Reference on EC 3.4.23.15 - renin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Poe, M.; Wu, J.K.; Florance, J.R.; Rodkey, J.A.; Bennett, C.D.; Hoogsteen, K.
Purification and properties of renin and gamma-renin from the mouse submaxillary gland
J. Biol. Chem.
258
2209-2216
1983
Mus musculus
Figueiredo, A.F.S.; Takii, Y.; Tsuji, H.; Kato, K.; Inagami, T.
Rat kidney renin and cathepsin D: purification and comparison of properties
Biochemistry
22
5476-5481
1983
Rattus norvegicus
Liu, C.F.; Fehrentz, J.A.; Heitz, A.; LeNguyen, D.; Castro, B.; Heitz, F.; Carelli, C.; Galen, F.X.; Corval, P.
Synthesis, conformation, and antibody recognition of peptides built of the sequence of the flap of human renin
Tetrahedron
44
675-683
1988
Homo sapiens
-
Fehrentz, J.A.; Heitz, A.; Seyer, R.; Fulcrand, P.; Devilliers, R.; Castro, B.; Heitz, F.; Carelli, C.
Peptides mimicking the flap of human renin: Synthesis, conformation, and antibody recognition
Biochemistry
27
4071-4078
1988
Homo sapiens
Egan, D.A.; Grzegorczyk, V.; Tricarico, K.A.; Rueter, A.; Hollemann, W.H.; Marcotte, P.A.
Human placental chorionic renin: Production, purification and characterization
Biochim. Biophys. Acta
965
68-75
1988
Homo sapiens
Faust, P.L.; Chirgwin, J.M.; Kornfeld, S.
Renin, a secretory glycoprotein, acquires phosphomannosyl residues
J. Cell Biol.
105
1947-1955
1987
Xenopus laevis
Tong, L.; Pav, S.; Lamarre, D.; Pilote, L.; LaPlante, S.; Anderson, P.C.; Jung, G.
High resolution crystal structure of recombinant human renin in complex with polyhydroxymonoamide inhibitors
J. Mol. Biol.
250
211-222
1995
Homo sapiens
Shinagawa, T.; Do, Y.S.; Tam, H.; Hsueh, W.A.
Complete purification of human renal renin and sequence of the amino terminus
Biochem. Biophys. Res. Commun.
139
446-454
1986
Homo sapiens
Kim, S.J.; Hirose, S.; Murakami, K.
Purification of human plasma inactive renin by immunoaffinity chromatography on profragment-specific IgG
Biochim. Biophys. Acta
873
27-30
1986
Homo sapiens
Dealwis, C.G.; Frazao, C.; Badasso, M.; Cooper, J.B.; Tickle, I.J.; Driessen, H.; Blundell, T.L.; Murakami, K.; Miyazaki, H.; Sueiraz-Diaz, J.
X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a dexapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen
J. Mol. Biol.
236
342-360
1994
Mus musculus
Hemmings, A.M.; Foundling, S.I.; Sibanda, B.L.; Wood, S.P.; Pearl, L.H.; Blundell, T.
Energy calculations on aspartic proteinases: Human renin, endotiapepsin and its complex with an angiotensinogen fragment analogue, H-142
Biochem. Soc. Trans.
13
1036-1041
1985
Homo sapiens
Leckie, B.J.
Human renin inhibitors
Aspartic Proteinases and their Inhibitors, Proc. FEBS Adv. Course, Meeting Date 1984 (Kostka, V. , ed. ), de Gruyter, Berlin, New York
443-461
1985
Homo sapiens
-
Leckie, B.J.; Szelke, M.; Atrash, B.; Beattie, S.R.; Hallett, A.; Jones, D.M.; McIntyre, G.D.; Suerias, J.; Webb, D.J.
Human renin inhibitors
Biochem. Soc. Trans.
13
1029-1032
1985
Homo sapiens
Burt, D.W.; Beecroft, L.J.; Mullins, J.J.; Pioli, D.; George, H.; Brooks, J.; Walker, J.; Brammar, W.J.
Mouse renin gene structure, evolution and function
Aspartic Proteinases and their Inhibitors, Proc. FEBS Adv. Course, Meeting Date 1984 (Kostka, V. , ed. ), de Gruyter, Berlin, New York
355-377
1985
Mus musculus
-
Szelke, M.
Chemistry of renin inhibitors
Aspartic Proteinases and their Inhibitors, Proc. FEBS Adv. Course, Meeting Date 1984 (Kostka, V. , ed. ), de Gruyter, Berlin, New York
421-441
1985
Homo sapiens
-
Inagami, T.; Misono, K.; Chang, J.J.; Takii, Y.; Dykes, C.
Renin and general aspartyl proteases: Differences and similarities in structure and function
Aspartic Proteinases and their Inhibitors, Proc. FEBS Adv. Course, Meeting Date 1984 (Kostka, V. , ed. ), de Gruyter, Berlin, New York
318-337
1985
Homo sapiens
-
Inagami, T.; Misono, K.S.; Chang, J.J.; Takii, Y.
Biochemistry of renin
Biochem. Soc. Trans.
12
951-953
1984
Homo sapiens, Mus musculus
Tree, M.; Brown, J.J.; Leckie, B.J.; Lever, A.F.; Manthem, P.; Morton, J.J.; Robertson, J.I.; Szelke, M.; Webb, D.
The renin-angiotensin converting enzyme cascade
Biochem. Soc. Trans.
12
948-951
1984
Canis lupus familiaris, Equus caballus, Homo sapiens, Rattus norvegicus, Sus scrofa
-
Poe, M.; Bergstrom, A.R.; Wu, J.K.; Bennett, C.D.; Rodkey, J.A.; Hoogsteen, K.
Mouse submaxillary gland renin
J. Biol. Chem.
259
8358-8362
1984
Mus musculus
Ganong, W.F.
The brain renin-angiotensin system
Annu. Rev. Physiol.
46
17-31
1984
Homo sapiens, Rattus norvegicus
Inagami, T.; Chang, J.J.; Dykes, C.W.; Takii, Y.; Kisaragi, M.; Misono, K.S.
Renin: Structural features of active enzyme and inactive precursor
Fed. Proc.
42
2729-2734
1983
Mus musculus
Ho, S.C.; Izumi, H.; Michelakis, A.M.
The purification and characterization of multiple forms of mouse submaxillary gland renin
Biochim. Biophys. Acta
717
405-413
1982
Mus musculus
Misono, K.S.; Inagami, T.
Structure of mouse submaxillary gland renin
J. Biol. Chem.
257
7536-7540
1982
Mus musculus
Norman, J.A.; Hadjilambris, O.; Baska, R.; Sharp, D.Y.; Kumar, R.
Stable expression, secretion, and characterization of active human renin in mammalian cells
Mol. Pharmacol.
41
53-59
1991
Homo sapiens
Hirose, S.; Ohsawa, T.; Inagami, T.; Murakami, K.
Brain renin from bovine anterior pituitary
J. Biol. Chem.
257
6316-6321
1982
Bos taurus
Tokita, Y.; Oda, H.; Franco-Saenz, R.; Mulrow, P.J.
Role of the tissue renin-angiotensin system in the action of angiotensin-converting enzyme inhibitors
Proc. Soc. Exp. Biol. Med.
208
391-396
1995
Rattus norvegicus
Morton, J.P.; Surcouf, E.; Berthou, J.; Corvol, P.; Foote, S.
Crystallizaion of mouse submaxillary gland renin
J. Mol. Biol.
155
539-540
1982
Mus musculus
Slater, E.E.
Renin
Methods Enzymol.
80
427-442
1981
Homo sapiens, Mus musculus, Sus scrofa
Takii, Y.; Inagami, T.
Purification of a completely inactive renin from hog kidney and identification as renin zymogen
Biochem. Biophys. Res. Commun.
104
133-140
1982
Sus scrofa
Ueno, N.; Miyazaki, H.; Hirose, S.; Murakami, K.
A 56000-dalton renin-binding protein in hog kidney is an endogenous renin inhibitor
J. Biol. Chem.
256
12023-12027
1981
Sus scrofa
Slater, E.E.; Strout, H.V.
Pure human renin
J. Biol. Chem.
256
8164-8171
1981
Homo sapiens
Yokosawa, H.; Holladay, L.A.; Inagami, T.; Haas, E.; Murakami, K.
Human renal renin
J. Biol. Chem.
255
3498-3502
1980
Homo sapiens
Takaori, K.; Kim, S.; Fukamizu, A.; Sagara, M.; Hosoi, M.; Katsuki, M.; Murakami, K.; Yamamoto, K.
Biochemical characteristics of human renin expressed in transgenic mice
Clin. Sci.
84
21-29
1993
Homo sapiens
Sagnella, G.A.; Peart, W.S.
Studies on the isolation and properties of renin granules from the rat kidney cortex
Biochem. J.
182
301-309
1979
Rattus norvegicus
Geoghegan, K.F.; Lanzetti, A.J.; Ammirati, M.J.; Danley, D.E.; O'Connor, B.A.; Hobart, P.M.
Simple procedure for recovery of crystallizable human recombinant renin from mammalian cell-conditioned medium
Adv. Exp. Med. Biol.
306
379-381
1991
Homo sapiens
Phillips, M.I.; Weyhenmeyer, J.; Felix, D.; Ganten, D.; Hoffman, W.E.
Evidence for an endogenous brain renin-angiotensin system
Fed. Proc.
38
2260-2266
1979
Rattus norvegicus
Ito, T.; Devaux, C.; Gautray, J.P.; Menard, J.; Corvol, P.
Physicochemical properties of non-activated and activated renin from human amniotic fluid
Biochim. Biophys. Acta
569
202-210
1979
Homo sapiens
Galen, F.X.; Devaux, C.; Guyenne, T.; Menard, J.; Corvol, P.
Multiple forms of human renin
J. Biol. Chem.
254
4848-4855
1979
Homo sapiens
Matoba, T.; Murakami, K.; Inagami, T.
Rat renin: Purification and characterization
Biochim. Biophys. Acta
526
560-571
1978
Rattus norvegicus
Morris, B.J.
Properties of the activation by pepsin of inactive renin in human amniotic fluid
Biochim. Biophys. Acta
527
86-97
1978
Homo sapiens
Dworschack, R.T.; Printz, M.P.
Interaction of kidney renin with aryl-, isoalkyl-, and N-alkyl-substituted sepharose derivatives: Multiplicity of interaction sites
Biochemistry
17
2484-2489
1978
Oryctolagus cuniculus
Yamauchi, T.; Suzuki, F.; Takahashi, A.; Tsutsumi, I.; Hori, H.; Watanabe, T.; Ishizuka, Y.; Nakamura, Y.; Muakami, K.
Expression of rat renin in mammalian cells and its purification
Clin. Exp. Hypertens. A
14
377-392
1992
Rattus norvegicus
Skeggs, L.T.; Levine, M.; Lentz, K.E.; Kahn, J.R.; Dorer, F.E.
Next developments in our knowledge of the chemistry of renin
Fed. Proc.
36
1755-1759
1977
Oryctolagus cuniculus, Mus musculus, Sus scrofa
Corvol, P.; Menard, J.
Renin purification and cloning
Hypertension
18
252-255
1991
Sus scrofa
Devaux, C.; Mnard, J.; Sicard, P.; Corvol, P.
Partial characterization of hog renin purified by affinity chromatography
Eur. J. Biochem.
64
621-627
1976
Sus scrofa
Cohen, S.; Taylor, J.M.; Murakami, K.; Michelakis, A.M.; Inagami, T.
Isolation and characterization of renin-like enzymes from mouse submaxillary glands
Biochemistry
11
4286-4293
1972
Mus musculus
Newsome, H.H.
Purification of bovine renin
Biochim. Biophys. Acta
185
247-250
1969
Bos taurus
Campbell, D.J.; Valentijn, A.J.; Condron, R.
Purification and amino-terminal sequence of rat kidney renin: Evidence for a two-chain structure
J. Hypertens.
9
29-33
1991
Rattus norvegicus
Inagami, T.
Structure and function of renin
J. Hypertens.
7
S3-S7
1989
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Evans, D.B.; Cornette, J.C.; Sawyer, T.K.; Staples, D.J.; De Vaux, A.E.; Sharma, S.K.
Substrate specificity and inhibitor structure-activity relationships of recombinant human renin: Implications in the in vivo evaluation of renin inhibitors
Biotechnol. Appl. Biochem.
12
161-175
1990
Homo sapiens
Kataoka, K.; Kurokawa, N.; Sawada, M.; Iguchi, K.; Yanaihara, N.; Takahara, S.; Okuyama, A.; Yanaihara, C.
Comparative immunochemical characterization of prorenin/renin in human extrarenal tissues and plasma with use of two specific radioummunoassay systems
Biomed. Res.
16
371-380
1995
Homo sapiens
-
Valdenaire, O.; Breu, V.; Giller, T.; Bur, D.; Fischli, W.
Cloning and characterization of marmoset renin: Comparison with human renin
J. Cardiovasc. Pharmacol.
34
893-897
1999
Callithrix sp.
Vlahos, C.J.; Walls, J.D.; Berg, D.T.; Grinnel, B.W.
The purification and characterization of recombinant human renin expressed in the human kidney cell line 293
Biochem. Biophys. Res. Commun.
171
375-383
1990
Homo sapiens
Pilote, L.; McKercher, G.; Thibeault, D.; Lamarre, D.
Enzymatic characterization of purified recombinant human renin
Biochem. Cell Biol.
73
163-170
1995
Homo sapiens
Mathews, S.; Doebli, H.; Pruschy, M.; Bosser, R.; D'Arcy, A.; Oefner, C.; Zulauf, M.; Gentz, R.; Breu, V.; Matile, H.; Schlaeger, J.; Fischli, W.
Recombinant human renin produced in different expression systems: Biochemical properties and 3D structure
Protein Expr. Purif.
7
81-91
1996
Homo sapiens
Shenoy, U.; Cassis, L.
Characterization of renin activity in brown adipose tissue
Am. J. Physiol.
272
989-999
1997
Rattus norvegicus
-
Seo, S.; Landry, D.W.; Oliver, J.A.
Renin inhibits the vasorelaxation induced by nitroso albumin
Biochem. Biophys. Res. Commun.
250
94-98
1998
Sus scrofa
Imai, T.; Miyazaki, H.; Hirose, S.; Hori, H.; Hayashi, T.; Kageyema, R.; Ohkubo, H.; Nakanishi, S.; Murakami, K.
Cloning and sequence analysis of cDNA for human renin precursor
Proc. Natl. Acad. Sci. USA
80
7405
1983
Homo sapiens
Hosoi, M.; Kim, S.; Yamauchi, T.; Watanabe, T.; Murakami, K.; Suzuki, F.; Takahashi, A.; Nakamura, Y.; Yamamoto, K.
Similarity between physiochemical properties of recombinant rat prorenin and native inactive renin
Biochem. J.
275
727-731
1991
Rattus norvegicus
-
Sielecki, A.R.; Hayakawa, K.; Fujinaga, M.; Murphy, M.E.P.; Fraser, M.; Muir, S.K.; Carilli, C.T.; Lewicki, J.A.; Baxter, J.D.; James, M.N.G.
Structure of recombinant human renin, a target for carciovascular-active drugs, at 2.5 A resolution
Science
243
1346-1351
1989
Homo sapiens
Holzman, T.F.; Chung, C.C.; Edalji, R.; Egan, D.A.; Martin, M.; Gubbins, E.J.; Krafft, G.A.; Wang, G.T.; Thomas, A.M.; Rosenberg, S.H.; Hutchins, C.
Characterization of recombinant human renin: Kinetics, pH-stability, and peptidomimetic inhibitor binding
J. Protein Chem.
10
553-563
1991
Homo sapiens
Misono, K.; Chang, J.; Inagami, T.
Amino acid sequence of mouse submaxillary gland renin
Proc. Natl. Acad. Sci. USA
79
4858-4862
1982
Mus musculus
Epps, D.E.; Cheney, J.; Schostarez, H.; Sawyer, T.K.; Prairie, M.; Krueger, W.C.; Mandel, F.
Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin
J. Med. Chem.
33
2080-2086
1990
Homo sapiens
Andrade, A.Q.; Casarini, D.E.; Schor, N.; Boim, M.A.
Characterization of renin mRNA expression and enzyme activity in rat and mouse mesangial cells
Braz. J. Med. Biol. Res.
35
17-24
2002
Mus musculus, Rattus norvegicus
Lefevre, G.; Gauron, S.
Automated quantitative determination of the new renin inhibitor CGP 60536 by high-performance liquid chromatography
J. Chromatogr. B
738
129-136
2000
Homo sapiens
Mueller, P.J.; Sullivan, M.J.; Grindstaff, R.R.; Cunningham, J.T.; Hasser, E.M.
Regulation of plasma vasopressin and renin activity in conscious hindlimb-unloaded rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
291
R46-R52
2006
Rattus norvegicus
Vidotti, D.B.; Casarini, D.E.; Cristovam, P.C.; Leite, C.A.; Schor, N.; Boim, M.A.
High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells
Am. J. Physiol. Renal Physiol.
286
F1039-F1045
2004
Rattus norvegicus
Valencia, J.C.; Pacheco-Rodriguez, G.; Carmona, A.K.; Xavier, J.; Bruneval, P.; Riemenschneider, W.K.; Ikeda, Y.; Yu, Z.X.; Ferrans, V.J.; Moss, J.
Tissue-specific renin-angiotensin system in pulmonary lymphangioleiomyomatosis
Am. J. Respir. Cell Mol. Biol.
35
40-47
2006
Homo sapiens (Q8IYK8), Homo sapiens
Uddin, M.; Harris-Nelson, N.
Renin activity and angiotensin I concentration in genetically selective inbred line of hypertensive mice
Biochem. Biophys. Res. Commun.
316
842-844
2004
Mus musculus
Yuan, L.; Wu, J.; Aluko, R.E.; Ye, X.
Kinetics of renin inhibition by sodium houttuyfonate analogs
Biosci. Biotechnol. Biochem.
70
2275-2280
2006
Homo sapiens
Schwartz, G.L.; Turner, S.T.
Screening for primary aldosteronism in essential hypertension: diagnostic accuracy of the ratio of plasma aldosterone concentration to plasma renin activity
Clin. Chem.
51
386-394
2005
Homo sapiens
Unger, N.; Lopez Schmidt, I.; Pitt, C.; Walz, M.K.; Philipp, T.; Mann, K.; Petersenn, S.
Comparison of active renin concentration and plasma renin activity for the diagnosis of primary hyperaldosteronism in patients with an adrenal mass
Eur. J. Endocrinol.
150
517-523
2004
Homo sapiens
Elased, K.M.; Cool, D.R.; Morris, M.
Novel mass spectrometric methods for evaluation of plasma angiotensin converting enzyme 1 and renin activity
Hypertension
46
953-959
2005
Mus musculus
Nabi, A.H.; Kageshima, A.; Uddin, M.N.; Nakagawa, T.; Park, E.Y.; Suzuki, F.
Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system
Int. J. Mol. Med.
18
483-488
2006
Rattus norvegicus
Ferrari, P.; Shaw, S.G.; Nicod, J.; Saner, E.; Nussberger, J.
Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary aldosteronism
J. Hypertens.
22
377-381
2004
Homo sapiens
Cobankara, V.; Oztuerk, M.A.; Kiraz, S.; Ertenli, I.; Haznedaroglu, I.C.; Pay, S.; Calgueneri, M.
Renin and angiotensin-converting enzyme (ACE) as active components of the local synovial renin-angiotensin system in rheumatoid arthritis
Rheumatol. Int.
25
285-291
2005
Homo sapiens
Blumenfeld, J.D.
Plasma renin activity for predicting antihypertensive drug efficacy
Am. J. Hypertens.
21
5-6
2008
Homo sapiens
Velez, J.C.; Bland, A.M.; Arthur, J.M.; Raymond, J.R.; Janech, M.G.
Characterization of renin-angiotensin system enzyme activities in cultured mouse podocytes
Am. J. Physiol. Renal Physiol.
293
F398-F407
2007
Mus musculus
Sarver, R.W.; Peevers, J.; Cody, W.L.; Ciske, F.L.; Dyer, J.; Emerson, S.D.; Hagadorn, J.C.; Holsworth, D.D.; Jalaie, M.; Kaufman, M.; Mastronardi, M.; McConnell, P.; Powell, N.A.; Quin, J.; Van Huis, C.A.; Zhang, E.; Mochalkin, I.
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors
Anal. Biochem.
360
30-40
2007
Homo sapiens
Nakagawa, T.; Akaki, J.; Satou, R.; Takaya, M.; Iwata, H.; Katsurada, A.; Nishiuchi, K.; Ohmura, Y.; Suzuki, F.; Nakamura, Y.
The His-Pro-Phe motif of angiotensinogen is a crucial determinant of the substrate specificity of renin
Biol. Chem.
388
237-246
2007
Homo sapiens
Velloso, E.P.; Vieira, R.; Cabral, A.C.; Kalapothakis, E.; Santos, R.A.
Reduced plasma levels of angiotensin-(1-7) and renin activity in preeclamptic patients are associated with the angiotensin I- converting enzyme deletion/deletion genotype
Braz. J. Med. Biol. Res.
40
583-590
2007
Homo sapiens
Tsutamoto, T.; Sakai, H.; Tanaka, T.; Fujii, M.; Yamamoto, T.; Wada, A.; Ohnishi, M.; Horie, M.
Comparison of active renin concentration and plasma renin activity as a prognostic predictor in patients with heart failure
Circ. J.
71
915-921
2007
Homo sapiens
Nussberger, J.; Aubert, J.F.; Bouzourene, K.; Pellegrin, M.; Hayoz, D.; Mazzolai, L.
Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine
Hypertension
51
1306-1311
2008
Mus musculus
Gradman, A.H.; Kad, R.
Renin inhibition in hypertension
J. Am. Coll. Cardiol.
51
519-528
2008
Rattus norvegicus
Bukhtiyarov, Y.; Zecher, M.; Panemangalore, R.; Wu, Z.; Bruno, J.G.; Yuan, J.; Xu, Z.; Dillard, L.W.; McGeehan, G.M.; Harrison, R.K.; Scott, B.B.
Cloning, characterization and site-directed mutagenesis of canine renin
J. Biochem.
142
671-680
2007
Canis lupus familiaris (Q6DYE7), Canis lupus familiaris
Menard, J.; Guyene, T.T.; Peyrard, S.; Azizi, M.
Conformational changes in prorenin during renin inhibition in vitro and in vivo
J. Hypertens.
24
529-534
2006
Homo sapiens
Goeschke, R.; Stutz, S.; Rasetti, V.; Cohen, N.C.; Rahuel, J.; Rigollier, P.; Baum, H.P.; Forgiarini, P.; Schnell, C.R.; Wagner, T.; Gruetter, M.G.; Fuhrer, W.; Schilling, W.; Cumin, F.; Wood, J.M.; Maibaum, J.
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin
J. Med. Chem.
50
4818-4831
2007
Callithrix sp., Homo sapiens
Staessen, J.A.; Li, Y.; Richart, T.
Oral renin inhibitors
Lancet
368
1449-1456
2006
Homo sapiens
Whaley-Connell, A.; Habibi, J.; Cooper, S.A.; Demarco, V.G.; Hayden, M.R.; Stump, C.S.; Link, D.; Ferrario, C.M.; Sowers, J.R.
Effect of renin inhibition and AT1R blockade on myocardial remodeling in the transgenic Ren2 rat
Am. J. Physiol. Endocrinol. Metab.
295
E103-E109
2008
Mus musculus
Pazik, J.; Ostrowska, J.; Lewandowski, Z.; Mroz, A.; Perkowska-Ptasi?ska, A.; Baczkowska, T.; Durlik, M.
Renin-angiotensin-aldosterone system inhibitors and statins prolong graft survival in post-transplant glomerulonephritis
Ann. Transplant.
13
41-45
2008
Homo sapiens
Park, P.J.; Ahn, C.B.; Jeon, Y.J.; Je, J.Y.
Renin inhibition activity by chitooligosaccharides
Bioorg. Med. Chem. Lett.
18
2471-2474
2008
Homo sapiens
Takahashi, S.; Hori, K.; Shinbo, M.; Hiwatashi, K.; Gotoh, T.; Yamada, S.
Isolation of human renin inhibitor from soybean: soyasaponin I is the novel human renin inhibitor in soybean
Biosci. Biotechnol. Biochem.
72
3232-3236
2008
Homo sapiens
Vaidyanathan, S.; Bartlett, M.; Dieterich, H.A.; Yeh, C.M.; Antunes, A.; Howard, D.; Dole, W.P.
Pharmacokinetic interaction of the direct renin inhibitor aliskiren with furosemide and extended-release isosorbide-5-mononitrate in healthy subjects
Cardiovasc. Ther.
26
238-246
2008
Homo sapiens
Fisher, N.D.; Jan Danser, A.H.; Nussberger, J.; Dole, W.P.; Hollenberg, N.K.
Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
Circulation
117
3199-3205
2008
Homo sapiens
Hong, Y.; Dingemanse, J.; Mager, D.E.
Pharmacokinetic/pharmacodynamic modeling of renin biomarkers in subjects treated with the renin inhibitor aliskiren
Clin. Pharmacol. Ther.
84
136-143
2008
Homo sapiens
Lastra, G.; Habibi, J.; Whaley-Connell, A.T.; Manrique, C.; Hayden, M.R.; Rehmer, J.; Patel, K.; Ferrario, C.; Sowers, J.R.
Direct renin inhibition improves systemic insulin resistance and skeletal muscle glucose transport in a transgenic rodent model of tissue renin overexpression
Endocrinology
150
2561-2568
2009
Mus musculus
Sultana, A.; Nabi, A.H.; Biswas, K.B.; Takemoto, M.; Suzuki, F.
A peptide YY inhibits the human renin activity in a pH dependent manner
Front. Biosci.
14
3286-3291
2009
Homo sapiens
Kushiro, T.; Itakura, H.; Abo, Y.; Gotou, H.; Terao, S.; Keefe, D.L.
Long-term safety, tolerability, and antihypertensive efficacy of aliskiren, an oral direct renin inhibitor, in Japanese patients with hypertension
Hypertens. Res.
32
169-175
2009
Homo sapiens
Imanishi, T.; Tsujioka, H.; Ikejima, H.; Kuroi, A.; Takarada, S.; Kitabata, H.; Tanimoto, T.; Muragaki, Y.; Mochizuki, S.; Goto, M.; Yoshida, K.; Akasaka, T.
Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes
Hypertension
52
563-572
2008
Oryctolagus cuniculus
Ayalasomayajula, S.; Yeh, C.M.; Vaidyanathan, S.; Flannery, B.; Dieterich, H.A.; Howard, D.; Bedigian, M.P.; Dole, W.P.
Effects of aliskiren, a direct renin inhibitor, on cardiac repolarization and conduction in healthy subjects
J. Clin. Pharmacol.
48
799-811
2008
Homo sapiens
Bezencon, O.; Bur, D.; Weller, T.; Richard-Bildstein, S.; Remen, L.; Sifferlen, T.; Corminboeuf, O.; Grisostomi, C.; Boss, C.; Prade, L.; Delahaye, S.; Treiber, A.; Strickner, P.; Binkert, C.; Hess, P.; Steiner, B.; Fischli, W.
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors (dagger)
J. Med. Chem.
52
3689-3702
2009
Rattus norvegicus, Homo sapiens (P00797)
Dietz, R.; Dechend, R.; Yu, C.M.; Bheda, M.; Ford, J.; Prescott, M.F.; Keefe, D.L.
Effects of the direct renin inhibitor aliskiren and atenolol alone or in combination in patients with hypertension
J. Renin Angiotensin Aldosterone Syst.
9
163-175
2008
Homo sapiens
Garcia, P.; Schwenzer, S.; Slotta, J.E.; Scheuer, C.; Tami, A.E.; Holstein, J.H.; Histing, T.; Burkhardt, M.; Pohlemann, T.; Menger, M.D.
Inhibition of angiotensin-converting enzyme stimulates fracture healing and periosteal callus formation - role of a local renin-angiotensin system
Br. J. Pharmacol.
159
1672-1680
2010
Mus musculus
Riccioni, G.; Vitulano, N.; DOrazio, N.; Bellocci, F.
Aliskiren, the first approved renin inhibitor: Clinical application and safety in the treatment of hypertension
Adv. Ther.
26
700-710
2009
Homo sapiens
Ortiz-Capisano, M.C.; Liao, T.D.; Ortiz, P.A.; Beierwaltes, W.H.
Calcium-dependent phosphodiesterase 1C inhibits renin release from isolated juxtaglomerular cells
Am. J. Physiol. Regul. Integr. Comp. Physiol.
297
R1469-R1476
2009
Mus musculus
Gonzalez-Villalobos, R.A.; Satou, R.; Ohashi, N.; Semprun-Prieto, L.C.; Katsurada, A.; Kim, C.; Upchurch, G.M.; Prieto, M.C.; Kobori, H.; Navar, L.G.
Intrarenal mouse renin-angiotensin system during ANG II-induced hypertension and ACE inhibition
Am. J. Physiol. Renal Physiol.
298
F150-F157
2010
Mus musculus
Whaley-Connell, A.; Nistala, R.; Habibi, J.; Hayden, M.R.; Schneider, R.I.; Johnson, M.S.; Tilmon, R.; Rehmer, N.; Ferrario, C.M.; Sowers, J.R.
Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat
Am. J. Physiol. Renal Physiol.
298
F655-F661
2010
Rattus norvegicus
Israili, Z.H.; Velasco, M.; Bermudez, V.
Direct renin inhibitors as antihypertensive agents
Am. J. Ther.
17
237-254
2010
Homo sapiens
Takahashi, S.; Hori, K.; Hokari, M.; Gotoh, T.; Sugiyama, T.
Inhibition of human renin activity by saponins
Biomed. Res.
31
155-159
2010
Homo sapiens
Tice, C.M.; Xu, Z.; Yuan, J.; Simpson, R.D.; Cacatian, S.T.; Flaherty, P.T.; Zhao, W.; Guo, J.; Ishchenko, A.; Singh, S.B.; Wu, Z.; Scott, B.B.; Bukhtiyarov, Y.; Berbaum, J.; Mason, J.; Panemangalore, R.; Cappiello, M.G.; Mueller, D.; Harrison, R.K.; McGeehan, G.M.; Dillard, L.W.; Baldwin, J.J.; Claremon, D.A.
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines
Bioorg. Med. Chem. Lett.
19
3541-3545
2009
Homo sapiens (P00797)
Yamaguchi, Y.; Menear, K.; Cohen, N.C.; Mah, R.; Cumin, F.; Schnell, C.; Wood, J.M.; Maibaum, J.
The P1N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin
Bioorg. Med. Chem. Lett.
19
4863-4867
2009
Homo sapiens
Remen, L.; Bezencon, O.; Richard-Bildstein, S.; Bur, D.; Prade, L.; Corminboeuf, O.; Boss, C.; Grisostomi, C.; Sifferlen, T.; Strickner, P.; Hess, P.; Delahaye, S.; Treiber, A.; Weller, T.; Binkert, C.; Steiner, B.; Fischli, W.
New classes of potent and bioavailable human renin inhibitors
Bioorg. Med. Chem. Lett.
19
6762-6765
2009
Homo sapiens
Chen, A.; Bayly, C.; Bezencon, O.; Richard-Bildstein, S.; Dube, D.; Dube, L.; Gagne, S.; Gallant, M.; Gaudreault, M.; Grimm, E.; Houle, R.; Lacombe, P.; Laliberte, S.; Levesque, J.F.; Liu, S.; MacDonald, D.; Mackay, B.; Martin, D.; McKay, D.; Powell, D.; Remen, L.; Soisson, S.; Toulmond, S.
Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension
Bioorg. Med. Chem. Lett.
20
2204-2209
2010
Homo sapiens
Xu, Z.; Cacatian, S.; Yuan, J.; Simpson, R.D.; Jia, L.; Zhao, W.; Tice, C.M.; Flaherty, P.T.; Guo, J.; Ishchenko, A.; Singh, S.B.; Wu, Z.; McKeever, B.M.; Scott, B.B.; Bukhtiyarov, Y.; Berbaum, J.; Mason, J.; Panemangalore, R.; Cappiello, M.G.; Bentley, R.; Doe, C.P.; Harrison, R.K.; McGeehan, G.M.; Dillard, L.W.
Optimization of orally bioavailable alkyl amine renin inhibitors
Bioorg. Med. Chem. Lett.
20
694-699
2010
Homo sapiens
Burke, S.L.; Evans, R.G.; Head, G.A.
Effects of chronic sympatho-inhibition on reflex control of renal blood flow and plasma renin activity in renovascular hypertension
Br. J. Pharmacol.
159
438-448
2010
Oryctolagus cuniculus
Mende, C.W.
Application of direct renin inhibition to chronic kidney disease
Cardiovasc. Drugs Ther.
24
139-149
2010
Homo sapiens
Schmieder, R.E.; Philipp, T.; Guerediaga, J.; Gorostidi, M.; Smith, B.; Weissbach, N.; Maboudian, M.; Botha, J.; van Ingen, H.
Long-term antihypertensive efficacy and safety of the oral direct renin inhibitor aliskiren: a 12-month randomized, double-blind comparator trial with hydrochlorothiazide
Circulation
119
417-425
2009
Homo sapiens
Solomon, S.D.; Appelbaum, E.; Manning, W.J.; Verma, A.; Berglund, T.; Lukashevich, V.; Cherif Papst, C.; Smith, B.A.; Dahloef, B.; Dahloef, B.
Effect of the direct renin inhibitor aliskiren, the angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
Circulation
119
530-537
2009
Homo sapiens
Rademaker, M.T.; Charles, C.J.; Nicholls, M.G.; Richards, A.M.
Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure
Circulation
2
532-540
2009
Ovis aries
Puig, J.G.; Schunkert, H.; Taylor, A.A.; Boye, S.; Jin, J.; Keefe, D.L.
Evaluation of the dose--response relationship of aliskiren, a direct renin inhibitor, in an 8-week, multicenter, randomized, double-blind, parallel-group, placebo-controlled study in adult patients with stage 1 or 2 essential hypertension
Clin. Ther.
31
2839-2850
2009
Homo sapiens
Komers, R.
What is the role of renin inhibition in the treatment of diabetic kidney disease?
Curr. Diab. Rep.
9
447-452
2009
Homo sapiens
Pinto, R.; Gradman, A.H.
Direct renin inhibition: an update
Curr. Hypertens. Rep.
11
456-462
2009
Homo sapiens
Duesing, R.; Sellers, F.
ACE inhibitors, angiotensin receptor blockers and direct renin inhibitors in combination: a review of their role after the ONTARGET trial
Curr. Med. Res. Opin.
25
2287-2301
2009
Homo sapiens
Moutzouri, E.; Florentin, M.; Elisaf, M.S.; Mikhailidis, D.P.; Liberopoulos, E.N.
Aliskiren, a directrenin inhibitor, in clinical practice: a new approach in the treatment of hypertension
Curr. Vasc. Pharmacol.
8
344-362
2010
Homo sapiens
Tapaninen, T.; Neuvonen, P.J.; Niemi, M.
Rifampicin reduces the plasma concentrations and the renin-inhibiting effect of aliskiren
Eur. J. Clin. Pharmacol.
66
497-502
2010
Homo sapiens
Tapaninen, T.; Neuvonen, P.J.; Niemi, M.
Effect of ABCB1 haplotypes on the pharmacokinetics and renin-inhibiting effect of aliskiren
Eur. J. Clin. Pharmacol.
66
865-870
2010
Homo sapiens
Politi, A.; Durdagi, S.; Moutevelis-Minakakis, P.; Kokotos, G.; Papadopoulos, M.G.; Mavromoustakos, T.
Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases
Eur. J. Med. Chem.
44
3703-3711
2009
Homo sapiens
Morales-Suarez-Varela, M.M.; Mansego, M.L.; Martin-Escudero, J.C.; Llopis-Gonzalez, A.; Chaves, F.J.; Lopez-Izquierdo, R.; Frutos-Llanes, R.; Vicedo-Cabrera, A.M.
How ineffective hypertension control in subjects treated with angiotensin-converting enzyme inhibitors is related to polymorphisms in the renin-angiotensin-aldosterone system
Eur. J. Pharm. Sci.
39
380-386
2010
Homo sapiens
Danser, A.H.
The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor?
Hypertens. Res.
33
4-10
2010
Homo sapiens
Schneider, M.P.; Hua, T.A.; Boehm, M.; Wachtell, K.; Kjeldsen, S.E.; Schmieder, R.E.
Prevention of atrial fibrillation by renin-angiotensin system inhibition a meta-analysis
J. Am. Coll. Cardiol.
55
2299-2307
2010
Homo sapiens
Kher, V.
Renin inhibition - benefit beyond hypertension control
J. Assoc. Physicians India
57
518-20, 525
2009
Homo sapiens
Hannila-Handelberg, T.; Kontula, K.K.; Paukku, K.; Lehtonen, J.Y.; Virtamo, J.; Tikkanen, I.; Hiltunen, T.P.
Common genetic variations of the renin-angiotensin-aldosterone system and response to acute angiotensin I-converting enzyme inhibition in essential hypertension
J. Hypertens.
28
771-779
2010
Homo sapiens
Santos, C.F.; Akashi, A.E.; Dionisio, T.J.; Sipert, C.R.; Didier, D.N.; Greene, A.S.; Oliveira, S.H.; Pereira, H.J.; Becari, C.; Oliveira, E.B.; Salgado, M.C.
Characterization of a local renin-angiotensin system in rat gingival tissue
J. Periodontol.
80
130-139
2009
Rattus norvegicus
Doulton, T.W.; MacGregor, G.A.
Combination renin-angiotensin system blockade with the renin inhibitor aliskiren in hypertension
J. Renin Angiotensin Aldosterone Syst.
10
185-189
2009
Homo sapiens
Sever, P.S.; Gradman, A.H.; Azizi, M.
Managing cardiovascular and renal risk: the potential of direct renin inhibition
J. Renin Angiotensin Aldosterone Syst.
10
65-76
2009
Homo sapiens
Ferrario, C.M.
Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control
Life Sci.
86
289-299
2010
Homo sapiens
Mueller, A.; Schweizer, J.; Kirch, W.; Schindler, C.; Schindler, C.
[Current status of antihypertensive drug treatment in primary care practice at launch of the new renin inhibitor aliskiren (RASANT)]
Med. Klin.
105
155-162
2010
Homo sapiens
Hollenberg, N.K.
Direct renin inhibition and the kidney
Nat. Rev. Nephrol.
6
49-55
2010
Homo sapiens
Kiski, D.; Stepper, W.; Brand, E.; Breithardt, G.; Reinecke, H.
Impact of renin-angiotensin-aldosterone blockade by angiotensin-converting enzyme inhibitors or AT-1 blockers on frequency of contrast medium-induced nephropathy: a post-hoc analysis from the Dialysis-versus-Diuresis (DVD) trial
Nephrol. Dial. Transplant.
25
759-764
2010
Homo sapiens
Jing, S.; Kezhou, Y.; Hong, Z.; Qun, W.; Rong, W.
Effect of renin-angiotensin system inhibitors on prevention of peritoneal fibrosis in peritoneal dialysis patients
Nephrology
15
27-32
2010
Homo sapiens
Hanessian, S.; Guesne, S.; Chenard, E.
Total synthesis of "aliskiren": the first renin inhibitor in clinical practice for hypertension
Org. Lett.
12
1816-1819
2010
Homo sapiens
Udenigwe, C.; Li, H.; Aluko, R.
Quantitative structure-activity relationship modeling of renin-inhibiting dipeptides
Amino Acids
2011
1-8
2011
Homo sapiens
Wedatilake, Y.N.; Scanlon, M.J.; Barnes, S.C.
The clinical utility of two renin mass methods to detect primary hyperaldosteronism compared with renin activity
Ann. Clin. Biochem.
48
256-262
2011
Homo sapiens
Bystrom, C.E.; Salameh, W.; Reitz, R.; Clarke, N.J.
Plasma renin activity by LC-MS/MS: development of a prototypical clinical assay reveals a subpopulation of human plasma samples with substantial peptidase activity
Clin. Chem.
56
1561-1569
2010
Homo sapiens
Kondo, T.; Goto, R.; Sonoda, K.; Yasuda, T.; Ono, K.; Takaki, Y.; Yatsuda, R.; Miyamura, N.; Araki, E.
Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine, in hypertensive patients
Intern. Med.
49
637-643
2010
Homo sapiens
Yamashita, S.; Shibata, N.; Boku-Ikeda, A.; Abe, E.; Inayama, A.; Yamaguchi, T.; Higuma, A.; Inagaki, K.; Tsuyuzaki, T.; Iwamoto, S.; Ohno, S.; Yokogawa, T.; Nishikawa, K.; Biswas, K.B.; Nabi, A.H.; Nakagawa, T.; Suzuki, F.; Ebihara, A.
Escherichia coli-based production of recombinant ovine angiotensinogen and its characterization as a renin substrate
BMC Biotechnol.
16
33
2016
Homo sapiens
Armesto, P.; Cousin, X.; Salas-Leiton, E.; Asensio, E.; Manchado, M.; Infante, C.
Molecular characterization and transcriptional regulation of the renin-angiotensin system genes in Senegalese sole (Solea senegalensis Kaup, 1858) differential gene regulation by salinity
Comp. Biochem. Physiol. A
184
6-19
2015
Solea senegalensis
Girgih, A.T.; Nwachukwu, I.D.; Hasan, F.; Fagbemi, T.N.; Gill, T.; Aluko, R.E.
Kinetics of the inhibition of renin and angiotensin I-converting enzyme by cod (Gadus morhua) protein hydrolysates and their antihypertensive effects in spontaneously hypertensive rats
Food Nutr. Res.
59
29788
2015
Homo sapiens
Fu, Y.; Alashi, A.M.; Young, J.F.; Therkildsen, M.; Aluko, R.E.
Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin
Int. J. Biol. Macromol.
101
207-213
2017
Homo sapiens (P00797)
Riedel, J.; Badewien-Rentzsch, B.; Kohn, B.; Hoeke, L.; Einspanier, R.
Characterization of key genes of the renin-angiotensin system in mature feline adipocytes and during invitro adipogenesis
J. Anim. Physiol. Anim. Nutr. (Berl.)
100
1139-1148
2016
Felis catus
Yan, Y.; Zhou, A.; Carrell, R.W.; Read, R.J.
Structural basis for the specificity of renin-mediated angiotensinogen cleavage
J. Biol. Chem.
294
2353-2364
2019
Homo sapiens (P00797), Homo sapiens
Ribeiro, A.A.; Palomino, Z.; Lima, M.P.; Souza, L.E.; Ferreira, D.S.; Pesquero, J.B.; Irigoyen, M.C.; Pesquero, J.L.; Casarini, D.E.
Characterization of the renal renin-angiotensin system in transgenic mice that express rat tonin
J. Renin Angiotensin Aldosterone Syst.
16
947-955
2015
Mus musculus
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