Disease on EC 3.4.22.49 - separase

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DISEASE
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Blast Crisis
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Breast Neoplasms
Biology and insights into the role of cohesin protease separase in human malignancies.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Separase is a marker for prognosis and mitotic activity in breast cancer.
Carcinogenesis
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
Biology and insights into the role of cohesin protease separase in human malignancies.
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Separase prevents genomic instability by controlling replication fork speed.
Carcinoma
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Glioblastoma
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Herpes Zoster
Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
Infertility
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.
Leukemia
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Leukemia, Myeloid, Acute
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Lung Neoplasms
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Lymphoma, B-Cell
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Myelodysplastic Syndromes
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Myocardial Infarction
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
Neoplasm Metastasis
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Neoplasms
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Biology and insights into the role of cohesin protease separase in human malignancies.
Chromatin compaction by condensin I, intra-kinetochore stretch and tension, and anaphase onset, in collective spindle assembly checkpoint interaction.
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Molecular mechanism for the regulation of yeast separase by securin.
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Overexpression of Separase induces aneuploidy and mammary tumorigenesis.
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Separase is a marker for prognosis and mitotic activity in breast cancer.
Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene.
Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase.
The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.
The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib.
Osteosarcoma
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Pituitary Neoplasms
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.
Prostatic Neoplasms
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Sepsis
Accountability for Sepsis Treatment: The SEP-1 Core Measure.
Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).
Association of Hospital Characteristics With Early SEP-1 Performance.
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Evidence Underpinning the U.S. Government-Mandated Hemodynamic Interventions for Sepsis: A Systematic Review.
Hospital Perceptions of Medicare's Sepsis Quality Reporting Initiative.
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
National Performance on the Medicare SEP-1 Sepsis Quality Measure.
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
Nurse Influence in Meeting Compliance With the Centers for Medicare and Medicaid Services Quality Measure: Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1).
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
SEP-1: A Sepsis Measure in Need of Resuscitation?
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
Sepsis quality in safety-net hospitals: An analysis of Medicare's SEP-1 performance measure.
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock.
Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure.
Shock, Septic
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock.
Skin Neoplasms
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Stroke
National Performance on the Medicare SEP-1 Sepsis Quality Measure.