Disease on EC 3.4.23.24 - Candidapepsin
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Acquired Immunodeficiency Syndrome
Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection.
Acquired Immunodeficiency Syndrome
Enhanced extracellular production of aspartyl proteinase, a virulence factor, by Candida albicans isolates following growth in subinhibitory concentrations of fluconazole.
Acquired Immunodeficiency Syndrome
In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.
Acquired Immunodeficiency Syndrome
Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.
Acquired Immunodeficiency Syndrome
The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus.
Acquired Immunodeficiency Syndrome
[Highly Active AntiRetroviral Therapy and cryptosporidiosis]
Adenocarcinoma
Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.
Alzheimer Disease
A G-Rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.
Alzheimer Disease
A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds.
Alzheimer Disease
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
Alzheimer Disease
A peptide binding to the ?-site of APP improves spatial memory and attenuates A? burden in Alzheimer's disease transgenic mice.
Alzheimer Disease
A?42 oligomers modulate ?-secretase through an XBP-1s-dependent pathway involving HRD1.
Alzheimer Disease
APH-1A Component of ?-Secretase Forms an Internal Water and Ion-Containing Cavity.
Alzheimer Disease
Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates.
Alzheimer Disease
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
Alzheimer Disease
Assigning the protonation states of the key aspartates in beta-Secretase using QM/MM X-ray structure refinement.
Alzheimer Disease
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Alzheimer Disease
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Alzheimer Disease
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.
Alzheimer Disease
BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
Alzheimer Disease
Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1-calcium interaction.
Alzheimer Disease
Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene.
Alzheimer Disease
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
Alzheimer Disease
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
Alzheimer Disease
Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible lead for Alzheimer's Disease.
Alzheimer Disease
Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design.
Alzheimer Disease
Determination of the protonation state for the catalytic dyad in ?-secretase when bound to hydroxyethylamine transition state analogue inhibitors: A molecular dynamics simulation study.
Alzheimer Disease
Development of a specific ELISA to measure BACE1 levels in human tissues.
Alzheimer Disease
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
Alzheimer Disease
Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of ?-Secretase (BACE1) through Fragment-Based Drug Design.
Alzheimer Disease
Discovery of AM-6494: A Potent and Orally Efficacious ?-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.
Alzheimer Disease
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Alzheimer Disease
Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of {gamma}-Secretase.
Alzheimer Disease
Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage.
Alzheimer Disease
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.
Alzheimer Disease
Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro.
Alzheimer Disease
Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering.
Alzheimer Disease
Gadd153 and NF-?B Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and ?-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells.
Alzheimer Disease
Gene structure and organization of the human beta-secretase (BACE) promoter.
Alzheimer Disease
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
Alzheimer Disease
Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.
Alzheimer Disease
In vivo Reconstitution of {gamma}-Secretase in Drosophila Results in Substrate Specificity.
Alzheimer Disease
Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.
Alzheimer Disease
Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease.
Alzheimer Disease
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.
Alzheimer Disease
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Alzheimer Disease
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Alzheimer Disease
Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli.
Alzheimer Disease
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Alzheimer Disease
Leptin attenuates BACE1 expression and amyloid-? genesis via the activation of SIRT1 signaling pathway.
Alzheimer Disease
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Alzheimer Disease
Modeling the protonation states of ?-secretase binding pocket by molecular dynamics simulations and docking studies.
Alzheimer Disease
Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
Alzheimer Disease
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Alzheimer Disease
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
Alzheimer Disease
pH-dependent conformational dynamics of beta-secretase 1: A molecular dynamics study.
Alzheimer Disease
Population density analysis for determining the protonation state of the catalytic dyad in BACE1-tertiary carbinamine-based inhibitor complex.
Alzheimer Disease
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
Alzheimer Disease
Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.
Alzheimer Disease
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.
Alzheimer Disease
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
Alzheimer Disease
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects.
Alzheimer Disease
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Alzheimer Disease
Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.
Alzheimer Disease
Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.
Alzheimer Disease
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
Alzheimer Disease
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
Alzheimer Disease
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
Alzheimer Disease
The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve.
Alzheimer Disease
The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond.
Alzheimer Disease
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects.
Alzheimer Disease
Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
Breast Neoplasms
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Breast Neoplasms
Cathepsin D in primary breast carcinoma: adverse prognosis is associated with expression of cathepsin D in stromal cells.
Breast Neoplasms
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Breast Neoplasms
Characterization of purified cathepsin D from malignant human breast tissue.
Breast Neoplasms
Clinical significance of pepsinogen C tumor expression in patients with stage D2 prostate carcinoma.
Breast Neoplasms
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Breast Neoplasms
Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols defines a group of node negative breast cancer patients with low risk of recurrence.
Breast Neoplasms
Mitogenic activity toward human breast cancer cell line MCF-7 of two bFGFs purified from sera of breast cancer patients: co-operative role of cathepsin D.
Breast Neoplasms
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Breast Neoplasms
Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner.
Breast Neoplasms
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
Candidiasis
A modified in situ RT-PCR method for localizing fungal-specific gene expression in Candida-infected mice renal cells.
Candidiasis
Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes.
Candidiasis
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects.
Candidiasis
Competitive binding inhibition enzyme-linked immunosorbent assay that uses the secreted aspartyl proteinase of Candida albicans as an antigenic marker for diagnosis of disseminated candidiasis.
Candidiasis
Correction: Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis.
Candidiasis
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.
Candidiasis
Differential secretion of Sap4-6 proteins in Candida albicans during hyphae formation.
Candidiasis
Expression of Candida albicans secreted aspartyl proteinase in acute vaginal candidiasis.
Candidiasis
Hydrolytic gene expression during oroesophageal and gastric candidiasis in immunocompetent and immunodeficient gnotobiotic mice.
Candidiasis
IL-1alpha, IL-1ra and IL-8 are differentially induced by Candida in experimental oral candidiasis.
Candidiasis
In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.
Candidiasis
Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis.
Candidiasis
Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice.
Candidiasis
Production of hybrid phage displaying secreted aspartyl proteinase epitope of Candida albicans and its application for the diagnosis of disseminated candidiasis.
Candidiasis
Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2.
Candidiasis
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis.
Candidiasis
Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans.
Candidiasis
Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.
Candidiasis
Silver-loaded graphene as an effective SERS substrate for clotrimazole detection: DFT and spectroscopic studies.
Candidiasis
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.
Candidiasis
Vaccination with Secreted Aspartyl Proteinase 2 Protein from Candida parapsilosis Can Enhance Survival of Mice during C. tropicalis-Mediated Systemic Candidiasis.
Candidiasis, Invasive
Use of monoclonal antibody in diagnosis of candidiasis caused by Candida albicans: detection of circulating aspartyl proteinase antigen.
Candidiasis, Oral
Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition.
Candidiasis, Oral
Enzymatic activity profile of a Brazilian culture collection of Candida albicans isolated from diabetics and non-diabetics with oral candidiasis.
Candidiasis, Oral
In vitro evaluation of the enzymatic activity profile of non-albicans Candida species isolated from patients with oral candidiasis with or without diabetes.
Candidiasis, Oral
In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.
Candidiasis, Oral
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients.
Candidiasis, Oral
Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis.
Candidiasis, Vulvovaginal
Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis.
Candidiasis, Vulvovaginal
Virulence of "white-gray-opaque" tri-stable transformation in clinical Candida albicans in vitro and in vivo.
Carcinoma
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Cholera
Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis.
Coccidioidomycosis
A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice.
Coinfection
Analysis of heavy-chain antibody responses and resistance to Parelaphostrongylus tenuis in experimentally infected alpacas.
Coinfection
Streptococcus oralis and Candida albicans Synergistically Activate ?-Calpain to Degrade E-cadherin From Oral Epithelial Junctions.
Colorectal Neoplasms
Blockade of gamma-secretase activity within the hippocampus enhances long-term memory.
Decompression Sickness
Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombe and causes polar replication fork arrest.
Hepatitis B
Biosynthesis of hepatitis B virus e antigen: directed mutagenesis of the putative aspartyl protease site.
Herpes Simplex
Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation.
HIV Infections
Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders.
HIV Infections
[In vitro study of oral Candida albicans in virulence from HIV-positive individuals]
Hypersensitivity
Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.
Hypertension
Development of inhibitors of the aspartyl protease renin for the treatment of hypertension.
Hypertension
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
Hypertension
Exploring the pH-Dependent Structure-Dynamics-Function Relationship of Human Renin.
Hypertension
Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
Hypertension
Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
Hypertension
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker.
Infections
An effector of apple proliferation phytoplasma targets TCP transcription factors - a generalized virulence strategy of phytoplasma?
Infections
Antibody to the Dirofilaria immitis aspartyl protease inhibitor homologue is a diagnostic marker for feline heartworm infections.
Infections
Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii.
Infections
Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis.
Infections
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.
Infections
Effect of HIV aspartyl protease inhibitors on experimental infection with a cystogenic Me49 strain of Toxoplasma gondii.
Infections
Expression of Candida albicans secreted aspartyl proteinase in acute vaginal candidiasis.
Infections
Gene expression of Paracoccidioides virulence factors after interaction with macrophages and fibroblasts.
Infections
Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection.
Infections
Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.
Infections
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis.
Infections
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells.
Infections
Inhibition of secreted aspartyl proteinase activity in biofilms of Candida species by mycogenic silver nanoparticles.
Infections
Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study.
Infections
Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice.
Infections
Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.
Infections
Quantitative expression of Candida albicans aspartyl proteinase genes SAP7, SAP8, SAP9, SAP10 in human serum in vitro.
Infections
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis.
Infections
Relationship between Sap prevalence and biofilm formation among resistant clinical isolates of Candida albicans.
Infections
Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.
Infections
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Infections
The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors.
Infections
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.
Infections
Upregulation of secreted aspartyl proteinase genes of fluconazole-sensitive Candida albicans isolates.
Infections
Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.
Insulin Resistance
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
Intestinal Volvulus
Antibody to the Dirofilaria immitis aspartyl protease inhibitor homologue is a diagnostic marker for feline heartworm infections.
Leukoplakia
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Lipodystrophy
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
Lung Injury
Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.
Malaria
Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.
Malaria
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.
Malaria
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Melanoma
Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.
Mycoses
Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study.
Mycoses
Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections.
Mycoses
The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.
Nematode Infections
Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis.
Neoplasm Metastasis
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Neoplasm Metastasis
Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts.
Neoplasm Metastasis
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Neoplasm Metastasis
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Neoplasms
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
Neoplasms
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Neoplasms
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Neoplasms
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density.
Neoplasms
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Neoplasms
Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of {gamma}-Secretase.
Neoplasms
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Neoplasms
Moloney murine leukemia virus protease: bacterial expression and characterization of the purified enzyme.
Neoplasms
Muscle aspartyl protease (cathepsin D) activity: detection using a chromophoric substrate and relation to wasting in DBA/2 mice implanted with leukemic L1210 tumor cells.
Neoplasms
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Neoplasms
Non-canonical Shedding of TNF? by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.
Neoplasms
Phospholipase and proteinase activities of clinical isolates of Candida from immunocompromised patients.
Neoplasms
Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.
Neoplasms
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Neoplasms
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
Neoplasms
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects.
Neurodegenerative Diseases
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Neurodegenerative Diseases
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
Opportunistic Infections
In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.
Osteoarthritis
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Ovarian Neoplasms
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
Paracoccidioidomycosis
Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.
Phytoplasma Disease
Alterations of plant architecture and phase transition by the phytoplasma virulence factor SAP11.
Phytoplasma Disease
The small phytoplasma virulence effector SAP11 contains distinct domains required for nuclear targeting and CIN-TCP binding and destabilization.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Retinal Degeneration
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Squamous Cell Carcinoma of Head and Neck
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Starvation
Characterization of a gene from the filamentous fungus Podospora anserina encoding an aspartyl protease induced upon carbon starvation.
Starvation
Transgenic plants that express the phytoplasma effector SAP11 show altered phosphate starvation and defense responses.
Stomatitis, Denture
Expression of Secreted Aspartyl Proteinases in an Experimental Model of Candida albicans-Associated Denture Stomatitis.
Uterine Cervical Neoplasms
HIV-1 Protease Inhibitors Slow HPV16-Driven Cell Proliferation through Targeted Depletion of Viral E6 and E7 Oncoproteins.
Vaginitis
Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.
Vaginitis
High aspartyl proteinase production and vaginitis in human immunodeficiency virus-infected women.
Vaginitis
Overexpression of Candida albicans Secreted Aspartyl Proteinases 2 or 5 is not sufficient for exacerbation of immunopathology in a murine model of vaginitis.
Wasting Syndrome
Muscle aspartyl protease (cathepsin D) activity: detection using a chromophoric substrate and relation to wasting in DBA/2 mice implanted with leukemic L1210 tumor cells.
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