Reference on EC 3.4.22.16 - cathepsin H
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lenney, J.F.; Liao, J.R.; Sugg, S.L.; Gopalakrishnan, V.; Wong, H.C.H.; Ouye, K.H.; Chan, P.W.H.
Low molecular weight inhibitors of cathepsins B, H and T in human serum, synovial fluid and CSF
Biochem. Biophys. Res. Commun.
108
1581-1587
1982
Homo sapiens
Barrett, A.J.; Kirschke, H.
Cathepsin B, Cathepsin H, and cathepsin L
Methods Enzymol.
80
535-561
1981
Homo sapiens, Rattus norvegicus
Lenney, J.F.; Tolan, J.R.; Sugai, W.J.; Lee, A.G.
Thermostable endogenous inhibitors of cathepsins B and H
Eur. J. Biochem.
101
153-161
1979
Homo sapiens, Paramecium caudatum, Rattus norvegicus, Sus scrofa, Tetrahymena pyriformis
Taniguchi, T.; Mizuochi, T.; Towatari, T.; Katunuma, N.; Kobata, A.
Structural studies on the carbohydrate moieties of rat liver cathepsins B and H
J. Biochem.
97
973-976
1985
Rattus norvegicus
Fuchs, R.; Machleidt, W.; Gassen, H.G.
Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H
Biol. Chem. Hoppe-Seyler
369
469-475
1988
Homo sapiens
Popovic, T.; Brzin, J.; Kos, J.; Lenarcic, B.; Machleidt, W.; Ritonja, A.; Hanada, K.; Turk, V.
A new purification procedure of human kidney cathepsin H, its properties ans kinetic data
Biol. Chem. Hoppe-Seyler
369
175-183
1988
Homo sapiens
-
Hara, K.; Kominami, E.; Katunuma, N.
Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages
FEBS Lett.
231
229-231
1988
Rattus norvegicus
Ritonja, A.; Popovic, T.; Kotnik, M.; Machleidt, W.; Turk, V.
Amino acid sequences of the human kidney cathepsins H and L
FEBS Lett.
228
341-345
1988
Homo sapiens
Nishimura, Y.; Amano, J.; Sato, H.; Tsuji, H.; Kato, K.
Biosynthesis of lysosomal cathepsins B and H in cultures rat hepatocytes
Arch. Biochem. Biophys.
262
159-170
1988
Rattus norvegicus
Ishidoh, K.; Imajoh, S.; Emori, Y.; Ohno, S.; Kawasaki, H.; Minami, Y.; Kominami, E.; Katunuma, N.; Suzuki, K.
Molecular cloning and sequencing of cDNA for rat cathepsin H
FEBS Lett.
226
33-37
1987
Rattus norvegicus
Brmme, D.; Bescherer, K.; Kirschke, H.; Fittkau, S.
Enzyme-substrate interactions in the hydrolysis of peptides by cathepsins B and H from rat liver
Biochem. J.
245
381-385
1987
Rattus norvegicus
Rogers, J.C.; Dean, D.; Heck, G.R.
Aleurain: a barley thiol protease closely related to mammalian cathepsin H
Proc. Natl. Acad. Sci. USA
82
6512-6516
1985
Hordeum vulgare
Kominami, E.; Tsukahara, T.; Bando, Y.; Katunuma, N.
Distribution of cathepsins B and H in rat tissues and peripheral blood cells
J. Biochem.
98
87-93
1985
Rattus norvegicus
Willenbrock, F.; Brocklehurst, K.
Preparation of cathepsins B and H by covalent chromatography and characterization of their catalytic sites by reaction with a thiol-specific two-protonic-state reactivity probe
Biochem. J.
85
511-519
1985
Bos taurus
-
Takahashi, T.; Dehdarani, A.H.; Schmidt, P.G.; Tang, J.
Cathepsins B and H from porcine spleen
J. Biol. Chem.
259
9874-9882
1984
Sus scrofa
Takio, K.; Towatari, T.; Katunuma, N.; Teller, D.C.; Titani, K.
Homology of amino acid sequences of rat liver cathepsins B and H with that of papain
Proc. Natl. Acad. Sci. USA
80
3666-3670
1983
Rattus norvegicus
Bergmeyer, H.U.ed
Cathepsin B, cathepsin H, and cathepsin L
Methods Enzym. Anal. (3rd. ed. )
5
195-210
1984
Homo sapiens, Rattus norvegicus
-
Schwartz, W.N.; Barrett, A.J.
Human cathepsin H
Biochem. J.
191
487-497
1980
Homo sapiens, Rattus norvegicus
Singh, H.; Kalnitsky, G.
Separation of a new alpha-N-benzoylarginine-beta-naphthylamide hydrolase from cathepsin B1
J. Biol. Chem.
253
4319-4326
1978
Oryctolagus cuniculus
Sivaparvathi, M.; Sawaya, R.; Gokaslan, Z.L.; Chintala, K.S.; Rao, J.S.
Expression and the role of cathepsin H in human glioma progression and invasion
Cancer Lett.
104
121-126
1996
Homo sapiens, Rattus norvegicus
Aranishi, F.; Hara, K.; Osatomi, K.; Ishihara, T.
Substrate specificity of carp Cyprinus carpio cathepsin H with methylcoumarylamide substrates
Comp. Biochem. Physiol. B
116B
203-208
1997
Cyprinus carpio
Guncar, G.; Podobnik, M.; Pungercar, J.; Strukelj, B.; Turk, V.; Turk, D.
Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function
Structure
6
51-61
1998
Homo sapiens, Sus scrofa
Rothe, M.; Doth, J.
Studies on the aminopeptidase activity of rat cathepsin H
Eur. J. Biochem.
210
759-764
1992
Rattus norvegicus
Raghav, N.; Kamboj, R.C.; Parnami, S.; Singh, H.
Physico-chemical properties of brain cathepsin H
Indian J. Biochem. Biophys.
32
279-285
1995
Bos taurus
Aranishi, F.; Hara, K.; Ishinara, T.
Purification and characterization of cathepsin H from hepatopancreas of carp Cyprinus carpio
Comp. Biochem. Physiol. B
102B
499-505
1992
Cyprinus carpio
Yamamoto, K.; Kamata, O.; Kato, Y.
Separation and properties of three forms of cathepsin H-like cysteine proteinase from rat spleen
J. Biochem.
95
477-484
1984
Rattus norvegicus
Kominami, E.; Katunuma, N.
Immunological studies on cathepsins B and H from rat liver
J. Biochem.
91
67-71
1982
Rattus norvegicus
Kamphuis, I.G.; Drenth, J.; Baker, E.N.
Thiol proteases: comparative studies on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain
J. Mol. Biol.
182
317-329
1985
Homo sapiens
Vasiljeva, O.; Dolinar, M.; Turk, V.; Turk, B.
Recombinant human cathepsin H lacking the mini chain is an endopeptidase
Biochemistry
42
13522-13528
2003
Homo sapiens, Sus scrofa
Dodt, J.; Reichwein, J.
Human cathepsin H: deletion of the mini-chain switches substrate specificity from aminopeptidase to endopeptidase
Biol. Chem.
384
1327-1332
2003
Homo sapiens
Matsuishi, M.; Saito, G.; Okitani, A.; Kato, H.
Purification and some properties of cathepsin H from rabbit skeletal muscle
Int. J. Biochem. Cell Biol.
35
474-485
2003
Oryctolagus cuniculus
Jenko, S.; Dolenc, I.; Guncar, G.; Dobersek, A.; Podobnik, M.; Turk, D.
Crystal structure of stefin A in complex with cathepsin H: N-terminal residues of inhibitors can adapt to the active sites of endo- and exopeptidases
J. Mol. Biol.
326
875-885
2003
Sus scrofa
Brguljan, P.M.; Turk, V.; Nina, C.; Brzin, J.; Krizaj, I.; Popovic, T.
Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme
Peptides
24
1977-1984
2003
Homo sapiens
Froehlich, E.; Moehrle, M.; Klessen, C.
Cathepsins in basal cell carcinomas: activity, immunoreactivity and mRNA staining of cathepsins B, D, H and L. [Erratum to document cited in CA141:021292]
Arch. Dermatol. Res.
296
94
2004
Homo sapiens
-
Bratkovic, T.; Lunder, M.; Popovic, T.; Kreft, S.; Turk, B.; Strukelj, B.; Urleb, U.
Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K
Biochem. Biophys. Res. Commun.
332
897-903
2005
Homo sapiens
Horn, M.; Doleckova-Maresova, L.; Rulisek, L.; Masa, M.; Vasiljeva, O.; Turk, B.; Gan-Erdene, T.; Baudys, M.; Mares, M.
Activation processing of cathepsin H impairs recognition by its propeptide
Biol. Chem.
386
941-947
2005
Homo sapiens (P09668)
Chornaya, V.; Lyannaya, O.
Some physicochemical properties of cathepsin H from human meningioma
Exp. Oncol.
26
278-281
2004
Homo sapiens
Ueno, T.; Linder, S.; Na, C.L.; Rice, W.R.; Johansson, J.; Weaver, T.E.
Processing of pulmonary surfactant protein B by napsin and cathepsin H
J. Biol. Chem.
279
16178-16184
2004
Homo sapiens
Serveau-Avesque, C.; Ferrer-Di Martino, M.; Herve-Grepinet, V.; Hazouard, E.; Gauthier, F.; Diot, E.; Lalmanach, G.
Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids
Biol. Cell.
98
15-22
2006
Homo sapiens
Torikai, H.; Akatsuka, Y.; Miyazaki, M.; Tsujimura, A.; Yatabe, Y.; Kawase, T.; Nakao, Y.; Tsujimura, K.; Motoyoshi, K.; Morishima, Y.; Kodera, Y.; Kuzushima, K.; Takahashi, T.
The human cathepsin H gene encodes two novel minor histocompatibility antigen epitopes restricted by HLA-A*3101 and -A*3303
Br. J. Haematol.
134
406-416
2006
Homo sapiens (P09668), Homo sapiens
Woischnik, M.; Bauer, A.; Aboutaam, R.; Pamir, A.; Stanzel, F.; de Blic, J.; Griese, M.
Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis
Eur. Respir. J.
31
1197-1204
2008
Homo sapiens (P09668), Homo sapiens
Lue, J.; Qian, J.; Keppler, D.; Cardoso, W.V.
Cathepsin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis
J. Biol. Chem.
282
22176-22184
2007
Mus musculus
Nagaraj, N.S.; Santhanam, K.
Effect of frozen temperature and storage time on calpains, cathepsins (B, B + L, H and D) and their endogenous inhibitors in goat muscles
J. Food Biochem.
30
155-173
2006
Capra aegagrus
Yeh, H.Y.; Klesius, P.H.
Channel catfish, Ictalurus punctatus, cysteine proteinases: cloning, characterisation and expression of cathepsin H and L
Fish Shellfish Immunol.
26
332-338
2009
Ictalurus punctatus (B5LVX3), Ictalurus punctatus
Sethadavit, M.; Meemon, K.; Jardim, A.; Spithill, T.W.; Sobhon, P.
Identification, expression and immunolocalization of cathepsin B3, a stage-specific antigen expressed by juvenile Fasciola gigantica
Acta Trop.
112
164-173
2009
Fasciola gigantica (Q86MW6), Fasciola gigantica
Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
Substrate optimization for monitoring cathepsin C activity in live cells
Bioorg. Med. Chem.
17
1064-1070
2009
Homo sapiens
D'Angelo, M.E.; Bird, P.I.; Peters, C.; Reinheckel, T.; Trapani, J.A.; Sutton, V.R.
Cathepsin H is an additional convertase of pro-granzyme B
J. Biol. Chem.
285
20514-20519
2010
Mus musculus
Buehling, F.; Kouadio, M.; Chwieralski, C.E.; Kern, U.; Hohlfeld, J.M.; Klemm, N.; Friedrichs, N.; Roth, W.; Deussing, J.M.; Peters, C.; Reinheckel, T.
Gene targeting of the cysteine peptidase cathepsin H impairs lung surfactant in mice
PLoS ONE
6
e26247
2011
Mus musculus
Raghav, N.; Garg, S.
N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H
Bioorg. Chem.
57
43-50
2014
Capra hircus
Singh, M.; Raghav, N.
2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H
Bioorg. Chem.
59
12-22
2015
Capra hircus
Raghav, N.; Singh, M.
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
Eur. J. Med. Chem.
77
231-242
2014
Capra hircus
Jevnikar, Z.; Rojnik, M.; Jamnik, P.; Doljak, B.; Fonovic, U.P.; Kos, J.
Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells
J. Biol. Chem.
288
2201-2209
2013
Homo sapiens
Lu, W.D.; Funkelstein, L.; Toneff, T.; Reinheckel, T.; Peters, C.; Hook, V.
Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters
J. Neurochem.
122
512-522
2012
Bos taurus, Mus musculus
Raghav, N.; Singh, M.
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
Bioorg. Med. Chem.
22
4233-4245
2014
Capra hircus
Garg, S.; Raghav, N.
2,5-Diaryloxadiazoles and their precursors as novel inhibitors of cathepsins B, H and L
Bioorg. Chem.
67
64-74
2016
Capra hircus (A0A060INS8)
Raghav, N.; Kaur, R.
Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L
Int. J. Biol. Macromol.
80
710-724
2015
Capra hircus (A0A060INS8)
Naeem, A.S.; Tommasi, C.; Cole, C.; Brown, S.J.; Zhu, Y.; Way, B.; Willis Owen, S.A.; Moffatt, M.; Cookson, W.O.; Harper, J.I.; Di, W.L.; Brown, S.J.; Reinheckel, T.; O'Shaughnessy, R.F.
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
J. Allergy Clin. Immunol.
139
1228-1241
2017
Rattus norvegicus (P00786), Homo sapiens (P09668), Homo sapiens, Mus musculus (P49935), Mus musculus, Mus musculus C57BL/6J (P49935)
Raghav, N.; Kaur, R.
A comparative account of sar studies of semicarbazones and thiosemicarbazones on cathepsins H and L
Med. Chem. Res.
26
1723-1734
2017
Capra hircus (A0A060INS8)
-
Hao, Y.; Purtha, W.; Cortesio, C.; Rui, H.; Gu, Y.; Chen, H.; Sickmier, E.A.; Manzanillo, P.; Huang, X.
Crystal structures of human procathepsin H
PLoS ONE
13
e0200374
2018
Homo sapiens (P09668), Homo sapiens
Garg, S.; Raghav, N.
Inhibitory potential of some chalcones on cathepsins B, H and L
RSC Adv.
5
72937-72949
2015
Capra hircus (A0A060INS8)
-
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