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lung adenocarcinoma cell line
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all K10 present in ovarian cancer ascites fluids are in the uncomplexed, zymogen form and have no detectable enzymatic activity
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-
no mRNA expression, enzyme barely detectable
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-
mRNA expression, enzyme detectable
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-
-
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-
downregulation
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lower KLK10 levels in pleomorphic adenoma suggests aberrant expression in a tumour that develops primarily from myoepithelial cells
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gene expression
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significantly upregulated
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immunohistochemic expression analysis, overview
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the enzyme is up-regulated in colorectal cancer
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-
-
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-
-
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-
-
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Barrett esophagus with and without dysplasia
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early stage
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-
-
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barely detectable gene expression
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no mRNA expression, enzyme barely detectable
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-
-
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hypermethylated KLK10 is frequent in hepatocellular carcinoma
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-
-
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-
-
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-
-
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-
no mRNA expression, enzyme barely detectable
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-
-
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-
-
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-
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normal strain 76N and oncogenically transforming strain 76R-30
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KLK10 expression in cancerous and noncancerous canine mammary tissues, overview
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KLK10 expression in cancerous and noncancerous canine mammary tissues, overview
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-
mRNA expression, enzyme detectable
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-
no mRNA expression, enzyme barely detectable
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-
mRNA expression, enzyme detectable
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KLK10 is significantly downregulated as compared to non-cancer samples. CpG island hypermethylation of KLK10 is detected in 46.2% of non-small cell lung cancer tissues
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kallikreins 10 is abundantly expressed in human oral squamous cell carcinoma and may be implicated in malignant progression
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downregulation due to hypermethylation of exon 3
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significantly upregulated
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coexpression of KLK10 and KLK6 plays an unfavourable role in pancreatic ductal adenocarcinoma
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-
mRNA expression, enzyme detectable
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immunohistochemic enzyme expression analysis in various surgically removed corticotroph adenoma subtypes: lowest enzyme expression in the silent corticotroph subtypes 1 and 2, compared with nontumorous human adenohypophysial corticotrophs, high enzyme expression in endocrinologically active subtypes, ACTH-secreting adenomas, corticotroph carcinomas, Crooke cell adenomas, Crooke cell carcinomas
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-
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endocrinologically active adrenocorticotropic hormone (ACTH)-producing pituitary tumors and the silent subtypes are immunopositve for kallikrein 10. Immunoexpression of kallikrein 10 in the ACTH-secreting tumors as well as in the Crooke cell tumors is significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of nontumorous pituitaries
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gene expression
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-
decreased expression compared to normal cell
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-
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from malignant tumours, adenoid cystic carcinoma and mucoepidermoid carcinoma
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-
-
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-
downregulation
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gene expression
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-
increased mRNA expression compared to normal cells
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-
-
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mRNA expression, enzyme detectable
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gene expression
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barely detectable gene expression
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-
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-
increased mRNA expression compared to noncancer cells
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-
-
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expression in normal cells, but no expression in breast cancer cells
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KLK10 is not methylated in normal breast tissues and fibroadenomas while it is in 5 of 10 breast tumors and in 1 of 10 matching normal tissues
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-
-
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downregulation due to hypermethylation of exon 3
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KLK10 is not methylated in normal breast tissues and fibroadenomas while it is in 5 of 10 breast tumors and in 1 of 10 matching normal tissues
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-
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immunohistochemic expression analysis, overview
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-
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significantly upregulated
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-
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gene expression
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high expression
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gene expression
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-
gene expression
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-
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significantly upregulated
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downregulation
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no mRNA expression, enzyme barely detectable
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additional information
the enzyme shows a wide tissue distribution, and its expression level does not vary between healthy and cancer tissue
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additional information
-
the enzyme shows a wide tissue distribution, and its expression level does not vary between healthy and cancer tissue
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additional information
gene expression is almost lost in breast cancer cell lines
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additional information
no expression in fibroblasts, peripheral blood leukocytes, brain, placenta, lung, liver, skeletal muscle, and kidney
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additional information
significantly increased enzyme expression in dysplastic lesions compared with metaplasia but not between dysplastic lesions and invasive cancers, immunohistochemic analysis, overview
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additional information
-
significantly increased enzyme expression in dysplastic lesions compared with metaplasia but not between dysplastic lesions and invasive cancers, immunohistochemic analysis, overview
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Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (O43240)
brenda
El Moujahed, A.; Brillard-Bourdet, M.; Juliano, M.A.; Moreau, T.; Chagas, J.R.; Gutman, N.; Prado, E.S.; Gauthier, F.
Kininogen-derived fluorogenic substrates for investigating the vasoactive properties of rat kallikreins. Identification of a T-kinin-releasing rat kallikrein
Eur. J. Biochem.
247
652-658
1997
Rattus norvegicus
brenda
Liu, X.L.; Wazer, D.E.; Watanabe, K.; Band, V.
Identification of a novel serine protease-like gene, the expression of which is down-regulated during breast cancer progression
Cancer Res.
56
3371-3379
1996
Homo sapiens (O43240)
brenda
Santin, A.D.; Diamandis, E.P.; Bellone, S.; Marizzoni, M.; Bandiera, E.; Palmieri, M.; Papasakelariou, C.; Katsaros, D.; Burnett, A.; Pecorelli, S.
Overexpression of kallikrein 10 (hK10) in uterine serous papillary carcinomas
Am. J. Obstet. Gynecol.
194
1296-1302
2006
Homo sapiens
brenda
Zhang, Y.; Bhat, I.; Zeng, M.; Jayal, G.; Wazer, D.E.; Band, H.; Band, V.
Human kallikrein 10, a predictive marker for breast cancer
Biol. Chem.
387
715-721
2006
Homo sapiens
brenda
Planque, C.; Ainciburu, M.; Heuze-Vourch, N.; Regina, S.; de Monte, M.; Courty, Y.
Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues
Biol. Chem.
387
783-788
2006
Homo sapiens
brenda
Yousef, G.M.; White, N.M.; Michael, I.P.; Cho, J.C.; Robb, J.D.; Kurlender, L.; Khan, S.; Diamandis, E.P.
Identification of new splice variants and differential expression of the human kallikrein 10 gene, a candidate cancer biomarker
Tumour Biol.
26
227-235
2005
Homo sapiens (O43240), Homo sapiens
brenda
Sidiropoulos, M.; Pampalakis, G.; Sotiropoulou, G.; Katsaros, D.; Diamandis, E.P.
Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers
Tumour Biol.
26
324-336
2005
Homo sapiens
brenda
Petraki, C.D.; Gregorakis, A.K.; Vaslamatzis, M.M.; Papanastasiou, P.A.; Yousef, G.M.; Levesque, M.A.; Diamandis, E.P.
Prognostic Implications of the Immunohistochemical Expression of Human Kallikreins 5, 6, 10 and 11 in Renal Cell Carcinoma
Tumour Biol.
27
1-7
2006
Homo sapiens
brenda
Zeng, M.; Zhang, Y.; Bhat, I.; Wazer, D.E.; Band, H.; Band, V.
The human kallikrein 10 promoter contains a functional retinoid response element
Biol. Chem.
387
741-747
2006
Homo sapiens
brenda
Kulasingam, V.; Diamandis, E.P.
Glucocorticoid receptor-mediated expression of kallikrein 10 in human breast cancer cell lines
Biol. Chem.
388
1113-1119
2007
Homo sapiens
brenda
Ewan King, L.; Li, X.; Cheikh Saad Bouh, K.; Pedneault, M.; Chu, C.W.
Human kallikrein 10 ELISA development and validation in breast cancer sera
Clin. Biochem.
40
1057-1062
2007
Homo sapiens
brenda
Feng, B.; Xu, W.B.; Zheng, M.H.; Ma, J.J.; Cai, Q.; Zhang, Y.; Ji, J.; Lu, A.G.; Qu, Y.; Li, J.W.; Wang, M.L.; Hu, W.G.; Liu, B.Y.; Zhu, Z.G.
Clinical significance of human kallikrein 10 gene expression in colorectal cancer and gastric cancer
J. Gastroenterol. Hepatol.
21
1596-1603
2006
Homo sapiens
brenda
Luo, L.; Soosaipillai, A.; Grass, L.; Diamandis, E.P.
Characterization of human kallikreins 6 and 10 in ascites fluid from ovarian cancer patients
Tumour Biol.
27
227-234
2006
Homo sapiens (O43240)
brenda
Kioulafa, M.; Kaklamanis, L.; Stathopoulos, E.; Mavroudis, D.; Georgoulias, V.; Lianidou, E.S.
Kallikrein 10 (KLK10) methylation as a novel prognostic biomarker in early breast cancer
Ann. Oncol.
20
1020-1025
2009
Homo sapiens (O43240), Homo sapiens
brenda
Rueckert, F.; Hennig, M.; Petraki, C.D.; Wehrum, D.; Distler, M.; Denz, A.; Schroeder, M.; Dawelbait, G.; Kalthoff, H.; Saeger, H.D.; Diamandis, E.P.; Pilarsky, C.; Gruetzmann, R.
Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma
Br. J. Cancer
99
1484-1492
2008
Homo sapiens (O43240)
brenda
Pettus, J.R.; Johnson, J.J.; Shi, Z.; Davis, J.W.; Koblinski, J.; Ghosh, S.; Liu, Y.; Ravosa, M.J.; Frazier, S.; Stack, M.S.
Multiple kallikrein (KLK 5, 7, 8, and 10) expression in squamous cell carcinoma of the oral cavity
Histol. Histopathol.
24
197-207
2009
Homo sapiens (O43240)
brenda
Zhang, Y.; Song, H.; Miao, Y.; Wang, R.; Chen, L.
Frequent transcriptional inactivation of Kallikrein 10 gene by CpG island hypermethylation in non-small cell lung cancer
Cancer Sci.
101
934-940
2010
Homo sapiens (Q6ICR6), Homo sapiens
brenda
Lu, C.Y.; Hsieh, S.Y.; Lu, Y.J.; Wu, C.S.; Chen, L.C.; Lo, S.J.; Wu, C.T.; Chou, M.Y.; Huang, T.H.; Chang, Y.S.
Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma
Genes Chromosomes Cancer
48
1057-1068
2009
Homo sapiens
brenda
Angelopoulou, K.; Karagiannis, G.S.
The canine kallikrein-related peptidases 9 and 10: structural characterization and expression in mammary cancer
Mamm. Genome
20
758-767
2010
Canis lupus familiaris (D2IJU0), Canis lupus familiaris
brenda
Talieri, M.; Alexopoulou, D.K.; Scorilas, A.; Kypraios, D.; Arnogiannaki, N.; Devetzi, M.; Patsavela, M.; Xynopoulos, D.
Expression analysis and clinical evaluation of kallikrein-related peptidase 10 (KLK10) in colorectal cancer
Tumour Biol.
32
737-744
2011
Homo sapiens
brenda
Di Meo, A.; Rotondo, F.; Kovacs, K.; Cusimano, M.D.; Syro, L.V.; Di Ieva, A.; Diamandis, E.P.; Yousef, G.M.
Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study
Appl. Immunohistochem. Mol. Morphol.
23
433-437
2014
Homo sapiens (O43240), Homo sapiens
brenda
Grin, A.; Samaan, S.; Tripathi, M.; Rotondo, F.; Kovacs, K.; Bassily, M.N.; Yousef, G.M.
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma
Hum. Pathol.
46
541-548
2015
Homo sapiens (O43240), Homo sapiens
brenda
Darling, M.R.; Hashem, N.N.; Zhang, I.; Mohamed, A.B.; Fung, K.; Kwan, K.; Mara, T.W.; Daley, T.D.; Diamandis, E.P.
Kallikrein-related peptidase 10 expression in salivary gland tissues and tumours
Int. J. Biol. Markers
27
e381-e388
2013
Homo sapiens (O43240)
brenda
Petraki, C.; Youssef, Y.M.; Dubinski, W.; Lichner, Z.; Scorilas, A.; Pasic, M.D.; Komborozos, V.; Khalil, B.; Streutker, C.; Diamandis, E.P.; Yousef, G.M.
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer
Tumour Biol.
33
1209-1214
2012
Homo sapiens (O43240), Homo sapiens
brenda
Geng, X.; Liu, Y.; Dreyer, T.; Bronger, H.; Drecoll, E.; Magdolen, V.; Dorn, J.
Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients
Am. J. Cancer Res.
8
1856-1864
2018
Homo sapiens (O43240), Homo sapiens
brenda
Di Meo, A.; Rotondo, F.; Kovacs, K.; Cusimano, M.; Syro, L.; Di Ieva, A.; Diamandis, E.; Yousef, G.
Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas an immunohistochemical study
Appl. Immunohistochem. Mol. Morphol.
23
433-437
2015
Homo sapiens (O43240), Homo sapiens
brenda
Shimura, T.; Ebi, M.; Yamada, T.; Yamada, T.; Katano, T.; Nojiri, Y.; Iwasaki, H.; Nomura, S.; Hayashi, N.; Mori, Y.; Kataoka, H.; Moses, M.A.; Joh, T.
Urinary kallikrein 10 predicts the incurability of gastric cancer
Oncotarget
8
29247-29257
2017
Homo sapiens (O43240), Homo sapiens
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