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Disease on EC 3.4.23.24 - Candidapepsin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection.
Enhanced extracellular production of aspartyl proteinase, a virulence factor, by Candida albicans isolates following growth in subinhibitory concentrations of fluconazole.
In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.
Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.
Syntheses of FDA Approved HIV Protease Inhibitors.
The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus.
[Highly Active AntiRetroviral Therapy and cryptosporidiosis]
Adenocarcinoma
Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.
Alzheimer Disease
A G-Rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing.
A molecular dynamics study of the BACE1 conformational change from Apo to closed form induced by hydroxyethylamine derived compounds.
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
A peptide binding to the ?-site of APP improves spatial memory and attenuates A? burden in Alzheimer's disease transgenic mice.
A?42 oligomers modulate ?-secretase through an XBP-1s-dependent pathway involving HRD1.
Acylguanidines as small-molecule beta-secretase inhibitors.
APH-1A Component of ?-Secretase Forms an Internal Water and Ion-Containing Cavity.
Application of a Bioinformatics-Based Approach to Identify Novel Putative in vivo BACE1 Substrates.
Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease.
Assigning the protonation states of the key aspartates in beta-Secretase using QM/MM X-ray structure refinement.
BACE (beta-secretase) modulates the processing of APLP2 in vivo.
BACE inhibitors as potential therapeutics for Alzheimer's disease.
BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
BACE1 in Alzheimer's disease.
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.
BACE: Therapeutic target and potential biomarker for Alzheimer's disease.
Calcium enhances the proteolytic activity of BACE1: An in vitro biophysical and biochemical characterization of the BACE1-calcium interaction.
Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene.
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.
Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible lead for Alzheimer's Disease.
Designed Helical Peptides as Functional Probes for ?-Secretase.
Determination of the active site protonation state of beta-secretase from molecular dynamics simulation and docking experiment: implications for structure-based inhibitor design.
Determination of the protonation state for the catalytic dyad in ?-secretase when bound to hydroxyethylamine transition state analogue inhibitors: A molecular dynamics simulation study.
Development of a specific ELISA to measure BACE1 levels in human tissues.
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of ?-Secretase (BACE1) through Fragment-Based Drug Design.
Discovery of AM-6494: A Potent and Orally Efficacious ?-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2.
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of {gamma}-Secretase.
Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage.
Evidence for dimeric BACE-mediated APP processing.
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.
Familial Alzheimer's disease presenilin 1 mutation M146V increases gamma secretase cutting of p75NTR in vitro.
Fragment-Based Discovery of Nonpeptidic BACE-1 Inhibitors Using Tethering.
Gadd153 and NF-?B Crosstalk Regulates 27-Hydroxycholesterol-Induced Increase in BACE1 and ?-Amyloid Production in Human Neuroblastoma SH-SY5Y Cells.
Gene structure and organization of the human beta-secretase (BACE) promoter.
Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.
Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing.
Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.
In vivo Reconstitution of {gamma}-Secretase in Drosophila Results in Substrate Specificity.
Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.
Interaction between the APOE epsilon4 allele and the APH-1b c + 651T > G SNP in Alzheimer's disease.
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.
Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains.
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Large scale refolding and purification of the catalytic domain of human BACE-2 produced in E. coli.
Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments.
Leptin attenuates BACE1 expression and amyloid-? genesis via the activation of SIRT1 signaling pathway.
Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
Modeling the protonation states of ?-secretase binding pocket by molecular dynamics simulations and docking studies.
Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities.
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.
pH-dependent conformational dynamics of beta-secretase 1: A molecular dynamics study.
Phosphorylation regulates intracellular trafficking of beta-secretase.
Population density analysis for determining the protonation state of the catalytic dyad in BACE1-tertiary carbinamine-based inhibitor complex.
Prediction of the tertiary structure of the beta-secretase zymogen.
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
Reconstitution of gamma-secretase activity.
Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system.
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.
Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects.
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.
Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteases.
Structure-guided design of ?-secretase (BACE-1) inhibitors.
Successive cleavage of ?-amyloid precursor protein by ?-secretase.
Synaptic Autoregulation by Metalloproteases and {gamma}-Secretase.
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
The genetic association between Cathepsin D and Alzheimer's disease.
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve.
The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and Beyond.
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects.
Toward the structure of presenilin/?-secretase and presenilin homologs.
Translational control of BACE1 may go awry in Alzheimer's disease.
Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells.
Breast Neoplasms
Biological and clinical significance of cathepsin D in breast cancer.
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Cathepsin D in primary breast carcinoma: adverse prognosis is associated with expression of cathepsin D in stromal cells.
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Characterization of purified cathepsin D from malignant human breast tissue.
Clinical significance of pepsinogen C tumor expression in patients with stage D2 prostate carcinoma.
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Low cathepsin D and low plasminogen activator type 1 inhibitor in tumor cytosols defines a group of node negative breast cancer patients with low risk of recurrence.
Mitogenic activity toward human breast cancer cell line MCF-7 of two bFGFs purified from sera of breast cancer patients: co-operative role of cathepsin D.
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner.
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
The role of cathepsin D in the invasiveness of human breast cancer cells.
Candidiasis
A modified in situ RT-PCR method for localizing fungal-specific gene expression in Candida-infected mice renal cells.
Analysis of secreted aspartic proteinases from Candida albicans: purification and characterization of individual Sap1, Sap2 and Sap3 isoenzymes.
Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects.
Competitive binding inhibition enzyme-linked immunosorbent assay that uses the secreted aspartyl proteinase of Candida albicans as an antigenic marker for diagnosis of disseminated candidiasis.
Correction: Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis.
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.
Differential secretion of Sap4-6 proteins in Candida albicans during hyphae formation.
Engineering Candida albicans to secrete a host immunomodulatory factor.
Expression of Candida albicans secreted aspartyl proteinase in acute vaginal candidiasis.
Hydrolytic gene expression during oroesophageal and gastric candidiasis in immunocompetent and immunodeficient gnotobiotic mice.
IL-1alpha, IL-1ra and IL-8 are differentially induced by Candida in experimental oral candidiasis.
In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.
Limited role of secreted aspartyl proteinases Sap1 to Sap6 in Candida albicans virulence and host immune response in murine hematogenously disseminated candidiasis.
Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice.
Production of hybrid phage displaying secreted aspartyl proteinase epitope of Candida albicans and its application for the diagnosis of disseminated candidiasis.
Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2.
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis.
Sap6, a secreted aspartyl proteinase, participates in maintenance the cell surface integrity of Candida albicans.
Secreted aspartic protease cleavage of Candida albicans Msb2 activates Cek1 MAPK signaling affecting biofilm formation and oropharyngeal candidiasis.
Silver-loaded graphene as an effective SERS substrate for clotrimazole detection: DFT and spectroscopic studies.
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.
Vaccination with Secreted Aspartyl Proteinase 2 Protein from Candida parapsilosis Can Enhance Survival of Mice during C. tropicalis-Mediated Systemic Candidiasis.
Candidiasis, Invasive
Use of monoclonal antibody in diagnosis of candidiasis caused by Candida albicans: detection of circulating aspartyl proteinase antigen.
Candidiasis, Oral
Candida albicans Sap6 amyloid regions function in cellular aggregation and zinc binding, and contribute to zinc acquisition.
Enzymatic activity profile of a Brazilian culture collection of Candida albicans isolated from diabetics and non-diabetics with oral candidiasis.
In vitro evaluation of the enzymatic activity profile of non-albicans Candida species isolated from patients with oral candidiasis with or without diabetes.
In vivo analysis of secreted aspartyl proteinase expression in human oral candidiasis.
In vivo expression and localization of Candida albicans secreted aspartyl proteinases during oral candidiasis in HIV-infected patients.
Novel Aggregation Properties of Candida albicans Secreted Aspartyl Proteinase Sap6 Mediate Virulence in Oral Candidiasis.
Candidiasis, Vulvovaginal
Differential expression of Candida albicans secreted aspartyl proteinase in human vulvovaginal candidiasis.
Studies of Immune Responses in Candida vaginitis.
Virulence of "white-gray-opaque" tri-stable transformation in clinical Candida albicans in vitro and in vivo.
Carcinoma
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Cholera
Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis.
Coccidioidomycosis
A recombinant aspartyl protease of Coccidioides posadasii induces protection against pulmonary coccidioidomycosis in mice.
Coinfection
Analysis of heavy-chain antibody responses and resistance to Parelaphostrongylus tenuis in experimentally infected alpacas.
Streptococcus oralis and Candida albicans Synergistically Activate ?-Calpain to Degrade E-cadherin From Oral Epithelial Junctions.
Colorectal Neoplasms
Blockade of gamma-secretase activity within the hippocampus enhances long-term memory.
Decompression Sickness
Sap1p binds to Ter1 at the ribosomal DNA of Schizosaccharomyces pombe and causes polar replication fork arrest.
Enteritis
[Highly Active AntiRetroviral Therapy and cryptosporidiosis]
Hepatitis B
Biosynthesis of hepatitis B virus e antigen: directed mutagenesis of the putative aspartyl protease site.
Herpes Simplex
Nelfinavir impairs glycosylation of herpes simplex virus 1 envelope proteins and blocks virus maturation.
HIV Infections
Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders.
[In vitro study of oral Candida albicans in virulence from HIV-positive individuals]
Hypersensitivity
Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae.
Hypertension
Development of inhibitors of the aspartyl protease renin for the treatment of hypertension.
Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors.
Exploring the pH-Dependent Structure-Dynamics-Function Relationship of Human Renin.
Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.
Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors.
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: Prime site exploration using an oxygen linker.
Infections
An effector of apple proliferation phytoplasma targets TCP transcription factors - a generalized virulence strategy of phytoplasma?
Antibody to the Dirofilaria immitis aspartyl protease inhibitor homologue is a diagnostic marker for feline heartworm infections.
Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii.
Candida albicans-secreted aspartic proteinases modify the epithelial cytokine response in an in vitro model of vaginal candidiasis.
Cleavage of human big endothelin-1 by Candida albicans aspartic proteinase.
Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections.
Effect of HIV aspartyl protease inhibitors on experimental infection with a cystogenic Me49 strain of Toxoplasma gondii.
Expression of Candida albicans secreted aspartyl proteinase in acute vaginal candidiasis.
Extracellular proteinases of Candida species pathogenic yeasts.
Gene expression of Paracoccidioides virulence factors after interaction with macrophages and fibroblasts.
Genetically Engineered Virus Nanofibers as an Efficient Vaccine for Preventing Fungal Infection.
Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions.
Hyphal invasion of Candida albicans inhibits the expression of human beta-defensins in experimental oral candidiasis.
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells.
Inhibition of secreted aspartyl proteinase activity in biofilms of Candida species by mycogenic silver nanoparticles.
Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study.
Overexpression of Candida albicans secretory aspartyl proteinase 2 and its expression in Saccharomyces cerevisiae do not augment virulence in mice.
Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection.
Quantitative expression of Candida albicans aspartyl proteinase genes SAP7, SAP8, SAP9, SAP10 in human serum in vitro.
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis.
Relationship between Sap prevalence and biofilm formation among resistant clinical isolates of Candida albicans.
Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
The crystal structure of a major secreted aspartic proteinase from Candida albicans in complexes with two inhibitors.
The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.
Upregulation of secreted aspartyl proteinase genes of fluconazole-sensitive Candida albicans isolates.
Wild-type Drosophila melanogaster as a model host to analyze nitrogen source dependent virulence of Candida albicans.
Insulin Resistance
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
Intestinal Volvulus
Antibody to the Dirofilaria immitis aspartyl protease inhibitor homologue is a diagnostic marker for feline heartworm infections.
Keratitis
The role of secreted aspartyl proteinases in Candida albicans keratitis.
Leukoplakia
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Lipodystrophy
Diarrhea-associated HIV-1 APIs potentiate muscarinic activation of Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling.
Lung Injury
Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.
Malaria
An aspartyl protease directs malaria effector proteins to the host cell.
Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P2 position of PEXEL peptidomimetics.
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial library.
Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.
Targeting Plasmodium Plasmepsin V: Hitting Two Birds with One Stone.
Melanoma
Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.
Mycoses
Insights into the selective inhibition of Candida albicans secreted aspartyl protease: a docking analysis study.
Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections.
The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.
Nematode Infections
Identification and characterisation of an aspartyl protease inhibitor homologue as a major allergen of Trichostrongylus colubriformis.
Neoplasm Metastasis
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts.
Prognostic indicators for early-stage breast-carcinoma .2. Value of cathepsin-d expression, detected by immunocytochemistry - a multiparametric study.
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Neoplasms
?-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors.
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies.
Cathepsin D concentration in breast cancer cytosols: correlation with disease-free interval and overall survival.
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells.
Cathepsin D in ovarian cancer: prognostic value and correlation with p53 expression and microvessel density.
Cathepsin D is a potential serum marker for poor prognosis in glioma patients.
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment.
Characterization of purified cathepsin D from malignant human breast tissue.
Epidermal Growth Factor Receptor and Notch Pathways Participate in the Tumor Suppressor Function of {gamma}-Secretase.
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Immunohistochemical detection of cathepsin-d expression in prostate-cancer.
Moloney murine leukemia virus protease: bacterial expression and characterization of the purified enzyme.
Muscle aspartyl protease (cathepsin D) activity: detection using a chromophoric substrate and relation to wasting in DBA/2 mice implanted with leukemic L1210 tumor cells.
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Nm23 and cathepsin D expression in laryngeal carcinomas.
Non-canonical Shedding of TNF? by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix.
Phospholipase and proteinase activities of clinical isolates of Candida from immunocompromised patients.
Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.
Quantitative immunohistochemical determination of cathepsin D levels in prostatic carcinoma biopsies. Correlation with tumor grade, stage, PSA level, and DNA ploidy status.
Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion.
The potential prognostic value of cathepsin D protein in serous ovarian cancer.
Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects.
Neurodegenerative Diseases
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
Structure-guided design of ?-secretase (BACE-1) inhibitors.
Opportunistic Infections
In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors.
Osteoarthritis
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D.
Ovarian Neoplasms
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors.
Paracoccidioidomycosis
Secreted aspartyl proteinase (PbSap) contributes to the virulence of Paracoccidioides brasiliensis infection.
Phytoplasma Disease
Alterations of plant architecture and phase transition by the phytoplasma virulence factor SAP11.
The small phytoplasma virulence effector SAP11 contains distinct domains required for nuclear targeting and CIN-TCP binding and destabilization.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease.
Squamous Cell Carcinoma of Head and Neck
Spectrophotometric analysis of the expression of secreted aspartyl proteinases from Candida in leukoplakia and oral squamous cell carcinoma.
Starvation
Characterization of a gene from the filamentous fungus Podospora anserina encoding an aspartyl protease induced upon carbon starvation.
Transgenic plants that express the phytoplasma effector SAP11 show altered phosphate starvation and defense responses.
Stomatitis, Denture
Expression of Secreted Aspartyl Proteinases in an Experimental Model of Candida albicans-Associated Denture Stomatitis.
Uterine Cervical Neoplasms
HIV-1 Protease Inhibitors Slow HPV16-Driven Cell Proliferation through Targeted Depletion of Viral E6 and E7 Oncoproteins.
Vaginitis
Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis.
High aspartyl proteinase production and vaginitis in human immunodeficiency virus-infected women.
Overexpression of Candida albicans Secreted Aspartyl Proteinases 2 or 5 is not sufficient for exacerbation of immunopathology in a murine model of vaginitis.
Wasting Syndrome
Muscle aspartyl protease (cathepsin D) activity: detection using a chromophoric substrate and relation to wasting in DBA/2 mice implanted with leukemic L1210 tumor cells.