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Disease on EC 3.4.24.42 - atrolysin C

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Arthritis
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.
Aggrecanase-mediated cartilage degradation.
Aggrecanase. A target for the design of inhibitors of cartilage degradation.
Association between synovial fluid levels of aggrecan ARGS fragments and radiographic progression in knee osteoarthritis.
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
Experimental arthritis: Oral aggrecanase inhibitor may slow postinjury cartilage breakdown.
Expression and regulation of aggrecanase in arthritis: the role of TGF-beta.
Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases.
Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage.
Mechanisms of proteoglycan metabolism that lead to cartilage destruction in the pathogenesis of arthritis.
Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study.
TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor.
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
Arthritis, Juvenile
Aggrecanase cleavage in juvenile idiopathic arthritis patients is minimally detected in the aggrecan interglobular domain but robust at the aggrecan C-terminus.
Arthritis, Rheumatoid
A microplate assay for the screening of ADAMTS-4 inhibitors.
Expression of a wide range of extracellular matrix molecules in the tendon and trochlea of the human superior oblique muscle.
Carcinoma
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Chondrosarcoma
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
Utilization of a recombinant substrate rAgg1 to study the biochemical properties of aggrecanase in cell culture systems.
Endometrial Neoplasms
The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer.
Infections
Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease.
Intervertebral Disc Degeneration
Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.
Region-Dependent Aggrecan Degradation Patterns in the Rat Intervertebral Disc Are Affected by Mechanical Loading In Vivo.
Intervertebral Disc Displacement
Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.
Joint Diseases
Association of serum levels of aggrecan ARGS, NITEGE fragments and radiologic knee osteoarthritis in Tunisian patients.
Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.
Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study.
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
Leukemia
Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown.
Lyme Disease
Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease.
Lyme disease spirochaetes possess an aggrecan-binding protease with aggrecanase activity.
Melanoma
Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors.
Neoplasms
"Aggrecanase" activity is implicated in tumour necrosis factor alpha mediated cartilage aggrecan breakdown but is not detected by an in vitro assay.
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.
Effect of intra-articular administration of interleukin 1 receptor antagonist on cartilage repair in temporomandibular joint.
Effect of low molecular weight heparin and different heparin molecular weight fractions on the activity of the matrix-degrading enzyme aggrecanase: structure-function relationship.
Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown.
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.
The intermediates of aggrecanase-dependent cleavage of aggrecan in rat chondrosarcoma cells treated with interleukin-1.
The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer.
Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.
Oligodendroglioma
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Osteoarthritis
10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin.
A microplate assay for the screening of ADAMTS-4 inhibitors.
A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.
Advances in the development of novel aggrecanase inhibitors.
Aggrecanase and aggrecan degradation in osteoarthritis: a review.
An aggrecanase and osteoarthritis.
Animal models of osteoarthritis: lessons learned while seeking the 'Holy Grail'.
Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation.
CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model.
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Effect of dehydroepiandrosterone on aggrecanase expression in articular cartilage in a rabbit model of osteoarthritis.
Effects of hexosamines and omega-3/omega-6 fatty acids on pH regulation by interleukin 1-treated isolated bovine articular chondrocytes.
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide.
Genetic variation including nonsynonymous polymorphisms of a major aggrecanase, ADAMTS-5, in susceptibility to osteoarthritis.
Inhibition of ADAM-TS4 and ADAM-TS5 prevents aggrecan degradation in osteoarthritic cartilage.
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Release of hyaluronan and hyaladherins (aggrecan G1 domain and link proteins) from articular cartilage exposed to ADAMTS-4 (aggrecanase 1) or ADAMTS-5 (aggrecanase 2).
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.
Osteoarthritis, Knee
The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study.
Persistent Infection
Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease.
Post-Lyme Disease Syndrome
Borrelia burgdorferi aggrecanase activity: more evidence for persistent infection in Lyme disease.
Rheumatic Diseases
A microplate assay for the screening of ADAMTS-4 inhibitors.
Spondylolisthesis
Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.
Temporomandibular Joint Disorders
Aggrecanase analysis of synovial fluid of temporomandibular joint disorders.
Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders.