Reference on EC 3.4.24.65 - macrophage elastase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Banda, M.J.; Werb, Z.
Mouse macrophage elastase. Purification and characterization as a metalloproteinase
Biochem. J.
193
589-605
1981
Mus musculus
Kettner, C.; Shaw, E.
The specificity of macrophage elastase on the insulin B-chain
Biochem. J.
195
369-372
1981
Mus musculus
Shapiro, S.D.; Griffin, G.L.; Gilbert, D.J.; Jenkins, N.A.; Copeland, N.G.; Welgus, H.G.; Senior, R.M.; Ley, T.J.
Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase
J. Biol. Chem.
267
4664-4671
1992
Mus musculus
Shapiro, S.D.; Kobayashi, D.K.; Ley, T.J.
Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages
J. Biol. Chem.
268
23824-23829
1993
Homo sapiens
Gronski, T.J., Jr.; Martin, R.L.; Kobayashi, D.K.; Walsh, B.C.; Holman, M.C.; Huber, M.; Van Wart, H.E.; Shapiro, S.D.
Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase
J. Biol. Chem.
272
12189-12194
1997
Homo sapiens
Edelstein, C.; Shapiro, S.D.; Klezovitch, O.; Scanu, A.M.
Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology
J. Biol. Chem.
274
10019-10023
1999
Mus musculus
Lang, R.; Kocourek, A.; Braun, M.; Tschesche, H.; Huber, R.; Bode, W.; Maskos, K.
Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure
J. Mol. Biol.
312
731-742
2001
Homo sapiens (P45452), Homo sapiens
Nar, H.; Werle, K.; Bauer, M.M.; Dollinger, H.; Jung, B.
Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor
J. Mol. Biol.
312
743-751
2001
Homo sapiens
Rao, V.H.; Meehan, D.T.; Delimont, D.; Nakajima, M.; Wada, T.; Gratton, M.A.; Cosgrove, D.
Role for macrophage metalloelastase in glomerular basement membrane damage associated with alport syndrome
Am. J. Pathol.
169
32-46
2006
Mus musculus
Liu, M.; Sun, H.; Wang, X.; Koike, T.; Mishima, H.; Ikeda, K.; Watanabe, T.; Ochiai, N.; Fan, J.
Association of increased expression of macrophage elastase (matrix metalloproteinase 12) with rheumatoid arthritis
Arthritis Rheum.
50
3112-3117
2004
Homo sapiens
Houghton, A.M.; Grisolano, J.L.; Baumann, M.L.; Kobayashi, D.K.; Hautamaki, R.D.; Nehring, L.C.; Cornelius, L.A.; Shapiro, S.D.
Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases
Cancer Res.
66
6149-6155
2006
Mus musculus
Liang, J.; Liu, E.; Yu, Y.; Kitajima, S.; Koike, T.; Jin, Y.; Morimoto, M.; Hatakeyama, K.; Asada, Y.; Watanabe, T.; Sasaguri, Y.; Watanabe, S.; Fan, J.
Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits
Circulation
113
1993-2001
2006
Homo sapiens
Molet, S.; Belleguic, C.; Lena, H.; Germain, N.; Bertrand, C.P.; Shapiro, S.D.; Planquois, J.M.; Delaval, P.; Lagente, V.
Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease
Inflamm. Res.
54
31-36
2005
Homo sapiens
Bracke, K.; Cataldo, D.; Maes, T.; Gueders, M.; Noel, A.; Foidart, J.M.; Brusselle, G.; Pauwels, R.A.
Matrix metalloproteinase-12 and cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice
Int. Arch. Allergy Immunol.
138
169-179
2005
Mus musculus
Manoury, B.; Nenan, S.; Guenon, I.; Boichot, E.; Planquois, J.; Bertrand, C.P.; Lagente, V.
Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in mice
J. Inflamm.
3
2
2006
Mus musculus
Fan, J.; Wang, X.; Wu, L.; Matsumoto, S.I.; Liang, J.; Koike, T.; Ichikawa, T.; Sun, H.; Shikama, H.; Sasaguri, Y.; Watanabe, T.
Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits
Transgenic Res.
13
261-269
2004
Homo sapiens
Pender, S.L.; Li, C.K.; Sabatino, A.D.; MacDonald, T.T.; Buckley, M.G.
Role of macrophage metalloelastase in gut inflammation
Ann. N. Y. Acad. Sci.
1072
386-388
2006
Mus musculus
Churg, A.; Wang, X.; Wang, R.D.; Meixner, S.C.; Pryzdial, E.L.; Wright, J.L.
Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages
Am. J. Respir. Cell Mol. Biol.
37
144-151
2007
Mus musculus, Mus musculus C57BL/6
Chiba, Y.; Yu, Y.; Sakai, H.; Misawa, M.
Increase in the expression of matrix metalloproteinase-12 in the airways of rats with allergic bronchial asthma
Biol. Pharm. Bull.
30
318-323
2007
Rattus norvegicus
Mannino, C.; Nievo, M.; Machetti, F.; Papakyriakou, A.; Calderone, V.; Fragai, M.; Guarna, A.
Synthesis of bicyclic molecular scaffolds (BTAa): an investigation towards new selective MMP-12 inhibitors
Bioorg. Med. Chem.
14
7392-7403
2006
Homo sapiens
Shi, H.; Xu, J.M.; Hu, N.Z.; Wang, X.L.; Mei, Q.; Song, Y.L.
Transfection of mouse macrophage metalloelastase gene into murine CT-26 colon cancer cells suppresses orthotopic tumor growth, angiogenesis and vascular endothelial growth factor expression
Cancer Lett.
233
139-150
2006
Mus musculus
Nenan, S.; Lagente, V.; Planquois, J.M.; Hitier, S.; Berna, P.; Bertrand, C.P.; Boichot, E.
Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat
Eur. J. Pharmacol.
559
75-81
2007
Homo sapiens
Nenan, S.; Boichot, E.; Planquois, J.M.; Berna, P.; Hitier, S.; Benard, T.; Lagente, V.; Bertrand, C.P.
Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways
Eur. J. Pharmacol.
579
374-381
2008
Homo sapiens
Devel, L.; Rogakos, V.; David, A.; Makaritis, A.; Beau, F.; Cuniasse, P.; Yiotakis, A.; Dive, V.
Development of selective inhibitors and substrate of matrix metalloproteinase-12
J. Biol. Chem.
281
11152-11160
2006
Homo sapiens
Bhaskaran, R.; Palmier, M.O.; Bagegni, N.A.; Liang, X.; Van Doren, S.R.
Solution structure of inhibitor-free human metalloelastase (MMP-12) indicates an internal conformational adjustment
J. Mol. Biol.
374
1333-1344
2007
Homo sapiens
Taddese, S.; Weiss, A.S.; Neubert, R.H.; Schmelzer, C.E.
Mapping of macrophage elastase cleavage sites in insoluble human skin elastin
Matrix Biol.
27
420-428
2008
Homo sapiens
Zheng, X.; Ou, L.; Tong, X.; Zhu, J.; Wu, H.
Over-expression and refolding of isotopically labeled recombinant catalytic domain of human macrophage elastase (MMP-12) for NMR studies
Protein Expr. Purif.
56
160-166
2007
Homo sapiens
Uchio, K.; Sawada, K.; Manabe, N.
Expression of macrophage metalloelastase (MMP-12) in podocytes of hereditary nephrotic mice (ICGN strain)
J. Vet. Med. Sci.
71
305-312
2009
Mus musculus
Yen, C.Y.; Chen, C.H.; Chang, C.H.; Tseng, H.F.; Liu, S.Y.; Chuang, L.Y.; Wen, C.H.; Chang, H.W.
Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers
Biomarkers
14
244-249
2009
Homo sapiens
Cheng, P.; Jiang, F.H.; Zhao, L.M.; Dai, Q.; Yang, W.Y.; Zhu, L.M.; Wang, B.J.; Xu, C.; Bao, Y.J.; Zhang, Y.J.
Human macrophage metalloelastase correlates with angiogenesis and prognosis of gastric carcinoma
Digest. Dis. Sci.
55
3138-3146
2010
Homo sapiens
Boyd, S.; Virolainen, S.; Paerssinen, J.; Skoog, T.; van Hogerlinden, M.; Latonen, L.; Kylloenen, L.; Toftgard, R.; Saarialho-Kere, U.
MMP-10 (Stromelysin-2) and MMP-21 in human and murine squamous cell cancer
Exp. Dermatol.
18
1044-1052
2009
Homo sapiens
Lagente, V.; Le Quement, C.; Boichot, E.
Macrophage metalloelastase (MMP-12) as a target for inflammatory respiratory diseases
Expert Opin. Ther. Targets
13
287-295
2009
Homo sapiens, Mus musculus
Kaner, R.J.; Santiago, F.; Crystal, R.G.
Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema
J. Leukoc. Biol.
86
913-922
2009
Homo sapiens
He, J.Q.; Campagne, M.L.
Macrophage metalloelastase: stretching therapeutic opportunities
J. Mol. Cell Biol.
1
55-57
2009
Mus musculus
Houghton, A.M.; Hartzell, W.O.; Robbins, C.S.; Gomis-Rueth, F.X.; Shapiro, S.D.
Macrophage elastase kills bacteria within murine macrophages
Nature
460
637-641
2009
Mus musculus
Fulcher, Y.G.; Van Doren, S.R.
Remote exosites of the catalytic domain of matrix metalloproteinase-12 enhance elastin degradation
Biochemistry
50
9488-9499
2011
Homo sapiens
Taddese, S.; Jung, M.; Ihling, C.; Heinz, A.; Neubert, R.; Schmelzer, C.
MMP-12 catalytic domain recognizes and cleaves at multiple sites in human skin collagen type I and type III
Biochim. Biophys. Acta
1804
731-739
2010
Homo sapiens
Badland, M.; Compere, D.; Courte, K.; Dublanchet, A.C.; Blais, S.; Manage, A.; Peron, G.; Wrigglesworth, R.
Thiophene and bioisostere derivatives as new MMP12 inhibitors
Bioorg. Med. Chem. Lett.
21
528-530
2011
Homo sapiens
Liang, X.; Arunima, A.; Zhao, Y.; Bhaskaran, R.; Shende, A.; Byrne, T.S.; Fleeks, J.; Palmier, M.O.; Van Doren, S.R.
Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3
Biophys. J.
99
273-283
2010
Homo sapiens
Wei, P.C.; Tsai, C.H.; Chiu, P.S.; Lai, S.C.
Matrix metalloproteinase-12 leads to elastin degradation in BALB/c mice with eosinophilic meningitis caused by Angiostrongylus cantonensis
Int. J. Parasitol.
41
1175-1183
2011
Mus musculus
Tsuji, T.; Kelly, N.; Takahashi, S.; Leme, A.; Houghton, A.; Shapiro, S.
Macrophage elastase suppresses white adipose tissue expansion with cigarette smoking
Am. J. Respir. Cell Mol. Biol.
51
822-829
2014
Mus musculus (P34960)
Urbschat, A.; Paulus, P.; Wiegratz, I.; Beschmann, H.; Hadji, P.; Hofmann, R.; Ochsendorf, F.
Macrophage metalloelastase-12 is detectable in human seminal plasma and represents a predictor for inflammatory processes in the male genital tract
Andrologia
47
153-159
2015
Homo sapiens (P39900), Homo sapiens
Bauters, D.; Van Hul, M.; Lijnen, H.
Macrophage elastase (MMP-12) in expanding murine adipose tissue
Biochim. Biophys. Acta
1830
2954-2959
2013
Mus musculus (P34960), Mus musculus
Lavilla-Alonso, S.; Bauer, M.; Abo-Ramadan, U.; Ristimki, A.; Halavaara, J.; Desmond, R.; Wang, D.; Escutenaire, S.; Ahtiainen, L.; Saksela, K.; Tatlisumak, T.; Hemminki, A.; Pesonen, S.
Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development
Cancer Gene Ther.
19
126-134
2012
Homo sapiens
Xu, Z.; Shi, H.; Mei, Q.; Shen, Y.; Xu, J.
Effects of macrophage metalloelastase on the basic fibroblast growth factor expression and tumor angiogenesis in murine colon cancer
Digest. Dis. Sci.
57
85-91
2012
Mus musculus (P34960), Mus musculus
Lamort, A.S.; Gravier, R.; Laffitte, A.; Juliano, L.; Zani, M.L.; Moreau, T.
New insights into the substrate specificity of macrophage elastase MMP-12
Biol. Chem.
397
469-484
2016
Homo sapiens (P39900), Homo sapiens, Mus musculus (P34960), Mus musculus
Takahashi, S.; Ishii, M.; Namkoong, H.; Hegab, A.E.; Asami, T.; Yagi, K.; Sasaki, M.; Haraguchi, M.; Sato, M.; Kameyama, N.; Asakura, T.; Suzuki, S.; Tasaka, S.; Iwata, S.; Hasegawa, N.; Betsuyaku, T.
Pneumococcal infection aggravates elastase-induced emphysema via matrix metalloproteinase 12 overexpression
J. Infect. Dis.
213
1018-1030
2016
Mus musculus (P34960), Mus musculus, Mus musculus C57BL/6 (P34960)
Wagner, C.J.; Schultz, C.; Mall, M.A.
Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease
Mol. Cell. Pediatr.
3
25
2016
Mus musculus (P34960)
Kaspiris, A.; Khaldi, L.; Chronopoulos, E.; Vasiliadis, E.; Grivas, T.B.; Kouvaras, I.; Dagkas, S.; Papadimitriou, E.
Macrophage-specific metalloelastase (MMP-12) immunoexpression in the osteochondral unit in osteoarthritis correlates with BMI and disease severity
Pathophysiology
22
143-151
2015
Homo sapiens
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