Disease on EC 3.4.22.49 - separase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Blast Crisis
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.
Blast Crisis
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Breast Neoplasms
A prognostic model based on cell-cycle control predicts outcome of breast cancer patients.
Breast Neoplasms
Biology and insights into the role of cohesin protease separase in human malignancies.
Breast Neoplasms
EarlyR: A Robust Gene Expression Signature for Predicting Outcomes of Estrogen Receptor-Positive Breast Cancer.
Breast Neoplasms
Independent Validation of EarlyR Gene Signature in BIG 1-98: A Randomized, Double-Blind, Phase III Trial Comparing Letrozole and Tamoxifen as Adjuvant Endocrine Therapy for Postmenopausal Women With Hormone Receptor-Positive, Early Breast Cancer.
Breast Neoplasms
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Breast Neoplasms
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Breast Neoplasms
Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study.
Carcinogenesis
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
Carcinogenesis
Biology and insights into the role of cohesin protease separase in human malignancies.
Carcinogenesis
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Carcinogenesis
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
Carcinogenesis
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Carcinogenesis
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Carcinogenesis
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Carcinogenesis
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Carcinogenesis
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Carcinogenesis
Separase prevents genomic instability by controlling replication fork speed.
Carcinoma
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Communicable Diseases
CMS Measure Stewards' Assessment of the Infectious Diseases Society of America's Position Paper on SEP-1.
Communicable Diseases
Recommended Revisions to the National SEP-1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper.
Endometrial Neoplasms
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer.
Glioblastoma
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Glioma
ESPL1 Is a Novel Prognostic Biomarker Associated With the Malignant Features of Glioma.
Hepatitis B
Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Infertility
Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation.
Leukemia
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Leukemia
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Leukemia
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients.
Leukemia, Myeloid, Acute
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Liver Neoplasms
Serum ESPL1 Can Be Used as a Biomarker for Patients With Hepatitis B Virus-Related Liver Cancer: A Chinese Case-Control Study.
Lung Neoplasms
Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.
Lymphoma, B-Cell
Separase Loss of Function Cooperates with the Loss of p53 in the Initiation and Progression of T- and B-Cell Lymphoma, Leukemia and Aneuploidy in Mice.
Myelodysplastic Syndromes
Increased separase activity and occurrence of centrosome aberrations concur with transformation of MDS.
Neoplasm Metastasis
A Gleason score-related outcome model for human prostate cancer: a comprehensive study based on weighted gene co-expression network analysis.
Neoplasm Metastasis
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Neoplasm Metastasis
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Neoplasm Metastasis
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Neoplasms
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.
Neoplasms
A NUP98-positive acute myeloid leukemia with a t(11;12)(p15;q13) without HOXC cluster gene involvement.
Neoplasms
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Neoplasms
Biology and insights into the role of cohesin protease separase in human malignancies.
Neoplasms
Centrosome reduction in newly-generated tetraploid cancer cells obtained by separase depletion.
Neoplasms
Chromatin compaction by condensin I, intra-kinetochore stretch and tension, and anaphase onset, in collective spindle assembly checkpoint interaction.
Neoplasms
Clonal Evolution and Blast Crisis Correlate with Enhanced Proteolytic Activity of Separase in BCR-ABL b3a2 Fusion Type CML under Imatinib Therapy.
Neoplasms
Data set on Separase Inhibitor-Sepin-1 toxicity on organ weights, hematology and clinical parameters in Sprague-Dawley rats.
Neoplasms
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Neoplasms
Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy.
Neoplasms
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Neoplasms
Measurement of Separase Proteolytic Activity in Single Living Cells by a Fluorogenic Flow Cytometry Assay.
Neoplasms
MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas.
Neoplasms
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Neoplasms
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Neoplasms
Separase Inhibitor Sepin-1 Inhibits Foxm1 Expression and Breast Cancer Cell Growth.
Neoplasms
Stability and pharmacokinetics of separase inhibitor-Sepin-1 in Sprague-Dawley rats.
Neoplasms
The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.
Neoplasms
The Proteolytic Activity of Separase in BCR-ABL-Positive Cells Is Increased by Imatinib.
Osteosarcoma
Development and validation of a fluorogenic assay to measure separase enzyme activity.
Osteosarcoma
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Pituitary Neoplasms
A single mutation in Securin induces chromosomal instability and enhances cell invasion.
Pituitary Neoplasms
Pttg1/securin is required for the branching morphogenesis of the mammary gland and suppresses mammary tumorigenesis.
Prostatic Neoplasms
Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.
Sepsis
Adherence to the SEP-1 Sepsis Bundle in Hospital-Onset v. Community-Onset Sepsis: a Multicenter Retrospective Cohort Study.
Sepsis
Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).
Sepsis
Association of a Care Bundle for Early Sepsis Management With Mortality Among Patients With Hospital-Onset or Community-Onset Sepsis.
Sepsis
Comparison of an ED triage sepsis screening tool and qSOFA in identifying CMS SEP-1 patients.
Sepsis
Comparison of Automated Sepsis Identification Methods and Electronic Health Record-based Sepsis Phenotyping: Improving Case Identification Accuracy by Accounting for Confounding Comorbid Conditions.
Sepsis
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Sepsis
Evaluation of hospital nurse-to-patient staffing ratios and sepsis bundles on patient outcomes.
Sepsis
Evidence Underpinning the U.S. Government-Mandated Hemodynamic Interventions for Sepsis: A Systematic Review.
Sepsis
Failure to Clear Intermediate Lactate Levels in Ward Patients With Admission Blood Cultures Did Not Increase the Risk of Intensive Care Unit Transfer or In-Hospital Mortality: A Retrospective Cohort Study.
Sepsis
Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department.
Sepsis
Impact of the Centers for Medicare and Medicaid Services Sepsis Core Measure on Antibiotic Use.
Sepsis
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
Sepsis
Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.
Sepsis
Influencing outcomes with automated time zero for sepsis through statistical validation and process improvement.
Sepsis
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
Sepsis
Nurse Influence in Meeting Compliance With the Centers for Medicare and Medicaid Services Quality Measure: Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1).
Sepsis
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
Sepsis
Recommended Revisions to the National SEP-1 Sepsis Quality Measure: A commentary by the Society of Infectious Diseases Pharmacists on the Infectious Diseases Society of America Position Paper.
Sepsis
SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care
But Now Is the Time to Improve SEP-1.
Sepsis
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
Sepsis
Sepsis quality in safety-net hospitals: An analysis of Medicare's SEP-1 performance measure.
Sepsis
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock.
Sepsis
Treatment Patterns and Clinical Outcomes After the Introduction of the Medicare Sepsis Performance Measure (SEP-1).
Sepsis
Utilization of a multidisciplinary emergency department sepsis huddle to reduce time to antibiotics and improve SEP-1 compliance.
Sepsis
Variability in determining sepsis time zero and bundle compliance rates for the centers for medicare and medicaid services SEP-1 measure.
Shock, Septic
Compliance With the National SEP-1 Quality Measure and Association With Sepsis Outcomes: A Multicenter Retrospective Cohort Study.
Shock, Septic
Impact of SEP-1 on broad-spectrum combination antibiotic therapy in the emergency department.
Shock, Septic
Implementation of an adult code sepsis protocol and its impact on SEP-1 core measure perfect score attainment in the ED.
Shock, Septic
Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.
Shock, Septic
New Mandated Centers for Medicare and Medicaid Services Requirements for Sepsis Reporting: Caution from the Field.
Shock, Septic
Preliminary Performance on the New CMS Sepsis-1 National Quality Measure: Early Insights From the Emergency Quality Network (E-QUAL).
Shock, Septic
Sepsis National Hospital Inpatient Quality Measure (SEP-1): Multistakeholder Work Group Recommendations for Appropriate Antibiotics for the Treatment of Sepsis.
Shock, Septic
The Past, Present, and Future of the Centers for Medicare and Medicaid Services Quality Measure SEP-1: The Early Management Bundle for Severe Sepsis/Septic Shock.
Skin Neoplasms
Local activation of mammalian separase in interphase promotes double-strand break repair and prevents oncogenic transformation.
Thoracic Diseases
Regarding Journal of Thoracic Disease Vol 12, Supplement 1 (February 2020) (Sepsis: Science and Fiction)-Driving blind: instituting SEP-1 without high quality outcomes data.
html completed