Disease on EC 3.4.21.B25 - PACE4 proprotein convertase
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Adenocarcinoma
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Adenocarcinoma
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Anemia
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Anthrax
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.
Breast Neoplasms
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
Breast Neoplasms
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Breast Neoplasms
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells.
Carcinogenesis
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Carcinogenesis
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
Carcinogenesis
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Carcinogenesis
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Carcinoma
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Carcinoma
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
Carcinoma
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4.
Carcinoma
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Carcinoma
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Carcinoma
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Carcinoma
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.
Carcinoma, Non-Small-Cell Lung
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Carcinoma, Squamous Cell
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Carcinoma, Squamous Cell
Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).
Carcinoma, Squamous Cell
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Choriocarcinoma
The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2.
Diphtheria
Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.
Endometrial Neoplasms
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Hemochromatosis
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Hyperthyroidism
PACE4: a subtilisin-like endoprotease prevalent in the anterior pituitary and regulated by thyroid status.
Lung Neoplasms
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Lymphatic Metastasis
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Melanoma
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Nasopharyngeal Carcinoma
PACE4 Expression is a Novel Independent Prognostic Factor in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).
Neoplasm Metastasis
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Neoplasm Metastasis
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Neoplasm Metastasis
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Neoplasm Metastasis
PACE4 Expression is a Novel Independent Prognostic Factor in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Neoplasm Metastasis
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Neoplasm Metastasis
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Neoplasms
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Neoplasms
Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor.
Neoplasms
Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase.
Neoplasms
Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6).
Neoplasms
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug.
Neoplasms
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Neoplasms
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability.
Neoplasms
Expression of paired basic amino acid-cleaving enzyme 4 (PACE4) correlated with prognosis in non-small cell lung cancer (NSCLC) patients.
Neoplasms
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Neoplasms
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Neoplasms
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Neoplasms
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.
Neoplasms
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Neoplasms
Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4.
Neoplasms
miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
Neoplasms
Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity.
Neoplasms
PACE4 expression in mouse basal keratinocytes results in basement membrane disruption and acceleration of tumor progression.
Neoplasms
PACE4 Expression is a Novel Independent Prognostic Factor in Nasopharyngeal Carcinoma.
Neoplasms
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction increased apoptosis and impaired neovascularisation.
Neoplasms
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Neoplasms
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Neoplasms
PACE4 regulates proliferation, migration and invasion in human breast cancer MDA-MB-231 cells.
Neoplasms
PACE4-based molecular targeting of prostate cancer using an engineered ??Cu-radiolabeled peptide inhibitor.
Neoplasms
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Neoplasms
Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.
Neoplasms
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Neoplasms
Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Neoplasms
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Neoplasms
The proprotein convertases furin and PACE4 play a significant role in tumor progression.
Neoplasms
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.
Neoplasms
Upregulation of PACE4 in Prostate Cancer is not dependent on E2F Transcription Factors.
Nervous System Neoplasms
Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Neuroblastoma
Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1.
Osteoarthritis
A functional polymorphism in the paired basic amino acid-cleaving enzyme 4 gene confers osteoarthritis risk in a population of Eastern China.
Osteoarthritis
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Osteoarthritis, Knee
A role for PACE4 in osteoarthritis pain: evidence from human genetic association and null mutant phenotype.
Ovarian Neoplasms
Epigenetic regulation of proprotein convertase PACE4 gene expression in human ovarian cancer cells.
Ovarian Neoplasms
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Pancreatic Neoplasms
PACE4 regulates apoptosis in human pancreatic cancer Panc?1 cells via the mitochondrial signaling pathway.
Prostatic Neoplasms
Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor.
Prostatic Neoplasms
Enhanced anti-tumor activity of the Multi-Leu peptide PACE4 inhibitor transformed into an albumin-bound tumor-targeting prodrug.
Prostatic Neoplasms
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Prostatic Neoplasms
Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue.
Prostatic Neoplasms
Increasing C-Terminal Hydrophobicity Improves the Cell Permeability and Antiproliferative Activity of PACE4 Inhibitors against Prostate Cancer Cell Lines.
Prostatic Neoplasms
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells.
Prostatic Neoplasms
Macrocyclization of a potent PACE4 inhibitor: Benefits and limitations.
Prostatic Neoplasms
miR-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.
Prostatic Neoplasms
Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity.
Prostatic Neoplasms
Novel Insights into Structure-Activity Relationships of N-Terminally Modified PACE4 Inhibitors.
Prostatic Neoplasms
PACE4 inhibitors and their peptidomimetic analogs block prostate cancer tumor progression through quiescence induction increased apoptosis and impaired neovascularisation.
Prostatic Neoplasms
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Prostatic Neoplasms
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Prostatic Neoplasms
PACE4-based molecular targeting of prostate cancer using an engineered ??Cu-radiolabeled peptide inhibitor.
Prostatic Neoplasms
Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.
Prostatic Neoplasms
Proprotein convertase inhibition: Paralyzing the cell's master switches.
Prostatic Neoplasms
Rational Design of a Highly Potent and Selective Peptide Inhibitor of PACE4 by Salt Bridge Interaction with D160 at Position P3.
Prostatic Neoplasms
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Prostatic Neoplasms
Upregulation of PACE4 in Prostate Cancer is not dependent on E2F Transcription Factors.
Skin Neoplasms
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Spinal Cord Injuries
Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion.
Vaccinia
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.
Vaccinia
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
Vaccinia
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways.
Vaccinia
Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases.
Vaccinia
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Vaccinia
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4.
Vaccinia
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Vaccinia
Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.
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