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Disease on EC 3.4.21.76 - Myeloblastin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Discrepancies between two immunoassays for the determination of MPO and PR3 autoantibodies.
Acute Kidney Injury
Aggregatibacter aphrophilus infective endocarditis confirmed by broad-range PCR diagnosis: A case report.
Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis.
Proliferative glomerulonephritis and mantle cell lymphoma: a rare association.
Acute Lung Injury
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Adenocarcinoma of Lung
KRAS mutation is associated with elevated myeloblastin activity in human lung adenocarcinoma.
Agranulocytosis
Cocaine-Induced Vasculitis.
Alzheimer Disease
[Effect of Active Ingredients of Qingxin Kaiqiao Recipe on Spatial Learning and Memory Capacities, and Expressions of Bax, Bcl-2, Caspase-3, and PAPP in Hippocampus of AD Model Rats].
Anemia
[Antineutrophil cytoplasmic antibodies in patients with sickle cell anemia]
[Difficulties in the differential diagnosis of kidney injury in a patient with infective endocarditis associated with antineutrophil cytoplasmic antibodies].
Anemia, Sickle Cell
[Antineutrophil cytoplasmic antibodies in patients with sickle cell anemia]
Anti-Glomerular Basement Membrane Disease
2020 international consensus on ANCA testing beyond systemic vasculitis.
Anti-glomerular basement membrane (anti-GBM) disease accompanied by vasculitis that was not positive for antineutrophil cytoplasmic antibodies to myeloperoxidase and proteinase 3: a report of two cases and the incidence of anti-GBM disease at one institution.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
2020 international consensus on ANCA testing beyond systemic vasculitis.
Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo.
Alpha 1-antitrypsin activity is markedly decreased in Wegener's granulomatosis.
An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report.
ANCA as a Predictor of Relapse: Useful in Patients with Renal Involvement But Not in Patients with Nonrenal Disease.
ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives.
Anti-neutrophil Cytoplasmic Antibodies (ANCA) as Disease Activity Biomarkers in a "Personalized Medicine Approach" in ANCA-Associated Vasculitis.
Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.
Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3 in ANCA-Associated Vasculitis.
Comparison of enzyme-linked immunosorbent assay and rapid chemiluminescent analyser in the detection of myeloperoxidase and proteinase 3 autoantibodies.
Diagnostic ANCA algorithms in daily clinical practice: evidence, experience, and effectiveness.
Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis.
Endothelial tissue factor stimulation by proteinase 3 and elastase.
Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis.
Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial.
Factors Determining the Clinical Utility of Serial Measurements of Antineutrophil Cytoplasmic Antibodies Targeting Proteinase 3.
Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis.
IgA- and SIgA anti-PR3 antibodies in serum versus organ involvement and disease activity in PR3-ANCA associated vasculitis.
Immunoglobulins G from patients with ANCA-associated vasculitis are atypically glycosylated in both the Fc and Fab regions and the relation to disease activity.
Lupus nephritis and ANCA-associated vasculitis: towards precision medicine?
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.
Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.
No association of G-463A myeloperoxidase gene polymorphism with MPO-ANCA-associated vasculitis.
Off balance: T-cells in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis: challenges and solutions 2014.
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.
Serial ANCA titers: useful tool for prevention of relapses in ANCA-associated vasculitis.
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.
The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies.
The Diagnostic and Clinical Utility of Autoantibodies in Systemic Vasculitis.
The role of myeloperoxidase in the pathogenesis of systemic vasculitis.
What you should know about PR3-ANCA. Evidence for the role of T cells in the pathogenesis of systemic vasculitis.
[ANCA diagnostics in vasculitis].
Antiphospholipid Syndrome
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Arteritis
A case of PR3-ANCA-positive anti-GBM disease associated with intrarenal arteritis and thrombotic microangiopathy.
Arthralgia
A case series and literature review on patients with rhinological complications secondary to the use of cocaine and levamisole.
Cocaine-Induced Vasculitis.
Arthritis
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Eosinophilia in Wegener's granulomatosis.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis.
Wegener's granulomatosis of the penis: genital presentation of systemic disease.
Arthritis, Reactive
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Arthritis, Rheumatoid
A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis.
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis.
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta.
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
The membrane proteinase 3 expression on neutrophils was downregulated after treatment with infliximab in patients with rheumatoid arthritis.
Asthma
[The Churg-Strauss syndrome]
Atherosclerosis
Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.
Autoimmune Diseases
Analysis of a biomarker for Wegener's granulomatosis.
ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation.
Antibodies to proteinase 3 prime human oral, lung, and kidney epithelial cells to secrete proinflammatory cytokines upon stimulation with agonists to various Toll-like receptors, NOD1, and NOD2.
Antineutrophil cytoplasmic antibody (ANCA) vasculitis: pathophysiology, diagnosis, and the evolving treatment landscape.
Characterization of the CD177 interaction with the ANCA antigen proteinase 3.
Discrepancies between two immunoassays for the determination of MPO and PR3 autoantibodies.
Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies.
Immunologic markers for differentiation of autoimmune responses.
Impact of autoantibody glycosylation in autoimmune diseases.
Protein microarrays with carbon nanotubes as multicolor Raman labels.
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Blast Crisis
Chronic myeloid leukemia cells express tumor-associated antigens eliciting specific CD8+ T-cell responses and are lacking costimulatory molecules.
The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia.
Bone Diseases
Dietary modulation of the microbiome affects autoinflammatory disease.
Breast Neoplasms
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1.
Impact of cyclins E, neutrophil elastase and proteinase 3 expression levels on clinical outcome in primary breast cancer patients.
Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
Bronchiectasis
Phase 2 Trial of the DPP-1 Inhibitor Brensocatib in Bronchiectasis.
Bronchitis, Chronic
Proteinase 3 Activity in sputum from subjects with Alpha-1-Antitrypsin deficiency and COPD.
Carcinogenesis
Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.
[The expression and significance of smac, XIAP, caspase-3 in nonasal inverted papilloma].
Carcinoma
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression.
[A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]
Carcinoma, Renal Cell
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression.
[A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]
Cerebral Infarction
Remifentanil protects neurological function of rats with cerebral ischemia-reperfusion injury via NR2B/CaMKII? signaling pathway.
Cholangiocarcinoma
Anti-glycoprotein 2 (anti-GP2) IgA and anti-neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3-ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis.
Cholangitis, Sclerosing
Anti-glycoprotein 2 (anti-GP2) IgA and anti-neutrophil cytoplasmic antibodies to serine proteinase 3 (PR3-ANCA): antibodies to predict severe disease, poor survival and cholangiocarcinoma in primary sclerosing cholangitis.
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Chronic Periodontitis
Protease-activated receptor-2 (PAR(2)) in human periodontitis.
Churg-Strauss Syndrome
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Autoantibodies in vasculitis.
Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis.
Determination of anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: Comparative analysis of different strategies.
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS).
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Pathophysiology of ANCA-associated small vessel vasculitis.
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction.
Re-evaluation of 129 patients with systemic necrotizing vasculitides by using classification algorithm according to consensus methodology.
Systemic necrotizing vasculitis.
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
[Classification of systemic vasculatides]
[Microscopic polyangiitis]
Colitis
Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.
Colitis, Collagenous
Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease and Collagenous Colitis: No Association with Lactoferrin, ?-Glucuronidase, Myeloperoxidase, or Proteinase 3.
Colitis, Ulcerative
A subset of ulcerative colitis with positive proteinase-3 antineutrophil cytoplasmic antibody.
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Diagnostic accuracy of serum proteinase 3 antineutrophil cytoplasmic antibodies in children with ulcerative colitis.
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis.
PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.
PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC).
Pulmonary complications resembling Wegener's granulomatosis in ulcerative colitis with elevated proteinase-3 anti-neutrophil cytoplasmic antibody.
[Antineutrophil cytoplasmic antibodies and nonspecific ulcerative colitis]
Communicable Diseases
Proteinase 3 expression on neutrophil membranes from patients with infectious disease.
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Connective Tissue Diseases
Clinical significance of thyroid hormone and antibodies in patients with idiopathic interstitial pneumonia.
COVID-19
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection.
The Inflammatory Factors Associated with Disease Severity to Predict COVID-19 Progression.
Crohn Disease
Antibodies to cathepsin G in Crohn's disease.
PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.
Cystic Fibrosis
Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts.
Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease.
Proteinase 3 mRNA expression is induced in monocytes but not in neutrophils of patients with cystic fibrosis.
Proteinase 3, a potent secretagogue in airways, is present in cystic fibrosis sputum.
Deafness
Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.
Dental Caries
Role of saliva proteinase 3 in dental caries.
Diabetes Mellitus
[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults].
Diabetes Mellitus, Type 1
Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with ?-cell autoimmunity in patients with type 1 diabetes.
Proteinase-3 and Type 1 Diabetes: A New Target for Treatment?
[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults].
Diabetes Mellitus, Type 2
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study.
[Changes and clinical significance of serum proteinase 3 in latent autoimmune diabetes in adults].
Diabetic Ketoacidosis
Elevated Leukocyte Azurophilic Enzymes in Human Diabetic Ketoacidosis Plasma Degrade Cerebrovascular Endothelial Junctional Proteins.
Embolism, Cholesterol
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review.
Endocarditis
2020 international consensus on ANCA testing beyond systemic vasculitis.
A Japanese case of proteinase 3 antineutrophil cytoplasmic autoantibody-associated pauci-immune-type crescentic glomerulonephritis without valvular endocarditis.
Antineutrophil cytoplasmic antibodies (ANCA)-positive patient with infective endocarditis and chronic hepatitis B virus: a case report and review of the literature.
Endocarditis, Bacterial
Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis.
Bacterial endocarditis associated with proteinase 3 anti-neutrophil cytoplasm antibody.
Endocarditis, Subacute Bacterial
The presence of cytoplasmic antineutrophil cytoplasmic antibodies (C-ANCA) in the course of subacute bacterial endocarditis with glomerular involvement, coincidence or association?
Eosinophilia
Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase.
[The Churg-Strauss syndrome]
Epididymitis
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Exophthalmos
[A case of Wegener's granulomatosis with orbital inflammatory pseudotumor]
Facial Paralysis
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Fatty Liver
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Glioblastoma
Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail.
Glomerulonephritis
A Japanese case of proteinase 3 antineutrophil cytoplasmic autoantibody-associated pauci-immune-type crescentic glomerulonephritis without valvular endocarditis.
ANCA-associated pauci-immune glomerulonephritis in a patient with bacterial endocarditis: a challenging clinical dilemma.
ANCA-positive crescentic glomerulonephritis associated with minocycline therapy.
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders.
Antineutrophil cytoplasmic autoantibodies-antigen specificity and associated diseases.
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
cANCA-associated aortitis.
Complement Components C3 and C4 Indicate Vasculitis Manifestations to Distinct Renal Compartments in ANCA-Associated Glomerulonephritis.
Correlation of antineutrophil cytoplasmic antibodies with the extrarenal histopathology of Wegener's (pathergic) granulomatosis and related forms of vasculitis.
Diagnostic algorithm for antineutrophil cytoplasmic antibody-associated systemic vasculitis.
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.
Dual anti-neutrophil cytoplasmic antibody-related pauci-immune crescentic glomerulonephritis in a patient with Sjögren's syndrome.
IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis.
Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study.
In vitro neutrophil activation by antibodies to proteinase 3 and myeloperoxidase from patients with crescentic glomerulonephritis.
Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.
PR3 and Elastase Alter PAR1 Signaling and Trigger vWF Release via a Calcium-Independent Mechanism from Glomerular Endothelial Cells.
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Rapid screening assay for anti-GBM antibody and ANCAs; an important tool for the differential diagnosis of pulmonary renal syndromes.
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Renal-limited vasculitis with elevated levels of multiple antibodies.
Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice.
Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis.
Scleroderma with crescentic glomerulonephritis: a case report.
Staphylococcus aureus and Wegener's granulomatosis.
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Valvular injury in a patient with PR3-ANCA-associated glomerulonephritis.
Vasculitis following implantation of a ventriculoperitoneal shunt tube made of silicone.
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
[A case of refractory Wegener's granulomatosis successfully treated with high-dose methotrexate]
[Are antineutrophil cytoplasmic antibodies pathogenic?]
[Rapid-detection GBM-ANCA ELISA. An emergency tool for the early diagnosis of type I and II rapidly progressive glomerulonephritis]
Glomerulonephritis, IGA
Is presence of ANCA in crescentic IgA nephropathy a coincidence or novel clinical entity? A case series.
Granuloma
Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease.
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Should nasal biopsy inevitably be performed for classifying granulomatosis with polyangiitis in patients with rhinosinusitis? A retrospective chart review study.
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.
Granulomatosis with Polyangiitis
'Classic' anti-neutrophil cytoplasmic autoantibodies (cANCA), 'Wegener's autoantigen' and their immunopathogenic role in Wegener's granulomatosis.
18F-FDG PET/CT Findings Preceded Elevation of Serum Proteinase 3 Antineutrophil Cytoplasmic Antibodies in Wegener Granulomatosis.
4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis.
A case of (double) ANCA-negative granulomatosis with polyangiitis (Wegener's).
A Case of Suspected Hepatically Localized Granulomatosis with Polyangiitis.
A case of Wegener's granulomatosis associated with progressive dysphagia owing to esophageal involvement.
A Case Report on Suspected Levamisole-Induced Pseudovasculitis.
A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis.
A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegener's granulomatosis.
A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors.
A Monoclonal Antibody (MCPR3-7) Interfering with the Activity of Proteinase 3 by an Allosteric Mechanism.
A new approach to the molecular characterization of the c-ANCA antigen in Wegener's granulomatosis.
A novel high sensitivity ELISA for detection of antineutrophil cytoplasm antibodies against proteinase-3.
A review of immunofluorescent patterns associated with antineutrophil cytoplasmic antibodies (ANCA) and their differentiation from other antibodies.
A simple high yield procedure for purification of human proteinase 3, the main molecular target of cANCA.
A substrate-based approach to convert SerpinB1 into a specific inhibitor of proteinase 3, the Wegener's granulomatosis autoantigen.
Advances in pathogenesis and treatment of ANCA-associated vasculitis.
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.
Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis.
Alpha 1-antitrypsin phenotypes in patients with anti-neutrophil cytoplasmic antibody-positive vasculitis.
Alterations of serum levels of plasminogen, TNF-?, and IDO in granulomatosis with polyangiitis patients.
Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.
Analysis of a biomarker for Wegener's granulomatosis.
Analysis of T-cell receptor usage in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
ANCA-Associated Vasculitides and Hematologic Malignancies: Lessons from the Past and Future Perspectives.
Anti-cytoplasmic antibodies in Wegener's granulomatosis are directed against proteinase 3.
Anti-neutrophil cytoplasm antibodies (ANCA).
Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener's granulomatosis: a possible pathogenic role for the IgG4 subclass.
Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site.
Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa.
Anti-neutrophil cytoplasmic antibodies in patients with chromomycosis.
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Anti-proteinase 3 antibodies (c-ANCA) prime CD14-dependent leukocyte activation.
Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells.
Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1).
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Antineutrophil cytoplasmic antibodies (ANCA) and systemic vasculitis: update of assays, immunopathogenesis, controversies, and report of a novel de novo ANCA-associated vasculitis after kidney transplantation.
Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus.
Antineutrophil cytoplasmic antibodies in Wegener's granulomatosis and other diseases: clinical issues.
Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.
Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis.
Antineutrophil cytoplasmic antibodies to proteinase 3 in Wegener's granulomatosis: epitope analysis using synthetic peptides.
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
Antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis recognize conformational epitope(s) on proteinase 3.
Antineutrophil cytoplasmic autoantibodies-antigen specificity and associated diseases.
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
Autoantibodies and target antigens in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides.
Autoantibodies in vasculitis.
Autoantibodies to neutrophil cytoplasmic antigens (ANCA) do not bind to polymorphonuclear neutrophils in blood.
B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions.
Bilateral Facial Nerve Palsy due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody.
Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?
Blindness in a Sri Lankan woman with bilateral breast lumps: a case report.
c-ANCA induce neutrophil-mediated lung injury -a model of acute Wegener's Granulomatosis.
Capture-ELISA based on recombinant PR3 is sensitive for PR3-ANCA testing and allows detection of PR3 and PR3-ANCA/PR3 immunecomplexes.
Changes in proteinase 3 anti-neutrophil cytoplasm autoantibody levels in early systemic granulomatosis with polyangiitis (Wegener's) may reflect treatment rather than disease activity.
Characterization and localization of the genes for mouse proteinase-3 (Prtn3) and neutrophil elastase (Ela2).
Characterization of a recombinant proteinase 3, the autoantigen in Wegener's granulomatosis and its reactivity with anti-neutrophil cytoplasmic autoantibodies.
Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3.
Characterization of monoclonal antibodies to proteinase-3 and application in the study of epitopes for classical anti-neutrophil cytoplasm antibodies.
Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3.
Clinical and prognostic features of Korean patients with MPO-ANCA, PR3-ANCA and ANCA-negative vasculitis.
Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan otological society.
Clinical features and outcome in patients with glomerulonephritis and antineutrophil cytoplasmic autoantibodies.
Clinically-irrelevant positivity for serum proteinase 3-ANCA in HIV disease.
Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis.
Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils.
Comparative aspects of murine proteinase 3.
Comparative investigation of respiratory tract involvement in granulomatosis with polyangiitis between PR3-ANCA positive and MPO-ANCA positive cases: a retrospective cohort study.
Complexes between proteinase 3, alpha 1-antitrypsin and proteinase 3 anti-neutrophil cytoplasm autoantibodies: a comparison between alpha 1-antitrypsin PiZ allele carriers and non-carriers with Wegener's granulomatosis.
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
Constitutive membrane expression of proteinase 3 (PR3) and neutrophil activation by anti-PR3 antibodies.
Current State of Biologicals in the Management of Systemic Vasculitis.
Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.
Detachment and cytolysis of human endothelial cells by proteinase 3.
Determination of anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: Comparative analysis of different strategies.
Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease.
Different forms of alpha-1 antitrypsin and neutrophil activation mediated by human anti-PR3 IgG antibodies.
Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Distinct proteinase 3-induced cytokine patterns in Wegener´s granulomatosis, Churg-Strauss syndrome, and healthy controls.
Diversity of PR3-ANCA epitope specificity in Wegener's granulomatosis. Analysis using the biosensor technology.
Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA.
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Endothelial cells and renal epithelial cells do not express the Wegener's autoantigen, proteinase 3.
Epitope mapping on Wegener's granulomatosis autoantigen proteinase 3.
Epitope-specific anti-neutrophil cytoplasmic antibodies: do they matter? Can they be detected?
Epitopes on proteinase-3 recognized by antibodies from patients with Wegener's granulomatosis.
Evaluation of capture ELISA for detection of antineutrophil cytoplasmic antibodies directed against proteinase 3 in Wegener's granulomatosis: first results from a multicentre study.
Expression of recombinant proteinase 3, the autoantigen in Wegener's granulomatosis, in insect cells.
Expression profile of proinflammatory genes in neutrophil-enriched granulocytes stimulated with native anti-PR3 autoantibodies.
Frequency of proteinase 3 (PR3)-specific autoreactive T cells determined by cytokine flow cytometry in Wegener's granulomatosis.
Fulminant Wegener's granulomatosis presenting as epistaxis.
Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis.
Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3.
Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.
Genetic variants in ANCA-associated vasculitis: a meta-analysis.
Genetics and pathophysiology of granulomatosis with polyangiitis (GPA) and its main autoantigen proteinase 3.
Genetics of ANCA-associated vasculitides: HLA and beyond.
Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis.
Granulomatosis with polyangiitis (Wegener granulomatosis): A proteinase-3 driven disease?
High-sensitivity detection of autoantibodies against proteinase-3 by a novel third-generation enzyme-linked immunosorbent assay.
Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis.
Image analysis: a novel approach for the quantification of antineutrophil cytoplasmic antibody levels in patients with Wegener's granulomatosis.
Immunity in the connective tissue diseases. The humoral side of the coin.
Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration.
Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis.
Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis.
Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression.
Immunologic markers for differentiation of autoimmune responses.
In situ detection of PR3-ANCA+ B cells and alterations in the variable region of immunoglobulin genes support a role of inflamed tissue in the emergence of auto-reactivity in granulomatosis with polyangiitis.
In vitro interactions of c-ANCA (antibodies to proteinase 3) with human endothelial cells.
In vitro T lymphocyte responses to proteinase 3 (PR3) and linear peptides of PR3 in patients with Wegener's granulomatosis (WG).
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.
Increased expression of the secretory leukocyte proteinase inhibitor in Wegener's granulomatosis.
Induction of proteinase 3-anti-neutrophil cytoplasmic autoantibodies by proteinase 3-homologous bacterial protease in mice.
Inhibition of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis.
Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease.
Interaction of antibodies to proteinase 3 (classic anti-neutrophil cytoplasmic antibody) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation.
Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils.
Interaction of proteinase 3 with its associated partners: implications in the pathogenesis of Wegener's granulomatosis.
Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers.
Interference of PR3-ANCA with the enzymatic activity of PR3: differences in patients during active disease or remission of Wegener's granulomatosis.
Interference of Wegener's granulomatosis autoantibodies with neutrophil Proteinase 3 activity.
Isolation of a protein complex from purulent sputum consisting of proteinase-3 and alpha 1-antitrypsin reactive with anti neutrophil cytoplasmic antibodies.
Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis.
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.
Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3.
Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study.
Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis.
Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides.
Membrane proteinase 3 (mPR3) expression on neutrophils is not increased in localized Wegener's granulomatosis (WG) and Churg-Strauss syndrome (CSS).
Membrane proteinase 3 and Wegener's granulomatosis.
Membrane proteinase 3 expression and ANCA-induced neutrophil activation.
Membrane proteinase 3 expression in patients with Wegener's granulomatosis and in human hematopoietic stem cell-derived neutrophils.
Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation.
Membrane-bound proteinase 3 and its receptors: Relevance for the pathogenesis of Wegener's Granulomatosis.
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.
Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China.
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Neutrophil granule proteins as targets of leukemia-specific immune responses.
Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis.
Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).
Neutrophil-specific antigen HNA-2a, NB1 glycoprotein, and CD177.
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Nomenclature and classification of vasculitis: lessons learned from granulomatosis with polyangiitis (Wegener's granulomatosis).
Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene.
On the origin of surface proteinase 3 of nonmyeloid cells: evidence favoring an exogenous source.
Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention.
Pathogenesis of PR3-ANCA associated vasculitis.
Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study.
Performance evaluation of three assays for the detection of PR3-ANCA in granulomatosis with polyangiitis in daily practice.
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Positive c-ANCA in a Patient with Lymphoma and Without Vasculitis.
Prediction of relapses in Wegener's granulomatosis by measurement of antineutrophil cytoplasmic antibody levels: a prospective study.
Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules.
Proposal for a more practical classification of antineutrophil cytoplasmic antibody-associated vasculitis.
Protein microarrays with carbon nanotubes as multicolor Raman labels.
Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1.
Proteinase 3 gene polymorphisms and Wegener's granulomatosis.
Proteinase 3 interacts with a 111-kD membrane molecule of human umbilical vein endothelial cells.
Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.
Proteinase 3 is a phosphatidylserine binding protein which affects the production and function of microvesicles.
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
Proteinase 3, protease-activated receptor-2 and interleukin-32: linking innate and autoimmunity in Wegener's granulomatosis.
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.
Proteinase 3, the target antigen of anticytoplasmic antibodies circulating in Wegener's granulomatosis. Immunolocalization in normal and pathologic tissues.
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.
Proteinase 3: substrate specificity and possible pathogenetic effect of Wegener's granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme.
Proteinase 3: the odd one out that became an autoantigen.
Proteinase-3 antineutrophil cytoplasm antibody positivity in patients without primary systemic vasculitis.
Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis.
Proteinase-3 mRNA expressed by glomerular epithelial cells correlates with crescent formation in Wegener's granulomatosis.
Proteolysis of classic anti-neutrophil cytoplasmic autoantibodies (C-ANCA) by neutrophil proteinase 3.
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.
Protracted superficial Wegener's granulomatosis.
Pulmonary capillaritis in Wegener's granulomatosis detected via transbronchial lung biopsy.
Pulmonary complications resembling Wegener's granulomatosis in ulcerative colitis with elevated proteinase-3 anti-neutrophil cytoplasmic antibody.
Purification of Wegener's granulomatosis autoantigen, proteinase 3, from neutrophils by Triton X-114 extraction of azurophilic granules.
Recombinant proteinase 3 produced in different expression systems: recognition by anti-PR3 antibodies.
Relation between asymptomatic proteinase 3 antibodies and future granulomatosis with polyangiitis.
Relevance of classic anti-neutrophil cytoplasmic autoantibody (C-ANCA)-mediated inhibition of proteinase 3-alpha 1-antitrypsin complexation to disease activity in Wegener's granulomatosis.
Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors.
Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener's granulomatosis.
Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis.
Rituximab for refractory Wegener's granulomatosis.
Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's).
Role of ANCA in the pathogenesis of Wegener's granulomatosis: a short review.
Severe CNS manifestations as the clinical hallmark in generalized Wegener's granulomatosis consistently negative for antineutrophil cytoplasmic antibodies (ANCA). A report of 3 cases and a review of the literature.
Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions.
Structural analysis of human antibodies to proteinase 3 from patients with Wegener granulomatosis.
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Subthreshold concentrations of anti-proteinase 3 antibodies (c-ANCA) specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis.
Systemic necrotizing vasculitis.
T cell reactivity to proteinase 3 and myeloperoxidase in patients with Wegener's granulomatosis (WG).
The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity.
The binding of proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) varies in different ELISAs.
The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies.
The influence of different cultivating conditions on polymorphonuclear leukocyte apoptotic process in vitro, II: ultrastructural characteristics of PMN populations incubated with proteinase 3 anti-neutrophil autoantibodies.
The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558.
The role of proteinase 3 (PR3) and the protease-activated receptor-2 (PAR-2) pathway in dendritic cell (DC) maturation of human-DC-like monocytes and murine DC.
The role of the c-ANCA antigen in the pathogenesis of Wegener's granulomatosis. A hypothesis based on both humoral and cellular mechanisms.
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Treatment of granulomatosis with polyangiitis (Wegener's).
Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis.
Vasculitis.
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.
Wegener's granulomatosis and antineutrophil cytoplasmic autoantibodies.
Wegener's granulomatosis associated with renal cell carcinoma.
Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase.
Wegener's granulomatosis presenting as pyoderma gangrenosum.
Wegener's granulomatosis.
Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response.
Wegener's granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine cell activation.
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
What you should know about PR3-ANCA. Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA.
When a wound is the harbinger of a serious underlying systemic illness.
[A case of squamous cell carcinoma of the lung with a high titer of proteinase 3 antineutrophil cytoplasmic antibody]
[A case of Wegener's granulomatosis with episcleritis, mediastinal lesions, and pleural effusion and without serum anti-neutrophil cytoplasmic antibodies]
[A case of Wegener's granulomatosis with orbital inflammatory pseudotumor]
[ANCA-associated forms of vasculitis]
[Anti-neutrophil cytoplasmic autoantibody (ANCA) in systemic vasculitic syndrome]
[Antineutrophilic cytoplasmic antibodies (ANCA) in inflammatory rheumatic diseases: immunodiagnostic and immunopathogenetic aspects]
[Are antineutrophil cytoplasmic antibodies pathogenic?]
[Atypical location of Wegener's granulomatosis with breast involvement: case report].
[B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis : Origin of anti-neutrophil cytoplasmic antibody formation?]
[Classification of systemic vasculatides]
[Clinical and pathogenetic aspects of kidney damage associated with neutrophilic cytoplasm antibodies]
[Distribution pattern of proteinase 3 in Wegener's granulomatosis and other vasculitic diseases]
[Microscopic polyangiitis]
[New aspects of antineutrophil cytoplasmic antibody (ANCA) diagnosis in vasculitis]
[New aspects of the pathogenesis of gout : Danger signals, autoinflammation and beyond.]
[Subglottal stenosis as the first symptom of Wegener's granulomatosis]
[The clinical analysis of 46 cases with antineutrophil cytoplasmic antibody-associated vasculitis].
[The complement system in the pathogenesis of antineutrophil cytoplasm antibodies-associated vasculitis].
[Wegener's granulomatosis and microscopic polyangiitis]
Graves Disease
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.
Hearing Loss
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Defective Tmprss3-Associated Hair Cell Degeneration in Inner Ear Organoids.
Tmprss3, a transmembrane serine protease deficient in human DFNB8/10 deafness, is critical for cochlear hair cell survival at the onset of hearing.
[Wegener's granulomatosis (WG) presented with hearing loss and without positive serologic ANCA]
Hearing Loss, Sensorineural
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Heart Block
Limited Wegener's granulomatosis presenting with complete heart block.
Heart Failure
Proteinase 3 and prognosis of patients with acute myocardial infarction.
Hematologic Neoplasms
Clinical peptide vaccination trials for leukemia patients.
Hematuria
Carbimazole-Induced, ANCA-Associated, Crescentic Glomerulonephritis: Case Report and Literature Review.
Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis.
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Valvular injury in a patient with PR3-ANCA-associated glomerulonephritis.
Hemoglobinuria
Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria.
Proteinase 3 expression on the neutrophils of patients with paroxysmal nocturnal hemoglobinuria.
Hemoglobinuria, Paroxysmal
Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria.
Proteinase 3 expression on the neutrophils of patients with paroxysmal nocturnal hemoglobinuria.
Hepatitis
Severe ductopenia and cholestasis from levofloxacin drug-induced liver injury: a case report and review.
Hepatitis B
Famciclovir-induced leukocytoclastic vasculitis.
Hepatitis B, Chronic
Antineutrophil cytoplasmic antibodies (ANCA)-positive patient with infective endocarditis and chronic hepatitis B virus: a case report and review of the literature.
Hepatitis C
A rare and severe cutaneous adverse effect of telaprevir: drug rash with eosinophilia and systemic symptoms.
First case of drug rash eosinophilia and systemic symptoms due to boceprevir.
Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection.
Hepatitis, Autoimmune
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Hypergammaglobulinemia
Clinically-irrelevant positivity for serum proteinase 3-ANCA in HIV disease.
Hyperglycemia
Comprehensive transcriptome analysis of colorectal cancer risk of hyperglycemia in humans.
Hyperthyroidism
Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA.
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Idiopathic Interstitial Pneumonias
2020 international consensus on ANCA testing beyond systemic vasculitis.
Infections
Antineutrophil cytoplasmic antibodies (ANCA) and small vessel vasculitis.
Corynebacterium jeikeium pacemaker infection associated with antineutrophil cytoplasmic antibodies: a single positive blood culture could be sufficient for diagnosis.
Immunological interactions of Chilo suppressalis Walker (Lepidoptera: Crambidae) with the native entomopathogenic fungi.
Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice.
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
LTF, PRTN3, and MNDA in Synovial Fluid as Promising Biomarkers for Periprosthetic Joint Infection: Identification by Quadrupole Orbital-Trap Mass Spectrometry.
NETosis delays diabetic wound healing in mice and humans.
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1? processing during Streptococcus pneumoniae infection.
Prolonged infections associated with antineutrophil cytoplasmic antibodies specific to proteinase 3 and myeloperoxidase: diagnostic and therapeutic challenge.
Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches.
Proteinase 3 and dihydrolipoamide dehydrogenase (E3) are major autoantigens in hepatitis C virus (HCV) infection.
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Selective inhibitors of human neutrophil proteinase 3.
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection.
The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Infertility
Malignant Pyoderma Associated with Granulomatosis with Polyangiitis (Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I.
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study.
Antineutrophil Cytoplasmic Antibodies in Inflammatory Bowel Disease and Collagenous Colitis: No Association with Lactoferrin, ?-Glucuronidase, Myeloperoxidase, or Proteinase 3.
Antineutrophil cytoplasmic autoantibodies in inflammatory bowel diseases.
Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease.
PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC).
The diagnostic role and clinical association of serum proteinase 3 anti-neutrophil cytoplasmic antibodies in Chinese patients with inflammatory bowel disease.
Influenza, Human
Critical Role of SerpinB1 in Regulating Inflammatory Responses in Pulmonary Influenza Infection.
Viral RNA in the influenza vaccine may have contributed to the development of ANCA-associated vasculitis in a patient following immunisation.
Insulin Resistance
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Intestinal Diseases
Diagnostic and clinical role of serum proteinase 3 antineutrophil cytoplasmic antibodies in inflammatory bowel disease.
Kidney Failure, Chronic
Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
De novo glomerulonephritis in patients during remission from Wegener's granulomatosis.
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Impact of Proteinase 3 versus Myeloperoxidase Positivity on Risk of End-Stage Renal Disease in ANCA-Associated Glomerulonephritis Stratified by Histological Classification: A Population-Based Cohort Study.
Latent Tuberculosis
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
Leukemia
Arsenic trioxide augments all-trans retinoic acid-induced differentiation of HL-60 cells.
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3.
Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.
Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells.
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units.
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
Functional interactions between bile acids, all-trans retinoic acid, and 1,25-dihydroxy-vitamin D3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells.
Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells.
Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid.
Neutrophil granule proteins as targets of leukemia-specific immune responses.
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Proteinase 3 (PR3) gene is highly expressed in CBF leukemias and codes for a protein with abnormal nuclear localization that confers drug sensitivity.
Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.
Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid.
Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells.
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
Wegener's autoantigen and leukemia.
WITHDRAWN: Proteinase 3 (PR3) gene is highly expressed in CBF leukemias and codes for a protein with abnormal nuclear localization that confers drug sensitivity.
Leukemia, Lymphoid
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells.
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units.
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects.
Interferon-alpha, but not the ABL-kinase inhibitor imatinib (STI571), induces expression of myeloblastin and a specific T-cell response in chronic myeloid leukemia.
Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses.
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells.
Leukemia, Myeloid
A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia.
An anti-PR1/HLA-A2 T cell receptor-like antibody mediates complement dependent cytotoxicity against acute myeloid leukemia progenitor cells.
Characterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice.
Donor-recipient polymorphism of the proteinase 3 gene: a potential target for T-cell alloresponses to myeloid leukemia.
Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase.
In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins.
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy.
Myeloblastin is an Myb target gene: mechanisms of regulation in myeloid leukemia cells growth-arrested by retinoic acid.
PR1 peptide vaccine induces specific immunity with clinical responses in myeloid malignancies.
Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.
Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid.
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells.
The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1.
Leukemia, Myeloid, Acute
A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells.
Activity of 8F4, a T-cell receptor-like anti-PR1/HLA-A2 antibody, against primary human AML in vivo.
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation.
Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909.
Wegener autoantigen and myeloblastin are encoded by a single mRNA.
Liver Diseases
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease.
Antineutrophil cytoplasmic antibody profiles differ according to type of primary sclerosing cholangitis and autoimmune hepatitis.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Simultaneous automated screening and confirmatory testing for vasculitis-specific ANCA.
Lung Diseases
A case of proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) positive/IgG4-related lung disease.
Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases.
Sjögren's syndrome, cavitating lung disease and high sustained levels of antibodies to serine proteinase 3.
Lung Diseases, Interstitial
Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies.
Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3.
Lung Neoplasms
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Lupus Erythematosus, Systemic
Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.
Case of systemic lupus erythematosus with strong proteinase 3 antineutrophil cytoplasmic antibody positivity.
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Immunologic markers for differentiation of autoimmune responses.
[New aspects of the pathogenesis of gout : Danger signals, autoinflammation and beyond.]
Lupus Nephritis
ANCA positivity at the time of renal biopsy is associated with chronicity index of lupus nephritis.
Differences in clinico-pathological characteristics and outcomes between proteinase 3-ANCA positivity and myeloperoxidase-ANCA positivity in lupus nephritis.
Scleroderma with crescentic glomerulonephritis: a case report.
Lymphoma
Can antineutrophil cytoplasmic antibody positivity at diagnosis predict the poor outcomes of Sjögren's syndrome?
Lymphoma, B-Cell
Cross Talk Between TGF-? and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy.
Effect of MiR-210 on the Chemosensitivity of Breast Cancer by Regulating JAK-STAT Signaling Pathway.
Effect of miR-26a on diabetic rats with myocardial injury by targeting PTEN.
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
Inhibition of Wnt3a/FOXM1/?-Catenin Axis and Activation of GSK3? and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers.
Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway.
Remifentanil protects neurological function of rats with cerebral ischemia-reperfusion injury via NR2B/CaMKII? signaling pathway.
Lymphoma, Non-Hodgkin
Positive c-ANCA in a Patient with Lymphoma and Without Vasculitis.
Mastitis
Global transcriptomic profiles of circulating leucocytes in early lactation cows with clinical or subclinical mastitis.
Maxillary Sinusitis
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Melanoma
Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens.
Natural T cell immunity against cancer.
Meningitis
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Microscopic Polyangiitis
A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis.
Advances in pathogenesis and treatment of ANCA-associated vasculitis.
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis.
Antiproteinase 3- and antimyeloperoxidase-associated vasculitis.
Autoantibodies in vasculitis.
Binding of proteinase 3 and myeloperoxidase to endothelial cells: ANCA-mediated endothelial damage through ADCC?
Clinical and prognostic features of Korean patients with MPO-ANCA, PR3-ANCA and ANCA-negative vasculitis.
Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan otological society.
Determination of anti-neutrophil cytoplasmic antibodies in small vessel vasculitis: Comparative analysis of different strategies.
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Effects of carboxy-terminal modifications of proteinase 3 (PR3) on the recognition by PR3-ANCA.
Epitope-specific anti-neutrophil cytoplasmic antibodies: do they matter? Can they be detected?
Genetic variants in ANCA-associated vasculitis: a meta-analysis.
Genetics of ANCA-associated vasculitides: HLA and beyond.
Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis.
Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis.
In vitro up-regulation of E-selectin and induction of interleukin-6 in endothelial cells by autoantibodies in Wegener's granulomatosis and microscopic polyangiitis.
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.
Long-term outcome of severe alveolar haemorrhage in ANCA-associated vasculitis: a retrospective cohort study.
Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides.
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Myeloperoxidase-ANCA-Positive and ANCA-Negative Patients With Granulomatosis With Polyangiitis: Distinct Patient Subsets.
Myeloperoxidase-ANCA-positive granulomatosis with polyangiitis is a distinct subset of ANCA-associated vasculitis: A retrospective analysis of 455 patients from a single center in China.
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention.
Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Pathophysiology of ANCA-associated small vessel vasculitis.
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction.
Proposal for a more practical classification of antineutrophil cytoplasmic antibody-associated vasculitis.
Renal histology in Chinese patients with anti-myeloperoxidase autoantibody-positive Wegener's granulomatosis.
Systemic necrotizing vasculitis.
Systemic vasculitis and the lung.
The biology, pathogenetic role, clinical implications, and open issues of serum anti-neutrophil cytoplasmic antibodies.
TNF-alpha bioactivity-inhibiting therapy in ANCA-associated vasculitis: clinical and experimental considerations.
Unusually indolent MPO-ANCA: associated vasculitis-report of two cases.
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
[ANCA-associated forms of vasculitis]
[Antineutrophilic cytoplasmic antibodies (ANCA) in inflammatory rheumatic diseases: immunodiagnostic and immunopathogenetic aspects]
[Classification of systemic vasculatides]
[Microscopic polyangiitis]
[New aspects of antineutrophil cytoplasmic antibody (ANCA) diagnosis in vasculitis]
[The clinical analysis of 46 cases with antineutrophil cytoplasmic antibody-associated vasculitis].
[The complement system in the pathogenesis of antineutrophil cytoplasm antibodies-associated vasculitis].
[Wegener's granulomatosis and microscopic polyangiitis]
Mixed Connective Tissue Disease
Mixed connective tissue disease associated with antineutrophil cytoplasmic antibodies against proteinase-3 and systemic atherosclerosis: a case report.
[A case of mixed connective tissue disease positive for proteinase 3 antineutrophil cytoplasmic antibody in a patient with slowly progressive type 1 diabetes mellitus and chronic thyroiditis].
Mononeuropathies
Audit of the clinical usefulness of a rapid qualitative ELISA screen for antimyeloperoxidase and antiproteinase 3 antibodies in the assessment of patients with suspected vasculitis.
Multiple Myeloma
A Case Report of Multiple Myeloma Associated With Myeloperoxidase and Proteinase-3 Antibodies Posing a Diagnostic Dilemma.
Muscular Dystrophies, Limb-Girdle
Prenatal diagnosis of limb-girdle muscular dystrophy type 2A.
myeloblastin deficiency
Characterization of neutrophil function in Papillon-Lefèvre syndrome.
Myocardial Infarction
Proteinase 3 and prognosis of patients with acute myocardial infarction.
Neoplasm Metastasis
A large-scale transcriptome analysis identified ELANE and PRTN3 as novel methylation prognostic signatures for clear cell renal cell carcinoma.
Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Neoplasm, Residual
Inflammation and cancer: inhibiting the progression of residual hepatic VX2 carcinoma by anti-inflammatory drug after incomplete radiofrequency ablation.
Neoplasms
A High-Cholesterol Diet Increases Toll-like Receptors and Other Harmful Factors in the Rabbit Myocardium: The Beneficial Effect of Statins.
Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo.
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent.
Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy.
Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3.
Cross Talk Between TGF-? and JAK Expressions and Nepherotoxicity Induced by Tetrachloromethane: Role of Phytotherapy.
Crosslinking of ANCA-antigens stimulates superoxide release by human neutrophils.
De novo synthesis of proteinase 3 by cytokine primed circulating human polymorphonuclear neutrophils and mononuclear cells.
Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis.
Expression of myeloperoxidase (MPO) by neutrophils is necessary for their activation by anti-neutrophil cytoplasm autoantibodies (ANCA) against MPO.
Febrile temperatures control antineutrophil cytoplasmic autoantibody-induced neutrophil activation via inhibition of phosphatidylinositol 3-kinase/Akt.
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Hepatoprotective effect of rhein against methotrexate-induced liver toxicity.
Identification of novel functional sequence variants in the gene for peptidase inhibitor 3.
In vivo tumor growth inhibition by Solanum tuberosum aspartic protease 3 (StAP3) treatment.
Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Low P4HA2 and high PRTN3 expression predicts poor survival in patients with pancreatic cancer.
MicroRNA216b mediated downregulation of HSP27/STAT3/AKT signaling is critically involved in lambertianic acid induced apoptosis in human cervical cancers.
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation.
PRSS3 is a prognostic marker in invasive ductal carcinoma of the breast.
SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
Serine Proteases Enhance Immunogenic Antigen Presentation on Lung Cancer Cells.
Sex differences in inflammatory and apoptotic signaling molecules in normal and diseased human gingiva.
Simvastatin Alleviates Intestinal Ischemia/Reperfusion Injury by Modulating Omi/HtrA2 Signaling Pathways.
The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer.
Translational mini-review series on vaccines: Peptide vaccines for myeloid leukaemias.
Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3.
Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis.
Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients.
Wegener's granulomatosis associated with renal cell carcinoma.
Nephritis
2020 international consensus on ANCA testing beyond systemic vasculitis.
A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis.
Antimyeloperoxidase and proteinase 3 antibodies for nephritis flare prediction in ANCA-associated-vasculitis.
Antineutrophil cytoplasmic autoantibody specific for proteinase 3 in a patient with shunt nephritis induced by Gemella morbillorum.
Shunt nephritis with positive titers for ANCA specific for proteinase 3.
Nephritis, Interstitial
Anti-neutrophil cytoplasmic antibodies in cholesterol embolism: A case report and literature review.
Cimetidine-induced tubulointerstitial nephritis with both MPO-ANCA and PR3-ANCA.
Neutropenia
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Non-alcoholic Fatty Liver Disease
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes.
Mice Deficient in the IL-1? Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD.
Osteoarthritis, Knee
[Effects of sand treatment in uyghur medicine on caspse-3, Bcl-2, Bax, and the apoptotic expression in the cartilage of rabbit knee osteoarthritis model].
Otitis
Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis.
Otitis Media
Bilateral Facial Nerve Palsy due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody.
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Intractable Otitis Media Presenting as Falsely Positive for Proteinase 3-ANCA: A Case Report.
[A case of Wegener's granulomatosis with orbital inflammatory pseudotumor]
Otitis Media with Effusion
Clinical features and treatment outcomes of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV): A retrospective analysis of 235 patients from a nationwide survey in Japan.
Pancreatic Neoplasms
Low P4HA2 and high PRTN3 expression predicts poor survival in patients with pancreatic cancer.
Pancreatitis
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Papilloma, Inverted
[The expression and significance of smac, XIAP, caspase-3 in nonasal inverted papilloma].
Peri-Implantitis
Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?
Periodontal Diseases
Are proteinase 3 and cathepsin C enzymes related to pathogenesis of periodontitis?
Lack of cathelicidin processing in Papillon-Lefèvre syndrome patients reveals essential role of LL-37 in periodontal homeostasis.
Periodontitis
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.
Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2.
Peripheral Nervous System Diseases
The complexity of classifying ANCA-associated small-vessel vasculitis in actual clinical practice: data from a multicenter retrospective survey.
Wegener's granulomatosis of the penis: genital presentation of systemic disease.
Peritonitis
Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pneumonia
Diagnostic value of antineutrophil cytoplasmic antibodies in children with bronchiolitis obliterans.
Regulation of hepatocyte growth factor in mice with pneumonia by peptidases and trans-alveolar flux.
Polyarteritis Nodosa
Anti-neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa.
Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa.
Prostatic Neoplasms
Interaction between Tumor Cell Surface Receptor RAGE and Proteinase 3 Mediates Prostate Cancer Metastasis to Bone.
Proteinuria
Carbimazole-Induced, ANCA-Associated, Crescentic Glomerulonephritis: Case Report and Literature Review.
Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats.
Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis.
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.
[Primary cutaneous manifestation of Wegener's granulomatosis]
[Severe chronic headache with depression induced by pachymeningitis in Wegener's granulomatosis]
Pseudomonas Infections
The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection.
Pulmonary Disease, Chronic Obstructive
?-1-antitrypsin variants and the proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease.
A specific proteinase 3 activity footprint in ?1-antitrypsin deficiency.
Characterizing the Dynamics and Ligand-Specific Interactions in the Human Leukocyte Elastase through Molecular Dynamics Simulations.
Dissociation between airway and systemic autoantibody responses in chronic obstructive pulmonary disease.
Elastolysis by proteinase 3 and its inhibition by alpha(1)-proteinase inhibitor: a mechanism for the incomplete inhibition of ongoing elastolysis.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Progranulin is a substrate for neutrophil-elastase and proteinase-3 in the airway and its concentration correlates with mediators of airway inflammation in COPD.
Proteases and antiproteases.
Proteinase 3 Activity in sputum from subjects with Alpha-1-Antitrypsin deficiency and COPD.
Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.
Specific elastin degradation products are associated with poor outcome in the ECLIPSE COPD cohort.
The Serpin Superfamily and Their Role in the Regulation and Dysfunction of Serine Protease Activity in COPD and Other Chronic Lung Diseases.
Pulmonary Edema
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Pulmonary Emphysema
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis.
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA).
Purpura
Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA.
[Difficulties in the differential diagnosis of kidney injury in a patient with infective endocarditis associated with antineutrophil cytoplasmic antibodies].
Pyoderma
[Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].
Renal Insufficiency
Aneurysmal subarachnoid hemorrhage in a patient with Wegener's granulomatosis.
Mizoribine as a safe and effective combined maintenance therapy with prednisolone for anti-neutrophil cytoplasmic antibody-associated vasculitis in a hemodialysis patient.
[Severe chronic headache with depression induced by pachymeningitis in Wegener's granulomatosis]
Respiratory Distress Syndrome
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Retinoblastoma
Perspectives on signaling for biological- and processed food-related advanced glycation end-products and its role in cancer progression.
Scleritis
Antineutrophil cytoplasmic antibody-positive scleritis: Clinical profile of patients from a tuberculosis-endemic region.
Membranous Nephropathy with Proteinase 3-ANCA-associated Vasculitis Successfully Treated with Rituximab.
Peripheral Ulcerative Keratitis Associated with Granulomatosis with Polyangiitis Emerging Despite Cyclophosphamide, Successfully Treated with Rituximab.
Scleroderma, Diffuse
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Scleroderma, Systemic
Autoantibodies to proteinase 3 and myeloperoxidase in systemic sclerosis.
Proteinase 3 (PR3)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitic neuropathy in diffuse cutaneous systemic sclerosis: a rare duo.
Sepsis
Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis.
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Proteinase 3 contributes to endothelial dysfunction in an experimental model of sepsis.
Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients.
Time Series Gene Expression Profiles Analysis Identified Several Potential Biomarkers for Sepsis.
Severe Acute Respiratory Syndrome
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Shock, Septic
Endothelial dysfunction is an early indicator of sepsis and neutrophil degranulation of septic shock in surgical patients.
Sinusitis
Eosinophilia in Wegener's granulomatosis.
Intravascular large B-cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis.
Reversible posterior leukoencephalopathy in a patient with Wegener granulomatosis.
Sjogren's Syndrome
Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer.
Skin Ulcer
A Case Report on Suspected Levamisole-Induced Pseudovasculitis.
Spondylitis, Ankylosing
Anti-lactoferrin antibodies and other types of anti-neutrophil cytoplasmic antibodies (ANCA) in reactive arthritis and ankylosing spondylitis.
Stomach Neoplasms
Prognostic value of auto-antibodies in the serum of Omani patients with gastric cancer.
Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer.
Synovitis
Antineutrophil cytoplasmic antibodies in synovial fluid and in serum of patients with rheumatoid arthritis and other types of synovitis.
Systemic Vasculitis
alpha 1-Antitrypsin (AAT) deficiency and ANCA-positive systemic vasculitis: genetic and clinical implications.
Anti-MPO-ANCA-positive microscopic polyangiitis following subacute bacterial endocarditis.
Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens.
Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site.
Anti-neutrophil cytoplasmic antibodies in generalized autoimmune diseases.
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders.
Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA).
Antigen specificities and clinical distribution of ANCA in kidney diseases.
Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.
Autoantibodies developing to myeloperoxidase and proteinase 3 in systemic vasculitis stimulate neutrophil cytotoxicity toward cultured endothelial cells.
Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall.
Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: Anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils.
Dendritic cell uptake of human apoptotic and necrotic neutrophils inhibits CD40, CD80, and CD86 expression and reduces allogeneic T cell responses: relevance to systemic vasculitis.
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.
Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression.
Eosinophil peroxidase differs from neutrophil myeloperoxidase in its ability to bind antineutrophil cytoplasmic antibodies reactive with myeloperoxidase.
Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission.
Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.
Neutrophil FcgammaRIIIb allelic polymorphism in anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
No association between neutrophil FcgammaRIIa allelic polymorphism and anti-neutrophil cytoplasmic antibody (ANCA)-positive systemic vasculitis.
Pathways to ANCA production: from differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegener's granuloma.
Prevalence and clinical significance of anti-lactoferrin autoantibodies in inflammatory bowel diseases and primary sclerosing cholangitis.
Prevalence of antineutrophil cytoplasmic antibodies in patients with various pulmonary diseases or multiorgan dysfunction.
Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.
Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro.
Proteinase-3 antineutrophil cytoplasm antibody positivity in patients without primary systemic vasculitis.
Pulmonary-renal vasculitic disorders: differential diagnosis and management.
Recombinant protein to analyze autoantibodies to proteinase 3 in systemic vasculitis.
Renal Survival in Proteinase 3 and Myeloperoxidase ANCA-Associated Systemic Vasculitis.
Respiratory failure in ANCA-associated vasculitis.
Review article: The role of CD4(+) T cells in ANCA-associated systemic vasculitis.
S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.
Significance of autoantibodies to purified proteinase 3 in systemic vasculitis.
Systemic vasculitis and the lung.
T cell responses to myeloperoxidase (MPO) and proteinase 3 (PR3) in patients with systemic vasculitis.
T lymphocyte responses to anti-neutrophil cytoplasmic autoantibody (ANCA) antigens are present in patients with ANCA-associated systemic vasculitis and persist during disease remission.
Use of antineutrophil cytoplasmic autoantibodies in diagnosing vasculitis in a Chinese patient population.
Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.
What is new with anti-neutrophil cytoplasmic antibodies: diagnostic, pathogenetic and therapeutic implications.
[Anti-cytoplasmic antibodies of polynucle or "ANCA". A new class of autoantibodies]
[Antibodies to proteinase-3 and myeloperoxidase in systemic vasculitis]
[B lymphocyte differentiation in granulomatous tissues of the lung and the nasal mucosa in Wegener's granulomatosis : Origin of anti-neutrophil cytoplasmic antibody formation?]
[Wegener's granulomatosis and ANCA-associated vasculitis: pathogenic role of autoantigens, autoantibodies, and cytokines]
Tachycardia
[The Churg-Strauss syndrome]
Thyroid Diseases
Association between thyroid disease and its treatment with ANCA small-vessel vasculitis: a case-control study.
Tuberculosis
Blindness in a Sri Lankan woman with bilateral breast lumps: a case report.
Low seroprevalence and poor specificity of antineutrophil cytoplasmic antibodies in tuberculosis.
Urinary Bladder Neoplasms
Analytical Performance of ELISA Assays in Urine: One More Bottleneck towards Biomarker Validation and Clinical Implementation.
Vascular Diseases
Antibodies with dual reactivity to plasminogen and complementary PR3 in PR3-ANCA vasculitis.
Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3.
Vascular System Injuries
Anti-neutrophil cytoplasm antibodies can recognize vascular endothelial cell-bound anti-neutrophil cytoplasm antibody-associated autoantigens.
Wegener's granulomatosis--autoimmunity to neutrophil proteinase 3.
Vasculitis
-463 G/A myeloperoxidase promoter polymorphism is associated with clinical manifestations and the course of disease in MPO-ANCA-associated vasculitis.
4C3 Human Monoclonal Antibody: A Proof of Concept for Non-pathogenic Proteinase 3 Anti-neutrophil Cytoplasmic Antibodies in Granulomatosis With Polyangiitis.
A case series and literature review on patients with rhinological complications secondary to the use of cocaine and levamisole.
A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis.
A myelopoiesis gene signature during remission in anti-neutrophil cytoplasm antibody-associated vasculitis does not predict relapses but seems to reflect ongoing prednisolone therapy.
A novel capture-ELISA for detection of anti-neutrophil cytoplasmic antibodies (ANCA) based on c-myc peptide recognition in carboxy-terminally tagged recombinant neutrophil serine proteases.
A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis.
A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis.
Advances in the genomics of ANCA-associated vasculitis-a view from East Asia.
Aggregatibacter aphrophilus infective endocarditis confirmed by broad-range PCR diagnosis: A case report.
Alterations of serum levels of plasminogen, TNF-?, and IDO in granulomatosis with polyangiitis patients.
An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report.
Analysis of anti-neutrophil cytoplasmic antibodies (ANCA): frequency and specificity in a sample of 191 homozygous (PiZZ) alpha1-antitrypsin-deficient subjects.
Analysis of T-cell receptor usage in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.
ANCA antigens, proteinase 3 and myeloperoxidase, are not expressed in endothelial cells.
ANCA autoantigen gene expression highlights neutrophil heterogeneity where expression in normal-density neutrophils correlates with ANCA-induced activation.
ANCA Glomerulonephritis and Vasculitis.
ANCA positive crescentic glomerulonephritis outcome in a Central East European cohort: a retrospective study.
ANCA-associated vasculitis.
ANCA-associated vasculitis: diagnostic and therapeutic strategy.
ANCA-small vessel vasculitides: what have we (not yet) learned from animal models?
Animal models of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Anti-glomerular basement membrane (anti-GBM) disease accompanied by vasculitis that was not positive for antineutrophil cytoplasmic antibodies to myeloperoxidase and proteinase 3: a report of two cases and the incidence of anti-GBM disease at one institution.
Anti-myeloperoxidase antibodies attenuate the monocyte response to LPS and shape macrophage development.
Anti-myeloperoxidase antibodies enhance phagocytosis, IL-8 production, and glucose uptake of polymorphonuclear neutrophils rather than anti-proteinase 3 antibodies leading to activation-induced cell death of the neutrophils.
Anti-myeloperoxidase antibodies in patients with microscopic polyangiitis.
Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis.
Anti-neutrophil cytoplasmic antibody-associated vasculitis, large vessel vasculitis and kawasaki disease in Japan.
Anti-neutrophil cytoplasmic autoantibodies and leukocyte-endothelial interactions: a sticky connection?
Anti-neutrophil cytoplasmic autoantibody pathogenicity revisited: pathogenic versus non-pathogenic anti-neutrophil cytoplasmic autoantibody.
Anti-oxidized low-density lipoprotein antibodies in myeloperoxidase-positive vasculitis patients preferentially recognize hypochlorite-modified low density lipoproteins.
Antibodies to proteinase 3 increase adhesion of neutrophils to human endothelial cells.
Antibodies to proteinase 3 mediate expression of vascular cell adhesion molecule-1 (VCAM-1).
Antigen-specific ANCA ELISAs have different sensitivities for active and treated vasculitis and for nonvasculitic disease.
Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel disease.
Antineutrophil cytoplasmic antibodies (ANCA).
Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus.
Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.
Antineutrophil cytoplasmic antibodies reacting with the pro form of proteinase 3 and disease activity in patients with Wegener's granulomatosis and microscopic polyangiitis.
Antineutrophil Cytoplasmic Antibodies, Autoimmune Neutropenia, and Vasculitis.
Antineutrophil cytoplasmic antibody (ANCA) vasculitis: pathophysiology, diagnosis, and the evolving treatment landscape.
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease.
Association of Cigarette Smoking With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Autoantibodies in vasculitis.
Bactericidal/permeability-increasing protein (BPI) is an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
Bilateral Facial Nerve Palsy due to Otitis Media Associated With Myeloperoxidase-Antineutrophil Cytoplasmic Antibody.
C3 and C4 allotypes in anti-neutrophil cytoplasmic autoantibody (ANCA)-positive vasculitis.
Classification of antineutrophil cytoplasmic autoantibody vasculitides: the role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis.
Clinical and immunological features of drug-induced and infection-induced proteinase 3-antineutrophil cytoplasmic antibodies and myeloperoxidase-antineutrophil cytoplasmic antibodies and vasculitis.
Clinical characteristics of patients with vasculitis positive for anti-neutrophil cytoplasmic antibody targeting both proteinase 3 and myeloperoxidase: a retrospective study.
Clinical manifestations and treatment of Wegener's granulomatosis.
Cloning and functional expression of the murine homologue of proteinase 3: implications for the design of murine models of vasculitis.
Cocaine-Induced Vasculitis.
Comparative aspects of murine proteinase 3.
Comparative evaluation of unfixed and fixed human neutrophils for determination of antineutrophil cytoplasmic antibodies by indirect immunofluorescence.
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
Cytotoxic effects of antibodies to proteinase 3 (C-ANCA) on human endothelial cells.
Difference in relapse-rate and clinical phenotype by autoantibody-subtype in Japanese patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
Differences between myeloperoxidase-antineutrophil cytoplasmic autoantibody (ANCA) and proteinase 3-ANCA associated vasculitis: A retrospective study from a single center in China.
Discrepancies between two immunoassays for the determination of MPO and PR3 autoantibodies.
Discrimination and variable impact of ANCA binding to different surface epitopes on proteinase 3, the Wegener's autoantigen.
Distinct differences in autoantigen specificity of anti-neutrophil cytoplasm antibodies in systemic vasculitides and other inflammatory diseases.
Dysregulation of autoantigen genes in ANCA-associated vasculitis involves alternative transcripts and new protein synthesis.
Effect of tumor necrosis factor-induced integrin activation on Fc gamma receptor II-mediated signal transduction: relevance for activation of neutrophils by anti-proteinase 3 or anti-myeloperoxidase antibodies.
Epitope mapping of anti-PR3 antibodies using chimeric human/mouse PR3 recombinant proteins.
Epitope shift of proteinase-3 anti-neutrophil cytoplasmic antibodies in patients with small vessel vasculitis.
Epitope-specific anti-neutrophil cytoplasmic antibodies: do they matter? Can they be detected?
Escherichia coli and Proteus mirabilis inhibit the perinuclear but not the circulating antineutrophil cytoplasmic antibody reaction.
Evaluation of PR3-ANCA Status After Rituximab for ANCA-Associated Vasculitis.
Exploring Frequencies of Circulating Specific Th17 Cells against Myeloperoxidase and Proteinase 3 in ANCA Associated Vasculitis.
Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial.
Frequency of anti-bactericidal/permeability-increasing protein (BPI) and anti-azurocidin in patients with renal disease.
Genetic aspects of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides.
Genetic variants in ANCA-associated vasculitis: a meta-analysis.
Granulomatosis with polyangiitis and associated pulmonary emphysema: Breathtaking vasculitis.
High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy.
Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
HLA genes in ANCA-associated vasculitides.
Human neutrophils in auto-immunity.
Hydralazine induces myeloperoxidase and proteinase 3 anti-neutrophil cytoplasmic antibody vasculitis and leads to pulmonary renal syndrome.
Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls.
IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis.
Immunization with anti-neutrophil cytoplasmic antibody (ANCA) induces the production of mouse ANCA and perivascular lymphocyte infiltration.
Immunodiagnostic and pathophysiologic aspects of antineutrophil cytoplasmic antibodies in vasculitis.
Immunohistochemical characterization of granulomatosis with polyangiitis exhibiting spontaneous regression.
Impact of autoantibody glycosylation in autoimmune diseases.
In silico design, synthesis, and assays of specific substrates for proteinase 3: influence of fluorogenic and charged groups.
In vitro cytokine production and proliferation of T cells from patients with anti-proteinase 3- and antimyeloperoxidase-associated vasculitis, in response to proteinase 3 and myeloperoxidase.
Increased circulating levels of proteinase 3 in patients with anti-neutrophilic cytoplasmic autoantibodies-associated systemic vasculitis in remission.
Increased membrane expression of proteinase 3 during neutrophil adhesion in the presence of anti proteinase 3 antibodies.
Increased monocyte transcription of the proteinase 3 gene in small vessel vasculitis.
Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism.
Indirect immunofluorescence (IIF) of normal washed peripheral blood cells to demonstrate antineutrophil cytoplasmic antibodies (ANCA).
Induction of neutrophil responsiveness to myeloperoxidase antibodies by their exposure to supernatant of degranulated autologous neutrophils.
Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils.
Is There a Role for LAMP-2 Autoantibodies in Patients with Antineutrophil Cytoplasmic Antibody-associated Vasculitis?
Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice.
Linked help from bacterial proteins drives autoantibody production in small vessel vasculitis.
Maintenance of tolerance by regulation of anti-myeloperoxidase B cells.
Measuring circulating complement activation products in myeloperoxidase and proteinase 3 antineutrophil cytoplasmic antibody vasculitis.
Membrane proteinase 3 expression on resting neutrophils as a pathogenic factor in PR3-ANCA-associated vasculitis.
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Meta-analysis of myeloperoxidase G-463/A polymorphism in anti-neutrophil cytoplasmic autoantibody-positive vasculitis.
Mizoribine as a safe and effective combined maintenance therapy with prednisolone for anti-neutrophil cytoplasmic antibody-associated vasculitis in a hemodialysis patient.
Monitoring proteinase 3 antineutrophil cytoplasmic antibodies for detection of relapses in small vessel vasculitis.
Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis.
Neutrophil myeloperoxidase harbors distinct site-specific peculiarities in its glycosylation.
Neutrophil surface presentation of the anti-neutrophil cytoplasmic antibody-antigen proteinase 3 depends on N-terminal processing.
Neutrophil-activating potential of antineutrophil cytoplasm autoantibodies.
Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.
New insights into the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitis.
New selective peptidyl di(chlorophenyl) phosphonate esters for visualizing and blocking neutrophil proteinase 3 in human diseases.
New Therapeutic Targets in ANCA-associated Vasculitis.
Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene.
p-ANCA with myeloperoxidase antibodies and c-ANCA with proteinase 3 antibodies define a different vasculitis entity in patients with renal involvement.
Pathogenesis of ANCA-associated vasculitides.
Pathogenesis of ANCA-associated vasculitis.
Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention.
Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis.
Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides.
Performance evaluation of three assays for the detection of PR3-ANCA in granulomatosis with polyangiitis in daily practice.
Positive classic antineutrophil cytoplasmic antibody (C-ANCA) titer at switch to azathioprine therapy associated with relapse in proteinase 3-related vasculitis.
Post-infectious acute glomerulonephritis with vasculitis and pulmonary hemorrhage.
PR3 antibodies do not induce renal pathology in a novel PR3-humanized mouse model for Wegener's granulomatosis.
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Propylthiouracil-Induced Vasculitis With Alveolar Hemorrhage Confirmed by Clinical, Laboratory, Computed Tomography, and Bronchoscopy Findings: A Case Report and Literature Review.
Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells.
Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis.
Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis.
Proteinase 3: the odd one out that became an autoantigen.
Proteomic analysis of neutrophils in ANCA-associated vasculitis reveals a dysregulation in proteinase 3-associated proteins such as annexin-A1 involved in apoptotic cell clearance.
Re-evaluation of 129 patients with systemic necrotizing vasculitides by using classification algorithm according to consensus methodology.
Reactivity against Complementary Proteinase-3 Is Not Increased in Patients with PR3-ANCA-Associated Vasculitis.
Regulation of macrophage activation by proteins expressed on apoptotic neutrophils: subversion towards autoimmunity by proteinase 3.
Restriction in V kappa gene use and antigen selection in anti-myeloperoxidase response in mice.
Review article: The role of CD4(+) T cells in ANCA-associated systemic vasculitis.
Rituximab for refractory Wegener's granulomatosis.
Rituximab in the treatment of refractory scleritis in patients with granulomatosis with polyangiitis (Wegener's).
S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies.
Saint John on Patmos: Revelations of the Role of Antineutrophil Cytoplasmic Antibody (ANCA) in Vasculitis.
Severe pulmonary emphysema in a young patient with vasculitis associated with proteinase-3 anti-neutrophil cytoplasmic antibodies (PR3-ANCA).
Should proteinase 3 and myeloperoxidase antineutrophil cytoplasmic antibody vasculitis be treated differently: part 1.
Should proteinase-3 and myeloperoxidase-anti-neutrophil cytoplasmic antibody vasculitis be treated differently: part 2.
Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls.
Staphylococcus aureus and Wegener's granulomatosis.
Structure of the azurocidin, proteinase 3, and neutrophil elastase genes. Implications for inflammation and vasculitis.
Structures of human proteinase 3 and neutrophil elastase--so similar yet so different.
Surgical Treatment of Symptomatic Aortic Aneurysm in a Patient with Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis: Case Report and Review of the Literature.
The Diagnostic and Clinical Utility of Autoantibodies in Systemic Vasculitis.
The presence of membrane Proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558.
The role of monocytes in ANCA-associated vasculitides.
The use of small molecule high-throughput screening to identify inhibitors of the proteinase 3-NB1 interaction.
Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
Treatment of granulomatosis with polyangiitis (Wegener's).
Treatment with the purine synthesis inhibitor mizoribine for ANCA-associated renal vasculitis.
Trojan horses: drug culprits associated with antineutrophil cytoplasmic autoantibody (ANCA) vasculitis.
Twenty-eight years with antineutrophil cytoplasmic antibodies (ANCA): how to test for ANCA - evidence-based immunology?
Urinary CD4+ effector memory T cells reflect renal disease activity in antineutrophil cytoplasmic antibody-associated vasculitis.
Use of proteinase 3 purified by reverse phase HPLC to detect autoantibodies in systemic vasculitis.
Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy.
Vasculitis: clinical approach, pathophysiology and treatment.
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway.
[ANCA-associated vasculitis]
[Antineutrophil cytoplasmic antibodies and associated diseases.]
[Antineutrophil cytoplasmic antibodies in nonvasculitis diseases: clinical correlates and target antigens]
[Antineutrophilic cytoplasmic antibodies (ANCA) in inflammatory rheumatic diseases: immunodiagnostic and immunopathogenetic aspects]
[Are antineutrophil cytoplasmic antibodies pathogenic?]
[Classification of systemic vasculatides]
[Clinical and pathogenetic aspects of kidney damage associated with neutrophilic cytoplasm antibodies]
[Genetic risk factors for vasculitis].
[New insights into the pathogenesis of ANCA-positive vasculitides]
[Review article: Antineutrophil cytoplasmic antibody in small vessel vasculitis]
[The complement system in the pathogenesis of antineutrophil cytoplasm antibodies-associated vasculitis].
[Wegener's granulomatosis with anti-neutrophil cytoplasmic antibodies against anti-cathepsin G antigen.]
Vasculitis, Leukocytoclastic, Cutaneous
Antineutrophil cytoplasmic antibody (ANCA)-positive cutaneous leukocytoclastic vasculitis induced by propylthiouracil confirmed by positive patch test: a case report and review of the literature.
Virus Diseases
Clinical interpretation of antineutrophil cytoplasmic antibodies: parvovirus B19 infection as a pitfall.
Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection.
Vitiligo
Vitiligo: a possible model of degenerative diseases.
Wilms Tumor
Anti-leukemia T cells in AML: TNF-?(+) CD8(+) T cells may escape detection and possibly reflect a stage of functional impairment.
Antigen-specific cellular immunotherapy of leukemia.
Cancer vaccines for patients with acute myeloid leukemia--definition of leukemia-associated antigens and current clinical protocols targeting these antigens.
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.
Clinical peptide vaccination trials for leukemia patients.
Dendritic cells generated from acute myeloid leukemia (AML) blasts maintain the expression of immunogenic leukemia associated antigens.
Immunotherapeutic strategies in chronic myeloid leukemia.
Longitudinal analyses of leukemia-associated antigen-specific CD8(+) T cells in patients after allogeneic stem cell transplantation.
Natural T cell immunity against cancer.
Peptide vaccines for myeloid leukaemias.
Peptide vaccines for patients with acute myeloid leukemia.
Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909.
Translational mini-review series on vaccines: Peptide vaccines for myeloid leukaemias.