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Reference on EC 3.4.22.30 - Caricain

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Polgar, L.
Isolation of highly active papaya peptidases A and B from commercial chymopapain
Biochim. Biophys. Acta
658
262-269
1981
Carica papaya
Manually annotated by BRENDA team
Sumner, I.G.; Harris, G.W.; Taylor, M.A.J.; Pickersgill, R.W.; Owen, A.J.; Goodenough, P.W.
Factors effecting the thermostability of cysteine proteinases from Carica papaya
Eur. J. Biochem.
214
129-134
1993
Carica papaya
Manually annotated by BRENDA team
Goodenough, P.E.; Owen, J.
Chromatographic and electrophoretic analyses of papaya proteinases
Phytochemistry
26
75-79
1987
Carica papaya
-
Manually annotated by BRENDA team
Brocklehurst, K.; Baines, B.S.; Salih, E.; Hatzoulis, C.
Chymopapain S is chymopapain A
Biochem. J.
221
553-554
1984
Carica papaya
Manually annotated by BRENDA team
Polgar, L.
Problems of classification of papaya latex proteinases
Biochem. J.
221
555-556
1984
Carica papaya
Manually annotated by BRENDA team
Brocklehurst, K.; Salih, E.; McKee, R.; Smith, H.
Fresh non-fruit latex of Carica papaya contains papain, multiple forms of chymopapain A and papaya proteinase omega
Biochem. J.
228
525-527
1985
Carica papaya
Manually annotated by BRENDA team
Barrett, A.J.; Buttle, D.J.
Names and numbers of papaya proteinases
Biochem. J.
228
527
1985
Carica papaya
Manually annotated by BRENDA team
Dubois, T.; Kleinschmidt, T.; Schnek, A.G.; Looze, Y.; Braunitzer, G.
The thiol proteinases from the latex of Carica papaya L. II. The primary structure of proteinase omega
Biol. Chem. Hoppe-Seyler
369
741-754
1988
Carica papaya
Manually annotated by BRENDA team
Zucker, S.; Buttle, D.J.; Nicklin, M.J.H.; Barrett, A.J.
The proteolytic activities of chymopapain, papain, and papaya proteinase III
Biochim. Biophys. Acta
828
196-204
1985
Carica papaya
Manually annotated by BRENDA team
Baines, B.S.; Brocklehurst, K.
Characterization of papaya peptidase A as a cysteine proteinase of Carica papaya L. with active-centre properties that differ from those of papain by using 2,2-dipyridyl disulphide and 4-chloro-7-nitrobenzofurazan as reactivity probes. Use of two-protonic-state electrophiles in the identification of catalytic-site thiol groups
Biochem. J.
205
205-211
1982
Carica papaya
Manually annotated by BRENDA team
Robinson, G.W.
Isolation and characterization of papaya peptidase A from commercial chymopapain
Biochemistry
14
3695-3700
1975
Carica papaya
Manually annotated by BRENDA team
Goodenough, P.W.; Owen, J.
Papaya proteinases separated by novel means have been used to generate monoclonal antibodies
Biochem. Soc. Trans.
15
264-265
1987
Carica papaya
-
Manually annotated by BRENDA team
Baines, B.S.; Brocklehurst, K.; Carey, P.R.; Jarvis, M.; Salih, E.; Storer, A.C.
Chymopapain A. Purification and investigation by covalent chromatography and characterization by two-protonic-state reactivity-probe kinetics, steady-state kinetics and resonance Raman spectroscopy of some dithioacyl derivatives
Biochem. J.
233
119-129
1986
Carica papaya
Manually annotated by BRENDA team
Schack, P.; Kaarsholm, N.C.
Absence in papaya peptidase A catalyzed hydrolyses of a pKa apprx. 4 present in papain-catalyzed hydrolyses
Biochemistry
23
631-635
1984
Carica papaya
-
Manually annotated by BRENDA team
Schack, P.; Kaarsholm, N.C.
Subsite differences between the active centres of papaya peptidase A and papain as revealed by affinity chromatography. Purification of papaya peptidase A by ionic-strength-dependent affinity adsorption on an immobilized peptide inhibitor of papain
Biochem. J.
219
727-733
1984
Carica papaya
Manually annotated by BRENDA team
Sumner, I.G.; Vaughan, A.; Eisenthal, R.; Pickersgill, R.W.; Owen, A.J.; Goodenough, P.W.
Kinetic analysis of papaya proteinase omega
Biochim. Biophys. Acta
1164
243-251
1993
Carica papaya
Manually annotated by BRENDA team
Topham, C.M.; Salih, E.; Frazao, C.; Kowlessur, D.; Overington, J.P.; Thomas, M.; Brocklehurst, S.M.; Patel, M.; Thomas, E.W.; Brocklehurst, K.
Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by two-hydronic-state reactivity probe kinetics and kinetics of catalysis
Biochem. J.
280
79-92
1991
Carica papaya
Manually annotated by BRENDA team
Kaarsholm, N.C.; Schack, P.
Characterization of papaya peptidase A as an enzyme of extreme basicity
Acta Chem. Scand. B
37
607-611
1983
Carica papaya
Manually annotated by BRENDA team
Noble, M.A.; Gul, S.; Verma, C.S.; Brocklehurst, K.
Ionization characteristics and chemical influences of aspartic acid residue 158 of papain and caricain determined by structure-related kinetic and computational techniques: multiple electrostatic modulators of active-centre chemistry
Biochem. J.
351
723-733
2000
Carica papaya
Manually annotated by BRENDA team
Reid, J.D.; Hussain, S.; Sreedharan, S.K.; Bailey, T.S.F.; Pinitglang, S.; Thomas, E.W.; Verma, C.S.; Brocklehurst, K.
Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulations
Biochem. J.
357
343-352
2001
Carica papaya
Manually annotated by BRENDA team
Pinitglang, S.; Patel, M.; Noble, M.; Sreedharan, S.K.; Verma, C.; Thomas, E.W.; Brocklehurst, K.
Effects of the quality of the P2-S2 hydrophobic contacts on the catalytic activities of papain, caricain and ficin and their generation by electrostatic switches
Biochem. Soc. Trans.
25
88S
1997
Carica papaya
Manually annotated by BRENDA team
Noble, M.; Abramson, D.; Verma, C.; Brocklehurst, K.
Evidence that the carboxy groups of Asp158 in papain and caricain have abnormally low pKa values and thus do not contribute the key ionizations with pKa 4 that generate catalytic competence
Biochem. Soc. Trans.
25
90S
1997
Carica papaya
Manually annotated by BRENDA team
Khan, A.; Connerton, I.F.; Cummings, N.J.; Hussain, S.; Noble, M.A.; Taylor, M.A.J.; Thomas, E.W.; Verma, C.; Brocklehurst, K.
The kinetically influential ionizations of caricain D158N revealed by using 4,4'-dipyrimidyl disulfide as a reactivity probe
Biochem. Soc. Trans.
26
S172
1998
Carica papaya
Manually annotated by BRENDA team
Lopez-Arenas, L.; Solis-Mendiola, S.; Hernandez-Arana, A.
Estimating the degree of expansion in the transition state for protein unfolding: analysis of the pH dependence of the rate constant for caricain denaturation
Biochemistry
38
15936-15943
1999
Carica papaya
Manually annotated by BRENDA team
Ikeuchi, Y.; Katerelos, N.A.; Goodenough, P.W.
The enhancing of a cysteine proteinase activity at acidic pH by protein engineering, the role of glutamic 50 in the enzyme mechanism of caricain
FEBS Lett.
437
91-96
1998
Carica papaya (P10056), Carica papaya
Manually annotated by BRENDA team
Azarkan, M.; El Moussaoui, A.; van Wuytswinkel, D.; Dehon, G.; Looze, Y.
Fractionation and purification of the enzymes stored in the latex of Carica papaya
J. Chromatogr. B
790
229-238
2003
Carica papaya
Manually annotated by BRENDA team
Huet, J.; Looze, Y.; Bartik, K.; Raussens, V.; Wintjens, R.; Boussard, P.
Structural characterization of the papaya cysteine proteinases at low pH
Biochem. Biophys. Res. Commun.
341
620-626
2006
Carica papaya
Manually annotated by BRENDA team
Azarkan, M.; Dibiani, R.; Baulard, C.; Baeyens-Volant, D.
Effects of mechanical wounding on Carica papaya cysteine endopeptidases accumulation and activity
Int. J. Biol. Macromol.
38
216-224
2006
Carica papaya
Manually annotated by BRENDA team
Liu, W.; Ye, W.; Wang, Z.; Chao, H.; Lian, J.
Preparation and characterization of a truncated caricain lacking 41 residues from the N-terminal
Protein J.
24
243-251
2005
Carica papaya
Manually annotated by BRENDA team
Cornell, H.J.; Doherty, W.; Stelmasiak, T.
Papaya latex enzymes capable of detoxification of gliadin
Amino Acids
38
155-165
2009
Carica papaya, Carica papaya (P10056)
Manually annotated by BRENDA team
Cornell, H.; Stelmasiak, T.
Caricain: A basis for enzyme therapy for coeliac disease
South Afr. J. Sci.
107
75-79
2011
Carica papaya
-
Manually annotated by BRENDA team
Buddrick, O.; Cornell, H.J.; Small, D.M.
Reduction of toxic gliadin content of wholegrain bread by the enzyme caricain
Food Chem.
170
343-347
2015
Carica papaya (P10056), Carica papaya
Manually annotated by BRENDA team
Liu, J.; Sharma, A.; Niewiara, M.; Singh, R.; Ming, R.; Yu, Q.
Papain-like cysteine proteases in Carica papaya lineage-specific gene duplication and expansion
BMC Genomics
19
26
2018
Carica papaya (P10056), Carica papaya
Manually annotated by BRENDA team