Disease on EC 3.4.22.55 - caspase-2

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DISEASE
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Acrocephalosyndactylia
Twist haploinsufficiency in Saethre-Chotzen syndrome induces calvarial osteoblast apoptosis due to increased TNFalpha expression and caspase-2 activation.
Adenocarcinoma
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Adenocarcinoma of Lung
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
Adenoma, Pleomorphic
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Alzheimer Disease
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease.
Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.
Changes in caspase expression in Alzheimer's disease: comparison with development and aging.
THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.
Amyloidosis
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Astrocytoma
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.
Ataxia
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
Ataxia Telangiectasia
Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome.
Bacterial Infections
Old and Novel Functions of Caspase-2.
Brain Injuries
Combined effect of hypothermia and caspase-2 gene deficiency on neonatal hypoxic-ischemic brain injury.
Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.
Brain Ischemia
Two caspase-2 transcripts are expressed in rat hippocampus after global cerebral ischemia.
Brain Neoplasms
Gene expression profiling of metastatic brain cancer.
Breast Neoplasms
A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.
Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (mcf-7).
Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression.
Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells.
The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events.
The potential role of free chitosan in bone trauma and bone cancer management.
The role of individual caspases in cell death induction by taxanes in breast cancer cells.
Carcinogenesis
A tumor suppressor function for caspase-2.
An unexpected role for caspase-2 in neuroblastoma.
Caspase-2 as a tumour suppressor.
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
Old, new and emerging functions of caspases.
Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.
Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Carcinoma
Attenuation of the ELAV1-like protein HuR sensitizes adenocarcinoma cells to the intrinsic apoptotic pathway by increasing the translation of caspase-2L.
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Caspase-2 is a negative regulator of necroptosis.
Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21(WAF1/CIP1).
DNA damage induces two distinct modes of cell death in ovarian carcinomas.
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.
Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells.
Loss of caspase-2, -6 and -7 expression in gastric cancers.
miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2.
PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells.
Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.
Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.
The association of taxane resistance genes with the clinical course of ovarian carcinoma.
Topoisomerase I and II inhibitors control caspase-2 pre-messenger RNA splicing in human cells.
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.
Carcinoma, Hepatocellular
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Carcinoma, Mucoepidermoid
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Carcinoma, Ovarian Epithelial
Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene.
Carcinoma, Renal Cell
PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
Cardiotoxicity
Lovastatin-induced cardiac toxicity involves both oncotic and apoptotic cell death with the apoptotic component blunted by both caspase-2 and caspase-3 inhibitors.
caspase-2 deficiency
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Caspase-2 deficiency enhances aging-related traits in mice.
Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.
Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function.
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
Caspase-2 deficiency protects mice from diabetes-induced marrow adiposity.
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Caspase-2 protects against oxidative stress in vivo.
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.
Cholangiocarcinoma
Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.
Colonic Neoplasms
Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.
Caspase-4 is essential for saikosaponin a-induced apoptosis acting upstream of caspase-2 and ?-H2AX in colon cancer cells.
Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis.
MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
Simulated colon fiber metabolome regulates genes involved in cell cycle, apoptosis, and energy metabolism in human colon cancer cells.
Colorectal Neoplasms
BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer.
Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.
Silencing of the mRNA-binding protein HuR increases the sensitivity of colorectal cancer cells to ionizing radiation through upregulation of caspase-2.
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
T25 repeat in the 3' untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer.
Dementia
THD-Module Extractor: An Application for CEN Module Extraction and Interesting Gene Identification for Alzheimer's Disease.
Dysgeusia
Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells.
Epilepsy
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Epilepsy, Temporal Lobe
Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.
Fatty Liver
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Fibrosarcoma
PIDDosome-independent tumor suppression by Caspase-2.
Glaucoma
Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats.
Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.
Glioblastoma
Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain.
Glioma
microRNA-149 targets caspase-2 in glioma progression.
Glucose Intolerance
Old and Novel Functions of Caspase-2.
Heart Failure
Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.
Hematologic Neoplasms
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.
Hepatitis
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Hepatitis C
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Huntington Disease
Increased caspase-2, calpain activations and decreased mitochondrial complex II activity in cells expressing exogenous huntingtin exon 1 containing CAG repeat in the pathogenic range.
Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington Disease.
Infection
Apoptosis in cultured cells infected with feline calicivirus.
Caspase-2 mediated apoptotic and necrotic murine macrophage cell death induced by rough Brucella abortus.
Caspase-mediated cleavage of the feline calicivirus capsid protein.
Cloning and expression of the cDNA encoding rat caspase-2.
HIV induces lymphocyte apoptosis by a p53-initiated, mitochondrial-mediated mechanism.
Inhibition of apoptosis in Cryptosporidium parvum-infected intestinal epithelial cells is dependent on survivin.
Intrinsic apoptosis and proinflammatory cytokines regulated in human astrocytes infected with enterovirus 71.
Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation.
Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.
Old and Novel Functions of Caspase-2.
Reactivation of Nedd-2, a developmentally down-regulated apoptotic gene, in apoptosis induced by a street strain of rabies virus.
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]
Insulin Resistance
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.
Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice.
Leukemia
Apoptosis-inducing active components from Corbicula fluminea through activation of caspase-2 and production of reactive oxygen species in human leukemia HL-60 cells.
Association of caspase-2 with the promyelocytic leukemia protein nuclear bodies.
BMP4 is Involved in the Chemoresistance of Myeloid Leukemia Cells Through Regulating Autophagy-Apoptosis Balance.
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Modification of survival pathway gene expression in human breast cancer cells by tetraiodothyroacetic acid (tetrac).
Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.
Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt.
Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers.
Leukemia, Lymphoid
Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells.
Leukemia, Myeloid, Acute
Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.
Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia.
The clinical significance of caspase regulation in acute leukemia.
Lichen Planus, Oral
Metallothionein, a marker of antiapoptosis, is associated with clinical forms of oral lichen planus.
Liver Cirrhosis
Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis.
Liver Diseases
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.
Old and Novel Functions of Caspase-2.
Liver Diseases, Alcoholic
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.
Liver Neoplasms
Caspase-2 deficiency accelerates chemically induced liver cancer in mice.
Lung Neoplasms
A synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), triggers reactive oxygen species-induced apoptosis independently of p53 in A549 lung cancer cells.
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Lymphoma
A tumor suppressor function for caspase-2.
An unexpected role for caspase-2 in neuroblastoma.
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.
PIDDosome-independent tumor suppression by Caspase-2.
The engine driving the ship: metabolic steering of cell proliferation and death.
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Lymphoma, B-Cell
Induced cell death pathway post photodynamic therapy using a metallophthalocyanine photosensitizer in breast cancer cells.
The engine driving the ship: metabolic steering of cell proliferation and death.
Lymphoma, B-Cell, Marginal Zone
CpG oligodeoxynucleotide 5mer-induced apoptosis in MOLT-4 leukaemia cells does not require caspase 3 or new protein synthesis.
Lymphopenia
Mapping of caspase-2 in the rat and its exclusion as a candidate gene for lymphopenia.
Melanoma
Camptothecin induces p53-dependent and -independent apoptogenic signaling in melanoma cells.
Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.
H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells.
Increased Caspase-2 Activity is Associated With Induction of Apoptosis in IFN-beta Sensitive Melanoma Cell Lines.
NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma.
Memory Disorders
Caspase-2 cleavage of tau reversibly impairs memory.
Metabolic Syndrome
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Mouth Neoplasms
Soy protein extract (SPE) exhibits differential in vitro cell proliferation effects in oral cancer and normal cell lines.
Multiple Myeloma
Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells.
Neoplasm Metastasis
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.
Neoplasms
5-Phenylselenyl- and 5-methylselenyl-methyl-2'-deoxyuridine induce oxidative stress, DNA damage, and caspase-2-dependent apoptosis in cancer cells.
A caspase-2-RFXANK interaction and its implication for MHC class II expression.
A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.
A tumor suppressor function for caspase-2.
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis.
An unexpected role for caspase-2 in neuroblastoma.
Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.
Apoptosis is signalled early by low doses of ionising radiation in a radiation-induced bystander effect.
Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.
Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat.
BCL9L Dysfunction Promotes Aneuploidy Tolerance in Colon Tumors.
Beta-carotene: a colorful killer of cancer cells? A commentary on "ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis".
Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.
Cardiac glycoside-induced cell death and Rho/Rho kinase pathway: Implication of different regulation in cancer cell lines.
Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?
Caspase 2-mediated tumor suppression involves survivin gene silencing.
Caspase-2 activation is redundant during seizure-induced neuronal death.
Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.
Caspase-2 as a tumour suppressor.
Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.
Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo.
Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.
Caspase-2 protects against oxidative stress in vivo.
Caspase-2 protocols.
Caspase-2 regulates oncogene-induced senescence.
Caspase-2-mediated cell death is required for deleting aneuploid cells.
Caspase-2/NEDD-2 protease mediates execution of apoptosis in AK-5 tumor cells.
Caspase-2: a possible trigger of apoptosis induced in A-549 tumor cells by ZnPc photodynamic treatment.
Caspase-2: controversial killer or checkpoint controller?
Caspase-2: the orphan caspase.
Caspase-2: the reinvented enzyme.
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains.
Crocetin exploits p53-induced death domain (PIDD) and FAS-associated death domain (FADD) proteins to induce apoptosis in colorectal cancer.
Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators.
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Effect of homeopathic treatment on gene expression in Copenhagen rat tumor tissues.
Essential roles of the Bcl-2 family of proteins in caspase-2-induced apoptosis.
Establishment of human prostate tumor xenografts in nude mice and response to 9-nitrocamptothecin in vivo and in vitro does not correlate with the expression of various apoptosis-regulating proteins.
Estrogen receptor beta decreases survival of p53-defective cancer cells after DNA damage by impairing G(2)/M checkpoint signaling.
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice.
Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters.
High levels of expression and nuclear localization of interleukin-1 beta converting enzyme (ICE) and CPP32 in favorable human neuroblastomas.
Histone deacetylase inhibitors enhance Ad5-TRAIL killing of TRAIL-resistant prostate tumor cells through increased caspase-2 activity.
Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology.
Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice.
Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.
Importance of transcript levels of caspase-2 isoforms S and L for breast carcinoma progression.
In situ analysis of Raidd-beta-galactosidase fusion gene expression in transgenic mouse midgestation embryos.
Indication of participation of caspase-2 and caspase-5 in mechanisms of human cervical malignancy.
Induction of caspase-2 activation by a DNA enzyme evokes tumor cell apoptosis.
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Inhibition of microRNA-383 has tumor suppressive effect in human epithelial ovarian cancer through the action on caspase-2 gene.
Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer.
Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.
Melittin induces NSCLC apoptosis via inhibition of miR-183.
microRNA-149 targets caspase-2 in glioma progression.
MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
Molecular differentiation of early and late stage laryngeal squamous cell carcinoma: an exploratory analysis.
Natural agents targeting the alpha7-nicotinic-receptor in NSCLC: a promising prospective in anti-cancer drug development.
Next-Generation Sequencing Analysis Reveals Differential Expression Profiles of MiRNA-mRNA Target Pairs in KSHV-Infected Cells.
Old and Novel Functions of Caspase-2.
Old, new and emerging functions of caspases.
Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells.
PIDDosome expression and the role of caspase-2 activation for chemotherapy-induced apoptosis in RCCs.
PIDDosome-independent tumor suppression by Caspase-2.
Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion.
Renal sympathetic denervation improves myocardial apoptosis in rats with isoproterenol-induced heart failure by downregulation of tumor necrosis factor-? and nuclear factor-?B.
Secretory leukoprotease inhibitor inhibits cell growth through apoptotic pathway on ovarian cancer.
Somatic mutation of proapoptotic caspase-2 gene is rare in acute leukemias and common solid cancers.
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
Splicing factors of SR and hnRNP families as regulators of apoptosis in cancer.
Structural and enzymatic insights into caspase-2 substrate recognition and catalysis.
Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD.
Support for an infection-induced apoptotic pathway in human fetal membranes.
Tamoxifen enhances therapeutic effects of gemcitabine on cholangiocarcinoma tumorigenesis.
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.
The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development.
The role of caspase-2 in stress-induced apoptosis.
The Roles of ROS and Caspases in TRAIL-Induced Apoptosis and Necroptosis in Human Pancreatic Cancer Cells.
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
TRIM16 overexpression induces apoptosis through activation of caspase-2 in cancer cells.
Tumor necrosis factor-alpha-induced apoptosis in olfactory epithelium in vitro: possible roles of caspase 1 (ICE), caspase 2 (ICH-1), and caspase 3 (CPP32).
Tumor-suppressing function of caspase-2 requires catalytic site C320 and site S139 in mice.
Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.
[Caspase-2 as an Oncosupressor and Metabolism Regulator: What Life Will Bring over the Long Run?]
[Caspase-2: what do we know today?].
Neoplasms, Germ Cell and Embryonal
Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
Neuroblastoma
An unexpected role for caspase-2 in neuroblastoma.
Ca(2+)-independent caspase-3 but not Ca(2+)-dependent caspase-2 activation induced by oxidative stress leads to SH-SY5Y human neuroblastoma cell apoptosis.
Caspases-2, -3, and -7 are involved in thapsigargin-induced apoptosis of SH-SY5Y neuroblastoma cells.
Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.
Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe.
Old and Novel Functions of Caspase-2.
Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.
Transcriptome profiling of caspase-2 deficient E?Myc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling.
Neurodegenerative Diseases
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Non-alcoholic Fatty Liver Disease
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Vitamin B5 and N-Acetylcysteine in Nonalcoholic Steatohepatitis: A Preclinical Study in a Dietary Mouse Model.
Obesity
Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.
Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.
Optic Nerve Diseases
Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.
Optic Nerve Injuries
Ocular neuroprotection by siRNA targeting caspase-2.
Old and Novel Functions of Caspase-2.
Optic Neuritis
Pharmacological inhibition of caspase-2 protects axotomised retinal ganglion cells from apoptosis in adult rats.
Optic Neuropathy, Ischemic
Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection.
Osteosarcoma
c-Jun Is critical for the progression of osteosarcoma: proof in an orthotopic spontaneously metastasizing model.
c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis.
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Ovarian Neoplasms
Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Mechanism of caspase-2 activation upon DNA damage.
Pancreatic Neoplasms
The Race of 10 Synthetic RNAi-Based Drugs to the Pharmaceutical Market.
Pancreatitis
Inflammatory cells regulate p53 and caspases in acute pancreatitis.
Papilloma
Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Polycystic Kidney, Autosomal Dominant
Pathways of caspase-mediated apoptosis in autosomal-dominant polycystic kidney disease (ADPKD).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.
Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.
The clinical significance of caspase regulation in acute leukemia.
Prostatic Neoplasms
Caspase-2-Based Regulation of the Androgen Receptor and Cell Cycle in the Prostate Cancer Cell Line LNCaP.
Chronic administration of valproic acid inhibits prostate cancer cell growth in vitro and in vivo.
Docetaxel loaded oleic acid-coated hydroxyapatite nanoparticles enhance the docetaxel-induced apoptosis through activation of caspase-2 in androgen independent prostate cancer cells.
Dz13, a c-jun DNAzyme, Is a Potent Inducer of Caspase-2 Activation.
Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells.
Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells.
TSA-induced cell death in prostate cancer cell lines is caspase-2 dependent and involves the PIDDosome.
Rabies
BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein.
Reactivation of Nedd-2, a developmentally down-regulated apoptotic gene, in apoptosis induced by a street strain of rabies virus.
Reperfusion Injury
Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.
Retinal Degeneration
A sponge transgenic mouse model reveals important roles for the miRNA-183/96/182 cluster in post-mitotic photoreceptors of the retina.
Rhabdomyosarcoma
TRAIL-induced cytotoxicity in a melphalan-resistant rhabdomyosarcoma cell line via activation of caspase-2.
Seizures
Caspase-2 activation is redundant during seizure-induced neuronal death.
Small Cell Lung Carcinoma
Rescue from enhanced alkylator-induced cell death with low molecular weight sulfur-containing chemoprotectants.
TAp73alpha protects small cell lung carcinoma cells from caspase-2 induced mitochondrial mediated apoptotic cell death.
Stomach Neoplasms
Loss of caspase-2, -6 and -7 expression in gastric cancers.
Somatic mutations of caspase-2 gene in gastric and colorectal cancers.
Stroke
miR-1247-3p mediates apoptosis of cerebral neurons by targeting caspase-2 in stroke.
Tauopathies
Caspase-2 cleavage of tau reversibly impairs memory.
Telangiectasis
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3.
Thyroid Cancer, Papillary
Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
Thyroid Neoplasms
Study on the effect of integrin ???6 on the proliferation and apoptosis of thyroid carcinoma cells.
Tuberculosis
Immunogenicity and protective efficacy of a tuberculosis DNA vaccine co-expressing pro-apoptotic caspase-3.
Virus Diseases
[Relationship between hepatitis C virus infection and expression of apoptosis-related gene bcl-2, bax and ICH-1 in hepatocellular carcinoma tissues]