Disease on EC 3.4.21.76 - Myeloblastin
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Acquired Immunodeficiency Syndrome
Discrepancies between two immunoassays for the determination of MPO and PR3 autoantibodies.
Acute Kidney Injury
Aggregatibacter aphrophilus infective endocarditis confirmed by broad-range PCR diagnosis: A case report.
Acute Kidney Injury
Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis.
Acute Kidney Injury
Proliferative glomerulonephritis and mantle cell lymphoma: a rare association.
Acute Lung Injury
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Adenocarcinoma of Lung
KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma.
Alzheimer Disease
[Effect of Active Ingredients of Qingxin Kaiqiao Recipe on Spatial Learning and Memory Capacities, and Expressions of Bax, Bcl-2, Caspase-3, and PAPP in Hippocampus of AD Model Rats].
Anemia
[Difficulties in the differential diagnosis of kidney injury in a patient with infective endocarditis associated with antineutrophil cytoplasmic antibodies].
Anemia, Sickle Cell
[Antineutrophil cytoplasmic antibodies in patients with sickle cell anemia]
Anti-Glomerular Basement Membrane Disease
2020 international consensus on ANCA testing beyond systemic vasculitis.
Anti-Glomerular Basement Membrane Disease
Anti-glomerular basement membrane (anti-GBM) disease accompanied by vasculitis that was not positive for antineutrophil cytoplasmic antibodies to myeloperoxidase and proteinase 3: a report of two cases and the incidence of anti-GBM disease at one institution.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
2020 international consensus on ANCA testing beyond systemic vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Alpha 1-antitrypsin activity is markedly decreased in Wegener's granulomatosis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
ANCA as a Predictor of Relapse: Useful in Patients with Renal Involvement But Not in Patients with Nonrenal Disease.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Anti-neutrophil Cytoplasmic Antibodies (ANCA) as Disease Activity Biomarkers in a "Personalized Medicine Approach" in ANCA-Associated Vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 in ANCA-Associated Vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Comparison of enzyme-linked immunosorbent assay and rapid chemiluminescent analyser in the detection of myeloperoxidase and proteinase 3 autoantibodies.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Diagnostic ANCA algorithms in daily clinical practice: evidence, experience, and effectiveness.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Endothelial tissue factor stimulation by proteinase 3 and elastase.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Factors Determining the Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
IgA- and SIgA anti-PR3 antibodies in serum versus organ involvement and disease activity in PR3-ANCA associated vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Immunoglobulins G from patients with ANCA-associated vasculitis are atypically glycosylated in both the Fc and Fab regions and the relation to disease activity.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Lupus nephritis and ANCA-associated vasculitis: towards precision medicine?
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
No association of G-463A myeloperoxidase gene polymorphism with MPO-ANCA-associated vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis: challenges and solutions 2014.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Serial ANCA titers: useful tool for prevention of relapses in ANCA-associated vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The Diagnostic and Clinical Utility of Autoantibodies in Systemic Vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
The role of myeloperoxidase in the pathogenesis of systemic vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
What you should know about PR3-ANCA. Evidence for the role of T cells in the pathogenesis of systemic vasculitis.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
[ANCA diagnostics in vasculitis].
Antiphospholipid Syndrome
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Arteritis
A case of PR3-ANCA-positive anti-GBM disease associated with intrarenal arteritis and thrombotic microangiopathy.
Arthralgia
A case series and literature review on patients with rhinological complications secondary to the use of cocaine and levamisole.
Arthritis
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Arthritis
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Arthritis
The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.
Arthritis, Reactive
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Arthritis, Rheumatoid
A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Arthritis, Rheumatoid
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Arthritis, Rheumatoid
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Arthritis, Rheumatoid
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.
Arthritis, Rheumatoid
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Arthritis, Rheumatoid
The membrane proteinase 3 expression on neutrophils was downregulated after treatment with infliximab in patients with rheumatoid arthritis.
Atherosclerosis
Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.
Autoimmune Diseases
ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation.
Autoimmune Diseases
Antibodies to proteinase 3 prime human oral, lung, and kidney epithelial cells to secrete proinflammatory cytokines upon stimulation with agonists to various Toll-like receptors, NOD1, and NOD2.
Autoimmune Diseases
Antineutrophil cytoplasmic antibody (ANCA) vasculitis: pathophysiology, diagnosis, and the evolving treatment landscape.
Autoimmune Diseases
Characterization of the CD177 interaction with the ANCA antigen proteinase 3.
Autoimmune Diseases
Discrepancies between two immunoassays for the determination of MPO and PR3 autoantibodies.
Autoimmune Diseases
Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies.
Autoimmune Diseases
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Blast Crisis
Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules.
Blast Crisis
The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia.
Breast Neoplasms
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1.
Breast Neoplasms
Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients.
Breast Neoplasms
Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.
Breast Neoplasms
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Breast Neoplasms
SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
Bronchitis, Chronic
Proteinase 3 Activity in sputum from subjects with Alpha-1-Antitrypsin deficiency and COPD.
Carcinogenesis
Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.
Carcinogenesis
[The expression and significance of smac, XIAP, caspase-3 in nonasal inverted papilloma].
Carcinoma
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Carcinoma
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression.
Carcinoma
[A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]
Carcinoma, Renal Cell
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression.
Carcinoma, Squamous Cell
[A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]
Cerebral Infarction
Remifentanil protects neurological function of rats with cerebral ischemia-reperfusion injury via NR2B/CaMKII? signaling pathway.
Cholangiocarcinoma
Anti-glycoprotein 2 (anti-GP2) IgA and anti-neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3-ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis.
Cholangitis, Sclerosing
Anti-glycoprotein 2 (anti-GP2) IgA and anti-neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3-ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis.
Cholangitis, Sclerosing
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Cholangitis, Sclerosing
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Churg-Strauss Syndrome
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Churg-Strauss Syndrome
Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis.
Churg-Strauss Syndrome
Determination of anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: Comparative analysis of different strategies.
Churg-Strauss Syndrome
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Churg-Strauss Syndrome
Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS).
Churg-Strauss Syndrome
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Churg-Strauss Syndrome
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Churg-Strauss Syndrome
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Churg-Strauss Syndrome
Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction.
Churg-Strauss Syndrome
Re-evaluation of 129 patients with systemic necrotizing vasculitides by using classification algorithm according to consensus methodology.
Churg-Strauss Syndrome
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Churg-Strauss Syndrome
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
Colitis
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Colitis, Collagenous
Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease and Collagenous Colitis: No Association with Lactoferrin, ?-Glucuronidase, Myeloperoxidase, or Proteinase 3.
Colitis, Ulcerative
A subset of ulcerative colitis with positive proteinase-3 antineutrophil cytoplasmic antibody.
Colitis, Ulcerative
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Colitis, Ulcerative
Diagnostic accuracy of serum proteinase 3 antineutrophil cytoplasmic antibodies in children with ulcerative colitis.
Colitis, Ulcerative
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis.
Colitis, Ulcerative
PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.
Colitis, Ulcerative
PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC).
Colitis, Ulcerative
Pulmonary complications resembling Wegener's granulomatosis in ulcerative colitis with elevated proteinase-3 anti-neutrophil cytoplasmic antibody.
Colitis, Ulcerative
[Antineutrophil cytoplasmic antibodies and nonspecific ulcerative colitis]
Communicable Diseases
Proteinase 3 expression on neutrophil membranes from patients with infectious disease.
Communicable Diseases
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Connective Tissue Diseases
Clinical significance of thyroid hormone and antibodies in patients with idiopathic interstitial pneumonia.
COVID-19
The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression.
Crohn Disease
PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.
Cystic Fibrosis
Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts.
Cystic Fibrosis
Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo.
Cystic Fibrosis
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Cystic Fibrosis
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease.
Cystic Fibrosis
Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis.
Cystic Fibrosis
Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.
Deafness
Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.
Diabetes Mellitus
[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
Diabetes Mellitus
[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults].
Diabetes Mellitus, Type 1
Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with ?-cell autoimmunity in patients with type 1 diabetes.
Diabetes Mellitus, Type 1
[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
Diabetes Mellitus, Type 1
[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults].
Diabetes Mellitus, Type 2
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Diabetes Mellitus, Type 2
The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study.
Diabetes Mellitus, Type 2
[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults].
Diabetic Ketoacidosis
Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Embolism, Cholesterol
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review.
Endocarditis
A Japanese case of proteinase 3 antineutrophil cytoplasmic autoantibody-associated pauci-immune-type crescentic glomerulonephritis without valvular endocarditis.
Endocarditis
Antineutrophil cytoplasmic antibodies (ANCA)-positive patient with infective endocarditis and chronic hepatitis B virus: a case report and review of the literature.
Endocarditis, Bacterial
Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis.
Endocarditis, Bacterial
Bacterial endocarditis associated with proteinase 3 anti-neutrophil cytoplasm antibody.
Endocarditis, Subacute Bacterial
The presence of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) in the course of subacute bacterial endocarditis with glomerular involvement, coincidence or association?
Eosinophilia
Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase.
Epididymitis
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Facial Paralysis
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Fatty Liver
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Fatty Liver
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Fatty Liver
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Glioblastoma
Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail.
Glomerulonephritis
A Japanese case of proteinase 3 antineutrophil cytoplasmic autoantibody-associated pauci-immune-type crescentic glomerulonephritis without valvular endocarditis.
Glomerulonephritis
ANCA-associated pauci-immune glomerulonephritis in a patient with bacterial endocarditis: a challenging clinical dilemma.
Glomerulonephritis
ANCA-positive crescentic glomerulonephritis associated with minocycline therapy.
Glomerulonephritis
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders.
Glomerulonephritis
Antineutrophil cytoplasmic autoantibodies-antigen specificity and associated diseases.
Glomerulonephritis
Complement Components C3 and C4 Indicate Vasculitis Manifestations to Distinct Renal Compartments in ANCA-Associated Glomerulonephritis.
Glomerulonephritis
Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis.
Glomerulonephritis
Diagnostic algorithm for antineutrophil cytoplasmic antibody-associated systemic vasculitis.
Glomerulonephritis
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Glomerulonephritis
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.
Glomerulonephritis
Dual anti-neutrophil cytoplasmic antibody-related pauci-immune crescentic glomerulonephritis in a patient with Sjögren's syndrome.
Glomerulonephritis
Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study.
Glomerulonephritis
In vitro neutrophil activation by antibodies to proteinase 3 and myeloperoxidase from patients with crescentic glomerulonephritis.
Glomerulonephritis
Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.
Glomerulonephritis
PR3 and Elastase Alter PAR1 Signaling and Trigger vWF Release via a Calcium-Independent Mechanism from Glomerular Endothelial Cells.
Glomerulonephritis
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Glomerulonephritis
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Glomerulonephritis
Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Glomerulonephritis
Rapid screening assay for anti-GBM antibody and ANCAs; an important tool for the differential diagnosis of pulmonary renal syndromes.
Glomerulonephritis
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Glomerulonephritis
Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice.
Glomerulonephritis
Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis.
Glomerulonephritis
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Glomerulonephritis
Valvular injury in a patient with PR3-ANCA-associated glomerulonephritis.
Glomerulonephritis
Vasculitis following implantation of a ventriculoperitoneal shunt tube made of silicone.
Glomerulonephritis
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
Glomerulonephritis
[A case of refractory Wegener's granulomatosis successfully treated with high-dose methotrexate]
Glomerulonephritis
[Rapid-detection GBM-ANCA ELISA. An emergency tool for the early diagnosis of type I and II rapidly progressive glomerulonephritis]
Glomerulonephritis, IGA
Is presence of ANCA in crescentic IgA nephropathy a coincidence or novel clinical entity? A case series.
Granuloma
Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease.
Granuloma
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Granuloma
Should nasal biopsy inevitably be performed for classifying granulomatosis with polyangiitis in patients with rhinosinusitis? A retrospective chart review study.
Granuloma
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.
Granulomatosis with Polyangiitis
'Classic' anti-neutrophil cytoplasmic autoantibodies (cANCA), 'Wegener's autoantigen' and their immunopathogenic role in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
18F-FDG PET/CT Findings Preceded Elevation of Serum Proteinase 3 Antineutrophil Cytoplasmic Antibodies in Wegener Granulomatosis.
Granulomatosis with Polyangiitis
4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis.
Granulomatosis with Polyangiitis
A case of (double) ANCA-negative granulomatosis with polyangiitis (Wegener's).
Granulomatosis with Polyangiitis
A Case of Suspected Hepatically Localized Granulomatosis with Polyangiitis.
Granulomatosis with Polyangiitis
A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement.
Granulomatosis with Polyangiitis
A Case Report on Suspected Levamisole-Induced Pseudovasculitis.
Granulomatosis with Polyangiitis
A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis.
Granulomatosis with Polyangiitis
A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors.
Granulomatosis with Polyangiitis
A Monoclonal Antibody (MCPR3-7) Interfering with the Activity of Proteinase 3 by an Allosteric Mechanism.
Granulomatosis with Polyangiitis
A new approach to the molecular characterization of the c-ANCA antigen in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
A novel high sensitivity ELISA for detection of antineutrophil cytoplasm antibodies against proteinase-3.
Granulomatosis with Polyangiitis
A review of immunofluorescent patterns associated with antineutrophil cytoplasmic antibodies (ANCA) and their differentiation from other antibodies.
Granulomatosis with Polyangiitis
A simple high yield procedure for purification of human proteinase 3, the main molecular target of cANCA.
Granulomatosis with Polyangiitis
A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen.
Granulomatosis with Polyangiitis
Advances in pathogenesis and treatment of ANCA-associated vasculitis.
Granulomatosis with Polyangiitis
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.
Granulomatosis with Polyangiitis
Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis.
Granulomatosis with Polyangiitis
Alpha 1-antitrypsin phenotypes in patients with anti-neutrophil cytoplasmic antibody-positive vasculitis.
Granulomatosis with Polyangiitis
Alterations of serum levels of plasminogen, TNF-?, and IDO in granulomatosis with polyangiitis patients.
Granulomatosis with Polyangiitis
Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Analysis of T-cell receptor usage in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
Granulomatosis with Polyangiitis
ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives.
Granulomatosis with Polyangiitis
Anti-cytoplasmic antibodies in Wegener's granulomatosis are directed against proteinase 3.
Granulomatosis with Polyangiitis
Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass.
Granulomatosis with Polyangiitis
Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site.
Granulomatosis with Polyangiitis
Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa.
Granulomatosis with Polyangiitis
Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis.
Granulomatosis with Polyangiitis
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Granulomatosis with Polyangiitis
Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation.
Granulomatosis with Polyangiitis
Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells.
Granulomatosis with Polyangiitis
Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1).
Granulomatosis with Polyangiitis
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic antibodies (ANCA) and systemic vasculitis: update of assays, immunopathogenesis, controversies, and report of a novel de novo ANCA-associated vasculitis after kidney transplantation.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis and other diseases: clinical issues.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: epitope analysis using synthetic peptides.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis recognize conformational epitope(s) on proteinase 3.
Granulomatosis with Polyangiitis
Antineutrophil cytoplasmic autoantibodies-antigen specificity and associated diseases.
Granulomatosis with Polyangiitis
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
Granulomatosis with Polyangiitis
Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Granulomatosis with Polyangiitis
Autoantibodies to neutrophil cytoplasmic antigens (ANCA) do not bind to polymorphonuclear neutrophils in blood.
Granulomatosis with Polyangiitis
B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions.
Granulomatosis with Polyangiitis
Bilateral Facial Nerve Palsy due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody.
Granulomatosis with Polyangiitis
Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?
Granulomatosis with Polyangiitis
Blindness in a Sri Lankan woman with bilateral breast lumps: a case report.
Granulomatosis with Polyangiitis
c-ANCA induce neutrophil-mediated lung injury -a model of acute Wegener's Granulomatosis.
Granulomatosis with Polyangiitis
Capture-ELISA based on recombinant PR3 is sensitive for PR3-ANCA testing and allows detection of PR3 and PR3-ANCA/PR3 immunecomplexes.
Granulomatosis with Polyangiitis
Changes in proteinase 3 anti-neutrophil cytoplasm autoantibody levels in early systemic granulomatosis with polyangiitis (Wegener's) may reflect treatment rather than disease activity.
Granulomatosis with Polyangiitis
Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2).
Granulomatosis with Polyangiitis
Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies.
Granulomatosis with Polyangiitis
Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3.
Granulomatosis with Polyangiitis
Characterization of monoclonal antibodies to proteinase-3 and application in the study of epitopes for classical anti-neutrophil cytoplasm antibodies.
Granulomatosis with Polyangiitis
Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3.
Granulomatosis with Polyangiitis
Clinical and prognostic features of Korean patients with MPO-ANCA, PR3-ANCA and ANCA-negative vasculitis.
Granulomatosis with Polyangiitis
Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan otological society.
Granulomatosis with Polyangiitis
Clinical features and outcome in patients with glomerulonephritis and antineutrophil cytoplasmic autoantibodies.
Granulomatosis with Polyangiitis
Clinically-irrelevant positivity for serum proteinase 3-ANCA in HIV disease.
Granulomatosis with Polyangiitis
Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis.
Granulomatosis with Polyangiitis
Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils.
Granulomatosis with Polyangiitis
Comparative investigation of respiratory tract involvement in granulomatosis with polyangiitis between PR3-ANCA positive and MPO-ANCA positive cases: a retrospective cohort study.
Granulomatosis with Polyangiitis
Complexes between proteinase 3, alpha 1-antitrypsin and proteinase 3 anti-neutrophil cytoplasm autoantibodies: a comparison between alpha 1-antitrypsin PiZ allele carriers and non-carriers with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
Granulomatosis with Polyangiitis
Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies.
Granulomatosis with Polyangiitis
Current State of Biologicals in the Management of Systemic Vasculitis.
Granulomatosis with Polyangiitis
Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.
Granulomatosis with Polyangiitis
Detachment and cytolysis of human endothelial cells by proteinase 3.
Granulomatosis with Polyangiitis
Determination of anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: Comparative analysis of different strategies.
Granulomatosis with Polyangiitis
Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease.
Granulomatosis with Polyangiitis
Different forms of alpha-1 antitrypsin and neutrophil activation mediated by human anti-PR3 IgG antibodies.
Granulomatosis with Polyangiitis
Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.
Granulomatosis with Polyangiitis
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Granulomatosis with Polyangiitis
Distinct proteinase 3-induced cytokine patterns in Wegener´s granulomatosis, Churg-Strauss syndrome, and healthy controls.
Granulomatosis with Polyangiitis
Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology.
Granulomatosis with Polyangiitis
Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA.
Granulomatosis with Polyangiitis
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Granulomatosis with Polyangiitis
Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3.
Granulomatosis with Polyangiitis
Epitope mapping on Wegener's granulomatosis autoantigen proteinase 3.
Granulomatosis with Polyangiitis
Epitope-specific anti-neutrophil cytoplasmic antibodies: do they matter? Can they be detected?
Granulomatosis with Polyangiitis
Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study.
Granulomatosis with Polyangiitis
Expression of recombinant proteinase 3, the autoantigen in Wegener's granulomatosis, in insect cells.
Granulomatosis with Polyangiitis
Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies.
Granulomatosis with Polyangiitis
Frequency of proteinase 3 (PR3)-specific autoreactive T cells determined by cytokine flow cytometry in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Fulminant Wegener's granulomatosis presenting as epistaxis.
Granulomatosis with Polyangiitis
Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis.
Granulomatosis with Polyangiitis
Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3.
Granulomatosis with Polyangiitis
Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.
Granulomatosis with Polyangiitis
Genetic variants in ANCA-associated vasculitis: a meta-analysis.
Granulomatosis with Polyangiitis
Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.
Granulomatosis with Polyangiitis
Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?
Granulomatosis with Polyangiitis
High-sensitivity detection of autoantibodies against proteinase-3 by a novel third-generation enzyme-linked immunosorbent assay.
Granulomatosis with Polyangiitis
Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Image analysis: a novel approach for the quantification of antineutrophil cytoplasmic antibody levels in patients with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Immunity in the connective tissue diseases. The humoral side of the coin.
Granulomatosis with Polyangiitis
Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration.
Granulomatosis with Polyangiitis
Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis.
Granulomatosis with Polyangiitis
Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis.
Granulomatosis with Polyangiitis
Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression.
Granulomatosis with Polyangiitis
Immunologic markers for differentiation of autoimmune responses.
Granulomatosis with Polyangiitis
In situ detection of PR3-ANCA+ B cells and alterations in the variable region of immunoglobulin genes support a role of inflamed tissue in the emergence of auto-reactivity in granulomatosis with polyangiitis.
Granulomatosis with Polyangiitis
In vitro interactions of c-ANCA (antibodies to proteinase 3) with human endothelial cells.
Granulomatosis with Polyangiitis
In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG).
Granulomatosis with Polyangiitis
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.
Granulomatosis with Polyangiitis
Increased expression of the secretory leukocyte proteinase inhibitor in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Induction of proteinase 3-anti-neutrophil cytoplasmic autoantibodies by proteinase 3-homologous bacterial protease in mice.
Granulomatosis with Polyangiitis
Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.
Granulomatosis with Polyangiitis
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation.
Granulomatosis with Polyangiitis
Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils.
Granulomatosis with Polyangiitis
Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers.
Granulomatosis with Polyangiitis
Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity.
Granulomatosis with Polyangiitis
Isolation of a protein complex from purulent sputum consisting of proteinase-3 and alpha 1-antitrypsin reactive with anti neutrophil cytoplasmic antibodies.
Granulomatosis with Polyangiitis
Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.
Granulomatosis with Polyangiitis
Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3.
Granulomatosis with Polyangiitis
Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study.
Granulomatosis with Polyangiitis
Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides.
Granulomatosis with Polyangiitis
Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS).
Granulomatosis with Polyangiitis
Membrane proteinase 3 expression and ANCA-induced neutrophil activation.
Granulomatosis with Polyangiitis
Membrane proteinase 3 expression in patients with Wegener's granulomatosis and in human hematopoietic stem cell-derived neutrophils.
Granulomatosis with Polyangiitis
Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation.
Granulomatosis with Polyangiitis
Membrane-bound proteinase 3 and its receptors: Relevance for the pathogenesis of Wegener's Granulomatosis.
Granulomatosis with Polyangiitis
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Granulomatosis with Polyangiitis
Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.
Granulomatosis with Polyangiitis
Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China.
Granulomatosis with Polyangiitis
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
Granulomatosis with Polyangiitis
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Granulomatosis with Polyangiitis
Neutrophil granule proteins as targets of leukemia-specific immune responses.
Granulomatosis with Polyangiitis
Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis.
Granulomatosis with Polyangiitis
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
Granulomatosis with Polyangiitis
Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177.
Granulomatosis with Polyangiitis
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Granulomatosis with Polyangiitis
Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis).
Granulomatosis with Polyangiitis
Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene.
Granulomatosis with Polyangiitis
On the origin of surface proteinase 3 of nonmyeloid cells: evidence favoring an exogenous source.
Granulomatosis with Polyangiitis
Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention.
Granulomatosis with Polyangiitis
Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Granulomatosis with Polyangiitis
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Granulomatosis with Polyangiitis
Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study.
Granulomatosis with Polyangiitis
Performance evaluation of three assays for the detection of PR3-ANCA in granulomatosis with polyangiitis in daily practice.
Granulomatosis with Polyangiitis
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Granulomatosis with Polyangiitis
Positive c-ANCA in a Patient with Lymphoma and Without Vasculitis.
Granulomatosis with Polyangiitis
Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study.
Granulomatosis with Polyangiitis
Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules.
Granulomatosis with Polyangiitis
Proposal for a more practical classification of antineutrophil cytoplasmic antibody-associated vasculitis.
Granulomatosis with Polyangiitis
Protein microarrays with carbon nanotubes as multicolor Raman labels.
Granulomatosis with Polyangiitis
Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1.
Granulomatosis with Polyangiitis
Proteinase 3 gene polymorphisms and Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical vein endothelial cells.
Granulomatosis with Polyangiitis
Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.
Granulomatosis with Polyangiitis
Proteinase 3 is a phosphatidylserine binding protein which affects the production and function of microvesicles.
Granulomatosis with Polyangiitis
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
Granulomatosis with Polyangiitis
Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Granulomatosis with Polyangiitis
Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.
Granulomatosis with Polyangiitis
Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues.
Granulomatosis with Polyangiitis
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.
Granulomatosis with Polyangiitis
Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme.
Granulomatosis with Polyangiitis
Proteinase-3 antineutrophil cytoplasm antibody positivity in patients without primary systemic vasculitis.
Granulomatosis with Polyangiitis
Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3.
Granulomatosis with Polyangiitis
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.
Granulomatosis with Polyangiitis
Pulmonary capillaritis in Wegener's granulomatosis detected via transbronchial lung biopsy.
Granulomatosis with Polyangiitis
Pulmonary complications resembling Wegener's granulomatosis in ulcerative colitis with elevated proteinase-3 anti-neutrophil cytoplasmic antibody.
Granulomatosis with Polyangiitis
Purification of Wegener's granulomatosis autoantigen, proteinase 3, from neutrophils by Triton X-114 extraction of azurophilic granules.
Granulomatosis with Polyangiitis
Recombinant proteinase 3 produced in different expression systems: recognition by anti-PR3 antibodies.
Granulomatosis with Polyangiitis
Relation between asymptomatic proteinase 3 antibodies and future granulomatosis with polyangiitis.
Granulomatosis with Polyangiitis
Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-alpha 1-antitrypsin complexation to disease activity in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors.
Granulomatosis with Polyangiitis
Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis.
Granulomatosis with Polyangiitis
Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's).
Granulomatosis with Polyangiitis
Role of ANCA in the pathogenesis of Wegener's granulomatosis: a short review.
Granulomatosis with Polyangiitis
Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmic antibodies (ANCA). A report of 3 cases and a review of the literature.
Granulomatosis with Polyangiitis
Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions.
Granulomatosis with Polyangiitis
Structural analysis of human antibodies to proteinase 3 from patients with Wegener granulomatosis.
Granulomatosis with Polyangiitis
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
Granulomatosis with Polyangiitis
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Granulomatosis with Polyangiitis
Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis.
Granulomatosis with Polyangiitis
T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG).
Granulomatosis with Polyangiitis
The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity.
Granulomatosis with Polyangiitis
The binding of proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) varies in different ELISAs.
Granulomatosis with Polyangiitis
The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies.
Granulomatosis with Polyangiitis
The influence of different cultivating conditions on polymorphonuclear leukocyte apoptotic process in vitro, II: ultrastructural characteristics of PMN populations incubated with proteinase 3 anti-neutrophil autoantibodies.
Granulomatosis with Polyangiitis
The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558.
Granulomatosis with Polyangiitis
The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC.
Granulomatosis with Polyangiitis
The role of the c-ANCA antigen in the pathogenesis of Wegener's granulomatosis. A hypothesis based on both humoral and cellular mechanisms.
Granulomatosis with Polyangiitis
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Granulomatosis with Polyangiitis
Treatment of granulomatosis with polyangiitis (Wegener's).
Granulomatosis with Polyangiitis
Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis.
Granulomatosis with Polyangiitis
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.
Granulomatosis with Polyangiitis
Wegener's granulomatosis and antineutrophil cytoplasmic autoantibodies.
Granulomatosis with Polyangiitis
Wegener's granulomatosis associated with renal cell carcinoma.
Granulomatosis with Polyangiitis
Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase.
Granulomatosis with Polyangiitis
Wegener's granulomatosis presenting as pyoderma gangrenosum.
Granulomatosis with Polyangiitis
Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response.
Granulomatosis with Polyangiitis
Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation.
Granulomatosis with Polyangiitis
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
Granulomatosis with Polyangiitis
What you should know about PR3-ANCA. Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA.
Granulomatosis with Polyangiitis
When a wound is the harbinger of a serious underlying systemic illness.
Granulomatosis with Polyangiitis
[A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]
Granulomatosis with Polyangiitis
[A case of Wegener's granulomatosis with episcleritis, mediastinal lesions, and pleural effusion and without serum anti-neutrophil cytoplasmic antibodies]
Granulomatosis with Polyangiitis
[A case of Wegener's granulomatosis with orbital inflammatory pseudotumor]
Granulomatosis with Polyangiitis
[Anti-neutrophil cytoplasmic autoantibody (ANCA) in systemic vasculitic syndrome]
Granulomatosis with Polyangiitis
[Antineutrophilic cytoplasmic antibodies (ANCA) in inflammatory rheumatic diseases: immunodiagnostic and immunopathogenetic aspects]
Granulomatosis with Polyangiitis
[Atypical location of Wegener's granulomatosis with breast involvement: case report].
Granulomatosis with Polyangiitis
[B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis : Origin of anti-neutrophil cytoplasmic antibody formation?]
Granulomatosis with Polyangiitis
[Clinical and pathogenetic aspects of kidney damage associated with neutrophilic cytoplasm antibodies]
Granulomatosis with Polyangiitis
[Distribution pattern of proteinase 3 in Wegener's granulomatosis and other vasculitic diseases]
Granulomatosis with Polyangiitis
[New aspects of antineutrophil cytoplasmic antibody (ANCA) diagnosis in vasculitis]
Granulomatosis with Polyangiitis
[New aspects of the pathogenesis of gout : Danger signals, autoinflammation and beyond.]
Granulomatosis with Polyangiitis
[Subglottal stenosis as the first symptom of Wegener's granulomatosis]
Granulomatosis with Polyangiitis
[The clinical analysis of 46 cases with antineutrophil cytoplasmic antibody-associated vasculitis].
Granulomatosis with Polyangiitis
[The complement system in the pathogenesis of antineutrophil cytoplasm antibodies-associated vasculitis].
Graves Disease
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Graves Disease
Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.
Hearing Loss
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Hearing Loss
Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.
Hearing Loss
[Wegener's granulomatosis (WG) presented with hearing loss and without positive serologic ANCA]
Hearing Loss, Sensorineural
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Hematuria
Carbimazole-Induced, ANCA-Associated, Crescentic Glomerulonephritis: Case Report and Literature Review.
Hematuria
Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis.
Hematuria
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Hemoglobinuria
Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria
Proteinase 3 expression on the neutrophils of patients with paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria, Paroxysmal
Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria, Paroxysmal
Proteinase 3 expression on the neutrophils of patients with paroxysmal nocturnal hemoglobinuria.
Hepatitis
Severe ductopenia and cholestasis from levofloxacin drug-induced liver injury: a case report and review.
Hepatitis B, Chronic
Antineutrophil cytoplasmic antibodies (ANCA)-positive patient with infective endocarditis and chronic hepatitis B virus: a case report and review of the literature.
Hepatitis C
A rare and severe cutaneous adverse effect of telaprevir: drug rash with eosinophilia and systemic symptoms.
Hepatitis C
Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection.
Hepatitis, Autoimmune
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Hypergammaglobulinemia
Clinically-irrelevant positivity for serum proteinase 3-ANCA in HIV disease.
Hyperglycemia
Comprehensive transcriptome analysis of colorectal cancer risk of hyperglycemia in humans.
Hyperthyroidism
Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA.
Hyperthyroidism
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Idiopathic Interstitial Pneumonias
2020 international consensus on ANCA testing beyond systemic vasculitis.
Infections
Corynebacterium jeikeium pacemaker infection associated with antineutrophil cytoplasmic antibodies: a single positive blood culture could be sufficient for diagnosis.
Infections
Immunological interactions of Chilo suppressalis Walker (Lepidoptera: Crambidae) with the native entomopathogenic fungi.
Infections
Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice.
Infections
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Infections
LTF, PRTN3, and MNDA in Synovial Fluid as Promising Biomarkers for Periprosthetic Joint Infection: Identification by Quadrupole Orbital-Trap Mass Spectrometry.
Infections
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
Infections
NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1? processing during Streptococcus pneumoniae infection.
Infections
Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
Infections
Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches.
Infections
Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection.
Infections
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Infections
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection.
Infections
The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.
Infections
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Infertility
Malignant Pyoderma Associated with Granulomatosis with Polyangiitis (Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I.
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study.
Inflammatory Bowel Diseases
Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease and Collagenous Colitis: No Association with Lactoferrin, ?-Glucuronidase, Myeloperoxidase, or Proteinase 3.
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases.
Inflammatory Bowel Diseases
Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease.
Inflammatory Bowel Diseases
PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC).
Inflammatory Bowel Diseases
The diagnostic role and clinical association of serum proteinase 3 anti-neutrophil cytoplasmic antibodies in Chinese patients with inflammatory bowel disease.
Influenza, Human
Critical Role of SerpinB1 in Regulating Inflammatory Responses in Pulmonary Influenza Infection.
Influenza, Human
Viral RNA in the influenza vaccine may have contributed to the development of ANCA-associated vasculitis in a patient following immunisation.
Insulin Resistance
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Intestinal Diseases
Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease.
Kidney Failure, Chronic
Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
Kidney Failure, Chronic
De novo glomerulonephritis in patients during remission from Wegener's granulomatosis.
Kidney Failure, Chronic
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Kidney Failure, Chronic
Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study.
Latent Tuberculosis
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
Leukemia
Arsenic trioxide augments all-trans retinoic acid-induced differentiation of HL-60 cells.
Leukemia
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Leukemia
Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3.
Leukemia
Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.
Leukemia
Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells.
Leukemia
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units.
Leukemia
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
Leukemia
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
Leukemia
Functional interactions between bile acids, all-trans retinoic acid, and 1,25-dihydroxy-vitamin D3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells.
Leukemia
Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells.
Leukemia
Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid.
Leukemia
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Leukemia
Proteinase 3 (PR3) gene is highly expressed in CBF leukemias and codes for a protein with abnormal nuclear localization that confers drug sensitivity.
Leukemia
Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.
Leukemia
Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid.
Leukemia
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
Leukemia
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells.
Leukemia
WITHDRAWN: Proteinase 3 (PR3) gene is highly expressed in CBF leukemias and codes for a protein with abnormal nuclear localization that confers drug sensitivity.
Leukemia, Lymphoid
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells.
Leukemia, Myeloid
A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia.
Leukemia, Myeloid
An anti-PR1/HLA-A2 T cell receptor-like antibody mediates complement dependent cytotoxicity against acute myeloid leukemia progenitor cells.
Leukemia, Myeloid
Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice.
Leukemia, Myeloid
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
Leukemia, Myeloid
Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase.
Leukemia, Myeloid
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Leukemia, Myeloid
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy.
Leukemia, Myeloid
Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid.
Leukemia, Myeloid
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Leukemia, Myeloid
Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.
Leukemia, Myeloid
Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid.
Leukemia, Myeloid
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells.
Leukemia, Myeloid
The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1.
Leukemia, Myeloid, Acute
A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells.
Leukemia, Myeloid, Acute
Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo.
Leukemia, Myeloid, Acute
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation.
Leukemia, Myeloid, Acute
Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909.
Liver Diseases
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Liver Diseases
Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis.
Liver Diseases
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Liver Diseases
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Liver Diseases
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Lung Diseases
A case of proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) positive/IgG4-related lung disease.
Lung Diseases
Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.
Lung Diseases
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
Lung Diseases
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Lung Diseases
Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases.
Lung Diseases
Sjögren's syndrome, cavitating lung disease and high sustained levels of antibodies to serine proteinase 3.
Lung Diseases, Interstitial
Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
Lung Diseases, Interstitial
The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies.
Lung Diseases, Interstitial
Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3.
Lung Neoplasms
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Lupus Erythematosus, Systemic
Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Case of systemic lupus erythematosus with strong proteinase 3 antineutrophil cytoplasmic antibody positivity.
Lupus Erythematosus, Systemic
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Lupus Erythematosus, Systemic
Immunologic markers for differentiation of autoimmune responses.
Lupus Erythematosus, Systemic
[New aspects of the pathogenesis of gout : Danger signals, autoinflammation and beyond.]
Lupus Nephritis
ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis.
Lupus Nephritis
Differences in clinico-pathological characteristics and outcomes between proteinase 3-ANCA positivity and myeloperoxidase-ANCA positivity in lupus nephritis.
Lymphoma
Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
Lymphoma, B-Cell
Cross Talk Between TGF-? and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy.
Lymphoma, B-Cell
Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway.
Lymphoma, B-Cell
Effect of miR-26a on diabetic rats with myocardial injury by targeting PTEN.
Lymphoma, B-Cell
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
Lymphoma, B-Cell
Inhibition of Wnt3a/FOXM1/?-Catenin Axis and Activation of GSK3? and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers.
Lymphoma, B-Cell
Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice.
Lymphoma, B-Cell
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Lymphoma, B-Cell
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway.
Lymphoma, B-Cell
Remifentanil protects neurological function of rats with cerebral ischemia-reperfusion injury via NR2B/CaMKII? signaling pathway.
Mastitis
Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.
Maxillary Sinusitis
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Melanoma
Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens.
Meningitis
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Microscopic Polyangiitis
A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis.
Microscopic Polyangiitis
Advances in pathogenesis and treatment of ANCA-associated vasculitis.
Microscopic Polyangiitis
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.
Microscopic Polyangiitis
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Microscopic Polyangiitis
Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis.
Microscopic Polyangiitis
Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?
Microscopic Polyangiitis
Clinical and prognostic features of Korean patients with MPO-ANCA, PR3-ANCA and ANCA-negative vasculitis.
Microscopic Polyangiitis
Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan otological society.
Microscopic Polyangiitis
Determination of anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: Comparative analysis of different strategies.
Microscopic Polyangiitis
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Microscopic Polyangiitis
Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA.
Microscopic Polyangiitis
Epitope-specific anti-neutrophil cytoplasmic antibodies: do they matter? Can they be detected?
Microscopic Polyangiitis
Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis.
Microscopic Polyangiitis
Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis.
Microscopic Polyangiitis
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.
Microscopic Polyangiitis
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.
Microscopic Polyangiitis
Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study.
Microscopic Polyangiitis
Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides.
Microscopic Polyangiitis
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Microscopic Polyangiitis
Myeloperoxidase-ANCA-Positive and ANCA-Negative Patients With Granulomatosis With Polyangiitis: Distinct Patient Subsets.
Microscopic Polyangiitis
Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China.
Microscopic Polyangiitis
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Microscopic Polyangiitis
Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention.
Microscopic Polyangiitis
Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Microscopic Polyangiitis
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Microscopic Polyangiitis
Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction.
Microscopic Polyangiitis
Proposal for a more practical classification of antineutrophil cytoplasmic antibody-associated vasculitis.
Microscopic Polyangiitis
Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener's granulomatosis.
Microscopic Polyangiitis
The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies.
Microscopic Polyangiitis
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Microscopic Polyangiitis
Unusually indolent MPO-ANCA: associated vasculitis-report of two cases.
Microscopic Polyangiitis
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
Microscopic Polyangiitis
[Antineutrophilic cytoplasmic antibodies (ANCA) in inflammatory rheumatic diseases: immunodiagnostic and immunopathogenetic aspects]
Microscopic Polyangiitis
[New aspects of antineutrophil cytoplasmic antibody (ANCA) diagnosis in vasculitis]
Microscopic Polyangiitis
[The clinical analysis of 46 cases with antineutrophil cytoplasmic antibody-associated vasculitis].
Microscopic Polyangiitis
[The complement system in the pathogenesis of antineutrophil cytoplasm antibodies-associated vasculitis].
Mixed Connective Tissue Disease
Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.
Mixed Connective Tissue Disease
[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
Mononeuropathies
Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis.
Multiple Myeloma
A Case Report of Multiple Myeloma Associated With Myeloperoxidase and Proteinase-3 Antibodies Posing a Diagnostic Dilemma.
Muscular Dystrophies, Limb-Girdle
Prenatal diagnosis of limb-girdle muscular dystrophy type 2A.
myeloblastin deficiency
Characterization of neutrophil function in Papillon-Lefèvre syndrome.
Myocardial Infarction
Proteinase 3 and prognosis of patients with acute myocardial infarction.
Neoplasm Metastasis
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Neoplasm Metastasis
Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Neoplasm, Residual
Inflammation and cancer: inhibiting the progression of residual hepatic VX2 carcinoma by anti-inflammatory drug after incomplete radiofrequency ablation.
Neoplasms
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins.
Neoplasms
Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo.
Neoplasms
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Neoplasms
Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent.
Neoplasms
Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.
Neoplasms
Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3.
Neoplasms
Cross Talk Between TGF-? and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy.
Neoplasms
De novo synthesis of proteinase 3 by cytokine primed circulating human polymorphonuclear neutrophils and mononuclear cells.
Neoplasms
Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.
Neoplasms
Expression of myeloperoxidase (MPO) by neutrophils is necessary for their activation by anti-neutrophil cytoplasm autoantibodies (ANCA) against MPO.
Neoplasms
Febrile temperatures control antineutrophil cytoplasmic autoantibody-induced neutrophil activation via inhibition of phosphatidylinositol 3-kinase/Akt.
Neoplasms
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
Neoplasms
In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment.
Neoplasms
Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Neoplasms
Low P4HA2 and high PRTN3 expression predicts poor survival in patients with pancreatic cancer.
Neoplasms
MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers.
Neoplasms
Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation.
Neoplasms
Sex differences in inflammatory and apoptotic signaling molecules in normal and diseased human gingiva.
Neoplasms
Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.
Neoplasms
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer.
Neoplasms
Translational mini-review series on vaccines: Peptide vaccines for myeloid leukaemias.
Neoplasms
Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3.
Neoplasms
Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.
Neoplasms
Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients.
Nephritis
A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis.
Nephritis
Antimyeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis.
Nephritis
Antineutrophil cytoplasmic autoantibody specific for proteinase 3 in a patient with shunt nephritis induced by Gemella morbillorum.
Nephritis, Interstitial
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review.
Nephritis, Interstitial
Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA.
Non-alcoholic Fatty Liver Disease
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Non-alcoholic Fatty Liver Disease
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Non-alcoholic Fatty Liver Disease
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Osteoarthritis, Knee
[Effects of sand treatment in uyghur medicine on caspse-3, Bcl-2, Bax, and the apoptotic expression in the cartilage of rabbit knee osteoarthritis model].
Otitis
Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis.
Otitis Media
Bilateral Facial Nerve Palsy due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody.
Otitis Media
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Otitis Media
Intractable Otitis Media Presenting as Falsely Positive for Proteinase 3-ANCA: A Case Report.
Otitis Media with Effusion
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Pancreatic Neoplasms
Low P4HA2 and high PRTN3 expression predicts poor survival in patients with pancreatic cancer.
Pancreatitis
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Papilloma, Inverted
[The expression and significance of smac, XIAP, caspase-3 in nonasal inverted papilloma].
Peri-Implantitis
Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
Periodontal Diseases
Are proteinase 3 and cathepsin C enzymes related to pathogenesis of periodontitis?
Periodontal Diseases
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Periodontitis
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Periodontitis
Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.
Periodontitis
Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2.
Peripheral Nervous System Diseases
The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Peripheral Nervous System Diseases
Wegener's granulomatosis of the penis: genital presentation of systemic disease.
Peritonitis
Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pneumonia
Diagnostic value of antineutrophil cytoplasmic antibodies in children with bronchiolitis obliterans.
Pneumonia
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
Polyarteritis Nodosa
Anti-neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa.
Polyarteritis Nodosa
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Prostatic Neoplasms
Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Proteinuria
Carbimazole-Induced, ANCA-Associated, Crescentic Glomerulonephritis: Case Report and Literature Review.
Proteinuria
Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats.
Proteinuria
Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis.
Proteinuria
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Proteinuria
Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.
Proteinuria
[Severe chronic headache with depression induced by pachymeningitis in Wegener's granulomatosis]
Pseudomonas Infections
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection.
Pulmonary Disease, Chronic Obstructive
?-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
A specific proteinase 3 activity footprint in ?1-antitrypsin deficiency.
Pulmonary Disease, Chronic Obstructive
Characterizing the Dynamics and Ligand-Specific Interactions in the Human Leukocyte Elastase through Molecular Dynamics Simulations.
Pulmonary Disease, Chronic Obstructive
Dissociation between airway and systemic autoantibody responses in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Elastolysis by proteinase 3 and its inhibition by alpha(1)-proteinase inhibitor: a mechanism for the incomplete inhibition of ongoing elastolysis.
Pulmonary Disease, Chronic Obstructive
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Pulmonary Disease, Chronic Obstructive
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD.
Pulmonary Disease, Chronic Obstructive
Proteinase 3 Activity in sputum from subjects with Alpha-1-Antitrypsin deficiency and COPD.
Pulmonary Disease, Chronic Obstructive
Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.
Pulmonary Disease, Chronic Obstructive
Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort.
Pulmonary Disease, Chronic Obstructive
The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases.
Pulmonary Edema
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Pulmonary Emphysema
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis.
Pulmonary Emphysema
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA).
Purpura
Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA.
Purpura
[Difficulties in the differential diagnosis of kidney injury in a patient with infective endocarditis associated with antineutrophil cytoplasmic antibodies].
Pyoderma
[Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].
Renal Insufficiency
Aneurysmal subarachnoid hemorrhage in a patient with Wegener's granulomatosis.
Renal Insufficiency
Mizoribine as a safe and effective combined maintenance therapy with prednisolone for anti-neutrophil cytoplasmic antibody-associated vasculitis in a hemodialysis patient.
Renal Insufficiency
[Severe chronic headache with depression induced by pachymeningitis in Wegener's granulomatosis]
Respiratory Distress Syndrome
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Retinoblastoma
Perspectives on signaling for biological- and processed food-related advanced glycation end-products and its role in cancer progression.
Scleritis
Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region.
Scleritis
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Scleritis
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Scleroderma, Diffuse
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Scleroderma, Systemic
Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis.
Scleroderma, Systemic
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Sepsis
Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.
Sepsis
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Sepsis
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Sepsis
Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis.
Sepsis
Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients.
Sepsis
Time Series Gene Expression Profiles Analysis Identified Several Potential Biomarkers for Sepsis.
Severe Acute Respiratory Syndrome
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Shock, Septic
Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.
Sinusitis
Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis.
Sinusitis
Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis.
Sjogren's Syndrome
Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer.
Spondylitis, Ankylosing
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Stomach Neoplasms
Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer.
Stomach Neoplasms
Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer.
Synovitis
Antineutrophil cytoplasmic antibodies in synovial fluid and in serum of patients with rheumatoid arthritis and other types of synovitis.
Systemic Vasculitis
alpha 1-Antitrypsin (AAT) deficiency and ANCA-positive systemic vasculitis: genetic and clinical implications.
Systemic Vasculitis
Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis.
Systemic Vasculitis
Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens.
Systemic Vasculitis
Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site.
Systemic Vasculitis
Anti-neutrophil cytoplasmic antibodies in generalized autoimmune diseases.
Systemic Vasculitis
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders.
Systemic Vasculitis
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Systemic Vasculitis
Antigen specificities and clinical distribution of ANCA in kidney diseases.
Systemic Vasculitis
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
Systemic Vasculitis
Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells.
Systemic Vasculitis
Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall.
Systemic Vasculitis
Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils.
Systemic Vasculitis
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Systemic Vasculitis
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.
Systemic Vasculitis
Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression.
Systemic Vasculitis
Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase.
Systemic Vasculitis
Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission.
Systemic Vasculitis
Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.
Systemic Vasculitis
Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
Systemic Vasculitis
No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
Systemic Vasculitis
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Systemic Vasculitis
Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis.
Systemic Vasculitis
Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction.
Systemic Vasculitis
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Systemic Vasculitis
Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.
Systemic Vasculitis
Proteinase-3 antineutrophil cytoplasm antibody positivity in patients without primary systemic vasculitis.
Systemic Vasculitis
Pulmonary-renal vasculitic disorders: differential diagnosis and management.
Systemic Vasculitis
Recombinant protein to analyze autoantibodies to proteinase 3 in systemic vasculitis.
Systemic Vasculitis
Renal Survival in Proteinase 3 and Myeloperoxidase ANCA-Associated Systemic Vasculitis.
Systemic Vasculitis
Review article: The role of CD4(+) T cells in ANCA-associated systemic vasculitis.
Systemic Vasculitis
S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.
Systemic Vasculitis
Significance of autoantibodies to purified proteinase 3 in systemic vasculitis.
Systemic Vasculitis
T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis.
Systemic Vasculitis
T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission.
Systemic Vasculitis
Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population.
Systemic Vasculitis
Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.
Systemic Vasculitis
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
Systemic Vasculitis
[Anti-cytoplasmic antibodies of polynucle or "ANCA". A new class of autoantibodies]
Systemic Vasculitis
[Antibodies to proteinase-3 and myeloperoxidase in systemic vasculitis]
Systemic Vasculitis
[B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis : Origin of anti-neutrophil cytoplasmic antibody formation?]
Systemic Vasculitis
[Wegener's granulomatosis and ANCA-associated vasculitis: pathogenic role of autoantigens, autoantibodies, and cytokines]
Thyroid Diseases
Association between thyroid disease and its treatment with ANCA small-vessel vasculitis: a case-control study.
Tuberculosis
Low seroprevalence and poor specificity of antineutrophil cytoplasmic antibodies in tuberculosis.
Urinary Bladder Neoplasms
Analytical Performance of ELISA Assays in Urine: One More Bottleneck towards Biomarker Validation and Clinical Implementation.
Vascular Diseases
Antibodies with dual reactivity to plasminogen and complementary PR3 in PR3-ANCA vasculitis.
Vascular Diseases
Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.
Vascular System Injuries
Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens.
Vascular System Injuries
Wegener's granulomatosis--autoimmunity to neutrophil proteinase 3.
Vasculitis
-463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis.
Vasculitis
4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis.
Vasculitis
A case series and literature review on patients with rhinological complications secondary to the use of cocaine and levamisole.
Vasculitis
A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis.
Vasculitis
A myelopoiesis gene signature during remission in anti-neutrophil cytoplasm antibody-associated vasculitis does not predict relapses but seems to reflect ongoing prednisolone therapy.
Vasculitis
A novel capture-ELISA for detection of anti-neutrophil cytoplasmic antibodies (ANCA) based on c-myc peptide recognition in carboxy-terminally tagged recombinant neutrophil serine proteases.
Vasculitis
A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis.
Vasculitis
A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis.
Vasculitis
Aggregatibacter aphrophilus infective endocarditis confirmed by broad-range PCR diagnosis: A case report.
Vasculitis
Alterations of serum levels of plasminogen, TNF-?, and IDO in granulomatosis with polyangiitis patients.
Vasculitis
An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report.
Vasculitis
Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects.
Vasculitis
Analysis of T-cell receptor usage in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
Vasculitis
ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells.
Vasculitis
ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation.
Vasculitis
ANCA positive crescentic glomerulonephritis outcome in a Central East European cohort: a retrospective study.
Vasculitis
ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?
Vasculitis
Anti-glomerular basement membrane (anti-GBM) disease accompanied by vasculitis that was not positive for antineutrophil cytoplasmic antibodies to myeloperoxidase and proteinase 3: a report of two cases and the incidence of anti-GBM disease at one institution.
Vasculitis
Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development.
Vasculitis
Anti-myeloperoxidase antibodies enhance phagocytosis, IL-8 production, and glucose uptake of polymorphonuclear neutrophils rather than anti-proteinase 3 antibodies leading to activation-induced cell death of the neutrophils.
Vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis.
Vasculitis
Anti-neutrophil cytoplasmic antibody-associated vasculitis, large vessel vasculitis and kawasaki disease in Japan.
Vasculitis
Anti-neutrophil cytoplasmic autoantibodies and leukocyte-endothelial interactions: a sticky connection?
Vasculitis
Anti-neutrophil cytoplasmic autoantibody pathogenicity revisited: pathogenic versus non-pathogenic anti-neutrophil cytoplasmic autoantibody.
Vasculitis
Anti-oxidized low-density lipoprotein antibodies in myeloperoxidase-positive vasculitis patients preferentially recognize hypochlorite-modified low density lipoproteins.
Vasculitis
Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells.
Vasculitis
Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1).
Vasculitis
Antigen-specific ANCA ELISAs have different sensitivities for active and treated vasculitis and for nonvasculitic disease.
Vasculitis
Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease.
Vasculitis
Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.
Vasculitis
Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis.
Vasculitis
Antineutrophil cytoplasmic antibody (ANCA) vasculitis: pathophysiology, diagnosis, and the evolving treatment landscape.
Vasculitis
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Vasculitis
Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease.
Vasculitis
Association of Cigarette Smoking With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Vasculitis
Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
Vasculitis
Bilateral Facial Nerve Palsy due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody.
Vasculitis
C3 and C4 allotypes in anti-neutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis.
Vasculitis
Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis.
Vasculitis
Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis.
Vasculitis
Clinical characteristics of patients with vasculitis positive for anti-neutrophil cytoplasmic antibody targeting both proteinase 3 and myeloperoxidase: a retrospective study.
Vasculitis
Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis.
Vasculitis
Comparative evaluation of unfixed and fixed human neutrophils for determination of antineutrophil cytoplasmic antibodies by indirect immunofluorescence.
Vasculitis
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
Vasculitis
Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.
Vasculitis
Difference in relapse-rate and clinical phenotype by autoantibody-subtype in Japanese patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
Vasculitis
Differences between myeloperoxidase-antineutrophil cytoplasmic autoantibody (ANCA) and proteinase 3-ANCA associated vasculitis: A retrospective study from a single center in China.
Vasculitis
Discrepancies between two immunoassays for the determination of MPO and PR3 autoantibodies.
Vasculitis
Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.
Vasculitis
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Vasculitis
Dysregulation of autoantigen genes in ANCA-associated vasculitis involves alternative transcripts and new protein synthesis.
Vasculitis
Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies.
Vasculitis
Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins.
Vasculitis
Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis.
Vasculitis
Epitope-specific anti-neutrophil cytoplasmic antibodies: do they matter? Can they be detected?
Vasculitis
Escherichia coli and Proteus mirabilis inhibit the perinuclear but not the circulating antineutrophil cytoplasmic antibody reaction.
Vasculitis
Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis.
Vasculitis
Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial.
Vasculitis
Frequency of anti-bactericidal/permeability-increasing protein (BPI) and anti-azurocidin in patients with renal disease.
Vasculitis
Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.
Vasculitis
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis.
Vasculitis
High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy.
Vasculitis
Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
Vasculitis
Hydralazine induces myeloperoxidase and proteinase 3 anti-neutrophil cytoplasmic antibody vasculitis and leads to pulmonary renal syndrome.
Vasculitis
Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls.
Vasculitis
Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration.
Vasculitis
Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis.
Vasculitis
Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression.
Vasculitis
In silico design, synthesis, and assays of specific substrates for proteinase 3: influence of fluorogenic and charged groups.
Vasculitis
In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase.
Vasculitis
Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission.
Vasculitis
Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti proteinase 3 antibodies.
Vasculitis
Increased monocyte transcription of the proteinase 3 gene in small vessel vasculitis.
Vasculitis
Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.
Vasculitis
Indirect immunofluorescence (IIF) of normal washed peripheral blood cells to demonstrate antineutrophil cytoplasmic antibodies (ANCA).
Vasculitis
Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils.
Vasculitis
Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils.
Vasculitis
Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis?
Vasculitis
Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.
Vasculitis
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.
Vasculitis
Measuring circulating complement activation products in myeloperoxidase and proteinase 3 antineutrophil cytoplasmic antibody vasculitis.
Vasculitis
Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis.
Vasculitis
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Vasculitis
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Vasculitis
Mizoribine as a safe and effective combined maintenance therapy with prednisolone for anti-neutrophil cytoplasmic antibody-associated vasculitis in a hemodialysis patient.
Vasculitis
Monitoring proteinase 3 antineutrophil cytoplasmic antibodies for detection of relapses in small vessel vasculitis.
Vasculitis
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Vasculitis
Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis.
Vasculitis
Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation.
Vasculitis
Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.
Vasculitis
Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.
Vasculitis
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Vasculitis
New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.
Vasculitis
Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene.
Vasculitis
p-ANCA with myeloperoxidase antibodies and c-ANCA with proteinase 3 antibodies define a different vasculitis entity in patients with renal involvement.
Vasculitis
Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Vasculitis
Performance evaluation of three assays for the detection of PR3-ANCA in granulomatosis with polyangiitis in daily practice.
Vasculitis
Positive classic antineutrophil cytoplasmic antibody (C-ANCA) titer at switch to azathioprine therapy associated with relapse in proteinase 3-related vasculitis.
Vasculitis
Post-infectious acute glomerulonephritis with vasculitis and pulmonary hemorrhage.
Vasculitis
PR3 antibodies do not induce renal pathology in a novel PR3-humanized mouse model for Wegener's granulomatosis.
Vasculitis
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Vasculitis
Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.
Vasculitis
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
Vasculitis
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.
Vasculitis
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.
Vasculitis
Re-evaluation of 129 patients with systemic necrotizing vasculitides by using classification algorithm according to consensus methodology.
Vasculitis
Reactivity against Complementary Proteinase-3 Is Not Increased in Patients with PR3-ANCA-Associated Vasculitis.
Vasculitis
Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: subversion towards autoimmunity by proteinase 3.
Vasculitis
Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice.
Vasculitis
Review article: The role of CD4(+) T cells in ANCA-associated systemic vasculitis.
Vasculitis
Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's).
Vasculitis
S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.
Vasculitis
Saint John on Patmos: Revelations of the Role of Antineutrophil Cytoplasmic Antibody (ANCA) in Vasculitis.
Vasculitis
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA).
Vasculitis
Should proteinase 3 and myeloperoxidase antineutrophil cytoplasmic antibody vasculitis be treated differently: part 1.
Vasculitis
Should proteinase-3 and myeloperoxidase-anti-neutrophil cytoplasmic antibody vasculitis be treated differently: part 2.
Vasculitis
Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.
Vasculitis
Structure of the azurocidin, proteinase 3, and neutrophil elastase genes. Implications for inflammation and vasculitis.
Vasculitis
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Vasculitis
Surgical Treatment of Symptomatic Aortic Aneurysm in a Patient with Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: Case Report and Review of the Literature.
Vasculitis
The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558.
Vasculitis
The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction.
Vasculitis
Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
Vasculitis
Treatment with the purine synthesis inhibitor mizoribine for ANCA-associated renal vasculitis.
Vasculitis
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Vasculitis
Twenty-eight years with antineutrophil cytoplasmic antibodies (ANCA): how to test for ANCA - evidence-based immunology?
Vasculitis
Urinary CD4+ effector memory T cells reflect renal disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.
Vasculitis
Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.
Vasculitis
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Vasculitis
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.
Vasculitis
[Antineutrophil cytoplasmic antibodies in nonvasculitis diseases: clinical correlates and target antigens]
Vasculitis
[Antineutrophilic cytoplasmic antibodies (ANCA) in inflammatory rheumatic diseases: immunodiagnostic and immunopathogenetic aspects]
Vasculitis
[Clinical and pathogenetic aspects of kidney damage associated with neutrophilic cytoplasm antibodies]
Vasculitis
[Review article: Antineutrophil cytoplasmic antibody in small vessel vasculitis]
Vasculitis
[The complement system in the pathogenesis of antineutrophil cytoplasm antibodies-associated vasculitis].
Vasculitis
[Wegener's granulomatosis with anti-neutrophil cytoplasmic antibodies against anti-cathepsin G antigen.]
Vasculitis, Leukocytoclastic, Cutaneous
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Virus Diseases
Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall.
Wilms Tumor
Anti-leukemia T cells in AML: TNF-?(+) CD8(+) T cells may escape detection and possibly reflect a stage of functional impairment.
Wilms Tumor
Cancer vaccines for patients with acute myeloid leukemia--definition of leukemia-associated antigens and current clinical protocols targeting these antigens.
Wilms Tumor
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Wilms Tumor
Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens.
Wilms Tumor
Longitudinal analyses of leukemia-associated antigen-specific CD8(+) T cells in patients after allogeneic stem cell transplantation.
Wilms Tumor
Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909.
Wilms Tumor
Translational mini-review series on vaccines: Peptide vaccines for myeloid leukaemias.
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