanoma cell migration by down-regulating alphaVbeta3 integrin and reducing metalloproteinase 2 production.
Autocrine secretion of Fas ligand shields tumor cells from Fas-mediated killing by cytotoxic lymphocytes.
CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression.
Cilengitide downmodulates invasiveness and vasculogenic mimicry of neuropilin 1 expressing melanoma cells through the inhibition of ?v?5 integrin.
Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.
Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma.
Cytochrome P450 17 (CYP17) Is Involved in Endometrial Cancinogenesis Through Apoptosis and Invasion Pathways.
Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas.
Deletion of ADAM-9 in HGF/CDK4 mice impairs melanoma development and metastasis.
Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.
Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression.
Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability.
Downregulation of reversion-inducing cysteine-rich protein with Kazal motifs in malignant melanoma: inverse correlation with membrane-type 1-matrix metalloproteinase and tissue inhibitor of metalloproteinase 2.
EMMPRIN/CD147 is an independent prognostic biomarker in cutaneous melanoma.
Envelope-targeted retrovirus vectors transduce melanoma xenografts but not spleen or liver.
Gelatinolytic metalloproteinase secretion patterns in ocular melanoma.
Human melanoma-reactive CD4+ and CD8+ CTL clones resist Fas ligand-induced apoptosis and use Fas/Fas ligand-independent mechanisms for tumor killing.
Hyaluronan fragments induce cytokine and metalloprotease upregulation in human melanoma cells in part by signalling via TLR4.
Inhibition of melanoma cells tumorigenicity by the snake venom toxin jararhagin.
Involvement of tumor cell integrin alpha v beta 3 in hematogenous metastasis of human melanoma cells.
Irradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivo.
Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers.
Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA.
Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism.
Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles.
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Modulation of extracellular matrix/adhesion molecule expression by BRG1 is associated with increased melanoma invasiveness.
Mutational and Functional Analysis Reveals ADAMTS18 Metalloproteinase as a Novel Driver in Melanoma.
Overexpression of tissue inhibitors of metalloproteinase 2 up-regulates NF-kappaB activity in melanoma cells.
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.
Potentiated antitumor effects of interleukin 12 and matrix metalloproteinase inhibitor batimastat against B16F10 melanoma in mice.
Pregnancy associated plasma protein-A links pregnancy and melanoma progression by promoting cellular migration and invasion.
Protein Tyrosine Phosphatase 4A3 (PTP4A3) Promotes Human Uveal Melanoma Aggressiveness Through Membrane Accumulation of Matrix Metalloproteinase 14 (MMP14).
Purification and characterization of a connective-tissue-degrading metalloproteinase from the cytosol of metastatic melanoma cells.
Quantitative Proteomics Links the Intermediate Filament Nestin to Resistance to Targeted BRAF Inhibition in Melanoma Cells.
Recombinant interferon alpha and gamma modulate the invasive potential of human melanoma in vitro.
RNA-interference-mediated downregulation of Pin1 suppresses tumorigenicity of malignant melanoma A375 cells.
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.
Stromal collagenase in melanoma: a vascular connection.
Tandem duplication. A novel type of triplet repeat instability.
Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.
The alternatively spliced RECK transcript variant 3 is a predictor of poor survival for melanoma patients being upregulated in aggressive cell lines and modulating MMP gene expression in vitro.
The anti cancer activity of organotelluranes: potential role in integrin inactivation.
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs.
The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis.
The tetraspanin CD81 protein increases melanoma cell motility by up-regulating metalloproteinase MT1-MMP expression through the pro-oncogenic Akt-dependent Sp1 activation signaling pathways.
Tissue inhibitor of metalloproteinase 2 inhibits activation of the ?-catenin signaling in melanoma cells.
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.
Variability in melanoma metalloproteinase expression profiling.
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation.
Melanoma, Experimental
Glioblastoma infiltration into central nervous system tissue in vitro: involvement of a metalloprotease.
Meningioma
Gene Expression of Matrix Metalloproteinases and their Inhibitors (TIMPs) in Meningiomas of Dogs.
Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene Is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas.
Matrix metalloproteinases in human gliomas: activation of matrix metalloproteinase-2 (MMP-2) may be correlated with membrane-type-1 matrix metalloproteinase (MT1-MMP) expression.
The Effect of Matrix Metalloproteinase-3 on the Prognosis and Biological Behaviour of Meningiomas.
Meningitis
Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children.
Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis.
Meningitis, Bacterial
Advances in adjuvant therapy against acute bacterial meningitis.
Gelatinase B [matrix metalloproteinase (MMP)-9] and collagenases (MMP-8/-13) are upregulated in cerebrospinal fluid during aseptic and bacterial meningitis in children.
Meningitis, Pneumococcal
Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems.
Mesothelioma
The interaction of tenascin-C with fibronectin modulates the migration and specific metalloprotease activity in human mesothelioma cell lines of different histotype.
Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma.
Mesothelioma, Malignant
Expression of matrix metalloproteinases, tissue inhibitors of metalloproteinase, collagens, and Ki67 antigen in pleural malignant mesothelioma: an immunohistochemical and electron microscopic study.
Inhibition of proliferation, migration, and matrix metalloprotease production in malignant mesothelioma cells by tyrosine kinase inhibitors.
Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors.
Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma.
Metabolic Diseases
Serum haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complex as a biomarker of systemic inflammation in cattle.
Transcriptional regulation of matrix metalloprotease gene expression in health and disease.
Metabolic Syndrome
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice.
ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice.
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome.
Implications of ADAM17 activation for hyperglycaemia, obesity and type 2 diabetes.
Increased plasma activity of metalloproteinase 2 in women with metabolic syndrome.
Metalloproteinases and leptin in vehicle drivers of public service with metabolic syndrome in Armenia, Quindío.
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of Endothelial PAI-1.
Metrorrhagia
Differential elevation of matrix metalloproteinase expression in women exposed to levonorgestrel-releasing intrauterine system for a short or prolonged period of time.
Microphthalmos
Targeting the hedgehog transcription factors GLI1 and GLI2 restores sensitivity to vemurafenib-resistant human melanoma cells.
Migraine Disorders
Different circulating metalloproteinases profiles in women with migraine with and without aura.
Serum elastase activity is elevated in migraine.
Mixed Connective Tissue Disease
Serum levels of tissue inhibitor of metalloproteinases in patients with mixed connective tissue disease.
Monoclonal Gammopathy of Undetermined Significance
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Mouth Diseases
In vitro and in vivo studies of the Yrp1 protease from Yersinia ruckeri and its role in protective immunity against enteric red mouth disease of salmonids.
Mouth Neoplasms
A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain.
Acetylshikonin suppresses invasion of Porphyromonas gingivalis?infected YD10B oral cancer cells by modulating the interleukin-8/matrix metalloproteinase axis.
Contribution of MMP2 Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan.
Involvement of the A disintegrin and metalloproteinase 9 in oral cancer cell invasion.
Moyamoya Disease
Single nucleotide polymorphisms of tissue inhibitor of metalloproteinase genes in familial moyamoya disease.
Single nucleotide polymorphisms of tissue inhibitors of metalloproteinase genes in familial moyamoya disease.
The GC?+?CC genotype at position -418 in TIMP-2 promoter and the -1575GA/-1306CC genotype in MMP-2 is genetic predisposing factors for prevalence of moyamoya disease.
Mucocutaneous Lymph Node Syndrome
Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population.
Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease.
Mucositis
Matrix metalloproteinases are possible mediators for the development of alimentary tract mucositis in the dark agouti rat.
Multiple Myeloma
Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Size variants of beta-2-microglobulin-free human leucocyte antigen class I heavy chain make different contributions to its serum increase in multiple myeloma.
[Standard treatment of multiple myeloma]
Multiple Sclerosis
Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophase phagocytic activities.
Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases.
Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.
Interferon beta treatment: bioavailability and antiviral activity in multiple sclerosis patients.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Matrix metalloproteinase-7 facilitates immune access to the CNS in experimental autoimmune encephalomyelitis.
Misuse of serum matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloproteinase (TIMP)-1 as a biomarker in multiple sclerosis.
PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions.
Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage.
Relationship between metalloproteinase 2 and 9 concentrations and soluble CD154 expression in Iranian patients with multiple sclerosis.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
Muscle Cramp
Cationic antimicrobial peptides serve as activation signals for the Salmonella Typhimurium PhoPQ and PmrAB regulons in vitro and in vivo.
Muscular Dystrophies
Animal models for muscular dystrophy; mechanism of disease and potential therapy.
Muscular Dystrophy, Duchenne
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.
Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy.
Fibroblasts from the muscles of Duchenne muscular dystrophy patients are resistant to cell detachment apoptosis.
Mycoses
Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease.
RNAi-mediated suppression of insect metalloprotease inhibitor (IMPI) enhances Galleria mellonella susceptibility to fungal infection.
Myelodysplastic Syndromes
Biological and clinical relevance of matrix metalloproteinases 2 and 9 in acute myeloid leukaemias and myelodysplastic syndromes.
Myocardial Infarction
A prospective evaluation of left ventricular remodeling after inaugural anterior myocardial infarction as a function of gene polymorphisms in the renin-angiotensin-aldosterone, adrenergic, and metalloproteinase systems.
Activity of cathepsin H,B and metalloproteinase in the serum of patients with acute myocardial infarction.
Association of polymorphisms of zinc metalloproteinases with clinical response to stem cell therapy.
Cardiac tissue inhibitor of matrix metalloprotease 4 dictates cardiomyocyte contractility and differentiation of embryonic stem cells into cardiomyocytes: Road to therapy.
Cardioprotective Effects of Metalloproteinase Inhibitor 1-({4-[(4-Chlorobenzoyl)amino]phenyl}sulfonyl-L-Proline in Modeled Acute Myocardial Infarction.
Do metalloproteinases destabilize vulnerable atherosclerotic plaques?
Downregulation of microRNA-21-5p from macrophages-derived exosomes represses ventricular remodeling after myocardial infarction via inhibiting tissue inhibitors of metalloproteinase 3.
Dynamic expression of the main related indicators of thrombosis, inflammatory reaction and tissue damage in a rat model of myocardial infarction.
Early short-term treatment with doxycycline modulates postinfarction left ventricular remodeling.
Effect of Acute Myocardial Infarction on a Disintegrin and Metalloprotease with Thrombospondin Motif 13 and Von Willebrand Factor and Their Relationship with Markers of Inflammation.
Effect of metalloproteinase inhibitor on early postinfarction remodeling in the most acute phase of myocardial infarction.
Effects of metoprolol treatment on a disintegrin metalloproteinase expression and extracellular matrix remodeling after myocardial infarction in rats.
Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis.
Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack.
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
Mechanisms Involved in the Beneficial Effects of Spironolactone after Myocardial Infarction.
Metalloproteinase 2 cleaves in vitro recombinant TRAIL: Potential implications for the decreased serum levels of TRAIL after acute myocardial infarction.
Metalloproteinase production from macrophages - a perfect storm leading to atherosclerotic plaque rupture and myocardial infarction.
Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
MMP9 inhibition increases autophagic flux in chronic heart failure.
Molecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow.
Multiple-polymorphism associations of 7 matrix metalloproteinase and tissue inhibitor metalloproteinase genes with myocardial infarction and angiographic coronary artery disease.
Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis.
Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction.
Plasma monitoring of the myocardial specific tissue inhibitor of metalloproteinase-4 after alcohol septal ablation in hypertrophic obstructive cardiomyopathy.
Prognostic value of tissue inhibitor of metalloproteinase-matrix metalloproteinase biomarkers at 30 days in patients with acute myocardial infarction without reperfusion therapy.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study.
The role of von Willebrand factor and ADAMTS13 in the no-reflow phenomenon: after primary percutaneous coronary intervention.
Usefulness of plasma tissue inhibitors of metalloproteinases as markers of prognosis after acute myocardial infarction.
[In vivo interleukin-10 gene transfer down-regulates myocardial matrix metalloproteinase and myocardial collagen expressions in rats with acute myocardial infarction]
Myocardial Ischemia
Dystrophin and metalloproteinase 9 in myocardial ischemia: A post-mortem immunohistochemical study.
New aspects on angiotensin-converting enzyme: from gene to disease.
Myopia
Changes of TGF-?2, MMP-2, and TIMP-2 levels in the vitreous of patients with high myopia.
Increased latent gelatinase activity in the sclera of visually deprived chicks.
Systematic investigation of the relationship between high myopia and polymorphisms of the MMP2, TIMP2 and TIMP3 genes by a DNA pooling approach.
Myotoxicity
Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis.
nadph dehydrogenase deficiency
Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.
Nasal Polyps
A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability.
Double-stranded RNA poly(I:C) enhances matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells.
Expression of a disintegrin and metalloproteinase 8 by inflammatory cells in nasal polyps.
[Effects of double-stranded RNA poly(I:C) on matrix metalloproteinase mRNA expression in human nasal polyp epithelial cells]
Nasopharyngeal Carcinoma
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis.
Nasopharyngeal Neoplasms
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.
Necrobiotic Disorders
Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor.
Neoplasm Metastasis
A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma.
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
ADAM-9 expression in intestinal-type adenocarcinoma of the sinonasal tract.
ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling.
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis.
ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.
Antisense IL-10 abrogates the inhibitory effects of IL-10 production by transfected tumor cells.
Ardipusilloside inhibits survival, invasion and metastasis of human hepatocellular carcinoma cells.
Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-?/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer.
Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells.
Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis.
Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma.
Association of E-cadherin, matrix metalloproteinases, and tissue inhibitors of metalloproteinases with the progression and metastasis of hepatocellular carcinoma.
Association of high level of serum M(r) approximately 92,000 metalloproteinase activity with lung metastasis of rat 13,762 NF mammary adenocarcinoma.
ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Biochemical and functional characterization of Bothropoidin: the first haemorrhagic metalloproteinase from Bothrops pauloensis snake venom.
Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer.
Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator.
Cancer genetics and cell and molecular biology. Is this the way forward?
Casein kinase 1 (CK1) promotes the proliferation and metastasis of glioma cells via the phosphatidylinositol 3 kinase-matrix metalloproteinase 2 (AKT-MMP2) pathway.
Cassia tora L. (Jue-ming-zi) has anticancer activity in TCA8113 cells in vitro and exerts anti-metastatic effects in vivo.
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Cdc25A Regulates Matrix Metalloprotease 1 through Foxo1 and Mediates Metastasis of Breast Cancer Cells.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Chemokine (C-X-C motif) receptor 4 RNA interference inhibits bone metastasis in breast cancer.
Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol.
Cinnamic acid: a natural product with potential use in cancer intervention.
Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.
Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma.
Clinical significance of matrix metalloproteinase-2 in endometrial cancer: A systematic review and meta-analysis.
Contribution of MMP2 Promoter Genotypes to Oral Cancer Susceptibility, Recurrence and Metastasis in Taiwan.
Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy.
Cytokines related to MMP-11 expression by inflammatory cells and breast cancer metastasis.
Cytotoxic Effects of Ferula Latisecta on Human Glioma U87 Cells.
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.
Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells.
Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms.
Differential gene expression during multistage carcinogenesis.
Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression.
Dissociation Kinetics of an Enzyme-Inhibitor System Using Single-Molecule Force Measurements.
Domain structure of human 72-kDa gelatinase/type IV collagenase. Characterization of proteolytic activity and identification of the tissue inhibitor of metalloproteinase-2 (TIMP-2) binding regions.
Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients.
Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression.
Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability.
Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
Dual inhibition of cMET and EGFR by microRNA-338-5p suppresses metastasis of esophageal squamous cell carcinoma.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Effects of thrombin/thrombosis in angiogenesis and tumour progression.
EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases.
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
EMMPRIN/CD147 is an independent prognostic biomarker in cutaneous melanoma.
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
ERR? signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.
Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction.
Evolutionary aspects of human cancer.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Expression of collagenase IV (basement membrane collagenase) activity in murine tumor cell hybrids that differ in metastatic potential.
Expression of human recombinant 72 kDa gelatinase and tissue inhibitor of metalloproteinase-2 (TIMP-2): characterization of complex and free enzyme.
Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma.
Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis.
Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma.
EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway.
Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome.
Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1.
Genetic Heterogeneity of Breast Cancer Metastasis May Be Related to miR-21 Regulation of TIMP-3 in Translation.
Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma.
Granulocyte colony-stimulating factor (G-CSF)-mediated signaling regulates type IV collagenase activity in head and neck cancer cells.
Growth factors in progression of human esophageal and gastric carcinomas.
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
High metalloproteinase inhibitor content of human cirrhosis and its possible conference of metastasis resistance.
Histone acetylation and gastrointestinal carcinogenesis.
Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells.
Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Premetastatic Niche in Colorectal Cancer.
Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma.
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis.
In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe.
Incorporation of biologic therapies in the management of gastroesophageal cancers.
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat.
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Inhibition of ADAMTS1 Expression by Lentiviral CRISPR/Cas9 Gene Editing Technology.
Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.
Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.
Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloproteinases.
Inhibition of metalloproteinase activity by fruit extracts.
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids.
Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor.
Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4.
Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals.
KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells.
Loss of the metastatic phenotype by a human epidermoid carcinoma cell line, HEp-3, is accompanied by increased expression of tissue inhibitor of metalloproteinase 2.
Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2.
Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury.
Matrix metalloproteinase-7 expression in gastric carcinoma.
Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.
Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion.
Mechanisms of cellular invasiveness: a comparison of amnion invasion in vitro and metastatic behavior in vivo.
Melatonin indirectly decreases gastric cancer cell proliferation and invasion via effects on cancer-associated fibroblasts.
Melatonin maximizes the therapeutic potential of non-preconditioned MSCs in a DEN-induced rat model of HCC.
Metalloproteinase domain structure, cellular invasion and metastasis.
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
Metastasis is strongly reduced by the matrix metalloproteinase inhibitor Galardin in the MMTV-PymT transgenic breast cancer model.
Metastasis-associated gene MAPK15 promotes the migration and invasion of osteosarcoma cells via the c-Jun/MMPs pathway.
Metastatic human hepatocellular carcinoma models in nude mice and cell line with metastatic potential.
Microenvironment-induced TIMP2 loss by cancer-secreted exosomal miR-4443 promotes liver metastasis of breast cancer.
MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma.
miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.
MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2.
MMP-2, TIMP-2 and CD44v6 Expression in Non-small-cell Lung Carcinomas.
MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation.
MMP9 gene expression regulation by intragenic epigenetic modifications in breast cancer.
Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture.
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.
N-glycosylation regulates ADAM8 processing and activation.
Necuparanib, A Multitargeting Heparan Sulfate Mimetic, Targets Tumor and Stromal Compartments in Pancreatic Cancer.
Neuropeptides induce Mr 92,000 type IV collagenase (matrix metalloprotease-9) activity in human prostate cancer cell lines.
New directions for radiation biology research in cancer of the uterine cervix.
Non-destructive and selective imaging of the functionally active, pro-invasive membrane type-1 matrix metalloproteinase (MT1-MMP) enzyme in cancer cells.
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).
Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone.
Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma.
Overview of matrix metalloproteinase expression in cultured human cells.
Patients with hepatic breast cancer metastases demonstrate highly specific profiles of matrix metalloproteinases MMP-2 and MMP-9 after SIRT treatment as compared to other primary and secondary liver tumours.
PAX2 Regulates ADAM10 Expression and Mediates Anchorage-Independent Cell Growth of Melanoma Cells.
Polychlorinated Biphenyl Quinones Promotes Breast Cancer Metastasis through Reactive Oxygen Species-Mediated Nuclear Factor ?B-Matrix Metalloproteinase Signaling.
Possible pathophysiological role of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in metastatic brain tumor-associated intracerebral hemorrhage.
Preclinical assessment of anti-cancer therapeutic strategies using in vivo videomicroscopy.
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
Prognostic value of matrix metalloproteinase-2 (MMP-2) expression in endometrial endometrioid adenocarcinoma.
Proteolysis in colorectal cancer.
Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review).
Purification and analysis of growth regulating proteins secreted by a human melanoma cell line.
Raf kinase inhibitor protein inhibits cholangiocarcinoma cell metastasis by downregulating matrix metalloproteinase 9 and upregulating tissue inhibitor of metalloproteinase 4 expression.
Randomised double blind placebo control study of adjuvant treatment with the metalloproteinase inhibitor, Marimastat in patients with inoperable colorectal hepatic metastases: significant survival advantage in patients with musculoskeletal side-effects.
Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype.
Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms.
Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer.
Regulation of the Mr 72,000 type IV collagenase by the type I insulin-like growth factor receptor.
Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts.
Resveratrol-mediated ADAM9 degradation decreases cancer progression and provides synergistic effects in combination with chemotherapy.
Retroviral delivery of TIMP-2 inhibits H-ras-induced migration and invasion in MCF10A human breast epithelial cells.
Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion.
RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.
Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis.
SETD3 is regulated by a couple of microRNAs and plays opposing roles in proliferation and metastasis of hepatocellular carcinoma.
siRNA mediated inhibition of MMP-1 reduces invasive potential of a human chondrosarcoma cell line.
SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas.
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression.
Spontaneous metastasis in congenic mice with transgenic breast cancer is unaffected by plasminogen gene ablation.
Squalene deters drivers of RCC disease progression beyond VHL status.
Stimulation of the 92-kD type IV collagenase promoter and enzyme expression in human melanoma cells.
Stromal collagenase in melanoma: a vascular connection.
Stromelysin in tumor progression and metastasis.
Structure, regulatory factors and cancer-related physiological effects of ADAM9.
Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling.
Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model.
Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis.
Thalidomide combined with irradiation alters the activity of two proteases.
The 72-kDa metalloproteinase immunostaining in cervical carcinoma: relationship with lymph nodal involvement.
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
The chemokine receptor CXCR4 and the metalloproteinase MT1-MMP are mutually required during melanoma metastasis to lungs.
The effect of a DNA repair gene on cellular invasiveness: XRCC3 over-expression in breast cancer cells.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis.
The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining.
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
The role of the carbohydrates in plasmatic membrane.
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression.
The roles of ARHGAP10 in the proliferation, migration and invasion of lung cancer cells.
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.
Tissue inhibitor of metalloproteinase 2 (TIMP-2) expression in adenocarcinoma pleural effusions.
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
TPX2 silencing mediated by joint action of microvesicles and ultrasonic radiation inhibits the migration and invasion of SKOV3 cells.
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form.
Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase.
Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis.
Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma.
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.
Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1.
YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.
ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.
Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
[Expression and pathological mechanism of MMP-9 and HIF-2? in CD133(+) lung cancer stem cells].
[Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma]
[Localization and expression of matrix metalloproteinase-7 in human prostate]
[Molecular biology studies on metalloproteinase and tissue inhibitor of metalloproteinase expression in salivary adenoid cystic carcinoma]
[New prognostic factors in human gastric carcinomas]
[Relationship between tissue inhibitors of metalloproteinase and metastasis and prognosis in breast cancer]
[Relationship of expression unbalance of matrix metalloproteinase and tissue inhibitor of metalloproteinase to invasiveness and metastasis in gastric carcinomas]
[Roles of matrix metalloproteinases and tissue inhibitor of metalloproteinase (TIMP) in cancer invasion and metastasis]
[Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer]
[Study of matrix metalloproteinase-2 and -9 in thyroid papillary cancer]
Neoplasms
4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-? and regulating the expression of insulin signal transduction proteins.
92-kd gelatinase is actively expressed by eosinophils and stored by neutrophils in squamous cell carcinoma.
?3GnT8 Regulates Laryngeal Carcinoma Cell Proliferation Via Targeting MMPs/TIMPs and TGF-?1.
A cancer cell metalloprotease triad regulates the basement membrane transmigration program.
A Case-Control Study of Comparison of Plasma Levels of Matrix Metalloproteinase-9 in Inhaled Opium Addicts and Clinically Healthy Persons.
A combined microfluidic-transcriptomic approach to characterize the extravasation potential of cancer cells.
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis.
A comparison of the inflammatory potential of particulates derived from two composite materials.
A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression.
A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis.
A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients.
A disintegrin and metalloproteinase 17 regulates TNF and TNFR1 levels in inflammation and liver regeneration in mice.
A disintegrin and metalloproteinase 9 is involved in ectodomain shedding of receptor-binding cancer antigen expressed on SiSo cells.
A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹?F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.
A fibrosarcoma model derived from mouse embryo cells: growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines.
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis.
A knock-down cell-based study for the functional analysis of chloride intracellular channel 1 (CLIC1): Integrated proteomics and microarray study.
A matrix metalloproteinase expressed on the surface of invasive tumour cells.
A metalloproteinase inhibitor blocks the shedding of soluble cytokine receptors and processing of transmembrane cytokine precursors in human monocytic cells.
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.
A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease.
A novel link between FMR gene and the JNK pathway provides clues to possible role in malignant pleural mesothelioma.
A novel orthotopic mouse model of head and neck cancer and lymph node metastasis.
A Novel TNF-? Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice.
A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential.
A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer.
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
A preliminary study: is fibulin 1 a friend or an enemy that needs to be silenced with siRNAs for mesothelioma?
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation.
A substrate-optimized electrophoretic mobility shift assay for ADAM12.
A switch from stromal to tumor cell expression of stromelysin-1 mRNA associated with the conversion of squamous to spindle carcinomas during mouse skin tumor progression.
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.
A zinc metalloproteinase is responsible for the release of CD30 on human tumor cell lines.
A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma.
Abl Interactor 1 Regulates Src-Id1-Matrix Metalloproteinase 9 Axis and Is Required for Invadopodia Formation, Extracellular Matrix Degradation, and Tumor Growth of Human Breast Cancer Cells.
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain.
Activation of fibroblast collagenase-1 expression by tumor cells of squamous cell carcinomas is mediated by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase-2.
Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis.
Active-MMP2 in cancer cell nests of oral cancer patients: correlation with lymph node metastasis.
Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours.
ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with ?v?6 integrin.
ADAM-10 and ADAM-17 in the inflamed human CNS.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
ADAM-9 expression in intestinal-type adenocarcinoma of the sinonasal tract.
ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.
ADAM10 promotes pituitary adenoma cell migration by regulating cleavage of CD44 and L1.
ADAM10 Site-Dependent Biology: Keeping Control of a Pervasive Protease.
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling.
ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity.
ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins.
ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice.
ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer.
ADAM17 as a therapeutic target in multiple diseases.
ADAM17 at the interface between inflammation and autoimmunity.
ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes.
ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical carcinoma.
ADAM17 mediates MMP9 expression in lung epithelial cells.
ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer.
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma.
ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling.
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis.
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.
ADAM9 decreases in castration resistant prostate cancer and is a prognostic factor for overall survival.
ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer.
ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas.
ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype.
ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression.
ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-?B Pathway.
ADAMs family members as amyloid precursor protein alpha-secretases.
ADAMs: focus on the protease domain.
ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells.
ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-18 in the host tissues exerts little effect on breast tumor progress in a murine 4T1 breast cancer model.
ADAMTS-18: a metalloproteinase with multiple functions.
ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma.
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4.
ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-?B Pathway in Human Gastric Cancer.
ADAMTS1: a matrix metalloprotease with angioinhibitory properties.
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer.
ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma.
ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells.
ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer.
Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy.
AG-3340 (Agouron Pharmaceuticals Inc).
Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats.
Age-dependent stimulatory effect of desipramine and fluoxetine pretreatment on metastasis formation by B16F10 melanoma in male C57BL/6 mice.
Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases.
Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production.
Allogenic Pure Platelet-Rich Plasma Therapy for Adhesive Capsulitis: A Bed-to-Bench Study With Propensity Score Matching Using a Corticosteroid Control Group.
Altered Gene and Protein Expressions in Torn Rotator Cuff Tendon Tissues in Diabetic Patients.
Altered Protein Composition and Gene Expression in Strabismic Human Extraocular Muscles and Tendons.
Altered transcriptional regulation of human interstitial collagenase in cultured skin fibroblasts from older donors.
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.
Alternative splicing of ALCAM enables tunable regulation of cell-cell adhesion through differential proteolysis.
Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer.
Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells.
An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.
An extracellular proteasome-like structure from C6 astrocytoma cells with serine collagenase IV activity and metallo-dependent activity on alpha-casein and beta-insulin.
An in vivo model for screening peptidomimetic inhibitors of gelatinase A.
An Integrated In Silico Approach for the Structural and Functional Exploration of Lipocalin 2 and its Functional Insights with Metalloproteinase 9 and Lipoprotein Receptor-Related Protein 2.
An orthotopic floor-of-mouth cancer model allows quantification of tumor invasion.
An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells.
An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention.
Analysis of ADAM9 regulation and function in vestibular schwannoma primary cells.
Analysis of prostate cancer by proteomics using tissue specimens.
Analysis of the cell membrane proteolytic enzymes of the B16, F1, F10, and BL6 melanoma and their role in target cell destruction.
Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1.
Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines.
Antagonistic Effects of Anti-EMMPRIN Antibody When Combined with Chemotherapy Against Hypovascular Pancreatic Cancers.
Anthrax toxin: pathologic effects on the cardiovascular system.
Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma.
Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNF alpha processing.
Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer.
Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.
Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis.
Antiinvasive effects of Tiazofurin on liver-metastatic human colon carcinoma xenografts.
Antiproliferative effect of the jararhagin toxin on B16F10 murine melanoma.
Antiprotease therapy in cancer: hot or not?
Antisense IL-10 abrogates the inhibitory effects of IL-10 production by transfected tumor cells.
Antitumor efficacy of AG3340 associated with maintenance of minimum effective plasma concentrations and not total daily dose, exposure or peak plasma concentrations.
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Apelin Effects Migration and Invasion Abilities of Colon Cancer Cells.
Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-?/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer.
Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-?.
Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.
Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis.
Association of bone loss with the upregulation of survival-related genes and concomitant downregulation of Mammalian target of rapamycin and osteoblast differentiation-related genes in the peripheral blood of late postmenopausal osteoporotic women.
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Asthma susceptible genes in Chinese population: a meta-analysis.
Astragaloside IV inhibits pathological functions of gastric cancer-associated fibroblasts.
ATAT1/MEC-17 acetyltransferase and HDAC6 deacetylase control a balance of acetylation of alpha-tubulin and cortactin and regulate MT1-MMP trafficking and breast tumor cell invasion.
ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter.
Attenuation of increased secretory leukocyte protease inhibitor, matricellular proteins and angiotensin II and left ventricular remodeling by candesartan and omapatrilat during healing after reperfused myocardial infarction.
Autocrine factor enhancing the secretion of M(r) 95,000 gelatinase (matrix metalloproteinase 9) in serum-free medium conditioned with murine metastatic colon carcinoma cells.
Autocrine secretion of Fas ligand shields tumor cells from Fas-mediated killing by cytotoxic lymphocytes.
BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Basigin/EMMPRIN/CD147 mediates neuron-glia interactions in the optic lamina of Drosophila.
Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding.
Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors.
Beneficial influence of microsatellite instability on gelatinase-tissue inhibitors of metalloproteinase balance in colorectal cancer.
Biochemical and functional characterization of Bothropoidin: the first haemorrhagic metalloproteinase from Bothrops pauloensis snake venom.
Biochemical characterization and N-terminomics analysis of leukolysin, the membrane-type 6 matrix metalloprotease (MMP25): chemokine and vimentin cleavages enhance cell migration and macrophase phagocytic activities.
Biochemical mechanisms of tumor invasion and metastases.
Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer.
Biological response modifiers: current use and future prospects in cancer therapy.
Biomarkers for diagnosing and monitoring autoimmune diseases.
Bone morphogenetic protein-7 antagonizes tumor necrosis factor-?-induced activation of nuclear factor ?B and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II.
Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine?disrupting chemicals.
Breast tumor cells transendothelial migration induces endothelial cell anoikis through extracellular matrix degradation.
Broad antitumor and antiangiogenic activities of AG3340, a potent and selective MMP inhibitor undergoing advanced oncology clinical trials.
Cadmium stimulates metastasis-associated phenotype in triple-negative breast cancer cells through integrin and ?-catenin signaling.
Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts.
Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator.
Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure?
Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.
Cancer-Microenvironment-Sensitive Activatable Quantum Dot Probe in the Second Near-Infrared Window.
Canine mammary tumors as a model for human disease.
Cardiovascular benefits of vitamin D.
Cassia tora L. (Jue-ming-zi) has anticancer activity in TCA8113 cells in vitro and exerts anti-metastatic effects in vivo.
Catalytic properties of ADAM12 and its domain deletion mutants.
Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-? in hepatocytes requires activation of Src and the NADPH oxidase NOX1.
CCL20 Stimulates Proinflammatory Mediator Synthesis in Human Fibroblast-like Synoviocytes Through a MAP Kinase-dependent Process with Transcriptional and Posttranscriptional Control.
CD10 expression in pancreatic endocrine tumors: correlation with prognostic factors and survival.
CD10 is a key enzyme involved in the activation of tumor-activated peptide prodrug CPI-0004Na and novel analogues: implications for the design of novel peptide prodrugs for the therapy of CD10+ tumors.
CD10 is frequently expressed in classical seminomas.
CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration.
Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation.
Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type.
Cell-surface Metalloprotease ADAM12 is Internalized by a Clathrin- and Grb2-dependent Mechanism.
Cell-surface MMP-9 regulates the invasive capacity of leukemia blast cells with monocytic features.
Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/GP96.
Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury.
Cellular prion protein coupling to TACE-dependent TNF-alpha shedding controls neurotransmitter catabolism in neuronal cells.
Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression.
Cerebral ischemic events in patients with advanced lung or prostate cancer.
Cetirizine a histamine H1 receptor antagonist improves viral myocarditis.
Changes in biochemical parameters after anterior cruciate ligament injury.
Changes in tissue metalloproteinase inhibitor-1 and matrix metalloproteinases during tumor development and metastasizing in mice.
Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells.
Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma.
Characterization of gelatin-degrading metalloproteinase activities of the Dunning rat prostate tumor grown in nude mice.
Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase.
Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays.
Chemical design of a radiolabeled gelatinase inhibitor peptide for the imaging of gelatinase activity in tumors.
Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse.
Cinnamic acid: a natural product with potential use in cancer intervention.
Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts.
Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients.
Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients.
Clinical Characteristics of Rheumatoid Arthritis Patients Achieving Functional Remission with Six Months of Biological DMARDs Treatment.
Clinical potential of matrix metalloprotease inhibitors in cancer therapy.
Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.
Clinical relevance of serum levels of matrix metallopeptidase-2, and tissue inhibitor of metalloproteinase-1 and -2 in patients with malignant melanoma.
Clinical significance of ADAM10 expression in laryngeal carcinoma.
Clinical significance of matrix metalloproteinase-2 in endometrial cancer: A systematic review and meta-analysis.
Clinical significance of the content of biomolecular markers in invasive front of colon carcinomas.
Clinical significance of tissue inhibitor of metalloproteinase expression in gastric carcinoma.
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Collagenase 3 (matrix metalloproteinase 13) gene expression by HaCaT keratinocytes is enhanced by tumor necrosis factor alpha and transforming growth factor beta.
Combination cancer chemotherapy with one compound: pluripotent bradykinin antagonists.
Combination of Fish Oil and Selenium Enhances Anticancer Efficacy and Targets Multiple Signaling Pathways in Anti-VEGF Agent Treated-TNBC Tumor-Bearing Mice.
Combined Radiochemotherapy: Metalloproteinases Revisited.
Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo.
Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions.
Comparative molecular genetic profiles of anaplastic astrocytomas/glioblastomas multiforme and their subsequent recurrences.
Comparative study of MMP-2 (matrix metalloproteinase 2) immune expression in normal uterine cervix, intraepithelial neoplasias, and squamous cells cervical carcinoma.
Comparison of metalloproteinase protein and activity profiling.
Comparison of the inflammatory response to particulate polymethylmethacrylate debris with and without barium sulfate.
Comparison of the paracrine activity of mesenchymal stem cells derived from human umbilical cord, amniotic membrane and adipose tissue.
Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form.
Constitutive expression and secretion of proteases in non-metastatic SP1 mammary carcinoma cells and its metastatic sublines.
Constitutive production of parathyroid hormone-related protein (PTHrP) by fibroblasts derived from normal and pathological human breast tissue.
Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.
Control of ADAM17 activity by regulation of its cellular localisation.
Cooperative effects of aminopeptidase N (CD13) expressed by nonmalignant and cancer cells within the tumor microenvironment.
Copy number profiling of tumor suppressor genes in head and neck cancer.
Correlation between genetic and biological aspects in primary non-metastatic breast cancers and corresponding synchronous axillary lymph node metastasis.
Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs.
Correlation of Synovial Fluid Biomarkers With Cartilage Pathology and Associated Outcomes in Knee Arthroscopy.
Correspondence re: N-B. Liabakk et al., matrix metalloprotease 2 (MMP-2) and matrix metalloprotease 9 (MMP-9) type IV collagenases in colorectal cancer. Cancer Res., 56: 190-196, 1966.
Crebanine, an aporphine alkaloid, sensitizes TNF-?-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-?B-regulated gene products.
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.
Cross-domain inhibition of TACE ectodomain.
Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains.
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model.
CXCL16 Is Expressed in Podocytes and Acts as a Scavenger Receptor for Oxidized Low-Density Lipoprotein.
Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme.
Cyclosporin A enhances cytokine and phorbol ester-induced fibroblast collagenase expression.
CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study.
Cytokine regulation of gelatinase production by head and neck squamous cell carcinoma: the role of tumor necrosis factor-alpha.
Cytokine regulation of the matrix metalloproteinases and their inhibitors in human papillomavirus-18 transformed human prostatic tumor cell lines.
Cytokine signalling by gp130 regulates gastric mucosal healing after ulceration and, indirectly, antral tumour progression.
Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.
Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.
Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients.
Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas.
Decreased MMP1 gene expression in acute myeloid leukaemia.
Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis.
Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene.
Degradation of fibronectin fibrils by matrilysin and characterization of the degradation products.
Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme.
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.
Design strategies for the identification of MMP-13 and Tace inhibitors.
Design, characterization, and evaluation of peptide arrays allowing the direct monitoring of MMP activities.
Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.
Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity.
Detection of viral infections by in situ PCR: theoretical considerations and possible value in diagnostic pathology.
Development of recombinant adenoviruses that drive high level expression of the human metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 and -2 genes: characterization of their infection into rabbit smooth muscle cells and human MCF-7 adenocarcinoma cells.
Developmental expression of MMP-9 (gelatinase B) mRNA in mouse embryos.
Dietary fat increases solid tumor growth and metastasis of 4T1 murine mammary carcinoma cells, and mortality in obesity-resistant BALB/c mice.
Dietary Fat Stimulates Pancreatic Cancer Growth and Promotes Fibrosis of the Tumor Microenvironment through the Cholecystokinin Receptor.
Differences in expression of metalloproteinases and plasminogen activators in murine melanocytes and B16 melanoma variants: lack of association with in vitro invasion.
Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats.
Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area.
Differential effects of dexamethasone and rosiglitazone in a sephadex-induced model of lung inflammation in rats: possible role of tissue inhibitor of metalloproteinase-3.
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression.
Differential gene expression during multistage carcinogenesis.
Differential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophils.
Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells.
Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.
Differing effects of endogenous and synthetic inhibitors of metalloproteinases on intestinal tumorigenesis.
Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli.
Discovery and Optimization of Selective Inhibitors of Meprin ? (Part II).
Dissociation Kinetics of an Enzyme-Inhibitor System Using Single-Molecule Force Measurements.
DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells.
Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2.
Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients.
Downregulation of Integrins in Cancer Cells and Anti-Platelet Properties Are Involved in Holothurian Glycosaminoglycan-Mediated Disruption of the Interaction of Cancer Cells and Platelets in Hematogenous Metastasis.
Downregulation of reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) is associated with enhanced expression of matrix metalloproteinases and cholangiocarcinoma metastases.
DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia.
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors.
Dual stromelysin-3 function during natural mouse mammary tumor virus-ras tumor progression.
Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction.
E-cadherin and metalloproteinase-1 and -7 polymorphisms in colorectal cancer.
Early GalNAc O-Glycosylation: Pushing the Tumor Boundaries.
Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Effect of Chinese drugs for activating blood circulation and detoxifying on indices of thrombosis, inflammatory reaction, and tissue damage in a rabbit model of toxin-heat and blood stasis syndrome.
Effect of doxycycline and meloxicam on cytokines, brain-derived neurotrophic factor, matrix metalloproteinase-3, tissue inhibitor of metalloproteinase-3 and cyclooxygenase-2 in brain.
Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation.
Effect of hypoxia on angiogenesis related factors in glioblastoma cells.
Effect of phorbol ester and cytokines on matrix metalloproteinase and tissue inhibitor of metalloproteinase expression in tumor and normal cell lines.
Effect of polymerized-type I collagen in knee osteoarthritis. I. In vitro study.
Effect of Tacrolimus on Myocardial Infarction Is Associated with Inflammation, ROS, MAP Kinase and Akt Pathways in Mini-Pigs.
Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
Effect of tumor necrosis factor-alpha converting enzyme (TACE) and metalloprotease inhibitor on amyloid precursor protein metabolism in human neurons.
Effects of ADAM10 and ADAM17 Inhibitors on Natural Killer Cell Expansion and Antibody-dependent Cellular Cytotoxicity Against Breast Cancer Cells
Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation.
Effects of carvedilol or amlodipine on target organ damage in L-NAME hypertensive rats: their relationship with blood pressure variability.
Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.
Effects of hepatocyte growth factor on the expression of matrix metalloproteinases and their tissue inhibitors during the endometrial cancer invasion in a three-dimensional coculture.
Effects of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth.
Effects of particulate debris on macrophage-dependent fibroblast stimulation in coculture.
Effects of phospholipase A2 and metalloprotease fractions of Russell's viper venom on cytokines and renal hemodynamics in dogs.
Effects of sulfasalazine and its metabolites on steady state messenger RNA concentrations for inflammatory cytokines, matrix metalloproteinases, and tissue inhibitors of metalloproteinase in rheumatoid synovial fibroblasts.
Effects of thrombin/thrombosis in angiogenesis and tumour progression.
Effects of vitamin D3 on proliferation of cancer cells in vitro.
Efficacy of dendrimer-mediated angiostatin and TIMP-2 gene delivery on inhibition of tumor growth and angiogenesis: in vitro and in vivo studies.
Efficient purification of TIMP-2 from culture medium conditioned by human hepatoma cell line, and its inhibitory effects on metalloproteinases and in vitro tumor invasion.
EGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.
eIF-4E expression and its role in malignancies and metastases.
Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway.
Elevated levels of circulating plasma matrix metalloproteinase 9 in non-small cell lung cancer patients.
Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization.
Elevated synovial fluid levels of interleukin-6 and tumor necrosis factor associated with early experimental canine osteoarthritis.
Elevated tissue inhibitor of metalloproteinase 1 RNA in colorectal cancer stroma correlates with lymph node and distant metastases.
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions.
Engagement of CD44 promotes Rac activation and CD44 cleavage during tumor cell migration.
Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-alpha-converting enzyme.
Engineering of TIMP-3 as a LAP-fusion protein for targeting to sites of inflammation.
Enhanced activity of meprin-?, a pro-migratory and pro-angiogenic protease, in colorectal cancer.
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.
Enhancement of the surface expression of tumor necrosis factor alpha (TNFalpha) but not the p55 TNFalpha receptor in the THP-1 monocytic cell line by matrix metalloprotease inhibitors.
Ensnaring membrane type 1-matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase (TIMP)-2 using the haemopexin domain of the protease as a carrier: a targeted approach in cancer inhibition.
Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer.
Epigallocatechin-3-gallate Increases RXR?-mediated Pro-apoptotic and Anti-invasive Effects in Gastrointestinal Cancer Cell Lines.
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of ?-Catenin, BRG1, and KDM4.
Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis.
Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma.
Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.
ERR? signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells.
Erratum to: Cancer progression by breast tumors with Pit-1-overexpression is blocked by inhibition of metalloproteinase (MMP)-13.
Escherichia coli lipopolysaccharide potentiation and inhibition of rat neonatal microglia superoxide anion generation: correlation with prior lactic dehydrogenase, nitric oxide, tumor necrosis factor-alpha, thromboxane B2, and metalloprotease release.
Estrogen-deficient osteoporosis enhances the recruitment and activity of osteoclasts by breast cancer cells.
Evaluating the effects of cardiac resynchronization therapy on pathophysiological pathways of heart failure using surrogate biomarkers.
Evaluation of a novel dry eye model induced by oral administration of finasteride.
Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction.
Evidence that elastase is the TNF-R75 shedding enzyme in resting human polymorphonuclear leukocytes.
Exploiting changes in the tumour microenvironment with sequential cytokine and matrix metalloprotease inhibitor treatment in a murine breast cancer model.
Expression and inhibition of ADAMDEC1 in craniopharyngioma cells.
Expression and localization of matrix-degrading metalloproteinases during colorectal tumorigenesis.
Expression and prognostic significance of metalloproteases and their inhibitors in luminal A and basal-like phenotypes of breast carcinoma.
Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis.
Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer.
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Expression of ADAMTS4 in Ewing's sarcoma.
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Expression of collagenase-related metalloproteinase genes in human lung or head and neck tumours.
Expression of emmprin by oral squamous cell carcinoma.
Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma.
Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinase-1 in tongue squamous cell carcinoma.
Expression of matrix metalloproteinase 2 (MMP-2), membrane-type 1 MMP and tissue inhibitor of metalloproteinase 2 and activation of proMMP-2 in pancreatic duct adenocarcinomas in hamsters treated with N-nitrosobis(2-oxopropyl)amine.
Expression of matrix metalloproteinase genes in transformed rat cell lines of high and low metastatic potential.
Expression of matrix metalloproteinase, tissue inhibitors of metalloproteinase and adhesion molecules in silicotic mice with lung tumor metastasis.
Expression of matrix metalloproteinase-2 (MMP-2) and of membrane-type-1-matrix metalloproteinase (MT1-MMP) in transitional cell carcinoma of the upper urinary tract.
Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas.
Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in reactive and neoplastic lymphoid cells.
Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies.
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularization.
Expression of membrane type 1 matrix metalloproteinase in medullary thyroid carcinoma: Prognostic implications.
Expression of membrane type 1 matrix metalloproteinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in human cartilaginous tumors with special emphasis on mesenchymal and dedifferentiated chondrosarcoma.
Expression of membrane-type 1 matrix metalloproteinase (MT1-MMP) on prostate cancer cell lines.
Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas.
Expression of metalloproteinases and their tissue inhibitors in squamous cell laryngeal carcinoma.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma.
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
Expression of stromelysin 3 in the stromal elements of human basal cell carcinoma.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Expression of the PAX8/PPAR? Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis.
Expression of timp-1, timp-2, 72-kda and 92-kda type-iv collagenase transcripts in human astrocytoma cell-lines - correlation with astrocytoma cell invasiveness.
Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis.
Expression of vascular endothelial growth factor related to 72-kilodalton metalloproteinase immunostaining in patients with serous ovarian tumors.
Expression pattern of a gene for a secreted metalloproteinase during late stages of tumor progression.
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Expression profiles associated with aggressive behavior in Merkel cell carcinoma.
Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome.
Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis.
Extracellular matrix metalloprotease inducer stimulates fibroblast-mediated tumor growth in vivo.
Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis.
Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.
Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes.
Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase.
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Fibroblast Growth Factor Receptor Mediates Fibroblast-Dependent Growth in EMMPRIN-Depleted Head and Neck Cancer Tumor Cells.
Fibroblast-directed expression and localization of 92-kDa type IV collagenase along the tumor-stroma interface in an in vitro three-dimensional model of human squamous cell carcinoma.
Flow cytometric analysis of gelatinase B (MMP-9) activity using immobilized fluorescent substrate on microspheres.
Frequent loss of TIMP-3 expression in progression of esophageal and gastric adenocarcinomas.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Function of alpha3beta1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2).
Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis.
Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme.
Functional Characterization of Colon-Cancer-Associated Variants in ADAM17 Affecting the Catalytic Domain.
Gelatin-degrading type IV collagenase isolated from human small cell lung cancer.
Gelatinase B (MMP-9) production and expression by stromal cells in the normal and adult thymus and experimental thymic lymphoma.
Gelatinase B (MMP-9), but not its inhibitor (TIMP-1), dictates the growth rate of experimental thymic lymphoma.
Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression.
Gene and protein localisation of tumour necrosis factor (TNF)-? converting enzyme in gingival tissues from periodontitis patients with drug-induced gingival overgrowth.
Gene expression of interstitial collagenase (matrix metalloproteinase 1) in gastrointestinal tract cancers.
Gene expression profiling of colorectal adenomas and early invasive carcinomas by cDNA array analysis.
Genome-Wide Expression Profiling Reveals EBV-Associated Inhibition of MHC Class I Expression in Nasopharyngeal Carcinoma.
Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome.
Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-?B signaling pathway and activation of Akt signaling pathway.
Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.
Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.
Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-?B signaling pathway in vivo and in vitro.
Growth factors in progression of human esophageal and gastric carcinomas.
HDLs activate ADAM17-dependent shedding.
Hepatic ischemia/reperfusion injury is prevented by a novel matrix metalloproteinase inhibitor, ONO-4817.
Hepatitis C virus induced tumor initiating cancer stem-like cells activate stromal fibroblasts in xenograft tumor model.
Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study.
Herbal compound "Songyou Yin" reinforced the ability of interferon-alfa to inhibit the enhanced metastatic potential induced by palliative resection of hepatocellular carcinoma in nude mice.
Heterozygosity of stromelysin-1 (rs3025058) promoter polymorphism is associated with gastric cancer.
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
High metalloproteinase inhibitor content of human cirrhosis and its possible conference of metastasis resistance.
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells.
High-fat Diet Enhances Mammary Tumorigenesis and Pulmonary Metastasis and Alters Inflammatory and Angiogenic Profiles in MMTV-PyMT Mice.
Higher expression of epidermal growth factor receptor is associated with extracellular matrix metalloprotease inducer in colorectal adenocarcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.
HTERT mRNA expression correlates with matrix metalloproteinase-1 and vascular endothelial growth factor expression in human breast cancer: a correlative study using RT-PCR.
Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth.
Human keratinocytes express EMMPRIN, an extracellular matrix metalloproteinase inducer.
Human monocyte or recombinant interleukin 1's are specific for the secretion of a metalloproteinase from chondrocytes.
Human prostate tumor angiogenesis in nude mice: metalloprotease and plasminogen activator activities during tumor growth and neovascularization of subcutaneously injected matrigel impregnated with human prostate tumor cells.
Human renal cell carcinoma induces a dendritic cell subset that uses T-cell crosstalk for tumor-permissive milieu alterations.
Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture.
Hypermethylation and Transcriptional Downregulation of the TIMP3 Gene Is Associated with Allelic Loss on 22q12.3 and Malignancy in Meningiomas.
Hypersensitivity pneumonitis: an immunopathology review.
Hypothalamic tumor necrosis factor-alpha converting enzyme mediates excitatory amino acid-dependent neuron-to-glia signaling in the neuroendocrine brain.
Hypotoxic copper complexes with potent anti-metastatic and anti-angiogenic activities against cancer cells.
Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells.
Hypoxia-Inducible Exosomes Facilitate Liver-Tropic Premetastatic Niche in Colorectal Cancer.
Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells.
Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model.
Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment of rheumatoid arthritis.
Identification of a metalloproteinase co-purifying with rat tumour collagenase and the characteristics of fragments of both enzymes.
Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells: (auto-)catalytic activation and resistance to inhibition by TIMP-1.
Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1.
Identification of activated matrix metalloproteinase-2 (MMP-2) as the main gelatinolytic enzyme in malignant melanoma by in situ zymography.
Identification of BARD1 splice-isoforms involved in human trophoblast invasion.
Identification of Biomarkers for Footpad Dermatitis Development and Wound Healing.
Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues.
Identification of methionine aminopeptidase 2 as a molecular target of the organoselenium drug ebselen and its derivatives/analogues: Synthesis, inhibitory activity and molecular modeling study.
Identification of molecular phenotypic descriptors of breast capsular contracture formation using informatics analysis of the whole genome transcriptome.
Identification of potential crucial genes associated with the pathogenesis and prognosis of pancreatic adenocarcinoma.
Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen.
IL-10 inhibits the NF-?B and ERK/MAPK-mediated production of pro-inflammatory mediators by up-regulation of SOCS-3 in Trypanosoma cruzi-infected cardiomyocytes.
IL-18 and IL-12 synergy induces matrix degrading enzymes in the lung.
IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage.
IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-? Through the JAK-STAT Signaling Pathway.
Immunohistochemical analysis of type IV collagenase expression in prostatic hyperplasia and adenocarcinoma.
Immunohistochemical evaluation of type IV collagenase (72-kd metalloproteinase) in prostatic intraepithelial neoplasia.
Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.
Immunohistochemical expression of vascular endothelial growth factor, matrix metalloproteinase 2, and matrix metalloproteinase 9 in cutaneous melanocytic lesions.
Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast.
Immunohistochemical study of tumor necrosis factor-alpha, matrix metalloproteinase-12, and tissue inhibitor of metalloproteinase-2 on alveolar macrophages of BALB/c mice exposed to short-term cigarette smoke.
Immunoreactivity for TIMP-2 is associated with a favorable prognosis in endometrial carcinoma.
Impact of atrial fibrillation on inflammatory and fibrinolytic variables in the elderly.
Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes.
Impact of Parstatin on Experimental Periodontal Disease and Repair in Rats.
Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.
Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis.
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1.
In situ detection of matrix metalloproteinase-2 (MMP2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis.
In situ imaging of aminopeptidase N activity in hepatocellular carcinoma: a migration model for tumour using an activatable two-photon NIR fluorescent probe.
In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin.
In vitro anti-inflammatory properties of Smilax campestris aqueous extract in human macrophages, and characterization of its flavonoid profile.
In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.
In vitro method for diagnosing and monitoring renal cell carcinoma using matrix metalloprotease-7 as humoral biomarker.
In vivo Efficacy of Marimastat and Chemoradiation in Head and Neck Cancer Xenografts.
In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy.
In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification.
In vivo inflammatory response to polymethylmethacrylate particulate debris: effect of size, morphology, and surface area.
In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.
In-silico evidence of ADAM metalloproteinase pathology in cancer signaling networks.
Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals.
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer.
Increased serum 72 KDa metalloproteinase in serous ovarian tumors: comparison with CA 125.
Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat.
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
Increasing EMMPRIN and matriptase expression in hepatocellular carcinoma: tissue microarray analysis of immunohistochemical scores with clinicopathological parameters.
Increasing expression of extracellular matrix metalloprotease inducer in ovary tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Increasing expression of extracellular matrix metalloprotease inducer in renal cell carcinoma: tissue microarray analysis of immunostaining score with clinicopathological parameters.
Induction of fibroblast 92 kDa gelatinase/type IV collagenase expression by direct contact with metastatic tumor cells.
Induction of matrix metalloprotease-7 is common in mucinous ovarian tumors including early stage disease.
Induction of matrix metalloproteinase 9 expression in breast carcinoma cells by a soluble factor from fibroblasts.
Infection with Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Human Cholangiocytes.
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis.
Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer.
Inflammatory Protein Serum Amyloid A1 Marks a Subset of Conventional Renal Cell Carcinomas with Fatal Outcome.
Inflection Point of the Localized Surface Plasmon Resonance Peak: A General Method to Improve the Sensitivity.
Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses.
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Inhibition of ADAMTS1 Expression by Lentiviral CRISPR/Cas9 Gene Editing Technology.
Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma.
Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor.
Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3.
Inhibition of metalloproteinase activity by fruit extracts.
Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin.
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids.
Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer.
Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts.
Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain.
Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4.
Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.
Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs.
Initial steps of metastasis: Cell invasion and endothelial transmigration.
Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease.
Insights and perspectives on calcium channel functions in the cockpit of cancerous space invaders.
Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.
Integrated Metalloproteinase, pH and Glutathione Responsive Prodrug-Based Nanomedicine for Efficient Target Chemotherapy.
Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts.
Interferon-beta treatment of experimental autoimmune encephalomyelitis leads to rapid nonapoptotic termination of T cell infiltration.
Interferon-gamma down-regulates expression of tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats.
Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia.
Interleukin-1 beta induces differential gene expression in aortic smooth muscle cells.
Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1.
Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice.
Interleukin-10 induced activating transcription factor 3 transcriptional suppression of matrix metalloproteinase-2 gene expression in human prostate CPTX-1532 Cells.
Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
Interleukin-1beta secreted from monocytic cells induces the expression of matrilysin in the prostatic cell line LNCaP.
Interleukin-32: Frenemy in cancer?
Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.
Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity.
Intracellular maturation of the mouse metalloprotease disintegrin MDC15.
Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals.
Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.
iRhom2 and TNF: Partners or enemies?
iRhom2: An Emerging Adaptor Regulating Immunity and Disease.
Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.
Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1?
Isolation, characterization, and expression of stromelysin-1 in primary tumors of dogs.
Joint hemorrhage accelerates cartilage degeneration in a rat immobilized knee model.
KDM1A promotes tumor cell invasion by silencing TIMP3 in non-small cell lung cancer cells.
Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core.
KiSS1 gene as a novel mediator of TGF?-mediated cell invasion in triple negative breast cancer.
KISS1 tumor suppressor restricts angiogenesis of breast cancer brain metastases and sensitizes them to oncolytic virotherapy in vitro.
LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
LncRNA PCGEM1 Induces Ovarian Carcinoma Tumorigenesis and Progression Through RhoA Pathway.
Local activity of matrix metalloproteinases in a case of botryoid sarcoma.
Localization of messenger RNA for tissue inhibitor of metalloproteinases-1 and type IV collagenases/gelatinases in monkey hepatocellular carcinomas.
Long-pulsed 1064-nm Nd: YAG laser ameliorates LL-37-induced rosacea-like skin lesions through promoting collagen remodeling in BALB/c mice.
Loss of ADAM9 Leads to Modifications of the Extracellular Matrix Modulating Tumor Growth.
Loss of ectodomain shedding due to mutations in the metalloprotease and cysteine-rich/disintegrin domains of the tumor necrosis factor-alpha converting enzyme (TACE).
Loss of TIMP-3 Promotes Tumor Invasion via Elevated IL-6 Production and Predicts Poor Survival and Relapse in HPV-Infected Non-Small Cell Lung Cancer.
Low levels of ADAM23 expression in epithelial ovarian cancer are associated with poor survival.
Low-Molecular-Weight Fucoidan as Complementary Therapy of Fluoropyrimidine-Based Chemotherapy in Colorectal Cancer.
LRP6 is involved in the proliferation, migration and invasion of trophoblast cells via miR?346.
Lung transplant ischemia reperfusion injury: metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-alpha expression.
Lymph Node Metastasis of Gastric Cancer Is Associated with the Interaction Between Poly (ADP-Ribose) Polymerase 1 and Matrix Metallopeptidase 2.
Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.
Macrocyclisation of small peptides enabled by oxetane incorporation.
Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy.
Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK.
Magnetic resonance imaging detects early changes in microvascular permeability in xenograft tumors after treatment with the matrix metalloprotease inhibitor Prinomastat.
Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP.
Mangiferin inhibits tumor necrosis factor-?-induced matrix metalloproteinase-9 expression and cellular invasion by suppressing nuclear factor-?B activity.
Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.
Mast cell targeting hampers prostate adenocarcinoma development but promotes the occurrence of highly malignant neuroendocrine cancers.
Matrilysin (matrix metalloproteinase-7) expression in ulcerative colitis-related tumorigenesis.
Matrix metalloprotease 1a deficiency suppresses tumor growth and angiogenesis.
Matrix Metalloprotease 2-Responsive Multifunctional Liposomal Nanocarrier for Enhanced Tumor Targeting.
Matrix Metalloprotease Generated Fragments of Type VI Collagen Have Serum Biomarker Potential in Cancer - A Proof of Concept Study.
Matrix metalloprotease selective peptide substrates cleavage within hydrogel matrices for cancer chemotherapy activation.
Matrix metalloprotease triggered delivery of cancer chemotherapeutics from hydrogel matrixes.
Matrix metalloproteinase (MMP)-2 and MMP-9 Expression in Tumor Infiltrating CD3 Lymphocytes From Women With Endometrial Cancer.
Matrix metalloproteinase inhibitors and cancer: trials and tribulations.
Matrix Metalloproteinase Sensitive Gold Nanorod for Simultaneous Bioimaging and Photothermal Therapy of Cancer.
Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas.
Matrix Metalloproteinase-1 Genotype Contributes to the Risk of Non-solid Tumor in Childhood Leukemia.
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
Matrix Metalloproteinase-13 - A Potential Biomarker for Detection and Prognostic Assessment of Patients with Esophageal Squamous Cell Carcinoma.
Matrix metalloproteinase-2 promoter and tissue inhibitor of metalloproteinase-2 gene polymorphisms in non-Hodgkin's lymphoma.
Matrix metalloproteinase-7 expression in gastric carcinoma.
Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study.
Matrix metalloproteinases 2, 3, 13 and their type 2 tissue inhibitor in tumors and plasma of patients with colorectal cancer.
Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms.
Matrix metalloproteinases 7 and 9 and their types 1 and 4 tissue inhibitors in tumors and plasma of patients with colorectal cancer.
Matrix metalloproteinases and TACE play a role in the pathogenesis of endometriosis.
Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic.
Matrix metalloproteinases, angiogenesis, and cancer: commentary re: A. C. Lockhart et al., Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin. Cancer Res., 9: 00-00, 2003.
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.
Mechanisms of cellular invasiveness: a comparison of amnion invasion in vitro and metastatic behavior in vivo.
Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma.
Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors.
Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell lines.
Membrane type-1 matrix metalloproteinase promotes human melanoma invasion and growth.
Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration.
Membrane type-matrix metalloproteinase and tumor invasion.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo.
Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration.
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site.
Metalloproteinase 2 and 9 activity in the development of pancreatic cancer.
Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia.
Metalloproteinase inhibition augments antitumor efficacy of the anti-CD30 immunotoxin Ki-3(scFv)-ETA' against human lymphomas in vivo.
Metalloproteinase inhibitors and the prevention of connective tissue breakdown.
Metalloproteinase meprin ? regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.
Metalloproteinases and the modulation of GH signaling.
Metalloproteinases and their inhibitors in tumor angiogenesis.
Metalloproteinases and transforming growth factor-alpha mediate substance P-induced mitogen-activated protein kinase activation and proliferation in human colonocytes.
Metalloproteinases in tumor progression: the contribution of MMP-9.
Metastasis-associated C4.4A, a GPI-anchored protein cleaved by ADAM10 and ADAM17.
Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance.
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining.
Micronized progesterone pretreatment affects the inflammatory response of human gestational tissues and the cervix to lipopolysaccharide stimulation.
Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients.
MicroRNA-21-5p are involved in apoptosis and invasion of fibroblast-like synoviocytes through PTEN/PI3K/AKT signal.
MicroRNA?122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro.
Minocycline impedes African trypanosome invasion of the brain in a murine model.
Minocycline Inhibits Inflammation and Squamous Metaplasia of Conjunctival Tissue Culture in Airlift Conditions.
Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression.
miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.
MiR-148b functions as a tumor suppressor by targeting endoplasmic reticulum metallo protease 1 in human endometrial cancer cells.
MiR-21 and miR-222 inhibit apoptosis of adult dorsal root ganglion neurons by repressing TIMP3 following sciatic nerve injury.
Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive properties.
MMP-19: cellular localization of a novel metalloproteinase within normal breast tissue and mammary gland tumours.
MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridization.
MMP-2, TIMP-2 and CD44v6 Expression in Non-small-cell Lung Carcinomas.
MMP-2/TIMP-2/TIMP-4 versus MMP-9/TIMP-3 in transition from compensatory hypertrophy and angiogenesis to decompensatory heart failure.
MMP11 expression in intratumoral inflammatory cells in breast cancer.
MMP23B expression and protein levels in blood and urine are associated with bladder cancer.
MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation.
MMP9 mediates MICA shedding in human osteosarcomas.
Modeling invasion patterns in the glioblastoma battlefield.
Modeling of enzyme-substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10.
Modulation of Immune Responses by Platelet-Derived ADAM10.
Modulation of NKG2D-ligand Cell Surface Expression Enhances Immune Cell Therapy of Cancer.
Modulation of peritumoral fibroblasts with a membrane-tethered tissue inhibitor of metalloproteinase (TIMP) for the elimination of cancer cells.
Modulation of redox balance leaves murine diabetogenic TH1 T cells "LAG-3-ing" behind.
Modulation of Sub-RPE deposits in vitro: a potential model for age-related macular degeneration.
Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer.
Modulation of tumor-host interactions, angiogenesis, and tumor growth by tissue inhibitor of metalloproteinase 2 via a novel mechanism.
Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region.
Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment.
Molecular profiling of the tumor microenvironment in glioblastoma patients: correlation of microglia/macrophage polarization state with metalloprotease expression profiles and survival.
Monoclonal antibodies to type IV collagenase recognize a protein with limited sequence homology to interstitial collagenase and stromelysin.
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis.
MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells.
MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway.
MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.
MT4-MMP Modulates the Expression of miRNAs in Breast Cancer Cells.
mTOR Repression in Response to Amino Acid Starvation Promotes ECM Degradation Through MT1-MMP Endocytosis Arrest.
Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells.
Multimodal laser ablation/desorption imaging analysis of Zn and MMP-11 in breast tissues.
Multimodal therapy for synergic inhibition of tumour cell invasion and tumour-induced angiogenesis.
Multiple Acquired Renal Carcinoma Tumor Capabilities Abolished upon Silencing of ADAM17.
Multiple gene methylation of nonsmall cell lung cancers evaluated with 3-dimensional microarray.
Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms.
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Myofibroblasts have an impact on expression, dimerization and signaling of different ErbB receptors in OSCC cells.
N-glycosylation regulates ADAM8 processing and activation.
Nanotherapy Targeting the Tumor Microenvironment.
Natural human monocyte gelatinase and its inhibitor.
Neuropeptides induce Mr 92,000 type IV collagenase (matrix metalloprotease-9) activity in human prostate cancer cell lines.
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Neutrophil elastase processing of gelatinase A is mediated by extracellular matrix.
New alpha-substituted succinate-based hydroxamic acids as TNFalpha convertase inhibitors.
New and emerging pharmacological strategies in the management of chronic heart failure.
New bifunctional metalloproteinase inhibitors: an integrated approach towards biological improvements and cancer therapy.
New insights into germ cell migration and survival/apoptosis in spermatogenesis: Lessons from CD147.
New-onset hypertension and inflammatory response/poor outcome in acute ischemic stroke.
NK cells in therapy of cancer.
No correlation between TIMP2 -418 G>C polymorphism and increased risk of cancer: evidence from a meta-analysis.
Nonsteroidal Anti-Inflammatory Drugs and Prostaglandins: Their Interactions and Effects on the Particulate-Induced Inflammatory Process Implicated in Joint Implant-Loosening and on Monosodium Urate Crystal-Induced Inflammation.
Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia.
Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).
Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer.
Novel role of microRNA-126 in digestive system cancers: From bench to bedside.
Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation.
Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway.
On the move: endocytic trafficking in cell migration.
Opposite Roles of CCR2 and CX3CR1 Macrophages in Alkali-Induced Corneal Neovascularization.
Optimization of a MT1-MMP-targeting Peptide and Its Application in Near-infrared Fluorescence Tumor Imaging.
Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone.
Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma.
Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype.
Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer.
Overexpression of a disintegrin and metalloprotease 8 in human gliomas is implicated in tumor progression and prognosis.
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Overexpression of ADAM9 in oral squamous cell carcinoma.
Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.
Overexpression of stromelysin-3, BM-40/SPARC, and MET genes in human esophageal carcinoma: implications for prognosis.
Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers.
Overview of matrix metalloproteinase expression in cultured human cells.
Oxidative stress and 8-iso-prostaglandin F(2alpha) induce ectodomain shedding of CD163 and release of tumor necrosis factor-alpha from human monocytes.
Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering ?-catenin signalling and GADD45G expression.
Paracrine factor and cell-cell contact-mediated induction of protease and c-ets gene expression in malignant keratinocyte/dermal fibroblast cocultures.
Patterns of in vitro cell-death, metaloproteinase-9 and pro-inflammatory cytokines in human monocytes induced by the BCG vaccine, Moreau strain.
pEGFP-N1-mediated BmK CT expression suppresses the migration of glioma.
Periodontal treatment down-regulates protease-activated receptor-2 in human gingival crevicular fluid cells.
Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells.
Phospholipase C?1 suppresses cell migration and invasion of breast cancer cells by modulating KIF3A-mediated ERK1/2/?- catenin/MMP7 signalling.
Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.
PIN I-III: when should we interfere?
Placental endogenous retrovirus (ERV): structural, functional, and evolutionary significance.
Plasma adrenomedullin and proadrenomedullin N-terminal 20 peptide in patients diagnosed as having early rheumatoid arthritis.
Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1.
Plasma assay of gelatinase B: tissue inhibitor of metalloproteinase complexes in cancer.
Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors.
Plasma levels of MMP-7 and TIMP-1 in laboratory diagnostics and differentiation of selected histological types of epithelial ovarian cancers.
Plasminogen activator and matrix metalloproteinase production and extracellular matrix degradation by rat prostate cancer cells in vitro: correlation with metastatic behavior in vivo.
Plasminogen activator and metalloprotease activities of Du-145, PC-3, and 1-LN-PC-3-1A human prostate tumors grown in nude mice: correlation with tumor invasive behavior.
Plasmodium infection inhibits tumor angiogenesis through effects on tumor-associated macrophages in a murine implanted hepatoma model.
Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response.
Porphyromonas gingivalis stimulates TACE production by T cells.
Possible pathophysiological role of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) in metastatic brain tumor-associated intracerebral hemorrhage.
Post-transcriptional up-regulation of ADAM17 upon epidermal growth factor receptor activation and in breast tumors.
Posttranslational regulation of membrane type 1-matrix metalloproteinase (MT1-MMP) in mouse PTEN null prostate cancer cells: Enhanced surface expression and differential O-glycosylation of MT1-MMP.
Potential applications of tissue inhibitor of metalloproteinase (TIMP) overexpression for cancer gene therapy.
Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Potential of fluorescent metalloproteinase substrates for cancer detection.
Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling.
Predictive value of lymph node and tumor matrix metalloproteinase expression in the analysis of metastatic periampullary tumors.
Pressure and Temperature Effects on the Activity and Structure of the Catalytic Domain of Human MT1-MMP.
Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells.
Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing.
Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats.
Production of active MMP7 in E. coli and its application for metalloproteinase inhibitors screening.
Proenzyme therapy of cancer.
Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice.
Profiling the evolution of human metastatic bladder cancer.
Prognostic impact of extracellular matrix metalloprotease inducer: immunohistochemical analyses of colorectal tumors and immunocytochemical screening of disseminated tumor cells in bone marrow from patients with gastrointestinal cancer.
Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer.
Prognostic significance of MMP-1 and MMP-3 functional promoter polymorphisms in colorectal cancer.
Prognostic stratification of stage IIIA pN2 non-small cell lung cancer by hierarchical clustering analysis of tissue microarray immunostaining data: an Alpe Adria Thoracic Oncology Multidisciplinary Group study (ATOM 014).
Prognostic value of matrix metalloproteinase-2 (MMP-2) expression in endometrial endometrioid adenocarcinoma.
Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer.
Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release.
Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells.
Promoter methylation status of multiple genes in brain metastases of solid tumors.
Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-alpha-converting enzyme and matrix metalloproteinases despite their high structural similarity.
Properties of a plasma membrane-associated cathepsin B-like cysteine proteinase in metastatic B16 melanoma variants.
Protease-activated receptor signalling, endocytic sorting and dysregulation in cancer.
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited.
Proteases and emphysema.
Protective role of transforming growth factor beta (TGF beta) in tumor-induced degradation of basement membranes.
Protein kinase C isotypes required for phorbol-ester induction of stromelysin-1 in rat fibroblasts.
Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease.
Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types.
Proteolysis in colorectal cancer.
Proteolysis is the most fundamental property of malignancy and its inhibition may be used therapeutically (Review).
Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein.
PROX1 is a transcriptional regulator of MMP14.
Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer.
Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma.
Questions about XY Wen et al. entitled "Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis".
Rabs and cancer cell motility.
Ras oncogene mediated induction of a 92 kDa metalloproteinase; strong correlation with the malignant phenotype.
Recent advances in cytogenetics and molecular biology of adult hepatocellular tumors: implications for imaging and management.
Recent advances in the development of MMPIs and APNIs based on the pyrrolidine platforms.
Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells.
Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site.
Recurrence patterns in locally advanced cervical carcinoma: role of nodal status and 72-kDa metalloproteinase index.
Reduced CD62L Expression on T Cells and Increased Soluble CD62L Levels Predict Molecular Response to Tyrosine Kinase Inhibitor Therapy in Early Chronic-Phase Chronic Myelogenous Leukemia.
Regulated delivery of molecular cargo to invasive tumour-derived microvesicles.
Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?
Regulation of matrix metalloproteinase (MMP) activity by the low-density lipoprotein receptor-related protein (LRP). A new function for an "old friend".
Regulation of membrane metalloproteolytic cleavage of L-selectin (CD62l) by the epidermal growth factor domain.
Regulation of MT1-MMP Activity through Its Association with ERMs.
Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling.
Regulation of the ?-secretase ADAM10 at transcriptional, translational and post-translational levels.
Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy.
Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts.
Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor.
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma.
Relationship between metalloprotease expression in tumour and stromal cells and aggressive behaviour in prostate carcinoma: Simultaneous high-throughput study of multiple metalloproteases and their inhibitors using tissue array analysis of radical prostatectomy samples.
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.
Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, Crotalus atrox.
Resveratrol-mediated ADAM9 degradation decreases cancer progression and provides synergistic effects in combination with chemotherapy.
Retinoic acid and vitamin E modulate expression and release of CD178 in carcinoma cells: consequences for induction of apoptosis in CD95-sensitive cells.
Retinoic acids reduce matrilysin (matrix metalloproteinase 7) and inhibit tumor cell invasion in human colon cancer.
Reverse transcription-polymerase chain reaction phenotyping of metalloproteinases and inhibitors involved in tumor matrix invasion.
RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease.
Role of matrix metalloproteinase-9 in progression of mouse skin carcinogenesis.
Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors.
Role of PKC-? in NF-?B-MT1-MMP-mediated activation of proMMP-2 by TNF-? in pulmonary artery smooth muscle cells.
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Role of tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and associated proteins in coronary artery disease and cardiac events.
Rosiglitazone inhibits metastasis development of a murine mammary tumor cell line LMM3.
Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3? axis.
S-nitroso-N-acetylcysteine attenuates liver fibrosis in cirrhotic rats.
Scutellarin Attenuates the IL-1?-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression.
Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface.
Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine kinase pathway in mammary tumor cells.
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer.
Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation.
Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer.
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis.
Selective MMP-12 inhibitors: WO-2008057254.
Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.
Separation and identification methods for metalloproteinase inhibitors.
Serum matrix metalloproteinase 7 levels identifies poor prognosis advanced colorectal cancer patients.
Serum Monocyte Chemotactic Protein-1 Concentrations Distinguish Patients With Ankylosing Spondylitis From Patients With Mechanical Low Back Pain.
Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection.
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Sharks: a potential source of antiangiogenic factors and tumor treatments.
Shedding light on sheddases: role in growth and development.
Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment.
Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2.
Signal transducers and activators of transcription-3 up-regulates tissue inhibitor of metalloproteinase-1 expression and decreases invasiveness of breast cancer.
Significance of matrix metalloproteinases and tissue inhibitors of metalloproteinase expression in the recurrence of superficial transitional cell carcinoma of the bladder.
Significance of microRNA 21 in gastric cancer.
Skin Immunomodulation during Regeneration: Emerging New Targets.
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.
Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma.
Sodium Intake Is associated With Endothelial Damage Biomarkers and Metabolic Dysregulation.
Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?
Soluble epoxide hydrolase disruption as therapeutic target for wound healing.
Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).
Spironolactone prevents alterations associated with cardiac hypertrophy produced by isoproterenol in rats: involvement of SGK-1.
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis.
SRC fine-tunes ADAM10 shedding activity to promote pituitary adenoma cell progression.
Stimulation of the 92-kD type IV collagenase promoter and enzyme expression in human melanoma cells.
Stimulation of TIMP-1 and metalloproteinase production in co-cultures of human tumor cells and human fibroblasts.
Stromal expression of 72 kda type IV collagenase (MMP-2) and TIMP-2 mRNAs in colorectal neoplasia.
Stromelysin in tumor progression and metastasis.
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines.
Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo.
Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front.
Stromelysin-3 is expressed by aggressive meningiomas.
Structure, regulatory factors and cancer-related physiological effects of ADAM9.
Subcurative radiation significantly increases proliferation, invasion, and migration of primary GBM in vivo.
Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity.
Suppression of gastric cancer dissemination by ephrin-B1-derived peptide.
Suppression of liver tumor growth and metastasis by adiponectin in nude mice through inhibition of tumor angiogenesis and downregulation of Rho kinase/IFN-inducible protein 10/matrix metalloproteinase 9 signaling.
Suppression of metalloproteinase biosynthesis in human alveolar macrophages by interleukin-4.
Surgical excision promotes tumor growth and metastasis by promoting expression of MMP-9 and VEGF in a breast cancer model.
Surgical treatment and prognostic factors in giant-cell tumor of bone.
Survival impact of psammoma body, stromal calcification, and bone formation in papillary thyroid carcinoma.
Survival prediction based on the gene expression associated with cancer morphology and microenvironment in primary central nervous system lymphoma.
Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion.
Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis.
Synthetic inhibitor of matrix metalloproteases decreases tumor growth and metastases in a syngeneic model of rat prostate cancer in vivo.
Synthetic inhibitor of matrix metalloproteinases (batimastat) reduces prostate cancer growth in an orthotopic rat model.
Synthetic matrix metalloproteinase inhibitor, BB-94, inhibits the invasion of neoplastic human prostate cells in a mouse model.
Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor-alpha receptors in a human colon adenocarcinoma (Colo 205) cell line.
Systemic inflammation in chronic obstructive pulmonary disease and asthma: Similarities and differences.
Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.
TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.
TACE and other ADAM proteases as targets for drug discovery.
TACE is required for fetal murine cardiac development and modeling.
TACE-dependent EGF receptor activation in angiotensin-II-induced kidney disease.
TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation.
Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer.
Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-alpha converting enzyme.
Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand.
Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface.
Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis.
Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines.
Targeting matrilysin and its impact on tumor growth in vivo: the potential implications in breast cancer therapy.
Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy.
Targeting the Urotensin II/UT G Protein-Coupled Receptor to Counteract Angiogenesis and Mesenchymal Hypoxia/Necrosis in Glioblastoma.
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.
Teneligliptin inhibits IL-1?-induced degradation of extracellular matrix in human chondrocytes.
Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis.
TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.
The 72-kDa metalloproteinase immunostaining in cervical carcinoma: relationship with lymph nodal involvement.
The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.
The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway.
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
The antiangiogenic agent neovastat (AE-941) inhibits vascular endothelial growth factor-mediated biological effects.
The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency.
The blood-brain and gut-vascular barriers: from the perspective of claudins.
The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.
The carboxyl terminal trimer of procollagen I induces pro-metastatic changes and vascularization in breast cancer cells xenografts.
The cell-specific expression of metalloproteinase-disintegrins (ADAMs) in inflammatory myopathies.
The correlation between the expression of ADAM17, EGFR and Ki-67 in malignant gliomas.
The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition.
The disintegrin and metalloprotease Meltrin from Drosophila forms oligomers via its protein binding domain and is regulated by the homeobox protein VND during embryonic development.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia.
The Effect of Chrysin Loaded PLGA-PEG on Metalloproteinase Gene Expression in Mouse 4T1 Tumor Model.
The effect of recombinant tumor necrosis factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes.
The efficacy and mechanism action of RvCSd, a new herbal agent, on immune suppression and cartilage protection in a mouse model of rheumatoid arthritis.
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone.
The Expression, Function and Targeting of Haem Oxygenase-1 in Cancer.
The favorable prognostic impact of tissue inhibitor of matrix metalloproteinases-1 protein overexpression in breast cancer cells.
The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13.
The Importance of the Knee Joint Meniscal Fibrocartilages as Stabilizing Weight Bearing Structures Providing Global Protection to Human Knee-Joint Tissues.
The invasiveness of five medulloblastoma cell lines in collagen gels.
The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis - A mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide.
The K.G. McKenzie award lecture--1986. Effects of extracellular matrix proteins on the growth and differentiation of an anaplastic glioma cell line.
The matrix metalloprotease pump-1 (MMP-7, Matrilysin): A candidate marker/target for ovarian cancer detection and treatment.
The matrix metalloproteinase inhibitor marimastat inhibits seizures in a model of kainic acid-induced status epilepticus.
The matrix metalloproteinase/tissue inhibitor of matrix metalloproteinase profile in colorectal polyp cancers.
The metalloprotease ADAM17 in inflammation and cancer.
The metalloprotease ADAMTS8 displays antitumor properties through antagonizing EGFR-MEK-ERK signaling and is silenced in carcinomas by CpG methylation.
The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors.
The phosphorylation of CD147 by Fyn plays a critical role for melanoma cells growth and metastasis.
The Potential Role of Medicinal Plants in Bone Regeneration.
The Precise Diagnosis of Cancer Invasion/Metastasis via 2D Laser Ablation Mass Mapping of Metalloproteinase in Primary Cancer Tissue.
The relevance of piroxicam for the prevention and treatment of nonmelanoma skin cancer and its precursors.
The role of ADAMTS-13 and von Willebrand factor in cancer patients: Results from the Vienna Cancer and Thrombosis Study.
The role of angiogenesis in the accumulation of peritoneal fluid in benign conditions and the development of malignant ascites in the female.
The role of cytokines in chondrocyte mediated cartilage degradation.
The role of human papillomavirus DNAs in cervical carcinoma and risk of lymph node metastasis: association with 72-kilodalton metalloproteinase immunostaining.
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease.
The role of the carbohydrates in plasmatic membrane.
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression.
The SOD mimic MnTM-2-PyP(5+) reduces hyaluronan degradation-induced inflammation in mouse articular chondrocytes stimulated with Fe (II) plus ascorbate.
The Stromal Overexpression of CD10 in Invasive Breast Cancer and its Association with Clincophathologic Factors.
The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.
The therapeutic potential of ADAM15.
The tissue-renin-angiotensin-system of the human intervertebral disc.
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.
The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells.
Therapeutic Hypothermia Reduces the Inflammatory Response Following Ischemia/Reperfusion Injury in Rat Hearts.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Three Tiaobu Feishen formulae reduces cigarette smoke-induced inflammation in human airway epithelial cells.
Three-dimensional culture using a radial flow bioreactor induces matrix metalloprotease 7-mediated EMT-like process in tumor cells via TGFbeta1/Smad pathway.
Thrombin conducts epithelial?mesenchymal transition via protease?activated receptor?1 in human gastric cancer.
TIMP1 and adverse prognosis in non-small cell lung cancer.
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis.
Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer.
TIMP4 Modulates ER-? Signalling in MCF7 Breast Cancer Cells.
Tissue inhibitor metalloproteinase type-1 (TIMP-1), a novel cancer biomarker predicting response of adjuvant anthracycline-based chemotherapy in patients afflicted with primary breast cancer.
Tissue inhibitor of matrix metalloproteinase-2 regulates matrix metalloproteinase-2 activation by modulation of membrane-type 1 matrix metalloproteinase activity in high and low invasive melanoma cell lines.
Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.
Tissue inhibitor of metalloproteinase-1 stimulates proliferation of human cancer cells by inhibiting a metalloproteinase.
Tissue structure, and IL-1beta, IL-8, and TNF-alpha secretions after contact by engineered human oral mucosa with dentifrices.
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
TLR4-mediated immunomodulatory properties of the bacterial metalloprotease arazyme in preclinical tumor models.
TNF-? blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.
Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin.
TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion.
Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme.
Toxicodendron vernicifluum Stokes extract inhibits solid tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in BALB/c mice.
TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1.
Tracking cell invasion of human glioma cells and suppression by anti-matrix metalloproteinase agent in rodent brain-slice model.
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Transforming growth factor alpha (TGF-alpha) and other targets of tumor necrosis factor-alpha converting enzyme (TACE) in murine polycystic kidney disease.
Transforming growth factor beta 1 regulation of metalloproteinase production in cultured human cervical epithelial cells.
Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Transient collagen triple helix binding to a key metalloproteinase in invasion and development.
Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility.
Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinases-2 into the liver tissue.
Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice.
Triptonide inhibits the pathological functions of gastric cancer-associated fibroblasts.
TrkB/C-induced HOXC6 activation enhances the ADAM8-mediated metastasis of chemoresistant colon cancer cells.
Tube travel: the role of proteases in individual and collective cancer cell invasion.
Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat.
Tumor cell cross talk with tumor-associated leukocytes leads to induction of tumor exosomal fibronectin and promotes tumor progression.
Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form.
Tumor M2-Pyruvate Kinase, Matrix Carbonic Anhydrase IX, and Metalloproteinase 9 - Novel Prognostic Markers of Renal Cell Carcinoma.
Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function.
Tumor necrosis factor ?-mediated restructuring of the Sertoli cell barrier in vitro involves matrix metalloprotease 9 (MMP9), membrane-bound intercellular adhesion molecule-1 (ICAM-1) and the actin cytoskeleton.
Tumor necrosis factor alpha (TNFalpha) induces pro-matrix metalloproteinase 9 production in human uterine cervical fibroblasts but interleukin 1alpha antagonizes the inductive effect of TNFalpha.
Tumor necrosis factor alpha and lymphotoxin stimulate human myeloblastic leukemia cell (ML-1) invasion through a reconstituted basement membrane (Matrigel) with concomitant induction of 92 kDa gelatinase secretion.
Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells.
Tumor Necrosis Factor Receptor Superfamily Member 21: TNFR-Related Death Receptor-6, DR6.
Tumor necrosis factor-? alters integrins and metalloprotease ADAM12 levels and signaling in differentiating myoblasts.
Tumor Necrosis Factor-? Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation.
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage.
Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
Tumor necrosis factor-alpha converting enzyme: Implications for ocular inflammatory diseases.
Tumor necrosis factor-alpha-converting enzyme (TACE) levels in periodontal diseases.
Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM-17) mediates the ectodomain cleavage of intercellular adhesion molecule-1 (ICAM-1).
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.
Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase.
Tumor-promoting effect of IL-23 in mammary cancer mediated by infiltration of M2 macrophages and neutrophils in tumor microenvironment.
Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis.
Tumoral CD10 Expression Correlates with Aggressive Histology and Prognosis in Patients with Malignant Pleural Mesothelioma.
Tumour necrosis factor-alpha stimulates expression of TNF-alpha converting enzyme in endothelial cells.
Two transcription factors, E1AF and N-myc, correlate with the invasiveness of neuroblastoma cell lines.
U94 alters FN1 and ANGPTL4 gene expression and inhibits tumorigenesis of prostate cancer cell line PC3.
Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.
Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands.
Up-regulation of the MicroRNA miR-30c Induced by High Mobility Group Box 1 in A549 Cells Used as an Alveolar Epithelial Model.
Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices.
Up-regulation of TRAIL mRNA expression in peripheral blood mononuclear cells from patients with minimal-change nephrotic syndrome.
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Upregulated expression of angiogenesis genes and down regulation of cell cycle genes in human colorectal cancer tissue determined by cDNA macroarray.
Upregulated miR-106a plays an oncogenic role in pancreatic cancer.
Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma.
Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer.
Upregulation of ADAM-17 expression in active lesions in multiple sclerosis.
Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
Upregulation of ADAM19 in chronic allograft nephropathy.
Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion.
Usefulness of VEGF, MMP-2, MMP-3 and TIMP-2 serum level evaluation in patients with adrenal tumours.
Using urinary bFGF and TIMP3 levels to predict the presence of juvenile pilocytic astrocytoma and establish a distinct biomarker signature.
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.
Vascular endothelial growth factor expression in the basal subtype of breast carcinoma.
Vascular-homing peptides for cancer therapy.
Vesicular trafficking regulators are new players in breast cancer progression: Role of TOM1L1 in ERBB2-dependent invasion.
von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans.
ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element.
Zoledronic-acid-induced circulating level modifications of angiogenic factors, metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients.
[Activity of inflammatory-destructive changes in the process of formation of unstable atherosclerotic plaque]
[Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance]
[Diagnosis and treatment of tumor metastases]
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group]
[Effects of TIMP-2 gene transfection on biological behaviors of a metastatic human lung carcinoma cell line]
[Endometriosis: physiopathology and investigation trends (first part)]
[Expression and activity of proteases in metastasis of ovarian cancer].
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
[Expression and pathological mechanism of MMP-9 and HIF-2? in CD133(+) lung cancer stem cells].
[Expression of macrophage inflammatory protein-1alpha, a disintegrin-like and metalloproteinase 8 and 12, and CD68 protein in giant cell lesions of jaw and giant cell tumors of long bone]
[Giant-cell tumor of the bone]
[Immunohistochemical findings in prolonged cerebral hypoxia]
[Inflammatory-destructive biomarkers of atherosclerotic plaques instability. Study of arterial wall and blood].
[Localization and expression of matrix metalloproteinase-7 in human prostate]
[New prognostic factors in human gastric carcinomas]
[Relationship between the expression levels of PAPP-A metalloproteinase and growth and transcriptional factors in endometrial cancer].
[Relationship between the expression of matrix metalloproteinase-13 protein and other biomarkers, prognosis in invasive breast cancer]
[Research on mechanism of tougu xiaotong granule in preventing and treating knee osteoarthritis]
[Roles of matrix metalloproteinases and tissue inhibitor of metalloproteinase (TIMP) in cancer invasion and metastasis]
[Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer]
[Standard treatment of multiple myeloma]
[Study of matrix metalloproteinase-2 and -9 in thyroid papillary cancer]
[Systemic inflammation in COPD and asthma: similarities and differences]
[The suppressing effect of TIMP-3 gene transfection on the invasion and metastasis of human lung carcinoma cells line]
[Therapy for non-small cell lung cancer: new concepts based on molecular biology]
Nephritis
Effect of a specific endothelin A receptor antagonist on murine lupus nephritis.
Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis.
Nephrosis
Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy.
Nephrotic Syndrome
Increased mRNA expression of metalloproteinase-9 in peripheral blood monocytes from patients with immunoglobulin A nephropathy.
Nervous System Diseases
Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli.
[The role of metalloprotease in pathogenesis of nervous system diseases]
Neuralgia
A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy.
Drug Therapy of Neuropathic Pain: Current Developments and Future Perspectives.
Matrix metalloprotease regulation of neuropathic pain.
Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.
Therapeutic potential of matrix metalloprotease inhibitors in neuropathic pain.
Neuroacanthocytosis
The Kell and XK proteins of the Kell blood group are not co-expressed in the central nervous system.
Neuroblastoma
A comparative study of the effects of genistein and 2-methoxyestradiol on the proteolytic balance and tumour cell proliferation.
ADAM15 Participates in Tick-Borne Encephalitis Virus Replication.
Association between favorable neuroblastoma and high expression of the novel metalloproteinase gene, nbla3145/XCE, cloned by differential screening of the full-length-enriched oligo-capping neuroblastoma cDNA libraries.
Carnosic acid suppresses the production of amyloid-? 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells.
Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis.
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate.
Phenanthroline impairs ?APP processing and expression, increases p53 protein levels and induces cell cycle arrest in human neuroblastoma cells.
Platelet activating factor inhibits the expression of matrix metalloproteinases and affects invasiveness and differentiation in a system of human neuroblastoma clones.
Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site.
Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines.
Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin ?1; ADAP1) in neuroblastoma cells.
Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation.
Tandem duplication. A novel type of triplet repeat instability.
TBJ murine neuroblastoma resists dibutyryl cyclic AMP-induced differentiation and effects on metalloproteinase secretion.
Thioredoxin alters the matrix metalloproteinase/tissue inhibitors of metalloproteinase balance and stimulates human SK-N-SH neuroblastoma cell invasion.
Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-?1 (ADAP1).
Two new human neuroblastoma cell lines exhibiting tumorigenesis and metastasis in the nude mouse model.
Neurodegenerative Diseases
An integrated in silico approach to understand protein-protein interactions: human meprin-? with fetuin-A.
Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Pharmacophore modeling coupled with molecular dynamic simulation approach to identify new leads for meprin-? metalloprotease.
Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration.
Neuroectodermal Tumors
Regulation by retinoic acid of insulin-degrading enzyme and of a related endoprotease in human neuroblastoma cell lines.
Neuroendocrine Tumors
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Neuroinflammatory Diseases
Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.
Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases.
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Metalloproteinases control brain inflammation induced by pertussis toxin in mice overexpressing the chemokine CCL2 in the central nervous system.
MMPs and ADAMs in neurological infectious diseases and multiple sclerosis.
Selected CSF biomarkers indicate no evidence of early neuroinflammation in Huntington disease.
Neurologic Manifestations
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
Neuroma, Acoustic
Analysis of ADAM9 regulation and function in vestibular schwannoma primary cells.
Nevus
The 'Abtropfung phenomenon' revisited: Dermal nevus cells from congenital nevi cannot activate matrix metalloproteinase 2 (MMP-2).
Non-alcoholic Fatty Liver Disease
Association of tissue inhibitor of metalloproteinase 2 with non-alcoholic fatty liver disease in metabolic syndrome.
Fibrogenesis and Carcinogenesis in Nonalcoholic Steatohepatitis (NASH): Involvement of Matrix Metalloproteinases (MMPs) and Tissue Inhibitors of Metalloproteinase (TIMPs).
Serum levels of hyaluronic acid and tissue metalloproteinase inhibitor-1 combined with age predict the presence of nonalcoholic steatohepatitis in a pilot cohort of subjects with nonalcoholic fatty liver disease.
The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease.
Obesity
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Effects of Korean red ginseng (Panax ginseng) on obesity and adipose inflammation in ovariectomized mice.
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Hydrogen Sulfide Depletion Contributes to Microvascular Remodeling in Obesity.
In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice.
Interleukin 29 activates expression of tissue inhibitor of metalloproteinase 1 in macrophages via toll?like receptor 2.
Lipid Peroxidation, Protein Oxidation, Gelatinases, and Their Inhibitors in a Group of Adults with Obesity.
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.
Polymorphisms of matrix metalloproteinase gene and adiposity indices in European children: results of the IDEFICS study.
Proinflammatory adipocytokines induce TIMP-1 expression in 3T3-L1 adipocytes.
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
Tissue inhibitor of metalloproteinase 1 expression and secretion are induced by beta-adrenergic stimulation in 3T3-L1 adipocytes.
[Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis].
Obstetric Labor, Premature
Effect of the putative novel selective ETA-receptor antagonist HJP272, a 1,3,6-trisubstituted-2-carboxy-quinol-4-one, on infection-mediated premature delivery.
Ocular Hypertension
Bimatoprost, latanoprost, and tafluprost induce differential expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases.
Odontogenic Cysts
Collagenase-3 expression in periapical lesions: an immunohistochemical study.
HIF-1? is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1? and NOTCH1 Signaling Pathways.
Onycholysis
[The blood biochemical indicators as possible markers of destruction of kerato-hyaline tissue of nails in patients with onycholysis].
Opportunistic Infections
Interactions between HIV-infected monocytes and the extracellular matrix: HIV-infected monocytes secrete neutral metalloproteases that degrade basement membrane protein matrices.
Optic Atrophy, Autosomal Dominant
Chronic Exercise Improves Mitochondrial Function and Insulin Sensitivity in Brown Adipose Tissue.
Optic Nerve Diseases
Metalloproteinase 9 and TIMP-1 expression in retina and optic nerve in absolute angle closure glaucoma.
Optic Nerve Glioma
Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma.
Optic Neuritis
Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases.
Osteoarthritis
10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin.
Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.
ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity.
Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis.
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.
Anti-osteoarthritic Effects of an Herbal Composition LI73014F2 on Interleukin-1?-induced Primary Human Articular Chondrocytes.
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2).
Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis.
Basic calcium phosphate crystals induce synthesis and secretion of 92 kDa gelatinase (gelatinase B/matrix metalloprotease 9) in human fibroblasts.
Biologic basis of osteoarthritis: state of the evidence.
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Changes in immunolocalisation of beta-dystroglycan and specific degradative enzymes in the osteoarthritic synovium.
Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implications.
Correction to: Relationship Between Magnetic Resonance T2-Mapping and Matrix Metalloproteinase 1,3 in Knee Osteoarthritis.
Cytokine inducible matrix metalloproteinase expression in immortalized rat chondrocytes is independent of nitric oxide stimulation.
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
Design strategies for the identification of MMP-13 and Tace inhibitors.
Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Diagnostic utility of fluorogenic peptide-conjugated Au nanoparticle probe corroborated by rabbit model of mild cartilage injury and panel of osteoarthritic patients.
Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats.
Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT).
Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).
Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase.
Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice.
Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro.
Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis.
Effects of different molecular weight hyaluronan products on the expression of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis.
Effects of tenidap on canine experimental osteoarthritis. I. Morphologic and metalloprotease analysis.
Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-?B and Wnt/?-catenin signaling in-vitro and in-vivo.
Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM-Increased serum CIIM in subjects with severe radiographic osteoarthritis.
Evaluating the Effects of Platelet-Rich Plasma and Amniotic Viscous Fluid on Inflammatory Markers in a Human Coculture Model for Osteoarthritis.
Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to cartilage degradation in osteoarthritis and rheumatoid arthritis.
Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage.
Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome.
Guava leaf extract suppresses osteoarthritis progression in a rat anterior cruciate ligament transection model.
Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage.
Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.
Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling.
Hyaluronan derivative HYMOVIS® increases cartilage volume and type ii collagen turnover in osteoarhritic knee: data from MOKHA study.
Immunological detection of type II collagen degradation: use in the evaluation of anti-arthritic therapies.
Implication of MMP-9 and urokinase plasminogen activator (uPA) in the activation of pro-matrix metalloproteinase (MMP)-13.
Increased expression of pro-inflammatory cytokines and metalloproteinase-1 by TGF-beta1 in synovial fibroblasts from rheumatoid arthritis and normal individuals.
Interaction of HIF1? and ?-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice.
Interleukin 13 (IL-13)-regulated expression of the chondroprotective metalloproteinase ADAM15 is reduced in aging cartilage.
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3.
Intra-articular administration of xenogeneic neonatal Mesenchymal Stromal Cells early after meniscal injury down-regulates metalloproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis.
Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2.
Intra-articular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis.
Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis.
Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes.
Levels of metalloproteases and tissue inhibitor of metalloproteases in human osteoarthritic cartilage.
Levels of metalloproteinase (MMP-3, MMP-9), NF-kappaB ligand (RANKL), and nitric oxide (NO) in peripheral blood of osteoarthritis (OA) patients.
Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes.
Low-density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4: Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.
Metalloprotease activity, phospholipase A2 activity and cytokine concentration in osteoarthritis synovial fluids.
Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis.
Metalloproteinase inhibitors: new opportunities for the treatment of rheumatoid arthritis and osteoarthritis.
MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes.
Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
Molecular targets in osteoarthritis: metalloproteinases and their inhibitors.
Naproxen, meloxicam and methylprednisolone inhibit urokinase plasminogen activator and inhibitor and gelatinases expression during the early stage of osteoarthritis.
Nesfatin-1 suppresses interleukin-1?-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats.
Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.
Notch signaling is involved in human articular chondrocytes de-differentiation during osteoarthritis.
Osteoblasts Regulate the Expression of ADAMTS and MMPs in Chondrocytes through ERK Signaling Pathway.
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding.
Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.
Phosphorylation of osteopontin in osteoarthritis degenerative cartilage and its effect on matrix metalloprotease 13.
Potent inhibitors precise to S1' loop of MMP-13, a crucial target for osteoarthritis.
Prostromelysin and procollagenase genes are differentially up-regulated in chondrocytes from the knees of rabbits with experimental osteoarthritis.
Purification and Activity Determination of ADAMTS-4 and ADAMTS-5 and Their Domain Deleted Mutants.
Pyrroloquinoline Quinone Slows Down the Progression of Osteoarthritis by Inhibiting Nitric Oxide Production and Metalloproteinase Synthesis.
Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats.
Regulation of metalloproteinase gene expression: implications for osteoarthritis.
Salicin inhibits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis.
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
Selective MMP-12 inhibitors: WO-2008057254.
SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis.
Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4.
Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2).
Targeting Dysregulation of Metalloproteinase Activity in Osteoarthritis.
The alteration of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in the knee joints of osteoarthritis mice.
The design and synthesis of aryl hydroxamic acid inhibitors of MMPs and TACE.
The effect of recombinant tumor necrosis factor-alpha on superoxide and metalloproteinase production by synovial cells and chondrocytes.
The IL-1?/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis.
The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.
The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis.
The therapeutic effects of tenidap in canine experimental osteoarthritis: relationship with biochemical markers.
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
Tumor necrosis factor-alpha (TNF-alpha) in canine osteoarthritis: Immunolocalization of TNF-alpha, stromelysin and TNF receptors in canine osteoarthritic cartilage.
Variable effects of 3 different chondroitin sulfate compounds on human osteoarthritic cartilage/chondrocytes: relevance of purity and production process.
VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts.
WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology.
[Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].
Osteoarthritis, Knee
Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans.
Expression changes of gelatinases in human osteoarthritic knees and arthroscopic debridement.
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients.
Relationship between ADAMTS14/rs4747096 gene polymorphism and knee osteoarthritis in Chinese population.
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis
Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis.
Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritis.
[Mechanism of thermosensitive moxibustion on knee osteoarthritis in rabbit models].
[Repair effects of close-to-bone needing combined with electroacupuncture on extracellular matrix of cartilage in rabbits with knee osteoarthritis].
Osteolysis
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in loose artificial hip joints.
Microenvironmental stimuli affect Endothelin-1 signaling responsible for invasiveness and osteomimicry of bone metastasis from breast cancer.
Osteomalacia
FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.
Osteomyelitis
Staphylococcus aureus osteomyelitis: bad to the bone.
Osteonecrosis
Expression profile of matrix metalloproteinase-2 and -9 and their endogenous tissue inhibitors in osteonecrotic femoral heads.
Osteopetrosis
Multi-trait GWAS using imputed high-density genotypes from whole-genome sequencing identifies genes associated with body traits in Nile tilapia.
Osteophyte
An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention.
Osteosarcoma
ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing.
Cas9 Protein Triggers Differential Expression of Inherent Genes Especially NGFR Expression in 293T Cells.
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Elevated expression of microRNA-328-3p suppresses aggressive malignant behaviors via targeting matrix metalloprotease 16 in osteosarcoma.
Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis.
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in human osteoblast-like cells: differentiation is associated with repression of metalloproteinase biosynthesis.
Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor.
Gene expression changes in BALB/3T3 transformants induced by poly(L-lactic acid) or polyurethane films.
IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.
Inhibition of spontaneous rat osteosarcoma lung metastasis by 3S-[4-(N-hydroxyamino)-2R-isobutylsuccinyl]amino-1-methoxy-3,4-dihydroc arbostyril, a novel matrix metalloproteinase inhibitor.
Letter regarding Wen X.Y. et al. entitled "Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis"
Osteosarcoma oncogene expression detected by in situ hybridization.
Overexpression of matrix metalloproteinase (MMP)-9 correlates with metastatic potency of spontaneous and 4-hydroxyaminoquinoline 1-oxide (4-HAQO)-induced transplantable osteosarcomas in rats.
Questions about XY Wen et al. entitled "Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis".
Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in co-culture of human osteosarcoma cells and human fibroblasts: gelatinase B production was stimulated via up-regulation of fibroblast growth factor (FGF) receptor.
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180.
The anti-neoplastic effect of doxycycline in osteosarcoma as a metalloproteinase (MMP) inhibitor: a systematic review.
Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma.
Otitis Media
Alpha 1-antitrypsin and ilomastat inhibit inflammatory proteases present in human middle ear effusions.
Protease inhibitors alpha1-antitrypsin and ilomastat are not ototoxic in the chinchilla.
Out-of-Hospital Cardiac Arrest
Decreased a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 activity and neurologic outcome in patients with successful resuscitation of out-of-hospital cardiac arrest: A prospective observational study.
Ovarian Neoplasms
Aberrant expression of ADAM9 in ovarian cancer and its clinical significance.
Assessment of prognostic value of tissue inhibitors of metalloproteinase 3 (TIMP3) protein in ovarian cancer.
CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion.
Combinatorial peptide libraries facilitate development of multiple reaction monitoring assays for low-abundance proteins.
Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients.
Exenatide modulates tumor-endothelial cell interactions in human ovarian cancer cells.
Expression of various matrix proteases and Ets family transcriptional factors in ovarian cancer cell lines: correlation to invasive potential.
Functional interplay between type I collagen and cell surface matrix metalloproteinase activity.
Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.
Lysophosphatidic acid enhances epithelial ovarian carcinoma invasion through the increased expression of interleukin-8.
Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer.
M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop.
Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms.
Molecular Targeting of Notch Signaling Pathway by DAPT in Human Ovarian Cancer: Possible Anti Metastatic Effects
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Overexpression of alpha(v)beta6 integrin in serous epithelial ovarian cancer regulates extracellular matrix degradation via the plasminogen activation cascade.
Regulation of monocyte MMP-9 production by TNF-alpha and a tumour-derived soluble factor (MMPSF).
Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis and tumor growth in ovarian cancer.
The matrix metalloprotease pump-1 (MMP-7, Matrilysin): A candidate marker/target for ovarian cancer detection and treatment.
The metalloproteinase inhibitor batimastat (BB-94) causes cell cycle phase perturbations in ovarian cancer cells.
The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer.
Thiophenol-formaldehyde triazole causes apoptosis induction in ovary cancer cells and prevents tumor growth formation in mice model.
Type-IV collagenase and tissue inhibitor of metalloproteinase in ovarian cancer tissues.
[New aspects by the therapy of ovarian cancer--What changes after the ASCO-Meeting 2001]
Overweight
Level of Adiponectin, Leptin and Selected Matrix Metalloproteinases in Female Overweight Patients with Primary Gonarthrosis.
Pancreatic Neoplasms
ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-?B Pathway.
Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression.
CD44 regulates pancreatic cancer invasion through MT1-MMP.
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Gamma-Irradiation Enhances RECK Protein Levels in Panc-1 Pancreatic Cancer Cells.
Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.
Interaction between cancer cells and stromal fibroblasts is required for activation of the uPAR-uPA-MMP-2 cascade in pancreatic cancer metastasis.
L1CAM induces perineural invasion of pancreas cancer cells by upregulation of metalloproteinase expression.
Large-scale clinical validation of biomarkers for pancreatic cancer using a mass spectrometry-based proteomics approach.
M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway.
Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?
Matrix metalloproteinase inhibition suppresses MMP-2 activity and activation of PANC-1 cells in vitro.
Metalloproteinase 2 and 9 activity in the development of pancreatic cancer.
MiR-126 acts as a tumor suppressor in pancreatic cancer cells via the regulation of ADAM9.
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
NS?398 promotes pancreatic cancer cell invasion by CD147 and MMP?2 via the activation of P38.
Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.
Suppression of pancreatic cancer cell invasion by a cyclooxygenase-2-specific inhibitor.
TIMP-1 antisense gene transfection attenuates the invasive potential of pancreatic cancer cells in vitro and inhibits tumor growth in vivo.
Pancreatitis
Hypertonic Saline Reduces Metalloproteinase Expression In Liver During Pancreatitis.
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
Increased gelatinase B/matrix metalloproteinase 9 (MMP-9) activity in a murine model of acute coxsackievirus B4-induced pancreatitis.
The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis.
[The matrix metalloproteinase 9 (MMP-9) and TIMP-1 activities in patients with chronic and recurrent pancreatitis].
Pancreatitis, Chronic
Expression of collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of the metalloproteinases (TIMP1) in pancreatic and ampullary disease.
Prolyl hydroxylase and tissue inhibitor of metalloproteinase in pure pancreatic juice in patients with chronic pancreatitis.
Papillomavirus Infections
Microinvasive cervical carcinoma and cervical intraepithelial neoplasia: biologic significance and clinical implications of 72-kDa metalloproteinase immunostaining.
Paralysis
Covalent modifiers of Botulinum neurotoxin counteract toxin persistence.
Tables of Toxicity of Botulinum and Tetanus Neurotoxins.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
Paraplegia
Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential.
Molecular and functional analyses of the human and mouse genes encoding AFG3L1, a mitochondrial metalloprotease homologous to the human spastic paraplegia protein.
Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28.
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease.
Paraproteinemias
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Parasitic Diseases
In vitro cytocidal effects on Trypanosoma brucei and inhibition of Leishmania major GP63 by peptidomimetic metalloprotease inhibitors.
Parathyroid Neoplasms
Biomarkers of parathyroid carcinoma.
Paratuberculosis
Mycobacterium paratuberculosis and inflammatory bowel disease: frequency distribution in serial colonoscopic biopsies using the polymerase chain reaction.
Pemphigoid, Bullous
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
Periapical Diseases
Sonic extracts from a bacterium related to periapical disease activate gelatinase A and inactivate tissue inhibitor of metalloproteinases TIMP-1 and TIMP-2.
Perinatal Death
A homozygous ZMPSTE24 null mutation in combination with a heterozygous mutation in the LMNA gene causes Hutchinson-Gilford progeria syndrome (HGPS): insights into the pathophysiology of HGPS.
Periodontal Diseases
Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study.
Elevated Levels of A Disintegrin and Metalloproteinase 8 in Gingival Crevicular Fluid of Patients With Periodontal Diseases.
Expression of collagenase and potential transcriptional factors c-fos and egr-1 in periodontal gingival fibroblasts.
Matrix metalloproteinase-8 levels in periodontal disease patients: A systematic review.
Periodontal disease and gene-expression levels of metalloendopeptidases in human buccal mucosal epithelium.
Presence of mast cells and the expression of metalloproteinase 9 in the gingiva of ovariectomized rats with periodontal disease.
The effects of the initial treatment phase and of adjunctive low-dose doxycycline therapy on clinical parameters and MMP-8, MMP-9, and TIMP-1 levels in the saliva and peripheral blood of patients with chronic periodontitis.
[Effect of the management of class I obesity with metformin on metalloproteinase activity in patients with chronic periodontitis].
Periodontal Pocket
Chlamydia pneumoniae together with collagenase-2 (MMP-8) in periodontal lesions.
Periodontitis
A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis.
A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System.
Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.
Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial.
Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis.
Membrane type (MT) 1-matrix metalloproteinase (MMP) and MMP-2 expression in ligature-induced periodontitis in the rat.
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease.
Salivary Matrix Metalloproteinase-8 and -9 and Myeloperoxidase in Relation to Coronary Heart and Periodontal Diseases: A Subgroup Report from the PAROKRANK Study (Periodontitis and Its Relation to Coronary Artery Disease).
Simvastatin modulates gingival cytokine and MMP production in a rat model of ligature-induced periodontitis.
Peripheral Arterial Disease
Abnormal circulating levels of metalloprotease 9 and its tissue inhibitor 1 in angiographically proven peripheral arterial disease: relationship to disease severity.
Increased pregnancy-associated plasma protein-A as a marker for peripheral atherosclerosis: results from the Linz Peripheral Arterial Disease Study.
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
Peripheral Nerve Injuries
Different expression of tissue inhibitor of metalloproteinase family members in rat dorsal root ganglia and their changes after peripheral nerve injury.
LLLT actives MMP-2 and increases muscle mechanical resistance after nerve sciatic rat regeneration.
Peritoneal Fibrosis
Genetic or pharmacologic blockade of enhancer of zeste homolog 2 inhibits the progression of peritoneal fibrosis.
The effects of interferon alpha2b on chemically-induced peritoneal fibrosis and on peritoneal tissue MMP-2 and TIMP-2 levels in rats.
Peritonitis
Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis.
Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage origin.
Pheochromocytoma
Differentiation of PC12 cells with nerve growth factor is associated with induction of transin synthesis and release.
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate.
Pick Disease of the Brain
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Pituitary Neoplasms
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pituitary Adenomas: Possible Markers of Neuroendocrine Cells.
plasmin deficiency
Functional overlap between two classes of matrix-degrading proteases in wound healing.
Pleural Effusion
Tissue inhibitor of metalloproteinase 2 (TIMP-2) expression in adenocarcinoma pleural effusions.
Pleural Effusion, Malignant
On the identification of biomarkers for non-small cell lung cancer in serum and pleural effusion.
Pneumococcal Infections
Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice.
Pneumonia
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.
Angiotensin-(1-7)/Mas Signaling Inhibits Lipopolysaccharide-Induced ADAM17 Shedding Activity and Apoptosis in Alveolar Epithelial Cells.
ApolipoproteinA-1 Overexpression Attenuates Cigarette Smoke Induced Emphysema in Mice.
Cleavage of the cell-surface O-sialoglycoproteins CD34, CD43, CD44, and CD45 by a novel glycoprotease from Pasteurella haemolytica.
Comparative effects of betamethasone, cyclosporin and nedocromil sodium in acute pulmonary inflammation and metalloproteinase activities in bronchoalveolar lavage fluid from mice exposed to lipopolysaccharide.
Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein.
Environmental arsenic exposure and sputum metalloproteinase concentrations.
Establishment of a young mouse model and identification of an allelic variation of zmpB in complicated pneumonia caused by Streptococcus pneumoniae.
Grape skin extract reduced pulmonary oxidative response in mice exposed to cigarette smoke.
Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.
Marked von Willebrand factor and factor VIII elevations in severe acute respiratory syndrome coronavirus-2-positive, but not severe acute respiratory syndrome coronavirus-2-negative, pneumonia: a case-control study.
Pathology, Tissue Metalloproteinase Transcription and Haptoglobin Responses in Mice after Experimental Challenge with Different Isolates of Pasteurella multocida Obtained from Cases of Porcine Pneumonia.
Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia.
Repeated cadmium nebulizations induce pulmonary MMP-2 and MMP-9 production and emphysema in rats.
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
The dsbB gene product is required for protease production by Burkholderia cepacia.
The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation.
Tissue inhibitor of metalloproteinase-1 deficiency amplifies acute lung injury in bleomycin-exposed mice.
[The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases].
Polycystic Kidney Diseases
A possible role for metalloproteinases in renal cyst development.
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis.
The epidermal growth factor receptor pathway in chronic kidney diseases.
Polycystic Kidney, Autosomal Dominant
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis.
The epidermal growth factor receptor pathway in chronic kidney diseases.
Polycystic Kidney, Autosomal Recessive
A novel inhibitor of tumor necrosis factor-alpha converting enzyme ameliorates polycystic kidney disease.
Polycystic Ovary Syndrome
Gingival Inflammation and Salivary or Serum Granulocyte Secreted Enzymes in Patients With Polycystic Ovary Syndrome.
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Polycythemia
Increased Pulmonary GM-CSF Causes Alveolar Macrophage Accumulation: Mechanistic Implications for Desquamative Interstitial Pneumonitis.
Polycythemia Vera
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Polymicrogyria
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Polyneuropathies
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies.
Porcine Reproductive and Respiratory Syndrome
Correction for Guo et al., Modulation of CD163 Expression by Metalloprotease ADAM17 Regulates Porcine Reproductive and Respiratory Syndrome Virus Entry.
Increased proteolytic activity and matrix metalloprotease expression in lungs during infection by porcine reproductive and respiratory syndrome virus.
Modulation of CD163 expression by metalloprotease ADAM17 regulates porcine reproductive and respiratory syndrome virus entry.
Prader-Willi Syndrome
Malignant fibrous histiocytoma-pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.
Pre-Eclampsia
ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
Association between matrix metalloproteinase (MMP)-2 polymorphisms and MMP-2 levels in hypertensive disorders of pregnancy.
Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia.
Association of Nitric Oxide Synthase and Matrix Metalloprotease Single Nucleotide Polymorphisms with Preeclampsia and Its Complications.
Comparative assessment of matrix metalloproteinase (MMP)-2 and MMP-9, and their inhibitors, tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 in preeclampsia and gestational hypertension.
Contribution of TIMP3 polymorphisms to the development of preeclampsia in Han Chinese women.
Downregulated Kruppel-Like Factor 8 Is Involved in Decreased Trophoblast Invasion Under Hypoxia-Reoxygenation Conditions.
Efficiency of first-trimester uterine artery Doppler, a-disintegrin and metalloprotease 12, pregnancy-associated plasma protein a, and maternal characteristics in the prediction of preeclampsia.
First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome.
First-trimester placental protein 13 and placental growth factor: markers for identification of women destined to develop early-onset pre-eclampsia.
First-trimester trophoblast cell model gene response to hypoxia.
Increased immunohistochemical expression of neutral metalloendopeptidase (enkephalinase; EC 3.4.24.11) in villi of the human placenta with pre-eclampsia.
Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy.
Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.
Metalloprotease (ADAM12-S) as a Predictor of Preeclampsia: Correlation with Severity, Maternal Complications, Fetal Outcome, and Doppler Parameters.
OS087. Maternal characteristics, mean arterial pressure and PLGF in early prediction of preeclampsia.
Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy.
Promoter hypomethylation of TIMP3 is associated with pre-eclampsia in a Chinese population.
Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia.
The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia.
Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo.
Can CD10 be used as a diagnostic marker in thyroid pathology?
CD10 (CALLA)/neutral endopeptidase 24.11 modulates inflammatory peptide-induced changes in neutrophil morphology, migration, and adhesion proteins and is itself regulated by neutrophil activation.
CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung.
Endopeptidase-24.11 is suppressed in myelin-forming but not in non-myelin-forming Schwann cells during development of the rat sciatic nerve.
In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia.
Inhibition of CD10/neutral endopeptidase 24.11 promotes B-cell reconstitution and maturation in vivo.
Neutral endopeptidase modulates septic shock.
Neutral endopeptidase modulation of septic shock.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL.
Pregnancy, Ectopic
A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy.
Disintegrin and metalloprotease and ectopic pregnancy.
Immunohistochemical expression of matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in ruptured and non-ruptured tubal ectopic pregnancies.
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Premature Birth
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Tissue inhibitor of metalloproteinase-1 mRNA is specifically induced in lung tissue after birth.
Primary Myelofibrosis
Importance of plasma matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase (TIMP) in development of fibrosis in agnogenic myeloid metaplasia.
Plasma matrix metalloproteinase and tissue inhibitor of metalloproteinase in patients with agnogenic myeloid metaplasia or idiopathic primary myelofibrosis.
[Research progress on mechanism of bone marrow relapse in pediatric acute lymphoblastic leukemia].
Primary Ovarian Insufficiency
Association between tissue inhibitor of metalloproteinase (TIMP) genetic polymorphisms and primary ovarian insufficiency (POI).
Prion Diseases
Apparent Reduction of ADAM10 in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents.
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.
The sheddase ADAM10 is a potent modulator of prion disease.
Progeria
Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS).
Cell autonomous and systemic factors in progeria development.
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts.
Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice.
The structural basis of ZMPSTE24-dependent laminopathies.
Prostatic Intraepithelial Neoplasia
Immunohistochemical evaluation of type IV collagenase (72-kd metalloproteinase) in prostatic intraepithelial neoplasia.
Prostatic Neoplasms
ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer.
Amyloid precursor protein regulates migration and metalloproteinase gene expression in prostate cancer cells.
Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
Antimetastatic drugs in prostate cancer.
Aromatase-induced endogenous estrogen promotes tumour metastasis through estrogen receptor-?/matrix metalloproteinase 12 axis activation in castration-resistant prostate cancer.
Cerebral ischemic events in patients with advanced lung or prostate cancer.
Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients.
Collagen I and III and metalloproteinase gene and protein expression in prostate cancer in relation to Gleason score.
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.
Combined Dynamic Alterations in Urinary VEGF Levels and Tissue ADAM9 Expression as Markers for Lethal Phenotypic Progression of Prostate Cancer.
CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.
Design and synthesis of a novel BODIPY-labeled PSMA inhibitor.
Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression.
Differential regulation of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression in co-cultures of prostate cancer and stromal cells.
Effect of HUVEC apoptosis inducing proteinase from Vipera lebetina venom (VLAIP) on viability of cancer cells and on platelet aggregation.
Evidence for increased activated metalloproteinase 2 (MMP-2a) expression associated with human prostate cancer progression.
Expression of metalloproteinase genes in human prostate cancer.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer.
Herpesvirus saimiri (HVS)-based endothelin converting enzyme-1 (ECE-1) shRNA expression decreases prostate cancer cell invasion and migration.
Identification of ADAM12 as a Novel Basigin Sheddase.
Integrin ?7 Binds Tissue Inhibitor of Metalloproteinase 3 to Suppress Growth of Prostate Cancer Cells.
Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration.
Metalloproteinase 11, potential marker and molecular target in advanced and castration-resistant prostate cancer. Culture study of peritumoral fibroblasts.
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.
Osteonectin promotes prostate cancer cell migration and invasion: a possible mechanism for metastasis to bone.
Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer.
Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers.
Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17.
Prognostic significance of matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expression in prostate cancer.
Promatrilysin expression is induced by fibroblast growth factors in the prostatic carcinoma cell line LNCaP but not in normal primary prostate epithelial cells.
Prostate-specific antigen in serum occurs predominantly in complex with alpha 1-antichymotrypsin.
PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9.
Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence.
Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis.
Synthetic inhibitor of matrix metalloproteases decreases tumor growth and metastases in a syngeneic model of rat prostate cancer in vivo.
The role of an 80 kDa fragment of E-cadherin in the metastatic progression of prostate cancer.
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression.
Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase.
Prostatitis
Effects of aging and castration on plasminogen activator and metalloprotease activities in the rat prostate complex.
ZapA, a virulence factor in a rat model of Proteus mirabilis-induced acute and chronic prostatitis.
Proteinuria
Angiotensin in progressive renal diseases: theory and practice.
Distinct actions of ETA selective versus combined ETA/ETB receptor antagonists in early diabetic kidney disease.
Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis.
Ureic clearance granule, alleviates renal dysfunction and tubulointerstitial fibrosis by promoting extracellular matrix degradation in renal failure rats, compared with enalapril.
Psoriasis
ADAM33 as a Psoriasis Susceptibility Gene in the Han Population of Northeastern China.
Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes.
Cutaneous Expression of A Disintegrin-like and Metalloprotease domain containing Thrombospondin Type 1 motif-like 5 (ADAMTSL5) in Psoriasis goes beyond Melanocytes.
Targeting miR-21 to treat psoriasis.
Pterygium
UVB-elicited induction of MMP-1 expression in human ocular surface epithelial cells is mediated through the ERK1/2 MAPK-dependent pathway.
Pulmonary Disease, Chronic Obstructive
A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD.
A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.
A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India.
A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
A Novel Macrolide Solithromycin Exerts Superior Anti-inflammatory Effect via NF-?B Inhibition.
A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).
ADAM17 Deficiency Protects against Pulmonary Emphysema.
All trans-retinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells.
An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse.
Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis.
Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls.
Association of a disintegrin and metalloproteinase 33 (ADAM33) gene polymorphisms with chronic obstructive pulmonary disease in the Chinese population: a meta-analysis.
Comparison of arterial and venous blood biomarker levels in chronic obstructive pulmonary disease.
Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung.
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
DNA sequence variations of metalloproteinases: their role in asthma and COPD.
Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.
Elevated serum matrix metalloprotease (MMP-2) as a candidate biomarker for stable COPD.
Experimental Pneumocystis lung infection promotes M2a alveolar macrophage-derived MMP12 production.
Gelatinolytic activity in tracheal epithelial lining fluid and in blood from horses with chronic obstructive pulmonary disease.
Genetic Variants in IL6R and ADAM19 are Associated with COPD Severity in a Mexican Mestizo Population.
In Utero Exposure to Second-Hand-Smoke (SHS) Aggravates Adult Responses to Irritants: I. Adult SHS.
Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications.
Polymorphisms in a disintegrin and metalloprotease 33 gene and the risk of chronic obstructive pulmonary disease: A meta-analysis.
Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients.
Quantitative proteomic characterization of the lung extracellular matrix in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.
Serological investigation of the collagen degradation profile of patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis.
Single nucleotide polymorphisms V4 and T1 of the ADAM33 gene in Venezuelan patients with asthma or chronic obstructive pulmonary disease.
Specific IgA and metalloproteinase activity in bronchial secretions from stable chronic obstructive pulmonary disease patients colonized by Haemophilus influenzae.
Sputum Inflammometry to Manage Chronic Obstructive Pulmonary Disease Exacerbations: Beyond Guidelines.
The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.
Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD.
Variability in proteinase-antiproteinase balance, nutritional status, and quality of life in stable chronic obstructive pulmonary disease due to tobacco and nontobacco etiology.
[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease].
[Effects of Shenqi Bufei Tang on expessions of NF-kappaB, MMP-9 and TIMP-1 in airway remodeling of COPD rat model with lung-Qi deficiency syndrome]
[Effects of shuxuening injection on the levels of serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in acute exacerbated chronic obstructive pulmonary disease patients].
[Markers of airway remodeling in induced sputum from healthy smokers]
[Study on effect of anemoside B4 in improving COPD rats by regulating IL-12/STAT4 and IL-4/STAT6 signaling pathways].
[The analysis of amount of matrix metalloproteinase 1 precursor, metalloproteinase 1 tissue inhibitor and cystatin C in the bronchoalveolar secretion of patients with nonspecific lung diseases].
Pulmonary Edema
Polymorphisms of the Tissue Inhibitor of Metalloproteinase 3 Gene Are Associated with Resistance to High-Altitude Pulmonary Edema (HAPE) in a Japanese Population: A Case Control Study Using Polymorphic Microsatellite Markers.
Pulmonary Embolism
Evaluation of Pregnancy-Associated Plasma Protein-A Levels in Patients with Chronic Obstructive Pulmonary Disease and Associations with Disease Severity.
Isolation of a Novel Metalloproteinase from Agkistrodon Venom and Its Antithrombotic Activity Analysis.
Metalloproteinase inhibition protects against cardiomyocyte injury during experimental acute pulmonary thromboembolism.
Pulmonary Emphysema
Atorvastatin and Simvastatin Promoted Mouse Lung Repair After Cigarette Smoke-Induced Emphysema.
Selective MMP-12 inhibitors: WO-2008057254.
The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema.
[Occupational exposure to respiratory irritants and chronic obstructive pulmonary disease]
Pulmonary Eosinophilia
Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.
Pulmonary Fibrosis
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans.
Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages.
MiR-34b-5p knockdown attenuates bleomycin-induced pulmonary fibrosis by targeting tissue inhibitor of metalloproteinase 3 (TIMP3).
Role of MMP-2 in alveolar epithelial cell repair after bleomycin administration in rabbits.
Suppressor of cytokine signaling 1-modulated metalloproteinases and tissue inhibitor of metalloproteinase in pulmonary fibrosis.
[The changes of expression level of matrix metalloprotease 9 and its inhibitor (TIMP-1) in murine pulmonary fibrosis model]
Purpura
Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events.
DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related?
Effectiveness of Caplacizumab Nanobody in Acquired Thrombotic Thrombocytopenic Purpura Refractory to Conventional Treatment.
Emerging roles of adjunct therapies in acquired thrombotic thrombocytopenia purpura.
Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy.
Long-term remission of recurrent thrombotic thrombocytopenic purpura (TTP) after rituximab in children and young adults.
Purpura, Thrombocytopenic
ADAMTS13 turns 3.
ADAMTS13--more than just TMA and TTP.
Purpura, Thrombocytopenic, Idiopathic
A successfully treated case of an acute presentation of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) with decreased ADAMTS13 during late stage of pregnancy.
Purpura, Thrombotic Thrombocytopenic
A common origin of the 4143insA ADAMTS13 mutation.
A human monoclonal antibody against the distal carboxyl terminus of ADAMTS-13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura.
A multi-center evaluation of TECHNOSCREEN® ADAMTS-13 activity assay as a screening tool for detecting deficiency of ADAMTS-13.
A multicenter laboratory assessment of a new automated chemiluminescent assay for ADAMTS13 activity.
A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13.
Absence of exaggerated pharmacology by recombinant ADAMTS13 in the rat and monkey.
Acquired Thrombotic Thrombocytopenic Purpura Without Anti-ADAMTS13 Antibody Caused by Influenza A (H1N1) Virus Successfully Treated by Plasma Exchange: A Case Report.
Acute thrombotic thrombocytopenic purpura following orthopedic surgery.
Acute thrombotic thrombocytopenic purpura following orthopedic surgery: a case report.
ADAMTS-13 antigen and activity levels in thrombocytopenic disorders including thrombotic thrombocytopenic purpura in Kuwait.
ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.
ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies.
ADAMTS13 autoantibodies in patients with thrombotic microangiopathies and other immunomediated diseases.
ADAMTS13 content in plasma-derived factor VIII/von Willebrand factor concentrates.
ADAMTS13 kinetics after therapeutic plasma exchange and plasma infusion in patients with Upshaw-Schulman syndrome.
ADAMTS13 related markers and von Willebrand factor in plasma from patients with thrombotic microangiopathy (TMA).
ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment.
Aggressive Disease and Rare Sequelae in a Unique Case of Atypical Hemolytic Uremic Syndrome Secondary to Adult Onset Still's Disease.
An enzyme immunoassay of ADAMTS13 distinguishes patients with thrombotic thrombocytopenic purpura from normal individuals and carriers of ADAMTS13 mutations.
An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.
An inquiry into the relationship between ABO blood group and thrombotic thrombocytopenic purpura.
An update on the pathogenesis and management of acquired thrombotic thrombocytopenic purpura.
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura.
Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombocytopenic purpura.
Atypical hemolytic uremic syndrome: a syndrome in need of clarity.
Autopsy case of sudden maternal death from thrombotic thrombocytopenic purpura.
Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Bortezomib in the treatment of refractory thrombotic thrombocytopenic purpura.
Caplacizumab in adult patients with acquired thrombotic thrombocytopenic purpura.
Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura.
CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides.
Changes in health and disease of the metalloprotease that cleaves von Willebrand factor.
Characterization of conformation-sensitive antibodies to ADAMTS13, the von Willebrand cleavage protease.
Chest pain with increased troponin level; not always a cardiology issue.
Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.
Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.
Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies.
Cleavage of von Willebrand factor by ADAMTS-13 on endothelial cells.
Clinical experience in treatment of thrombotic thrombocytopenic purpura--hemolytic uremic syndrome with 28 patients.
Clinical features and outcomes in patients with thrombotic microangiopathy not associated with severe ADAMTS13 deficiency.
Cocaine-induced microangiopathic hemolytic anemia mimicking idiopathic thrombotic thrombocytopenic purpura: A case report and review of the literature.
Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura.
Congenital Thrombotic Thrombocytopenic Purpura Associated With Moyamoya Syndrome in a 3-Year-Old Girl: A Case Report.
Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene.
Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.
Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Cost-effectiveness of thrombotic thrombocytopenic purpura diagnosis: a retrospective analysis in the University Hospital Center of Lyon (France).
COVID-19 as a Potential Trigger for Immune Thrombotic Thrombocytopenic Purpura and Reason for an Unusual Treatment: A Case Report.
Crystal Structures of Human ADAMTS-1 Reveal a Conserved Catalytic Domain and a Disintegrin-like Domain with a Fold Homologous to Cysteine-Rich Domains.
Current concepts in thrombotic thrombocytopenic purpura.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Decreased ADAMTS13 activity in plasma from patients with thrombotic thrombocytopenic purpura.
Decreased von Willebrand factor protease activity associated with thrombocytopenic disorders.
Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection.
Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay.
Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis.
Double positivity of anti-?2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody.
Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.
Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura.
Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy.
Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity.
Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Fatal hemolytic uremic syndrome associated with day care surgery and anaesthesia: a case report.
Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.
Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.
Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany.
Heparin-induced thrombocytopenia as a cause of prolonged low platelet count in a patient with thrombotic thrombocytopenic purpura treated with plasmapheresis.
High titers of inhibitors of von Willebrand factor-cleaving metalloproteinase in a fatal case of acute thrombotic thrombocytopenic purpura.
High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.
Histone-induced thrombotic thrombocytopenic purpura in adamts13-/- zebrafish depends on von Willebrand factor.
Identification of a crucial tryptophan residue in ADAMTS13 required for its secretion and enzymatic activity.
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients.
Immature platelet fraction can help adjust therapy in refractory thrombotic microangiopathic hemolytic anemia cases.
Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease.
Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.
Inherited thrombotic thrombocytopenic purpura in children.
Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review.
Insights into ADAMTS13 structure: impact on thrombotic thrombocytopenic purpura diagnosis and management.
Intravenous gamma globulin for thrombotic microangiopathy of unknown etiology.
Investigational drugs in thrombotic thrombocytopenic purpura.
Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia.
Mechanisms of microvascular thrombosis in thrombotic thrombocytopenic purpura.
N-Acetylcysteine for Relapsing Thrombotic Thrombocytopenic Purpura: More Evidence of a Promising Drug.
N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity.
Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura.
Novel Heterozygous Mutations of Congenital Thrombotic Thrombocytopenic Purpura: A Rare Case Report.
Novel therapeutic approaches for thrombotic thrombocytopenic purpura.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Pathophysiology of thrombotic thrombocytopenic purpura.
Plasma Levels of Big Endothelin-1 Are Associated with Renal Insufficiency and In-Hospital Mortality of Immune Thrombotic Thrombocytopenic Purpura.
Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro.
Potential role of ADAMTS13 in the progression of alcoholic hepatitis.
Presenting ADAMTS13 on a TTP-associated MHC.
Presumed antiphospholipid syndrome and thrombotic thrombocytopenic purpura: An infrequent association.
Rapid quantitative assay of ADAMTS13 activity on an automated coagulation analyzer: clinical applications and comparison with immunoblot method.
Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.
Recurrent idiopathic thrombotic thrombocytopenic purpura: a role for vaccination in disease relapse?
Reduced ADAMTS13 activity in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.
Remission of Severe, Relapsed, and Refractory TTP after Multiple Cycles of Bortezomib.
Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency.
Rituximab can be combined with daily plasma exchange to achieve effective B-cell depletion and clinical improvement in acute autoimmune TTP.
Rituximab induces remission of cerebral ischemia caused by thrombotic thrombocytopenic purpura.
Rituximab was effective on refractory thrombotic thrombocytopenic purpura but induced a flare of hemophagocytic syndrome in a patient with systemic lupus erythematosus.
Rituximab-refractory thrombotic thrombocytopenic purpura responsive to intravenous but not subcutaneous bortezomib.
Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report.
Structure of von Willebrand factor-cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura.
Successful management of three patients with autoimmune thrombotic thrombocytopenic purpura with paradigm-changing therapy: Caplacizumab, steroids, plasma exchange, rituximab, and intravenous immunoglobulins (CASPERI).
The ADAMTS13(1239-1253) peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope.
The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpura.
The course of ADAMTS-13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine.
The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical andin silico study.
The genetics and pathogenesis of haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura.
The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians.
The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice.
The role of ADAMTS13 in the pathogenesis of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.
The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry.
The VWF/ADAMTS13 axis in the antiphospholipid syndrome: ADAMTS13 antibodies and ADAMTS13 dysfunction.
Thrombosis, Microangiopathies, and Inflammation.
Thrombotic microangiopathies assessment: mind the complement.
Thrombotic Thrombocytopenic Purpura and Anti-Thrombotic Therapy Targeted to Von Willebrand Factor.
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
Thrombotic thrombocytopenic purpura during pregnancy versus imitator of preeclampsia.
Thrombotic thrombocytopenic purpura in a patient with rapidly progressive glomerulonephritis with both anti-glomerular basement membrane antibodies and myeloperoxidase anti-neutrophil cytoplasmic antibodies.
Thrombotic thrombocytopenic purpura in children.
Thrombotic Thrombocytopenic Purpura Masquerading as Acute Ischemic Stroke.
Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children.
Thrombotic Thrombocytopenic Purpura Treated with Rituximab Associated with Primary Sjögren's Syndrome and Primary Hypothyroidism.
Thrombotic thrombocytopenic purpura-what is new?
Thrombotic thrombocytopenic purpura: a diagnostic and therapeutic challenge.
Thrombotic Thrombocytopenic Purpura: Beyond Empiricism and Plasma Exchange.
Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Ultralarge von Willebrand factor multimers and normal ADAMTS13 activity in the umbilical cord blood.
Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions.
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome.
Upshaw-Schulman Syndrome With c.2728C>T Mutation in ADAMTS13 Gene.
von Willebrand factor and von Willebrand factor-cleaving metalloprotease activity in Escherichia coli O157:H7-associated hemolytic uremic syndrome.
Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura.
Von Willebrand factor: another janus-faced hemostasis protein.
VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
[Biological Function of CysR Domain of ADAMTS13].
[Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions].
[Diagnosis and treatment of thrombotic thrombocytopenic purpura].
[Exacerbation of cranial nerurological symptoms by platelet transfusion before the diagnosis of thrombotic thrombocytopenic purpura].
[Hereditary form of thrombotic thrombocytopenic purpura]
[Thrombotic microangiopathy].
Radicular Cyst
Modulation of Matrix Metalloproteinase 14, Tissue Inhibitor of Metalloproteinase 3, Tissue Inhibitor of Metalloproteinase 4, and Inducible Nitric Oxide Synthase in the Development of Periapical Lesions.
receptor protein-tyrosine kinase deficiency
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
Rectal Neoplasms
The matrix metalloproteinase-7 and pro-enzyme of metalloproteinase-1 as a potential marker for patients with rectal cancer without distant metastasis.
Renal Insufficiency
Application of antibody array technology in the analysis of urinary cytokine profiles in patients with chronic kidney disease.
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Selective Indole-Based ECE Inhibitors: Synthesis and Pharmacological Evaluation.
Systematic separation and purification of elastase, gelatinase (matrix metalloproteinase 9), and collagenase (matrix metalloproteinase 8) from polymorphonuclear leukocytes in dialyzers previously used by patients with renal failure.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Renal Insufficiency, Chronic
ADAMTS-13 deficiency: can it cause chronic renal failure?
Association between renal dysfunction and metalloproteinase (MMP)-9 activity in hypertensive patients.
Chronic renal disease: do metalloproteinase inhibitors have a demonstrable role in extracellular matrix accumulation?
Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Serum metalloproteinases MMP-2, MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in patients on hemodialysis.
Systemic inhibition of BMP1-3 decreases progression of CCl
The epidermal growth factor receptor pathway in chronic kidney diseases.
Reoviridae Infections
A functional role for ADAM10 in human immunodeficiency virus type-1 replication.
Reperfusion Injury
Dual role of matrix metalloprotease 9 in liver ischemia and reperfusion injury.
Effects of metalloproteinase inhibition in a murine model of renal ischemia-reperfusion injury.
Lung transplant ischemia reperfusion injury: metalloprotease inhibition down-regulates exposure of type V collagen, growth-related oncogene-induced neutrophil chemotaxis, and tumor necrosis factor-alpha expression.
Matrix metalloprotease 9 promotes liver recovery from ischemia and reperfusion injury.
Phosphoramidon, an endothelin converting enzyme inhibitor attenuates local gastric ischemia-reperfusion injury in rats.
Respiratory Distress Syndrome
Effect of polymyxin B-immobilized fiber on blood metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in acute respiratory distress syndrome patients.
Impact of Different Tidal Volume Levels at Low Mechanical Power on Ventilator-Induced Lung Injury in Rats.
Metalloproteinase inhibition prevents acute respiratory distress syndrome.
Neutral endopeptidase in serum samples from patients with adult respiratory distress syndrome. Comparison with angiotensin-converting enzyme.
Respiratory Hypersensitivity
ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease.
Retinal Diseases
Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion.
Retinal Neovascularization
Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays.
Efficacy of Prinomastat) (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization.
Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization.
[Advancement of targeting therapy for retinal neovascularization]
Retinal Vein Occlusion
Association of MMP2-1306C/T and TIMP2G-418C polymorphisms in retinal vein occlusion.
Retinoblastoma
Biomarkers of parathyroid carcinoma.
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
Hypoxia promotes invasion of retinoblastoma cells in vitro by upregulating HIF-1?/MMP9 signaling pathway.
[Analysis of angiogenesis associated factors of retinoblastoma cell line and tumor tissues]
Rheumatic Diseases
Changes in biochemical markers of joint tissue metabolism in a randomized controlled trial of glucocorticoid in early rheumatoid arthritis.
Role of Microparticles in the Pathogenesis of Inflammatory Joint Diseases.
[Metalloproteinase inhibition: therapeutic application in rheumatic diseases]
Rheumatic Heart Disease
Association of matrix metalloprotease 1, 3, and 12 polymorphisms with rheumatic heart disease in a Chinese Han population.
TGF-?1 and TIMP-4 regulate atrial fibrosis in atrial fibrillation secondary to rheumatic heart disease.
Rhinitis
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
Rhinitis, Allergic
ADAM33 polymorphisms and susceptibility to allergic rhinitis: a meta-analysis.
Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergic rhinitis: A meta-analysis.
Increased expression of a disintegrin and metalloprotease 8 in allergic rhinitis.
Nonasthmatic nasal polyposis patients with allergy exhibit greater epithelial MMP positivity.
Rickets
PHEX gene mutation in a Chinese family with six cases of X-linked hypophosphatemic rickets.
Rickets, Hypophosphatemic
FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.
Hereditary disorders of renal phosphate wasting.
Rosacea
Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea.
Salmonella Infections
Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-?B.
Sarcoidosis
Clinical significance of serum thermolysin-like metalloendopeptidase and its relationship to serum angiotensin converting enzyme in sarcoidosis.
Identification of a thermolysin-like metalloendopeptidase in serum: activity in normal subjects and in patients with sarcoidosis.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Pulmonary alveolar macrophages from patients with active sarcoidosis express type IV collagenolytic proteinase. An enzymatic mechanism for influx of mononuclear phagocytes at sites of disease activity.
The selected genetic polymorphisms of metalloproteinases MMP2, 7, 9 and MMP inhibitor TIMP2 in sarcoidosis.
Thermolysin-like serum metalloendopeptidase. A new marker for active sarcoidosis that complements serum angiotensin-converting enzyme.
[Change of matrix metalloproteinase-1 and matrix metalloproteinase-7 in serum and bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and sarcoidosis].
Sarcoidosis, Pulmonary
A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis.
Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis.
Sarcoma
A novel TIMP-insensitive type IV collagen-degrading metalloproteinase from murine metastatic sarcoma cells.
Inhibition of AIDS-Kaposi's sarcoma cell induced endothelial cell invasion by TIMP-2 and a synthetic peptide from the metalloproteinase propeptide: implications for an anti-angiogenic therapy.
Local activity of matrix metalloproteinases in a case of botryoid sarcoma.
Matrix metalloproteinase 2 secretion in WEHI 164 fibrosarcoma cells is nitric oxide-related and modified by morphine.
Metalloproteinase expression and prognosis in soft tissue sarcomas.
Novel role of microRNA-126 in digestive system cancers: From bench to bedside.
Osteosarcoma oncogene expression detected by in situ hybridization.
The effect of microRNA-330 replacement on inhibition of growth and migration in renal cancer cells.
Tissue and serum loss of metalloproteinase inhibitors in high grade soft tissue sarcomas.
Sarcoma, Avian
Augmentation of metalloproteinase (gelatinase) activity secreted from Rous sarcoma virus-infected cells correlates with transforming activity of src.
Fibronectin-degrading proteases from the membranes of transformed cells.
Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts.
Sarcoma, Ewing
Fas ligand is present in tumors of the Ewing's sarcoma family and is cleaved into a soluble form by a metalloproteinase.
Fas-mediated apoptosis in Ewing's sarcoma cell lines by metalloproteinase inhibitors.
Sarcoma, Kaposi
Human chorionic gonadotropin inhibits Kaposi's sarcoma associated angiogenesis, matrix metalloprotease activity, and tumor growth.
Sarcoma, Synovial
[Correlation between matrix metalloproteinases-2 and tissue inhibitor of metalloproteinase-2 expression, metastatic potential and tumor angiogenesis in synovial sarcoma and its prognostic significance]
Sarcopenia
Matrix metalloprotease 3 is associated with sarcopenia in rheumatoid arthritis - results from the CHIKARA study.
Schistosomiasis
Dynamics of collagen, MMP and TIMP gene expression during the granulomatous, fibrotic process induced by Schistosoma mansoni eggs.
Scleredema Adultorum
Scleredema adultorum: case report and demonstration of abnormal expression of extracellular matrix genes in skin fibroblasts in vivo and in vitro.
Scleritis
Stromelysin (matrix metalloproteinase-3) and tissue inhibitor of metalloproteinase (TIMP-1) mRNA expression in scleritis.
Scleroderma, Systemic
Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European caucasian population.
Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention.
Serum levels of tissue inhibitors of metalloproteinase 2 in patients with systemic sclerosis with duration more than 2 years: correlation with cardiac and pulmonary abnormalities.
Systemic sclerosis-endothelial cell antiangiogenic pentraxin 3 and matrix metalloprotease 12 control human breast cancer tumor vascularization and development in mice.
Seizures
Beta-dystroglycan as a target for MMP-9, in response to enhanced neuronal activity.
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior.
Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis.
Serum metalloproteinase 9 levels increase after generalized tonic-clonic seizures.
Sepsis
Actions of Vibrio vulnificus metalloprotease on human plasma proteinase-proteinase inhibitor systems: a comparative study of native protease with its derivative modified by polyethylene glycol.
Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain.
ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin) and endothelial dysfunction in sepsis: marker or culprit?
Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis.
Chemical modification of Vibrio vulnificus metalloprotease with activated polyethylene glycol.
Functional domains of a zinc metalloprotease from Vibrio vulnificus.
High growing ability of Vibrio vulnificus biotype 1 is essential for production of a toxic metalloprotease causing systemic diseases in humans.
Histamine-releasing reaction induced by the N-terminal domain of Vibrio vulnificus metalloprotease.
Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis.
Inhibitory effect of alpha 2-macroglobulin on Vibrio vulnificus protease.
Interaction of Bacteroides fragilis Toxin with Outer Membrane Vesicles Reveals New Mechanism of Its Secretion and Delivery.
Matrix- metalloproteinase -2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis.
Metalloprotease is not essential for Vibrio vulnificus virulence in mice.
Molecular Regulation of Acute Tie2 Suppression in Sepsis.
Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series.
Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C.
Risk stratification and prognostic evaluation of endothelial cell-specific molecule1, von Willebrand factor, and a disintegrin-like and metalloprotease with thrombospondin type 1 motif for sepsis in the emergency department: An observational study.
Serum haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) complex as a biomarker of systemic inflammation in cattle.
The N-terminal propeptide of Vibrio vulnificus extracellular metalloprotease is both an inhibitor of and a substrate for the enzyme.
The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
[Detection of Bacteroides fragilis enterotoxin from extraintestinal clinical isolates of B. fragilis group organisms]
Severe Acute Respiratory Syndrome
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19.
Severe Combined Immunodeficiency
Role of the matrix metalloproteinase and tissue inhibitors of metalloproteinase families in noninvasive and invasive tumors transplanted in mice with severe combined immunodeficiency.
Sexually Transmitted Diseases
Lower concentrations of chemotactic cytokines and soluble innate factors in the lower female genital tract associated with the use of injectable hormonal contraceptive.
Shock, Septic
Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide library.
Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome.
Modulation of plasma metalloproteinase-9 concentrations and peripheral blood monocyte mRNA levels in patients with septic shock: effect of fiber-immobilized polymyxin B treatment.
The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation.
Shoulder Pain
Functional staging and surgical intervention of the elbow and shoulder joints in a patient with rheumatoid arthritis.
Sjogren's Syndrome
[Viral Tax protein expression in salivary glands of patients infected with human t-cell lymphotropic virus type I and Sicca Syndrome.]
Skin Diseases
A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis.
Skin Neoplasms
Differential expression of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 in non-melanoma skin cancer: implications for tumour progression.
Small Cell Lung Carcinoma
Alternatives to chemotherapy and radiotherapy as adjuvant treatment for lung cancer.
Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells.
Smoldering Multiple Myeloma
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
snapalysin deficiency
Erratum to "Meprin Metalloprotease Deficiency Associated with Higher Mortality Rates and More Severe Diabetic Kidney Injury in Mice with STZ-Induced Type 1 Diabetes".
Spasm
Epitope Mapping of Tetanus Toxin by Monoclonal Antibodies: Implication for Immunotherapy and Vaccine Design.
Spinal Cord Injuries
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Cordycepin-enriched WIB-801C from Cordyceps militaris improves functional recovery by attenuating blood-spinal cord barrier disruption after spinal cord injury.
Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury.
Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions.
Spinal Dysraphism
Urinary TIMP-2 and MMP-2 are significantly associated with poor bladder compliance in adult patients with spina bifida.
Spondylitis, Ankylosing
[Effects of Bushen qiangdu decoction on MMP-9 and TIMP-1 produced by peripheral blood mononuclear cells in patients with ankylosing spondylitis].
Spondylosis
[Effects of Chiropractics on Intervertebral Disk Extracell Matrix and Metabolic Enzymes in Rats with Cervical Spondylosis].
Squamous Cell Carcinoma of Head and Neck
ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.
Expression of extracellular matrix metalloprotease inducer in laryngeal squamous cell carcinoma.
Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma.
Expression of membrane type I-matrix metalloproteinase in oral squamous cell carcinoma.
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Extracellular matrix metalloprotease inducer-expressing head and neck squamous cell carcinoma cells promote fibroblast-mediated type I collagen degradation in vitro.
Galectin-9 as an important marker in the differential diagnosis between oral squamous cell carcinoma, oral leukoplakia and oral lichen planus.
Increase of disintergin metalloprotease 10 (ADAM10) expression in oral squamous cell carcinoma.
Inhibition of head and neck squamous cell carcinoma growth and invasion by the calcium influx inhibitor carboxyamido-triazole.
Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts.
Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.
Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.
Modulation of tumor cell growth in vivo by extracellular matrix metalloprotease inducer.
MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.
Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function.
The immunohistochemical characterization of MMP-2, MMP-10, TIMP-1, TIMP-2, and podoplanin in oral squamous cell carcinoma.
Starvation
Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans.
Nutrient-regulated proteolysis of MrpC halts expression of genes important for commitment to sporulation during Myxococcus xanthus development.
Proteinase pattern in Trametes versicolor in response to carbon and nitrogen starvation.
Status Epilepticus
Epileptogenesis after traumatic brain injury in Plau-deficient mice.
Increased metalloproteinase activity in the hippocampus following status epilepticus.
Stomach Neoplasms
A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer.
ADAM 10 is associated with gastric cancer progression and prognosis of patients.
Cell proliferation, cell death, E-cadherin, metalloproteinase expression and angiogenesis in gastric cancer precursors and early cancer of the intestinal type.
Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis.
Helicobacter pylori promotes gastric cancer progression by upregulating semaphorin 5A expression via ERK/MMP9 signaling.
Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.
Melatonin indirectly decreases gastric cancer cell proliferation and invasion via effects on cancer-associated fibroblasts.
Prognostic Significance of ADAM17 for Gastric Cancer Survival: A Meta-Analysis.
Reduced expression of tissue inhibitor of metalloproteinase in nodal metastasis of stomach cancer.
Relation of matrilysin messenger RNA expression with invasive activity in human gastric cancer.
Thrombin conducts epithelial?mesenchymal transition via protease?activated receptor?1 in human gastric cancer.
Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer.
VEGF and metalloproteinase 2 (MMP 2) expression in gastric cancer tissue.
[New prognostic factors in human gastric carcinomas]
Stomach Ulcer
Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence.
Stroke
A matrix metalloproteinase protein array reveals a strong relation between MMP-9 and MMP-13 with diffusion-weighted image lesion increase in human stroke.
ADAMTS12, a new candidate gene for pediatric stroke.
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology.
Angiogenesis-Related Genes in Endothelial Progenitor Cells May Be Involved in Sickle Cell Stroke.
Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke.
Cerebral ischemic events in patients with advanced lung or prostate cancer.
Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model.
Extracellular proteolytic pathophysiology in the neurovascular unit after stroke.
Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.
Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke.
Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study.
Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?
Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke.
Rare Variants in the ADAMTS13 Von Willebrand Factor-Binding Domain Contribute to Pediatric Stroke.
Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice.
Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents.
Role of HIF-1?-activated Epac1 on HSC-mediated neuroplasticity in stroke model.
Role of reduced ADAMTS13 in arterial ischemic stroke: a pediatric cohort study.
Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study.
Serum matrix metalloproteinase-8, tissue inhibitor of metalloproteinase and myeloperoxidase in ischemic stroke.
Sonographic monitoring of mass effect in stroke patients treated with hypothermia. Correlation with intracranial pressure and matrix metalloproteinase 2 and 9 expression.
The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activities in vitro.
[Advances in the biochemical markers of complications associated with carotid endarterectomy].
[Exacerbation of cranial nerurological symptoms by platelet transfusion before the diagnosis of thrombotic thrombocytopenic purpura].
Strongyloidiasis
Strongyloides stercoralis: identification of a protease that facilitates penetration of skin by the infective larvae.
Subarachnoid Hemorrhage
The changes of von willebrand factor/a disintegrin-like and metalloprotease with thrombospondin type I repeats-13 balance in aneurysmal subarachnoid hemorrhage.
Synovitis
Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis.
Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis.
The ADAM12 is upregulated in synovitis and postinflammatory fibrosis of the synovial membrane in patients with early radiographic osteoarthritis.
Syphilis
Treponema pallidum enhances human monocyte migration and invasion by dysregulating the MMP/TIMP balance.
Tachycardia, Ventricular
Serum BNP, hs-C-reactive protein, procollagen to assess the risk of ventricular tachycardia in ICD recipients after myocardial infarction.
Telangiectasia, Hereditary Hemorrhagic
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Telangiectasis
Deciphering the vascular labyrinth: role of microRNAs and candidate gene SNPs in brain AVM development - literature review.
Temporomandibular Joint Disorders
Expression of collagenases (matrix metalloproteinase-1, 8, 13) and tissue inhibitor of metalloproteinase-1 of retrodiscal tissue in temporomandibular joint disorder patients.
Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders.
Tendinopathy
Mini-Review: Toxic Tendinopathy.
Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats.
Teratoma
Tissue inhibitor of metalloproteinase proteins inhibit teratoma growth in mice transplanted with pluripotent stem cells.
Tetanus
A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity.
Analysis of the structure and expression of the VAMP family of synaptic vesicle proteins.
Bacterial toxins: an overview on bacterial proteases and their action as virulence factors.
Cell swelling-induced signaling for insulin secretion bypasses steps involving G proteins and PLA2 and is N-ethylmaleimide insensitive.
Cleavage of cellubrevin by tetanus toxin does not affect fusion of early endosomes.
Human monoclonal ScFv that inhibits cellular entry and metalloprotease activity of tetanus neurotoxin.
Intracellular targets and metalloprotease activity of tetanus and botulism neurotoxins.
Residual enzymatic activity of the tetanus toxin light chain present in tetanus toxoid batches used for vaccine production.
Tables of Toxicity of Botulinum and Tetanus Neurotoxins.
TETANUS and TETANUS NEUROTOXIN: from peripheral uptake to central nervous tissue targets.
Tetanus neurotoxin-induced epilepsy in mouse visual cortex.
Tetanus toxin as a neurobiological tool to study mechanisms of neuronal cell death in the mammalian brain.
Tetanus toxin light chain expression in Sertoli cells of transgenic mice causes alterations of the actin cytoskeleton and disrupts spermatogenesis.
The role of transglutaminase in the mechanism of action of tetanus toxin.
Theileriasis
A role for matrix metalloproteinases in the pathology and attenuation of Theileria annulata infections.
Thrombocytopenia
A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
A Difficult Diagnosis Case of Prolonged Thrombocytopenia With Sepsis and Disseminated Intravascular Coagulation.
Assessment and Monitoring of Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): Strategies to Improve Outcomes.
Bothrops asper metalloproteinase BaP1 is inhibited by alpha(2)-macroglobulin and mouse serum and does not induce systemic hemorrhage or coagulopathy.
Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura.
Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Emerging roles of adjunct therapies in acquired thrombotic thrombocytopenia purpura.
Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease.
Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Investigational drugs in thrombotic thrombocytopenic purpura.
Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy.
Linear relationship between ADAMTS13 activity and platelet dynamics even before severe thrombocytopenia.
New developments in treatment modalities of thrombotic thrombocytopenic purpura.
Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of history of splenectomy: the significance of ADAMTS13 and graft function.
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.
Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature.
Secondary thrombotic microangiopathy with severely reduced ADAMTS13 activity in a patient with Capnocytophaga canimorsus sepsis: a case report.
Silent Thrombotic Thrombocytopenic Purpura: PLASMIC, Lessons Learned, and Current Management Overview.
Sjögren's syndrome initially presented as thrombotic thrombocytopenic purpura in a male patient: a case report and literature review.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage.
Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Thrombophilia
ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma.
Thrombosis
Actin polymerization regulates glycoprotein Ib? shedding.
ADAMTS-13 in the Diagnosis and Management of Thrombotic Microangiopathies.
ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis.
ADAMTS13 exerts a thrombolytic effect in microcirculation.
ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice.
ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.
ADAMTS13: An Emerging Target in Stroke Therapy.
AFM Imaging Reveals Multiple Conformational States of ADAMTS13.
Allosteric activation of ADAMTS13 by von Willebrand factor.
Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction.
Balance between von Willebrand factor and ADAMTS13 following major partial hepatectomy.
Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.
Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.
Characterization of 'basparin A,' a prothrombin-activating metalloproteinase, from the venom of the snake Bothrops asper that inhibits platelet aggregation and induces defibrination and thrombosis.
Characterization of the interactions of ADAMTS13 CUB1 domain to WT- and GOF-Spacer domain by molecular dynamics simulation.
Chimeric derivative of fibrolase, a fibrinolytic enzyme from southern copperhead venom, possesses inhibitory activity on platelet aggregation.
Clinical utility of novel agents in the treatment of central venous catheter occlusion.
Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus.
Congenital ADAMTS-13 deficiency presenting as life-threatening thrombosis during pregnancy.
Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Current concepts in thrombotic thrombocytopenic purpura.
Destabilization of the von Willebrand factor A2 domain under oxidizing conditions investigated by molecular dynamics simulations.
Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease.
Effect of recombinant ADAMTS13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage.
Emerging technologies in hemostasis diagnostics: a report from the Australasian Society of Thrombosis and Haemostasis Emerging Technologies Group.
Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity.
Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis.
Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease.
Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura.
Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.
High levels of von Willebrand factor and low levels of its cleaving protease, ADAMTS13, are associated with stroke in young HIV-infected patients.
In pursuit of small molecule chemistry for calcium-permeable non-selective TRPC channels - mirage or pot of gold?
In vivo imaging analysis of the interaction between unusually large von Willebrand factor multimers and platelets on the surface of vascular wall.
Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model.
Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms.
Isolation of a Novel Metalloproteinase from Agkistrodon Venom and Its Antithrombotic Activity Analysis.
Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: The MESA-RV Study.
MMP-13 binds to platelet receptors ?IIb?3 and GPVI and impairs aggregation and thrombus formation.
Molecular biology of ADAMTS13 and diagnostic utility of ADAMTS13 proteolytic activity and inhibitor assays.
MR imaging of iron phagocytosis in intraluminal thrombi of abdominal aortic aneurysms in humans.
Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice.
Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation.
Plasma von Willebrand Factor and a Disintegrin and Metalloproteinase with Eight Thrombospondin-type 1 Motif Levels in Hemodialysis Patients: Relation to Vascular Access Thrombosis.
Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice.
Reference range for ADAMTS13 antigen, activity and anti-ADAMTS13 antibody in the healthy adult Singapore population.
Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury.
SNPs in ADAMTS13.
Thrombotic Thrombocytopenic Purpura and Anti-Thrombotic Therapy Targeted to Von Willebrand Factor.
Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Von Willebrand Factor and ADAMTS13 and long-term outcomes in patients undergoing percutaneous coronary intervention.
Von Willebrand Factor Deposition and ADAMTS-13 Consumption in Allograft Tissue of Thrombotic Microangiopathy-like Disorder After Living Donor Liver Transplantation: A Case Report.
Von Willebrand factor:antigen and ADAMTS-13 level, but not soluble P-selectin, are risk factors for the first asymptomatic deep vein thrombosis in cancer patients undergoing chemotherapy.
[Should we begin with statin therapy in acute coronary syndrome?]
[Stable expression and characterization of the von Willebrand factor cleaving protease]
Thrombotic Microangiopathies
A Case of Recurrent Thrombotic Microangiopathy Caused by Hypertensive Urgency.
A human monoclonal antibody against the distal carboxyl terminus of ADAMTS-13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura.
A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13.
Acquired Thrombotic Thrombocytopenic Purpura Without Anti-ADAMTS13 Antibody Caused by Influenza A (H1N1) Virus Successfully Treated by Plasma Exchange: A Case Report.
ADAMTS-13 deficiency: can it cause chronic renal failure?
ADAMTS13 missense variants associated with defective activity and secretion of ADAMTS13 in a patient with non-cirrhotic portal hypertension.
ADAMTS13 related markers and von Willebrand factor in plasma from patients with thrombotic microangiopathy (TMA).
ADAMTS13--more than just TMA and TTP.
Assessment and Monitoring of Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura (iTTP): Strategies to Improve Outcomes.
Attending rounds: microangiopathic hemolytic anemia with renal insufficiency.
Autoimmune thrombotic microangiopathy: advances in pathogenesis, diagnosis, and management.
Chest pain with increased troponin level; not always a cardiology issue.
Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.
Clinical characteristics and outcomes of thrombotic microangiopathy in Malaysia.
Clinical features and outcomes in patients with thrombotic microangiopathy not associated with severe ADAMTS13 deficiency.
Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura.
Complete defect in vWF-cleaving protease activity associated with increased shear-induced platelet aggregation in thrombotic microangiopathy.
Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.
Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay.
Donor Age Affects Liver Regeneration during Early Period in the Graft Liver and Late Period in the Remnant Liver after Living Donor Liver Transplantation.
Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy.
Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity.
Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.
Heparin-induced thrombocytopenia as a cause of prolonged low platelet count in a patient with thrombotic thrombocytopenic purpura treated with plasmapheresis.
Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy.
Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review.
Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.
Intensive plasma exchange increases ADAMTS-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.
Investigational drugs in thrombotic thrombocytopenic purpura.
Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
Novel therapeutic approaches for thrombotic thrombocytopenic purpura.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Pathogenesis of thrombotic thrombocytopenic purpura.
Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.
Performance of Diagnostic Scores in Thrombotic Microangiopathy Patients in the Intensive Care Unit: A Monocentric Study.
Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C.
Renal thrombotic microangiopathy and pulmonary arterial hypertension in a patient with late-onset cobalamin C deficiency.
Structure and Proteolytic Properties of ADAMTS13, A Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies.
The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical andin silico study.
The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians.
The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry.
Thrombotic microangiopathies: multimers, metalloprotease, and beyond.
Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy.
Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies.
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions.
[Clinical observation of a patient with thrombotic thrombocytopenic purpura with renal and intestinal lesions].
[Diagnosis and treatment of thrombotic thrombocytopenic purpura].
[Expression of the metalloproteinase domain of von Willebrand factor-cleaving protease and preparation of its McAb]
Thymoma
Clinical significance of tissue inhibitor of metalloproteinase and matrix metalloproteinase mRNA expression in thymoma.
Inherited lipodystrophies and hypertriglyceridemia.
Lipodystrophies: Disorders of adipose tissue biology.
p28(GANK) overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1? pathways.
p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1? pathways.
Thyroid Cancer, Papillary
Assessment of biomarkers for clinical diagnosis of papillary thyroid carcinoma with distant metastasis.
[Gene expression of metalloproteinase 11, claudin 1 and selected adhesion related genes in papillary thyroid cancer.]
Thyroid Neoplasms
Cell surface and secreted protein profiles of human thyroid cancer cell lines reveal distinct glycoprotein patterns.
Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications.
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in thyroid C-cells and medullary thyroid carcinomas.
Ratio of metalloproteinase 2 to tissue inhibitor of metalloproteinase 2 in medullary thyroid carcinoma.
Tinea
Humoral and cellular immune response to a Microsporum canis recombinant keratinolytic metalloprotease (r-MEP3) in experimentally infected guinea pigs.
Isolation of a promoter region of a secreted metalloprotease gene from Microsporum canis.
[The relation between the growth and extracellular proteolytic activity in trichophyton rubrum, comparing isolates from granuloma trichophyticum with tinea superficialis]
Tooth Mobility
Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1.
Toxemia
Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.
Trachoma
Cytokine and fibrogenic gene expression in the conjunctivas of subjects from a Gambian community where trachoma is endemic.
Trichiasis
Oral doxycycline for the prevention of postoperative trachomatous trichiasis in Ethiopia: a randomised, double-blind, placebo-controlled trial.
Trichomonas Infections
The 50kDa metalloproteinase TvMP50 is a zinc-mediated Trichomonas vaginalis virulence factor.
TvMP50 is an immunogenic metalloproteinase during male trichomoniasis.
Triple Negative Breast Neoplasms
Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.
N-glycosylation regulates ADAM8 processing and activation.
Tuberculosis
Crystal structure of Mycobacterium tuberculosis ZMP1, a metalloprotease involved in pathogenicity.
Deletion of zmp1 improves Mycobacterium bovis BCG-mediated protection in a guinea pig model of tuberculosis.
Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor.
M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates.
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases Are Potential Biomarkers of Pulmonary and Extra-Pulmonary Tuberculosis.
Mycobacterium tuberculosis alters the metalloprotease activity of the COP9 signalosome.
Mycobacterium tuberculosis Rv0198c, a putative matrix metalloprotease is involved in pathogenicity.
Mycobacterium tuberculosis, but not vaccine BCG, specifically upregulates matrix metalloproteinase-1.
Novel thiazolidinedione-hydroxamates as inhibitors of Mycobacterium tuberculosis virulence factor Zmp1.
Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis.
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states.
Tuberculosis, Pulmonary
[The system of matrix metalloproteinases and their role in patients with pulmonary tuberculosis].
Tuberculosis, Spinal
Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.
Unconsciousness
[Immunohistochemical findings in prolonged cerebral hypoxia]
Uremia
Serum type III, IV collagens and TIMP in patients with type II diabetes mellitus.
Ureteral Obstruction
Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction.
Partial ureteral obstruction dysregulates the renal renin-angiotensin system in the fetal sheep kidney.
Urinary Bladder Neoplasms
A novel approach to using matrix metalloproteinases for bladder cancer.
Dual tumor-suppressors miR-139-5p and miR-139-3p targeting matrix metalloprotease 11 in bladder cancer.
Evaluation of MMP-2, MMP-9, TIMP-1, TIMP-2, NGAL and MMP-9/NGAL complex in urine and sera from patients with bladder cancer.
Expression and Clinical Significance of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and a Disintegrin and Metalloproteinase with Thrombospondin Type 1 Motif 1 (ADAMTS1) in Post-Kidney-Transplant Bladder Tumors.
Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma.
Purification of a gelatin-degrading type IV collagenase secreted by ras oncogene-transformed fibroblasts.
Role of serum and urine transforming growth factor beta 1, matrix metallopeptidase 9, tissue inhibitor of metalloproteinase 2, and nerve growth factor beta levels and serum neutrophil-to-lymphocyte ratio in predicting recurrence and progression risks in patients with primary non-muscle invasive bladder cancer.
Significance of collagenase 3 (matrix metalloproteinase 13) in invasive bladder cancer: correlation with pathological parameters.
The importance of integrin-linked kinase in the regulation of bladder cancer invasion.
The microRNA miR-3174 Suppresses the Expression of ADAM15 and Inhibits the Proliferation of Patient-Derived Bladder Cancer Cells.
Urinary Incontinence
Differences in estrogen modulation of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-1 expression in cultured fibroblasts from continent and incontinent women.
Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?
The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of uterosacral and cardinal ligaments in the etiopathogenesis of pelvic organ prolapse among women without stress urinary incontinence.
Uterine Cervical Neoplasms
A novel role of metalloproteinase in cancer-mediated immunosuppression.
Anti-tumor activity of staurosporine in the tumor microenvironment of cervical cancer: An in vitro study.
Diagnostic Power of Cytokine M-CSF, Metalloproteinase 2 (MMP-2) and Tissue Inhibitor-2 (TIMP-2) in Cervical Cancer Patients Based on ROC Analysis.
Human papillomavirus E6-regulated microRNA-20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2.
Immunohistochemical detection of matrix metalloproteinases (MMP) 1 and 2, and tissue inhibitor of metalloproteinase 2 (TIMP 2) in stage IB cervical cancer.
MicroRNA-21 promotes proliferation, migration, and invasion of cervical cancer through targeting TIMP3.
No Association of Matrix Metalloproteinase [MMP]-2 (-735C > T) and Tissue Inhibitor of Metalloproteinase [TIMP]-2 (-418G > C) Gene Polymorphisms with Cervical Cancer Susceptibility.
Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling.
Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial.
The foundations of successful RT in situ PCR.
Uveitis
Identification of Autoantigens in Body Fluids by Combining Pull-Downs and Organic Precipitations of Intact Immune Complexes with Quantitative Label-Free Mass Spectrometry.
Vaccinia
Mutational analysis of the potential catalytic residues of the VV G1L metalloproteinase.
Vaccinia virus G1 protein, a predicted metalloprotease, is essential for morphogenesis of infectious virions but not for cleavage of major core proteins.
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Varicose Ulcer
Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds.
Varicose Veins
Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency.
Pathogenesis of primary varicose veins.
Vascular Diseases
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis.
Effects of baicalin on collagen ? and collagen ??? expression in pulmonary arteries of rats with hypoxic pulmonary hypertension.
Effects of cyclosporine on metalloproteinase in endothelial cells.
Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans.
Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.
Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.
Vascular System Injuries
Characterization of the interactions of ADAMTS13 CUB1 domain to WT- and GOF-Spacer domain by molecular dynamics simulation.
Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease.
Serine and metalloprotease signaling through PAR1 in arterial thrombosis and vascular injury.
Transcription factor KLF6 upregulates expression of metalloprotease MMP14 and subsequent release of soluble endoglin during vascular injury.
Vasculitis
Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature.
The significance of metalloproteinase 3 (MMP-3), chemokine CXC ligand 13 (CXCL-13) and complement component C5a in different stages of ANCA associated vasculitis.
Venous Insufficiency
Inflammation in stasis dermatitis upregulates MMP-1, MMP-2 and MMP-13 expression.
Venous Thrombosis
Antithrombotic activity of Batroxase, a metalloprotease from Bothrops atrox venom, in a model of venous thrombosis.
Evaluation of the in vivo thrombolytic activity of a metalloprotease from Bothrops atrox venom using a model of venous thrombosis.
Myeloid p53 regulates macrophage polarization and venous thrombus resolution by inflammatory vascular remodeling in mice.
Vesicular Stomatitis
ZMPSTE24 Is Downstream Effector of Interferon-Induced Transmembrane Antiviral Activity.
Vibrio Infections
Microbial and histopathological study of the vibriosis caused by Vibrio vulnificus serovar E in eels: the metalloprotease Vvp is not an essential lesional factor.
Virus Diseases
A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Corticosteroids modulate Seoul virus infection, regulatory T-cell responses and matrix metalloprotease 9 expression in male, but not female, Norway rats.
Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Interferon-gamma inhibits HIV-induced invasiveness of monocytes.
Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N.
Separation and identification methods for metalloproteinase inhibitors.
Serum levels of metalloproteinases and their inhibitors during infection with pathogens having integrin receptor-mediated cellular entry.
The role of Smad1/5 in mantle immunity of the pearl oyster Pinctada fucata martensii.
Vitamin B 12 Deficiency
Atypical hemolytic uremic syndrome and complement blockade: established and emerging uses of complement inhibition.
Vitamin D Deficiency
The metalloproteinase system and vitamin D deficiency.
Vitiligo
Role of the p53?TRPM1/miR?211?MMP9 axis in UVB?induced human melanocyte migration and its potential in repigmentation.
von Hippel-Lindau Disease
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
von Willebrand Disease, Type 1
An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13.
von Willebrand Diseases
An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13.
von Willebrand factor and von Willebrand disease.
[Increased susceptibility of recombinant type 2A von Willebrand factor mutant A1500E to proteolysis by ADAMTS13].
Waldenstrom Macroglobulinemia
Matrix Metalloproteinase-8 Is Overexpressed in Waldenström's Macroglobulinemia Cells, and Specific Inhibition of this Metalloproteinase Blocks Release of Soluble CD27.
Weill-Marchesani Syndrome
ADAMTS Proteinases: Potential Therapeutic Targets?
Adamts10 inactivation in mice leads to persistence of ocular microfibrils subsequent to reduced fibrillin-2 cleavage.
The RECK tumor-suppressor protein binds and stabilizes ADAMTS10.
Werner Syndrome
Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts.
Whooping Cough
Expression and Signaling of G Protein-Coupled Estrogen Receptor (GPER) in Rat Sertoli Cells.
Phosphorylation, desensitization and internalization of human alpha1B-adrenoceptors induced by insulin-like growth factor-I.
Trimer carboxyl propeptide of collagen I produced by mature osteoblasts is chemotactic for endothelial cells.
Wilms Tumor
Suppression of tumorigenicity of rhabdoid tumor derived G401 cells by the multivalent HB-19 pseudopeptide that targets surface nucleolin.
Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development.
Wiskott-Aldrich Syndrome
Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways.
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function.
Wound Infection
Actions of Vibrio vulnificus metalloprotease on human plasma proteinase-proteinase inhibitor systems: a comparative study of native protease with its derivative modified by polyethylene glycol.
Development of an insect metalloproteinase inhibitor drug carrier system for application in chronic wound infections.
Functional domains of a zinc metalloprotease from Vibrio vulnificus.
High growing ability of Vibrio vulnificus biotype 1 is essential for production of a toxic metalloprotease causing systemic diseases in humans.
Histamine-releasing reaction induced by the N-terminal domain of Vibrio vulnificus metalloprotease.
Inhibitory effect of alpha 2-macroglobulin on Vibrio vulnificus protease.
Metalloprotease is not essential for Vibrio vulnificus virulence in mice.
The N-terminal propeptide of Vibrio vulnificus extracellular metalloprotease is both an inhibitor of and a substrate for the enzyme.