Reference on EC 3.4.22.53 - calpain-2

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dutt, P.; Springgs, C.N.; Davies, P.L.; Jia, Z.; Elce, J.S.
Origins of the difference in Ca2+ requirement for activation of mu- and m-calpain
Biochem. J.
367
263-269
2002
Rattus norvegicus
Manually annotated by BRENDA team
Emori, Y.; Kawasaki, H.; Sugihara, H.; Imajoh, S.; Kawashima, S.; Suzuki K.
Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent protease
J. Biol. Chem.
261
9465-9471
1986
Oryctolagus cuniculus (P06814)
Manually annotated by BRENDA team
Minami, Y.; Emori, Y.; Kawasaki, H.; Suzuki, K.
E-F hand structure-domain of calcium-activated neutral protease (CANP) can bind Ca2+ ions
J. Biochem.
101
889-895
1987
Oryctolagus cuniculus (P06814)
Manually annotated by BRENDA team
Sun, W.; Ji, S.Q.; Ebert, P.J.; Bidwell, C.A.; Hancock, D.L.
Cloning the partial cDNAs of mu-calpain and m-calpain from porcine skeletal muscle
Biochimie
75
931-936
1993
Sus scrofa (P43367), Sus scrofa
Manually annotated by BRENDA team
Nakajima, T.; Fukiage, C.; Azuma, M.; Ma, H.; Shearer, T.R.
Different expression patterns for ubiquitous calpains and Capn3 splice variants in monkey ocular tissues
Biochim. Biophys. Acta
1519
55-64
2001
Macaca fascicularis (Q9GLG1)
Manually annotated by BRENDA team
Murachi, T.; Tanaka, K.; Hatanaka, M.; Murakami, T.
Intracellular cellular Ca2+-dependent protease (calpain) and its high-molecular-weight endogenous inhibitor (calpastatin)
Adv. Enzyme Regul.
19
407-424
1981
Rattus norvegicus
Manually annotated by BRENDA team
Kishimoto, A.; Kajikawa, N.; Tabuchi, H.; Shiota, M.; Nishizuka, Y.
Calcium-dependent neutral proteases, widespread occurence of a species of protease active at lower concentrations of calcium
J. Biochem.
90
889-892
1981
Rattus norvegicus
Manually annotated by BRENDA team
Penny, I.F.; Taylor, M.A.J.; Harris, A.G.; Etherington, D.J.
Purification and immunological characterization of two calcium-activated neutral proteinases from rabbit skeletal muscle
Biochim. Biophys. Acta
829
244-252
1985
Oryctolagus cuniculus
Manually annotated by BRENDA team
Fukui, I.; Toyohara, H.; Ito, K.; Hamakubo, T.; Murachi, T.
Molecular and catalytic characterization of intact heterodimeric and derived monomeric calpains isolated under different conditions from pig polymorphonuclear leukocytes
Biochemistry
27
3260-3267
1988
Sus scrofa
Manually annotated by BRENDA team
Yoshimura, N.; Tsukahara, I.; Murachi, T.
Calpain and calpastatin in porcine retina
Biochem. J.
223
47-51
1984
Sus scrofa
Manually annotated by BRENDA team
Kitahara, A.; Sasaki, T.; Kikuchi, T.; Yumoto, N.; Yoshimura, N.; Hatanaka, M.; Murachi, T.
Large-scale purification of porcine calpain I and calpain II and comparison of proteolytic fragments of their subunits
J. Biochem.
95
1759-1766
1984
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Shastri, R.; Jagadeesh, G.; Anandaraj, M.P.J.S.
Human placental calcium activated neutral proteinase: Separation and functional characterization of subunits
J. Biosci.
15
427-434
1990
Homo sapiens
-
Manually annotated by BRENDA team
Murakami, T.; Ueda, M.; Hamakubo, T.; Murachi, T.
Identification of both calpains I and II in nucleated chicken erythrocytes
J. Biochem.
103
168-171
1988
Gallus gallus
Manually annotated by BRENDA team
Yoshimura, N.; Kikuchi, T.; Sasaki, T.; Kithara, A.; Hatanaka, M.; Murachi, T.
Two distinct Ca2+ proteases (calpain I and calpain II) purified concurrently by the same method from rat kidney
J. Biol. Chem.
258
8883-8889
1983
Rattus norvegicus
Manually annotated by BRENDA team
Inomata, M.; Nomoto, M.; Hayashi, M.; Nakamura, M.; Imahori, K.; Kawashima, S.
Comparison of low and high calcium requiring forms of the calcium-activated neutral protease (CANP) from rabbit skeletal muscle
J. Biochem.
95
1661-1670
1984
Oryctolagus cuniculus
Manually annotated by BRENDA team
Molinari, M.; maki, M.; Carafoli, E.
Purification of mu-calpain by a novel affinity chromatography approach. New insight into the mechanism of the interaction of the protease with targets
J. Biol. Chem.
270
14576-14581
1995
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, H.; Yamamoto, Y.; Shumiya, S.; Kunimatsu, M.; Nishi, K.; Ohkubo, I.; Kani, K.
Peptidases play an important role in cataractogenesis: an immunohistochemical study on lenses derived from Shumiya cataract rats
Histochem. J.
33
511-521
2002
Rattus norvegicus
Manually annotated by BRENDA team
Rojas, F.J.; Brush, M.; Moretti-Rojas, I.
Calpain-calpastatin: a novel, complete calcium-dependent protease system in human spermatozoa
Mol. Hum. Reprod.
5
520-526
1999
Homo sapiens
Manually annotated by BRENDA team
Sazontova, T.G.; Matskevich, A.A.; Arkhipenko, Y.V.
Calpains: physiological and pathophysiological significance
Pathophysiology
6
91-102
1999
Rattus norvegicus
-
Manually annotated by BRENDA team
Strobl S.; Fernandez-Catalan C.; Braun M.; Huber R.; Masumoto H.; Nakagawa K.; Irie A.; Sorimachi H.; Bourenkow G.; Bartunik H.; Suzuki K.; Bode W.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
Proc. Natl. Acad. Sci. USA
97
588-592
2000
Homo sapiens, Homo sapiens (P17655)
Manually annotated by BRENDA team
Imajoh S.; Aoki K.; Ohno S.; Emori Y.; Kawasaki H.; Sugihara H.; Suzuki K.
Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease
Biochemistry
27
8122-8128
1988
Homo sapiens (P17655)
Manually annotated by BRENDA team
Hata A.; Ohno S.; Akita Y.; Suzuki K.
Tandemly reiterated negative enhancer-like elements regulate transcription of a human gene for the large subunit of calcium-dependent protease
J. Biol. Chem.
264
6404-6411
1989
Homo sapiens (P17655)
Manually annotated by BRENDA team
Ye Z.; Connor J.R.
cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs
Biochem. Biophys. Res. Commun.
275
223-227
2000
Homo sapiens (P17655)
Manually annotated by BRENDA team
Strausberg R.L.; Feingold E.A.; Grouse L.H.; Derge J.G.; et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences
Proc. Natl. Acad. Sci. USA
99
16899-16903
2002
Homo sapiens (P17655)
Manually annotated by BRENDA team
Sorimachi H.; Tsukahara T.; Okada-Ban M.; Sugita H.; Ishiura S.; Suzuki K.
Identification of a third ubiquitous calpain species - chicken muscle expresses four distinct calpains
Biochim. Biophys. Acta
1261
381-393
1995
Gallus gallus (Q92178)
Manually annotated by BRENDA team
Deluca C.I.; Davies P.L.; Samis J.A.; Elce J.S.
Molecular cloning and bacterial expression of cDNA for rat calpain II 80 kDa subunit
Biochim. Biophys. Acta
1216
81-93
1993
Rattus norvegicus (Q07009)
Manually annotated by BRENDA team
Moldoveanu T.; Hosfield C.M.; Jia Z.; Elce J.S.; Davies P.L.
Ca2+-induced structural changes in rat m-calpain revealed by partial proteolysis
Biochim. Biophys. Acta
1545
245-254
2001
Rattus norvegicus (Q07009)
Manually annotated by BRENDA team
Arthur J.S.; Gauthier S.; Elce J.S.
Active site residues in m-calpain: identification by site-directed mutagenesis
FEBS Lett.
368
397-400
1995
Rattus norvegicus (Q07009)
Manually annotated by BRENDA team
Hosfield C.M.; Moldoveanu T.; Davies P.L.; Elce J.S.; Jia Z.
Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C2-like domain
J. Biol. Chem.
276
7404-7407
2001
Rattus norvegicus (Q07009), Rattus norvegicus
Manually annotated by BRENDA team
Hosfield C.M.; Elce J.S.; Davies P.L.; Jia Z.
Crystal structure of calpain reveals the structural basis for Ca2+-dependent protease activity and a novel mode of enzyme activation
EMBO J.
18
6880-6889
1999
Rattus norvegicus (Q07009)
Manually annotated by BRENDA team
Zhang J.L.; Patel J.M.; Block E.R.
Hypoxia-specific upregulation of calpain activity and gene expression in pulmonary artery endothelial cells
Am. J. Physiol.
275
L461-L468
1998
Sus scrofa (P43367)
Manually annotated by BRENDA team
Dear T.N.; Matena K.; Vingron M.; Boehm T.
A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution
Genomics
45
175-184
1997
Mus musculus, Mus musculus (O08529)
Manually annotated by BRENDA team
Hosfield, C.M.; Ye, Q.; Arthur, J.S.C.; Hegadorn, C.; Croall, D.E.; Elce, J.S.; Jia, Z.
Crystallization and X-ray crystallographic analysis of m-calpain, a Ca2+-dependent protease
Acta Crystallogr. Sect. D
55
1484-1486
1999
Rattus norvegicus
-
Manually annotated by BRENDA team
Wang, J.H.; Jiang, S.T.
Properties of calpain II from Tilapia muscle
Agric. Biol. Chem.
55
339-345
1991
Tilapia sp.
-
Manually annotated by BRENDA team
Sargianos, N.; Gaitanaki, C.; Beis, I.
Purification and characterization of m-calpain from the skeletal muscle of the amphibian Rana ridibunda
J. Exp. Zool.
269
95-105
1994
Pelophylax ridibundus
Manually annotated by BRENDA team
Elce, J.S.; Hegadorn, C.; Gauthier, S.; Vince, J.W.; Davies, P.L.
Recombinant calpain II: improved expression systems and production of a C105A active-site mutant for crystallography
Protein Eng.
8
843-848
1995
Rattus norvegicus
Manually annotated by BRENDA team
Masumoto, H.; Yoshizawa, T.; Sorimachi, H.; Nishino, T.; Ishiura, S.; Suzuki, K.
Overexpression, purification, and characterization of human m-calpain and its active site mutant, m-C105S-calpain, using a baculovirus expression system
J. Biochem.
124
957-961
1998
Homo sapiens
Manually annotated by BRENDA team
Azarian, S.M.; Schlamp, C.L.; Williams, D.S.
Characterization of calpain II in the retina and photoreceptor outer segments
J. Cell Sci.
105
787-798
1993
Bos taurus
-
Manually annotated by BRENDA team
Wang, J.H.; Ma, W.C.; Su, J.C.; Chen, C.S.; Jiang, S.T.
Comparison of the properties of m-calpain from Tilapia and grass shrimp muscles
J. Agric. Food Chem.
41
1379-1384
1993
Penaeus monodon, Tilapia sp.
Manually annotated by BRENDA team
Hirao, T.; Takahashi, K.
Purification and characterization of a calcium-activated neutral protease from monkey brain and its action on neuropeptides
J. Biochem.
96
775-784
1984
Macaca fuscata
Manually annotated by BRENDA team
Dourdin, N.; Balcerzak, D.; Brustis, J.J.; Poussard, S.; Cottin, P.; Ducastaing, A.
Potential m-calpain substrates during myoblast fusion
Exp. Cell Res.
246
433-442
1999
Oryctolagus cuniculus
Manually annotated by BRENDA team
Ojha, M.; Barja, F.
Spatial and cellular localization of calcium-dependent protease (CDP II) in Allomyces arbuscula
J. Cell Sci.
116
1095-1105
2003
Allomyces arbusculus
Manually annotated by BRENDA team
Mkwetshana, N.; Naude, R.J.; Oelofsen, W.; Muramoto, K.; Naganuma, T.
The purification and characterization of m-calpain from ostrich brain
Int. J. Biochem. Cell Biol.
34
337-347
2002
Struthio camelus
Manually annotated by BRENDA team
Smith, S.D.; Jia, Z.; Huynh, K.K.; Wells, A.; Elce, J.S.
Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation
FEBS Lett.
542
115-118
2003
Rattus norvegicus
Manually annotated by BRENDA team
Glading, A.; Chang, P.; Lauffenburger, D.A.; Wells, A.
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway
J. Biol. Chem.
275
2390-2398
2000
Mus musculus
Manually annotated by BRENDA team
Han, Y.; Weinman, S.; Boldogh, I.; Walker, R.K.; Brasier, A.R.
Tumor necrosis factor-a-inducible I.kappa.Ba proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kB activation
J. Biol. Chem.
274
787-794
1999
Oryctolagus cuniculus
Manually annotated by BRENDA team
Dedieu, S.; Mazeres, G.; Dourdin, N.; Cottin, P.; Brustis, J.J.
Transactivation of capn2 by Myogenic Regulatory Factors During Myogenesis
J. Mol. Biol.
326
453-465
2003
Homo sapiens
Manually annotated by BRENDA team
Ladrat, C.; Verrez-Bagnis, V.; Noel, J.; Fleurence, J.
Milli-calpain from sea bass (Dicentrarchus labrax) white muscle: purification, characterization of its activity and activation in vitro
Mar. Biotechnol.
4
51-62
2002
Dicentrarchus labrax
Manually annotated by BRENDA team
Kawai, K.; Fujimoto, K.; Okamoto, A.; Inaba, A.; Yamada, H.; Katoh, S.
Transient activation of dihydropteridine reductase by Ca2+-activated proteolysis
Zool. Sci.
17
437-443
2000
Ovis aries
-
Manually annotated by BRENDA team
Hata, S.; Koyama, S.; Kawahara, H.; Doi, N.; Maeda, T.; Toyama-Sorimachi, N.; Abe, K.; Suzuki, K.; Sorimachi, H.
Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP
J. Biol. Chem.
281
11214-11224
2006
Mus musculus
Manually annotated by BRENDA team
Veerann, V.; Kaji, T.; Boland, B.; Odrljin, T.; Mohan, P.; Basavarajappa, B.S.; Peterhoff, C.; Cataldo, A.; Rudnicki, A.; Amin, N.; Li, B.S.; Pant, H.C.; Hungund, B.L.; Arancio, O.; Nixon, R.A.
Calpain mediates calcium-induced activation of the Erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: Relevance to Alzheimers disease
Am. J. Pathol.
165
795-805
2004
Homo sapiens
Manually annotated by BRENDA team
Azuma, M.; Tamada, Y.; Kanaami, S.; Nakajima, E.; Nakamura, Y.; Fukiage, C.; Forsberg, N.E.; Duncan, M.K.; Shearer, T.R.
Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins
Biochem. Biophys. Res. Commun.
307
558-563
2003
Mus musculus
Manually annotated by BRENDA team
Li, H.; Thompson, V.F.; Goll, D.E.
Effects of autolysis on properties of mu- and m-calpain
Biochim. Biophys. Acta
1691
91-103
2004
Homo sapiens
Manually annotated by BRENDA team
Inserte, J.; Garcia-Dorado, D.; Hernando, V.; Soler-Soler, J.
Calpain-mediated impairment of Na+/K+-ATPase activity during early reperfusion contributes to cell death after myocardial ischemia
Circ. Res.
97
465-473
2005
Rattus norvegicus
Manually annotated by BRENDA team
Carragher, N.O.
Calpain inhibition: a therapeutic strategy targeting multiple disease states
Curr. Pharm. Des.
12
615-638
2006
Homo sapiens, Homo sapiens (P07384)
Manually annotated by BRENDA team
Franco, S.; Perrin, B.; Huttenlocher, A.
Isoform specific function of calpain 2 in regulating membrane protrusion
Exp. Cell Res.
299
179-187
2004
Mus musculus
Manually annotated by BRENDA team
Reed, N.A.; Castellini, M.A.; Ma, H.; Shearer, T.R.; Duncan, M.K.
Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens
Exp. Eye Res.
76
433-443
2003
Mus musculus
Manually annotated by BRENDA team
Maddock, K.R.; Huff-Lonergan, E.; Rowe, L.J.; Lonergan, S.M.
Effect of pH and ionic strength on mu- and m-calpain inhibition by calpastatin
J. Anim. Sci.
83
1370-1376
2005
Sus scrofa
Manually annotated by BRENDA team
Carlin, K.R.; Huff-Lonergan, E.; Rowe, L.J.; Lonergan, S.M.
Effect of oxidation, pH, and ionic strength on calpastatin inhibition of mu- and m-calpain
J. Anim. Sci.
84
925-937
2006
Sus scrofa
Manually annotated by BRENDA team
Shao, H.; Chou, J.; Baty, C.J.; Burke, N.A.; Watkins, S.C.; Stolz, D.B.; Wells, A.
Spatial localization of m-calpain to the plasma membrane by phosphoinositide biphosphate binding during epidermal growth factor receptor-mediated activation
Mol. Cell. Biol.
26
5481-5496
2006
Mus musculus
Manually annotated by BRENDA team
Vermaelen, M.; Sirvent, P.; Raynaud, F.; Astier, C.; Mercier, J.; Lacampagne, A.; Cazorla, O.
Differential localization of autolyzed calpains 1 and 2 in slow and fast skeletal muscles in the early phase of atrophy
Am. J. Physiol.
292
C1723-C1731
2007
Rattus norvegicus
Manually annotated by BRENDA team
Camou, J.P.; Marchello, J.A.; Thompson, V.F.; Mares, S.W.; Goll, D.E.
Effect of postmortem storage on activity of mu- and m-calpain in five bovine muscles
J. Anim. Sci.
85
2670-2681
2007
Bos taurus
Manually annotated by BRENDA team
Upla, P.; Marjomaeki, V.; Nissinen, L.; Nylund, C.; Waris, M.; Hyypiae, T.; Heino, J.
Calpain 1 and 2 are required for RNA replication of echovirus 1
J. Virol.
82
1581-1590
2008
Homo sapiens
Manually annotated by BRENDA team
Miyazaki, T.; Honda, K.; Ohata, H.
Requirement of Ca2+ influx- and phosphatidylinositol 3-kinase-mediated m-calpain activity for shear stress-induced endothelial cell polarity
Am. J. Physiol.
293
C1216-C1225
2007
Homo sapiens
Manually annotated by BRENDA team
Samanta, K.; Kar, P.; Ghosh, B.; Chakraborti, T.; Chakraborti, S.
Localization of m-calpain and calpastatin and studies of their association in pulmonary smooth muscle endoplasmic reticulum
Biochim. Biophys. Acta
1770
1297-1307
2007
Bos taurus
Manually annotated by BRENDA team
Dutt, P.; Croall, D.E.; Arthur, J.S.; De Veyra, T.; Williams, K.; Elce, J.S.; Greer, P.A.
m-Calpain is required for preimplantation embryonic development in mice
BMC Dev. Biol.
6
0000
2006
Mus musculus, Mus musculus (O08529)
Manually annotated by BRENDA team
Shanmuga Sundaram, J.; Mohana Rao, V.; Meena, A.K.; Anandaraj, M.P.
Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy
Clin. Chim. Acta
373
82-87
2006
Homo sapiens
Manually annotated by BRENDA team
Su, Y.; Cui, Z.; Li, Z.; Bloc, E.R.
Calpain-2 regulation of VEGF-mediated angiogenesis
FASEB J.
20
1443-1451
2006
Homo sapiens
Manually annotated by BRENDA team
Raynaud, F.; Marcilhac, A.; Chebli, K.; Benyamin, Y.; Rossel, M.
Calpain 2 expression pattern and sub-cellular localization during mouse embryogenesis
Int. J. Dev. Biol.
52
383-388
2008
Mus musculus
Manually annotated by BRENDA team
Camou, J.P.; Mares, S.W.; Marchello, J.A.; Vazquez, R.; Taylor, M.; Thompson, V.F.; Goll, D.E.
Isolation and characterization of mu-calpain, m-calpain, and calpastatin from postmortem muscle. I. Initial steps
J. Anim. Sci.
85
3400-3414
2007
Bos taurus
Manually annotated by BRENDA team
Maehara, H.; Suzuki, K.; Sasaki, T.; Oshita, H.; Wada, E.; Inoue, T.; Shimizu, K.
G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage
J. Biochem.
141
469-477
2007
Homo sapiens
Manually annotated by BRENDA team
Sanchez-Sanchez, F.; Martinez-Redondo, F.; Aroca-Aguilar, J.D.; Coca-Prados, M.; Escribano, J.
Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease
J. Biol. Chem.
282
27810-27824
2007
Homo sapiens
Manually annotated by BRENDA team
Mellgren, R.L.; Huang, X.
Fetuin A stabilizes m-calpain and facilitates plasma membrane repair
J. Biol. Chem.
282
35868-35877
2007
Bos taurus
Manually annotated by BRENDA team
Cortesio, C.L.; Chan, K.T.; Perrin, B.J.; Burton, N.O.; Zhang, S.; Zhang, Z.Y.; Huttenlocher, A.
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion
J. Cell Biol.
180
957-971
2008
Homo sapiens
Manually annotated by BRENDA team
Zakharov, V.V.; Mosevitsky, M.I.
M-calpain-mediated cleavage of GAP-43 near Ser41 is negatively regulated by protein kinase C, calmodulin and calpain-inhibiting fragment GAP-43-3
J. Neurochem.
101
1539-1551
2007
Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Nuzzi, P.A.; Senetar, M.A.; Huttenlocher, A.
Asymmetric localization of calpain 2 during neutrophil chemotaxis
Mol. Biol. Cell
18
795-805
2007
Homo sapiens
Manually annotated by BRENDA team
Qiu, K.; Su, Y.; Block, E.R.
Use of recombinant calpain-2 siRNA adenovirus to assess calpain-2 modulation of lung endothelial cell migration and proliferation
Mol. Cell. Biochem.
292
69-78
2006
Homo sapiens
Manually annotated by BRENDA team
Honda, M.; Masui, F.; Kanzawa, N.; Tsuchiya, T.; Toyo-oka, T.
Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi
Am. J. Physiol. Cell Physiol.
294
C957-C965
2008
Mus musculus
Manually annotated by BRENDA team
Garnham, C.; Hanna, R.; Chou, J.; Low, K.; Gourlay, K.; Campbell, R.; Beckmann, J.; Davies, P.
Limb-girdle muscular dystrophy type 2A can result from accelerated autoproteolytic inactivation of calpain 3
Biochemistry
48
3457-3467
2009
Homo sapiens (P04632), Rattus norvegicus (Q07009)
Manually annotated by BRENDA team
Grossi, A.; Karlsson, A.H.; Lawson, M.A.
Mechanical stimulation of C2C12 cells increases m-calpain expression, focal adhesion plaque protein degradation
Cell Biol. Int.
32
615-622
2008
Mus musculus
Manually annotated by BRENDA team
Vissing, K.; Overgaard, K.; Nedergaard, A.; Fredsted, A.; Schjerling, P.
Effects of concentric and repeated eccentric exercise on muscle damage and calpain-calpastatin gene expression in human skeletal muscle
Eur. J. Appl. Physiol.
103
323-332
2008
Homo sapiens, Homo sapiens (P17655)
Manually annotated by BRENDA team
Bevers, M.B.; Lawrence, E.; Maronski, M.; Starr, N.; Amesquita, M.; Neumar, R.W.
Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity
J. Neurochem.
108
1237-1250
2009
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, L.; Ma, B.; Wu, J.; Fei, C.; Yang, L.; Wan, H.
Cloning and characterization of the yak gene coding for calpastatin and in silico analysis of its putative product
Acta Biochim. Pol.
57
35-41
2010
Bos mutus
Manually annotated by BRENDA team
Babbin, B.A.; Koch, S.; Bachar, M.; Conti, M.A.; Parkos, C.A.; Adelstein, R.S.; Nusrat, A.; Ivanov, A.I.
Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion
Am. J. Pathol.
174
436-448
2009
Homo sapiens
Manually annotated by BRENDA team
Kar, P.; Samanta, K.; Shaikh, S.; Chowdhury, A.; Chakraborti, T.; Chakraborti, S.
Mitochondrial calpain system: an overview
Arch. Biochem. Biophys.
495
1-7
2010
Rattus norvegicus
Manually annotated by BRENDA team
Wang, H.C.; Huang, Y.S.; Ho, C.C.; Jeng, J.C.; Shih, H.M.
SUMO modification modulates the activity of calpain-2
Biochem. Biophys. Res. Commun.
384
444-449
2009
Homo sapiens
Manually annotated by BRENDA team
Janssens, V.; Derua, R.; Zwaenepoel, K.; Waelkens, E.; Goris, J.
Specific regulation of protein phosphatase 2A PR72/B'' subunits by calpain
Biochem. Biophys. Res. Commun.
386
676-681
2009
Rattus norvegicus
Manually annotated by BRENDA team
Nakada, S.; Tsuneyama, K.; Kato, I.; Tabuchi, Y.; Takasaki, I.; Furusawa, Y.; Kawaguchi, H.; Fujimoto, M.; Goto, H.; Hikiami, H.; Kondo, T.; Takano, Y.; Shimada, Y.
Identification of candidate genes involved in endogenous protection mechanisms against acute pancreatitis in mice
Biochem. Biophys. Res. Commun.
391
1342-1347
2010
Mus musculus
Manually annotated by BRENDA team
Ozaki, T.; Yamashita, T.; Ishiguro, S.
Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria
Biochim. Biophys. Acta
1793
1848-1859
2009
Rattus norvegicus
Manually annotated by BRENDA team
Meng, X.N.; Jin, Y.; Yu, Y.; Bai, J.; Liu, G.Y.; Zhu, J.; Zhao, Y.Z.; Wang, Z.; Chen, F.; Lee, K.Y.; Fu, S.B.
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion
Br. J. Cancer
101
327-334
2009
Homo sapiens
Manually annotated by BRENDA team
Barbero, S.; Mielgo, A.; Torres, V.; Teitz, T.; Shields, D.J.; Mikolon, D.; Bogyo, M.; Barila, D.; Lahti, J.M.; Schlaepfer, D.; Stupack, D.G.
Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis
Cancer Res.
69
3755-3763
2009
Homo sapiens
Manually annotated by BRENDA team
Miyazaki, T.; Honda, K.; Ohata, H.
m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions
Cardiovasc. Res.
85
530-541
2010
Mus musculus
Manually annotated by BRENDA team
Lemke, A.K.; Sandy, J.D.; Voigt, H.; Dreier, R.; Lee, J.H.; Grodzinsky, A.J.; Mentlein, R.; Fay, J.; Schuenke, M.; Kurz, B.
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2
Cell Tissue Res.
340
179-188
2010
Bos taurus
Manually annotated by BRENDA team
Liu, S.H.; Yang, C.N.; Pan, H.C.; Sung, Y.J.; Liao, K.K.; Chen, W.B.; Lin, W.Z.; Sheu, M.L.
IL-13 downregulates PPAR-gamma/heme oxygenase-1 via ER stress-stimulated calpain activation: aggravation of activated microglia death
Cell. Mol. Life Sci.
67
1465-1476
2010
Rattus norvegicus
Manually annotated by BRENDA team
Magnaghi-Jaulin, L.; Marcilhac, A.; Rossel, M.; Jaulin, C.; Benyamin, Y.; Raynaud, F.
Calpain 2 is required for sister chromatid cohesion
Chromosoma
119
267-274
2010
Mus musculus
Manually annotated by BRENDA team
Pilop, C.; Aregger, F.; Gorman, R.C.; Brunisholz, R.; Gerrits, B.; Schaffner, T.; Gorman, J.H.; Matyas, G.; Carrel, T.; Frey, B.M.
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms
Circulation
120
983-991
2009
Homo sapiens
Manually annotated by BRENDA team
Arroba, A.I.; Wallace, D.; Mackey, A.; de la Rosa, E.J.; Cotter, T.G.
IGF-I maintains calpastatin expression and attenuates apoptosis in several models of photoreceptor cell death
Eur. J. Neurosci.
30
975-986
2009
Mus musculus
Manually annotated by BRENDA team
Roumes, H.; Leloup, L.; Dargelos, E.; Brustis, J.J.; Daury, L.; Cottin, P.
Calpains: markers of tumor aggressiveness?
Exp. Cell Res.
316
1587-1599
2010
Homo sapiens
Manually annotated by BRENDA team
Macqueen, D.J.; Meischke, L.; Manthri, S.; Anwar, A.; Solberg, C.; Johnston, I.A.
Characterisation of capn1, capn2-like, capn3 and capn11 genes in Atlantic halibut (Hippoglossus hippoglossus L.): Transcriptional regulation across tissues and in skeletal muscle at distinct nutritional states
Gene
453
45-58
2010
Hippoglossus hippoglossus (D2IKJ8), Hippoglossus hippoglossus
Manually annotated by BRENDA team
Weber, H.; Huehns, S.; Luethen, F.; Jonas, L.
Calpain-mediated breakdown of cytoskeletal proteins contributes to cholecystokinin-induced damage of rat pancreatic acini
Int. J. Exp. Pathol.
90
387-399
2009
Rattus norvegicus
Manually annotated by BRENDA team
Samanta, K.; Kar, P.; Chakraborti, T.; Chakraborti, S.
Calcium-dependent cleavage of the Na+/Ca2+ exchanger by m-calpain in isolated endoplasmic reticulum
J. Biochem.
147
225-235
2010
Bos taurus
Manually annotated by BRENDA team
Samanta, K.; Kar, P.; Chakraborti, T.; Shaikh, S.; Chakraborti, S.
Characteristic properties of endoplasmic reticulum membrane m-calpain, calpastatin and lumen m-calpain: a comparative study between membrane and lumen m-calpains
J. Biochem.
147
765-779
2010
Bos taurus
Manually annotated by BRENDA team
Rudinskiy, N.; Grishchuk, Y.; Vaslin, A.; Puyal, J.; Delacourte, A.; Hirling, H.; Clarke, P.G.; Luthi-Carter, R.
Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration
J. Biol. Chem.
284
12447-12458
2009
Rattus norvegicus
Manually annotated by BRENDA team
Lin, I.J.; Zhou, Z.; Crusselle-Davis, V.J.; Moghimi, B.; Gandhi, K.; Anantharaman, A.; Pantic, D.; Huang, S.; Jayandharan, G.; Zhong, L.; Srivastava, A.; Bungert, J.
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells
J. Biol. Chem.
284
20130-20135
2009
Mus musculus
Manually annotated by BRENDA team
Chan, K.T.; Bennin, D.A.; Huttenlocher, A.
Regulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK)
J. Biol. Chem.
285
11418-11426
2010
Rattus norvegicus
Manually annotated by BRENDA team
Chen, H.; Libertini, S.J.; Wang, Y.; Kung, H.J.; Ghosh, P.; Mudryj, M.
ERK regulates calpain 2-induced androgen receptor proteolysis in CWR22 relapsed prostate tumor cell lines
J. Biol. Chem.
285
2368-2374
2010
Homo sapiens
Manually annotated by BRENDA team
Lizama, C.; Lagos, C.F.; Lagos-Cabre, R.; Cantuarias, L.; Rivera, F.; Huenchunir, P.; Perez-Acle, T.; Carrion, F.; Moreno, R.D.
Calpain inhibitors prevent p38 MAPK activation and germ cell apoptosis after heat stress in pubertal rat testes
J. Cell. Physiol.
221
296-305
2009
Rattus norvegicus
Manually annotated by BRENDA team
Liu, Z.; Wang, S.; Zhou, H.; Yang, Y.; Zhang, M.
Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL
J. Gastroenterol. Hepatol.
24
879-885
2009
Homo sapiens
Manually annotated by BRENDA team
Su, L.T.; Chen, H.C.; Gonzalez-Pagan, O.; Overton, J.D.; Xie, J.; Yue, L.; Runnels, L.W.
TRPM7 activates m-calpain by stress-dependent stimulation of p38 MAPK and c-Jun N-terminal kinase
J. Mol. Biol.
396
858-869
2010
Homo sapiens
Manually annotated by BRENDA team
Hernando, V.; Inserte, J.; Sartorio, C.L.; Parra, V.M.; Poncelas-Nozal, M.; Garcia-Dorado, D.
Calpain translocation and activation as pharmacological targets during myocardial ischemia/reperfusion
J. Mol. Cell. Cardiol.
49
271-279
2010
Rattus norvegicus
Manually annotated by BRENDA team
Zadran, S.; Jourdi, H.; Rostamiani, K.; Qin, Q.; Bi, X.; Baudry, M.
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation
J. Neurosci.
30
1086-1095
2010
Homo sapiens
Manually annotated by BRENDA team
Ma, H.; Tochigi, A.; Shearer, T.R.; Azuma, M.
Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells
J. Ocul. Pharmacol. Ther.
25
409-414
2009
Homo sapiens
Manually annotated by BRENDA team
Toke, O.; Banoczi, Z.; Tarkanyi, G.; Friedrich, P.; Hudecz, F.
Folding transitions in calpain activator peptides studied by solution NMR spectroscopy
J. Pept. Sci.
15
404-410
2009
Rattus norvegicus
Manually annotated by BRENDA team
Juszczuk-Kubiak, E.; Flisikowski, K.; Wicinska, K.; Poloszynowicz, J.; Rosochacki, S.
Identification of the new polymorphisms in the promoter region of the CAST gene in cattle
Meat Sci.
82
278-283
2009
Bos taurus
Manually annotated by BRENDA team
Cortesio, C.L.; Perrin, B.J.; Bennin, D.A.; Huttenlocher, A.
Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation
Mol. Biol. Cell
21
186-197
2010
Rattus norvegicus
Manually annotated by BRENDA team
Shaikh, S.; Samanta, K.; Kar, P.; Roy, S.; Chakraborti, T.; Chakraborti, S.
m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle
Mol. Cell. Biochem.
341
167-180
2010
Bos taurus
Manually annotated by BRENDA team
Liu, W.; Zhou, X.W.; Liu, S.; Hu, K.; Wang, C.; He, Q.; Li, M.
Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons
Proteomics
9
3712-3728
2009
Rattus norvegicus
Manually annotated by BRENDA team
Ozaki, T.; Yamashita, T.; Ishiguro, S.
Ca2+-induced release of mitochondrial m-calpain from outer membrane with binding of calpain small subunit and Grp75
Arch. Biochem. Biophys.
507
254-261
2011
Rattus norvegicus
Manually annotated by BRENDA team
Gaarder, M.; Thomassen, M.; Veiseth-Kent, E.
Identification of calpastatin, ?-calpain and m-calpain in Atlantic salmon (Salmo salar L.) muscle
Food Chem.
125
1091-1096
2011
Salmo salar
Manually annotated by BRENDA team
Kim, Y.; Huff-Lonergan, E.; Lonergan, S.
Effect of calcium lactate on m-calpain activity and protein degradation under oxidising conditions
Food Chem.
131
73-78
2012
Sus scrofa
-
Manually annotated by BRENDA team
Silver, K.; Leloup, L.; Freeman, L.C.; Wells, A.; Lillich, J.D.
Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease
Int. J. Biochem. Cell Biol.
42
2030-2036
2010
Mus musculus
Manually annotated by BRENDA team
Huang, C.; Gurlo, T.; Haataja, L.; Costes, S.; Daval, M.; Ryazantsev, S.; Wu, X.; Butler, A.; Butler, P.
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes
J. Biol. Chem.
285
339-348
2010
Rattus norvegicus
Manually annotated by BRENDA team
Huang, Z.; Hoffmann, F.W.; Norton, R.L.; Hashimoto, A.C.; Hoffmann, P.R.
Selenoprotein K is a novel target of m-calpain, and cleavage is regulated by Toll-like receptor-induced calpastatin in macrophages
J. Biol. Chem.
286
34830-34838
2011
Sus scrofa
Manually annotated by BRENDA team
Ovat, A.; Li, Z.; Hampton, C.; Asress, S.; Fernandez, F.; Glass, J.; Powers, J.
Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors
J. Med. Chem.
53
6326-6336
2010
Sus scrofa
Manually annotated by BRENDA team
Jang, H.S.; Lal, S.; Greenwood, J.A.
Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2
Neurochem. Res.
35
1796-1804
2010
Homo sapiens
Manually annotated by BRENDA team
Svensson, L.; McDowall, A.; Giles, K.M.; Stanley, P.; Feske, S.; Hogg, N.
Calpain 2 controls turnover of LFA-1 adhesions on migrating T lymphocytes
PLoS ONE
5
e15090
2010
Homo sapiens
Manually annotated by BRENDA team
Prangsaengtong, O.; Senda, K.; Doki, Y.; Park, J.Y.; Jo, M.; Sakurai, H.; Shibahara, N.; Saiki, I.; Koizumi, K.
Calpain 1 and -2 play opposite roles in cord formation of lymphatic endothelial cells via eNOS regulation
Hum. Cell
25
36-44
2012
Homo sapiens
Manually annotated by BRENDA team
Ho, W.C.; Pikor, L.; Gao, Y.; Elliott, B.E.; Greer, P.A.
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma
J. Biol. Chem.
287
15458-15465
2012
Mus musculus
Manually annotated by BRENDA team
Lal, S.; La Du, J.; Tanguay, R.; Greenwood, J.
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment
J. Neurosci. Res.
90
769-781
2012
Danio rerio
Manually annotated by BRENDA team
Banoczi, Z.; Tantos, A.; Farkas, A.; Majer, Z.; Dokus, L.E.; Tompa, P.; Hudecz, F.
New m-calpain substrate-based azapeptide inhibitors
J. Pept. Sci.
19
370-376
2013
Rattus norvegicus
Manually annotated by BRENDA team
Santos, D.M.; Xavier, J.M.; Morgado, A.L.; Sola, S.; Rodrigues, C.M.
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation
PLoS ONE
7
e33468
2012
Mus musculus
Manually annotated by BRENDA team