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Disease on EC 3.4.22.49 - separase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Blast Crisis
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Breast Neoplasms
A prognostic model based on cell-cycle control predicts outcome of breast cancer patients.
Biology and insights into the role of cohesin protease separase in human malignancies.
EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor-Positive Breast Cancer.
ESPL1 is a candidate oncogene of luminal B breast cancers.
Genetically engineered ER? positive breast cancer mouse models.
Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive, Early Breast Cancer.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Separase is a marker for prognosis and mitotic activity in breast cancer.
Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study.
Carcinogenesis
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
Biology and insights into the role of cohesin protease separase in human malignancies.
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Separase prevents genomic instability by controlling replication fork speed.
Carcinoma
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Communicable Diseases
CMS Measure Stewards' Assessment of the Infectious Diseases Society of America's Position Paper on SEP-1.
Recommended Revisions to the National SEP-1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper.
Endometrial Neoplasms
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Glioblastoma
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Glioma
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma.
Hepatitis B
Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Herpes Zoster
Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
Infertility
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.
Leukemia
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Leukemia, Myeloid, Acute
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Liver Neoplasms
Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Lung Neoplasms
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Lymphoma, B-Cell
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Myelodysplastic Syndromes
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Myocardial Infarction
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
Neoplasm Metastasis
A Gleason score-related outcome model for human prostate cancer: a comprehensive study based on weighted gene co-expression network analysis.
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Neoplasms
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement.
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Biology and insights into the role of cohesin protease separase in human malignancies.
Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion.
Chromatin compaction by condensin I, intra-kinetochore stretch and tension, and anaphase onset, in collective spindle assembly checkpoint interaction.
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Data set on Separase Inhibitor-Sepin-1 toxicity on organ weights, hematology and clinical parameters in Sprague-Dawley rats.
Development and validation of a fluorogenic assay to measure separase enzyme activity.
EarlyR signature predicts response to neoadjuvant chemotherapy in breast cancer.
ESPL1 is a candidate oncogene of luminal B breast cancers.
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
Identification of Bioactive Small Molecule Inhibitors of Separase.
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Molecular mechanism for the regulation of yeast separase by securin.
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.
Prolonged mitosis causes separase deregulation and chromosome nondisjunction.
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Separase is a marker for prognosis and mitotic activity in breast cancer.
Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene.
Stability and pharmacokinetics of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Structure and Function of the Separase-Securin Complex.
Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase.
The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.
The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes.
The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib.
Toxicity study of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
[Separase, a key-player of mitosis: A new target for cancer therapy?]
Osteosarcoma
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Pituitary Neoplasms
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.
Prostatic Neoplasms
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Sepsis
Accountability for Sepsis Treatment: The SEP-1 Core Measure.
Adherence to the SEP-1 Sepsis Bundle in Hospital-Onset v. Community-Onset Sepsis: a Multicenter Retrospective Cohort Study.
Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis.
Association of Hospital Characteristics With Early SEP-1 Performance.
Comparison of an ED triage sepsis screening tool and qSOFA in identifying CMS SEP-1 patients.
Comparison of Automated Sepsis Identification Methods and Electronic Health Record-based Sepsis Phenotyping: Improving Case Identification Accuracy by Accounting for Confounding Comorbid Conditions.
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Driving blind: instituting SEP-1 without high quality outcomes data.
Evaluation of hospital nurse-to-patient staffing ratios and sepsis bundles on patient outcomes.
Evidence Underpinning the U.S. Government-Mandated Hemodynamic Interventions for Sepsis: A Systematic Review.
Failure to Clear Intermediate Lactate Levels in Ward Patients With Admission Blood Cultures Did Not Increase the Risk of Intensive Care Unit Transfer or In-Hospital Mortality: A Retrospective Cohort Study.
Hospital Perceptions of Medicare's Sepsis Quality Reporting Initiative.
Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department.
Impact of the Centers for Medicare and Medicaid Services Sepsis Core Measure on Antibiotic Use.
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.
Influencing outcomes with automated time zero for sepsis through statistical validation and process improvement.
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
Nurse Influence in Meeting Compliance With the Centers for Medicare and Medicaid Services Quality Measure: Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1).
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
Recommended Revisions to the National SEP-1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper.
Seeking a balanced approach to implementing sepsis guidelines.
SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care…But Now Is the Time to Improve SEP-1.
SEP-1: A Sepsis Measure in Need of Resuscitation?
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
Sepsis quality in safety-net hospitals: An analysis of Medicare's SEP-1 performance measure.
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock.
Treatment Patterns and Clinical Outcomes After the Introduction of the Medicare Sepsis Performance Measure (SEP-1).
Utilization of a multidisciplinary emergency department sepsis huddle to reduce time to antibiotics and improve SEP-1 compliance.
Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure.
Shock, Septic
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department.
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
SEP-1 Septic Shock Bundle Guidelines Not Applicable to Inpatients-Reply.
SEP-1 Septic Shock Bundle Guidelines Not Applicable to Inpatients.
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock.
Skin Neoplasms
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Stroke
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
Thoracic Diseases
Regarding Journal of Thoracic Disease Vol 12, Supplement 1 (February 2020) (Sepsis: Science and Fiction)-Driving blind: instituting SEP-1 without high quality outcomes data.