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Disease on EC 3.4.21.92 - Endopeptidase Clp

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Anemia, Hypochromic
Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus.
ClpC1, an ATP-dependent Clp protease in plastids, is involved in iron homeostasis in Arabidopsis leaves.
Inactivation of the clpC1 gene encoding a chloroplast Hsp100 molecular chaperone causes growth retardation, leaf chlorosis, lower photosynthetic activity, and a specific reduction in photosystem content.
Blindness
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development.
Dehydration
A nuclear gene, erd1, encoding a chloroplast-targeted Clp protease regulatory subunit homolog is not only induced by water stress but also developmentally up-regulated during senescence in Arabidopsis thaliana.
Hypersensitivity
Communication of ClpXP protease hypersensitivity to bacteriophage Mu repressor isoforms.
Infections
Alteration of protein homeostasis mediates the interaction of Pseudomonas aeruginosa with Staphylococcus aureus.
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
Development of Antibiotics That Dysregulate the Neisserial ClpP Protease.
Development of high throughput screening methods for inhibitors of ClpC1P1P2 from Mycobacteria tuberculosis.
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Dual RNA-seq in Streptococcus pneumoniae Infection Reveals Compartmentalized Neutrophil Responses in Lung and Pleural Space.
Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival.
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne.
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection.
Proteomic comparison of Mycobacterium avium subspecies paratuberculosis grown in vitro and isolated from clinical cases of ovine paratuberculosis.
Recent advances in Clp protease modulation to address virulence, resistance and persistence of MRSA infection.
Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system.
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
The ClpC ATPase of Listeria monocytogenes is a general stress protein required for virulence and promoting early bacterial escape from the phagosome of macrophages.
The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections.
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development.
The development of small-molecule modulators for ClpP protease activity.
The Stringent Stress Response Controls Proteases and Global Regulators under Optimal Growth Conditions in Pseudomonas aeruginosa.
Two isoforms of Clp peptidase in Pseudomonas aeruginosa control distinct aspects of cellular physiology.
Infertility
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
Leprosy
Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins.
Leukemia, Myeloid, Acute
The role of mitochondrial proteases in leukemic cells and leukemic stem cells.
Liver Cirrhosis, Biliary
Antibodies against homologous microbial caseinolytic proteases P characterise primary biliary cirrhosis.
Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.
Antibodies to Clp protease in primary biliary cirrhosis: possible role of a mimicking T-cell epitope.
Liver Diseases
Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis.
Malaria
A cyanobacterial serine protease of Plasmodium falciparum is targeted to the apicoplast and plays an important role in its growth and development.
A novel class of Plasmodial ClpP protease inhibitors as potential antimalarial agents.
Bayesian analysis of new and old malaria parasite DNA sequence data demonstrates the need for more phylogenetic signal to clarify the descent of Plasmodium falciparum.
Malaria parasite sequences from chimpanzee support the co-speciation hypothesis for the origin of virulent human malaria (Plasmodium falciparum).
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites.
Malaria, Avian
Plasmodium (Haemamoeba) cathemerium gene sequences for phylogenetic analysis of malaria parasites.
Neoplasms
Contribution of the Clp Protease to Bacterial Survival and Mitochondrial Homoeostasis.
Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
Mechanisms of imipridones in targeting mitochondrial metabolism in cancer cells.
Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer.
Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers.
The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice.
Neuroblastoma
Streptococcus pneumoniae ClpP protease induces apoptosis via caspase-independent pathway in human neuroblastoma cells: cytoplasmic relocalization of p53.
Parasitic Diseases
A chemical inhibitor of heat shock protein 78 (HSP78) from Leishmania donovani represents a potential antileishmanial drug candidate.
Persistent Infection
Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha.
Plant Diseases
Antagonistic Regulation by CPN60A and CLPC1 of TRXL1 that Regulates MDH Activity Leading to Plant Disease Resistance and Thermotolerance.
Pneumococcal Infections
Caseinolytic protease: a protein vaccine which could elicit serotype-independent protection against invasive pneumococcal infection.
Enhanced protection against pneumococcal infection elicited by immunization with the combination of PspA, PspC, and ClpP.
Immunization with a combination of three pneumococcal proteins confers additive and broad protection against Streptococcus pneumoniae Infections in Mice.
Mucosal immunization with caseinolytic protease X elicited cross-protective immunity against pneumococcal infection in mice.
Mucosal immunization with purified ClpP could elicit protective efficacy against pneumococcal pneumonia and sepsis in mice.
Pneumonia
The ClpXP Protease Contributes to Staphylococcus aureus Pneumonia.
Pneumonia, Staphylococcal
The ClpXP Protease Contributes to Staphylococcus aureus Pneumonia.
Sepsis
Streptococcus pneumoniae: proteomics of surface proteins for vaccine development.
Sexually Transmitted Diseases
The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development.
The functional ClpXP protease of Chlamydia trachomatis requires distinct clpP genes from separate genetic loci.
Staphylococcal Infections
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Starvation
Chlorosis during nitrogen starvation is altered by carbon dioxide and temperature status and is mediated by the ClpP1 protease in Synechococcus elongatus.
Global role for ClpP-containing proteases in stationary-phase adaptation of Escherichia coli.
Inter- and intramolecular regulation of protein depupylation in Mycobacterium smegmatis.
Mycobacterium smegmatis MSMEG_0129 is a nutrition-associated regulator that interacts with CarD and ClpP2.
Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease.
Role of Clp protease subunits in degradation of carbon starvation proteins in Escherichia coli.
Role of the response regulator RssB in sigma recognition and initiation of sigma proteolysis in Escherichia coli.
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.
Tuberculosis
A ClpP protein model as tuberculosis target for screening marine compounds.
Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.
An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1.
Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase.
Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2.
Bortezomib Warhead-Switch Confers Dual Activity against Mycobacterial Caseinolytic Protease and Proteasome and Selectivity against Human Proteasome.
Characterization of a Clp protease gene regulator and the reaeration response in Mycobacterium tuberculosis.
Cleavage specificity of Mycobacterium tuberculosis ClpP1P2 protease and identification of novel peptide substrates and boronate inhibitors with anti-bacterial activity.
Cloning and characterization of Clp protease proteolytic subunit 2 and its implication in clinical diagnosis of tuberculosis.
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.
Delving Into the Functional Meaning of Phenotypic Variation in Mycobacterial Persistence: Who Benefits the Most From Programmed Death of Individual Cells?
Design, synthesis and biological evaluation of novel pyrrole derivatives as potential ClpP1P2 inhibitor against Mycobacterium tuberculosis.
Detection of Novel Gene Mutations Associated with Pyrazinamide Resistance in Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates in Southern China.
Gift from Nature: Cyclomarin?A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.
In Vivo-Selected Pyrazinoic Acid-Resistant Mycobacterium tuberculosis Strains Harbor Missense Mutations in the Aspartate Decarboxylase PanD and the Unfoldase ClpC1.
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1.
Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis.
Mutation analysis of the interactions between Mycobacterium tuberculosis caseinolytic protease C1 (ClpC1) and ecumicin.
Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis.
Mycobacterial Caseinolytic Protease Gene Regulator ClgR Is a Substrate of Caseinolytic Protease.
Mycobacterium tuberculosis ClpC1 N-Terminal Domain Is Dispensable for Adaptor Protein-Dependent Allosteric Regulation.
Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function.
Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection.
Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly.
Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis.
Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus.
Species variation in ATP-dependent protein degradation: protease profiles differ between mycobacteria and protease functions differ between Mycobacterium smegmatis and Escherichia coli.
Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase.
Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria.
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.
The antibiotic cyclomarin blocks arginine-phosphate-induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis.
The C-terminus of ClpC1 of Mycobacterium tuberculosis is crucial for its oligomerization and function.
The Clp Chaperones and Proteases of the Human Malaria Parasite Plasmodium falciparum.
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo.
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.
The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini.
Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities.
Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target.
[Prediction and Analysis of Epitopes in clpP2 of Mycobacterium tuberculosis].