Reference on EC 3.4.23.49 - omptin
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Sugimura, K.; Nishihara, T.
Purification, characterization, and primary structure of Escherichia coli protease VII with specificity for paired basic residues: identity of protease VII and OmpT
J. Bacteriol.
170
5625-5632
1988
Escherichia coli
Hanke, C.; Hess, J.; Schumacher, G.; Goebel, W.
Processing by OmpT of fusion proteins carrying the HlyA transport signal during secretion by the Escherichia coli hemolysin transport system
Mol. Gen. Genet.
233
42-48
1992
Escherichia coli
Grodberg, J.; Lundrigan, M.D.; Toledo, D.L.; Mangel, W.F.; Dunn, J.J.
Complete nucleotide sequence and deduced amino acid sequence of the ompT gene of Escherichia coli K-12
Nucleic Acids Res.
16
1209
1988
Escherichia coli
Mangel, W.F.; Toledo, D.L.; Brown, M.T.; Worzalla, K.; Lee, M.; Dunn, J.J.
Omptin: an Escherichia coli outer membrane proteinase that activates plasminogen
Methods Enzymol.
244
384-399
1994
Escherichia coli
White, C.B.; Chen, Q.; Kenyon, G.L.; Babbitt, P.C.
A novel activity of OmpT. Proteolysis under extreme denaturing conditions
J. Biol. Chem.
270
12990-12994
1995
Escherichia coli
Zhao, G.P.; Somerville, R.L.
An amino acid switch (Gly281-->Arg) within the hinge region of the tryptophan synthase beta subunit creates a novel cleavage site for the OmpT protease and selectively diminishes affinity toward a specific monoclonal antibody
J. Biol. Chem.
268
14912-14920
1993
Escherichia coli
Dekker, N.; Cox, R.C.; Kramer, R.A.; Egmond, M.R.
Substrate specificity of the integral membrane protease ompT determined by spatially addressed peptide libraries
Biochemistry
40
1694-1701
2001
Escherichia coli
Goldberg, M.D.; Canvin, J.R.; Freestone, P.; Andersen, C.; Laoudj, D.; Williams, P.H.; Holland, I.B.; Norris, V.
Artifactual cleavage of E. coli H-NS by OmpT
Biochimie
79
315-322
1997
Escherichia coli
Okuno, K.; Yabuta, M.; Kawanishi, K.; Ohsuye, K.; Ooi, T.; Kinoshita, S.
Substrate specificity at the P1' site of Escherichia coli OmpT under denaturing conditions
Biosci. Biotechnol. Biochem.
66
127-134
2002
Escherichia coli, no activity in Escherichia coli, no activity in Escherichia coli W3110 / ATCC 27325
Okuno, K.; Yabuta, M.; Ohsuye, K.; Ooi, T.; Kinoshita, S.
An analysis of target preferences of Escherichia coli outer-membrane endoprotease OmpT for use in therapeutic peptide production: efficient cleavage of substrates with basic amino acids at the P4 and P6 positions
Biotechnol. Appl. Biochem.
36
77-84
2002
Escherichia coli, no activity in Escherichia coli, no activity in Escherichia coli W3110 / ATCC 27325
Vandeputte-Rutten, L.; Kramer, R.A.; Kroon, J.; Dekker, N.; Egmond, M.R.; Gros, P.
Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site
EMBO J.
20
5033-5039
2001
Escherichia coli
Kramer, R.A.; Zandwijken, D.; Egmond, M.R.; Dekker, N.
In vitro folding, purification and characterization of Escherichia coli outer membrane protease OmpT
Eur. J. Biochem.
267
885-893
2000
Escherichia coli
Kramer, R.A.; Vandeputte-Rutten, L.; de Roon, G.J.; Gros, P.; Dekker, N.; Egmond, M.R.
Identification of essential acidic residues of outer membrane protease OmpT supports a novel active site
FEBS Lett.
505
426-430
2001
Escherichia coli
Okuno, K.; Yabuta, M.; Ooi, T.; Kinoshita, S.
Utilization of Escherichia coli outer-membrane endoprotease OmpT variants as processing enzymes for production of peptides from designer fusion proteins
Appl. Environ. Microbiol.
70
76-86
2004
Escherichia coli
Baaden, M.; Sansom, M.S.
OmpT: molecular dynamics simulations of an outer membrane enzyme
Biophys. J.
87
2942-2953
2004
Escherichia coli
Brandenburg, K.; Garidel, P.; Schromm, A.B.; Andra, J.; Kramer, A.; Egmond, M.; Wiese, A.
Investigation into the interaction of the bacterial protease OmpT with outer membrane lipids and biological activity of OmpT:lipopolysaccharide complexes
Eur. Biophys. J.
34
28-41
2005
Escherichia coli
Kukkonen, M.; Korhonen, T.K.
The omptin family of enterobacterial surface proteases/adhesins: from housekeeping in Escherichia coli to systemic spread of Yersinia pestis
Int. J. Med. Microbiol.
294
7-14
2004
Escherichia coli, Salmonella enterica, Yersinia pestis, Shigella flexneri, Erwinia pyrifoliae
McCarter, J.D.; Stephens, D.; Shoemaker, K.; Rosenberg, S.; Kirsch, J.F.; Georgiou, G.
Substrate specificity of the Escherichia coli outer membrane protease OmpT
J. Bacteriol.
186
5919-5925
2004
Escherichia coli K-12
Varadarajan, N.; Gam, J.; Olsen, M.J.; Georgiou, G.; Iverson, B.L.
Engineering of protease variants exhibiting high catalytic activity and exquisite substrate selectivity
Proc. Natl. Acad. Sci. USA
102
6855-6860
2005
Escherichia coli
Neri, M.; Baaden, M.; Carnevale, V.; Anselmi, C.; Maritan, A.; Carloni, P.
Microseconds dynamics simulations of the outer-membrane protease T
Biophys. J.
94
71-78
2008
Escherichia coli (P09169), Escherichia coli
Ono, B.; Kimiduka, H.; Kubota, M.; Okuno, K.; Yabuta, M.
Role of the ompT mutation in stimulated decrease in colony-forming ability due to intracellular protein aggregate formation in Escherichia coli strain BL21
Biosci. Biotechnol. Biochem.
71
504-512
2007
Escherichia coli (P09169)
Chaparro-Riggers, J.F.; Breves, R.; Maurer, K.H.; Bornscheuer, U.
Modulation of infectivity in phage display as a tool to determine the substrate specificity of proteases
Chembiochem
7
965-970
2006
Escherichia coli (P09169)
Masi, M.; Vuong, P.; Humbard, M.; Malone, K.; Misra, R.
Initial steps of colicin E1 import across the outer membrane of Escherichia coli
J. Bacteriol.
189
2667-2676
2007
Escherichia coli (P09169)
Hwang, B.Y.; Varadarajan, N.; Li, H.; Rodriguez, S.; Iverson, B.L.; Georgiou, G.
Substrate specificity of the Escherichia coli outer membrane protease OmpP
J. Bacteriol.
189
522-530
2007
Escherichia coli (P09169), Escherichia coli (P34210), Escherichia coli
Li, H.; Lin, X.M.; Wang, S.Y.; Peng, X.X.
Identification and antibody-therapeutic targeting of chloramphenicol-resistant outer membrane proteins in Escherichia coli
J. Proteome Res.
6
3628-3636
2007
Escherichia coli (P09169)
Duche, D.; Issouf, M.; Lloubes, R.
Immunity protein protects colicin E2 from OmpT protease
J. Biochem.
145
95-101
2009
Escherichia coli
Duret, G.; Delcour, A.H.
Size and dynamics of the Vibrio cholerae porins OmpU and OmpT probed by polymer exclusion
Biophys. J.
98
1820-1829
2010
Vibrio cholerae serotype O1
Yun, T.; Cott, J.; Tapping, R.; Slauch, J.; Morrissey, J.
Proteolytic inactivation of tissue factor pathway inhibitor by bacterial omptins
Blood
113
1139-1148
2009
Escherichia coli, Salmonella enterica
Zanfardino, A.; Pizzo, E.; Di Maro, A.; Varcamonti, M.; DAlessio, G.
The bactericidal action on Escherichia coli of ZF-RNase-3 is triggered by the suicidal action of the bacterium OmpT protease
FEBS J.
277
1921-1928
2010
Escherichia coli DH5[alpha], Escherichia coli DH5-alpha
Salunkhe, S.S.; Raiker, V.A.; Rewanwar, S.; Kotwal, P.; Kumar, A.; Padmanabhan, S.
Enhanced fluorescent properties of an OmpT site deleted mutant of green fluorescent protein
Microb. Cell Fact.
9
26
2010
Escherichia coli
Le Sage, V.; Zhu, L.; Lepage, C.; Portt, A.; Viau, C.; Daigle, F.; Gruenheid, S.; Le Moual, H.
An outer membrane protease of the omptin family prevents activation of the Citrobacter rodentium PhoPQ two-component system by antimicrobial peptides
Mol. Microbiol.
74
98-111
2009
Citrobacter rodentium ICC168 (D2TNS3)
Haiko, J.; Laakkonen, L.; Westerlund-Wikstroem, B.; Korhonen, T.K.
Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla
BMC Evol. Biol.
11
43
2011
Erwinia pyrifoliae
Thomassin, J.L.; Brannon, J.R.; Gibbs, B.F.; Gruenheid, S.; Le Moual, H.
OmpT outer membrane proteases of enterohemorrhagic and enteropathogenic Escherichia coli contribute differently to the degradation of Human LL-37
Infect. Immun.
80
483-492
2012
Escherichia coli, Escherichia coli EHEC O157:H7, Escherichia coli EPEC / E2348/69
Hui, C.Y.; Guo, Y.; He, Q.S.; Peng, L.; Wu, S.C.; Cao, H.; Huang, S.H.
Escherichia coli outer membrane protease OmpT confers resistance to urinary cationic peptides
Microbiol. Immunol.
54
452-459
2010
Escherichia coli, Escherichia coli E44
Tagai, C.; Morita, S.; Shiraishi, T.; Miyaji, K.; Iwamuro, S.
Antimicrobial properties of arginine- and lysine-rich histones and involvement of bacterial outer membrane protease T in their differential mode of actions
Peptides
32
2003-2009
2011
Escherichia coli, Escherichia coli JCM 5491
Jaervinen, H.M.; Laakkonen, L.; Haiko, J.; Johansson, T.; Juuti, K.; Suomalainen, M.; Buchrieser, C.; Kalkkinen, N.; Korhonen, T.K.
Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues
Mol. Microbiol.
89
507-517
2013
Escherichia coli, Salmonella enterica, Salmonella enterica 14028R, Yersinia pestis (P17811), Yersinia pestis
da Silva, R.R.; de Oliveira, L.C.; Juliano, M.A.; Juliano, L.; de Oliveira, A.H.; Rosa, J.C.; Cabral, H.
Biochemical and milk-clotting properties and mapping of catalytic subsites of an extracellular aspartic peptidase from basidiomycete fungus Phanerochaete chrysosporium
Food Chem.
225
45-54
2017
Phanerodontia chrysosporium
Wood, S.E.; Sinsinbar, G.; Gudlur, S.; Nallani, M.; Huang, C.F.; Liedberg, B.; Mrksich, M.
A bottom-up proteomic approach to identify substrate specificity of outer-membrane protease OmpT
Angew. Chem. Int. Ed. Engl.
56
16531-16535
2017
Escherichia coli (P09169)
Hui, C.Y.; Guo, Y.; Liu, L.; Zheng, H.Q.; Wu, H.M.; Zhang, L.Z.; Zhang, W.
Development of a novel bacterial surface display system using truncated OmpT as an anchoring motif
Biotechnol. Lett.
41
763-777
2019
Escherichia coli (P09169), Escherichia coli
Riva, R.; Korhonen, T.K.; Meri, S.
The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H
Front. Microbiol.
6
63
2015
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium 14028R
Brannon, J.R.; Burk, D.L.; Leclerc, J.M.; Thomassin, J.L.; Portt, A.; Berghuis, A.M.; Gruenheid, S.; Le Moual, H.
Inhibition of outer membrane proteases of the omptin family by aprotinin
Infect. Immun.
83
2300-2311
2015
Citrobacter rodentium, Escherichia coli (P09169), Escherichia coli
Samykannu, G.; Vijayababu, P.; Natarajan, J.
Substrate specificities in Salmonella typhi outer membrane protease (PgtE) from omptin family - an in silico proteomic approach
Inform. Med. Unlocked
12
6-13
2018
Salmonella enterica subsp. enterica serovar Typhi (Q8Z4Y4)
-
Brannon, J.R.; Thomassin, J.L.; Gruenheid, S.; Le Moual, H.
Antimicrobial peptide conformation as a structural determinant of omptin protease specificity
J. Bacteriol.
197
3583-3591
2015
Citrobacter rodentium, Escherichia coli (P58603), Escherichia coli, Citrobacter rodentium ATCC 51459, Citrobacter rodentium DBS 100, Escherichia coli EDL933 (P58603)
Korhonen, T.K.
Fibrinolytic and procoagulant activities of Yersinia pestis and Salmonella enterica
J. Thromb. Haemost.
13 Suppl 1
S115-S120
2015
Salmonella enterica subsp. enterica serovar Typhimurium (P06185), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (P06185), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P06185)
Feodorova, V.A.; Lyapina, A.M.; Zaitsev, S.S.; Khizhnyakova, M.A.; Sayapina, L.V.; Ulianova, O.V.; Ulyanov, S.S.; Motin, V.L.
New promising targets for synthetic omptin-based peptide vaccine against Gram-negative pathogens
Vaccines (Basel)
7
36
2019
Salmonella enterica subsp. enterica serovar Typhimurium (P06185), Escherichia coli (P09169), Escherichia coli (P34210), Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412 (P06185), Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 (P06185)
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