Reference on EC 3.4.22.B79 - nsP2 protease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Strauss, E.G.; De Groot, R.J.; Levinson, R.; Strauss, J.H.
Identification of the active site residues in the nsP2 proteinase of Sindbis virus
Virology
191
932-940
1992
Sindbis virus
Garmashova, N.; Gorchakov, R.; Frolova, E.; Frolov, I.
Sindbis virus nonstructural protein nsP2 is cytotoxic and inhibits cellular transcription
J. Virol.
80
5686-5696
2006
Sindbis virus
Golubtsov, A.; Kaeaeriaeinen, L.; Caldentey, J.
Characterization of the cysteine protease domain of Semliki Forest virus replicase protein nsP2 by in vitro mutagenesis
FEBS Lett.
580
1502-1508
2006
Semliki forest virus
Atasheva, S.; Gorchakov, R.; English, R.; Frolov, I.; Frolova, E.
Development of Sindbis viruses encoding nsP2/GFP chimeric proteins and their application for studying nsP2 functioning
J. Virol.
81
5046-5057
2007
Sindbis virus
Russo, A.T.; White, M.A.; Watowich, S.J.
The crystal structure of the Venezuelan equine encephalitis alphavirus nsP2 protease
Structure
14
1449-1458
2006
Venezuelan equine encephalitis virus (P27282)
Gorchakov, R.; Frolova, E.; Sawicki, S.; Atasheva, S.; Sawicki, D.; Frolov, I.
A new role for ns polyprotein cleavage in Sindbis virus replication
J. Virol.
82
6218-6231
2008
Sindbis virus
Mayuri, L.; Geders, T.W.; Smith, J.L.; Kuhn, R.J.
Role for conserved residues of sindbis virus nonstructural protein 2 methyltransferase-like domain in regulation of minus-strand synthesis and development of cytopathic infection
J. Virol.
82
7284-7297
2008
Sindbis virus
Zhang, D.; Toezser, J.; Waugh, D.S.
Molecular cloning, overproduction, purification and biochemical characterization of the p39 nsp2 protease domains encoded by three alphaviruses
Protein Expr. Purif.
64
89-97
2009
Semliki forest virus, Sindbis virus, Venezuelan equine encephalitis virus (P27282), Venezuelan equine encephalitis virus
Yang, A.; Wei, L.; Zhao, W.; Xu, Y.; Rao, Z.
Expression, crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of nsp2 from avian infectious bronchitis virus
Acta Crystallogr. Sect. F
65
788-790
2009
infectious bronchitis virus
Zhu, W.Y.; Fu, S.H.; Wang, J.L.; He, Y.; Tang, Q.; Liang, G.D.
Effects of the nsP2-726 Pro mutation on infectivity and pathogenesis of Sindbis virus derived from a full-length infectious cDNA clone
Virus Res.
142
204-207
2009
Sindbis virus
Russo, A.T.; Malmstrom, R.D.; White, M.A.; Watowich, S.J.
Structural basis for substrate specificity of alphavirus nsP2 proteases
J. Mol. Graph. Model.
29
46-53
2010
Venezuelan equine encephalitis virus (P27282), Venezuelan equine encephalitis virus
Nguyen, P.; Yu, H.; Keller, P.
Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches
J. Mol. Graph. Model.
57
1-8
2015
Chikungunya virus (Q8JUX6), Chikungunya virus, Chikungunya virus S27 (Q8JUX6)
Singh, K.; Kirubakaran, P.; Nagarajan, S.; Sakkiah, S.; Muthusamy, K.; Velmurgan, D.; Jeyakanthan, J.
Homology modeling, molecular dynamics, e-pharmacophore mapping and docking study of Chikungunya virus nsP2 protease
J. Mol. Model.
18
39-51
2012
Chikungunya virus (Q8JUX6), Chikungunya virus, Chikungunya virus S27 (Q8JUX6)
Sun, Z.; Li, Y.; Ransburgh, R.; Snijder, E.J.; Fang, Y.
Nonstructural protein 2 of porcine reproductive and respiratory syndrome virus inhibits the antiviral function of interferon-stimulated gene 15
J. Virol.
86
3839-3850
2012
porcine reproductive and respiratory syndrome virus
Akhrymuk, I.; Kulemzin, S.V.; Frolova, E.I.
Evasion of the innate immune response: the Old World alphavirus nsP2 protein induces rapid degradation of Rpb1, a catalytic subunit of RNA polymerase II
J. Virol.
86
7180-7191
2012
Sindbis virus, Semliki forest virus (P08411), Chikungunya virus (Q8JUX6), Chikungunya virus
Kim, D.Y.; Atasheva, S.; Frolova, E.I.; Frolov, I.
Venezuelan equine encephalitis virus nsP2 protein regulates packaging of the viral genome into infectious virions
J. Virol.
87
4202-4213
2013
Venezuelan equine encephalitis virus
Shin, G.; Yost, S.A.; Miller, M.T.; Elrod, E.J.; Grakoui, A.; Marcotrigiano, J.
Structural and functional insights into alphavirus polyprotein processing and pathogenesis
Proc. Natl. Acad. Sci. USA
109
16534-16539
2012
Sindbis virus (P03317)
Bi, C.; Shao, Z.; Li, J.; Weng, C.
Identification of novel epitopes targeting non-structural protein 2 of PRRSV using monoclonal antibodies
Appl. Microbiol. Biotechnol.
103
2689-2699
2019
porcine reproductive and respiratory syndrome virus (A6NA54), porcine reproductive and respiratory syndrome virus
Hu, X.; Compton, J.R.; Leary, D.H.; Olson, M.A.; Lee, M.S.; Cheung, J.; Ye, W.; Ferrer, M.; Southall, N.; Jadhav, A.; Morazzani, E.M.; Glass, P.J.; Marugan, J.; Legler, P.M.
Kinetic, mutational, and structural studies of the Venezuelan equine encephalitis virus nonstructural protein 2 cysteine protease
Biochemistry
55
3007-3019
2016
Venezuelan equine encephalitis virus (P27282), Venezuelan equine encephalitis virus, Venezuelan equine encephalitis virus Trinidad donkey (P27282)
Compton, J.R.; Mickey, M.J.; Hu, X.; Marugan, J.J.; Legler, P.M.
Mutation of Asn-475 in the Venezuelan equine encephalitis virus nsP2 cysteine protease leads to a self-inhibited state
Biochemistry
56
6221-6230
2017
Venezuelan equine encephalitis virus (P27282), Venezuelan equine encephalitis virus Trinidad donkey (P27282)
Saisawang, C.; Kuadkitkan, A.; Smith, D.R.; Ubol, S.; Ketterman, A.J.
Glutathionylation of chikungunya nsP2 protein affects protease activity
Biochim. Biophys. Acta
1861
106-111
2017
Chikungunya virus
El-labbad, E.M.; Ismail, M.A.; Abou Ei Ella, D.A.; Ahmed, M.; Wang, F.; Barakat, K.H.; Abouzid, K.A.
Discovery of novel peptidomimetics as irreversible CHIKV NsP2 protease inhibitors using quantum mechanical-based ligand descriptors
Chem. Biol. Drug Des.
86
1518-1527
2015
Chikungunya virus (C8YZ72), Chikungunya virus, Chikungunya virus 899 (C8YZ72)
Ramakrishnan, C.; Kutumbarao, N.H.V.; Suhitha, S.; Velmurugan, D.
Structure-function relationship of Chikungunya nsP2 protease A comparative study with papain
Chem. Biol. Drug Des.
89
772-782
2017
Chikungunya virus (Q8JUX6), Chikungunya virus, Chikungunya virus S27-African prototype (Q8JUX6)
Narwal, M.; Singh, H.; Pratap, S.; Malik, A.; Kuhn, R.J.; Kumar, P.; Tomar, S.
Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site
Int. J. Biol. Macromol.
116
451-462
2018
Chikungunya virus (Q8JUX6), Chikungunya virus, Chikungunya virus S27-African prototype (Q8JUX6)
Hurst-Hess, K.R.; Kuo, L.; Masters, P.S.
Dissection of amino-terminal functional domains of murine coronavirus nonstructural protein 3
J. Virol.
89
6033-6047
2015
Murine coronavirus (P0C6X9), Murine coronavirus A59 (P0C6X9)
Ramphan, S.; Khongwichit, S.; Saisawang, C.; Kovanich, D.; Ketterman, A.J.; Ubol, S.; Auewarakul, P.; Roytrakul, S.; Smith, D.R.; Kuadkitkan, A.
Ubiquitin-conjugating enzyme E2 L3 is downregulated by the chikungunya virus nsP2 protease
Proteomics Clin. Appl.
12
e1700020
2018
Chikungunya virus (A0A0E3MZW7), Chikungunya virus
Saisawang, C.; Saitornuang, S.; Sillapee, P.; Ubol, S.; Smith, D.; Ketterman, A.
Chikungunya nsP2 protease is not a papain-like cysteine protease and the catalytic dyad cysteine is interchangeable with a proximal serine
Sci. Rep.
5
17125
2015
Chikungunya virus, Chikungunya virus ECSA E1:226V
Rausalu, K.; Utt, A.; Quirin, T.; Varghese, F.S.; Zusinaite, E.; Das, P.K.; Ahola, T.; Merits, A.
Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 proteases active site cysteine residue
Sci. Rep.
6
37124
2016
Chikungunya virus (Q1W368), Chikungunya virus ECSA (Q1W368)
Saha, A.; Acharya, B.; Priya, R.; Tripathi, N.; Shrivastava, A.; Rao, M.; Kesari, P.; Narwal, M.; Tomar, S.; Bhagyawant, S.; Parida, M.; Dash, P.
Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus
Sci. Rep.
8
10831
2018
Chikungunya virus (C7S7A0), Chikungunya virus
Campos-Gomez, J.; Ahmad, F.; Rodriguez, E.; Saeed, M.F.
A novel cell-based assay to measure activity of Venezuelan equine encephalitis virus nsP2 protease
Virology
496
77-89
2016
Venezuelan equine encephalitis virus (Q9WJC7), Venezuelan equine encephalitis virus, Venezuelan equine encephalitis virus Mena II (Q9WJC7)
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