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Disease on EC 3.4.24.1 - atrolysin A

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Missed
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Abortion, Spontaneous
Biological potentials for a family of disintegrin and metalloproteinase (ADAMDEC)-1 in mouse normal pregnancy.
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Acute Coronary Syndrome
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Acute Kidney Injury
MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Acute Lung Injury
Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice.
adamts13 endopeptidase deficiency
ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome.
Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura.
Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.
Adenocarcinoma
Aberrant Expression of a Disintegrin and Metalloproteinase 17/Tumor Necrosis Factor-{alpha} Converting Enzyme Increases the Malignant Potential in Human Pancreatic Ductal Adenocarcinoma.
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.
Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma.
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
PGF2?-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer.
Adenocarcinoma of Lung
Lentivirus-mediated disintegrin and metalloproteinase 17 RNA interference reversed the acquired resistance to gefitinib in lung adenocarcinoma cells in vitro.
Lysophosphatidic acid-induced ADAM12 expression mediates human adipose tissue-derived mesenchymal stem cell-stimulated tumor growth.
MicroRNA-425 promotes the development of lung adenocarcinoma via targeting A disintegrin and metalloproteinases 9 (ADAM9).
Adenomatous Polyposis Coli
Cellular Plasticity of Defa4Cre-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury.
CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers.
Alzheimer Disease
A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10.
Alpha-secretase activation--an approach to Alzheimer's disease therapy.
Alpha-secretase as a therapeutic target.
Altered cell-matrix associated ADAM proteins in Alzheimer disease.
Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome.
Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population.
Octyl Gallate Markedly Promotes Anti-Amyloidogenic Processing of APP through Estrogen Receptor-Mediated ADAM10 Activation.
Platelet a disintegrin and metallopeptidase 10 expression correlates with clock drawing test scores in Alzheimer's disease.
Sulfuretin exerts diversified functions in the processing of amyloid precursor protein.
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
The Role of the Anti-Amyloidogenic Secretase ADAM10 in Shedding the APP-Like Proteins.
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.
Variation at the ADAM10 gene locus is not associated with Creutzfeldt-Jakob disease.
Anemia, Hemolytic
Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.
Utilizing a PLASMIC score-based approach in the management of suspected immune thrombotic thrombocytopenic purpura: a cost minimization analysis within the Harvard TMA Research Collaborative.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Anemia, Macrocytic
ADAMTS-13 deficiency: can it cause chronic renal failure?
Anemia, Sickle Cell
Absence of exaggerated pharmacology by recombinant ADAMTS13 in the rat and monkey.
Aneurysm, Dissecting
A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection.
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
Antiphospholipid Syndrome
Double positivity of anti-?2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody.
Aortic Aneurysm, Abdominal
ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
Expression of a disintegrin and metalloprotease in human abdominal aortic aneurysms.
Role of ADAM9 and miR-126 in the development of abdominal aortic aneurysm.
Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice.
Vascular ADAM17 (a Disintegrin and Metalloproteinase Domain 17) Is Required for Angiotensin II/?-Aminopropionitrile-Induced Abdominal Aortic Aneurysm.
Aortic Aneurysm, Thoracic
Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model.
The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections.
Arthritis
ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation.
ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.
ADAMTS Proteinases: Potential Therapeutic Targets?
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-18: a metalloproteinase with multiple functions.
ADAMTS-4 in central nervous system pathologies.
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
ADAMTS5-mediated aggrecanolysis in murine epiphyseal chondrocyte cultures.
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Feprazone Ameliorates TNF-?-Induced Loss of Aggrecan via Inhibition of the SOX-4/ADAMTS-5 Signaling Pathway.
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption.
Inhibition of MMPs and ADAM/ADAMTS.
Interleukin-1 Induction of Aggrecanase Gene Expression in Human Articular Chondrocytes is Mediated by Mitogen-Activated Protein Kinases.
Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis.
Metalloproteases and the degradome.
Reduced incidence and severity of experimental autoimmune arthritis in mice expressing catalytically inactive A disintegrin and metalloproteinase 8 (ADAM8).
Role of Sp1 transcription factor in Interleukin-1-induced ADAMTS-4 (aggrecanase-1) gene expression in human articular chondrocytes.
TACE and other ADAM proteases as targets for drug discovery.
The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.
The nutraceutical flavonoid luteolin inhibits ADAMTS-4 and ADAMTS-5 aggrecanase activities.
The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.
Arthritis, Rheumatoid
A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis.
A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis.
A disintegrin and metalloproteinase (ADAM)-10 as a predictive factor for tocilizumab effectiveness in rheumatoid arthritis.
A disintegrin and metallproteinase 15 knockout decreases migration of fibroblast-like synoviocytes and inflammation in rheumatoid arthritis.
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.
ADAM15 adds to apoptosis resistance of synovial fibroblasts by modulating focal adhesion kinase signaling.
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
ADAMTS5 is a biomarker for prediction of response to infliximab in patients with rheumatoid arthritis.
Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.
Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.
Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes.
Involvement of a disintegrin and a metalloproteinase 8 (ADAM8) in osteoclastogenesis and pathological bone destruction.
Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes.
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.
Novel functions of inactive rhomboid proteins in immunity and disease.
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.
Asthma
A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: A meta-analysis.
A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population.
A disintegrin and metalloproteinase 33 protein in patients with asthma: Relevance to airflow limitation.
A novel peptide ADAM8 inhibitor attenuates bronchial hyperresponsiveness and Th2 cytokine mediated inflammation of murine asthmatic models.
A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia.
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
ADAM 33 gene V4 C/G rs2787094 polymorphism in psoriasis.
ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma.
ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease.
ADAM33 expression in asthmatic airways and human embryonic lungs.
ADAM33 gene polymorphisms associate with asthma susceptibility and severity in East China han population.
ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population.
ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children.
ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice.
ADAM33 polymorphisms and phenotype associations in childhood asthma.
ADAM33 polymorphisms are associated with asthma and a distinctive palm dermatoglyphic pattern.
ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population.
ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
ADAM33 protein expression and the mechanics of airway smooth muscle cells are highly correlated in ovalbumin-sensitized rats.
ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation.
ADAM8: a new therapeutic target for asthma.
Association between ADAM33 polymorphisms and adult asthma in the Japanese population.
Association between ADAM33 polymorphisms and asthma in a Thai population.
Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.
Association between ADAM33 polymorphisms and susceptibility with adult and childhood asthma among Jordanians.
Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: a meta-analysis.
Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.
Association between polymorphisms in ADAM33, CD14, and TLR4 with asthma in the Uygur population in China.
Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis.
Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations.
Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma.
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population.
Association of ADAM33 gene polymorphisms with asthma in a Chinese population.
Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia.
Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.
Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population.
Association of ADAM33 polymorphisms with childhood asthma in a northern Chinese population.
Association of matrix metalloproteinase 8 genetic polymorphisms with bronchial asthma in a Japanese population.
Asthma susceptible genes in Chinese population: a meta-analysis.
Catalytic activity of human ADAM33.
Disintegrins in health and disease.
Diversity of asthma: evolving concepts of pathophysiology and lessons from genetics.
DNA sequence variations of metalloproteinases: their role in asthma and COPD.
Downregulation of a disintegrin and metalloproteinase 33 by IFN-gamma in human airway smooth muscle cells.
Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment.
Endothelial dysfunction and pentraxin-3 in clinically stable adult asthma patients.
Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells.
Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma.
Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Frequency of genetic polymorphisms of ADAM33 and their association with allergic rhinitis among Jordanians.
Genetic aspects of the etiology and treatment of asthma.
Genetic association of ADAM33 polymorphisms with childhood asthma in Chinese Han population: A case-control study.
Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population.
Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan.
Genetics and asthma disease susceptibility in the US Latino population.
Human ADAM33: protein maturation and localization.
IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.
Increased expression of ADAM33 and ADAM8 with disease progression in asthma.
Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.
Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
Investigating the Association of ADAM33 Single Nucleotide Polymorphisms (SNPs) with Susceptibility to Allergic Asthma in Azerbaijan Population of Iran: A Case-control Study.
Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat.
Phylogenetic and molecular evolution of the ADAM (A Disintegrin And Metalloprotease) gene family from Xenopus tropicalis, to Mus musculus, Rattus norvegicus, and Homo sapiens.
Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen.
Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study.
Silencing a disintegrin and metalloproteinase?33 attenuates the proliferation of vascular smooth muscle cells via PI3K/AKT pathway: Implications in the pathogenesis of airway vascular remodeling.
Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.
T1 polymorphism in a disintegrin and metalloproteinase 33 (ADAM33) gene may contribute to the risk of childhood asthma in Asians.
TGF-?1 stimulates epithelial-mesenchymal transition mediated by ADAM33.
The ADAM33 S2 Polymorphism Is Associated with Susceptibility to Pediatric Asthma in the Chinese Han Population.
The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation.
The genetics of asthma: ADAM33 as an example of a susceptibility gene.
The Methylation Patterns of a Disintegrin and Metalloproteinase 33 Gene (ADAM33) in Adult Asthma.
The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations.
The role of the epithelium in airway remodeling in asthma.
The role of vitamin D in asthma.
The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.
Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities.
Upregulation of a disintegrin and metalloproteinase-33 by VEGF in human airway smooth muscle cells: Implications for asthma.
Upregulation of ADAM8 in the Airways of Mice with Allergic Bronchial Asthma.
[Relationship between disintegrin and metalloproteinase gene polymorphism of bronchial asthma and its severity in Uygur population].
Astrocytoma
Thromboxane A(2) receptor-mediated epidermal growth factor receptor transactivation: Involvement of PKC-delta and PKC-varepsilon in the shedding of epidermal growth factor receptor ligands.
Atherosclerosis
A disintegrin and metalloproteases: Molecular scissors in angiogenesis, inflammation and atherosclerosis.
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-18: a metalloproteinase with multiple functions.
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology.
Association Between Plasma ADAMTS-9 Levels and Severity of Coronary Artery Disease.
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism.
Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease.
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
Endothelial Cell-Derived Von Willebrand Factor, But Not Platelet-Derived, Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice.
Genetic variants rs1994016 and rs3825807 in ADAMTS7 affect its mRNA expression in atherosclerotic occlusive peripheral arterial disease.
Mechanisms in the inhibition of neointimal hyperplasia with triflavin in a rat model of balloon angioplasty.
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding.
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.
The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-? and requires Smads, p38 mitogen-activated protein kinase and c-Jun.
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
Upregulation of ADAMTS?7 and downregulation of COMP are associated with aortic aneurysm.
[Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis].
Atypical Hemolytic Uremic Syndrome
Deficiency of complement factor H-related proteins and autoantibody-positive hemolytic uremic syndrome in an infant with combined partial deficiencies and autoantibodies to complement factor H and ADAMTS13.
Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Thrombosis, Microangiopathies, and Inflammation.
Autoimmune Diseases
Novel functions of inactive rhomboid proteins in immunity and disease.
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome.
Azoospermia
ADAMTS1 and ADAMTS5 metalloproteases produced by Sertoli cells: a potential diagnostic marker in azoospermia.
Bacterial Infections
Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure.
Bone Diseases, Metabolic
Disintegrins in health and disease.
Bone Resorption
Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study.
Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to bone.
Role of alpha(v)beta(3) integrin in osteoclast migration and formation of the sealing zone.
Tablysin-15 inhibits osteoclastogenesis and LPS-induced bone loss via attenuating the integrin ?v?3 pathway.
The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice.
Border Disease
Increased expressions of ADAMTS-13, neuronal nitric oxide synthase, and neurofilament correlate with severity of neuropathology in Border disease virus-infected small ruminants.
Brain Diseases
Crosstalk between glia, extracellular matrix and neurons.
Brain Injuries
Crosstalk between glia, extracellular matrix and neurons.
Brain Injuries, Traumatic
Relative Deficiency of Plasma A Disintegrin and Metalloprotease with Thrombospondin Type 1 Repeats 13 Activity and Elevation of Human Neutrophil Peptides in Patients with Traumatic Brain Injury.
Brain Neoplasms
From putative brain tumor marker to high cognitive abilities: Emerging roles of a disintegrin and metalloprotease (ADAM) 12 in the brain.
Breast Neoplasms
A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients.
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.
ADAM28 is expressed by epithelial cells in human normal tissues And protects from C1q-induced cell death.
ADAMTS1-mediated targeting of TSP-1 by PPAR? suppresses migration and invasion of breast cancer cells.
ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma.
Antitumoral Potential of Lansbermin-I, a Novel Disintegrin from Porthidium lansbergii lansbergii Venom on Breast Cancer Cells.
Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine?disrupting chemicals.
Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom.
Connective tissue growth factor is a substrate of ADAM28.
Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression.
Endostatin and irradiation modifies the activity of ADAM10 and neprilysin in breast cancer cells.
How ADAM-9 and ADAM-11 differentially from estrogen receptor predict response to tamoxifen treatment in patients with recurrent breast cancer: a retrospective study.
Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions.
Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression.
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
MiR-126 regulated breast cancer cell invasion by targeting ADAM9.
Molecular profiling of ADAM12 in human bladder cancer.
N-glycosylation regulates ADAM8 processing and activation.
Proteinases As Biomarkers In Breast Cancer Prognosis And Diagnosis.
Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells.
Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells.
Thalidomide combined with irradiation alters the activity of two proteases.
The anticancer properties and mechanism of action of tablysin-15, the RGD-containing disintegrin, in breast cancer cells.
The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers.
Capsule Opacification
Echistatin prevents posterior capsule opacification in diabetic rabbit model via integrin linked kinase signaling pathway.
Carcinogenesis
ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis.
ADAM9 functions as a promoter of gastric cancer growth which is negatively and post-transcriptionally regulated by miR-126.
ADAMTS8 Inhibits Progression of Esophageal Squamous Cell Carcinoma.
Disintegrins from snake venoms and their applications in cancer research and therapy.
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.
Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis.
miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.
Molecular characterization and expression of a disintegrin and metalloproteinase with thrombospondin motifs 8 in chicken.
Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer.
Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis.
Transcript response of soft coral (Scleronephthya gracillimum) on exposure to polycyclic aromatic hydrocarbons.
Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer.
Carcinoma
A disintegrin and metalloproteinase 17 mRNA and protein expression in esophageal squamous cell carcinoma, as well as its clinicopathological factors and prognosis.
A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model.
A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions.
ADAM10 expression in gastric adenocarcinoma: Results of a curative gastrectomy cohort.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
ADAM28 is expressed by epithelial cells in human normal tissues And protects from C1q-induced cell death.
ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas.
ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression.
Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).
Connective tissue growth factor is a substrate of ADAM28.
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma.
Expression of "a disintegrin and metalloproteinase-33" (ADAM-33) protein in laryngeal squamous cell carcinoma.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance.
Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis.
SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas.
Src Plays a Key Role in ADAM28 Expression in v-src-Transformed Epithelial Cells and Human Carcinoma Cells.
The ADAMTS1 protease gene is required for mammary tumor growth and metastasis.
The disintegrin domain of ADAM17 antagonises fibroblast?carcinoma cell interactions.
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.
Carcinoma, Ductal
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma.
Carcinoma, Embryonal
Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.
Carcinoma, Hepatocellular
A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression.
A Disintegrin and Metalloproteinase 9 (ADAM9) in Advanced Hepatocellular Carcinoma and Their Role as a Biomarker During Hepatocellular Carcinoma Immunotherapy.
Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines.
Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells.
Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis.
microRNA-1274a, a modulator of sorafenib induced a disintegrin and metalloproteinase 9 (ADAM9) down-regulation in hepatocellular carcinoma.
miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC.
Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma.
Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy.
Polymorphisms of a Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 and Aflatoxin B1-Related Hepatocellular Carcinoma.
Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study.
Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9.
The important role of ADAM8 in the progression of hepatocellular carcinoma induced by diethylnitrosamine in mice.
Carcinoma, Non-Small-Cell Lung
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Combined RNAi targeting human Stat3 and ADAM9 as gene therapy for non-small cell lung cancer.
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
HDGF and ADAM9 are novel molecular staging biomarkers, prognostic biomarkers and predictive biomarkers for adjuvant chemotherapy in surgically resected stage I non-small cell lung cancer.
High expression of a disintegrin and metalloproteinase-9 predicts a shortened survival time in completely resected stage I non-small cell lung cancer.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
Carcinoma, Renal Cell
ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression.
Carcinoma, Squamous Cell
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues.
Cardiomegaly
A disintegrin and metalloproteinase 12 prevents heart failure by regulating cardiac hypertrophy and fibrosis.
Critical Role of ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) in Cardiac Hypertrophy Induced by Pressure Overload.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Upregulation of Nox4 Promotes Angiotensin II-Induced Epidermal Growth Factor Receptor Activation and Subsequent Cardiac Hypertrophy by Increasing ADAM17 Expression.
Cardiomyopathies
[Improvement and the mechanism of cardiac function by knockdown of ADAM10 in adriamycin-induced cardiomyopathy rats].
Cardiomyopathy, Dilated
Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy.
Inhibition of ADAM10 ameliorates doxorubicin-induced cardiac remodeling by suppressing N-cadherin cleavage.
Role of blocking ADAM10 hydrolysis site on N-cadherin by single-chain antibody in ventricular remodeling.
Cardiovascular Diseases
ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease.
Clinical and prognostic significance of serum levels of von Willebrand factor and ADAMTS-13 antigens in AL amyloidosis.
Metalloproteases and the degradome.
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Cataract
Downregulated expression of ADAM9 in anterior polar cataracts.
Cholangiocarcinoma
Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.
Comparison of ADAM19 and CUEDC2 expressions in EHCC and their clinicopathological significances.
Cholesteatoma
Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma.
Chondroma
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Chondrosarcoma
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs.
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Chronic Periodontitis
Inducible expression of A Disintegrin and Metalloproteinase 8 in chronic periodontitis and gingival epithelial cells.
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis.
[Analysis of salivary protease spectrum in chronic periodontitis].
Colitis, Ischemic
Human colonic myocytes are involved in postischemic inflammation through ADAM17-dependent TNFalpha production.
Colitis, Ulcerative
In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production.
Colonic Neoplasms
A disintegrin and metalloproteinase 8 induced epithelial-mesenchymal transition to promote the invasion of colon cancer cells via TGF-?/Smad2/3 signalling pathway.
A metalloproteinase of the disintegrin and metalloproteinases and the ThromboSpondin Motifs 6 as a novel marker for colon cancer: functional experiments.
Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression.
Overexpression of ADAM9 enhances growth factor-mediated recycling of E-cadherin in human colon cancer cell line HT29 cells.
Colorectal Neoplasms
A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of ?-Catenin, BRG1, and KDM4.
Epigenetic silencing of ADAMTS5 is associated with increased invasiveness and poor survival in patients with colorectal cancer.
Expression and Function of a Disintegrin and Metalloproteinases in Cancer-Associated Fibroblasts of Colorectal Cancer.
Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer.
Heterogeneity of metalloproteinase expression in colorectal cancer - relation of molecular findings to basic morphology.
MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28.
Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.
Communicable Diseases
A Disintegrin and Metalloproteinase-Control Elements in Infectious Diseases.
Cone-Rod Dystrophies
An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9.
Connective Tissue Diseases
Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature.
Coronary Artery Disease
ADAMTS-7 Inhibits Re-Endothelialization of Injured Arteries and Promotes Vascular Remodeling Via Cleavage of Thrombospondin-1.
ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.
Association between plasma ADAMTS-7 levels and severity of disease in patients with stable obstructive coronary artery disease.
Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease.
Protective effect of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 haplotype on coronary artery disease.
Coronary Stenosis
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
COVID-19
Alpha-1-antitrypsin: A possible host protective factor against Covid-19.
Dementia
Catalytic activity of ADAM28.
Demyelinating Diseases
Cornel Iridoid Glycoside Ameliorated Alzheimer's Disease-Like Pathologies and Necroptosis through RIPK1/MLKL Pathway in Young and Aged SAMP8 Mice.
Diabetes Mellitus
Association between Von Willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-Dimer and cystatin C levels with retinopathy in type 1 diabetes mellitus.
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Diabetes Mellitus, Type 1
Association between Von Willebrand factor, disintegrin and metalloproteinase with thrombospondin type 1 motif member 13, d-Dimer and cystatin C levels with retinopathy in type 1 diabetes mellitus.
Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Association of a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus.
Decreased IRS2 and TIMP3 expression in monocytes from offspring of type 2 diabetic patients is correlated with insulin resistance and increased intima-media thickness.
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
Diabetes, Gestational
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Diabetic Nephropathies
Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.
Diabetic Retinopathy
Metalloproteinases mediate diabetes-induced retinal neuropathy and vasculopathy.
Digestive System Neoplasms
Novel role of microRNA-126 in digestive system cancers: From bench to bedside.
Disseminated Intravascular Coagulation
Disseminated intravascular coagulation caused by moojenactivase, a procoagulant snake venom metalloprotease.
The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation.
Down Syndrome
ADAM12s as a first-trimester screening marker of trisomy.
Comparative localization of ADAMs 10 and 15 in human cerebral cortex normal aging, Alzheimer disease and Down syndrome.
Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks.
Maternal serum ADAM12s as a potential marker of trisomy 21 prior to 10 weeks of gestation.
Drug Hypersensitivity Syndrome
DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related?
Dupuytren Contracture
Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease.
Ehlers-Danlos Syndrome
ADAMTS Proteinases: Potential Therapeutic Targets?
Encephalomyelitis
ADAMTS Proteinases: Potential Therapeutic Targets?
The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine.
Encephalomyelitis, Autoimmune, Experimental
The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine.
Treatment of an encephalitogenic peptide from guinea pig myelin basic protein with alpha-protease and thermolysin. Isolation of fragments and determination of cleavage sites.
Endometrial Neoplasms
Combined therapy with disintegrin and melphalan as a new strategy in inhibition of endometrial cancer cell line (Ishikawa) growth.
Long non-coding RNA (lncRNA) HOXB-AS3 promotes cell proliferation and inhibits apoptosis by regulating ADAM9 expression through targeting miR-498-5p in endometrial carcinoma.
The investigation of serum levels of ADAMTS 5 and 8 (the A disintegrin and metalloproteinase with thrombospondin motifs) in the etiology of endometrial cancer.
Endometriosis
Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis.
Endotoxemia
Improvements in endotoxemic syndromes using a disintegrin, rhodostomin, through integrin ?v?3-dependent pathway.
Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade.
Esophageal Neoplasms
Methylation status of ADAM12 promoter are associated with its expression levels in colorectal cancer.
Esophageal Squamous Cell Carcinoma
A disintegrin and metalloproteinase 17 mRNA and protein expression in esophageal squamous cell carcinoma, as well as its clinicopathological factors and prognosis.
Expression and clinical significance of ADAM17 protein in esophageal squamous cell carcinoma.
Expression of ADAM29 and FAM135B in the pathological evolution from normal esophageal epithelium to esophageal cancer: Their differences and clinical significance.
Eye Diseases
Metalloproteinases mediate diabetes-induced retinal neuropathy and vasculopathy.
Fetal Growth Retardation
Role of ADAMTS5 in Unexplained Fetal Growth Restriction (FGR).
Fibrosarcoma
Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).
Gastroesophageal Reflux
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma.
Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease.
Gestational Trophoblastic Disease
Differential expression patterns of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) -1, -4, -5, and -14 in human placenta and gestational trophoblastic diseases.
Giant Cell Tumors
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
Gingivitis
Reduced ADAM8 levels upon non-surgical periodontal therapy in patients with chronic periodontitis.
Glioblastoma
A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells.
Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro.
Investigation of Vipera Anatolica Venom Disintegrin via Intracellular Uptake with Radiolabeling Study and Cell-Based Electrochemical Biosensing Assay.
Mass spectrometry guided venom profiling and bioactivity screening of the Anatolian Meadow Viper, Vipera anatolica.
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
MiR-145 inhibits the epithelial-to-mesenchymal transition via targeting ADAM19 in human glioblastoma.
The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.
Glioma
ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.
Anti-invasive effect of contortrostatin, a snake venom disintegrin, and TNF-alpha on malignant glioma cells.
Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member.
Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro.
Glioma-derived ADAM10 induces regulatory B cells to suppress CD8+ T cells.
Lost in disruption: Role of proteases in glioma invasion and progression.
Malpigmentation of Common Sole (Solea solea) during Metamorphosis Is Associated with Differential Synaptic-Related Gene Expression.
MicroRNA-140 represses glioma growth and metastasis by directly targeting ADAM9.
NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human ?? T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors.
Overexpression of a disintegrin and metalloprotease 8 in human gliomas is implicated in tumor progression and prognosis.
Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin.
Regulatory effect of nerve growth factor in alpha9beta1 integrin-dependent progression of glioblastoma.
Regulatory effect of nerve growth factor in {alpha}9{beta}1 integrin-dependent progression of glioblastoma.
Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.
The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model.
Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.
Head and Neck Neoplasms
A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion.
Heart Arrest
Thrombotic Thrombocytopenic Purpura: Revisiting a Miss and an Inevitable Consequence.
Heart Diseases
Cardiac remodeling and failure From molecules to man (Part II).
Elevated expression of the metalloproteinase ADAM8 associates with vascular diseases in mice and humans.
Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease.
Interrelation between Expression of ADAM 10 and MMP 9 and Synthesis of Peroxynitrite in Doxorubicin Induced Cardiomyopathy.
Heart Failure
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding.
Heart Septal Defects, Ventricular
Essential role for ADAM19 in cardiovascular morphogenesis.
Hemolytic-Uremic Syndrome
Acute kidney injury in Hemiscorpius lepturus scorpion stung children: Risk factors and clinical features.
Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis.
Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
[Thrombotic microangiopathy].
Hemophilia B
Development of novel treatment options for patients with haemophilia.
Hepatitis B, Chronic
Plasma Level of ADAMTS13 or IL-12 as an Indicator of HBeAg Seroconversion in Chronic Hepatitis B Patients Undergoing m-ETV Treatment.
Hepatitis C
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Hepatitis C, Chronic
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Herpes Simplex
Contortrostatin, a homodimeric disintegrin isolated from snake venom inhibits herpes simplex virus entry and cell fusion.
Herpes Zoster
GPI-Anchored Protein Complex, LY6K/TEX101, Is Required for Sperm Migration into the Oviduct and Male Fertility in Mice.
Importance of the Porcine ADAM3 Disintegrin Domain in Sperm-Egg Interaction.
Mouse sperm-egg plasma membrane interactions: analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) beta.
Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male infertility.
Hodgkin Disease
Inhibitors of A Disintegrin And Metalloproteinases-10 reduce Hodgkin lymphoma cell growth in 3D microenvironments and enhance brentuximab-vedotin effect.
Huntington Disease
ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Hydatidiform Mole
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Hyperalgesia
Inhibition of neuropathic pain by a potent disintegrin--triflavin.
Hyperemia
Leptin induces ovulation in GnRH-deficient mice.
Hyperlipidemias
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Cholesterol diet-induced hyperlipidemia influences gene expression pattern of rat hearts: a DNA microarray study.
Hypersensitivity
ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation.
Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy.
Hypertension
?-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17.
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
Insights into the activity, differential expression, mutual regulation, and functions of matrix metalloproteinases and a disintegrin and metalloproteinases in hypertension and cardiac disease.
Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.
Matrix metalloproteinase-7 and ADAM-12 (a disintegrin and metalloproteinase-12) define a signaling axis in agonist-induced hypertension and cardiac hypertrophy.
Hypertension, Malignant
Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy.
Hypertension, Portal
ADAMTS13 deficiency, despite well-compensated liver functions in patients with noncirrhotic portal hypertension.
Altered von Willebrand Factor and ADAMTS13 Levels in Children With Cirrhosis and Extrahepatic Portal Hypertension.
Hypoglossal Nerve Injuries
A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons.
Hypogonadism
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Immune System Diseases
ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice.
Infarction, Middle Cerebral Artery
Crotalus atrox disintegrin reduces hemorrhagic transformation by attenuating matrix metalloproteinase-9 activity after middle cerebral artery occlusion in hyperglycemic male rats.
Evaluation of the disintegrin, triflavin, in a rat middle cerebral artery thrombosis model.
Infections
ADAM15 Participates in Tick-Borne Encephalitis Virus Replication.
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Cronobacter sakazakii Infection in Early Postnatal Rats Impaired Contextual-Associated Learning: a Putative Role of C5a-Mediated NF-?? and ASK1 Pathways.
Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus ?-toxin action.
Expression levels of A disintegrin and metalloproteases (ADAMs), and Th17-related cytokines and their association with Helicobacter pylori infection in patients with gastroduodenal diseases.
How Helicobacter pylori infection controls gastric acid secretion.
von Willebrand factor increases in experimental cerebral malaria but is not essential for late-stage pathogenesis in mice.
Inflammatory Bowel Diseases
High Expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a Sheddase for TNF-? in the Mucosa of Patients with Inflammatory Bowel Diseases.
Infliximab restores the dysfunctional matrix remodeling protein and growth factor gene expression in patients with inflammatory bowel disease.
Molecular design and structural optimization of potent peptide hydroxamate inhibitors to selectively target human ADAM metallopeptidase domain 17.
Influenza, Human
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Insulin Resistance
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Intervertebral Disc Degeneration
Resistin Promotes Intervertebral Disc Degeneration by Up-Regulation of ADAMTS-5 Through p38 MAPK Signaling Pathway.
[Electroacupuncture down-regulates expression of ADAMTS-4 of intervertebral disc in rats with lumbar intervertebral disc degeneration].
[Expression of p16INK4a in nucleus pulposus and its effect on degenerated intervertebral discs].
Intestinal Volvulus
Human colonic myocytes are involved in postischemic inflammation through ADAM17-dependent TNFalpha production.
Iron Overload
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Ischemic Stroke
ADAMTS-13 Activity Predicts Outcome in Acute Ischaemic Stroke Patients Undergoing Endovascular Treatment.
Association between ADAM17 Promoter Polymorphisms and Ischemic Stroke in a Chinese Population.
Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events.
The Value of ADAMTS13 in Predicting Clinical Outcomes in Patients With Acute Ischemic Stroke Receiving Thrombolysis.
[Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis].
Joint Diseases
Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.
Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors.
Nesfatin-1 suppresses interleukin-1?-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats.
Novel functions of inactive rhomboid proteins in immunity and disease.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Kidney Diseases
ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury.
Kidney Failure, Chronic
Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients.
Leukemia
Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.
Integrin VLA-5 and FAK are Good Targets to Improve Treatment Response in the Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Leukemia, Hairy Cell
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Liver Cirrhosis
ADAMTS13 Levels in Young Patients With ?-Thalassemia Major: Relation to Hepatitis C Virus Infection, Liver Cirrhosis, and Iron Overload.
Increased ADAMTS-13 proteolytic activity in rat hepatic stellate cells upon activation in vitro and in vivo.
Liver Diseases
Hepatic expression of A disintegrin and metalloproteinase (ADAM) and ADAMs with thrombospondin motives (ADAM-TS) enzymes in patients with chronic liver diseases.
Targeting von Willebrand factor in liver diseases: A novel therapeutic strategy?
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Liver Neoplasms
Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.
MicroRNA-145 inhibits cell proliferation by directly targeting ADAM17 in hepatocellular carcinoma.
Transcriptome analysis of PPAR? target genes reveals the involvement of lysyl oxidase in human placental cytotrophoblast invasion.
Lung Diseases
Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis.
Polymorphisms of the ADAM33 gene and Chronic Obstructive Pulmonary Disease Risk: a Meta-Analysis.
Lung Neoplasms
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.
Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS-13 in patients with lung cancer.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Combined RNAi targeting human Stat3 and ADAM9 as gene therapy for non-small cell lung cancer.
Differential expressions of matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs and their endogenous inhibitors among histologic subtypes of lung cancers.
Differential Expressions Of Matrix Metalloproteinases, A Disintegrin And Metalloproteinases, And A Disintegrin And Metalloproteinases With Thrombospondin Motifs And Their Endogenous Inhibitors Among Histologic Subtypes Of Lung Cancers.
Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
HDGF and ADAM9 are novel molecular staging biomarkers, prognostic biomarkers and predictive biomarkers for adjuvant chemotherapy in surgically resected stage I non-small cell lung cancer.
High expression of a disintegrin and metalloproteinase-9 predicts a shortened survival time in completely resected stage I non-small cell lung cancer.
Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor associated dendritic cells by expressing HB-EGF.
Protective effects of ADAM8 against cisplatin-mediated apoptosis in non-small-cell lung cancer.
RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
Saxatilin suppresses tumor-induced angiogenesis by regulating VEGF expression in NCI-H460 human lung cancer cells.
The disintegrin tzabcanin inhibits adhesion and migration in melanoma and lung cancer cells.
The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
Lupus Nephritis
Novel functions of inactive rhomboid proteins in immunity and disease.
Lymphatic Metastasis
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Lymphoma
Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies.
Lymphoma, B-Cell
Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Hydrostatic Pressure Regulates Oxidative Stress through microRNA in Human Osteoarthritic Chondrocytes.
Malaria
Effect of metalloprotease inhibitors on invasion of red blood cell by Plasmodium falciparum.
Malaria, Cerebral
Association of ADAMTS13 polymorphism with cerebral malaria.
Medulloblastoma
Prognostic and clinical implication of a disintegrin and metalloprotease 8 expression in pediatric medulloblastoma.
Melanoma
A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis.
ADAM10 Is Upregulated in Melanoma Metastasis Compared with Primary Melanoma.
Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth.
Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).
Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors.
Biological Properties of Melanoma and Endothelial Cells after Plasmid AMEP Gene Electrotransfer Depend on Integrin Quantity on Cells.
Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis.
Disintegrin tablysin-15 suppresses cancer hallmarks in melanoma cells by blocking FAK/Akt/ERK and NF-?B signaling.
Echistatin induces decrease of pp125FAK phosphorylation, disassembly of actin cytoskeleton and focal adhesions, and detachment of fibronectin-adherent melanoma cells.
Effect of the disintegrin eristostatin on melanoma-natural killer cell interactions.
Identification of binding peptides of the ADAM15 disintegrin domain using phage display.
Inhibition of melanoma cell motility by the snake venom disintegrin eristostatin.
Inhibition of melanoma cells tumorigenicity by the snake venom toxin jararhagin.
Inhibitory effect of salmosin, a Korean snake venom-derived disintegrin, on the integrin alphav-mediated proliferation of SK-Mel-2 human melanoma cells.
Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells.
Metalloproteinases in melanoma.
New insights on disintegrin-receptor interactions: eristostatin and melanoma cells.
Recombinant rubistatin (r-Rub), an MVD disintegrin, inhibits cell migration and proliferation, and is a strong apoptotic inducer of the human melanoma cell line SK-Mel-28.
Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells.
Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3.
Screening cellular proteins involved in the anti-proliferative effect of the ADAM15 disintegrin domain in murine melanoma cells.
The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells.
The disintegrin tzabcanin inhibits adhesion and migration in melanoma and lung cancer cells.
UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines.
Melanoma, Experimental
Antitumoral and antimetastatic effect of antiangiogenic plasmids in B16 melanoma: Higher efficiency of the recombinant disintegrin domain of ADAM 15.
Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis.
Metabolic Syndrome
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 18 Deficiency Leads to Visceral Adiposity and Associated Metabolic Syndrome in Mice.
ADAM19: A Novel Target for Metabolic Syndrome in Humans and Mice.
Mouth Neoplasms
A disintegrin and metalloproteinase domain 17-epidermal growth factor receptor signaling contributes to oral cancer pain.
Involvement of the A disintegrin and metalloproteinase 9 in oral cancer cell invasion.
Multiple Myeloma
Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.
Multiple Sclerosis
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Muscular Dystrophies
Animal models for muscular dystrophy; mechanism of disease and potential therapy.
Muscular Dystrophy, Duchenne
Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins.
Myocardial Infarction
Effect of Acute Myocardial Infarction on a Disintegrin and Metalloprotease with Thrombospondin Motif 13 and Von Willebrand Factor and Their Relationship with Markers of Inflammation.
Effects of metoprolol treatment on a disintegrin metalloproteinase expression and extracellular matrix remodeling after myocardial infarction in rats.
Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack.
Expression of ADAM-15 in rat myocardial infarction.
Molecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow.
Myocardial infarction induces early increased remote ADAM8 expression of rat hearts after cardiac arrest.
Syzygium Polyanthum Reduced TNF-? and ADAM17 Protein Expression in Myocardial Infarction Rat Model.
The continuing saga of snake venom disintegrins.
The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study.
The role of von Willebrand factor and ADAMTS13 in the no-reflow phenomenon: after primary percutaneous coronary intervention.
nadph dehydrogenase deficiency
Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.
Nasal Polyps
A disintegrin and metalloprotease 10-containing exosomes derived from nasal polyps promote angiogenesis and vascular permeability.
Expression of a disintegrin and metalloproteinase 8 by inflammatory cells in nasal polyps.
Neoplasm Metastasis
A novel alpha(v)beta (3)-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis.
Aberrant expression of disintegrin-metalloprotease proteins in the formation and progression of uterine cervical cancer.
Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.
ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)-Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma.
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
ADAM9 enhances CDCP1 by inhibiting miR-1 through EGFR signaling activation in lung cancer metastasis.
ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT.
ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis.
Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris.
Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis.
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Epigenetic inactivation of the extracellular matrix metallopeptidase ADAMTS19 gene and the metastatic spread in colorectal cancer.
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Expression of ADAM-9 mRNA and protein in human breast cancer.
Expression of ADAM15 in lung carcinomas.
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells.
Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis.
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Inhibition of ADAMTS1 Expression by Lentiviral CRISPR/Cas9 Gene Editing Technology.
Integrin alphavbeta3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line.
Metalloproteinase-dependent and -independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs-15.
Methods for Evaluation of a Snake Venom-Derived Disintegrin in Animal Models of Human Cancer.
MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma.
miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.
Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture.
N-glycosylation regulates ADAM8 processing and activation.
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
Overexpression of a disintegrin and metalloproteinase 21 is associated with motility, metastasis, and poor prognosis in hepatocellular carcinoma.
RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis.
SOX4, an epithelial-mesenchymal transition inducer, transactivates ADAM28 gene expression and co-localizes with ADAM28 at the invasive front of human breast and lung carcinomas.
Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis.
Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis.
Thalidomide combined with irradiation alters the activity of two proteases.
The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone.
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression.
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form.
Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
Neoplasms
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis.
A disintegrin and metalloprotease (ADAM)10 is highly expressed in hepatocellular carcinoma and is associated with tumour progression.
A Disintegrin and Metalloprotease 15 is Expressed on Rheumatoid Arthritis Synovial Tissue Endothelial Cells and may Mediate Angiogenesis.
A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury.
A disintegrin and metalloprotease 23 hypermethylation predicts decreased disease-free survival in low-risk breast cancer patients.
A disintegrin and metalloproteinase 9 is involved in ectodomain shedding of receptor-binding cancer antigen expressed on SiSo cells.
A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling.
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹?F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging.
A novel disintegrin salmosin inhibits tumor angiogenesis.
A Novel TNF-? Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice.
A preliminary study: is fibulin 1 a friend or an enemy that needs to be silenced with siRNAs for mesothelioma?
A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
A substrate-optimized electrophoretic mobility shift assay for ADAM12.
A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17.
Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers.
Aberrant expression of disintegrin-metalloprotease proteins in the formation and progression of uterine cervical cancer.
Activation of epidermal growth factor receptor signaling by the prostaglandin E(2) receptor EP4 pathway during gastric tumorigenesis.
ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with ?v?6 integrin.
ADAM-10 and ADAM-17 in the inflamed human CNS.
ADAM-12 as a Diagnostic Marker for the Proliferation, Migration and Invasion in Patients with Small Cell Lung Cancer.
ADAM10 as a therapeutic target for cancer and inflammation.
ADAM10 correlates with uveal melanoma metastasis and promotes in vitro invasion.
ADAM10 Is a Potential Novel Prognostic Biomarker for Sacral Chordoma.
ADAM10 is overexpressed in human hepatocellular carcinoma and contributes to the proliferation, invasion and migration of HepG2 cells.
ADAM10 mediates malignant pleural mesothelioma invasiveness.
ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing.
ADAM12 and ADAM17 Gene Expression in Laser-capture Microdissected and Non-microdissected Breast Tumors.
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.
ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis, and increased tumor growth.
ADAM12-cleaved ephrin-A1 contributes to lung metastasis.
ADAM15 deficiency attenuates pulmonary hyperpermeability and acute lung injury in lipopolysaccharide-treated mice.
ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease.
ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction.
ADAM17 as a therapeutic target in multiple diseases.
ADAM17 at the interface between inflammation and autoimmunity.
ADAM17 but not ADAM10 mediates tumor necrosis factor-alpha and L-selectin shedding from leukocyte membranes.
ADAM17 mediates MMP9 expression in lung epithelial cells.
ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).
Adam17, a Target of Mir-326, Promotes Emt-Induced Cells Invasion in Lung Adenocarcinoma.
ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma.
ADAM17_i33708A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the Genetics of Lipid Lowering Drugs and Diet Network study.
ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK - AKT Signaling.
ADAM28 is a serological and histochemical marker for non-small-cell lung cancers.
ADAM8 expression in prostate cancer is associated with parameters of unfavorable prognosis.
ADAM8 substrate specificity: Influence of pH on pre-processing and proteoglycan degradation.
ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.
ADAM9 decreases in castration resistant prostate cancer and is a prognostic factor for overall survival.
ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer.
ADAM9 Expression Is Associate with Glioma Tumor Grade and Histological Type, and Acts as a Prognostic Factor in Lower-Grade Gliomas.
ADAM9 expression promotes an aggressive lung adenocarcinoma phenotype.
ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression.
ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-?B Pathway.
ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells.
ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.
ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-18: a metalloproteinase with multiple functions.
ADAMTS1 is regulated by interleukin-1beta, not by hypoxia, in chondrosarcoma.
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse.
ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4.
ADAMTS19 Suppresses Cell Migration and Invasion by Targeting S100A16 via the NF-?B Pathway in Human Gastric Cancer.
ADAMTS6 suppresses tumor progression via the ERK signaling pathway and serves as a prognostic marker in human breast cancer.
ADAMTS8 Inhibits Cell Proliferation and Invasion, and Induces Apoptosis in Breast Cancer.
ADAMTS8 Inhibits Progression of Esophageal Squamous Cell Carcinoma.
ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma.
Adipose tissue inflammation and liver fat in patients with highly active antiretroviral therapy-associated lipodystrophy.
Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats.
Allogenic Pure Platelet-Rich Plasma Therapy for Adhesive Capsulitis: A Bed-to-Bench Study With Propensity Score Matching Using a Corticosteroid Control Group.
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.
An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention.
Analysis of ADAM9 regulation and function in vestibular schwannoma primary cells.
Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in experimental melanoma growth.
Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines.
Anti-invasive and anti-adhesive activities of a recombinant disintegrin, r-viridistatin 2, derived from the Prairie rattlesnake (Crotalus viridis viridis).
Antiplatelet and anti-proliferative action of disintegrin from Echis multisquamatis snake venom.
Antitumor and anti-angiogenic activity of the recombinant human disintegrin domain of A disintegrin and metalloproteinase 15.
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Asthma susceptible genes in Chinese population: a meta-analysis.
BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.
Baseline and decline of serum ADAM28 during chemotherapy of advanced non-small cell lung cancer: a probable predictive and prognostic factor.
Bone morphogenetic protein-7 antagonizes tumor necrosis factor-?-induced activation of nuclear factor ?B and up-regulation of the ADAMTS, leading to decreased degradation of disc matrix macromolecules aggrecan and collagen II.
Breast cancer is associated with methylation and expression of the a disintegrin and metalloproteinase domain 33 (ADAM33) gene affected by endocrine?disrupting chemicals.
Catalytic properties of ADAM12 and its domain deletion mutants.
Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-? in hepatocytes requires activation of Src and the NADPH oxidase NOX1.
Cell adhesion-induced transient interaction of ADAM15 with poly(A) binding protein at the cell membrane colocalizes with mRNA translation.
Cell-surface Metalloprotease ADAM12 is Internalized by a Clathrin- and Grb2-dependent Mechanism.
Central and peripheral region tibial plateau chondrocytes respond differently to in vitro dynamic compression.
Characterization of matrix metalloproteinase-2 and -9, ADAM-10 and N-cadherin expression in human glioblastoma multiforme.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays.
Circadian Expression of TIMP3 Is Disrupted by UVB Irradiation and Recovered by Green Tea Extracts.
Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients.
Clinical significance of ADAM10 expression in laryngeal carcinoma.
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
Combined therapy with disintegrin and melphalan as a new strategy in inhibition of endometrial cancer cell line (Ishikawa) growth.
Constitutive endocytosis of the chemokine, CX3CL1, prevents its degradation by cell surface metalloproteases.
Contortrostatin, a homodimeric disintegrin, actively disrupts focal adhesion and cytoskeletal structure and inhibits cell motility through a novel mechanism.
Contortrostatin, a snake venom disintegrin, induces alphavbeta3-mediated tyrosine phosphorylation of CAS and FAK in tumor cells.
Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2.
Control of ADAM17 activity by regulation of its cellular localisation.
Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris.
Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs.
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients.
Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.
Delineating the molecular basis of the inactivity of tissue inhibitor of metalloproteinase-2 against tumor necrosis factor-alpha-converting enzyme.
Dendritic cells from aged subjects contribute to chronic airway inflammation by activating bronchial epithelial cells under steady state.
Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent.
Differential regulation of tyrosine phosphorylation in tumor cells by contortrostatin, a homodimeric disintegrin, and monomeric disintegrins echistatin and flavoridin.
Disintegrin tablysin-15 suppresses cancer hallmarks in melanoma cells by blocking FAK/Akt/ERK and NF-?B signaling.
Disintegrins from snake venoms and their applications in cancer research and therapy.
Disintegrins in health and disease.
Disintegrins.
Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.
DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells.
Downregulation of ADAMTS18 May Serve as a Poor Prognostic Biomarker for Cervical Cancer Patients.
Dynamic induction of ADAMTS1 gene in the early phase of acute myocardial infarction.
Effect of ADAM28 on carcinoma cell metastasis by cleavage of von Willebrand factor.
Effect of tetramethylpyrazine combined with cisplatin on VEGF, KLF4 and ADAMTS1 in Lewis lung cancer mice.
Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and tumor metastasis in vivo.
Effects of ADAM10 and ADAM17 Inhibitors on Natural Killer Cell Expansion and Antibody-dependent Cellular Cytotoxicity Against Breast Cancer Cells
Effects of biological drug adalimumab on tumour necrosis factor-alpha-converting enzyme activation.
Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis.
EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.
Epigenetic regulation by Z-DNA silencer function controls cancer-associated ADAM-12 expression in breast cancer: cross-talk between MeCP2 and NF1 transcription factor family.
Epigenetic Regulation of a Disintegrin and Metalloproteinase (ADAM) Transcription in Colorectal Cancer Cells: Involvement of ?-Catenin, BRG1, and KDM4.
Expression and Function of a Disintegrin and Metalloproteinases in Cancer-Associated Fibroblasts of Colorectal Cancer.
Expression and function of tumour necrosis factor-alpha-converting enzyme in the central nervous system.
Expression and inhibition of ADAMDEC1 in craniopharyngioma cells.
Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis.
Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer.
Expression of ADAM-9 mRNA and protein in human breast cancer.
Expression of ADAM15 in lung carcinomas.
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.
Expression of ADAMTS4 in Ewing's sarcoma.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Expression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis.
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding.
Factor XII blockade inhibits aortic dilatation in angiotensin II-infused apolipoprotein E-deficient mice.
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin.
Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome.
Ghrelin protects against nucleus pulposus degeneration through inhibition of NF-?B signaling pathway and activation of Akt signaling pathway.
Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.
Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-?B signaling pathway in vivo and in vitro.
Helping Eve overcome ADAM: G-quadruplexes in the ADAM-15 promoter as new molecular targets for breast cancer therapeutics.
Hierarchy of ADAM12 binding to integrins in tumor cells.
High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer.
High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells.
High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.
Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
Human colonic myocytes are involved in postischemic inflammation through ADAM17-dependent TNFalpha production.
Hypoxia-derived exosomes induce putative altered pathways in biosynthesis and ion regulatory channels in glioblastoma cells.
Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model.
Identification of SH3 domain proteins interacting with the cytoplasmic tail of the a disintegrin and metalloprotease 10 (ADAM10).
IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage.
IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-? Through the JAK-STAT Signaling Pathway.
Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes.
Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.
Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis.
In silico characterization of the interaction between LSKL peptide, a LAP-TGF-beta derived peptide, and ADAMTS1.
In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production.
In Vitro Anti-Inflammation and Chondrogenic Differentiation Effects of Inclusion Nanocomplexes of Hyaluronic Acid-Beta Cyclodextrin and Simvastatin.
In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.
Increased Expression of a Disintegrin and Metalloprotease-9 in Hepatocellular Carcinoma: Implications for Tumor Progression and Prognosis.
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer.
Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.
Influence of an n-3 long-chain polyunsaturated fatty acid-enriched diet on experimentally induced synovitis in horses.
Inhibiting adenoid cystic carcinoma cells growth and metastasis by blocking the expression of ADAM 10 using RNA interference.
Inhibition of ?v?3 integrin induces loss of cell directionality of oral squamous carcinoma cells (OSCC).
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Inhibition of ADAMTS1 Expression by Lentiviral CRISPR/Cas9 Gene Editing Technology.
Inhibition of angiogenesis and tumor progression by hydrodynamic cotransfection of angiostatin K1-3, endostatin, and saxatilin genes.
Inhibition of lung tumor colonization and cell migration with the disintegrin crotatroxin 2 isolated from the venom of Crotalus atrox.
Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions.
Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain.
Inhibition of tumor formation by snake venom disintegrin.
Inhibitory effect of the salmosin gene transferred by cationic liposomes on the progression of B16BL6 tumors.
Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin alpha 9beta 1 with VCAM-1, tenascin-C, and osteopontin.
Inhibitory effects of salmosin, a disintegrin, on posterior capsular opacification in vitro and in vivo.
iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway.
Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.
Integrin alphavbeta3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line.
Integrins in the ovary.
Interactions between tumour cells and stromal cells and proteolytic modification of the extracellular matrix by metalloproteinases in cancer.
Interferon-gamma down-regulates expression of tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats.
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytes.
Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.
iRhom2: An Emerging Adaptor Regulating Immunity and Disease.
Joint Entropy-Assisted Graphene Oxide-Based Multiplexing Biosensing Platform for Simultaneous Detection of Multiple Proteases.
Knockout of ADAM10 enhances sorafenib antitumor activity of hepatocellular carcinoma in vitro and in vivo.
Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth.
Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells.
Low levels of ADAM23 expression in epithelial ovarian cancer are associated with poor survival.
Matrix metalloproteinases and TACE play a role in the pathogenesis of endometriosis.
Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma.
Membrane-anchored CD40 is processed by the tumor necrosis factor-alpha-converting enzyme. Implications for CD40 signaling.
Metalloprotease-disintegrin ADAM 12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells.
Metalloprotease-mediated tumor cell shedding of B7-H6, the ligand of the natural killer cell-activating receptor NKp30.
Metalloproteases and the degradome.
Metalloproteinases and the modulation of GH signaling.
Metalloproteinases and their inhibitors in tumor angiogenesis.
Methods for Evaluation of a Snake Venom-Derived Disintegrin in Animal Models of Human Cancer.
MicroRNA-21-5p are involved in apoptosis and invasion of fibroblast-like synoviocytes through PTEN/PI3K/AKT signal.
miR-126 inhibits cell growth, invasion, and migration of osteosarcoma cells by downregulating ADAM-9.
Modeling of enzyme-substrate complexes for the metalloproteases MMP-3, ADAM-9 and ADAM-10.
Modulation of the microenvironment and adhesion of cancer cells by ADAMs (a disintegrin and metalloproteinase).
Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region.
Molecular Pathways: Receptor Ectodomain Shedding in Treatment, Resistance, and Monitoring of Cancer.
MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.
Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells.
Multimeric disintegrin protein polymer fusions that target tumor vasculature.
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
N-glycosylation regulates ADAM8 processing and activation.
Neutralization of ADAM8 ameliorates liver injury and accelerates liver repair in carbon tetrachloride-induced acute liver injury.
Novel role of microRNA-126 in digestive system cancers: From bench to bedside.
Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway.
Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
Opposite Roles of CCR2 and CX3CR1 Macrophages in Alkali-Induced Corneal Neovascularization.
Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer.
Overexpression of a disintegrin and metalloprotease 8 in human gliomas is implicated in tumor progression and prognosis.
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma.
Overexpression of ADAM10 in oral squamous cell carcinoma with metastases.
Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis.
Overexpression of ADAM9 in oral squamous cell carcinoma.
Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers.
Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.
Phylogenetic and molecular evolution of the ADAM (A Disintegrin And Metalloprotease) gene family from Xenopus tropicalis, to Mus musculus, Rattus norvegicus, and Homo sapiens.
Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors.
Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells.
Porphyromonas gingivalis stimulates TACE production by T cells.
Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin.
Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Potentiation of radiotherapy by a localized antiangiogenic gene therapy.
Pro-tumor necrosis factor-alpha processing activity is tightly controlled by a component that does not affect notch processing.
Processing of tumor necrosis factor by the membrane-bound TNF-alpha-converting enzyme, but not its truncated soluble form.
Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis.
Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer.
Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells.
Protein processing mechanisms: from angiotensin-converting enzyme to Alzheimer's disease.
Protein-tyrosine Pseudokinase 7 (PTK7) Directs Cancer Cell Motility and Metastasis.
Rebamipide reduces amyloid-? 1-42 (A?42) production and ameliorates A?43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells.
Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells.
Recombinant disintegrin domain of human ADAM9 inhibits migration and invasion of DU145 prostate tumor cells.
Regulation of the inflammatory cycle by a controllable release hydrogel for eliminating postoperative inflammation after discectomy.
Regulatory effect of nerve growth factor in alpha9beta1 integrin-dependent progression of glioblastoma.
Regulatory effect of nerve growth factor in {alpha}9{beta}1 integrin-dependent progression of glioblastoma.
Relationship Between ADAMTS8, ADAMTS18, and ADAMTS20 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) Expressions and Tumor Molecular Classification, Clinical Pathological Parameters, and Prognosis in Breast Invasive Ductal Carcinoma.
Relationships between early inflammatory response to bleomycin and sensitivity to lung fibrosis: a role for dipeptidyl-peptidase I and tissue inhibitor of metalloproteinase-3?
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction.
Rhodocetin antagonizes stromal tumor invasion in vitro and other alpha2beta1 integrin-mediated cell functions.
Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells.
RNAi-mediated A disintegrin and metalloproteinase 9 gene silencing inhibits the tumor growth of non-small lung cancer in vitro and in vivo.
RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail.
Saxatilin inhibits TNF-alpha-induced proliferation by suppressing AP-1-dependent IL-8 expression in the ovarian cancer cell line MDAH 2774.
Saxatilin, a snake venom disintegrin, suppresses TNF-alpha-induced ovarian cancer cell invasion.
Scutellarin Attenuates the IL-1?-Induced Inflammation in Mouse Chondrocytes and Prevents Osteoarthritic Progression.
Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
Selective inhibition of ADAM28 suppresses lung carcinoma cell growth and metastasis.
Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment.
Shedding of endogenous MHC class I-related chain molecules A and B (MICA and MICB) from different human tumor entities: Heterogeneous involvement of the a disintegrin and metalloproteases 10 and 17 (ADAM10 and ADAM17).
Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF?7 cells in vitro and in vivo and its mechanism of action.
SRC fine-tunes ADAM10 shedding activity to promote pituitary adenoma cell progression.
Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.
Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function.
Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity.
Suppressive mechanism of salmosin, a novel disintegrin in B16 melanoma cell metastasis.
Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis.
Syzygium Polyanthum Reduced TNF-? and ADAM17 Protein Expression in Myocardial Infarction Rat Model.
TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association.
TACE and other ADAM proteases as targets for drug discovery.
TACE is required for fetal murine cardiac development and modeling.
TACE-dependent EGF receptor activation in angiotensin-II-induced kidney disease.
TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation.
Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.
Targeting of extracellular proteases required for the progression of pancreatic cancer.
Targeting the heparin-binding epidermal growth factor-like growth factor in ovarian cancer therapy.
Temporal and spatial patterns of ovarian gene transcription following an ovulatory dose of gonadotropin in the rat.
The ADAMs: signalling scissors in the tumour microenvironment.
The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM.
The Blockade of TACE-Dependent EGF Receptor Activation by Losartan-Erlotinib Combination Attenuates Renal Fibrosis Formation in 5/6-Nephrectomized Rats Under Vitamin D Deficiency.
The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3.
The continuing saga of snake venom disintegrins.
The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-?-Induced Epithelial to Mesenchymal Transition.
The disintegrin and metalloprotease Meltrin from Drosophila forms oligomers via its protein binding domain and is regulated by the homeobox protein VND during embryonic development.
The disintegrin domain of ADAM17 antagonises fibroblast?carcinoma cell interactions.
The disintegrin tzabcanin inhibits adhesion and migration in melanoma and lung cancer cells.
The disintegrin-metalloproteinases ADAM 10, 12 and 17 are upregulated in invading peripheral tumor cells of basal cell carcinomas.
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation.
The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression.
The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.
The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone.
The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma.
The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone.
The Importance of the Knee Joint Meniscal Fibrocartilages as Stabilizing Weight Bearing Structures Providing Global Protection to Human Knee-Joint Tissues.
The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model.
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease.
The role of proteolysis in Alzheimer's disease.
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression.
The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.
The TACE zymogen: re-examining the role of the cysteine switch.
The tissue-renin-angiotensin-system of the human intervertebral disc.
The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin.
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression.
Transforming growth factor-beta1-mediated activation of NF-kappaB contributes to enhanced ADAM-12 expression in mammary carcinoma cells.
Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility.
Tumor invasion induced by oxidative stress is dependent on membrane ADAM 9 protein and its secreted form.
Tumor Microenvironment-Associated Extracellular Matrix Components Regulate NK Cell Function.
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation.
Tumor necrosis factor-alpha converting enzyme.
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
Tumor necrosis factor-alpha converting enzyme: Implications for ocular inflammatory diseases.
Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.
Up-regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands.
Up-regulation of TNF-alpha convertase (TACE/ADAM17) after oxygen-glucose deprivation in rat forebrain slices.
Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma.
Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma.
Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer.
Upregulation of ADAM-17 expression in active lesions in multiple sclerosis.
Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
Upregulation of ADAM19 in chronic allograft nephropathy.
Vicrostatin - an anti-invasive multi-integrin targeting chimeric disintegrin with tumor anti-angiogenic and pro-apoptotic activities.
When spider and snake get along: Fusion of a snake disintegrin with a spider phospholipase D to explore their synergistic effects on a tumor cell.
[Expression and clinical significance of a disintegrin and metalloprotease 8 (ADAM8) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer]
[Inhibition of proliferation, adhesion and invasion ability of human lung carcinoma cell A549 by tumor necrosis factor-alpha converting enzyme (TACE)]
Nephrosis
Effects of Shenkangling intervention on the MAPK pathway in rats with doxorubicin-induced nephropathy.
Neuralgia
Inhibition of neuropathic pain by a potent disintegrin--triflavin.
Neuritis
The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine.
Neuroblastoma
Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.
ADAM15 Participates in Tick-Borne Encephalitis Virus Replication.
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid.
Neurodegenerative Diseases
Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons.
Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.
Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice.
Metalloproteases and the degradome.
Neuroinflammatory Diseases
Matrix metalloproteinases and their multiple roles in neurodegenerative diseases.
Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation.
Neuroma, Acoustic
Analysis of ADAM9 regulation and function in vestibular schwannoma primary cells.
Obesity
Inhibition of adipogenesis by RGD-dependent disintegrin.
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice.
Odontogenic Cysts
HIF-1? is Overexpressed in Odontogenic Keratocyst Suggesting Activation of HIF-1? and NOTCH1 Signaling Pathways.
Oligodendroglioma
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Osteoarthritis
ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'.
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis.
An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.
Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers.
Biologic basis of osteoarthritis: state of the evidence.
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Changes in immunolocalisation of beta-dystroglycan and specific degradative enzymes in the osteoarthritic synovium.
Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Diagnostic utility of fluorogenic peptide-conjugated Au nanoparticle probe corroborated by rabbit model of mild cartilage injury and panel of osteoarthritic patients.
Effect of inhibiting MMP13 and ADAMTS5 by intra-articular injection of small interfering RNA in a surgically induced osteoarthritis model of mice.
Effect of osteopontin on TIMP-1 and TIMP-2 mRNA in chondrocytes of human knee osteoarthritis in vitro.
Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-?B and Wnt/?-catenin signaling in-vitro and in-vivo.
Evaluating the Effects of Platelet-Rich Plasma and Amniotic Viscous Fluid on Inflammatory Markers in a Human Coculture Model for Osteoarthritis.
Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage.
Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome.
Guava leaf extract suppresses osteoarthritis progression in a rat anterior cruciate ligament transection model.
Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage.
Highly enhanced expression of the disintegrin metalloproteinase MDC15 (metargidin) in rheumatoid synovial tissue.
Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling.
Intra-articular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis.
Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes.
Long non-coding RNA HOTAIR promotes expression of ADAMTS-5 in human osteoarthritic articular chondrocytes.
Low-density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4: Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.
MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes.
Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
Nesfatin-1 suppresses interleukin-1?-induced inflammation, apoptosis, and cartilage matrix destruction in chondrocytes and ameliorates osteoarthritis in rats.
Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice.
Osteoblasts Regulate the Expression of ADAMTS and MMPs in Chondrocytes through ERK Signaling Pathway.
Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding.
Quercetin prevent proteoglycan destruction by inhibits matrix metalloproteinase-9, matrix metalloproteinase-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 expressions on osteoarthritis model rats.
Salicin inhibits AGE-induced degradation of type II collagen and aggrecan in human SW1353 chondrocytes: therapeutic potential in osteoarthritis.
SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis.
Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4.
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
The alteration of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) in the knee joints of osteoarthritis mice.
The IL-1?/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis.
The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis.
The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis.
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts.
[Research progress of a disintegrin and metalloproteinase with thrombospondin motif 4 and 5 in osteoarthritis].
Osteoarthritis, Knee
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Quantitation OF ARGS aggrecan fragments in synovial fluid, serum and urine from osteoarthritis patients.
Relationship between ADAMTS14/rs4747096 gene polymorphism and knee osteoarthritis in Chinese population.
The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis
Osteopetrosis
Multi-trait GWAS using imputed high-density genotypes from whole-genome sequencing identifies genes associated with body traits in Nile tilapia.
Osteophyte
An Update on the Emerging Role of Visfatin in the Pathogenesis of Osteoarthritis and Pharmacological Intervention.
Osteoporosis
Inhibition of osteoporosis by the ?v?3 integrin antagonist of rhodostomin variants.
Osteosarcoma
Differential expression of degradome components in cutaneous squamous cell carcinomas.
Disintegrin targeting of an ?v?3 integrin-over-expressing high-metastatic human osteosarcoma with Echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro.
Expression of a disintegrin and metalloprotease 8 and endostatin in human osteosarcoma: Implication in tumor progression and prognosis.
Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor.
IL-6 upregulates a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS-2) in human osteosarcoma cells mediated by JNK pathway.
Synergistic suppression of a disintegrin acurhagin-C in combination with AZD4547 and reparixin on terminating development for human osteosarcoma MG-63 cell.
The disintegrin echistatin in combination with doxorubicin targets high-metastatic human osteosarcoma overexpressing ???3 integrin in chick embryo and nude mouse models.
Upregulation of a Disintegrin and Metalloprotease 8 Influences Tumor Metastasis and Prognosis in Patients with Osteosarcoma.
Ovarian Neoplasms
A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model.
Aberrant expression of ADAM9 in ovarian cancer and its clinical significance.
Control of specific growth rate to enhance the production of a novel disintegrin, saxatilin, in recombinant Pichia pastoris.
Integrin alphavbeta3-mediated transcriptional regulation of TIMP-1 in a human ovarian cancer cell line.
Lysophosphatidic acid induces tumor necrosis factor-alpha to regulate a pro-inflammatory cytokine network in ovarian cancer.
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Saxatilin, a snake venom disintegrin, suppresses TNF-alpha-induced ovarian cancer cell invasion.
Targeting the heparin-binding epidermal growth factor-like growth factor in ovarian cancer therapy.
The role of CDCP1 (CUB domain-containing protein 1) and ADAM12 (a disintegrin and metalloproteinase 12) in ovarian cancer.
Pancreatic Neoplasms
ADAM9 Mediates Triple-Negative Breast Cancer Progression via AKT/NF-?B Pathway.
Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression.
Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9.
Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and ?-catenin signaling.
Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.
Multiplexed proximity ligation assays to profile putative plasma biomarkers relevant to pancreatic and ovarian cancer.
Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.
Recombinant disintegrin (r-Cam-dis) from Crotalus adamanteus inhibits adhesion of human pancreatic cancer cell lines to laminin-1 and vitronectin.
Paramyxoviridae Infections
Human parainfluenza virus type 2 (HPIV2) induced host ADAM8 expression in human salivary adenocarcinoma cell line (HSY) during cell fusion.
Periodontal Diseases
Comparative analysis of gingival crevicular fluid a disintegrin and metalloproteinase 8 levels in health and periodontal disease: A clinic-biochemical study.
Elevated Levels of A Disintegrin and Metalloproteinase 8 in Gingival Crevicular Fluid of Patients With Periodontal Diseases.
Periodontitis
Periodontitis Deteriorates Cognitive Function and Impairs Neurons and Glia in a Mouse Model of Alzheimer's Disease.
Peripheral Arterial Disease
Modulation of miR29a improves impaired post-ischemic angiogenesis in hyperglycemia.
Peripheral Nerve Injuries
Inhibition of neuropathic pain by a potent disintegrin--triflavin.
Pituitary Neoplasms
ADAM12 induces EMT and promotes cell migration, invasion and proliferation in pituitary adenomas via EGFR/ERK signaling pathway.
Pneumonia
ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.
Angiotensin-(1-7)/Mas Signaling Inhibits Lipopolysaccharide-Induced ADAM17 Shedding Activity and Apoptosis in Alveolar Epithelial Cells.
Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space.
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.
Polycystic Kidney Diseases
A Disintegrin and Metalloenzyme (ADAM) 17 Activation Is Regulated by ?5?1 Integrin in Kidney Mesangial Cells.
ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.
The epidermal growth factor receptor pathway in chronic kidney diseases.
Polycystic Kidney, Autosomal Dominant
The epidermal growth factor receptor pathway in chronic kidney diseases.
Polycystic Kidney, Autosomal Recessive
ADAM17 promotes proliferation of collecting duct kidney epithelial cells through ERK activation and increased glycolysis in polycystic kidney disease.
Polycythemia Vera
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Pre-Eclampsia
ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome.
Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy.
Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia.
The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia.
Pregnancy, Ectopic
A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy.
Disintegrin and metalloprotease and ectopic pregnancy.
Maternal serum disintegrin and metalloprotease protein-12 in early pregnancy as a potential marker of adverse pregnancy outcomes.
Premature Birth
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Prion Diseases
Apparent Reduction of ADAM10 in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents.
Prostatic Neoplasms
ADAM15 supports prostate cancer metastasis by modulating tumor cell-endothelial cell interaction.
ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer.
Androgen regulates ADAMTS15 gene expression in prostate cancer cells.
Anti-angiogenesis and RGD-containing snake venom disintegrins.
CD82 Suppresses ADAM17-Dependent E-Cadherin Cleavage and Cell Migration in Prostate Cancer.
Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.
Combined Dynamic Alterations in Urinary VEGF Levels and Tissue ADAM9 Expression as Markers for Lethal Phenotypic Progression of Prostate Cancer.
Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.
Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer.
Identification of ADAM12 as a Novel Basigin Sheddase.
Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer.
Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers.
Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17.
Preclinical evaluation of a 64Cu-labeled disintegrin for PET imaging of prostate cancer.
The disintegrin contortrostatin in combination with docetaxel is a potent inhibitor of prostate cancer in vitro and in vivo.
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression.
Psoriasis
ADAM33 as a Psoriasis Susceptibility Gene in the Han Population of Northeastern China.
Autoantigens ADAMTSL5 and LL37 are significantly upregulated in active Psoriasis and localized with keratinocytes, dendritic cells and other leukocytes.
Targeting miR-21 to treat psoriasis.
Pulmonary Disease, Chronic Obstructive
A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD.
A disintegrin and metalloprotease 33 and chronic obstructive pulmonary disease pathophysiology.
A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India.
A disintegrin and metalloproteinase domain-15 deficiency leads to exaggerated cigarette smoke-induced chronic obstructive pulmonary disease (COPD)-like disease in mice.
A Disintegrin and Metalloproteinase Domain-8: A Novel Protective Proteinase in Chronic Obstructive Pulmonary Disease.
ADAM17 Deficiency Protects against Pulmonary Emphysema.
ADAM33 gene polymorphisms in chronic obstructive pulmonary disease.
Association between F+1 polymorphism in a disintegrin and metalloprotease 33 (ADAM33) gene and chronic obstructive pulmonary disease susceptibility: An evidence-based meta-analysis.
Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls.
Association of a disintegrin and metalloproteinase 33 (ADAM33) gene polymorphisms with chronic obstructive pulmonary disease in the Chinese population: a meta-analysis.
DNA sequence variations of metalloproteinases: their role in asthma and COPD.
Genetic Variants in IL6R and ADAM19 are Associated with COPD Severity in a Mexican Mestizo Population.
Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications.
Polymorphisms in a disintegrin and metalloprotease 33 gene and the risk of chronic obstructive pulmonary disease: A meta-analysis.
Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients.
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.
Serological investigation of the collagen degradation profile of patients with chronic obstructive pulmonary disease or idiopathic pulmonary fibrosis.
The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma.
[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease].
Pulmonary Eosinophilia
Increased serum ADAM8 concentration in patients with drug-induced eosinophilic pneumonia-ADAM8 expression depends on a the allergen route of entry.
Purpura
Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events.
DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related?
Effectiveness of Caplacizumab Nanobody in Acquired Thrombotic Thrombocytopenic Purpura Refractory to Conventional Treatment.
Emerging roles of adjunct therapies in acquired thrombotic thrombocytopenia purpura.
Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy.
Purpura, Thrombocytopenic, Idiopathic
A successfully treated case of an acute presentation of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) with decreased ADAMTS13 during late stage of pregnancy.
Purpura, Thrombotic Thrombocytopenic
A human monoclonal antibody against the distal carboxyl terminus of ADAMTS-13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura.
A multicenter laboratory assessment of a new automated chemiluminescent assay for ADAMTS13 activity.
A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13.
Absence of exaggerated pharmacology by recombinant ADAMTS13 in the rat and monkey.
ADAMTS-13 antigen and activity levels in thrombocytopenic disorders including thrombotic thrombocytopenic purpura in Kuwait.
ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies.
ADAMTS13 related markers and von Willebrand factor in plasma from patients with thrombotic microangiopathy (TMA).
ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment.
Aggressive Disease and Rare Sequelae in a Unique Case of Atypical Hemolytic Uremic Syndrome Secondary to Adult Onset Still's Disease.
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Anti-ADAMTS13 autoantibody profiling in patients with immune-mediated thrombotic thrombocytopenic purpura.
Atypical hemolytic uremic syndrome: a syndrome in need of clarity.
Bethesda Assay for Detecting Inhibitory Anti-ADAMTS13 Antibodies in Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Bortezomib in the treatment of refractory thrombotic thrombocytopenic purpura.
Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura.
CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides.
Chest pain with increased troponin level; not always a cardiology issue.
Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.
Cholangiocarcinoma presenting with acquired thrombotic thrombocytopenic purpura confirmed by positive autoantibodies of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13.
Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies.
Clinical features and outcomes in patients with thrombotic microangiopathy not associated with severe ADAMTS13 deficiency.
Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura.
Congenital Thrombotic Thrombocytopenic Purpura Associated With Moyamoya Syndrome in a 3-Year-Old Girl: A Case Report.
Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene.
Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.
Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Cost-effectiveness of thrombotic thrombocytopenic purpura diagnosis: a retrospective analysis in the University Hospital Center of Lyon (France).
COVID-19 as a Potential Trigger for Immune Thrombotic Thrombocytopenic Purpura and Reason for an Unusual Treatment: A Case Report.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Decreased ADAMTS13 activity in plasma from patients with thrombotic thrombocytopenic purpura.
Determination of anti-ADAMTS-13 autoantibody titers in ELISA: Influence of ADAMTS-13 presentation and autoantibody detection.
Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay.
Diagnostic relevance of ADAMTS13 activity: evaluation of 28 patients with thrombotic thrombocytopenic purpura - hemolytic uremic syndrome clinical diagnosis.
Double positivity of anti-?2-glycoprotein I domain I and anti-phosphatidylserine/prothrombin antibodies enhances both thrombosis and positivity of anti-ADAMTS13 antibody.
Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura.
Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura.
Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy.
Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity.
Exome Sequencing Identifies Abnormalities in Glycosylation and ANKRD36C in Patients with Immune-Mediated Thrombotic Thrombocytopenic Purpura.
Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura.
Genetic and Functional Characterization of ADAMTS13 Variants in a Patient Cohort with Upshaw-Schulman Syndrome Investigated in Germany.
High-resolution epitope mapping by HX MS reveals the pathogenic mechanism and a possible therapy for autoimmune TTP syndrome.
Identification of a crucial tryptophan residue in ADAMTS13 required for its secretion and enzymatic activity.
Imbalance of von Willebrand factor and ADAMTS13 axis is rather a biomarker of strong inflammation and endothelial damage than a cause of thrombotic process in critically ill COVID-19 patients.
Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease.
Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.
Inherited thrombotic thrombocytopenic purpura in children.
Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review.
Insights into ADAMTS13 structure: impact on thrombotic thrombocytopenic purpura diagnosis and management.
N-Acetylcysteine for Relapsing Thrombotic Thrombocytopenic Purpura: More Evidence of a Promising Drug.
Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
Novel Heterozygous Mutations of Congenital Thrombotic Thrombocytopenic Purpura: A Rare Case Report.
Novel therapeutic approaches for thrombotic thrombocytopenic purpura.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Plasma Levels of Big Endothelin-1 Are Associated with Renal Insufficiency and In-Hospital Mortality of Immune Thrombotic Thrombocytopenic Purpura.
Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro.
Presenting ADAMTS13 on a TTP-associated MHC.
Reduced ADAMTS13 activity in delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.
Remission of Severe, Relapsed, and Refractory TTP after Multiple Cycles of Bortezomib.
Rituximab was effective on refractory thrombotic thrombocytopenic purpura but induced a flare of hemophagocytic syndrome in a patient with systemic lupus erythematosus.
Rituximab-refractory thrombotic thrombocytopenic purpura responsive to intravenous but not subcutaneous bortezomib.
Successful management of three patients with autoimmune thrombotic thrombocytopenic purpura with paradigm-changing therapy: Caplacizumab, steroids, plasma exchange, rituximab, and intravenous immunoglobulins (CASPERI).
The ADAMTS13(1239-1253) peptide is a dominant HLA-DR1-restricted CD4+ T-cell epitope.
The clinical utility of ADAMTS13 activity, antigen and autoantibody assays in thrombotic thrombocytopenic purpura.
The course of ADAMTS-13 activity and inhibitor titre in the treatment of thrombotic thrombocytopenic purpura with plasma exchange and vincristine.
The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical andin silico study.
The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians.
The role of ADAMTS13 in the pathogenesis of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome.
The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry.
Thrombosis, Microangiopathies, and Inflammation.
Thrombotic microangiopathies assessment: mind the complement.
Thrombotic thrombocytopenic purpura during pregnancy versus imitator of preeclampsia.
Thrombotic thrombocytopenic purpura in children.
Thrombotic Thrombocytopenic Purpura Masquerading as Acute Ischemic Stroke.
Thrombotic thrombocytopenic purpura related to severe ADAMTS13 deficiency in children.
Thrombotic thrombocytopenic purpura-what is new?
Thrombotic Thrombocytopenic Purpura: Beyond Empiricism and Plasma Exchange.
Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions.
Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome.
Upshaw-Schulman Syndrome With c.2728C>T Mutation in ADAMTS13 Gene.
Von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura.
VWF excess and ADAMTS13 deficiency: a unifying pathomechanism linking inflammation to thrombosis in DIC, malaria, and TTP.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
[Biological Function of CysR Domain of ADAMTS13].
[Thrombotic microangiopathy].
receptor protein-tyrosine kinase deficiency
Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.
Renal Insufficiency
Deficiency in mouse hyaluronidase 2: a new mechanism of chronic thrombotic microangiopathy.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Renal Insufficiency, Chronic
A Disintegrin and Metalloenzyme (ADAM) 17 Activation Is Regulated by ?5?1 Integrin in Kidney Mesangial Cells.
ADAMTS-13 deficiency: can it cause chronic renal failure?
Circulating ADAMs are associated with renal and cardiovascular outcomes in chronic kidney disease patients.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
The epidermal growth factor receptor pathway in chronic kidney diseases.
Reoviridae Infections
A functional role for ADAM10 in human immunodeficiency virus type-1 replication.
Reperfusion Injury
Trimucrin, an Arg-Gly-Asp containing disintegrin, attenuates myocardial ischemia-reperfusion injury in murine by inhibiting platelet function.
Respiratory Hypersensitivity
ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease.
Retinal Neovascularization
Characterization of the Catalytic Properties of the Membrane-anchored Metalloprotease ADAM9 in Cell-based assays.
Rhabdomyosarcoma, Embryonal
A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo.
Rhinitis
Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
Rhinitis, Allergic
ADAM33 polymorphisms and susceptibility to allergic rhinitis: a meta-analysis.
Association between ADAM33 S2 and V4 polymorphisms and susceptibility to allergic rhinitis: A meta-analysis.
Increased expression of a disintegrin and metalloprotease 8 in allergic rhinitis.
Sarcoidosis, Pulmonary
A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis.
Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis.
Sarcoma
Novel role of microRNA-126 in digestive system cancers: From bench to bedside.
The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model.
The effect of microRNA-330 replacement on inhibition of growth and migration in renal cancer cells.
Sepsis
MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression.
miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes.
Plasmapheresis in Sepsis-induced Thrombotic Microangiopathy: A Case Series.
Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C.
Snake Venom Disintegrin Inhibits the Activation of Toll-Like Receptors and Alleviates Sepsis through Integrin alphaVbeta3 Blockade.
The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
Severe Acute Respiratory Syndrome
ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2.
Shock, Septic
Local Epidermal Growth Factor Receptor Signaling Mediates the Systemic Pathogenic Effects of Staphylococcus aureus Toxic Shock Syndrome.
The prognostic value of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency in septic shock patients involves interleukin-6 and is not dependent on disseminated intravascular coagulation.
Skin Diseases
A disintegrin and metalloprotease (ADAM) 33 protein in patients with pulmonary sarcoidosis.
Spinal Cord Injuries
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Squamous Cell Carcinoma of Head and Neck
ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC.
Expression of "a disintegrin and metalloproteinase-33" (ADAM-33) protein in laryngeal squamous cell carcinoma.
Expression profiles and clinical correlations of degradome components in the tumor microenvironment of head and neck squamous cell carcinoma.
Involvement of NF-kappaB-mediated maturation of ADAM-17 in the invasion of oral squamous cell carcinoma.
Overexpression of A disintegrin and metalloprotease 10 promotes tumor proliferation, migration and poor prognosis in hypopharyngeal squamous cell carcinoma.
Stomach Neoplasms
A Disintegrin and Metalloproteinase 8 as a Potential Blood Biomarker for Early Diagnosis of Gastric Cancer.
Downregulation of A disintegrin and metallopeptidase with thrombospondin motif type 1 by DNA hypermethylation in human gastric cancer.
Identified a disintegrin and metalloproteinase with thrombospondin motifs 6 serve as a novel gastric cancer prognostic biomarker by bioinformatics analysis.
Prognostic Significance of ADAM17 for Gastric Cancer Survival: A Meta-Analysis.
The effect of disintegrin-metalloproteinase ADAM9 in gastric cancer progression.
Upregulated Expression of ADAM17 Is a Prognostic Marker for Patients With Gastric Cancer.
Upregulation of a disintegrin and metalloprotease 8 is associated with progression and prognosis of patients with gastric cancer.
Stroke
ADAMTS12, a new candidate gene for pediatric stroke.
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology.
Matrix metalloproteinases and ADAMs in stroke.
Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice.
Role of reduced ADAMTS13 in arterial ischemic stroke: a pediatric cohort study.
Tendinopathy
Tendinopathy--from basic science to treatment.
Thrombocytopenia
A Difficult Diagnosis Case of Prolonged Thrombocytopenia With Sepsis and Disseminated Intravascular Coagulation.
Anti-thrombotic agents derived from snake venom proteins.
Caplacizumab to treat immune-mediated thrombotic thrombocytopenic purpura.
Congenital thrombotic thrombocytopenic purpura presenting in adulthood with recurrent cerebrovascular events.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Emerging roles of adjunct therapies in acquired thrombotic thrombocytopenia purpura.
From Discovery of Snake Venom Disintegrins to A Safer Therapeutic Antithrombotic Agent.
Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease.
Infection as Trigger for Congenital Thrombotic Thrombocytopenic Purpura in an Adult Patient.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Limitations of ADAMTS-13 Activity Level in Diagnosing Thrombotic Thrombocytopenic Purpura in Pregnancy.
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab.
Secondary thrombotic microangiopathy with severely reduced ADAMTS13 activity in a patient with Capnocytophaga canimorsus sepsis: a case report.
Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.
What's new in the diagnosis and pathophysiology of thrombotic thrombocytopenic purpura.
Thrombosis
Actin polymerization regulates glycoprotein Ib? shedding.
ADAMTS-13 in the Diagnosis and Management of Thrombotic Microangiopathies.
ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis.
ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice.
ADAMTS13: An Emerging Target in Stroke Therapy.
AFM Imaging Reveals Multiple Conformational States of ADAMTS13.
Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction.
Balance between von Willebrand factor and ADAMTS13 following major partial hepatectomy.
Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.
cDNA cloning of a snake venom metalloproteinase from the eastern diamondback rattlesnake (Crotalus adamanteus), and the expression of its disintegrin domain with anti-platelet effects.
Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus.
Congenital ADAMTS-13 deficiency presenting as life-threatening thrombosis during pregnancy.
Correction to: Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Effect of recombinant ADAMTS13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage.
Evaluation of the disintegrin, triflavin, in a rat middle cerebral artery thrombosis model.
Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease.
Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura.
Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.
Increased dipeptidyl peptidase-4 accelerates chronic stress-related thrombosis in a mouse carotid artery model.
Plasma von Willebrand Factor and a Disintegrin and Metalloproteinase with Eight Thrombospondin-type 1 Motif Levels in Hemodialysis Patients: Relation to Vascular Access Thrombosis.
Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin.
Synergistic effect of aurintricarboxylic acid and triflavin in a photochemically induced thrombosis model in rats.
Thrombolytic effects of the snake venom disintegrin saxatilin determined by novel assessment methods: a FeCl3-induced thrombosis model in mice.
Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura.
Vascular thrombus imaging in vivo via near-infrared fluorescent nanodiamond particles bioengineered with the disintegrin bitistatin (Part II).
[Stable expression and characterization of the von Willebrand factor cleaving protease]
Thrombotic Microangiopathies
A Case of Recurrent Thrombotic Microangiopathy Caused by Hypertensive Urgency.
A human monoclonal antibody against the distal carboxyl terminus of ADAMTS-13 modulates its susceptibility to an inhibitor in thrombotic thrombocytopenic purpura.
A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13.
ADAMTS-13 deficiency: can it cause chronic renal failure?
ADAMTS13 related markers and von Willebrand factor in plasma from patients with thrombotic microangiopathy (TMA).
Attending rounds: microangiopathic hemolytic anemia with renal insufficiency.
Autoimmune thrombotic microangiopathy: advances in pathogenesis, diagnosis, and management.
Chest pain with increased troponin level; not always a cardiology issue.
Child-onset and adolescent-onset acquired thrombotic thrombocytopenic purpura with severe ADAMTS13 deficiency: a cohort study of the French national registry for thrombotic microangiopathy.
Clinical features and outcomes in patients with thrombotic microangiopathy not associated with severe ADAMTS13 deficiency.
Comparison of Rituximab originator (MabThera) to biosimilar (Truxima) in patients with immune-mediated thrombotic thrombocytopenic purpura.
Congenital thrombotic thrombocytopenic purpura caused by new compound heterozygous mutations of the ADAMTS13 gene.
Current management and therapeutical perspectives in thrombotic thrombocytopenic purpura.
Diabetic ketoacidosis presenting with atypical hemolytic uremic syndrome associated with a variant of complement factor B in an adult: a case report.
Diagnosis and follow-up of thrombotic thrombocytopenic purpura with an automated chemiluminescent ADAMTS13 activity immunoassay.
Donor Age Affects Liver Regeneration during Early Period in the Graft Liver and Late Period in the Remnant Liver after Living Donor Liver Transplantation.
Epidemiology and pathophysiology of adulthood-onset thrombotic microangiopathy with severe ADAMTS13 deficiency (thrombotic thrombocytopenic purpura): a cross-sectional analysis of the French national registry for thrombotic microangiopathy.
Evaluation of a New, Rapid, Fully Automated Assay for the Measurement of ADAMTS13 Activity.
Influenza-associated thrombotic microangiopathy with unbalanced von Willebrand factor and a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 levels in a heterozygous protein S-deficient boy.
Inherited Thrombotic Thrombocytopenic Purpura Revealed by Recurrent Strokes in a Male Adult: Case Report and Literature Review.
Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.
Intensive plasma exchange increases ADAMTS-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.
Natural history of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome.
Novel therapeutic approaches for thrombotic thrombocytopenic purpura.
Obstetric Nephrology: AKI and Thrombotic Microangiopathies in Pregnancy.
Pathophysiology of Pediatric Multiple Organ Dysfunction Syndrome.
Performance of Diagnostic Scores in Thrombotic Microangiopathy Patients in the Intensive Care Unit: A Monocentric Study.
Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C.
The D173G mutation in ADAMTS-13 causes a severe form of congenital thrombotic thrombocytopenic purpura. A clinical, biochemical andin silico study.
The HLA Variant rs6903608 Is Associated with Disease Onset and Relapse of Immune-Mediated Thrombotic Thrombocytopenic Purpura in Caucasians.
The utility of ADAMTS13 in differentiating TTP from other acute thrombotic microangiopathies: results from the UK TTP Registry.
Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy.
Unresponsive Thrombotic Thrombocytopenic Purpura (TTP): Challenges and Solutions.
Triple Negative Breast Neoplasms
miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells.
N-glycosylation regulates ADAM8 processing and activation.
Tuberculosis
Serum concentrations of A disintegrin and metalloproteinase 9 (ADAM9) mRNA as a promising novel marker for the detection of pulmonary sarcoidosis.
Tuberculosis, Spinal
Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.
Ureteral Obstruction
Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction.
Urinary Bladder Neoplasms
Expression and Clinical Significance of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) and a Disintegrin and Metalloproteinase with Thrombospondin Type 1 Motif 1 (ADAMTS1) in Post-Kidney-Transplant Bladder Tumors.
The microRNA miR-3174 Suppresses the Expression of ADAM15 and Inhibits the Proliferation of Patient-Derived Bladder Cancer Cells.
Urogenital Neoplasms
Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.
Uveitis
The disintegrin domain of ADAM 8 enhances protection against rat experimental autoimmune encephalomyelitis, neuritis and uveitis by a polyvalent autoantigen vaccine.
Vascular Diseases
A disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) expression increases in acute aortic dissection.
ADAMTS-5 Decreases in Aortas and Plasma From Aortic Dissection Patients and Alleviates Angiotensin II-Induced Smooth Muscle-Cell Apoptosis.
Adamts18 modulates the development of the aortic arch and common carotid artery.
Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.
High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation.
The Antiatherogenic Effect of Fish Oil in Male Mice Is Associated with a Diminished Release of Endothelial ADAM17 and ADAM10 Substrates.
Vascular System Injuries
Exosite interactions contribute to tension-induced cleavage of von Willebrand factor by the antithrombotic ADAMTS13 metalloprotease.
Vasculitis
Hypertensive emergency presenting with diffuse alveolar hemorrhaging and thrombotic microangiopathy: A case report and review of the literature.
Virus Diseases
A Disintegrin and Metalloproteinase 9 Domain (ADAM9) Is a Major Susceptibility Factor in the Early Stages of Encephalomyocarditis Virus Infection.
ADAM10 Partially Protects Mice against Influenza Pneumonia by Suppressing Specific Myeloid Cell Population.
Interferon induced thrombotic microangiopathy (TMA): Analysis and concise review.
Vitamin B 12 Deficiency
Atypical hemolytic uremic syndrome and complement blockade: established and emerging uses of complement inhibition.
von Willebrand Disease, Type 1
An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13.
von Willebrand Diseases
An amino acid polymorphism in von Willebrand factor correlates with increased susceptibility to proteolysis by ADAMTS13.
Weill-Marchesani Syndrome
ADAMTS Proteinases: Potential Therapeutic Targets?