Disease on EC 3.4.22.53 - calpain-2

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DISEASE
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Acidosis
Influence of glutamine infusion on ubiquitin, caspase-3, cathepsins L and B, and m-calpain expression in sheep with nutritionally induced metabolic acidosis.
Adenocarcinoma
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Overexpression of m-calpain in human colorectal adenocarcinomas.
Alzheimer Disease
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases.
Hypoxia-Triggered m-Calpain Activation Evokes Endoplasmic Reticulum Stress and Neuropathogenesis in a Transgenic Mouse Model of Alzheimer's Disease.
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.
m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease.
The calpain family and human disease.
Anthrax
Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis.
Aortic Aneurysm
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms.
Aortic Aneurysm, Abdominal
Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice.
Arsenic Poisoning
[Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25].
Arthritis
Appearance of calpain correlates with arthritis and cartilage destruction in collagen induced arthritic knee joints of mice.
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Arthritis, Rheumatoid
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Astrocytoma
Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2.
Ataxia
Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.
Atherosclerosis
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.
Atrial Fibrillation
[Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation].
Blindness
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.
Brain Injuries
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Injuries, Traumatic
Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo.
Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Erratum to: Degradation of ?II-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat.
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Ischemia
Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia.
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia.
Breast Neoplasms
Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Calpain system protein expression in basal-like and triple-negative invasive breast cancer.
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype.
Cytoplasmic FOXP1 expression is correlated with ER and calpain II expression and predicts a poor outcome in breast cancer.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics.
Hyperactivated m-calpain affects acquisition of doxorubicin resistance in breast cancer cells.
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Brucellosis
Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.
calpain-2 deficiency
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Genetic Models of Calpain Deficiency and Ectopic Expression.
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Carcinogenesis
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Carcinoma
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Calpain system protein expression and activity in ovarian cancer.
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration.
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Carcinoma, Hepatocellular
Apoptosis by aloe-emodin is mediated through downregulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells.
Calpains are required for invasive and metastatic potentials of human HCC cells.
Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Cardiomegaly
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
Cardiomyopathies
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Cardiotoxicity
Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2.
Cataract
Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse.
alpha-Crystallin chaperone activity is reduced by calpain II in vitro and in selenite cataract.
Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract.
Buthionine sulfoximine induced cataracts in mice contain insolubilized crystallins with calpain II cleavage sites.
Calpain II in human lens.
Calpain II in two in vivo models of sugar cataract.
Calpain II induced insolubilization of lens beta-crystallin polypeptides may induce cataract.
Calpains and their multiple roles in diabetes mellitus.
Calpains in lens epithelium from patients with cataract.
Cataract and the acceleration of calpain-induced beta-crystallin insolubilization occurring during normal maturation of rat lens.
Changes in calpain II mRNA in young rat lens during maturation and cataract formation.
Comparison of Lp82- and m-calpain-mediated proteolysis during cataractogenesis in Shumiya cataract rat (SCR).
Contribution of calpain Lp82-induced proteolysis to experimental cataractogenesis in mice.
Evidence for apoptosis in the selenite rat model of cataract.
General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice.
Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.
Involvement of calpain 2 in ionomycin-induced cell death in cultured mouse lens epithelial cells.
Loss of calpastatin leads to activation of calpain in human lens epithelial cells.
Lp85 calpain is an enzymatically active rodent-specific isozyme of lens Lp82.
Mass measurements of C-terminally truncated alpha-crystallins from two-dimensional gels identify Lp82 as a major endopeptidase in rat lens.
Modifications to rat lens major intrinsic protein in selenite-induced cataract.
Origin of urea-soluble protein in the selenite cataract. Role of beta-crystallin proteolysis and calpain II.
Prevention and reversal of selenite-induced cataracts by N-acetylcysteine amide in Wistar rats.
Protein for Lp82 calpain is expressed and enzymatically active in young rat lens.
Purification of calpain II from rat lens and determination of endogenous substrates.
Regional distribution of free calcium in selenite cataract: relation to calpain II.
Role of calpains in diabetes mellitus-induced cataractogenesis: a mini review.
[The expression of calpain II in rat lens epithelial cells of hydrogen peroxide-induced cataract]
Colitis
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Colonic Neoplasms
Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.
Colorectal Neoplasms
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.
Correction: New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Overexpression of m-calpain in human colorectal adenocarcinomas.
Craniocerebral Trauma
Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
Diabetes Mellitus, Type 2
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.
Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes.
Structure, activation, and biology of calpain.
Down Syndrome
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Endometrial Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.
Eye Abnormalities
General utility of the chicken betaB1-crystallin promoter to drive protein expression in lens fiber cells of transgenic mice.
Glioblastoma
Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2.
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment.
Granuloma
Cellular distribution of proteolytic enzymes in the skeletal muscle of sarcoid myopathy.
Head Injuries, Closed
Attenuation of microtubule associated protein-2 degradation after mild head injury by mexiletine and calpain-2 inhibitor.
Heart Failure
betaARK1 inhibition improves survival in a mouse model of heart failure induced by myocardial infarction.
Heart Valve Diseases
[Calpain-2 and calcineurin protein expression in right atrial appendages from patients underwent valve replacement with or without atrial fibrillation].
Hyperalgesia
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Hyperglycemia
Somatostatin protects photoreceptor cells against high glucose-induced apoptosis.
Hyperinsulinism
Euglycemic hyperinsulinemia and hyperaminoacidemia decrease skeletal muscle ubiquitin mRNA in goats.
Hypersensitivity
Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12.
Hypertension
Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.
Hypertension, Pulmonary
Calcium-dependent cleavage of the Na(+)/Ca(2+) exchanger by m-calpain in isolated endoplasmic reticulum.
m-Calpain-mediated cleavage of Na(+)/Ca (2+) exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle.
Hypertension, Renovascular
Transcriptional regulation of calcium-activated neutral protease in cardiomyocytes of hypertensive rats.
Infection
Calpain 1 and 2 are required for RNA replication of echovirus 1.
Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I.
Inflammatory Breast Neoplasms
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Leukemia
Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines.
Leukemia, T-Cell
Expression of calpain II gene in human hematopoietic system cells infected with human T-cell leukemia virus type I.
Leukemia-Lymphoma, Adult T-Cell
Gene expression for calpain isozymes in human hematopoietic system cells.
Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia.
Lung Neoplasms
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Characterisation of fibronectin-mediated FAK signalling pathways in lung cancer cell migration and invasion.
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Malaria
Cerebral calpain in fatal falciparum malaria.
Marfan Syndrome
Proteomic analysis in aortic media of patients with Marfan syndrome reveals increased activity of calpain 2 in aortic aneurysms.
Memory Disorders
Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.
Muscle Spasticity
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery.
Muscular Atrophy
Daily variations in dietary lysine content alter the expression of genes related to proteolysis in chicken pectoralis major muscle.
Gene expression of proteolytic systems and growth regulators of skeletal muscle in horses with myopathy associated with pituitary pars intermedia dysfunction.
Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats.
Muscular Dystrophies
Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain.
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.
Muscular Dystrophies, Limb-Girdle
Mutations in calpain 3 associated with limb girdle muscular dystrophy: analysis by molecular modeling and by mutation in m-calpain.
Muscular Dystrophy, Duchenne
Altered expression, intracellular distribution and activity of lymphocyte calpain II in Duchenne muscular dystrophy.
Deletion analysis & calpain status for carrier detection in a family with Duchenne muscular dystrophy.
Platelet m-calpain: a facile marker and STR polymorphism analysis for the identification of true carriers of Duchenne muscular dystrophy.
Quantitative ELISA for platelet m-calpain: a phenotypic index for detection of carriers of Duchenne muscular dystrophy.
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.
Myocardial Infarction
betaARK1 inhibition improves survival in a mouse model of heart failure induced by myocardial infarction.
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Neoplasm Metastasis
Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway.
Calpains are required for invasive and metastatic potentials of human HCC cells.
Neoplasms
Apoptosis-related genes change their expression with age and hearing loss in the mouse cochlea.
Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function.
Calpain 2 is required for the invasion of glioblastoma cells in the zebrafish brain microenvironment.
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss.
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Calpain-2 as a target for limiting prostate cancer invasion.
Calpain-2 Enhances Non-Small Cell Lung Cancer Progression and Chemoresistance to Paclitaxel via EGFR-pAKT Pathway.
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.
Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme.
Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Calpain-3 gene expression is decreased during experimental cancer cachexia.
Calpains are required for invasive and metastatic potentials of human HCC cells.
Epigallocatechin-3-gallate pretreatment attenuates doxorubicin-induced cardiotoxicity in rats: A mechanistic study.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Human U87 astrocytoma cell invasion induced by interaction of ?ig-h3 with integrin ?5?1 involves calpain-2.
Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Integrin ?6 and EGFR signaling converge at mechanosensitive calpain 2.
Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity.
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Novel Bioinformatics-Based Approach for Proteomic Biomarkers Prediction of Calpain-2 &Caspase-3 Protease Fragmentation: Application to ?II-Spectrin Protein.
NRF-1, and AP-1 regulate the promoter of the human calpain small subunit 1 (CAPNS1) gene.
Overexpression of m-calpain in human colorectal adenocarcinomas.
Regulation of proteolytic cleavage of retinoid X receptor-? by GSK-3?
Strain-related differences in the pneumotoxic effects of chronically administered butylated hydroxytoluene on protein kinase C and calpain.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation.
Nervous System Diseases
The calpain family and human disease.
Neuralgia
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Calpain-2 Regulates TNF-? Expression Associated with Neuropathic Pain Following Motor Nerve Injury.
Neuroblastoma
Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system.
Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells.
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Neurodegenerative Diseases
Calcium-activated calpain-2 is a mediator of beta cell dysfunction and apoptosis in type 2 diabetes.
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Obesity
Calpains and their multiple roles in diabetes mellitus.
Osteoarthritis
G1-G2 aggrecan product that can be generated by M-calpain on truncation at Ala709-Ala710 is present abundantly in human articular cartilage.
Inflammatory cytokines induced down-regulation of m-calpain mRNA expression in fibroblastic synoviocytes from patients with osteoarthritis and rheumatoid arthritis.
Ovarian Neoplasms
Calpain system protein expression and activity in ovarian cancer.
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Expression of Syk and MAP4 proteins in ovarian cancer.
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Pancreatic Neoplasms
The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model.
Paralysis
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Parkinson Disease
Calpastatin immunoreactivity in the monkey and human brain of control subjects and patients with Parkinson's disease.
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Pneumonia
Calpeptin attenuates cigarette smoke-induced pulmonary inflammation via suppressing calpain/I?B? signaling in mice and BEAS-2B cells.
Prostatic Neoplasms
Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines.
Calpain-2 as a target for limiting prostate cancer invasion.
Calpain-2 triggers prostate cancer metastasis via enhancing CRMP4 promoter methylation through NF-?B/DNMT1 signaling pathway.
Cleavage of beta-catenin by calpain in prostate and mammary tumor cells.
Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression.
The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells.
Psoriasis
Autoantibodies directed against the protease inhibitor calpastatin in psoriasis.
Rabies
RVG-Mediated Calpain2 Gene Silencing in the Brain Impairs Learning and Memory.
Seizures
Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.
M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation.
Sepsis
Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism.
Severe Acute Respiratory Syndrome
Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain.
Small Cell Lung Carcinoma
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.
Spinal Cord Ischemia
Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits.
Starvation
A key role for calpains in retinal ganglion cell death.
Stomach Neoplasms
Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivo.
Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa.
Striatonigral Degeneration
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Stroke
The calpain family and human disease.
Supranuclear Palsy, Progressive
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Increased M-calpain expression in the mesencephalon of patients with Parkinson's disease but not in other neurodegenerative disorders involving the mesencephalon: a role in nerve cell death?
Tauopathies
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
P301L tauopathy: confocal immunofluorescence study of perinuclear aggregation of the mutated protein.
Urinary Incontinence
miR-93?mediated collagen expression in stress urinary incontinence via calpain-2.
The role of calpain-calpastatin system in the development of stress urinary incontinence.
Wolfram Syndrome
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome.