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Disease on EC 3.4.22.46 - L-peptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Arteritis
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Cardiomyopathies
Soluble Coxsackievirus B3 3C Protease Inhibitor Prevents Cardiomyopathy in an Experimental Chronic Myocarditis Murine Model.
Clonorchiasis
Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen.
Common Cold
A simple solid phase, peptide-based fluorescent assay for the efficient and universal screening of HRV 3C protease inhibitors.
Lack of Respiratory and Contact Sensitizing Potential of the Intranasal Antiviral Drug Candidate Rupintrivir (AG7088): A Weight-of-the-Evidence Evaluation.
Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone).
Dengue
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Encephalitis, Tick-Borne
Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease.
Foot-and-Mouth Disease
3Cpro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation.
A continuous assay for foot-and-mouth disease virus 3C protease activity.
A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase.
Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus.
Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells.
Assembly of foot-and-mouth disease virus empty capsids synthesized by a vaccinia virus expression system.
Characterization of the foot-and-mouth disease virus 3C protease expressed in Escherichia coli.
Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site.
Cleavages at the three junctions within the foot-and-mouth disease virus capsid precursor (P1-2A) by the 3C protease are mutually independent.
Construction and immunogenicity of a recombinant fowlpox virus containing the capsid and 3C protease coding regions of foot-and-mouth disease virus.
Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity.
Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1alpha.
Crystal structure of the 3C protease from Southern African Territories type 2 foot-and-mouth disease virus.
Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy.
Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease.
Determinants of the VP1/2A junction cleavage by the 3C protease in foot-and-mouth disease virus-infected cells.
Development of replication-defective adenovirus serotype 5 containing the capsid and 3C protease coding regions of foot-and-mouth disease virus as a vaccine candidate.
Effect of foot-and-mouth disease virus 3C protease B2 ?-strand proline mutagenesis on expression and processing of the P1 polypeptide using a plasmid expression vector.
Effect of foot-and-mouth disease virus capsid precursor protein and 3C protease expression on bovine herpesvirus 1 replication.
Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity.
Evaluation of Gaussia luciferase and foot-and-mouth disease virus 2A translational interrupter chimeras as polycistronic reporters for transgene expression.
Expression in Escherichia coli and purification of biologically active L proteinase of foot-and-mouth disease virus.
Expression, processing, and assembly of foot-and-mouth disease virus capsid structures in heterologous systems: induction of a neutralizing antibody response in guinea pigs.
Foot and mouth disease leader protease (Lbpro): Investigation of prime side specificity allows the synthesis of a potent inhibitor.
Foot-and-Mouth Disease Virus 3C Protease Cleaves NEMO To Impair Innate Immune Signaling.
Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells.
Foot-and-Mouth Disease Virus 3C Protease Induces Fragmentation of the Golgi Compartment and Blocks Intra-Golgi Transport.
Foot-and-mouth disease virus 3C protease mutant L127P: Implications for FMD vaccine development.
Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target.
Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin.
Foot-and-Mouth Disease Virus Leader Protease Cleaves G3BP1 and G3BP2 and Inhibits Stress Granule Formation.
Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro.
Generation and genetic stability of tick-borne encephalitis virus mutants dependent on processing by the foot-and-mouth disease virus 3C protease.
Genetic analysis of foot-and-mouth disease virus serotype A of Indian origin and detection of positive selection and recombination in leader protease-and capsid-coding regions.
hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.
Hydrolytic properties and substrate specificity of the foot-and-mouth disease leader protease.
Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus.
Immunogenicity of the capsid precursor and a nine-amino-acid site-directed mutant of the 3C protease of foot-and-mouth disease virus coexpressed by a recombinant goatpox virus.
Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus.
Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate.
Interaction between FMDV L(pro) and transcription factor ADNP is required for optimal viral replication.
Investigating the Substrate Specificity and Oligomerisation of the Leader Protease of Foot and Mouth Disease Virus using NMR.
L protease from foot and mouth disease virus confers eIF2-independent translation for mRNAs bearing picornavirus IRES.
Low levels of foot-and-mouth disease virus 3Cpro expression are required to achieve optimal capsid protein expression and processing in mammalian cells.
MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response.
NS2B/3 proteolysis at the C-prM junction of the tick-borne encephalitis virus polyprotein is highly membrane dependent.
Phylogenetic analysis of 3C protease (3C(pro)) coding region of Foot-and-mouth disease virus type A.
Production of foot-and-mouth disease virus capsid proteins by the TEV protease.
Protection of guinea pigs and swine by a recombinant adenovirus expressing O serotype of foot-and-mouth disease virus whole capsid and 3C protease.
Sequence adaptations affecting cleavage of the VP1/2A junction by the 3C protease in foot-and-mouth disease virus infected cells.
Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site.
Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs?
Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes.
Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis.
Structure of the foot-and-mouth disease virus leader protease: a papain-like fold adapted for self-processing and eIF4G recognition.
Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection.
The effects of the synonymous codon usage and tRNA abundance on protein folding of the 3C protease of foot-and-mouth disease virus.
The internal ribosome entry site of the Dengue virus mRNA is active when cap-dependent translation initiation is inhibited.
Uncleaved 2A-peptide of foot-and-mouth disease virus can display foreign epitope-tag at the virion surface.
[Cloning and expression of 3C protease gene from foot-and-mouth disease virus in insect cell]
Fowlpox
Construction and immunogenicity of a recombinant fowlpox virus containing the capsid and 3C protease coding regions of foot-and-mouth disease virus.
Glioblastoma
The 3C protease activity of enterovirus 71 induces human neural cell apoptosis.
Hand, Foot and Mouth Disease
Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: A molecular dynamics study.
Hepatitis
Evaluation of the susceptibility of the 3C proteases of hepatitis A virus and poliovirus to degradation by the ubiquitin-mediated proteolytic system.
Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses.
Hepatitis A
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Assessing activity of Hepatitis A virus 3C protease using a cyclized luciferase-based biosensor.
Cleavage of poly(A)-binding protein by duck hepatitis A virus 3C protease.
Complete 1H, 13C and 15N backbone assignments for the hepatitis A virus 3C protease.
Cytotoxic effect of co-expression of human hepatitis A virus 3C protease and bifunctional suicide protein FCU1 genes in a bicistronic vector.
Degradation of the encephalomyocarditis virus and hepatitis A virus 3C proteases by the ubiquitin/26S proteasome system in vivo.
Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site.
Embryotoxic activity of 3C protease of human hepatitis A virus in developing Danio rerio embryos.
Evaluation of the susceptibility of the 3C proteases of hepatitis A virus and poliovirus to degradation by the ubiquitin-mediated proteolytic system.
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Functional binding of hexanucleotides to 3C protease of hepatitis A virus.
Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon.
Identification and site-directed mutagenesis of the primary (2A/2B) cleavage site of the hepatitis A virus polyprotein: functional impact on the infectivity of HAV RNA transcripts.
Identification of active-site amino acid residues in the Chiba virus 3C-like protease.
Identification of active-site residues in protease 3C of hepatitis A virus by site-directed mutagenesis.
In Vitro Assay for the Evaluation of Cytotoxic Effects Provided by a Combination of Suicide and Killer Genes in a Bicistronic Vector.
In vitro RNA binding of the hepatitis A virus proteinase 3C (HAV 3Cpro) to secondary structure elements within the 5' terminus of the HAV genome.
Individual Expression of Hepatitis A Virus 3C Protease Induces Ferroptosis in Human Cells In Vitro.
Kinetic analysis of the conjugation of ubiquitin to picornavirus 3C proteases catalyzed by the mammalian ubiquitin-protein ligase E3alpha.
Maturation of the hepatitis A virus capsid protein VP1 is not dependent on processing by the 3Cpro proteinase.
Polyprotein processing in cis and in trans by hepatitis A virus 3C protease cloned and expressed in Escherichia coli.
Processing of proteinase precursors and their effect on hepatitis A virus particle formation.
Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death.
Signals in hepatitis A virus P3 region proteins recognized by the ubiquitin-mediated proteolytic system.
Toward development of generic inhibitors against the 3C proteases of picornaviruses.
Hepatitis C
Exploring the binding mechanism of the main proteinase in SARS-associated coronavirus and its implication to anti-SARS drug design.
Herpes Simplex
Antiviral potential of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea.
Infections
A peptidyl aldehyde NK-1.8k suppresses EV71 and EV68 infection by targeting at 3Cpro.
A Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of V-7404 in Healthy Adult Volunteers.
A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection.
Aichi virus 3C protease modulates LC3- and SQSTM1/p62-involved antiviral response.
Cleavage of transcriptional activator Oct-1 by poliovirus encoded protease 3Cpro.
Design, synthesis and evaluation of 2,2-dimethyl-1,3-dioxolane derivatives as human rhinovirus 3C protease inhibitors.
Development of potent inhibitors of the coxsackievirus 3C protease.
DNA binding domain and subunit interactions of transcription factor IIIC revealed by dissection with poliovirus 3C protease.
Effect of T68A/N126Y mutations on the conformational and ligand binding landscape of Coxsackievirus B3 3C protease.
Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease.
Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.
EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.
Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis.
Foot-and-Mouth Disease Virus Evades Innate Immune Response by 3C-Targeting of MDA5.
hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.
Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist.
Intracellular redistribution of truncated La protein produced by poliovirus 3Cpro-mediated cleavage.
Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.
Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments.
Protease inhibitors as potential antiviral agents for the treatment of picornaviral infections.
Protective immune response in mice vaccinated with a recombinant adenovirus containing capsid precursor polypeptide P1, nonstructural protein 2A and 3C protease genes (P12A3C) of encephalomyocarditis virus.
Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease.
Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells.
Seneca Valley Virus 3C Protease Induces Pyroptosis by Directly Cleaving Porcine Gasdermin D.
Seneca Valley Virus 3C Protease Inhibits Stress Granule Formation by Disrupting eIF4GI-G3BP1 Interaction.
Seneca Valley Virus 3Cpro Cleaves PABPC1 to Promote Viral Replication.
Serological evidence of human klassevirus infection.
The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells.
Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene.
Influenza, Human
Benzophenone C-glucosides and gallotannins from mango tree stem bark with broad-spectrum anti-viral activity.
Leukemia
Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy.
Mouth Diseases
Foot and mouth disease leader protease (Lbpro): Investigation of prime side specificity allows the synthesis of a potent inhibitor.
Investigating the Substrate Specificity and Oligomerisation of the Leader Protease of Foot and Mouth Disease Virus using NMR.
Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle.
Susceptibility of inhibitors against 3C protease of coxsackievirus A16 and enterovirus A71 causing hand, foot and mouth disease: A molecular dynamics study.
Synthesis and Initial Evaluation of a Novel Fluorophore for Selective FMDV 3C Protease Detection.
Myocarditis
2,3,4-Trihydroxybenzyl-hydrazide analogues as novel potent coxsackievirus B3 3C protease inhibitors.
Antiviral activity of coxsackievirus B3 3C protease inhibitor in experimental murine myocarditis.
Development of anti-coxsackievirus agents targeting 3C protease.
Soluble Coxsackievirus B3 3C Protease Inhibitor Prevents Cardiomyopathy in an Experimental Chronic Myocarditis Murine Model.
Pericarditis
Development of anti-coxsackievirus agents targeting 3C protease.
Picornaviridae Infections
Porcine Picornavirus 3C Protease Degrades PRDX6 to Impair PRDX6-mediated Antiviral Function.
Porcine Reproductive and Respiratory Syndrome
Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1alpha.
Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist.
Porcine reproductive and respiratory syndrome virus 3C protease cleaves the mitochondrial antiviral signalling complex to antagonize IFN-? expression.
The effects of the context-dependent codon usage bias on the structure of the nsp1? of porcine reproductive and respiratory syndrome virus.
The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis.
Severe Acute Respiratory Syndrome
Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease.
Porcine Epidemic Diarrhea Virus 3C-Like Protease-Mediated Nucleocapsid Processing: Possible Link to Viral Cell Culture Adaptability.
Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review.
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.
Tuberculosis
Resisting resistant Mycobacterium tuberculosis naturally: Mechanistic insights into the inhibition of the parasite's sole signal peptidase Leader peptidase B.
Vaccinia
Expression of poliovirus P3 proteins using a recombinant vaccinia virus results in proteolytically active 3CD precursor protein without further processing to 3Cpro and 3Dpol.
Identification of active-site residues in protease 3C of hepatitis A virus by site-directed mutagenesis.
Virus Diseases
A Novel Enterovirus 71 (EV71) Virulence Determinant: The 69th Residue of 3C Protease Modulates Pathogenicity.
Inducible expression of encephalomyocarditis virus 3C protease activity in stably transformed mouse cell lines.
Modulation of stress granules and P bodies during dicistrovirus infection.
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP).
The Function and Mechanism of Enterovirus 71 (EV71) 3C Protease.