Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Reference on EC 3.4.24.34 - neutrophil collagenase

Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hasty, K.A.; Jeffrey, J.J.; Hibbs, M.S.; Welgus, H.G.
The collagen substrate specificity of human neutrophil collagenase
J. Biol. Chem.
262
10048-10052
1987
Homo sapiens
Manually annotated by BRENDA team
Hasty, K.A.; Pourmotabbed, T.F.; Goldberg, G.I.; Thompson, J.P.; Spinella, D.G.; Stevens, R.M.; Mainardi, C.L.
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases
J. Biol. Chem.
265
11421-11424
1990
Homo sapiens
Manually annotated by BRENDA team
Knuper, S.; Krmer, S.; Reinke, H.; Tschesche, H.
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms
Eur. J. Biochem.
189
295-300
1990
Homo sapiens
Manually annotated by BRENDA team
Fosang, A.J.; Last, K.; Neame, P.J.; Murphy, G.; Knuper, S.; Tschesche, H.; Hughes, C.E.; Caterson, B.; Hardingham, T.E.
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan
Biochem. J.
304
347-351
1994
Homo sapiens
Manually annotated by BRENDA team
Fasciglione, G.F.; Marini, S.; D'Alessio, S.; Politi, V.; Coletta, M.
pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B
Biophys. J.
79
2138-2149
2000
Homo sapiens
Manually annotated by BRENDA team
Betz, M.; Huxley, P.; Davies, S.J.; Mushtaq, Y.; Pieper, M.; Tschesche, H.; Bode, W.; Gomis-Ruth, F.X.
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile
Eur. J. Biochem.
247
356-363
1997
Homo sapiens
Manually annotated by BRENDA team
Arner, E.C.; Decicco, C.P.; Cherney, R.; Tortorella, M.D.
Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase
J. Biol. Chem.
272
9294-9299
1997
Homo sapiens
Manually annotated by BRENDA team
Marini, S.; Fasciglione, G.F.; de Sanctis, G.; D'Alessio, S.; Politi, V.; Coletta, M.
Cleavage of bovine collagen I by neutrophil collagenase MMP-8. Effect of pH on the catalytic properties as compared to synthetic substrates
J. Biol. Chem.
275
18657-18663
2000
Homo sapiens
Manually annotated by BRENDA team
Brandstetter, H.; Grams, F.; Glitz, D.; Lang, A.; Huber, R.; Bode, W.; Krell, H.W.; Engh, R.A.
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition
J. Biol. Chem.
276
17405-17412
2001
Homo sapiens
Manually annotated by BRENDA team
Gioia, M.; Fasciglione, G.F.; Marini, S.; D'Alessio, S.; De Sanctis, G.; Diekmann, O.; Pieper, M.; Politi, V.; Tschesche, H.; Coletta, M.
Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain
J. Biol. Chem.
277
23123-23130
2002
Homo sapiens
Manually annotated by BRENDA team
Graf von Roedern, E.; Brandstetter, H.; Engh, R.A.; Bode, W.; Grams, F.; Moroder, L.
Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8)
J. Med. Chem.
41
3041-3047
1998
Homo sapiens
Manually annotated by BRENDA team
Matter, H.; Schwab, W.; Barbier, D.; Billen, G.; Haase, B.; Neises, B.; Schudok, M.; Thorwart, W.; Schreuder, H.; Brachvogel, V.; Lonze, P.; Weithmann, K.U.
Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis
J. Med. Chem.
42
1908-1920
1999
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Gavuzzo, E.; Pochetti, G.; Mazza, F.; Gallina, C.; Gorini, B.; D'Alessio, S.; Pieper, M.; Tschesche, H.; Tucker, P.A.
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design
J. Med. Chem.
43
3377-3385
2000
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Brandstetter, H.; Engh, R.A.; Von Roedern, E.G.; Moroder, L.; Huber, R.; Bode, W.; Grams, F.
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data
Protein Sci.
7
1303-1309
1998
Homo sapiens
Manually annotated by BRENDA team
Wilson, W.R.; Schwalbe, E.C.; Jones, J.L.; Bell, P.R.; Thompson, M.M.
Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm
Br. J. Surg.
92
828-833
2005
Homo sapiens
Manually annotated by BRENDA team
Khanna-Gupta, A.; Zibello, T.; Idone, V.; Sun, H.; Lekstrom-Himes, J.; Berliner, N.
Human neutrophil collagenase expression is C/EBP-dependent during myeloid development
Exp. Hematol.
33
42-52
2005
Homo sapiens
Manually annotated by BRENDA team
Fligiel, S.E.; Standiford, T.; Fligiel, H.M.; Tashkin, D.; Strieter, R.M.; Warner, R.L.; Johnson, K.J.; Varani, J.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury
Hum. Pathol.
37
422-430
2006
Homo sapiens
Manually annotated by BRENDA team
Pelman, G.R.; Morrison, C.J.; Overall, C.M.
Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3 subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond
J. Biol. Chem.
280
2370-2377
2005
Homo sapiens
Manually annotated by BRENDA team
Owen, C.A.; Hu, Z.; Lopez-Otin, C.; Shapiro, S.D.
Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase
J. Immunol.
172
7791-7803
2004
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Li, J.; Liao, E.Y.; Dai, R.C.; Wei, Q.Y.; Luo, X.H.
Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells
J. Mol. Histol.
35
723-731
2004
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Sulkala, M.; Tervahartiala, T.; Sorsa, T.; Larmas, M.; Salo, T.; Tjaederhane, L.
Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin
Arch. Oral Biol.
52
121-127
2007
Homo sapiens
Manually annotated by BRENDA team
Tuomainen, A.M.; Nyyssoenen, K.; Laukkanen, J.A.; Tervahartiala, T.; Tuomainen, T.P.; Salonen, J.T.; Sorsa, T.; Pussinen, P.J.
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men
Arterioscler. Thromb. Vasc. Biol.
27
2722-2728
2007
Homo sapiens
Manually annotated by BRENDA team
Liu, K.Z.; Hynes, A.; Man, A.; Alsagheer, A.; Singer, D.L.; Scott, D.A.
Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease
Biochim. Biophys. Acta
1762
775-780
2006
Homo sapiens
Manually annotated by BRENDA team
Korpi, J.T.; Kervinen, V.; Maeklin, H.; Vaeaenaenen, A.; Lahtinen, M.; Laeaerae, E.; Ristimaeki, A.; Thomas, G.; Ylipalosaari, M.; Astroem, P.; Lopez-Otin, C.; Sorsa, T.; Kantola, S.; Pirilae, E.; Salo, T.
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer
Br. J. Cancer
98
766-775
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wilson, W.R.; Anderton, M.; Schwalbe, E.C.; Jones, J.L.; Furness, P.N.; Bell, P.R.; Thompson, M.M.
Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture
Circulation
113
438-445
2006
Homo sapiens
Manually annotated by BRENDA team
Gutierrez-Fernandez, A.; Inada, M.; Balbin, M.; Fueyo, A.; Pitiot, A.S.; Astudillo, A.; Hirose, K.; Hirata, M.; Shapiro, S.D.; Noel, A.; Werb, Z.; Krane, S.M.; Lopez-Otin, C.; Puente, X.S.
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)
FASEB J.
21
2580-2591
2007
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Pochetti, G.; Gavuzzo, E.; Campestre, C.; Agamennone, M.; Tortorella, P.; Consalvi, V.; Gallina, C.; Hiller, O.; Tschesche, H.; Tucker, P.A.; Mazza, F.
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates
J. Med. Chem.
49
923-931
2006
Homo sapiens
Manually annotated by BRENDA team
Aschi, M.; Besker, N.; Re, N.; Pochetti, G.; Coletti, C.; Gallina, C.; Mazza, F.
Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations
J. Med. Chem.
50
211-218
2007
Homo sapiens
Manually annotated by BRENDA team
Tester, A.M.; Cox, J.H.; Connor, A.R.; Starr, A.E.; Dean, R.A.; Puente, X.S.; Lopez-Otin, C.; Overall, C.M.
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
PLoS ONE
2
e312
2007
Mus musculus
Manually annotated by BRENDA team
Marcaccini, A.M.; Novaes, A.B.; Meschiari, C.A.; Souza, S.L.; Palioto, D.B.; Sorgi, C.A.; Faccioli, L.H.; Tanus-Santos, J.E.; Gerlach, R.F.
Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy
Clin. Chim. Acta
409
117-122
2009
Homo sapiens
Manually annotated by BRENDA team
Tsai, W.C.; Hsu, C.C.; Chang, H.N.; Lin, Y.C.; Lin, M.S.; Pang, J.H.
Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells
J. Orthop. Res.
28
487-491
2010
Rattus norvegicus
Manually annotated by BRENDA team
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Manually annotated by BRENDA team
Williams, K.E.; Olsen, D.R.
Matrix metalloproteinase-1 cleavage site recognition and binding in full-length human type III collagen
Matrix Biol.
28
373-379
2009
Homo sapiens
Manually annotated by BRENDA team
Pradhan-Palikhe, P.; Vesterinen, T.; Tarkkanen, J.; Leivo, I.; Sorsa, T.; Salo, T.; Mattila, P.S.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer
Oral Oncol.
46
514-518
2010
Homo sapiens
Manually annotated by BRENDA team
Mazzini, F.; Nuti, E.; Petri, A.; Rossello, A.
Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening
J. Chromatogr. B
879
756-762
2011
Homo sapiens
Manually annotated by BRENDA team
Quintero, P.A.; Knolle, M.D.; Cala, L.F.; Zhuang, Y.; Owen, C.A.
Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice
J. Immunol.
184
1575-1588
2010
Mus musculus
Manually annotated by BRENDA team
Flynn, B.; Bhole, A.; Saeidi, N.; Liles, M.; Dimarzio, C.; Ruberti, J.
Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8)
PLoS ONE
5
e12337
2010
Homo sapiens
Manually annotated by BRENDA team
Hsieh, C.H.; Liu, C.Y.; Hsieh, Y.J.; Tai, H.C.; Wang, L.Y.; Tsai, T.H.; Chen, Y.J.
Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil
PLoS ONE
6
e21000
2011
Rattus norvegicus
Manually annotated by BRENDA team
Schubert-Unkmeir, A.; Konrad, C.; Slanina, H.; Czapek, F.; Hebling, S.; Frosch, M.
Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: A role for MMP-8
PLoS Pathog.
6
1-15
2010
Homo sapiens
Manually annotated by BRENDA team
Fang, C.; Wen, G.; Zhang, L.; Lin, L.; Moore, A.; Wu, S.; Ye, S.; Xiao, Q.
An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo
Cardiovasc. Res.
99
146-155
2013
Mus musculus (O70138), Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Thirkettle, S.; Decock, J.; Arnold, H.; Pennington, C.; Jaworski, D.; Edwards, D.
Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells
J. Biol. Chem.
288
16282-16294
2013
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Lee, E.; Han, J.; Woo, M.; Shin, J.; Park, E.; Kang, J.; Moon, P.; Baek, M.; Son, W.; Ko, Y.; Choi, J.; Kim, H.
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation
J. Immunol.
193
2384-2393
2014
Mus musculus (O70138), Mus musculus, Homo sapiens (P22894)
Manually annotated by BRENDA team
Hedenbjoerk-Lager, A.; Hamberg, K.; Paeaekkoenen, V.; Tjaederhane, L.; Ericson, D.
Collagen degradation and preservation of MMP-8 activity in human dentine matrix after demineralization
Arch. Oral Biol.
68
66-72
2016
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Daly, M.C.; Atkinson, S.J.; Varisco, B.M.; Klingbeil, L.; Hake, P.; Lahni, P.; Piraino, G.; Wu, D.; Hogan, S.P.; Zingarelli, B.; Wong, H.R.
Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion
FASEB J.
30
3453-3460
2016
Mus musculus (O70138), Mus musculus C57BL/6 (O70138)
Manually annotated by BRENDA team
Gupta, N.; Gupta, N.; Gupta, A.; Khan, S.; Bansal, N.
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
Front. Med.
9
72-76
2015
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Bian, F.; Wang, C.; Tukler-Henriksson, J.; Pflugfelder, S.C.; Camodeca, C.; Nuti, E.; Rossello, A.; Li, D.Q.; de Paiva, C.S.
MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions
J. Cell. Physiol.
231
2506-2516
2016
Mus musculus (O70138), Mus musculus, Mus musculus C57BL/6 (O70138)
Manually annotated by BRENDA team
Atkinson, S.J.; Varisco, B.M.; Sandquist, M.; Daly, M.N.; Klingbeil, L.; Kuethe, J.W.; Midura, E.F.; Harmon, K.; Opaka, A.; Lahni, P.; Piraino, G.; Hake, P.; Zingarelli, B.; Mortenson, J.E.; Wynn, J.L.; Wong, H.R.
Matrix metalloproteinase-8 augments bacterial clearance in a juvenile sepsis model
Mol. Med.
22
455-463
2016
Mus musculus (O70138), Mus musculus, Mus musculus C57BL/6 (O70138)
Manually annotated by BRENDA team
Han, J.; Lee, E.; Moon, E.; Ryu, J.; Choi, J.; Kim, H.
Matrix metalloproteinase-8 is a novel pathogenetic factor in focal cerebral ischemia
Mol. Neurobiol.
53
231-239
2016
Mus musculus (O70138)
Manually annotated by BRENDA team
Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Nat. Prod. Res.
33
1765-1768
2019
Homo sapiens (P22894)
Manually annotated by BRENDA team
McNiff, M.L.; Haynes, E.P.; Dixit, N.; Gao, F.P.; Laurence, J.S.
Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli
Protein Expr. Purif.
122
64-71
2016
Homo sapiens (P22894)
Manually annotated by BRENDA team