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Disease on EC 3.4.24.26 - pseudolysin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abscess
Suppression of polymorphonuclear leucocyte chemotaxis by Pseudomonas aeruginosa elastase in vitro: a study of the mechanisms and the correlation with ring abscess in pseudomonal keratitis.
The role of Pseudomonas aeruginosa elastase in corneal ring abscess formation in pseudomonal keratitis.
Acute Lung Injury
Acute lung injury induced by Pseudomonas aeruginosa elastase in hamsters.
Aneurysm
Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat.
Aortic Aneurysm, Abdominal
Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms. An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages.
Arthritis, Rheumatoid
A trypsin sensitive stromelysin isolated from rheumatoid synovial fluid is an activator for matrix metalloproteinases.
Paradoxical derepression of collagenase gene expression by the antirheumatic gold compound aurothiomalate.
Celiac Disease
Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease.
Cross Infection
Structural Requirements of N-alpha-Mercaptoacetyl Dipeptide (NAMdP) Inhibitors of Pseudomonas Aeruginosa Virulence Factor LasB: 3D-QSAR, Molecular Docking, and Interaction Fingerprint Studies.
Cystic Fibrosis
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Evidence that Pseudomonas aeruginosa elastase does not inactivate the bronchial inhibitor in the presence of leukocyte elastase. Studies with cystic fibrosis sputum and with pure proteins.
Functional importance of cystic fibrosis immunoglobulin G fragments generated by Pseudomonas aeruginosa elastase.
Granulocyte neutral proteases and Pseudomonas elastase as possible causes of airway damage in patients with cystic fibrosis.
Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa.
Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.
Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway.
Encephalomyelitis, Autoimmune, Experimental
Treatment of an encephalitogenic peptide from guinea pig myelin basic protein with alpha-protease and thermolysin. Isolation of fragments and determination of cleavage sites.
Hyperhomocysteinemia
Hyperhomocysteinemia induces elastolysis in minipig arteries: structural consequences, arterial site specificity and effect of captopril-hydrochlorothiazide.
Infections
Colistin stimulates the activity of neutrophil elastase and Pseudomonas aeruginosa elastase.
Diverse effects of Galleria mellonella infection with entomopathogenic and clinical strains of Pseudomonas aeruginosa.
Experimental studies of the pathogenesis of infections owing to Pseudomonas aeruginosa: elastase, an IgG protease.
Immunization with a Pseudomonas aeruginosa elastase peptide reduces severity of experimental lung infections due to P. aeruginosa Or Burkholderia cepacia.
Manipulation of the silkworm immune system by a metalloprotease from the pathogenic bacterium Pseudomonas aeruginosa.
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases.
Neutrophil elastase cleaves C3bi on opsonized pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch.
Novel Inhibitors Of The Pseudomonas aeruginosa Virulence Factor Pseudolysin/LasB: A Potential Therapeutic Approach For The Attenuation Of Virulence Mechanisms In Pseudomonal Infection.
Pseudomonas aeruginosa Keratitis: Protease IV and PASP as Corneal Virulence Mediators.
Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.
Pseudomonas protease. Purification, partial characterization, and its effect on collagen, proteoglycan, and rabbit corneas.
Keratitis
Corneal virulence of Pseudomonas aeruginosa elastase B and alkaline protease produced by Pseudomonas putida.
Identification of a novel secreted protease from Pseudomonas aeruginosa that causes corneal erosions.
Inhibition of Pseudomonas aeruginosa elastase and Pseudomonas keratitis using a thiol-based peptide.
Pseudomonas aeruginosa small protease (PASP), a keratitis virulence factor.
Specific inhibitors of Pseudomonas aeruginosa elastase as potential drugs for the treatment of Pseudomonas keratitis.
Suppression of polymorphonuclear leucocyte chemotaxis by Pseudomonas aeruginosa elastase in vitro: a study of the mechanisms and the correlation with ring abscess in pseudomonal keratitis.
The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes.
The role of Pseudomonas aeruginosa elastase in corneal ring abscess formation in pseudomonal keratitis.
Lung Neoplasms
Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells.
Neoplasms
Enhancement of neutral metalloproteinase in the dermis after one topical application of tumor-promoting phorbol ester.
Synthesis and HPLC analysis of enzymatically cleavable linker consisting of poly(ethylene glycol) and dipeptide for the development of immunoconjugate.
Osteoarthritis
The effect of drugs used in the treatment of osteoarthrosis on stromelysin (proteoglycanase) of equine synovial cell origin.
Otitis Media
[The quantitation of Pseudomonas aeruginosa elastase in suppurative chronic otitis media using a sensitive ELISA method]
Otitis Media, Suppurative
ELISA to determine immunoreactive Pseudomonas aeruginosa elastase in chronic suppurative otitis media.
[The quantitation of Pseudomonas aeruginosa elastase in suppurative chronic otitis media using a sensitive ELISA method]
Pseudomonas Infections
Pseudomonas aeruginosa elastase and its role in pseudomonas infections.
Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection.
Small Cell Lung Carcinoma
Characterization of a connective tissue degrading metalloproteinase from human small cell lung cancer cells.