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(SUMO-1)-Mdm2 conjugate + H2O
SUMO + Mdm2
(SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-1 + Ran GTPase-activating protein 1
-
-
-
?
(SUMO-2)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-2 + Ran GTPase-activating protein 1
-
-
-
?
(SUMO-2/3)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-2/3 + Ran GTPase-activating protein 1
-
-
-
?
(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-3 + Ran GTPase-activating protein 1
-
-
-
?
acetyl-QTGG-7-amino-4-trifluoromethylcoumarin + H2O
acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin
-
-
-
-
?
diSUMO2 + H2O
2 SUMO2
-
-
-
?
poly-SUMO-2/3-Aurora-B conjugate + H2O
?
polySUMO2 + H2O
?
-
-
-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
SUMO-C/EBPbeta + H2O
SUMO + C/EBPbeta
SUMO-Mdm2 conjugate + H2O
SUMO + Mdm2
SUMO-Pc2/CBX4 conjugate + H2O
SUMO + Pc2/CBX4
SUMO-Ran GTPase-activating protein 1 conjugate + H2O
?
-
SENP2 exhibits substantially higher isopeptidase than endopeptidase activity
-
-
?
SUMOylated Mdm2 + H2O
?
Mdm2 controls p53 activities critical for G-S transition of mitotic division and endoreduplication in trophoblast proliferation and differentiation
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
SUMOylated Setdb1 + H2O
?
i.e. SET domain bifurcated 1, a histone methyltransferase for H3K9 trimethylation
-
-
?
SUMOylated Smad4 + H2O
?
Smad4 forms complexes with receptor-phosphorylated Smads, and transduces transforming growth factor-beta signals into the nuclei
-
-
?
SUMOylated TBL1/TBLR1 + H2O
?
i.e. transcriptional cofactor transducin beta-like
-
-
?
SUMOylated TGF-beta receptor + H2O
?
-
-
-
?
additional information
?
-
-
nucleoporin Nup153 binds to SENP2 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease
-
-
?
(SUMO-1)-Mdm2 conjugate + H2O
SUMO + Mdm2
-
-
-
-
?
(SUMO-1)-Mdm2 conjugate + H2O
SUMO + Mdm2
-
SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies. SENP2 catalyzes the desumoylation process of Mdm2. SENP2 mediated regulation of Mdm2 critical for genome integrity in p53-dependent stress responses
-
-
?
poly-SUMO-2/3-Aurora-B conjugate + H2O
?
-
specifically deconjugates SUMO from mitotic kinase Aurora-B. Lys202 on human Aurora-B is preferentially modified by SUMO, and enhancement of SUMOylation in cells facilitates Aurora-B autophosphorylation, which is essential for its activation. Conversely, SENP2-mediated deSUMOylation of Aurora-B down-regulates its autophosphorylation in cells and also impairs its re-activation in Aurora inhibitor VX-680-treated mitotic cells. Poly-SUMO-2 conjugation of Aurora-B occurs during the M phase ofthe cell cycle, and both SUMO-2 and PIAS3 are localized adjacent to Aurora-B in the kinetochores in early mitosis. Aurora-B is a mitotic SUMO substrate and its kinase activity is fine-tuned by the SUMO system
-
-
?
poly-SUMO-2/3-Aurora-B conjugate + H2O
?
-
specifically deconjugates SUMO from mitotic kinase Aurora-B. Lys-202 residue on human Aurora-B is preferentially modified by SUMO
-
-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
-
-
-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
50% of SUMO-1 precursor is hydrolyzed after 70 min
-
-
?
SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
-
very low isopeptidase activity with SUMO-1. SENP2 exhibits substantially higher isopeptidase than endopeptidase activity
-
-
?
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
-
-
-
?
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
50% of SUMO-2 precursor is hydrolyzed after 15 min
-
-
?
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
-
SENP2 exhibits substantially higher isopeptidase than endopeptidase activity
-
-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
-
-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
50% of SUMO-1 precursor is hydrolyzed after 160 min
-
-
?
SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
-
SENP2 exhibits substantially higher isopeptidase than endopeptidase activity
-
-
?
SUMO-C/EBPbeta + H2O
SUMO + C/EBPbeta
-
-
-
?
SUMO-C/EBPbeta + H2O
SUMO + C/EBPbeta
sumoylation causes destabilization of the C/EBPbeta protein and that this process can be reversed by SENP2
-
-
?
SUMO-Mdm2 conjugate + H2O
SUMO + Mdm2
-
Mdm2 is an important negative regulator of the p53 tumor suppressor. The SENP2 mediated SUMO modification of Mdm2 appears to be crucial for its subcellular trafficking
-
-
?
SUMO-Mdm2 conjugate + H2O
SUMO + Mdm2
-
Mdm2 is an important negative regulator of the p53 tumor suppressor
-
-
?
SUMO-Pc2/CBX4 conjugate + H2O
SUMO + Pc2/CBX4
Pc2/CBX4 is a polycomb repressive complex 1 (PRC1) subunit. SENP2 specifically controls Pc2/CBX4 contained PRC1 activity through regulation of the SUMOylation status of Pc2/CBX4, which facilitates its binding to H3K27me3 in mammalian cells to mediate transcriptional repression
-
-
?
SUMO-Pc2/CBX4 conjugate + H2O
SUMO + Pc2/CBX4
Pc2/CBX4 is a polycomb repressive complex 1 (PRC1) subunit
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
deSUMOylation by enzyme SENP2
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
deSUMOylation by enzyme SENP2
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
deSUMOylation by enzyme SENP2
-
-
?
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(SUMO-1)-Mdm2 conjugate + H2O
SUMO + Mdm2
-
SUMO conjugation of Mdm2 induces its co-localization and association with SENP2 at the PML bodies. SENP2 catalyzes the desumoylation process of Mdm2. SENP2 mediated regulation of Mdm2 critical for genome integrity in p53-dependent stress responses
-
-
?
poly-SUMO-2/3-Aurora-B conjugate + H2O
?
-
specifically deconjugates SUMO from mitotic kinase Aurora-B. Lys202 on human Aurora-B is preferentially modified by SUMO, and enhancement of SUMOylation in cells facilitates Aurora-B autophosphorylation, which is essential for its activation. Conversely, SENP2-mediated deSUMOylation of Aurora-B down-regulates its autophosphorylation in cells and also impairs its re-activation in Aurora inhibitor VX-680-treated mitotic cells. Poly-SUMO-2 conjugation of Aurora-B occurs during the M phase ofthe cell cycle, and both SUMO-2 and PIAS3 are localized adjacent to Aurora-B in the kinetochores in early mitosis. Aurora-B is a mitotic SUMO substrate and its kinase activity is fine-tuned by the SUMO system
-
-
?
SUMO-C/EBPbeta + H2O
SUMO + C/EBPbeta
sumoylation causes destabilization of the C/EBPbeta protein and that this process can be reversed by SENP2
-
-
?
SUMO-Mdm2 conjugate + H2O
SUMO + Mdm2
-
Mdm2 is an important negative regulator of the p53 tumor suppressor. The SENP2 mediated SUMO modification of Mdm2 appears to be crucial for its subcellular trafficking
-
-
?
SUMO-Pc2/CBX4 conjugate + H2O
SUMO + Pc2/CBX4
Pc2/CBX4 is a polycomb repressive complex 1 (PRC1) subunit. SENP2 specifically controls Pc2/CBX4 contained PRC1 activity through regulation of the SUMOylation status of Pc2/CBX4, which facilitates its binding to H3K27me3 in mammalian cells to mediate transcriptional repression
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
additional information
?
-
-
nucleoporin Nup153 binds to SENP2 by interacting with the unique N-terminal domain of Nup153 as well as a specific region within the C-terminal FG-rich region. Nup153 is a substrate for SUMOylation, with this modification kept in check by the SUMO protease
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
deSUMOylation by enzyme SENP2
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
deSUMOylation by enzyme SENP2
-
-
?
SUMOylated myocyte-specific enhancer factor-2A + H2O
deSUMOylated myocyte-specific enhancer factor-2A + SUMO
-
deSUMOylation by enzyme SENP2
-
-
?
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evolution
-
SUMO-specific protease 2 (SENP2) is a de-SUMOylation protease family member
evolution
the enzyme belongs to the SENP/ULP protease family
malfunction
in SENP2 null embryo, SUMOylated Pc2/CBX4 accumulates and Pc2/CBX4 occupancy on the promoters of PcG target genes is markedly increased, leading to repression of Gata4 and Gata6 transcription
malfunction
knockdown of SENP2 leads to a strong attenuation of adipogenesis with a marked decrease in PPARgamma and C/EBPalpha mRNA levels. Knockdown of SENP2 also causes a marked reduction in the level of C/EBPbeta protein but not in that of C/EBPbeta mRNA
malfunction
-
SENP2 ablation disturbs the p53-Mdm2 pathway, affecting the expansion of trophoblast progenitors and their maturation
malfunction
-
differential localization of nucleoporins upon codepletion of SENP1 and SENP2 in HeLa cells, immunohistochemic analysis, overview
malfunction
-
enzyme SENP2 knockout MEF cells show increased glucose uptake and lactate production along with decreased ATP levels. SENP2 knockout embryonic fibroblasts exhibit increased levels of phosphorylated AKT. Inhibiting AKT phosphorylation by LY294002 rescues the phenotype induced by SENP2 deficiency in embryonic fibroblasts. Knockout of SENP2 leads to increased aerobic glycolysis in MEF cells
malfunction
-
overexpression of enzyme SENP2 reduces the glucose uptake and lactate production, increasing the cellular ATP levels in MCF-7 cells. The MCF-7 cells overexpressing enzyme SENP2 exhibit decreased expression levels of key glycolytic enzymes and an increased rate of glucose oxidation compared with control MCF-7 cells, indicating inhibited glycolysis but enhanced oxidative mitochondrial respiration. The cells have a reduced amount of phosphorylated AKT
malfunction
RNA interference SENP2 knockdown produces no detectable phenotypes, while overexpression of SENP2, but not other SUMO-specific isopeptidases, causes a defect in chromosome congression that depends on its precise kinetochore targeting. Isozyme SENP2 overexpression uniquely induces prometaphase arrest
malfunction
-
silencing the expression of enzyme SENP2 significantly induces the expression of MMP13 , forced MMP13 expression is sufficient to restore cell invasion in SENP2 overexpressed T24 bladder cancer cells
malfunction
-
specifically, either RNAi depletion of SENP1/SENP2 or expression of dominantly interfering mutants of these proteins results in increased sumoylation of endogenous Nup153. Catalytically inactive SENP2 maintains specific attributes, although it has enhanced interaction with sumoylated Nup153, overview. Truncated SENP2CD is robustly modified by SUMO2
metabolism
-
SENP2 overexpression in MCF-7 cells reprograms glucose metabolism
metabolism
-
SENP2 protein is accumulated in response to activity-dependent stimuli which in turn mediated activity dependent-regulation of MEF2A deSUMOylation
physiological function
-
mitotic kinase Aurora-B is a mitotic SUMO substrate and its kinase activity is fine-tuned by the SUMO system
physiological function
-
SENP2 in mice reveals its essential role in development of all three trophoblast layers. SENP2 has a specific role in the G-S transition, which is required for mitotic and endoreduplication cell cycles in trophoblast proliferation and differentiation, respectively
physiological function
SENP2 plays a critical role in the control of adipogenesis by desumoylation and stabilization of C/EBPbeta and in turn by promoting the expression of its downstream effectors, such as PPARgamma and C/EBPalpha
physiological function
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. SENP2 specifically controls Pc2/CBX4 contained PRC1 activity through regulation of the SUMOylation status of Pc2/CBX4, which facilitates its binding to H3K27me3 in mammalian cells to mediate transcriptional repression
physiological function
enzyme SENP2 is an important mediator of precise spatial and temporal control of sumoylation in mitosis required for chromosome segregation
physiological function
-
enzyme SENP2 represses glycolysis and shifts glucose metabolic strategy, in part through inhibition of AKT phosphorylation, function of SENP2 in regulating glucose metabolism, overview
physiological function
-
enzyme SENP2 represses glycolysis and shifts glucose metabolic strategy, in part through inhibition of AKT phosphorylation, function of SENP2 in regulating glucose metabolism, overview
physiological function
-
nuclear factor-kappaB-mediated increase in the expression of SENP2 promotes the recruitment of peroxisome proliferator-activated receptors PPARdelta and PPARgamma, through deSUMOylation of PPARs, to the promoters of the genes involved in fatty acid oxidation, such as carnitine-palmitoyl transferase-1 and long-chain acyl-CoA synthetase 1. Enzyme overexpression substantially increases fatty acid oxidation in C2C12 myotubes
physiological function
-
SENP2, as well as SENP1, regulates the proper localization of nucleoporins, overview. The enzyme interacts with the nucleoporin Nup153 via a dual interface that includes a bridging interaction with the soluble transport receptor importin beta and a SUMO-mediated mechanism, and also with Nup358 and members of the Nup107-160 complex at distinct regions of SENP2 that can independently direct SENP2 to the nuclear rim. SENP1 and SENP2 are not required for localization of the transmembrane proteins nucleoporin POM121 and inner nuclear envelope protein Sun1 or expansion of the interphase nuclear envelope
physiological function
-
SENP2, but not SENP1, regulates MEF2A deSUMOylation in an activity dependent manner, enzyme SENP2 markedly enhances the transcription of MEF2A through directly deSUMOylation
physiological function
-
SUMO-specific protease 2 suppresses cell migration and invasion through selectively inhibiting the expression of MMP13 in bladder cancer cells, the enzyme has an indispensable role in the regulation of NF-kappaB transcriptional activation and Wnt signaling. The enzyme inhibits bladder cancer cells migration and invasion in vitro
physiological function
-
the broad deSUMOylation activity of the enzyme in vitro is essential for embryonic heart development, essential role of small ubiquitin-like modifier-specific protease 2 in myostatin expression and myogenesis, overview. Enzyme SENP2 regulates the transcription of myostatin mainly through deSUMOylation of MEF2A. MEF2A mediates SENP2 activity on the myostatin promoter involving the MEF2 binding site. Enzyme SENP2 inhibits skeletal myogenesis
physiological function
-
the SUMO proteases play roles both in processing SUMO during the biogenesis of this peptide moiety and also in reversing SUMO modification on specific targets to control the activities conferred by this posttranslational modification. Specificity of the role for SENP1 and SENP2 in maintaining desumoylation of Nup153
physiological function
adipocyte Senp2 deficiency results in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feeding. SET domain bifurcated 1 (Setdb1) is a SUMOylated protein and SUMOylation promotes Setdb1 occupancy on the promoter locus of Pparg and Cebpa genes to suppress their expressions via histone H3K9me3. Senp2 can suppress Setdb1 function by deSUMOylation. In adipocyte Senp2-deficiency mice, accumulation of the SUMOylated Setdb1 suppresses the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes
physiological function
development of a mouse strain permitting conditional inactivation of SENP2. Mice homozygous for germline deletion of the conditional allele exhibit trophoblast defects and embryonic abnormalities resembling the global SENP2 knockout. SENP2 is dispensable in embryogenesis. Placental expression of SENP2 is necessary and sufficient for embryonic heart and brain development. SENP2-dependent SUMO modification is required in development of all major trophoblast lineages. SENP2 regulates sumoylation of Mdm2 which controls p53 activities critical for G-S transition of mitotic division and endoreduplication in trophoblast proliferation and differentiation, respectively
physiological function
-
ectopic expression of SENP2 results in the suppression of proliferation, migration and invasion in osteosarcoma cells, whereas SENP2 knockdown has the opposite effect
physiological function
leptin treatment of C2C12 myotubes causes signal transducer and activator of transcription STAT3 to bind to the Senp2 promoter, inducing its expression. When Senp2 is knocked down in myotubes, leptin-induced expression of fatty acid oxidation-associated enzymes and prolonged increase of fatty acid oxidation are suppressed, but rapid increase of fatty acid oxidation is unaffected. Leptin-induced expression of fatty acid oxidation-associated enzymes is not observed in muscle tissue of SENP2 knockout mice
physiological function
SENP2 inhibits nuclear translocation of beta-catenin, which targets the promotor of MMP13 to activate MMP13 to enhance bladder cancer cell metastasis
physiological function
SENP2 interacts with Smad4 through SENP2 residue 363-400. The same segment is also important for desumoylation of Smad4, and able to relieve sumoylation-mediated TGF-beta repression. The SENP2363-400 segment is critical for TGF-beta-induced cell migration, which is correlated with SENP2363-400 deletion mutant that fails to increase matrix metalloproteinase (MMP)-9 and epithelial-to-mesenchymal transition marker gene expression. The interaction and desumoylation between SENP2 and Smad4 promote cell migration in triple-negative breast cancer cells
physiological function
SENP2 knockdown results in a decrease of E-cadherin and an increase of N-cadherin and fibronectin at both transcript and protein levels. SENP2 overexpression results in deSUMOylation of TGF-betaR I in bladder cancer cells and suppresses TGF-beta signaling and TGF-beta-induced epithelial-mesenchymal transition. SENP2 regulates TGF-beta signaling partly through deSUMOylation of TGFbeta receptor I
physiological function
-
the broad deSUMOylation activity of the enzyme in vitro is essential for embryonic heart development, essential role of small ubiquitin-like modifier-specific protease 2 in myostatin expression and myogenesis, overview. Enzyme SENP2 regulates the transcription of myostatin mainly through deSUMOylation of MEF2A. MEF2A mediates SENP2 activity on the myostatin promoter involving the MEF2 binding site. Enzyme SENP2 inhibits skeletal myogenesis
-
additional information
-
Correlation of Senp2 and myostatin expression in cachexia
additional information
-
SENP2 is a target of SUMO modification and has targeting preference for SUMO paralogues and substrates
additional information
-
Correlation of Senp2 and myostatin expression in cachexia
-
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C548S
site-directed mutagenesis, active site mutant
C549A
-
catalytically inactive mutant
F393G/K394G
construction of a chimeric enzyme SENP2 mutant with the insertion of loop1 from SENP6 into its sequence causing mutation of F393G/K394G, loop1 insertion is a determinant for SUMO2/3 activity and specificity, structure of SENP2-loop1 in complex with SUMO2, overview. The mutant reveals the details of an interface exclusive to SENP6/7 and the formation of unique contacts between both proteins, and the mutant shows an increase of the proteolytic activity for diSUMO2 and polySUMO2 substrates. The chimeric insertion mutant used for crystallization studies is also mutated at active site residue, C548S, for a stable complex formation
G545D
slight decrease in SUMO-1 processing activity and SUMO-2 processing activity. Decrease in cleavage of the RanGAP1-SUMO-1 conjugate
G545F
decrease in SUMO-1 processing activitya and SUMO-2 processing activity. Increase in SUMO-3 procesing activity
G545S
decrease in SUMO-1 processing activity, SUMO-2 processing activity and SUMO-3 procesing activity. Decrease in cleavage of the RanGAP1-SUMO-1 conjugate
M497A
increase in SUMO-1 processing activity and SUMO-3 procesing activity. Decrease in cleavage of the RanGAP1-SUMO-1 conjugate. Slight decrease in cleavage of the RanGAP1-SUMO-2/3 conjugate
M497L
decrease in SUMO-1 processing activity, SUMO-2 processing activity and SUMO-3 procesing activity
M497N
slight increase in SUMO-1 processing activity, decrease in SUMO-2 processing activity. Decrease in cleavage of the RanGAP1-SUMO-1 conjugate
M497Q
decrease in SUMO-1 processing activity, SUMO-2 processing activity and SUMO-3 procesing activity. Decrease in cleavage of the RanGAP1-SUMO-1 conjugate. Decrease in cleavage of the RanGAP1-SUMO-2/3 conjugate
V477A
substitution results in mild effects on processing or deconjugation
C548S
catalytically inactive mutant
R576L/K577M
-
the catalytically inactive enzyme mutant SENP2Cat cannot regulate MMP13
R576L/K577M
catalytically inactive SENP2 mutant, unable to regulate TGF-beta signaling
additional information
-
enzyme knockout by RNA interference in MCF-7 cells
additional information
-
enzyme knockout by siRNA against SENP2
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Itahana, Y.; Yeh, E.T.; Zhang, Y.
Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
Mol. Cell. Biol.
26
4675-4689
2006
Homo sapiens (Q9HC62)
brenda
Reverter, D.; Lima, C.D.
Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates
Nat. Struct. Mol. Biol.
13
1060-1068
2006
Homo sapiens (Q9HC62)
brenda
Jiang, M.; Chiu, S.Y.; Hsu, W.
SUMO-specific protease 2 in Mdm2-mediated regulation of p53
Cell Death Differ.
18
1005-1015
2011
Mus musculus
brenda
Ban, R.; Nishida, T.; Urano, T.
Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
Genes Cells
16
652-669
2011
Homo sapiens
brenda
Hang, J.; Dasso, M.
Association of the human SUMO-1 protease SENP2 with the nuclear pore
J. Biol. Chem.
277
19961-19966
2002
Homo sapiens (Q9HC62)
brenda
Mikolajczyk, J.; Drag, M.; Bekes, M.; Cao, J.T.; Ronai, Z.; Salvesen, G.S.
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
J. Biol. Chem.
282
26217-26224
2007
Homo sapiens
brenda
Chung, S.S.; Ahn, B.Y.; Kim, M.; Choi, H.H.; Park, H.S.; Kang, S.; Park, S.G.; Kim, Y.B.; Cho, Y.M.; Lee, H.K.; Chung, C.H.; Park, K.S.
Control of adipogenesis by the SUMO-specific protease SENP2
Mol. Cell. Biol.
30
2135-2146
2010
Mus musculus (Q91ZX6)
brenda
Kang, X.; Qi, Y.; Zuo, Y.; Wang, Q.; Zou, Y.; Schwartz, R.J.; Cheng, J.; Yeh, E.T.
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development
Mol. Cell
38
191-201
2010
Mus musculus (Q91ZX6)
brenda
Chiu, S.Y.; Asai, N.; Costantini, F.; Hsu, W.
SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
PLoS Biol.
6
e310
2008
Mus musculus
brenda
Reverter, D.; Lima, C.D.
A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
Structure
12
1519-1531
2004
Homo sapiens (Q9HC62)
brenda
Tan, M.Y.; Mu, X.Y.; Liu, B.; Wang, Y.; Bao, E.D.; Qiu, J.X.; Fan, Y.
SUMO-specific protease 2 suppresses cell migration and invasion through inhibiting the expression of MMP13 in bladder cancer cells
Cell. Physiol. Biochem.
32
542-548
2013
Homo sapiens
brenda
Koo, Y.D.; Choi, J.W.; Kim, M.; Chae, S.; Ahn, B.Y.; Kim, M.; Oh, B.C.; Hwang, D.; Seol, J.H.; Kim, Y.B.; Park, Y.J.; Chung, S.S.; Park, K.S.
SUMO-specific protease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle
Diabetes
64
2420-2431
2015
Mus musculus
brenda
Qi, Y.; Zuo, Y.; Yeh, E.T.; Cheng, J.
An essential role of small ubiquitin-like modifier (SUMO)-specific protease 2 in myostatin expression and myogenesis
J. Biol. Chem.
289
3288-3293
2014
Mus musculus, Mus musculus C57BL/6
brenda
Cubenas-Potts, C.; Goeres, J.D.; Matunis, M.J.
SENP1 and SENP2 affect spatial and temporal control of sumoylation in mitosis
Mol. Biol. Cell
24
3483-3495
2013
Homo sapiens (Q9HC62)
brenda
Chow, K.H.; Elgort, S.; Dasso, M.; Powers, M.A.; Ullman, K.S.
The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
Mol. Biol. Cell
25
160-168
2014
Homo sapiens
brenda
Lu, H.; Liu, B.; You, S.; Chen, L.; Dongmei, Q.; Gu, M.; Lu, Y.; Chen, Y.; Zhang, F.; Yu, B.
SENP2 regulates MEF2A de-SUMOylation in an activity dependent manner
Mol. Biol. Rep.
40
2485-2490
2013
Homo sapiens
brenda
Chow, K.H.; Elgort, S.; Dasso, M.; Ullman, K.S.
Two distinct sites in Nup153 mediate interaction with the SUMO proteases SENP1 and SENP2
Nucleus
3
349-358
2012
Homo sapiens
brenda
Tang, S.; Huang, G.; Tong, X.; Xu, L.; Cai, R.; Li, J.; Zhou, X.; Song, S.; Huang, C.; Cheng, J.
Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism
PLoS ONE
8
e63965
2013
Homo sapiens, Mus musculus
brenda
Alegre, K.O.; Reverter, D.
Structural insights into the SENP6 loop1 structure in complex with SUMO2
Protein Sci.
23
433-441
2014
Homo sapiens (Q9HC62)
brenda
Pei, H.; Chen, L.; Liao, Q.M.; Wang, K.J.; Chen, S.G.; Liu, Z.J.; Zhang, Z.C.
SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation
Exp. Ther. Med.
16
5359-5365
2018
Homo sapiens
brenda
Zheng, Q.; Cao, Y.; Chen, Y.; Wang, J.; Fan, Q.; Huang, X.; Wang, Y.; Wang, T.; Wang, X.; Ma, J.; Cheng, J.
Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1
J. Mol. Cell Biol.
10
258-266
2018
Mus musculus (Q91ZX6)
brenda
Koo, Y.D.; Lee, J.S.; Lee, S.A.; Quaresma, P.G.F.; Bhat, R.; Haynes, W.G.; Park, Y.J.; Kim, Y.B.; Chung, S.S.; Park, K.S.
SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle
Metab. Clin. Exp.
95
27-35
2019
Mus musculus (Q91ZX6)
brenda
Tan, M.; Zhang, D.; Zhang, E.; Xu, D.; Liu, Z.; Qiu, J.; Fan, Y.; Shen, B.
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-betaRI
Mol. Carcinog.
56
2332-2341
2017
Homo sapiens (Q9HC62)
brenda
Tan, M.; Gong, H.; Wang, J.; Tao, L.; Xu, D.; Bao, E.; Liu, Z.; Qiu, J.
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1
Sci. Rep.
5
13996
2015
Homo sapiens (Q9HC62)
brenda
Maruyama, E.O.; Lin, H.; Chiu, S.Y.; Yu, H.M.; Porter, G.A.; Hsu, W.
Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development
Sci. Rep.
6
20999
2016
Mus musculus (Q91ZX6)
brenda
Chang, C.C.; Huang, Y.S.; Lin, Y.M.; Lin, C.J.; Jeng, J.C.; Liu, S.M.; Ho, T.L.; Chang, R.T.; Changou, C.A.; Ho, C.C.; Shih, H.M.
The role of sentrin-specific protease 2 substrate recognition in TGF-beta-induced tumorigenesis
Sci. Rep.
8
9786
2018
Homo sapiens (Q9HC62)
brenda