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Reference on EC 3.4.21.91 - Flavivirin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chambers, T.J.; Hahn, C.S.; Galler, R.; Rice, C.M.
Flavivirus genome organization, expression, and replication
Annu. Rev. Microbiol.
44
649-688
1990
Dengue virus, Flavivirus sp., Yellow fever virus
Manually annotated by BRENDA team
Cah, A.; Falgout, B.; Lai, C.J.
Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease
J. Virol.
66
1535-1542
1992
Dengue virus
Manually annotated by BRENDA team
Lin, C.; Amberg, S.M.; Chambers, T.J.; Rice, C.M.
Cleavage at a novel site in the NS4A region by the yellow fever virus NS2B-3 proteinase is a prerequisite for processing at the downstream 4A/4B signalase site
J. Virol.
67
2327-2335
1993
Yellow fever virus
Manually annotated by BRENDA team
Chambers, T.J.; Nestorowicz, A.; Rice, C.M.
Mutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replication
J. Virol.
69
1600-1605
1995
Yellow fever virus
Manually annotated by BRENDA team
Murthy, H.M.K.; Judge, K.; DeLucas, L.; Clum, S.; Padmanabhan, R.
Crystallization, characterization and measurement of MAD data on crystals of dengue virus NS3 serine protease complexed with mung-bean Bowman-Birk inhibitor
Acta Crystallogr. Sect. D
55
1370-1372
1999
Dengue virus
-
Manually annotated by BRENDA team
Krishna Murthy, H.M.; Clum, S.; Padmanabhan, R.
Dengue virus NS3 serine protease. Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects
J. Biol. Chem.
274
5573-5580
1999
Dengue virus
Manually annotated by BRENDA team
Droll, D.A.; Krishna Murthy, H.M.; Chambers, T.J.
Yellow fever virus NS2B-NS3 protease: charged-to-alanine mutagenesis and deletion analysis define regions important for protease complex formation and function
Virology
275
335-347
2000
Yellow fever virus
Manually annotated by BRENDA team
D'Arcy, A.; Chaillet, M.; Schiering, N.; Villard, F.; Lim, S.P.; Lefeuvre, P.; Erbel, P.
Purification and crystallization of dengue and West Nile virus NS2B-NS3 complexes
Acta Crystallogr. Sect. F
62
157-162
2006
Dengue virus, West Nile virus
Manually annotated by BRENDA team
Li, J.; Lim, S.P.; Beer, D.; Patel, V.; Wen, D.; Tumanut, C.; Tully, D.C.; Williams, J.A.; Jiricek, J.; Priestle, J.P.; Harris, J.L.; Vasudevan, S.G.
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries
J. Biol. Chem.
280
28766-28774
2005
Dengue virus
Manually annotated by BRENDA team
Niyomrattanakit, P.; Winoyanuwattikun, P.; Chanprapaph, S.; Angsuthanasombat, C.; Panyim, S.; Katzenmeier, G.
Identification of residues in the dengue virus type 2 NS2B cofactor that are critical for NS3 protease activation
J. Virol.
78
13708-13716
2004
Dengue virus type 2
Manually annotated by BRENDA team
Ramanathan, M.P.; Chambers, J.A.; Pankhong, P.; Chattergoon, M.; Attatippaholkun, W.; Dang, K.; Shah, N.; Weiner, D.B.
Host cell killing by the West Nile Virus NS2B-NS3 proteolytic complex: NS3 alone is sufficient to recruit caspase-8-based apoptotic pathway
Virology
345
56-72
2006
West Nile virus
Manually annotated by BRENDA team
Lin, C.W.; Lin, K.H.; Lyu, P.C.; Chen, W.J.
Japanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper
Virus Res.
116
106-113
2006
Japanese encephalitis virus
Manually annotated by BRENDA team
Chanprapaph, S.; Saparpakorn, P.; Sangma, C.; Niyomrattanakit, P.; Hannongbua, S.; Angsuthanasombat, C.; Katzenmeier, G.
Competitive inhibition of the dengue virus NS3 serine protease by synthetic peptides representing polyprotein cleavage sites
Biochem. Biophys. Res. Commun.
330
1237-1246
2005
Dengue virus
Manually annotated by BRENDA team
Gouvea, I.E.; Izidoro, M.A.; Judice, W.A.; Cezari, M.H.; Caliendo, G.; Santagada, V.; dos Santos, C.N.; Queiroz, M.H.; Juliano, M.A.; Young, P.R.; Fairlie, D.P.; Juliano, L.
Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates
Arch. Biochem. Biophys.
457
187-196
2007
Dengue virus
Manually annotated by BRENDA team
Johnston, P.A.; Phillips, J.; Shun, T.Y.; Shinde, S.; Lazo, J.S.; Huryn, D.M.; Myers, M.C.; Ratnikov, B.I.; Smith, J.W.; Su, Y.; Dahl, R.; Cosford, N.D.; Shiryaev, S.A.; Strongin, A.Y.
HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus
Assay Drug Dev. Technol.
5
737-750
2007
West Nile virus
Manually annotated by BRENDA team
Shiryaev, S.A.; Kozlov, I.A.; Ratnikov, B.I.; Smith, J.W.; Lebl, M.; Strongin, A.Y.
Cleavage preference distinguishes the two-component NS2B-NS3 serine proteinases of Dengue and West Nile viruses
Biochem. J.
401
743-752
2007
West Nile virus, Dengue virus type 2, Dengue virus type 2 16681, West Nile virus NY99
Manually annotated by BRENDA team
Othman, R.; Wahab, H.A.; Yusof, R.; Rahman, N.A.
Analysis of secondary structure predictions of dengue virus type 2 NS2B/NS3 against crystal structure to evaluate the predictive power of the in silico methods
In Silico Biol.
7
215-224
2007
Dengue virus type 2
Manually annotated by BRENDA team
Bera, A.K.; Kuhn, R.J.; Smith, J.L.
Functional characterization of cis and trans activity of the Flavivirus NS2B-NS3 protease
J. Biol. Chem.
282
12883-12892
2007
Japanese encephalitis virus, West Nile virus, Yellow fever virus, Dengue virus type 2, Dengue virus type 4, West Nile virus NY99
Manually annotated by BRENDA team
Pastorino, B.A.; Peyrefitte, C.N.; Grandadam, M.; Thill, M.C.; Tolou, H.J.; Bessaud, M.
Mutagenesis analysis of the NS2B determinants of the Alkhurma virus NS2B-NS3 protease activation
J. Gen. Virol.
87
3279-3283
2006
Alkhumra hemorrhagic fever virus
Manually annotated by BRENDA team
Loehr, K.; Knox, J.E.; Phong, W.Y.; Ma, N.L.; Yin, Z.; Sampath, A.; Patel, S.J.; Wang, W.L.; Chan, W.L.; Rao, K.R.; Wang, G.; Vasudevan, S.G.; Keller, T.H.; Lim, S.P.
Yellow fever virus NS3 protease: peptide-inhibition studies
J. Gen. Virol.
88
2223-2227
2007
Yellow fever virus
Manually annotated by BRENDA team
Radichev, I.; Shiryaev, S.A.; Aleshin, A.E.; Ratnikov, B.I.; Smith, J.W.; Liddington, R.C.; Strongin, A.Y.
Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase
J. Gen. Virol.
89
636-641
2008
West Nile virus (P06935), West Nile virus, West Nile virus NY99 (P06935)
Manually annotated by BRENDA team
Tedbury, P.R.; Harris, M.
Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities
J. Mol. Biol.
366
1652-1660
2007
Hepacivirus C
Manually annotated by BRENDA team
Shiryaev, S.A.; Ratnikov, B.I.; Aleshin, A.E.; Kozlov, I.A.; Nelson, N.A.; Lebl, M.; Smith, J.W.; Liddington, R.C.; Strongin, A.Y.
Switching the substrate specificity of the two-component NS2B-NS3 flavivirus proteinase by structure-based mutagenesis
J. Virol.
81
4501-4509
2007
Dengue virus, West Nile virus
Manually annotated by BRENDA team
Luo, D.; Xu, T.; Hunke, C.; Grueber, G.; Vasudevan, S.G.; Lescar, J.
Crystal structure of the NS3 protease-helicase from dengue virus
J. Virol.
82
173-183
2008
Dengue virus type 4
Manually annotated by BRENDA team
Lorenz, I.C.; Marcotrigiano, J.; Dentzer, T.G.; Rice, C.M.
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
Nature
442
831-835
2006
Hepacivirus C
Manually annotated by BRENDA team
Shiryaev, S.A.; Aleshin, A.E.; Ratnikov, B.I.; Smith, J.W.; Liddington, R.C.; Strongin, A.Y.
Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region
Protein Expr. Purif.
52
334-339
2007
West Nile virus
Manually annotated by BRENDA team
Bessaud, M.; Pastorino, B.A.; Peyrefitte, C.N.; Rolland, D.; Grandadam, M.; Tolou, H.J.
Functional characterization of the NS2B/NS3 protease complex from seven viruses belonging to different groups inside the genus Flavivirus
Virus Res.
120
79-90
2006
Yellow fever virus, Zika virus, Saint Louis encephalitis virus, Bussuquara virus, Langat virus (P29837), Dengue virus type 3 (Q6YMS4), dengue virus type I (Q91NH1), Yellow fever virus Asibi, Dengue virus type 3 Sri Lanka/1266/2000 (Q6YMS4), dengue virus type I D1/H/IMTSSA/98/606 (Q91NH1), Langat virus TP21 (P29837), Zika virus Ar-D-41644, Saint Louis encephalitis virus MSI-7
Manually annotated by BRENDA team
Niyomrattanakit, P.; Yahorava, S.; Mutule, I.; Mutulis, F.; Petrovska, R.; Prusis, P.; Katzenmeier, G.; Wikberg, J.E.
Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides
Biochem. J.
397
203-211
2006
Dengue virus type 2
Manually annotated by BRENDA team
Kiat, T.S.; Pippen, R.; Yusof, R.; Ibrahim, H.; Khalid, N.; Rahman, N.A.
Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease
Bioorg. Med. Chem. Lett.
16
3337-3340
2006
Dengue virus type 2
Manually annotated by BRENDA team
Yin, Z.; Patel, S.J.; Wang, W.; Wang, G.; Chan, W.; Rao, K.R.; Alam, J.; Jeyaraj, D.A.; Ngew, X.; Patel, V.; Beer, D.; Lim, S.P.; Vasudevan, S.G.; Keller, T.H.
Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead
Bioorg. Med. Chem. Lett.
16
36-39
2006
Dengue virus
Manually annotated by BRENDA team
Yin, Z.; Patel, S.J.; Wang, W.; Chan, W.; Ranga Rao, K.R.; Wang, G.; Ngew, X.; Patel, V.; Beer, D.; Knox, J.E.; Ma, N.L.; Ehrhardt, C.; Lim, S.P.; Vasudevan, S.G.; Keller, T.H.
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors
Bioorg. Med. Chem. Lett.
16
40-43
2006
Dengue virus
Manually annotated by BRENDA team
Schrauf, S.; Schlick, P.; Skern, T.; Mandl, C.W.
Functional analysis of potential carboxy-terminal cleavage sites of tick-borne encephalitis virus capsid protein
J. Virol.
82
2218-2229
2008
Flavivirus sp.
Manually annotated by BRENDA team
Shiryaev, S.A.; Radichev, I.A.; Ratnikov, B.I.; Aleshin, A.E.; Gawlik, K.; Stec, B.; Frisch, C.; Knappik, A.; Strongin, A.Y.
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus
Biochem. J.
427
369-376
2010
West Nile virus, West Nile virus NY99
Manually annotated by BRENDA team
Sidique, S.; Shiryaev, S.A.; Ratnikov, B.I.; Herath, A.; Su, Y.; Strongin, A.Y.; Cosford, N.D.
Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase
Bioorg. Med. Chem. Lett.
19
5773-5777
2009
West Nile virus
Manually annotated by BRENDA team
Schueller, A.; Yin, Z.; Brian Chia, C.S.; Doan, D.N.; Kim, H.K.; Shang, L.; Loh, T.P.; Hill, J.; Vasudevan, S.G.
Tripeptide inhibitors of dengue and West Nile virus NS2B-NS3 protease
Antiviral Res.
92
96-101
2011
Dengue virus, West Nile virus
Manually annotated by BRENDA team
Kondo, M.Y.; Oliveira, L.C.; Okamoto, D.N.; de Araujo, M.R.; Duarte dos Santos, C.N.; Juliano, M.A.; Juliano, L.; Gouvea, I.E.
Yellow fever virus NS2B/NS3 protease: hydrolytic properties and substrate specificity
Biochem. Biophys. Res. Commun.
407
640-644
2011
Yellow fever virus
Manually annotated by BRENDA team
Kannappan, P.; Narayanan, S.
Mutation and docking studies on NS2b-NS3 complex from yellow fever virus towards drug discovery
Bioinformation
6
303-306
2011
Yellow fever virus
Manually annotated by BRENDA team
Condotta, S.A.; Martin, M.M.; Boutin, M.; Jean, F.
Detection and in-cell selectivity profiling of the full-length West Nile virus NS2B/NS3 serine protease using membrane-anchored fluorescent substrates
Biol. Chem.
391
549-559
2010
West Nile virus
Manually annotated by BRENDA team
Phong, W.Y.; Moreland, N.J.; Lim, S.P.; Wen, D.; Paradkar, P.N.; Vasudevan, S.G.
Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target
Biosci. Rep.
31
399-409
2011
Dengue virus type 2
Manually annotated by BRENDA team
Lim, H.A.; Joy, J.; Hill, J.; San Brian Chia, C.
Novel agmatine and agmatine-like peptidomimetic inhibitors of the West Nile virus NS2B/NS3 serine protease
Eur. J. Med. Chem.
46
3130-3134
2011
West Nile virus
Manually annotated by BRENDA team
Frimayanti, N.; Chee, C.F.; Zain, S.M.; Rahman, N.A.
Design of new competitive dengue ns2b/ns3 protease inhibitors-a computational approach
Int. J. Mol. Sci.
12
1089-1100
2011
Dengue virus
Manually annotated by BRENDA team
de la Cruz, L.; Nguyen, T.H.; Ozawa, K.; Shin, J.; Graham, B.; Huber, T.; Otting, G.
Binding of Low Molecular Weight Inhibitors Promotes Large Conformational Changes in the Dengue Virus NS2B-NS3 Protease: Fold Analysis by Pseudocontact Shifts
J. Am. Chem. Soc.
133
19205-19215
2011
Dengue virus type 2
Manually annotated by BRENDA team
Luo, D.; Wei, N.; Doan, D.N.; Paradkar, P.N.; Chong, Y.; Davidson, A.D.; Kotaka, M.; Lescar, J.; Vasudevan, S.G.
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications
J. Biol. Chem.
285
18817-18827
2010
Dengue virus type 2, Dengue virus type 4 (Q2YHF0)
Manually annotated by BRENDA team
Salaemae, W.; Junaid, M.; Angsuthanasombat, C.; Katzenmeier, G.
Structure-guided mutagenesis of active site residues in the dengue virus two-component protease NS2B-NS3
J. Biomed. Sci.
17
68
2010
Dengue virus
Manually annotated by BRENDA team
Frecer, V.; Miertus, S.
Design, structure-based focusing and in silico screening of combinatorial library of peptidomimetic inhibitors of Dengue virus NS2B-NS3 protease
J. Comput. Aided Mol. Des.
24
195-212
2010
Dengue virus type 2
Manually annotated by BRENDA team
Wu, H.; Bock, S.; Snitko, M.; Berger, T.; Weidner, T.; Holloway, S.; Kanitz, M.; Diederich, W.E.; Steuber, H.; Walter, C.; Hofmann, D.; Weissbrich, B.; Spannaus, R.; Acosta, E.G.; Bartenschlager, R.; Engels, B.; Schirmeister, T.; Bodem, J.
Novel dengue virus NS2B/NS3 protease inhibitors
Antimicrob. Agents Chemother.
59
1100-1109
2015
Dengue virus
Manually annotated by BRENDA team
Verma, R.; Jatav, V.; Sharma, S.
Identification of inhibitors of dengue virus (Denv1, Denv2 and Denv3) NS2B/NS3 serine protease: A molicular docking and simulation approach
Asian J. Pharm. Clin. Res.
8
287-292
2015
Dengue virus
-
Manually annotated by BRENDA team
Junaid, M.; Angsuthanasombat, C.; Wikberg, J.E.; Ali, N.; Katzenmeier, G.
A straightforward experimental approach to expression, purification, refolding, and enzymatic analysis of recombinant dengue virus NS2B(H)-NS3pro protease
Biochemistry (Moscow)
78
920-924
2013
Dengue virus
Manually annotated by BRENDA team
Choksupmanee, O.; Hodge, K.; Katzenmeier, G.; Chimnaronk, S.
Structural platform for the autolytic activity of an intact NS2B-NS3 protease complex from dengue virus
Biochemistry
51
2840-2851
2012
Dengue virus
Manually annotated by BRENDA team
Senthilvel, P.; Lavanya, P.; Kumar, K.M.; Swetha, R.; Anitha, P.; Bag, S.; Sarveswari, S.; Vijayakumar, V.; Ramaiah, S.; Anbarasu, A.
Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents Dengue 2 viral assembly
Bioinformation
9
889-895
2013
Dengue virus
Manually annotated by BRENDA team
Liu, H.; Wu, R.; Sun, Y.; Ye, Y.; Chen, J.; Luo, X.; Shen, X.; Liu, H.
Identification of novel thiadiazoloacrylamide analogues as inhibitors of dengue-2 virus NS2B/NS3 protease
Bioorg. Med. Chem.
22
6344-6352
2014
Dengue virus
Manually annotated by BRENDA team
de Sousa, L.R.; Wu, H.; Nebo, L.; Fernandes, J.B.; da Silva, M.F.; Kiefer, W.; Kanitz, M.; Bodem, J.; Diederich, W.E.; Schirmeister, T.; Vieira, P.C.
Flavonoids as noncompetitive inhibitors of Dengue virus NS2B-NS3 protease: inhibition kinetics and docking studies
Bioorg. Med. Chem.
23
466-470
2015
Dengue virus
Manually annotated by BRENDA team
Li, L.; Basavannacharya, C.; Chan, K.W.; Shang, L.; Vasudevan, S.G.; Yin, Z.
Structure-guided discovery of a novel non-peptide inhibitor of dengue virus NS2B-NS3 protease
Chem. Biol. Drug Des.
86
255-264
2015
Dengue virus
Manually annotated by BRENDA team
Ang, M.J.; Yong, G.H.; Poulsen, A.; Then, S.W.; Li, Z.; Joy, J.; Hill, J.; Chia, C.S.
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study
Eur. J. Med. Chem.
68
72-80
2013
Murray Valley encephalitis virus
Manually annotated by BRENDA team
de la Cruz, L.; Chen, W.N.; Graham, B.; Otting, G.
Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease
FEBS J.
281
1517-1533
2014
Dengue virus (Q91H74), Dengue virus
Manually annotated by BRENDA team
Chen, W.N.; Loscha, K.V.; Nitsche, C.; Graham, B.; Otting, G.
The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI
FEBS Lett.
588
2206-2211
2014
Dengue virus (Q91H74), Dengue virus
Manually annotated by BRENDA team
Nguyen, T.; Lee, S.; Wang, H.; Chen, H.; Wu, Y.; Lin, S.; Kim, D.; Kim, D.
In vitro evaluation of novel inhibitors against the NS2B-NS3 protease of dengue fever virus type 4
Molecules
18
15600-15612
2013
Dengue virus
Manually annotated by BRENDA team
Ang, M.J.; Li, Z.; Lim, H.A.; Ng, F.M.; Then, S.W.; Wee, J.L.; Joy, J.; Hill, J.; Chia, C.S.
A P2 and P3 substrate specificity comparison between the Murray Valley encephalitis and West Nile virus NS2B/NS3 protease using C-terminal agmatine dipeptides
Peptides
52
49-52
2014
West Nile virus, Murray Valley encephalitis virus
Manually annotated by BRENDA team
Huang, Q.; Li, Q.; Joy, J.; Chen, A.S.; Ruiz-Carrillo, D.; Hill, J.; Lescar, J.; Kang, C.
Lyso-myristoyl phosphatidylcholine micelles sustain the activity of Dengue non-structural (NS) protein 3 protease domain fused with the full-length NS2B
Protein Expr. Purif.
92
156-162
2013
Dengue virus
Manually annotated by BRENDA team
Hill, M.E.; Kumar, A.; Wells, J.A.; Hobman, T.C.; Julien, O.; Hardy, J.A.
The unique cofactor region of zika virus NS2B-NS3 protease facilitates cleavage of key host proteins
ACS Chem. Biol.
13
2398-2405
2018
Zika virus
Manually annotated by BRENDA team
Luo, D.; Vasudevan, S.G.; Lescar, J.
The flavivirus NS2B-NS3 protease-helicase as a target for antiviral drug development
Antiviral Res.
118
148-158
2015
Yellow fever virus (P03314), Murray Valley encephalitis virus (P05769), West Nile virus (P06935), Kunjin virus (P14335), dengue virus type I (P17763), Japanese encephalitis virus (P27395), Dengue virus type 2 (P29990), Dengue virus type 4 (Q2YHF0), Kokobera virus (Q32ZD5), Dengue virus type 3 (Q6YMS3), Dengue virus type 2 Thailand/16681/1984 (P29990), Dengue virus type 3 Martinique/1243/1999 (Q6YMS3), Yellow fever virus 17D vaccine (P03314), Dengue virus type 4 Thailand/0348/1991 (Q2YHF0), dengue virus type I Nauru/West Pac/1974 (P17763), Japanese encephalitis virus SA-14 (P27395), Kunjin virus MRM61C (P14335), Murray Valley encephalitis virus MVE-1-51 (P05769)
Manually annotated by BRENDA team
Rut, W.; Zhang, L.; Kasperkiewicz, P.; Poreba, M.; Hilgenfeld, R.; Drag, M.
Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease
Antiviral Res.
139
88-94
2017
Zika virus (A0A024B7W1), Zika virus
Manually annotated by BRENDA team
Shiryaev, S.A.; Farhy, C.; Pinto, A.; Huang, C.T.; Simonetti, N.; Elong Ngono, A.; Dewing, A.; Shresta, S.; Pinkerton, A.B.; Cieplak, P.; Strongin, A.Y.; Terskikh, A.V.
Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists
Antiviral Res.
143
218-229
2017
Zika virus (A0A024B7W1), Zika virus
Manually annotated by BRENDA team
Zhu, L.; Yang, J.; Li, H.; Sun, H.; Liu, J.; Wang, J.
Conformational change study of dengue virus NS2B-NS3 protease using 19F NMR spectroscopy
Biochem. Biophys. Res. Commun.
461
677-680
2015
Dengue virus type 2
Manually annotated by BRENDA team
Aguilera-Pesantes, D.; Robayo, L.E.; Mendez, P.E.; Mollocana, D.; Marrero-Ponce, Y.; Torres, F.J.; Mendez, M.A.
Discovering key residues of dengue virus NS2b-NS3-protease new binding sites for antiviral inhibitors design
Biochem. Biophys. Res. Commun.
492
631-642
2017
Dengue virus type 3 (Q5UB51), Dengue virus type 3 Singapore/8120/1995 (Q5UB51)
Manually annotated by BRENDA team
Kuiper, B.D.; Slater, K.; Spellmon, N.; Holcomb, J.; Medapureddy, P.; Muzzarelli, K.M.; Yang, Z.; Ovadia, R.; Amblard, F.; Kovari, I.A.; Schinazi, R.F.; Kovari, L.C.
Increased activity of unlinked Zika virus NS2B/NS3 protease compared to linked Zika virus protease
Biochem. Biophys. Res. Commun.
492
668-673
2017
Zika virus (A0A384KRS4), Zika virus, Zika virus Puerto Rico isolate (A0A384KRS4)
Manually annotated by BRENDA team
Balajee, R.; Srinivasadesikan, V.; Sakthivadivel, M.; Gunasekaran, P.
In silico screening, alanine mutation, and DFT approaches for identification of NS2B/NS3 protease inhibitors
Biochem. Res. Int.
2016
7264080
2016
Dengue virus type 2
Manually annotated by BRENDA team
Hill, M.E.; Yildiz, M.; Hardy, J.A.
Cysteine disulfide traps reveal distinct conformational ensembles in dengue virus NS2B-NS3 protease
Biochemistry
58
776-787
2019
Dengue virus type 2 (P29990), Dengue virus type 2 Thailand/16681/1984 (P29990)
Manually annotated by BRENDA team
Takagi, Y.; Matsui, K.; Nobori, H.; Maeda, H.; Sato, A.; Kurosu, T.; Orba, Y.; Sawa, H.; Hattori, K.; Higashino, K.; Numata, Y.; Yoshida, Y.
Discovery of novel cyclic peptide inhibitors of dengue virus NS2B-NS3 protease with antiviral activity
Bioorg. Med. Chem. Lett.
27
3586-3590
2017
Dengue virus type 2
Manually annotated by BRENDA team
Weng, Z.; Shao, X.; Graf, D.; Wang, C.; Klein, C.D.; Wang, J.; Zhou, G.C.
Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors
Eur. J. Med. Chem.
125
751-759
2017
Dengue virus type 2
Manually annotated by BRENDA team
Gruba, N.; Rodriguez Martinez, J.I.; Grzywa, R.; Wysocka, M.; Skorenski, M.; Burmistrz, M.; Lecka, M.; Lesner, A.; Sienczyk, M.; Pyrc, K.
Substrate profiling of Zika virus NS2B-NS3 protease
FEBS Lett.
590
3459-3468
2016
Zika virus (Q32ZE1), Zika virus
Manually annotated by BRENDA team
Li, Y.; Phoo, W.W.; Loh, Y.R.; Zhang, Z.; Ng, E.Y.; Wang, W.; Keller, T.H.; Luo, D.; Kang, C.
Structural characterization of the linked NS2B-NS3 protease of Zika virus
FEBS Lett.
591
2338-2347
2017
Zika virus
Manually annotated by BRENDA team
Yao, Y.; Huo, T.; Lin, Y.L.; Nie, S.; Wu, F.; Hua, Y.; Wu, J.; Kneubehl, A.R.; Vogt, M.B.; Rico-Hesse, R.; Song, Y.
Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease
J. Am. Chem. Soc.
141
6832-6836
2019
Dengue virus, West Nile virus, Zika virus
Manually annotated by BRENDA team
Kouretova, J.; Hammamy, M.Z.; Epp, A.; Hardes, K.; Kallis, S.; Zhang, L.; Hilgenfeld, R.; Bartenschlager, R.; Steinmetzer, T.
Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication
J. Enzyme Inhib. Med. Chem.
32
712-721
2017
Dengue virus, West Nile virus
Manually annotated by BRENDA team
Skorenski, M.; Milewska, A.; Pyrc, K.; Sienczyk, M.; Oleksyszyn, J.
Phosphonate inhibitors of West Nile virus NS2B/NS3 protease
J. Enzyme Inhib. Med. Chem.
34
8-14
2019
West Nile virus
Manually annotated by BRENDA team
Yotmanee, P.; Rungrotmongkol, T.; Wichapong, K.; Choi, S.B.; Wahab, H.A.; Kungwan, N.; Hannongbua, S.
Binding specificity of polypeptide substrates in NS2B/NS3pro serine protease of dengue virus type 2 A molecular dynamics study
J. Mol. Graph. Model.
60
24-33
2015
Dengue virus type 2 (Q91H74), Dengue virus type 2 Thailand/NGS-C/1944 (Q91H74)
Manually annotated by BRENDA team
Phoo, W.W.; Li, Y.; Zhang, Z.; Lee, M.Y.; Loh, Y.R.; Tan, Y.B.; Ng, E.Y.; Lescar, J.; Kang, C.; Luo, D.
Structure of the NS2B-NS3 protease from Zika virus after self-cleavage
Nat. Commun.
7
13410
2016
Zika virus (H8XX12), Zika virus
Manually annotated by BRENDA team
Woestenenk, E.; Agback, P.; Unnerstale, S.; Henderson, I.; Agback, T.
Co-refolding of a functional complex of Dengue NS3 protease and NS2B co-factor domain and backbone resonance assignment by solution NMR
Protein Expr. Purif.
140
16-27
2017
Dengue virus
Manually annotated by BRENDA team
Lei, J.; Hansen, G.; Nitsche, C.; Klein, C.D.; Zhang, L.; Hilgenfeld, R.
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor
Science
353
503-505
2016
Zika virus (A0A140DLX4), Zika virus, Zika virus Brazilian isolate BeH823339 (A0A140DLX4)
Manually annotated by BRENDA team
Zhang, Z.; Li, Y.; Loh, Y.R.; Phoo, W.W.; Hung, A.W.; Kang, C.; Luo, D.
Crystal structure of unlinked NS2B-NS3 protease from Zika virus
Science
354
1597-1600
2016
Zika virus
Manually annotated by BRENDA team
Li, Y.; Zhang, Z.; Phoo, W.W.; Loh, Y.R.; Wang, W.; Liu, S.; Chen, M.W.; Hung, A.W.; Keller, T.H.; Luo, D.; Kang, C.
Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors
Structure
25
1242-1250
2017
Zika virus
Manually annotated by BRENDA team
Li, Y.; Zhang, Z.; Phoo, W.W.; Loh, Y.R.; Li, R.; Yang, H.Y.; Jansson, A.E.; Hill, J.; Keller, T.H.; Nacro, K.; Luo, D.; Kang, C.
Structural insights into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor
Structure
26
555-564.e3
2018
Zika virus
Manually annotated by BRENDA team