Disease on EC 3.4.22.52 - calpain-1

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Habitual
Role of mu-Calpain in Human Decidua for Recurrent Miscarriage.
Acute Kidney Injury
Perspective on rhabdomyolysis-induced acute kidney injury and new treatment options.
Adenocarcinoma
Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma.
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Adenocarcinoma of Lung
Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling.
mu-Calpain regulates caspase-dependent and apoptosis inducing factor-mediated caspase-independent apoptotic pathways in cisplatin-induced apoptosis.
Adenocarcinoma, Mucinous
Expression of Syk and MAP4 proteins in ovarian cancer.
Alzheimer Disease
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease.
C-terminal truncation of GSK-3? enhances its dephosphorylation by PP2A.
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.
Calpain activation in neurodegenerative diseases: confocal immunofluorescence study with antibodies specifically recognizing the active form of calpain 2.
Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain.
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.
Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's Disease.
Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies.
The calpain family and human disease.
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain.
Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.
Truncation and activation of GSK-3? by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
Amyotrophic Lateral Sclerosis
Role of calpain-1 in the early phase of experimental ALS.
Anaphylaxis
Chemonucleolysis with calpain I in rabbits.
Anemia, Sickle Cell
Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology.
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease.
Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.
Aneurysm
The role of extracellular and intracellular proteolytic systems in aneurysms of the ascending aorta.
Aortic Aneurysm
The role of extracellular and intracellular proteolytic systems in aneurysms of the ascending aorta.
Aortic Aneurysm, Abdominal
Calpain-2 Compensation Promotes Angiotensin II-Induced Ascending and Abdominal Aortic Aneurysms in Calpain-1 Deficient Mice.
Arsenic Poisoning
[Effects of arsenic poisoning on neuronal cell apoptosis and mRNA and protein expression of calpain 1, calpain 2, and cdk5/p25].
Arthritis, Rheumatoid
Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?
Ataxia
A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.
CAPN1 mutations are associated with a syndrome of combined spasticity and ataxia.
CAPN1 mutations broadening the hereditary spastic paraplegia/spinocerebellar ataxia phenotype.
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.
Postnatal calpain inhibition elicits cerebellar cell death and motor dysfunction.
Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review.
Ataxia Telangiectasia
The expression of genes related to adipocyte differentiation in pigs.
Atherosclerosis
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
Downregulations of CD36 and Calpain-1, Inflammation, and Atherosclerosis by Simvastatin in Apolipoprotein E Knockout Mice.
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Atrial Fibrillation
Calpain I inhibition prevents atrial structural remodeling in a canine model with atrial fibrillation.
[Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]
[Calpain-I, calpastatin, caspase-3 and apoptosis in the human left atrium in rheumatic atrial fibrillation]
[Effect of calpain 1 on structural remodeling and contractile dysfunction in atrial fibrillation: experiment with dogs]
[Influence of oxidative stress on atrial myocardium pathohistological and ultrastructural changes in atrial fibrillation: experiment with dogs]
Blindness
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.
Blister
Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.
Bone Resorption
A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.
Involvement of calpain in osteoclastic bone resorption.
Brain Injuries
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Brain Injuries, Traumatic
A calpain inhibitor attenuates cortical cytoskeletal protein loss after experimental traumatic brain injury in the rat.
Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury.
Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.
Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo.
Immunoblot analyses of the relative contributions of cysteine and aspartic proteases to neurofilament breakdown products following experimental brain injury in rats.
mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury.
pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat.
Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study.
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
Brain Ischemia
20(R)-Ginsenoside Rg3 protects SH-SY5Y cells against apoptosis induced by oxygen and glucose deprivation/reperfusion.
Brain mu-calpain autolysis during global cerebral ischemia.
Calpain inhibitor A-558693 in experimental focal cerebral ischemia in rats.
Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia.
Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.
Eukaryotic initiation factor 4E degradation during brain ischemia.
Exploration of the importance of the P2-P3-NHCO-moiety in a potent di- or tripeptide inhibitor of calpain I: insights into the development of nonpeptidic inhibitors of calpain I.
Ischemia-induced modifications of protein components of rat brain postsynaptic densities.
Neurovascular and neuronal protection by E64d after focal cerebral ischemia in rats.
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors.
RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia.
Synergetic Effects of Caspase 3 and mu-Calpain in XIAP-Breakdown upon Focal Cerebral Ischemia.
Breast Neoplasms
Calcium as a mediator of 1,25-dihydroxyvitamin D3-induced apoptosis.
Calcium signaling in cancer and vitamin D.
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis.
Calpain system protein expression in basal-like and triple-negative invasive breast cancer.
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study.
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain.
Effects of ARHI on cell cycle progression and apoptosis levels of breast cancer cells.
Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Genistein induces Ca2+ -mediated, calpain/caspase-12-dependent apoptosis in breast cancer cells.
Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer.
Low calpain-9 is associated with adverse disease-specific survival following endocrine therapy in breast cancer.
Mu-calpain activation in beta-lapachone-mediated apoptosis.
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Type V collagen-induced upregulation of capn2 (large subunit of m-calpain) gene expression and DNA fragmentation in 8701-BC breast cancer cells.
calpain-1 deficiency
Calpain-1 contributes to IgE-mediated mast cell activation.
Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
calpain-2 deficiency
Genetic Models of Calpain Deficiency and Ectopic Expression.
Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.
Carcinogenesis
ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Carcinoma
1,25-Dihydroxyvitamin D3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma.
A comparison of the intracellular distribution of mu-calpain, m-calpain, and calpastatin in proliferating human A431 cells.
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma.
Calpain system protein expression and activity in ovarian cancer.
Calpain-2 expression is associated with response to platinum based chemotherapy, progression-free and overall survival in ovarian cancer.
Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma.
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma.
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Carcinoma, Hepatocellular
Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network.
Growth of hepatocellular carcinoma in the regenerating liver.
Interference with Ca(2+)-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia.
Carcinoma, Renal Cell
1,25-Dihydroxyvitamin D3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma.
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Carcinoma, Squamous Cell
Calpain-calpastatin interactions in epidermoid carcinoma KB cells.
High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma.
Cardiomegaly
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Early dystrophin loss is coincident with the transition of compensated cardiac hypertrophy to heart failure.
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-?B activation in streptozotocin-induced diabetic rats.
[Role of valsartan on myocardial Calpain I, calcineurin and Ca/calmodulin-dependent protein kinase II? expression of renovascular hypertensive rats].
Cardiomyopathies
[Effect of valsartan and carnitine on cardiomyocyte Calpain-1 and Bcl-xl expressions of dogs with chronic alcohol intake-induced cardiomyopathy].
Cardiomyopathy, Alcoholic
Chronic alcohol intake-induced oxidative stress and apoptosis: role of CYP2E1 and calpain-1 in alcoholic cardiomyopathy.
Cataract
Calpains and their multiple roles in diabetes mellitus.
In vitro precipitation of rat lens crystallins by calpain I--a calpain requiring low amounts of calcium for activation.
Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains.
Cerebellar Ataxia
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family.
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Cholecystitis
Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma.
Cholesteatoma
Clinical and biochemical studies of bone destruction in cholesteatoma.
Coinfection
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system.
Cystic Fibrosis
Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis.
Genome-wide association study for poor sperm motility in Holstein-Friesian bulls.
Dehydration
Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease.
Dementia
Accumulation of ?-synuclein in dementia with Lewy bodies is associated with decline in the ?-synuclein-degrading enzymes kallikrein-6 and calpain-1.
Diabetes Mellitus
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.
Diabetes Mellitus, Type 2
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.
Diabetic Cardiomyopathies
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
Dyskinesias
The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson?s disease therapy.
Endometrial Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in endometrial cancer.
Endotoxemia
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Epilepsy
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Essential Hypertension
Normal erythrocyte calpain I activity on membrane proteins under near-physiological conditions in patients with essential hypertension.
Fanconi Anemia
Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair.
Frontotemporal Dementia
FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.
Glaucoma
Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics.
Glioblastoma
A positive feedback loop involving nuclear factor IB and calpain 1 suppresses glioblastoma cell migration.
Glucose Intolerance
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress.
Heart Arrest
Brain mu-calpain autolysis during global cerebral ischemia.
Calpain mediates eukaryotic initiation factor 4G degradation during global brain ischemia.
Heart Diseases
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Heart Failure
Calpain protects the heart from hemodynamic stress.
Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion.
Herpes Simplex
Calcium-signal facilitates herpes simplex virus type 1 nuclear transport through slingshot 1 and calpain-1 activation.
ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+.
Huntington Disease
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.
Hyperalgesia
Calpain-2 contributes to neuropathic pain following motor nerve injury via up-regulating interleukin-6 in DRG neurons.
Hyperglycemia
Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain.
Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes.
The Abnormal Architecture of Healed Diabetic Ulcers Is the Result of FAK Degradation by Calpain 1.
Hypertension
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
Normal erythrocyte calpain I activity on membrane proteins under near-physiological conditions in patients with essential hypertension.
Hypertension, Pulmonary
Identification of calpastatin and micro-calpain and studies of their association in pulmonary smooth muscle mitochondria.
Ichthyosis, Lamellar
The calcium-activated neutral protease calpain I is present in normal foetal skin and is decreased in neonatal harlequin ichthyosis.
Infarction, Middle Cerebral Artery
Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1.
Infections
Biologically active monomeric and heterodimeric recombinant human calpain I produced using the baculovirus expression system.
Calpain 1 and 2 are required for RNA replication of echovirus 1.
Degradation of p21cip1 in cells productively infected with human cytomegalovirus.
Targeting calpains: A novel immunomodulatory approach for microbial infections.
TGF-? Pathway Inhibition Protectsthe Diaphragm From Sepsis-Induced Wasting and Weakness in Rat.
Inflammatory Breast Neoplasms
The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy.
Kidney Calculi
Characterizations of HSP90-Interacting Complex in Renal Cells Using Tandem Affinity Purification and Its Potential Role in Kidney Stone Formation.
Leishmaniasis
Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania.
Leukemia
Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia.
Neutrophil chemotactic N-acetyl peptides from the calpain small subunit are also chemotactic for immunocytes.
Leukemia, Myeloid, Acute
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes.
[Beta-carotene regulates the expression of proapoptotic BAX and CAPN2 in HL-60, U-937 and TF-1 - human acute myeloid leukemia cell lines; microarray, RQ-PCR and Western Blot analysis].
Leukemia, Neutrophilic, Chronic
Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia.
Lung Injury
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.
Lung Neoplasms
Calpain 2 knockdown promotes cell apoptosis and restores gefitinib sensitivity through epidermal growth factor receptor/protein kinase B/survivin signaling.
Lymphoma
Induction of apoptosis in E?-myc lymphoma cells in vitro and in vivo through calpain inhibition.
Malaria
Cerebral calpain in fatal falciparum malaria.
Malaria, Cerebral
Proteolytic breakdown of cytoskeleton induces neurodegeneration during pathology of murine cerebral malaria.
Melanoma
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Correction: CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Wnt5A Activates the Calpain-Mediated Cleavage of Filamin A.
Meningioma
Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis of tumorigenesis.
Molecular alterations in the neurofibromatosis type 2 gene and its protein rarely occurring in meningothelial meningiomas.
Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas.
Multiple Endocrine Neoplasia
A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
Multiple Endocrine Neoplasia Type 1
A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
Multiple System Atrophy
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of ?-synuclein in multiple system atrophy.
Muscle Spasticity
Calpain-calpastatin system of canine basilar artery in vasospasm.
CAPN1 mutations broadening the hereditary spastic paraplegia/spinocerebellar ataxia phenotype.
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Generation of the catalytic fragment of protein kinase C alpha in spastic canine basilar artery.
Muscular Atrophy
Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels.
Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats.
Muscular Diseases
Cellular and molecular signatures of alcohol-induced myopathy in women.
Myalgia
A post-transcriptional mechanism regulates calpastatin expression in bovine skeletal muscle.
Effects of duration of vitamin C supplementation during the finishing period on postmortem protein degradation, tenderness, and meat color of the longissimus muscle of calf-fed steers consuming a 0.31 or 0.59% sulfur diet.
[Study on correlation between single nucleotide polymorphism of CAPN1 gene and muscle tenderness and carcass traits in chicken]
Myocardial Infarction
Calcium channel blockade limits transcriptional, translational and functional up-regulation of the cardiac calpain system after myocardial infarction.
Myocardial Ischemia
Selective Deletion of the NH(2)-Terminal Variable Region of Cardiac Troponin T in Ischemia Reperfusion by Myofibril-Associated mu-Calpain Cleavage.
Myocardial Stunning
Role of troponin I proteolysis in the pathogenesis of stunned myocardium.
Neoplasm Metastasis
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients.
miR-203 inhibits augmented proliferation and metastasis of hepatocellular carcinoma residual in the promoted regenerating liver.
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Proteomics study of serum exosomes from papillary thyroid cancer patients.
STK33 potentiates the malignancy of hypopharyngeal squamous carcinoma: Possible relation to calcium.
Neoplasms
A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13.
ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis.
Association of mitochondrial calpain activation with increased expression and autolysis of calpain small subunit in an early stage of apoptosis.
Calcium signaling in cancer and vitamin D.
Calpain 1 in bronchoalveolar lavage fluid is associated with poor prognosis in lepidic predominant pulmonary adenocarcinoma.
Calpain regulates sensitivity to trastuzumab and survival in HER2-positive breast cancer.
Calpain restrains the stem cells compartment in breast cancer.
Calpain system protein expression and activity in ovarian cancer.
Calpain system protein expression in basal-like and triple-negative invasive breast cancer.
Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index.
Calpain-1 expression is associated with relapse-free survival in breast cancer patients treated with trastuzumab following adjuvant chemotherapy.
Calpains and cytokines in fibrillating human atria.
Calpains, mitochondria, and apoptosis.
CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Capn4 regulates migration and invasion of ovarian carcinoma cells via targeting osteopontin-mediated PI3K/AKT signaling pathway.
Chronic administration of UK-114, a multifunctional emerging protein, modulates the Th1/Th2 cytokine pattern and experimental autoimmune diseases.
Clinical correlation of calpain-1 and glypican-3 expression with gallbladder carcinoma.
Comparative Proteome Profiling and Mutant Protein Identification in Metastatic Prostate Cancer Cells by Quantitative Mass Spectrometry-based Proteogenomics.
Correction: CAPN1 is a novel binding partner and regulator of the tumor suppressor NF1 in melanoma.
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding.
Expression of calpain I messenger RNA in human renal cell carcinoma: correlation with lymph node metastasis and histological type.
Expression of Syk and MAP4 proteins in ovarian cancer.
Expression of the calpain system is associated with poor clinical outcome in gastro-oesophageal adenocarcinomas.
Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.
Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib.
Genetic mapping studies of 40 loci and 23 cosmids in chromosome 11p13-11q13, and exclusion of mu-calpain as the multiple endocrine neoplasia type 1 gene.
High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients.
High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma.
Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP).
I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway.
Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer.
LRH1 as a driving factor in pancreatic cancer growth.
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-?B activation in streptozotocin-induced diabetic rats.
Microarray and pattern miner analysis of AXL and VIM gene networks in MDA?MB?231 cells.
mu-Calpain is involved in the regulation of TNF-alpha-induced matrix metalloproteinase-3 release in a rheumatoid synovial cell line.
NF-Kappa-B downregulation strategies in head and neck cancer treatment.
Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma.
Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer.
Proteomics study of serum exosomes from papillary thyroid cancer patients.
Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-?B (NF-?B).
Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.
[The changes of gene expression in multiple myeloma treated with thalidomide]
Neoplasms, Squamous Cell
NF-Kappa-B downregulation strategies in head and neck cancer treatment.
Nervous System Diseases
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
The calpain family and human disease.
Neurilemmoma
Tight association of loss of merlin expression with loss of heterozygosity at chromosome 22q in sporadic meningiomas.
Neuroblastoma
Calpains and calpastatin in SH-SY5Y neuroblastoma cells during retinoic acid-induced differentiation and neurite outgrowth: comparison with the human brain calpain system.
Mitochondrial localization of mu-calpain.
Mitochondrial mu-calpain is not involved in the processing of apoptosis-inducing factor.
N terminus of calpain 1 is a mitochondrial targeting sequence.
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells - implications for neuroprotection against Ca-mediated excitotoxicity.
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex.
Neurodegenerative Diseases
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors.
Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress.
Neurologic Manifestations
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Obesity
Calpains and their multiple roles in diabetes mellitus.
Osteosarcoma
Calpain mobilizes Atg9/Bif-1 vesicles from Golgi stacks upon autophagy induction by thapsigargin.
DNA damage response links calpain to cellular senescence.
Ototoxicity
Calpain mediated cisplatin-induced ototoxicity in mice.
Ovarian Neoplasms
Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.
Pancreatic Neoplasms
High calpain-1 expression predicts a poor clinical outcome and contributes to tumor progression in pancreatic cancer patients.
The calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model.
Pancreatitis
Calpain I inhibitor ameliorates the indices of disease severity in a murine model of cerulein-induced acute pancreatitis.
Paraparesis, Spastic
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
Paraplegia
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
CAPN1 Variants as Cause of Hereditary Spastic Paraplegia Type 76.
Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review.
Parkinson Disease
Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease.
Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology.
Peripheral Nervous System Diseases
Discrete proteolysis of neuronal calcium sensor-1 (NCS-1) by mu-calpain disrupts calcium binding.
Pleural Effusion, Malignant
Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion.
Prostatic Neoplasms
Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway.
Protein Deficiency
Klotho protein deficiency leads to overactivation of mu-calpain.
Psoriasis
Human S100A7 Induces Mature Interleukin1? Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis.
Pulmonary Arterial Hypertension
Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Reperfusion Injury
Neuregulin-1? Plays a Neuroprotective Role by Inhibiting the Cdk5 Signaling Pathway after Cerebral Ischemia-Reperfusion Injury in Rats.
Neuroprotective effect of 20(R)-ginsenoside Rg(3) against transient focal cerebral ischemia in rats.
Rheumatic Heart Disease
[Calpain-I, calpastatin, caspase-3 and apoptosis in the human left atrium in rheumatic atrial fibrillation]
Seizures
Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.
[Protective effects of levetiracetam and simvastatin on pilocarpine-induced epilepsy in rat models].
Sepsis
Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition.
Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats.
Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism.
Spastic Paraplegia, Hereditary
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family.
A Novel Homozygous CAPN1 Pathogenic Variant in a Chinese Patient with Pure Hereditary Spastic Paraplegia.
CAPN1 mutations: Expanding the CAPN1-related phenotype: From hereditary spastic paraparesis to spastic ataxia.
CAPN1 Variants as Cause of Hereditary Spastic Paraplegia Type 76.
Clinical aspects of hereditary spastic paraplegia 76 and novel CAPN1 mutations.
Generation of an integration-free induced pluripotent stem cell line, FJMUi001-A, from a hereditary spastic paraplegia patient carrying compound heterozygous p.P498L and p.R618W mutations in CAPN1 (SPG76).
Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia.
Two novel homozygous mutations of CAPN1 in Chinese patients with hereditary spastic paraplegia and literatures review.
Spermatic Cord Torsion
Involvement of calpain for apoptosis in dysfunction of the unaffected testis in rats with experimental testicular torsion.
Spinal Cord Injuries
Calpain 1 Knockdown Improves Tissue Sparing and Functional Outcomes after Spinal Cord Injury in Rats.
Calpain inhibitor inhibits p35-p25-Cdk5 activation, decreases tau hyperphosphorylation, and improves neurological function after spinal cord hemisection in rats.
Pretreatment with calpain inhibitor CEP-4143 inhibits calpain I activation and cytoskeletal degradation, improves neurological function, and enhances axonal survival after traumatic spinal cord injury.
Rapid calpain I activation and cytoskeletal protein degradation following traumatic spinal cord injury: attenuation with riluzole pretreatment.
Spinal Cord Ischemia
Degradation of spectrin via calpains in the ventral horn after transient spinal cord ischemia in rabbits.
Spinocerebellar Ataxias
A Novel CAPN1 Mutation Causes a Pure Hereditary Spastic Paraplegia in an Italian Family.
Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans.
Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed.
Starvation
A key role for calpains in retinal ganglion cell death.
Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1.
Calpain small-1 modulates Akt/FoxO3A signaling and apoptosis through PP2A.
Identification and molecular characterization of the rainbow trout calpains (Capn1 and Capn2): their expression in muscle wasting during starvation.
New localization and function of calpain-2 in nucleoli of colorectal cancer cells in ribosomal biogenesis: effect of KRAS status.
Status Epilepticus
Calpain I Activity and Its Relationship with Hippocampal Neuronal Death in Pilocarpine-Induced Status Epilepticus Rat Model.
Mu-calpain mediates hippocampal neuron death in rats after lithium-pilocarpine-induced status epilepticus.
Participation of mu-calpain in status epilepticus-induced hippocampal injury.
Stomach Neoplasms
Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa.
Dehydroabietic Acid Derivative QC4 Induces Gastric Cancer Cell Death via Oncosis and Apoptosis.
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1.
The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
Stroke
Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors.
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1.
Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I.
The calpain family and human disease.
Synucleinopathies
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation.
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro.
Tauopathies
?-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
Triple Negative Breast Neoplasms
Calpain-1 Expression in Triple-Negative Breast Cancer: A Potential Prognostic Factor Independent of the Proliferative/Apoptotic Index.
Cisplatin Induces Apoptosis Through the Endoplasmic Reticulum-mediated, Calpain 1 Pathway in Triple-negative Breast Cancer Cells.
Tuberculosis, Pleural
Calpain and spectrin breakdown products as potential biomarkers in tuberculous pleural effusion.
Urinary Incontinence
The role of calpain-calpastatin system in the development of stress urinary incontinence.
Vascular Calcification
Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL.
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis.
Vascular Diseases
Redox Regulation of Calpains: Consequences on Vascular Function.
Ventilator-Induced Lung Injury
In Vivo Calpain Knockdown Using Delivery of siRNA.