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Disease on EC 3.4.22.39 - adenain

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acromegaly
The imbalance of cathepsin B-like activity in acromegalic patients - preliminary report.
Adenocarcinoma
Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in chickens.
Expression of acid cysteine proteinase inhibitor (ACPI) in the normal human prostate, benign prostatic hyperplasia and adenocarcinoma.
Secretion of proteinases from malignant and nonmalignant human breast tissue.
Adenoma
Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas.
Adenoviridae Infections
Inhibition of adenovirus infection and adenain by green tea catechins.
Alveolar Bone Loss
Phytocystatin CsinCPI-2 Reduces Osteoclastogenesis and Alveolar Bone Loss.
Alzheimer Disease
Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients.
Conformational changes preceding amyloid-fibril formation of amyloid-beta and stefin B; parallels in pH dependence.
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Amebiasis
Cleavage of C3 by a neutral cysteine proteinase of Entamoeba histolytica.
Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene.
Contact of Entamoeba histolytica with baby hamster kidney-21 (BHK-21) cell line on cysteine proteinase activity.
Entamoeba histolytica: cloning, expression and evaluation of the efficacy of a recombinant amebiasis cysteine proteinase gene (ACP1) antigen in minipig.
Evaluation of the efficacy of a recombinant Entamoeba histolytica cysteine proteinase gene (EhCP5) antigen in Minipig.
Thiol proteinase expression and pathogenicity of Entamoeba histolytica.
Amyloidosis
The role of beta-amyloid in the development of Alzheimer's disease.
Two stable unfolding intermediates of the disease-causing L68Q variant of human cystatin C.
Amyotrophic Lateral Sclerosis
Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue.
Arthritis
Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro.
Blocking of experimental arthritis by cleavage of IgG antibodies in vivo.
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Cysteine proteinase activity in the development of arthritis in an adjuvant model of the rat.
Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis.
Immunohistochemical demonstration of calcium-dependent cysteine proteinase (calpain) in collagen-induced arthritis in mice.
Arthritis, Experimental
Immunohistochemical demonstration of calcium-dependent cysteine proteinase (calpain) in collagen-induced arthritis in mice.
Arthritis, Rheumatoid
Amelioration of experimental arthritis by a calpain-inhibitory compound: regulation of cytokine production by E-64-d in vivo and in vitro.
Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis.
Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.
Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis.
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Asthma
Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: insight into therapeutic potential.
Expression cloning of a dust mite cysteine proteinase, Der p1, a major allergen associated with asthma and hypersensitivity reactions.
Astrocytoma
Lysosomal enzymes, cathepsins in brain tumour invasion.
The clinical significance of cathepsin S expression in human astrocytomas.
Atherosclerosis
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Mast cells promote atherosclerosis by releasing proinflammatory cytokines.
[Lysosomes in cellular activity. Physiology and pathology]
Bacterial Infections
Neutrophil chemotactic activity is modulated by human cystatin C, an inhibitor of cysteine proteases.
Blast Crisis
c-MYB is a transcriptional regulator of ESPL1/Separase in BCR-ABL-positive chronic myeloid leukemia.
Blister
Proteases are responsible for blister formation in recessive dystrophic epidermolysis bullosa and epidermolysis bullosa simplex.
Bone Resorption
A peptidyl derivative structurally based on the inhibitory center of cystatin C inhibits bone resorption in vitro.
A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts.
Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits.
Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy.
Cystatin B as an intracellular modulator of bone resorption.
Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.
Effects of an inhibitor of cathepsin L on bone resorption in thyroparathyroidectomized and ovariectomized rats.
Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma.
Expression of the proteinase specialized in bone resorption, cathepsin K, in granulomatous inflammation.
Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy.
Increased numbers of osteoclasts expressing cysteine proteinase cathepsin K in patients with infected osteoradionecrosis and bisphosphonate-associated osteonecrosis-a paradoxical observation?
Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors.
Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.
Potential role of cathepsin K in the pathophysiology of mucopolysaccharidoses.
The collagenolytic activity of cathepsin K is unique among mammalian proteinases.
Brain Ischemia
Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties.
Brain Neoplasms
Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors.
Breast Neoplasms
A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B.
A latent form of cathepsin B in pleural effusions. I. Characterization of the enzyme in breast cancer patients.
Cathepsin B in human breast tumor tissue and cancer cells.
Cathepsins B, H and L in human breast carcinoma.
CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.
Characterization of a thiol proteinase secreted by malignant human breast tumours.
Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro.
Cysteine proteinase inhibitor cystatin A in breast cancer.
Demonstration of cysteine proteinase inhibitors ACPI and NCPI in breast cancer and in cell lines MCF-7 and ZR-75-1.
Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell lines.
Human cathepsin O. Molecular cloning from a breast carcinoma, production of the active enzyme in Escherichia coli, and expression analysis in human tissues.
Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer.
Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.
Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors.
Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization.
Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C.
SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ER?-positive breast cancer through regulation of BRCA1.
Studies on thiol protease inhibitor isolated from human breast cancer tissue.
Burkitt Lymphoma
In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64.
Carcinoma
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).
Acid and neutral cysteine proteinase inhibitor in normal uterine portio and in squamo-epithelial metaplasia, dysplasias and infiltrative carcinoma of the uterine portio.
Adenovirus endopeptidase hydrolyses human squamous cell carcinoma antigens in vitro but not ex vivo.
Cathepsin B and D expression in squamous cell carcinoma.
Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.
Cathepsins B, H, L and cysteine proteinase inhibitors in renal cell carcinoma: no evidence for dysregulated proteolytic balance.
Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation.
Cystatins and stefins in ascites fluid from ovarian carcinoma.
Cysteine endopeptidase activity levels in normal human tissues, colorectal adenomas and carcinomas.
Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of the head and neck: relation to prognosis.
Cysteine proteinase inhibitors in human squamous cell carcinoma.
Cysteine proteinases produced by cultured rabbit V2 carcinoma cells and rabbit skin fibroblasts.
Effects of combined in vivo treatment of transplantable solid mammary carcinoma in wistar rats using vitamin E and cysteine peptidase inhibitors from human placenta.
Equistatin, a new inhibitor of cysteine proteinases from Actinia equina, is structurally related to thyroglobulin type-1 domain.
Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma.
Extracellular cysteine proteinase and collagenase activities as a consequence of tumor-host interaction in the rabbit V2 carcinoma.
gamma-Glutamyl carboxylase activity in experimental tumor tissues: a biochemical basis for vitamin K dependence of cancer procoagulant.
Human breast and colon carcinomas express cysteine proteinase activities with pro-aggregating and pro-coagulant properties.
In vivo circumvention of human colon carcinoma resistance to bleomycin.
In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64.
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.
Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.
Multiple forms of cathepsin B in human lung cancer.
Photodynamic therapy combined with a cysteine proteinase inhibitor synergistically decrease VEGF production and promote tumour necrosis in a rat mammary carcinoma.
Proteasome inhibitors modulate chemokine production in lung epithelial and monocytic cells.
Proteinase activity in invasive cancer of the breast. Correlation with tumor progression.
Secretion of a thiol proteinase from mouse mammary carcinomas and its characterization.
Serum cystatin C in patients with head and neck carcinoma.
Several murine metastasizing tumors possess a cysteine proteinase with cancer procoagulant characteristics.
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
The activities and subcellular localization of cathepsin B and cysteine proteinase inhibitors in human ovarian carcinoma.
The combined treatment of transplantable solid mammary carcinoma in Wistar rats by use of photodynamic therapy and cysteine proteinase inhibitor.
The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.
The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1.
[Potential use of cysteine endopeptidase inhibitors in radiodiagnostics of laryngeal and tongue neoplasms]
[Preliminary study on the expression of cystatin C in primary liver cancer].
Carcinoma, Ehrlich Tumor
Differential sensitivity of vimentin and nuclear lamins from Ehrlich ascites tumor cells toward Ca2+ -activated neutral thiol proteinase.
Efficient degradation in vitro of all intermediate filament subunit proteins by the Ca2+-activated neutral thiol proteinase from Ehrlich ascites tumor cells and porcine kidney.
Large scale isolation, purification, and partial characterization of the intermediate filament-specific, Ca2+-activated proteinase from porcine kidney and Ehrlich ascites tumor cells: a comparative study.
Carcinoma, Hepatocellular
Comparison of the acute phase response of cultured Morris hepatoma 7777 cells and of rat hepatocytes.
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis.
Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats.
Effects of dexamethasone and insulin on the acute phase response of Morris hepatoma cells and of rat hepatocytes in culture.
Role of cytokines and growth factors in the induced synthesis of proteinase inhibitors belonging to acute phase proteins.
Carcinoma, Renal Cell
Cathepsins B, H, L and cysteine proteinase inhibitors in renal cell carcinoma: no evidence for dysregulated proteolytic balance.
Carcinoma, Squamous Cell
Acid and neutral cysteine proteinase inhibitor in normal uterine portio and in squamo-epithelial metaplasia, dysplasias and infiltrative carcinoma of the uterine portio.
Adenovirus endopeptidase hydrolyses human squamous cell carcinoma antigens in vitro but not ex vivo.
Cathepsin B and D expression in squamous cell carcinoma.
Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of the head and neck: relation to prognosis.
Cysteine proteinase inhibitors in human squamous cell carcinoma.
Serum cystatin C in patients with head and neck carcinoma.
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.
The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1.
Carcinoma, Transitional Cell
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).
Cardiomegaly
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.
Cardiomyopathy, Dilated
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
Cardiovascular Diseases
Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study.
Cataract
Age-related changes of calpain II and alpha-crystallin in the lens of hereditary cataract (Nakano) mouse.
Celiac Disease
Rational Design of Recombinant Papain-Like Cysteine Protease: Optimal Domain Structure and Expression Conditions for Wheat-Derived Enzyme Triticain-?.
Targeted modification of wheat grain protein to reduce the content of celiac causing epitopes.
Cerebral Hemorrhage
Human cysteine proteinase inhibitors. Isolation, physiological importance, inhibitory mechanism, gene structure and relation to hereditary cerebral hemorrhage.
Chagas Disease
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.
Cruzain : the path from target validation to the clinic.
Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptors.
Chediak-Higashi Syndrome
A thiol proteinase inhibitor, E-64-d, corrects the abnormalities in concanavalin A cap formation and the lysosomal enzyme activity in leucocytes from patients with Chediak-Higashi syndrome by reversing the down-regulated protein kinase C activity.
Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.
Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.
Thiol proteinase inhibitors reverse the increased protein kinase C down-regulation and concanavalin A cap formation in polymorphonuclear leukocytes from Chediak-Higashi syndrome (beige) mouse.
Cholesteatoma
Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma.
Chronic Periodontitis
Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients.
Porphyromonas gingivalis-induced IL-33 down-regulates hCAP-18/LL-37 production in human gingival epithelial cells.
Clonorchiasis
Expression of cysteine proteinase of Clonorchis sinensis and its use in serodiagnosis of clonorchiasis.
Molecular expression of a cysteine proteinase of Clonorchis sinensis and its application to an enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis.
Clostridium Infections
A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters.
Colonic Neoplasms
An inactive cathepsin B-like enzyme and cysteine proteinase inhibitors in colon cancer ascites.
Colorectal Neoplasms
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
Cysteine peptidase and its inhibitor activity levels and vitamin E concentration in normal human serum and colorectal carcinomas.
Cysteine peptidase inhibitors and activator(s) in urine of patients with colorectal cancer.
Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis.
Expression of cystatin C in clinical human colorectal cancer tissues.
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Coronary Disease
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Coronavirus Infections
Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection.
Cysticercosis
Cysteine proteinase inhibitors in murine cysticercosis.
Cysts
Cathepsin-k expression in pulmonary lymphangioleiomyomatosis.
Characterization of a cysteine proteinase from Taenia crassiceps cysts.
DNA Methylation of Gene Expression in Acanthamoeba castellanii Encystation.
Effective transgenic resistance to Globodera pallida in potato field trials.
Entamoeba invadens: characterization of cysteine proteinases.
Immunodetection of thiol proteinase levels in various populations of Artemia cysts and during development.
Isolation and characterization of a cDNA clone encoding a thiol proteinase of Sarcocystis muris cyst mero' zoites (Apicomplexa).
The activity of a developmentally regulated cysteine proteinase is required for cyst wall formation in the primitive eukaryote Giardia lamblia.
Dehydration
Analysis of the protein expression profiling during rice callus differentiation under different plant hormone conditions.
Retargeting of a Plant Defense Protease by a Cyst Nematode Effector.
Dermatitis
Activation mechanism of thiol protease precursor from broiler chicken specific Staphylococcus aureus strain CH-91.
Diabetes Mellitus, Type 2
Changes in membrane microenvironment and signal transduction in platelets from NIDDM patients-a pilot study.
Echinococcosis
Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection.
Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.
Encephalitis
Isolation and characterization of a cDNA encoding a mammalian cathepsin L-like cysteine proteinase from Acanthamoeba healyi.
Endometrial Hyperplasia
Autophagy in the physiological endometrium and cancer.
Endometrial Neoplasms
Autophagy in the physiological endometrium and cancer.
Fascioliasis
Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase.
Short report: Immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase.
Fibrosarcoma
Cystatin C and cathepsin B in human colon carcinoma: expression by cell lines and matrix degradation.
Foot-and-Mouth Disease
Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus.
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate.
Uncovering targets of the Leader protease: Linking RNA-mediated pathways and antiviral defense.
Frontotemporal Lobar Degeneration
Cryptic exon splicing function of TARDBP interacts with autophagy in nervous tissue.
Giant Cell Tumor of Tendon Sheath
Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath.
Giant Cell Tumors
Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath.
Glioblastoma
MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy.
Glioma
Lysosomal enzymes, cathepsins in brain tumour invasion.
MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy.
Secretion of cathepsin B by human gliomas in vitro.
Glomerulonephritis
Is the nephritogenic antigen in post-streptococcal glomerulonephritis pyrogenic exotoxin B (SPE B) or GAPDH?
The cysteine proteinase inhibitor, E-64, reduces proteinuria in an experimental model of glomerulonephritis.
Hepatitis
Determinants of mouse hepatitis virus 3C-like proteinase activity.
Hepatitis A
A fluorescent protein-based biological screen of proteinase activity.
An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors.
Beta-lactones as a new class of cysteine proteinase inhibitors: inhibition of hepatitis A virus 3C proteinase by N-Cbz-serine beta-lactone.
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors.
Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase.
Synthesis and testing of azaglutamine derivatives as inhibitors of hepatitis A virus (HAV) 3C proteinase.
Hepatitis E
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease.
Expression and processing of the Hepatitis E virus ORF1 nonstructural polyprotein.
Hepatitis E Virus Papain-Like Cysteine Protease Inhibits Type I Interferon Induction by Down-Regulating Melanoma Differentiation-Associated Gene 5.
Molecular characterization of hepatitis E virus ORF1 gene supports a papain-like cysteine protease (PCP)-domain activity.
Molecular modeling and analysis of hepatitis E virus (HEV) papain-like cysteine protease.
The Amino-Terminal Region of Hepatitis E Virus ORF1 Containing a Methyltransferase (Met) and a Papain-Like Cysteine Protease (PCP) Domain Counteracts Type I Interferon Response.
Herpes Simplex
Proteinase inhibition, immunoglobulin-binding proteins and a novel antimicrobial principle.
Herpes Zoster
Inhibition of in-vitro fertilization of hamster oocytes by a thiol proteinase inhibitor.
Hyperinsulinism
Insulin resistance is mediated by a proteolytic fragment of the insulin receptor.
Hypersensitivity
A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi as an antigen for delayed-type hypersensitivity assays and serodiagnosis of canine visceral leishmaniasis.
Allergy to ginger with cysteine proteinase GP-I as the relevant allergen.
Comparative enzymology of native and recombinant house dust mite allergen Der p 1.
Comparative modelling of major house dust mite allergen Der p I: structure validation using an extended environmental amino acid propensity table.
Cysteine proteinase inhibitor Act d 4 is a functional allergen contributing to the clinical symptoms of kiwifruit allergy.
Enzymatically active papain preferentially induces an allergic response in mice.
Expression cloning of a dust mite cysteine proteinase, Der p1, a major allergen associated with asthma and hypersensitivity reactions.
Hypertension
The brown Norway rats and the kinin system.
Impetigo
Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci.
Infections
A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters.
A Plasmodium cysteine protease required for efficient transition from the liver infection stage.
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Antibody to streptococcal cysteine proteinase as a seromarker of group A Streptococcal (Streptococcus pyogenes) infections.
Arachidonic Acid Is a Safe and Efficacious Schistosomicide, and an Endoschistosomicide in Natural and Experimental Infections, and Cysteine Peptidase Vaccinated Hosts.
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.
C-Terminal Domain Deletion Enhances the Protective Activity of cpa/cpb Loaded Solid Lipid Nanoparticles against Leishmania major in BALB/c Mice.
Cathepsin B-like cysteine proteinase activity in sputum and bronchoalveolar lavage samples: relationship to inflammatory cells and effects of corticosteroids and antibiotic treatment.
Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection.
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction.
Chemotactic and protease-inhibiting activities of antibiotic peptide precursors.
Circadian expression and induction by wounding of tobacco genes for cysteine proteinase.
Comparative Study of the Ability of Leishmania mexicana Promastigotes and Amastigotes to Alter Macrophage Signalling and Functions.
Cystatins up-regulate nitric oxide release from interferon-gamma-activated mouse peritoneal macrophages.
Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals.
Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.
Differential diagnosis of Trypanosoma cruzi and T. rangeli infection by PCR of cysteine proteinase genes.
Discovery and structure-based optimization of adenain inhibitors.
Discovery of small molecule PLpro inhibitor against COVID-19 using structure-based virtual screening, molecular dynamics simulation, and molecular mechanics/Generalized Born surface area (MM/GBSA) calculation.
Dynamics of speB mRNA Transcripts in Streptococcus pyogenes.
Effect of a thiol proteinase inhibitor, E-64-d, on susceptibility to infection with Staphylococcus aureus in Chediak-Higashi syndrome (beige) mice.
Electrophoretic and spectral characterization of wild type and mutant adenovirus protease.
Entamoeba histolytica: cloning, expression and evaluation of the efficacy of a recombinant amebiasis cysteine proteinase gene (ACP1) antigen in minipig.
Evaluation of the efficacy of a recombinant Entamoeba histolytica cysteine proteinase gene (EhCP5) antigen in Minipig.
Evaluation of the immune response of male and female rats vaccinated with cDNA encoding a cysteine proteinase of Fasciola hepatica (FhPcW1).
Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis.
Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimental fasciolosis in ruminants.
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.
Immune response of rats vaccinated orally with various plant-expressed recombinant cysteine proteinase constructs when challenged with Fasciola hepatica metacercariae.
Immunization with the cysteine proteinase Ldccys1 gene from Leishmania (Leishmania) chagasi and the recombinant Ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis.
Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases.
Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase.
Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway.
Intracellular differentiation of Leishmania amazonensis promastigotes to amastigotes: presence of megasomes, cysteine proteinase activity and susceptibility to leucine-methyl ester.
Investigation of arginine A-specific cysteine proteinase gene expression profiling in clinical Porphyromonas gingivalis isolates against photokilling action of the photo-activated disinfection.
Isolation, Identification, and Evaluation of the Pathogenicity of a Porcine Enterovirus G Isolated From China.
Loop-mediated isothermal amplification method for differentiation and rapid detection of Taenia species.
Modulating the proteinase inhibitory profile of a plant cystatin by single mutations at positively selected amino acid sites.
Parasite cysteine proteinase interactions with alpha2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids.
Protection studies in sheep using affinity-purified and recombinant cysteine proteinases of adult Haemonchus contortus.
Protective Cellular Immune Response Induction for Cutaneous Leishmaniasis by a New Immunochemotherapy Schedule.
Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase.
Proteinase activity in miracidia, transformation excretory-secretory products, and primary sporocysts of Schistosoma mansoni.
Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium.
Purification and partial characterization of cysteine proteinase from Spirometra mansoni plerocercoids.
Reovirus virion-like particles obtained by recoating infectious subvirion particles with baculovirus-expressed sigma3 protein: an approach for analyzing sigma3 functions during virus entry.
Role for a secreted cysteine proteinase in the establishment of host tissue tropism by group A streptococci.
Streptococcal pyrogenic exotoxin A, streptolysin O, exoenzymes, serotype and biotype profiles of Streptococcus pyogenes isolates from patients with toxic shock syndrome and other severe infections.
Th1 and Th2 immunological profile induced by cysteine proteinase in murine leishmaniasis.
The C-terminal extension of Leishmania pifanoi amastigote-specific cysteine proteinase Lpcys2: A putative function in macrophage infection.
The Cleaved N-Terminus of pVI Binds Peripentonal Hexons in Mature Adenovirus.
The immune response of rats to vaccination with the cDNA or protein forms of the cysteine proteinase of Fasciola hepatica.
The role of Schistosoma mansoni males in feeding and development of female worms.
Toxopain-1 is critical for infection in a novel chicken embryo model of congenital toxoplasmosis.
Vaccine potential of inclusion bodies containing cysteine proteinase of Fasciola hepatica in calves and lambs experimentally challenged with metacercariae of the fluke.
[Influence of vaccination of calves with recombinant cysteine proteinase of Fasciola hepatica on development and infectivity of miracidia]
[The occurrence of fasciola hepatica in chosen regions of Poland based on molecular and serological methods]
Infertility, Male
Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing.
Inflammatory Bowel Diseases
Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-induced experimental inflammatory bowel disease in mice.
Insulin Resistance
Insulin resistance is mediated by a proteolytic fragment of the insulin receptor.
Intestinal Volvulus
Molecular cloning and characterization of onchocystatin, a cysteine proteinase inhibitor of Onchocerca volvulus.
The Onchocerca volvulus cysteine proteinase inhibitor, Ov-CPI-2, is a target of protective antibody response that increases with age.
Intracranial Hemorrhages
Molecular diagnosis of hereditary cystatin C amyloid angiopathy.
Joint Diseases
Effect of selected antirheumatic drugs on the metabolism of cartilage and synovial tissue in experimental arthropathy.
Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint diseases.
Leishmaniasis
Leishmanial amastigote antigen P-2 induces major histocompatibility complex class II-dependent natural killer-cell reactivity in cells from healthy donors.
Th1 and Th2 immunological profile induced by cysteine proteinase in murine leishmaniasis.
Leishmaniasis, Cutaneous
Enhancement of Th1 immune response against Leishmania cysteine peptidase A, B by PLGA nanoparticle.
NO donors inhibit Leishmania infantum cysteine proteinase activity.
Partial protective responses induced by a recombinant cysteine proteinase from Leishmania (Leishmania) amazonensis in a murine model of cutaneous leishmaniasis.
Leishmaniasis, Visceral
A novel antigen, otubain cysteine peptidase of Leishmania donovani improves serodiagnosis of visceral leishmaniasis and monitors treatment response.
A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi as an antigen for delayed-type hypersensitivity assays and serodiagnosis of canine visceral leishmaniasis.
A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis.
Cysteine proteinase type III is protective against Leishmania infantum infection in BALB/c mice and highly antigenic in visceral leishmaniasis individuals.
Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis.
Immunization with the cysteine proteinase Ldccys1 gene from Leishmania (Leishmania) chagasi and the recombinant Ldccys1 protein elicits protective immune responses in a murine model of visceral leishmaniasis.
Retraction: Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis.
Use of a Recombinant Cysteine Proteinase from Leishmania (Leishmania) infantum chagasi for the Immunotherapy of Canine Visceral Leishmaniasis.
Leukemia
A new procoagulant in acute leukemia.
Cancer procoagulant in acute lymphoblastic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Puncta intended: connecting the dots between autophagy and cell stress networks.
Liver Abscess
Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice.
Liver Abscess, Amebic
Amebic cysteine proteinase 2 (EhCP2) plays either a minor or no role in tissue damage in acute experimental amebic liver abscess in hamsters.
Contact of Entamoeba histolytica with baby hamster kidney-21 (BHK-21) cell line on cysteine proteinase activity.
Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters.
Entamoeba histolytica: rapid detection of indian isolates by cysteine proteinase gene-specific polymerase chain reaction.
Overexpression of cysteine proteinase 2 in Entamoeba histolytica or Entamoeba dispar increases amoeba-induced monolayer destruction in vitro but does not augment amoebic liver abscess formation in gerbils.
Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice.
Liver Neoplasms
Characterization of cathepsin B-like proteinase from ascitic fluid of patients with primary liver cancer.
Lung Injury
Benzo(a)pyrene induced structural and functional modifications in lung cystatin.
Cathepsins in bleomycin-induced lung injury in rat.
Lung Neoplasms
Biological and prognostic role of acid cysteine proteinase inhibitor (ACPI, cystatin A) in non-small-cell lung cancer.
Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of lung cancer patients.
Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines.
Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking.
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Purification of thiol protease inhibitor from human lung cancer tissue.
[Behavior of small molecular cysteine proteinase inhibitors in lung cancers and surrounding tissue]
Lymphadenopathy
Dendritic reticulum cells in AIDS-related lymphadenopathy.
Lymphangioleiomyomatosis
Cathepsin-k expression in pulmonary lymphangioleiomyomatosis.
Lymphoma
N-terminus cleavage of bcl-2 by a novel cellular non-ICE cysteine proteinase.
Lymphoma, B-Cell
Dipeptide processing activates recombinant human prochymase.
Lymphoma, Non-Hodgkin
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis.
Malaria
A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue.
Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases.
Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites.
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
Melanoma
A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma.
A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells.
A thiol protease inhibitor released from cultured human malignant melanoma cells.
Antitumor effects in vitro and in vivo and mechanisms of protection against melanoma B16F10-Nex2 cells by fastuosain, a cysteine proteinase from Bromelia fastuosa.
Cancer procoagulant in human tumor cells: evidence from melanoma patients.
Clinical relevance of cathepsin B-like enzyme activity and cysteine proteinase inhibitor in melanocytic tumours.
Co-expression and secretion of C3, the third component of complement and a C3-cleaving cysteine proteinase in a highly metastatic human melanoma cell line.
Cysteine proteinase inhibitors in human melanoma transplanted into nude mice.
Cysteine proteinase inhibitors reduce malignant melanoma cell invasion in vitro.
Diversity of melanoma plasma membrane proteinases: inhibition of collagenolytic and cytolytic activities by minocycline.
Hepatitis E Virus Papain-Like Cysteine Protease Inhibits Type I Interferon Induction by Down-Regulating Melanoma Differentiation-Associated Gene 5.
Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L.
Inhibition of motility and invasion of B16 melanoma by the overexpression of cystatin C.
Melanosomal and lysosomal alterations in murine melanocytes following transfection with the v-rasHa oncogene.
Structure and functions of proteases which cleave human C3 and are expressed on normal or tumor human cells: some are involved in tumorigenic and metastatic properties of human melanoma cells.
Tumor-associated cysteine proteinase activities in human melanoma cells and fibroblasts of different origin.
Melanoma, Amelanotic
Cathepsin B-like activity in viable tumor cells isolated from rodent tumors.
Tumor cell membrane cathepsin B.
Melanoma, Experimental
Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro.
Induction and inhibition of cathepsin B and hemoglobin-hydrolase activity in murine B16 melanoma by thiol protease inhibitors.
Inhibition of B16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C.
Involvement of calpain in melanogenesis of mouse B16 melanoma cells.
Meningioma
Cathepsins B and L are markers for clinically invasive types of meningiomas.
Lysosomal enzymes, cathepsins in brain tumour invasion.
Mouth Diseases
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E.
Multiple Sclerosis
A thiol proteinase highly elevated in and around the plaques of multiple sclerosis. Some biochemical parameters of plaque activity and progression.
Muscular Diseases
Experimental chloroquine myopathy: morphological and biochemical studies.
Trial of a cysteine proteinase inhibitor, EST, in experimental chloroquine myopathy in rats.
[The therapeutic effect of cysteine proteinase inhibitor, EST, on experimental chloroquine myopathy]
Muscular Dystrophies
Age-related changes and tissue distribution of parvalbumin in normal and dystrophic mice of strain 129 ReJ.
Effects of the protease inhibitor leupeptin on proteolytic activities and regeneration of mouse skeletal muscles after exercise injuries.
Evidence for a defective thiol protease inhibitor in skeletal muscle of mice with hereditary muscular dystrophy.
Neoplasm Metastasis
A cysteine proteinase, which cleaves human C3, the third component of complement, is involved in tumorigenicity and metastasis of human melanoma.
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level.
Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.
Cathepsin B in human breast tumor tissue and cancer cells.
Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma.
Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Cathepsin B levels in urine from bladder cancer patients.
Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Expression of cathepsin D during the progression of human gliomas.
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells.
Inhibition of B16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C.
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridization.
Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.
Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity.
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice.
Secretion of proteinases from malignant and nonmalignant human breast tissue.
Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C.
[A study on cathepsin B-like substance in cancer of the urinary tract]
Neoplasms
A factor X-activating cysteine protease from malignant tissue.
A latent thiol proteinase from ascitic fluid of patients with neoplasia.
A new procoagulant in acute leukemia.
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors.
A possible mechanism for the long-lasting antitumor effect of the macromolecular conjugate DE-310: mediation by cellular uptake and drug release of its active camptothecin analog DX-8951.
A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cells.
A systematic bioinformatics approach for selection of target and screening of ligand for malignant tumours suppressing APG4A gene on Xq22.1.
Activity of cysteine proteases and their inhibitors in the lymph nodes of larynx cancer patients.
Addition of 2-(ethylamino)acetonitrile group to nitroxoline results in significantly improved anti-tumor activity in vitro and in vivo.
An enzyme-linked immunosorbent assay for cancer procoagulant and its potential as a new tumor marker.
Autophagy drives fibroblast senescence through MTORC2 regulation.
Autophagy in the physiological endometrium and cancer.
Biochemical, immunological and kinetic characterisation of thiol protease inhibitor (cystatin) from liver.
Biochemistry of cancer procoagulant.
Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis.
Blood coagulation changes in nude mice bearing human colon carcinomas.
Cancer procoagulant in acute lymphoblastic leukemia.
Cancer procoagulant in patients with adenocarcinomas.
Cancer procoagulant.
Capn3 depletion causes Chk1 and Wee1 accumulation and disrupts synchronization of cell cycle reentry during liver regeneration after partial hepatectomy.
Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level.
Cathepsin B and cystatins: evidence for a role in cancer progression.
Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of lung cancer patients.
Cathepsin B and D expression in squamous cell carcinoma.
Cathepsin B and its endogenous inhibitors: the role in tumor malignancy.
Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors.
Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.
Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma.
Cathepsin B in the growth of colorectal cancer: increased activity of cathepsin B in human colorectal cancer.
Cathepsin B in the growth of colorectal cancer: suppressive effect of leupeptin on the growth of DMH-induced rat colon neoplasm.
Cathepsin B levels in urine from bladder cancer patients.
Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.
Cathepsin B-like activity in viable tumor cells isolated from rodent tumors.
Cathepsin K is Superior to HMB45 for the Diagnosis of Pulmonary Lymphangioleiomyomatosis.
Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Characterization of a cysteine proteinase secreted by mouse mammary gland.
Characterization of a latent cysteine proteinase from ascitic fluid as a high molecular weight form of cathepsin B.
Clinical relevance of cathepsin B-like enzyme activity and cysteine proteinase inhibitor in melanocytic tumours.
Clioquinol-ruthenium complex impairs tumour cell invasion by inhibiting cathepsin B activity.
Co-expression and secretion of C3, the third component of complement and a C3-cleaving cysteine proteinase in a highly metastatic human melanoma cell line.
Comparative studies of mouse liver cathepsin B and an analogous tumor thiol proteinase.
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Correlation between serum cathepsin S and insulin resistance in type 2 diabetes.
Cystatins and cathepsins in breast carcinoma.
Cystatins in cancer progression: More than just cathepsin inhibitors.
Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking.
Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of the head and neck: relation to prognosis.
Cysteine proteinase inhibitor in the ascitic fluid of sarcoma 180 tumor-bearing mice is a low molecular weight kininogen. Partial NH2- and COOH-terminal sequences and susceptibility to various glandular kallikreins.
Cysteine proteinase inhibitor level in tumor and normal tissues in control and cured mice.
Cysteine proteinase inhibitors in human melanoma transplanted into nude mice.
Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis.
Cysteine proteinase procoagulant from amnion-chorion.
Cysteine proteinases and metastasis.
Cysteine proteinases produced by cultured rabbit V2 carcinoma cells and rabbit skin fibroblasts.
Decrease in vivo of cysteine endopeptidases in blood of patients with tumor of the larynx.
Degradation of laminin by human tumor cathepsin B.
Differential expression of genes in resistant versus susceptible Gyr x Holstein cattle challenged with the tick Rhipicephalus (Boophilus) microplus.
Differential sensitivity of vimentin and nuclear lamins from Ehrlich ascites tumor cells toward Ca2+ -activated neutral thiol proteinase.
Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats.
Efficient degradation in vitro of all intermediate filament subunit proteins by the Ca2+-activated neutral thiol proteinase from Ehrlich ascites tumor cells and porcine kidney.
Employing in vitro analysis to test the potency of methylglyoxal in inducing the formation of amyloid-like aggregates of caprine brain cystatin.
Enrichment of collagen and gelatin degrading activities in the plasma membranes of human cancer cells.
Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors.
Evidence of a warfarin-sensitive cancer procoagulant in V2 carcinoma.
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Expression of cathepsin D and B in invasion and metastasis of squamous cell carcinoma.
Expression of cathepsin D during the progression of human gliomas.
Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath.
Extracellular cysteine proteinase and collagenase activities as a consequence of tumor-host interaction in the rabbit V2 carcinoma.
Fungal lectin MpL enables entry of protein drugs into cancer cells and their subcellular targeting.
High expression of the cysteine proteinase legumain in colorectal cancer - implications for therapeutic targeting.
Human breast and colon carcinomas express cysteine proteinase activities with pro-aggregating and pro-coagulant properties.
Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy.
Identification and characterization of the novel reversible and selective cathepsin X inhibitors.
Immunohistochemical study of cathepsin B. Prognostic significance in human lung cancer.
Increased cathepsin B activity in human lung tumors.
Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines.
Inhibition of B16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C.
Inhibition of cancer procoagulant by peptidyl diazomethyl ketones and peptidyl sulfonium salts.
Inhibition of cathepsin B activity in human breast cancer tissue by cysteine peptidase inhibitor isolated from human placenta: immunohistochemical and biochemical studies.
Isolation and characterization of cancer procoagulant: a cysteine proteinase from malignant tissue.
Large scale isolation, purification, and partial characterization of the intermediate filament-specific, Ca2+-activated proteinase from porcine kidney and Ehrlich ascites tumor cells: a comparative study.
Legumain correlates with neuroblastoma differentiation and can be used in prodrug design.
Limited effects of recombinant human and murine interleukin 1 and tumour necrosis factor on production of acute phase proteins by cultured rat hepatocytes.
Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridization.
Localization of cathepsin B in two human lung cancer cell lines.
Macrophage Stimulator beta-(1-->3)-D-carboxymethylglucan improves the efficiency of chemotherapy of Lewis lung carcinoma.
Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth.
Mechanisms of human bladder tumor invasion: role of protease cathepsin B.
MIR93 (microRNA -93) regulates tumorigenicity and therapy response of glioblastoma by targeting autophagy.
New Anti-Cancer Strategy to Suppress Colorectal Cancer Growth Through Inhibition of ATG4B and Lysosome Function.
Occurrence of acid and neutral cysteine proteinase inhibitors in epidermal malignancies: immunohistochemical study.
Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity.
Photodynamic therapy combined with a cysteine proteinase inhibitor synergistically decrease VEGF production and promote tumour necrosis in a rat mammary carcinoma.
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent.
Protein changes in the albedo of citrus fruits on postharvesting storage.
Proteinase activity in invasive cancer of the breast. Correlation with tumor progression.
Proteinases and proteinase inhibition by cytotoxic and antimetastatic drugs in transplantable solid metastasizing tumors in mice.
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice.
Regulation of synthesis and secretion of major rat acute-phase proteins by recombinant human interleukin-6 (BSF-2/IL-6) in hepatocyte primary cultures.
Role for different cell proteinases in cancer invasion and cytolysis.
Role of cysteine endopeptidases in cancerogenesis.
Role of phosphoinositide 3-kinase in adhesion of platelets to fibrinogen stimulated by cancer procoagulant.
Secretion of proteinases from malignant and nonmalignant human breast tissue.
Several murine metastasizing tumors possess a cysteine proteinase with cancer procoagulant characteristics.
Stefins and lysosomal cathepsins B, L and D in human breast carcinoma.
Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1.
Synergistic induction of anchorage-independent growth of NIH3T3 mouse fibroblasts by cysteine proteinase inhibitors and a tumor promoter.
Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides.
The clinical significance of cathepsin S expression in human astrocytomas.
The current stage of cathepsin B inhibitors as potential anticancer agents.
The effect of nitrogen source on yield and glycosylation of a human cystatin C mutant expressed in Pichia pastoris.
The effect of Z-FA.FMK on D-galactosamine/TNF-alpha-induced liver injury in mice.
The half-life of human procathepsin S.
The influence of Ukrain on the growth of HA-1 tumor in mice: the role of cysteine proteinases as markers of tumor malignancy.
The purification and properties of cancer procoagulant from murine tumors.
The role of cystatin C as a proteasome inhibitor in multiple myeloma.
The site of activation of factor X by cancer procoagulant.
Three-stage chromogenic assay for the analysis of activation properties of factor X by cancer procoagulant.
Thromboxane production by platelets during tumor cell-induced platelet activation.
Tumor progression and metastasis in murine D2 hyperplastic alveolar nodule mammary tumor cell lines.
[A study on cathepsin B-like substance in cancer of the urinary tract]
[Assay of urine cysteine proteinase in diagnosing gynecological malignant tumors]
[Cancer procoagulant activity in serum and neoplastic tissue in cases of cervical and uterine carcinoma]
[Cathepsin B and pro-drug activation]
Neuroblastoma
Degradation of luteinizing hormone-releasing hormone by neuroblastoma cells and their membrane: evidence for the involvement of a thiol protease and angiotensin-converting enzyme.
Involvement of diacylglycerol produced by phospholipase D activation in A?-induced reduction of sAPP? secretion in SH-SY5Y neuroblastoma cells.
The thiol proteinase inhibitor E-64-d ameliorates amyloid-?-induced reduction of sAPP? secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells.
Neurodegenerative Diseases
Identification and characterization of the novel reversible and selective cathepsin X inhibitors.
Mammalian cystatin and protagonists in brain diseases.
Osteoarthritis
Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis.
Cytoskeletal architecture and cathepsin B trafficking in human articular chondrocytes.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Temporal pattern of cysteine endopeptidase (cathepsin B) expression in cartilage and synovium from rabbit knees with experimental osteoarthritis: gene expression in chondrocytes in response to interleukin-1 and matrix depletion.
Osteochondrodysplasias
The genetic basis of the osteochondrodysplasias.
Osteoporosis
A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.
An allosteric site enables fine-tuning of cathepsin K by diverse effectors.
An orally active cathepsin K inhibitor, furan-2-carboxylic acid, 1-{1-[4-fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), inhibits osteoclast activity in vitro and bone loss in ovariectomized rats.
Carbon-11 labeled cathepsin K inhibitors: Syntheses and preliminary in vivo evaluation.
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Changes in micro-CT 3D bone parameters reflect effects of a potent cathepsin K inhibitor (SB-553484) on bone resorption and cortical bone formation in ovariectomized mice.
Osteoradionecrosis
Increased numbers of osteoclasts expressing cysteine proteinase cathepsin K in patients with infected osteoradionecrosis and bisphosphonate-associated osteonecrosis-a paradoxical observation?
Osteosarcoma
A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors.
Otitis Media
Recurrence of antigen-induced otitis media by thiol compound.
Ovarian Neoplasms
Determination of cysteine peptidases-like activity and their inhibitors in the serum of patients with ovarian cancer treated by conventional chemotherapy and vitamin E.
Expression of high molecular weight cysteine proteinase inhibitor in ovarian cancer tissues: regulation of cathepsin B expression by placental CPI.
Puncta intended: connecting the dots between autophagy and cell stress networks.
The activities and subcellular localization of cathepsin B and cysteine proteinase inhibitors in human ovarian carcinoma.
Pancreatic Neoplasms
Inhibition of cysteine peptidase activity in ascitic fluid in pancreatic cancer patients.
Over-expression of cysteine proteinase inhibitor cystatin 6 promotes pancreatic cancer growth.
Pancreatitis
Pancreatic lysosomal thiol proteinases and inhibitors in acute pancreatitis induced in rats.
Paragonimiasis
Enzyme-linked immunosorbent assay using cysteine proteinase antigens for immunodiagnosis of human paragonimiasis.
Parasitic Diseases
A new, sensitive fluorogenic substrate for papain based on the sequence of the cystatin inhibitory site.
Anti-Fas2 IgM antibodies in Fasciola hepatica infected patients with positive IgG serology.
Cruzipain: An Update on its Potential as Chemotherapy Target against the Human Pathogen Trypanosoma cruzi.
Cysteine proteinase inhibitors as therapy for parasitic diseases: advances in inhibitor design.
Parkinson Disease
Cystatin C prevents degeneration of rat nigral dopaminergic neurons: in vitro and in vivo studies.
Periodontal Diseases
Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis.
Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease.
Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system.
Structural characterization of argingipain, a novel arginine-specific cysteine proteinase as a major periodontal pathogenic factor from Porphyromonas gingivalis.
[Gingipains as the determinants of periodontopathogenicity]
Periodontitis
Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues.
Modification of cystatin C activity by bacterial proteinases and neutrophil elastase in periodontitis.
Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling.
Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis.
[The proteinase inhibitors of mixed saliva in periodontitis]
Perivascular Epithelioid Cell Neoplasms
Cathepsin K is Superior to HMB45 for the Diagnosis of Pulmonary Lymphangioleiomyomatosis.
Pheochromocytoma
Cysteine proteinase inhibitors and ras gene products share the same biological activities including transforming activity toward NIH3T3 mouse fibroblasts and the differentiation-inducing activity toward PC12 rat pheochromocytoma cells.
Pleural Effusion
A latent form of cathepsin B in pleural effusions. I. Characterization of the enzyme in breast cancer patients.
Pneumocystis Infections
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Porcine Reproductive and Respiratory Syndrome
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction.
Targeted mutations in a highly conserved motif of the nsp1? protein impair the interferon antagonizing activity of porcine reproductive and respiratory syndrome virus.
The Nonstructural Protein 1 Papain-Like Cysteine Protease Was Necessary for Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1 to Inhibit Interferon-? Induction.
Prostatic Hyperplasia
Expression of acid cysteine proteinase inhibitor (ACPI) in the normal human prostate, benign prostatic hyperplasia and adenocarcinoma.
Prostatic Neoplasms
Decreased activity of cathepsins L + B and decreased invasive ability of PC3 prostate cancer cells.
Increased cell density decreases cysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines.
Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C.
Protein Deficiency
[Lysosomes in cellular activity. Physiology and pathology]
Proteinuria
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis.
The cysteine proteinase inhibitor, E-64, reduces proteinuria in an experimental model of glomerulonephritis.
Purpura, Thrombotic Thrombocytopenic
A cathepsin-like cysteine proteinase proaggregating activity in thrombotic thrombocytopenic purpura.
Further characterization of platelet-aggregating cysteine proteinase activity in thrombotic thrombocytopenic purpura.
Isolation and characterization of cysteine proteinase in thrombotic thrombocytopenic purpura.
Pycnodysostosis
Cathepsin K: a unique collagenolytic cysteine peptidase.
Renal Insufficiency
Serum cysteine proteinase inhibitors with special reference to kidney failure.
Rheumatic Diseases
[Cysteine proteinase inhibitors in the synovial fluid in rheumatic diseases]
Rhinitis, Allergic
Epitope mapping and structural analysis of the anti-Der p 1 monoclonal antibody: insight into therapeutic potential.
Rubella
Calcium-dependent association of calmodulin with the rubella virus nonstructural protease domain.
Characterization of the rubella virus nonstructural protease domain and its cleavage site.
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Mutational analysis of the rubella virus nonstructural polyprotein and its cleavage products in virus replication and RNA synthesis.
The rubella virus nonstructural protease requires divalent cations for activity and functions in trans.
Sarcoma
Enzymatic detection systems for non-isotopic in situ hybridization using biotinylated cDNA probes.
Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma.
Sarcoma 180
Cysteine proteinase inhibitor in the ascitic fluid of sarcoma 180 tumor-bearing mice is a low molecular weight kininogen. Partial NH2- and COOH-terminal sequences and susceptibility to various glandular kallikreins.
Thiol proteinase inhibitor in the ascitic fluid of sarcoma 180 tumor-bearing mice.
Schistosomiasis
Diagnosis of early pre-patent schistosomiasis by cystatin capture enzyme-linked immunosorbent assay.
Evaluation of Schistosoma haematobium 27-29 kDa antigen for immunodiagnosis of schistosomiasis haematobium.
Severe Acute Respiratory Syndrome
Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase.
Severe Combined Immunodeficiency
Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice.
Shock, Septic
Enzymatically active cathepsin B dissociating from its inhibitor complexes is elevated in blood plasma of patients with septic shock and some malignant tumors.
Streptococcal pyrogenic exotoxin A, streptolysin O, exoenzymes, serotype and biotype profiles of Streptococcus pyogenes isolates from patients with toxic shock syndrome and other severe infections.
Small Cell Lung Carcinoma
Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell lines.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Squamous Cell Carcinoma of Head and Neck
Cathepsin K modulates invasion, migration and adhesion of oral squamous cell carcinomas in vitro.
Starvation
Initial cell-type choice in a simple eukaryote: cell-autonomous or morphogen-gradient dependent?
Virulence of Entamoeba histolytica is upregulated by short-term glucose starvation.
Status Epilepticus
Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse.
Stomach Neoplasms
MiRNA-3978 regulates peritoneal gastric cancer metastasis by targeting legumain.
Streptococcal Infections
Is the nephritogenic antigen in post-streptococcal glomerulonephritis pyrogenic exotoxin B (SPE B) or GAPDH?
Thyroid Neoplasms
Cysteine proteinase inhibitor in cultured human medullary thyroid carcinoma cells.
Tongue Neoplasms
[Potential use of cysteine endopeptidase inhibitors in radiodiagnostics of laryngeal and tongue neoplasms]
Trichinellosis
Cystatin capture-dot-enzyme-linked immunosorbent assay for immunodiagnosis and assessment of cure of experimental trichinellosis in mice.
Trichomonas Infections
The effect of iron on Trichomonas vaginalis TvCP2, a cysteine proteinase found in vaginal secretions of trichomoniasis patients.
Triple Negative Breast Neoplasms
Puncta intended: connecting the dots between autophagy and cell stress networks.
Trypanosomiasis, African
Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target.
Vaccinia
Development of an in vitro cleavage assay system to examine vaccinia virus I7L cysteine proteinase activity.
Molecular dissection of the vaccinia virus I7L core protein proteinase.
Virus Diseases
Adenovirus endopeptidase and its role in virus infection.
Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection.
Purification and characterization of cysteine proteinase from a baculovirus gene.
Vitamin E Deficiency
Enhancement of testicular cysteine proteinase inhibitor level in vitamin E-deficient rats.
Yellow Fever
Mosquito cathepsin B-like protease involved in embryonic degradation of vitellin is produced as a latent extraovarian precursor.