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Disease on EC 3.4.22.68 - Ulp1 peptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Altitude Sickness
Genetic variation in SENP1 and ANP32D as predictors of chronic mountain sickness.
SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders.
Anemia
SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
Arthritis, Rheumatoid
Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression.
Astrocytoma
Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-?B/Akt pathways.
Ataxia Telangiectasia
NF-?B Induction of the SUMO Protease SENP2: A Negative Feedback Loop to Attenuate Cell Survival Response to Genotoxic Stress.
Atherosclerosis
Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.
Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior.
SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.
Autoimmune Diseases
Epigenetics and rheumatoid arthritis: The role of SENP1 in the regulation of MMP-1 expression.
Brain Ischemia
Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Breast Neoplasms
A SUMOylation-dependent HIF-1?/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis.
Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
Regulation of post-translational modification in breast cancer treatment.
SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function.
SENP2 suppresses NF-?B activation and sensitizes breast cancer cells to doxorubicin.
SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression.
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.
Transcriptional repression of estrogen receptor ? signaling by SENP2 in breast cancer cells.
Burkitt Lymphoma
Down-regulation of SENP1 Expression Increases Apoptosis of Burkitt Lymphoma Cells.
Carcinogenesis
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
SENP1 regulates PTEN stability to dictate prostate cancer development.
SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.
The Epstein-Barr Virus Oncoprotein, LMP1, Regulates the Function of SENP2, a SUMO-protease.
The in vivo functions of desumoylating enzymes.
The SUMO-specific protease SENP5 controls DNA damage response and promotes tumorigenesis in hepatocellular carcinoma.
Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
[A verification study on the genes associated with laryngeal squamous cell carcinoma by cDNA microarray]
[SUMO-specific protease 1 and cancer]
Carcinoma
Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes.
Inhibition of SENP1 induces radiosensitization in lung cancer cells.
SENP1 Interacts with HIF1? to Regulate Glycolysis of Prostatic Carcinoma Cells.
SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.
SENP1 regulates PTEN stability to dictate prostate cancer development.
The SUMO protease SENP1 is required for cohesion maintenance and mitotic arrest following spindle poison treatment.
Carcinoma, Hepatocellular
Inhibition of SENP6-Induced Radiosensitization of Human Hepatocellular Carcinoma Cells by Blocking Radiation-Induced NF-?B Activation.
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma.
SENP2 regulated the stability of ?-catenin through WWOX in hepatocellular carcinoma cell.
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of ?-catenin.
The SUMO-specific protease SENP5 controls DNA damage response and promotes tumorigenesis in hepatocellular carcinoma.
Carcinoma, Ovarian Epithelial
Upregulation of SENP3/SMT3IP1 promotes epithelial ovarian cancer progression and forecasts poor prognosis.
Carcinoma, Renal Cell
SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.
Carcinoma, Squamous Cell
Coamplification and Cooperation: Toward Identifying Biologically Relevant Oncogenes.
Cardiomegaly
Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy.
Cardiomyopathies
Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy.
Cardiovascular Diseases
Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition.
SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1.
Cataract
Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses.
Colonic Neoplasms
Identification of SENP1 inhibitors through in silico screening and rational drug design.
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
SENP1 participates in Irinotecan resistance in human colon cancer cells.
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors.
Colorectal Neoplasms
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.
SENP1 participates in Irinotecan resistance in human colon cancer cells.
Congenital Abnormalities
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Coronary Disease
SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1?-dependent pathway.
Diabetes Mellitus
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
The role of adipose-derived inflammatory cytokines in type 1 diabetes.
Diabetes Mellitus, Type 2
How do reducing equivalents increase insulin secretion?
Senp2 expression was induced by chronic glucose stimulation in INS1 cells, and it was required for the associated induction of Ccnd1 and Mafa.
Diabetic Retinopathy
SENP1-Mediated Desumoylation of DBC1 Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes.
Drug-Related Side Effects and Adverse Reactions
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Epilepsy
Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior.
Epstein-Barr Virus Infections
The Epstein-Barr Virus Oncoprotein, LMP1, Regulates the Function of SENP2, a SUMO-protease.
Fatty Liver
Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Glioblastoma
Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells.
SUMOylation Regulator-Related Molecules Can Be Used as Prognostic Biomarkers for Glioblastoma.
Glioma
Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells.
Glucose Intolerance
?-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High Fat Diet-Fed Mice.
How do reducing equivalents increase insulin secretion?
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ? cells.
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Head and Neck Neoplasms
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Heart Defects, Congenital
Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development.
Heart Septal Defects, Ventricular
Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Herpes Simplex
Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Hyperalgesia
TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain.
Hypertension, Pulmonary
Hypoxia Triggers SENP1 (Sentrin-Specific Protease 1) Modulation of KLF15 (Kruppel-Like Factor 15) and Transcriptional Regulation of Arg2 (Arginase 2) in Pulmonary Endothelium.
[The expression and possible role of SENP1 in the pulmonary vascular wall of rat during the development of hypoxic pulmonary hypertension].
Infarction, Middle Cerebral Artery
SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion.
Infections
Cardiomyocyte-specific deletion of Senp2 contributes to CVB3 viral replication and inflammation.
Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.
SUMO Suppresses the Activity of the Jasmonic Acid Receptor CORONATINE INSENSITIVE1.
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.
The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/Sentrin-Specific Peptidase 6 To Facilitate Establishment of Latency.
[Ribosomal Protein S9 Expression in Multiple Myeloma and Its Effect on Cell Biological Function].
Insulin Resistance
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1.
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Ischemic Stroke
Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
Laryngeal Neoplasms
Detection of differentially expressed genes and association with clinicopathological features in laryngeal squamous cell carcinoma.
Leukemia
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.
Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts.
SUMO-specific protease 2 in Mdm2-mediated regulation of p53.
Leukemia, Lymphocytic, Chronic, B-Cell
SENP2 exerts an anti?tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF??B signaling pathways.
Leukemia, Promyelocytic, Acute
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.
Liver Cirrhosis
SENP1 attenuates the liver fibrosis through down-regulating the expression of SMAD2.
Lung Injury
Role of the SENP1-SIRT1 pathway in hyperoxia-induced alveolar epithelial cell injury.
Lung Neoplasms
Inhibition of SENP1 induces radiosensitization in lung cancer cells.
Up-regulation of microRNA-138 induce radiosensitization in lung cancer cells.
Lymphatic Metastasis
Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Lymphoma
SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein.
Melanoma
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Multiple Myeloma
SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-?B signaling.
Silencing of SENP2 in Multiple Myeloma Induces Bortezomib Resistance by Activating NF-?B Through the Modulation of I?B? Sumoylation.
Myocarditis
Cardiomyocyte-specific deletion of Senp2 contributes to CVB3 viral replication and inflammation.
Neoplasm Metastasis
A SUMOylation-dependent HIF-1?/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis.
Association of SENPs single-nucleotide polymorphism and breast cancer in Chinese population.
Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells.
Discovery of a Class of Potent and Selective Non-competitive Sentrin-Specific Protease 1 Inhibitors.
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3.
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma.
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-?RI.
Small ubiquitin-like modifier/sentrin-specific peptidase 1 associates with chemotherapy and is a risk factor for poor prognosis of non-small cell lung cancer.
Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
SUMO-specific protease 1 promotes prostate cancer progression and metastasis.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Neoplasms
A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer.
ARF-mediated SUMOylation of Apak antagonizes ubiquitylation and promotes its nucleolar accumulation to inhibit 47S pre-rRNA synthesis.
Comprehensive in silico analysis for identification of novel candidate target genes, including DHX36, OPA1, and SENP2, located on chromosome 3q in head and neck cancers.
Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression.
Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells.
Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.
Differential regulation of sentrinized proteins by a novel sentrin-specific protease.
Downregulation of SENP1 inhibits cell proliferation, migration and promotes apoptosis in human glioma cells.
Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-?B interaction.
E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort.
Exploring the Desumoylation Process of SENP1: A Study Combined MD Simulations with QM/MM Calculations on SENP1-SUMO1-RanGAP1.
Genetic Polymorphism of SUMO-Specific Cysteine Proteases - SENP1 and SENP2 in Breast Cancer.
Ginger DNA transposons in eukaryotes and their evolutionary relationships with long terminal repeat retrotransposons.
Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors.
Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition.
Identification of SENP1 inhibitors through in silico screening and rational drug design.
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
microRNA-186 Suppresses Cell Proliferation and Metastasis Through Targeting Sentrin Specific Protease 1 in Renal Cell Carcinoma.
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.
Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells.
Plasma Exosome-Derived SENP1 May Be a Potential Prognostic Predictor for Melanoma.
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma.
Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy.
Role of desumoylation in the development of prostate cancer.
Salivary proteomics of canine oral tumors using MALDI-TOF mass spectrometry and LC-tandem mass spectrometry.
SENP1 activity sustains cancer stem cell in hypoxic HCC.
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
SENP1 Interacts with HIF1? to Regulate Glycolysis of Prostatic Carcinoma Cells.
SENP1 is a crucial promotor for hepatocellular carcinoma through deSUMOylation of UBE2T.
SENP1 promotes hypoxia-induced cancer stemness by HIF-1? deSUMOylation and SENP1/HIF-1? positive feedback loop.
SENP1 promotes MCL pathogenesis through regulating JAK-STAT5 pathway and SOCS2 expression.
SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis.
SENP2 exerts an anti?tumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NF??B signaling pathways.
SENP2 regulated the stability of ?-catenin through WWOX in hepatocellular carcinoma cell.
SENP2 regulates hepatocellular carcinoma cell growth by modulating the stability of ?-catenin.
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-?RI.
SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
Small ubiquitin-like modifier/sentrin-specific peptidase 1 associates with chemotherapy and is a risk factor for poor prognosis of non-small cell lung cancer.
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase.
SUMO protease SENP1 deSUMOylates and stabilizes c-Myc.
SUMO Protease SMT7 Modulates Ribosomal Protein L30 and Regulates Cell-size Checkpoint Function.
SUMO-specific protease 1 promotes prostate cancer progression and metastasis.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation.
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells.
Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death.
The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion.
The role of sentrin-specific protease 2 substrate recognition in TGF-?-induced tumorigenesis.
The SUMO-specific protease family regulates cancer cell radiosensitivity.
The SUMO-specific protease SENP1 deSUMOylates p53 and regulates its activity.
Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.
Neuroblastoma
SENP1 regulates cell migration and invasion in neuroblastoma.
Neurodegenerative Diseases
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.
Neuroinflammatory Diseases
Depletion of SENP1-mediated PPAR? SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation.
Ethanol Exposure Induces Microglia Activation and Neuroinflammation through TLR4 Activation and SENP6 Modulation in the Adolescent Rat Hippocampus.
SENP1 modulates microglia-mediated neuroinflammation toward intermittent hypoxia-induced cognitive decline through the de-SUMOylation of NEMO.
Obesity
Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1.
SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle.
Osteosarcoma
Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Plasma Exosome-Derived Sentrin SUMO-Specific Protease 1: A Prognostic Biomarker in Patients With Osteosarcoma.
SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation.
[Corrigendum] Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV.
Ovarian Neoplasms
SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1?.
SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance.
Pancreatic Neoplasms
A cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer.
SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9.
Paralysis
Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Placental Insufficiency
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Polycythemia
Interaction of CARD14, SENP1 and VEGFA polymorphisms on susceptibility to high altitude polycythemia in the Han Chinese population at the Qinghai-Tibetan Plateau.
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.
Primary Ovarian Insufficiency
Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression.
Prostatic Intraepithelial Neoplasia
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
Role of desumoylation in the development of prostate cancer.
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
Prostatic Neoplasms
Assays for Investigating deSUMOylation Enzymes.
CDX2/mir-145-5p/SENP1 Pathways Affect LNCaP Cells Invasion and Migration.
Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.
Discovery of a Class of Potent and Selective Non-competitive Sentrin-Specific Protease 1 Inhibitors.
Identification of SENP1 inhibitors through in silico screening and rational drug design.
Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells.
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer.
Momordin Ic, a new natural SENP1 inhibitor, inhibits prostate cancer cell proliferation.
Role of desumoylation in the development of prostate cancer.
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms.
SENP1 Interacts with HIF1? to Regulate Glycolysis of Prostatic Carcinoma Cells.
SENP1 regulates PTEN stability to dictate prostate cancer development.
SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression.
SUMO-Specific Cysteine Protease 1 Promotes Epithelial Mesenchymal Transition of Prostate Cancer Cells via Regulating SMAD4 deSUMOylation.
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.
SUMO-specific protease 1 promotes prostate cancer progression and metastasis.
Sumoylation Negatively Regulates CSR1-Dependent Prostate Cancer Cell Death.
The prognostic value of SUMO1/Sentrin specific peptidase 1 (SENP1) in prostate cancer is limited to ERG-fusion positive tumors lacking PTEN deletion.
Tumor-suppressive microRNA-145 induces growth arrest by targeting SENP1 in human prostate cancer cells.
Reperfusion Injury
Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury by regulating Annexin-A1 nuclear translocation-associated neuronal apoptosis.
Respiratory Distress Syndrome, Newborn
Budesonide and Poractant Alfa prevent bronchopulmonary dysplasia via triggering SIRT1 signaling pathway.
Retinoblastoma
SUMO Protease SMT7 Modulates Ribosomal Protein L30 and Regulates Cell-size Checkpoint Function.
Rubella
HEARTBREAK Controls Post-translational Modification of INDEHISCENT to Regulate Fruit Morphology in Capsella.
Seizures
Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.
The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
Sepsis
Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-?B interaction.
SUMO protease SENP1 acts as a ceRNA for TGFBR2 and thus activates TGFBR2/Smad signaling responsible for LPS-induced sepsis.
Sleep Apnea, Obstructive
SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro.
Starvation
SENP2-PLC?4 signaling regulates neurogenesis through the maintenance of calcium homeostasis.
Stomach Neoplasms
Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells.
SUMO-specific protease 6 promotes gastric cancer cell growth via deSUMOylation of FoxM1.
Stroke
Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Teratoma
Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).
Thrombosis
Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Triple Negative Breast Neoplasms
Depletion of SENP1 suppresses the proliferation and invasion of triple-negative breast cancer cells.
The role of sentrin-specific protease 2 substrate recognition in TGF-?-induced tumorigenesis.
ulp1 peptidase deficiency
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.
Hepatic Small Ubiquitin-Related Modifier (SUMO)-Specific Protease 2 Controls Systemic Metabolism Through SUMOylation-Dependent Regulation of Liver-Adipose Tissue Crosstalk.
Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death.
Inhibition of p53 deSUMOylation exacerbates puromycin aminonucleoside-induced apoptosis in podocytes.
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism.
SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation.
SENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1.
SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1?-dependent pathway.
SENP1-mediated deSUMOylation of JAK2 regulates its kinase activity and platinum drug resistance.
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Senp2 Regulates Adipose Lipid Storage by De-SUMOylation of Setdb1.
SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.
Stromal Senp1 promotes mouse early folliculogenesis by regulating BMP4 expression.
SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.
The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics.
Urinary Bladder Neoplasms
Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts.
SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1.
SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-?RI.
SUMO-Specific Protease 2 Suppresses Cell Migration and Invasion through Inhibiting the Expression of MMP13 in Bladder Cancer Cells.
Virus Diseases
Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5.
Vitiligo
Decreased SUMOylation of the retinoblastoma protein in keratinocytes during the pathogenesis of vitiligo.