Reference on EC 3.4.21.93 - Proprotein convertase 1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
Homo sapiens, Mus musculus
Jean, F.; Basak, A.; DiMaio, J.; Seidah, N.G.; Lazure, C.
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor
Biochem. J.
307
689-695
1995
Homo sapiens
Smeekens, S.P.; Avruch, A.S.; LaMendola, J.; Chan, S.J.; Steiner, D.F.
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
Proc. Natl. Acad. Sci. USA
88
340-344
1991
Mus musculus
Seidah, N.G.; Chretien, M.
Pro-protein convertases of subtilisin/kexin family
Methods Enzymol.
244
175-188
1994
Homo sapiens, Mus musculus
Li, Q.L.; Jansen, E.; Brent, G.A.; Friedman, T.C.
Regulation of prohormone convertase 1 (PC1) by thyroid hormone
Am. J. Physiol. Endocrinol. Metab.
280
E160-170
2001
Homo sapiens, Rattus norvegicus
Basak, A.; Lazure, C.
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes
Biochem. J.
373
231-239
2003
Mus musculus
Jutras, I.; Seidah, N.G.; Reudelhuber, T.L.; Brechler, V.
Two activation states of the prohormone convertase PC1 in the secretory pathway
J. Biol. Chem.
272
15184-15188
1997
Mus musculus
Boudreault, A.; Gauthier, D.; Lazure, C.
Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin
J. Biol. Chem.
273
31574-31580
1998
Mus musculus
Viale, A.; Ortola, C.; Hervieu, G.; Furuta, M.; Barbero, P.; Steiner, D.F.; Seidah, N.G.; Nahon, J.L.
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals
J. Biol. Chem.
274
6536-6545
1999
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Jutras, I.; Seidah, N.G.; Reudelhuber, T.L.
A predicted alpha-helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway
J. Biol. Chem.
275
40337-40343
2000
Mus musculus, Rattus norvegicus
Basak, A.; Koch, P.; Dupelle, M.; Fricker, L.D.; Devi, L.A.; Chretien, M.; Seidah, N.G.
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
J. Biol. Chem.
276
32720-32728
2001
Mus musculus
Li, Q.L.; Jansen, E.; Friedman, T.C.
Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines
Mol. Cell. Endocrinol.
158
143-152
1999
Mus musculus, Rattus norvegicus
Muller, L.; Lindberg, I.
The cell biology of the prohormone convertases PC1 and PC2
Prog. Nucleic Acid Res. Mol. Biol.
63
69-108
1999
Drosophila sp. (in: flies), Mus musculus, no activity in Caenorhabditis elegans, Rattus norvegicus, no activity in Lymnaea stagnalis
Boudreault, A.; Gauthier, D.; Rondeau, N.; Savaria, D.; Seidah, N.G.; Chretien, M.; Lazure, C.
Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells
Protein Expr. Purif.
14
353-366
1998
Mus musculus
Bonic, A.; Mackin, R.B.
Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment
Protein Expr. Purif.
28
15-24
2003
Homo sapiens
Stettler, H.; Suri, G.; Spiess, M.
Proprotein convertase PC3 is not a transmembrane protein
Biochemistry
44
5339-5345
2005
Homo sapiens
Tzimas, G.N.; Chevet, E.; Jenna, S.; Nguyen, D.T.; Khatib, A.M.; Marcus, V.; Zhang, Y.; Chretien, M.; Seidah, N.; Metrakos, P.
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases
BMC Cancer
5
149
2005
Homo sapiens
Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide
Diabetes
53
141-148
2004
Mus musculus
Posner, S.F.; Vaslet, C.A.; Jurofcik, M.; Lee, A.; Seidah, N.G.; Nillni, E.A.
Stepwise posttranslational processing of pro-growth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1
Endocrine
23
199-213
2004
Mus musculus
Dey, A.; Norrbom, C.; Zhu, X.; Stein, J.; Zhang, C.; Ueda, K.; Steiner, D.F.
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
Endocrinology
145
1961-1971
2004
Mus musculus
Dey, A.; Lipkind, G.M.; Rouille, Y.; Norrbom, C.; Stein, J.; Zhang, C.; Carroll, R.; Steiner, D.F.
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon
Endocrinology
146
713-727
2005
Mus musculus
Salvas, A.; Benjannet, S.; Reudelhuber, T.L.; Chretien, M.; Seidah, N.G.
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi
FEBS Lett.
579
5621-5625
2005
Mus musculus
Mulcahy, L.R.; Vaslet, C.A.; Nillni, E.A.
Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides
J. Biol. Chem.
280
39818-39826
2005
Rattus norvegicus
Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
J. Biol. Chem.
281
11050-11057
2006
Mus musculus
Rabah, N.; Gauthier, D.; Wilkes, B.C.; Gauthier, D.J.; Lazure, C.
Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme
J. Biol. Chem.
281
7556-7567
2006
Mus musculus (P63239)
Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone
J. Clin. Invest.
114
357-369
2004
Rattus norvegicus
Lee, S.N.; Prodhomme, E.; Lindberg, I.
Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS
J. Endocrinol.
182
353-364
2004
Mus musculus
Henrich, S.; Lindberg, I.; Bode, W.; Than, M.E.
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
J. Mol. Biol.
345
211-227
2004
Homo sapiens
Shen, X.; Li, Q.L.; Brent, G.A.; Friedman, T.C.
Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements
J. Mol. Endocrinol.
33
21-33
2004
Rattus norvegicus
Tagen, M.B.; Beinfeld, M.C.
Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
Peptides
26
2530-2535
2005
Mus musculus
Rabah, N.; Gauthier, D.J.; Gauthier, D.; Lazure, C.
Improved PC1/3 production through recombinant expression in insect cells and larvae
Protein Expr. Purif.
37
377-384
2004
Mus musculus
Rabah, N.; Gauthier, D.; Dikeakos, J.D.; Reudelhuber, T.L.; Lazure, C.
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
FEBS J.
274
3482-3491
2007
Mus musculus
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
Espinosa, V.P.; Ferrini, M.; Shen, X.; Lutfy, K.; Nillni, E.A.; Friedman, T.C.
Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism
Am. J. Physiol. Endocrinol. Metab.
292
E175-E186
2007
Rattus norvegicus
Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
Diabetes
56
2744-2752
2007
Mus musculus
Lloyd, D.J.; Bohan, S.; Gekakis, N.
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
Hum. Mol. Genet.
15
1884-1893
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Farooqi, I.S.; Volders, K.; Stanhope, R.; Heuschkel, R.; White, A.; Lank, E.; Keogh, J.; ORahilly, S.; Creemers, J.W.
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
J. Clin. Endocrinol. Metab.
92
3369-3373
2007
Homo sapiens
Lou, H.; Smith, A.M.; Coates, L.C.; Cawley, N.X.; Loh, Y.P.; Birch, N.P.
The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway
Mol. Cell. Endocrinol.
267
17-25
2007
Mus musculus, Rattus norvegicus
Marandi, M.; Mowla, S.J.; Tavallaei, M.; Yaghoobi, M.M.; Jafarnejad, S.M.
Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs)
Neurosci. Lett.
420
198-203
2007
Rattus norvegicus
Rehfeld, J.F.; Zhu, X.; Norrbom, C.; Bundgaard, J.R.; Johnsen, A.H.; Nielsen, J.E.; Vikesaa, J.; Stein, J.; Dey, A.; Steiner, D.F.; Friis-Hansen, L.
Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17
Biochem. J.
415
35-43
2008
Mus musculus
Lankat-Buttgereit, B.; Mueller, S.; Schmidt, H.; Parhofer, K.G.; Gress, T.M.; Goeke, R.
Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line
Biol. Cell
100
703-715
2008
Homo sapiens
Garruti, G.; Cotecchia, S.; Giampetruzzi, F.; Giorgino, F.; Giorgino, R.
Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome
J. Gastrointestin. Liver Dis.
17
193-198
2008
Homo sapiens
Fox, D.L.; Good, D.J.
Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3
Mol. Endocrinol.
22
1438-1448
2008
Mus musculus
Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction
Neuroscience
156
788-799
2008
Homo sapiens, Rattus norvegicus
Zhou, J.; Cai, Z.H.
Molecular cloning and characterization of prohormone convertase 1 gene in abalone (Haliotis diversicolor supertexta)
Comp. Biochem. Physiol. B
155
331-339
2010
Haliotis diversicolor supertexta
Sun, J.; Zhang, C.; Fang, X.; Lei, C.; Lan, X.; Chen, H.
Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits
Biochem. Genet.
48
779-788
2010
Capra hircus (D8V3M2)
Ozawa, A.; Peinado, J.R.; Lindberg, I.
Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis
Endocrinology
151
4437-4445
2010
Mus musculus
Kilimnik, G.; Kim, A.; Steiner, D.; Friedman, T.; Hara, M.
Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of beta-cell regeneration
Islets
2
149-155
2010
Mus musculus
Zhan, S.; Zhou, A.; Lan, J.; Yang, T.
Proprotein convertase 1 mRNA and protein expression in ischemic rat cortex after reperfusion
Neural Regen. Res.
6
295-299
2011
Rattus norvegicus
-
Hiramoto, K.; Yamate, Y.; Kobayashi, H.; Ishii, M.; Sato, E.F.; Inoue, M.
Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone
Clin. Exp. Dermatol.
38
71-76
2013
Mus musculus (P63239)
Ozawa, S.; Katsuta, H.; Suzuki, K.; Takahashi, K.; Tanaka, T.; Sumitani, Y.; Nishida, S.; Yoshimoto, K.; Ishida, H.
Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic beta-cells of type 2 diabetic patients
Endocr. J.
61
607-614
2014
Homo sapiens (P29120)
Blanco, E.H.; Peinado, J.R.; Martin, M.G.; Lindberg, I.
Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph
Endocrinology
155
3434-3447
2014
Homo sapiens (P29120)
Gagnon, H.; Refaie, S.; Gagnon, S.; Desjardins, R.; Salzet, M.; Day, R.
Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion
PLoS ONE
8
e61557
2013
Rattus norvegicus
Wilschanski, M.; Abbasi, M.; Blanco, E.; Lindberg, I.; Yourshaw, M.; Zangen, D.; Berger, I.; Shteyer, E.; Pappo, O.; Bar-Oz, B.; Martin, M.G.; Elpeleg, O.
A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity
PLoS ONE
9
e108878
2014
Homo sapiens (P29120)
Elferich, J.; Williamson, D.M.; David, L.L.; Shinde, U.
Determination of histidine pKa values in the propeptides of furin and proprotein convertase 1/3 using histidine hydrogen-deuterium exchange mass spectrometry
Anal. Chem.
87
7909-7917
2015
Homo sapiens (P29120)
Righi, A.; Faustini-Fustini, M.; Morandi, L.; Monti, V.; Asioli, S.; Mazzatenta, D.; Bacci, A.; Foschini, M.P.
The changing faces of corticotroph cell adenomas the role of prohormone convertase 1/3
Endocrine
56
286-297
2017
Homo sapiens (P29120)
Li, J.; Mao, Z.; Huang, J.; Xia, J.
PICK1 is essential for insulin production and the maintenance of glucose homeostasis
Mol. Biol. Cell
29
587-596
2018
Mus musculus
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