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Disease on EC 3.4.21.75 - Furin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Missed
Distribution of furin, TNF-?, and TGF-?2 in the endometrium of missed abortion and voluntary first trimester termination cases.
Acute Kidney Injury
Hemojuvelin Modulates Iron Stress During Acute Kidney Injury: Improved by Furin Inhibitor.
Acute Lung Injury
Leukocyte ADAM17 regulates acute pulmonary inflammation.
adam 17 endopeptidase deficiency
Short-term TNF? shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.
Adenocarcinoma
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.
Adenocarcinoma of Lung
Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis.
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer.
Adenoma
Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas.
Adenoma, Acidophil
A Case of acromegaly associated with subclinical Cushing's disease.
Alzheimer Disease
A ratiometric electrochemical strategy for sensitive determination of Furin activity based on dual signal amplification and antifouling nanosurfaces.
Familial British dementia: colocalization of furin and ABri amyloid.
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Prediction of proprotein convertase cleavage sites.
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster.
The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve.
Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
Amyloidosis
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
The role of gelsolin domain 3 in familial amyloidosis (Finnish type).
Amyloidosis, Familial
Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization.
Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type.
Pathological and functional amyloid formation orchestrated by the secretory pathway.
The role of gelsolin domain 3 in familial amyloidosis (Finnish type).
Anemia
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Anovulation
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Anthrax
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.
A urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types.
Anthrax toxin component, Protective Antigen, protects insects from bacterial infections.
Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.
Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: A putative mechanism to overcome a furin deficiency.
Cross-inhibition of pathogenic agents and the host proteins they exploit.
Dissecting the urokinase activation pathway using urokinase-activated anthrax toxin.
Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension.
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen.
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Imaging specific cell surface protease activity in living cells using reengineered bacterial cytotoxins.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication.
Latent cytokines: development of novel cleavage sites and kinetic analysis of their differential sensitivity to MMP-1 and MMP-3.
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Modeling the activity of furin inhibitors using artificial neural network.
Novel Furin Inhibitors with Potent Anti-infectious Activity.
Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells.
Potent antitumor activity of a urokinase-activated engineered anthrax toxin.
Prediction of proprotein convertase cleavage sites.
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.
Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine.
Recent Developments in Anti-dotes Against Anthrax.
Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein.
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.
Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing.
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.
Aortic Valve Stenosis
Distinct downregulation of C-type natriuretic peptide system in human aortic valve stenosis.
Arthritis
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Protective role of systemic furin in immune response-induced arthritis.
Arthritis, Rheumatoid
Increased expression of the proprotein convertase enzyme FURIN in rheumatoid arthritis.
Increased FURIN expression in rheumatoid arthritis patients and its anti-inflammatory effect.
Inhibition of furin results in increased growth, invasiveness and cytokine production of synoviocytes from patients with rheumatoid arthritis.
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Asthma
A potential new target for asthma therapy: A Disintegrin and Metalloprotease 10 (ADAM10) involvement in murine experimental asthma.
ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma.
Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
Astrocytoma
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.
Atherosclerosis
A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis.
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.
Hepatic overexpression of the prodomain of furin lessens progression of atherosclerosis and reduces vascular remodeling in response to injury.
Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis.
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets.
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels.
Proprotein convertases in atherogenesis.
Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.
Autoimmune Diseases
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
The Role of Proprotein Convertases in the Regulation of the Function of Immune Cells in the Oncoimmune Response.
Autoimmune Hypophysitis
Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.
Bacterial Infections
Chemical structure and properties of low-molecular furin inhibitors.
Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer.
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
Why All the Fury over Furin?
[Furin and its biological role]
Bone Resorption
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Borna Disease
Processing of the Borna disease virus glycoprotein gp94 by the subtilisin-like endoprotease furin.
Brain Ischemia
Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA.
Brain Neoplasms
Opposite roles of furin and PC5A in N-cadherin processing.
Breast Neoplasms
ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties.
Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway.
Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases.
Elevated expression of proprotein convertases alters breast cancer cell growth in response to estrogen and tamoxifen.
Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway.
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels' Activation in Breast Cancer Cells.
Furin-instructed aggregated gold nanoparticles for re-educating tumor associated macrophages and overcoming breast cancer chemoresistance.
Identification of ADAM10 as a Major Source of HER2 Ectodomain Sheddase Activity in HER2 Overexpressing Breast Cancer Cells.
In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates.
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.
Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation.
Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.
Pro-protein convertase gene expression in human breast cancer.
Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor.
Targeted therapy in breast cancer: what's new?
The proprotein convertase furin in tumour progression.
Bronchitis
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection.
Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells.
CADASIL
Functional analysis of a recurrent missense mutation in Notch3 in CADASIL.
Carcinogenesis
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Heparan sulfate regulates ADAM12 through a molecular switch mechanism.
Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface.
Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins.
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
MMTV-cre-mediated fur inactivation concomitant with PLAG1 proto-oncogene activation delays salivary gland tumorigenesis in mice.
Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging.
Pirfenidone inhibits TGF-beta expression in malignant glioma cells.
Sheddase Activity of Tumor Necrosis Factor-{alpha} Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer.
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
Carcinoid Tumor
Expression of prohormone convertase, PC2, in adrenocorticotropin-producing thymic carcinoid with elevated plasma corticotropin-releasing hormone.
Immunohistochemical expressions of prohormone convertase (PC)1/3 and PC2 in carcinoids of various organs.
Carcinoma
A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells.
A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation.
Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression.
Direct role of furin in mammalian prosomatostatin processing.
Effect of ultraviolet radiation on the expression of pp38MAPK and furin in human keratinocyte-derived cell lines.
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus.
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology.
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin.
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells.
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Proteolytic cleavage of glycoprotein B is dispensable for in vitro replication, but required for syncytium formation of pseudorabies virus.
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma.
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
The proprotein convertase furin in tumour progression.
The proteolytic processing of pro-platelet-derived growth factor-A at RRKR(86) by members of the proprotein convertase family is functionally correlated to platelet-derived growth factor-A-induced functions and tumorigenicity.
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis.
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
[Membrane type 1 matrix metalloproteinase (MT1-MMP) and the regulators of its activity as invasive factors in squamous cell cervical carcinomas.]
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Carcinoma, Hepatocellular
Enzymatic inhibition of MICA sheddase ADAM17 by lomofungin in hepatocellular carcinoma cells.
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Polyphenols with indirect proprotein convertase inhibitory activity.
Regulated production of mature insulin by non-beta-cells.
Suppression of furin by interferon-? and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes.
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Carcinoma, Non-Small-Cell Lung
Proprotein convertase furin in SARS-CoV-2 and non-small cell lung cancer.
Carcinoma, Renal Cell
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Carcinoma, Squamous Cell
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression.
Effect of ultraviolet radiation on the expression of pp38MAPK and furin in human keratinocyte-derived cell lines.
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology.
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Structural variations and expression profiles of the SARS-CoV-2 host invasion genes in lung cancer.
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
The proprotein convertase furin in tumour progression.
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Cardiomyopathies
RNA sequencing analysis and atrial natriuretic Peptide production in patients with dilated and ischemic cardiomyopathy.
Cardiovascular Diseases
Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets.
Chikungunya Fever
Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.
Cholera
Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide.
Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice.
Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system.
The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor.
Choriocarcinoma
FURIN and placental syncytialisation: a cautionary tale.
The (pro)renin receptor and soluble (pro)renin receptor in choriocarcinoma.
The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization.
The proprotein convertase furin is required for trophoblast syncytialization.
Choroidal Neovascularization
A Sema3C Mutant Resistant to Cleavage by Furin (FR-Sema3C) Inhibits Choroidal Neovascularization.
Coinfection
Production and characterization of simian--human immunodeficiency virus-like particles.
Proparathyroid hormone processing by the proprotein convertase-7: comparison with furin and assessment of modulation of parathyroid convertase messenger ribonucleic acid levels by calcium and 1,25-dihydroxyvitamin D3.
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
Colitis
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.
Colitis, Ulcerative
Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway.
Colonic Neoplasms
Inactivation of proprotein convertases in T cells inhibits PD-1 expression and creates a favorable immune microenvironment in colorectal cancer.
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.
Colorectal Neoplasms
Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin ?-Sarcin- or RNase T1-Based Immunotoxins.
The proprotein convertase furin is a pro-oncogenic driver in KRAS and BRAF driven colorectal cancer.
Communicable Diseases
Elongated and Shortened Peptidomimetic Inhibitors of the Proprotein Convertase Furin.
Furin-mediated protein processing in infectious diseases and cancer.
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases.
Novel Furin Inhibitors with Potent Anti-infectious Activity.
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Therapeutic uses of furin and its inhibitors: a patent review.
Coronary Artery Disease
FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease-Associated Genetic Variant and Influences Monocyte Transendothelial Migration.
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice.
Platelet Activation and Plasma Levels of Furin Are Associated With Prognosis of Patients With Coronary Artery Disease and COVID-19.
Coronavirus Infections
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation.
Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells.
Whole Genome Analysis and Targeted Drug Discovery Using Computational Methods and High Throughput Screening Tools for Emerged Novel Coronavirus (2019-nCoV).
COVID-19
A bird eye view on cystic fibrosis: An underestimated multifaceted chronic disorder.
A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells.
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
ACE2 and Furin Expressions in Oral Epithelial Cells Possibly Facilitate COVID-19 Infection via Respiratory and Fecal-Oral Routes.
ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19.
ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19.
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry.
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2-infected patients.
Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study.
COVID-19 and cancer: Sailing through the tides.
COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.
COVID-19 in Smokeless Tobacco Habitués: Increased Susceptibility and Transmission.
Cryo-EM structure of S-Trimer, a subunit vaccine candidate for COVID-19.
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Ephrin-A1 and the sheddase ADAM12 are upregulated in COVID-19.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection.
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patients.
Fibrinolysis influences SARS-CoV-2 infection in ciliated cells.
Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection.
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects.
Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension.
Furin: A Potential Therapeutic Target for COVID-19.
Genomic Feature Analysis of Betacoronavirus Provides Insights Into SARS and COVID-19 Pandemics.
How Do Enveloped Viruses Exploit the Secretory Proprotein Convertases to Regulate Infectivity and Spread?
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Increased mortality of COVID-19 infected diabetes patients: role of furin proteases.
Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers.
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19.
Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19.
Persistently Increased Systemic ACE2 Activity Is Associated With an Increased Inflammatory Response in Smokers With COVID-19.
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
Placental response to maternal SARS-CoV-2 infection.
Platelet Activation and Plasma Levels of Furin Are Associated With Prognosis of Patients With Coronary Artery Disease and COVID-19.
Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics.
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart.
Structure of Furin Protease Binding to SARS-CoV-2 Spike Glycoprotein and Implications for Potential Targets and Virulence.
Synergy of melanin and vitamin-D may play a fundamental role in preventing SARS-CoV-2 infections and halt COVID-19 by inactivating furin protease.
The conundrum of using hyperoxia in COVID-19 treatment strategies: may intermittent therapeutic hyperoxia play a helpful role in the expression of the surface receptors ACE2 and Furin in lung tissue via triggering of HIF-1??
The effect of coronaviruses on olfaction: systematic review.
The Polybasic Cleavage Site in SARS-CoV-2 Spike Modulates Viral Sensitivity to Type I Interferon and IFITM2.
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
The role of high cholesterol in age-related COVID19 lethality.
Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells.
Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site.
Why All the Fury over Furin?
[Mechanism of QingfeiPaidu decoction for treatment of COVID-19: analysis based on network pharmacology and molecular docking technology].
Creutzfeldt-Jakob Syndrome
TREM2 expression in the brain and biological fluids in prion diseases.
Cystic Fibrosis
Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity.
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Dementia
Familial British dementia: colocalization of furin and ABri amyloid.
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Dengue
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
Dengue virus capsid anchor modulates the efficiency of polyprotein processing and assembly of viral particles.
Differential modulation of prM cleavage, extracellular particle distribution, and virus infectivity by conserved residues at nonfurin consensus positions of the dengue virus pr-M junction.
Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.
Enhancing dengue virus maturation using a stable furin over-expressing cell line.
Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Luteolin restricts dengue virus replication through inhibition of the proprotein convertase furin.
Obstruction of dengue virus maturation by Fab fragments of the 2H2 antibody.
Optimization of Substrate-Analogue Furin Inhibitors.
Structure of the immature dengue virus at low pH primes proteolytic maturation.
Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates.
Diabetes Mellitus
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular complications in type 2 diabetes mellitus patients.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
Topical GDF11 accelerates skin wound healing in both type 1 and 2 diabetic mouse models.
Diabetes Mellitus, Type 2
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
Diagnostic utility of BNP, corin and furin as biomarkers for cardiovascular complications in type 2 diabetes mellitus patients.
Diphtheria
A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro.
A role for PACE4 in the proteolytic activation of anthrax toxin protective antigen.
A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts.
Anti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells.
Evidence for involvement of furin in cleavage and activation of diphtheria toxin.
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing.
Novel Furin Inhibitors with Potent Anti-infectious Activity.
Pseudomonas exotoxin exhibits increased sensitivity to furin when sequences at the cleavage site are mutated to resemble the arginine-rich loop of diphtheria toxin.
Recombinant immunoproapoptotic proteins with furin site can translocate and kill HER2-positive cancer cells.
The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells.
Dry Eye Syndromes
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Ectodermal Dysplasia 1, Anhidrotic
Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia.
Encephalitis
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression.
Encephalitis, Tick-Borne
Proteolytic activation of tick-borne encephalitis virus by furin.
Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus.
Encephalomyelitis, Venezuelan Equine
Antibody to the E3 Glycoprotein Protects Mice Against Lethal Venezuelan Equine Encephalitis.
Endometrial Neoplasms
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
The significance of post-translational removal of ?-DG-N in early stage endometrial cancer development.
Endometriosis
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.
Epilepsy
Implications of the subtilisin/kexin-like precursor convertases in the development and function of nervous tissues.
Transgenic overexpression of furin increases epileptic susceptibility.
Essential Hypertension
Associations between genetic variations in the FURIN gene and hypertension.
Exocrine Pancreatic Insufficiency
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Fetal Growth Retardation
Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
Foot-and-Mouth Disease
Co-expression of self-cleaved multiple proteins derived from Porcine Reproductive and Respiratory Syndrome Virus by bi-cistronic and tri-cistronic DNA vaccines.
Recombinant AAV Vectors for Enhanced Expression of Authentic IgG.
Fraser Syndrome
Establishment of proprotein convertase, furinA knocked-out lines in medaka, Oryzias latipes, and unique form of medaka furin-like prorprotein convertase (mflPC).
Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes.
furin deficiency
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: A putative mechanism to overcome a furin deficiency.
Deficient serum furin predicts risk of abdominal obesity: findings from a prospective cohort of Chinese adults.
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic ? Cells of Mice.
Furin deficiency in myeloid cells leads to attenuated revascularization in a mouse-model of oxygen-induced retinopathy.
Gastrinoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Gingivitis
[Comparative clinical results in the treatment of gingivitis catarrhalis chronica with Furin M, applied by a tray for retention of the drug and by mouth rinsing]
Glioblastoma
Inhibition of furin-mediated processing results in suppression of astrocytoma cell growth and invasiveness.
Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin.
Glioma
?1,6 GlcNAc branches-modified protein tyrosine phosphatase Mu attenuates its tyrosine phosphatase activity and promotes glioma cell migration through PLC?-PKC pathways.
Opposite roles of furin and PC5A in N-cadherin processing.
Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases.
Glucose Intolerance
Proprotein convertase furin regulates osteocalcin and bone endocrine function.
Head and Neck Neoplasms
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.
Sheddase Activity of Tumor Necrosis Factor-{alpha} Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer.
Heart Failure
Differential expression of the pro-natriuretic peptide convertases corin and furin in experimental heart failure and atrial fibrosis.
Post-transcriptional modification of pro-BNP in heart failure: is glycosylation and circulating furin key for cardiovascular homeostasis?
Post-translational modifications enhance NT-proBNP and BNP production in acute decompensated heart failure.
Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites.
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
Hemochromatosis
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Hemophilia A
Circumventing furin enhances factor VIII biological activity and ameliorates bleeding phenotypes in hemophilia models.
Novel factor VIII variants with a modified furin cleavage site improve the efficacy of gene therapy for hemophilia A.
Stable expression of native Coagulation factor VIII using the 2A self-processing sequence and furin cleavage site.
Hemorrhagic Fever, Crimean
Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin.
Hemorrhagic Fever, Ebola
Ebola virus envelope glycoprotein derived peptide in human Furin-bound state: computational studies.
Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture.
Hepatitis
Cleavage inhibition of the murine coronavirus spike protein by a furin-like enzyme affects cell-cell but not virus-cell fusion.
Hepatitis B
Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme.
Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion.
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease.
Proteolytic processing of the hepatitis B virus e antigen precursor. Cleavage at two furin consensus sequences.
Suppression of furin by interferon-? and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes.
Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.
[Hepatitis B virus-mediated effects on host expression of the proprotein convertase Furin].
Hepatitis B, Chronic
Entecavir combined with furin inhibitor simultaneously reduces hepatitis B virus replication and e antigen secretion.
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
Hepatitis C
Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-?1: Role of TGF-?1 in HCV replication.
Hereditary Sensory and Autonomic Neuropathies
A third HSAN5 mutation disrupts the nerve growth factor furin cleavage site.
Herpes Zoster
Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice.
Extreme positive selection on a new highly-expressed larval glycoprotein (LGP) gene in Galaxias fishes (Osmeriformes: Galaxiidae).
Mouse zona pellucida glycoproteins mZP2 and mZP3 undergo carboxy-terminal proteolytic processing in growing oocytes.
Proteolytic processing of human zona pellucida proteins.
The Human Egg's Zona Pellucida.
HIV Infections
Soluble T Cell Immunoglobulin Mucin Domain 3 Is Shed from CD8+ T Cells by the Sheddase ADAM10, Is Increased in Plasma during Untreated HIV Infection, and Correlates with HIV Disease Progression.
Hodgkin Disease
Role of ADAM10 as a CD30 Sheddase in Classical Hodgkin Lymphoma.
Specific ADAM10 inhibitors localize in exosome-like vesicles released by Hodgkin lymphoma and stromal cells and prevent sheddase activity carried to bystander cells.
Huntington Disease
Decreased hypothalamic prohormone convertase expression in huntington disease patients.
Hypercholesterolemia
[Relationship between genetic variation of furin gene and hypercholesterolemia and hyper-low-density lipoprotein cholesterolemia in Kazakh general population].
Hyperkalemia
How SARS-CoV-2 might affect potassium balance via impairing epithelial sodium channels?
Hypertension
Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population.
Associations between genetic variations in the FURIN gene and hypertension.
Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension.
FURIN variant associations with postexercise hypotension are intensity and race dependent.
Identification of Hub Genes Associated with Hypertension and Their Interaction with miRNA Based on Weighted Gene Coexpression Network Analysis (WGCNA) Analysis.
Serum furin as a biomarker of high blood pressure: findings from a longitudinal study in Chinese adults.
The association between paired basic amino acid cleaving enzyme 4 gene haplotype and diastolic blood pressure.
Hyperthyroidism
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
Hypertriglyceridemia
Association of genetic variants with dyslipidemia.
Hypoglycemia
A case of prohormone convertase deficiency diagnosed with type 2 diabetes.
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
Hypophosphatemia
Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia.
Infections
A fusion-loop antibody enhances the infectious properties of immature flavivirus particles.
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro.
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins.
Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus.
ACE2 and Furin Expressions in Oral Epithelial Cells Possibly Facilitate COVID-19 Infection via Respiratory and Fecal-Oral Routes.
Alpha-Defensin HD5 Inhibits Furin Cleavage of Human Papillomavirus 16 L2 To Block Infection.
Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2.
Bioinformatics prediction of B and T cell epitopes within the spike and nucleocapsid proteins of SARS-CoV2.
Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong.
Blockage of Filoviral Glycoprotein Processing by Use of a Protein-Based Inhibitor.
Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves.
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection.
Cleavage and serum reactivity of the severe acute respiratory syndrome coronavirus spike protein.
Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection.
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection.
Common genetic variation in humans impacts in vitro susceptibility to SARS-CoV-2 infection.
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection.
Direct role of furin in mammalian prosomatostatin processing.
Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis.
Efficient delivery of DNA vaccines using human papillomavirus pseudovirions.
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses.
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Furin is an endogenous regulator of alpha-secretase associated APP processing.
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Genetic Control of Human Infection with SARS-CoV-2.
Heparan sulfate-independent cell binding and infection with furin-precleaved papillomavirus capsids.
Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Impact of inhibitors and L2 antibodies upon the infectivity of diverse alpha and beta human papillomavirus types.
Increased susceptibility of SARS-CoV2 infection on oral cancer patients; cause and effects: An hypothesis.
Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection.
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin.
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection.
Preparation and properties of a papillomavirus infectious intermediate and its utility for neutralization studies.
Production of Furin-Cleaved Papillomavirus Pseudovirions and Their Use for In Vitro Neutralization Assays of L1- or L2-Specific Antibodies.
Proteolytic activation of tick-borne encephalitis virus by furin.
Proteolytic processing of human cytomegalovirus glycoprotein B (gpUL55) is mediated by the human endoprotease furin.
Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity.
Recombinant Sendai viruses expressing fusion proteins with two furin cleavage sites mimic the syncytial and receptor-independent infection properties of respiratory syncytial virus.
Role of prohormone convertases in the tissue-specific processing of proglucagon.
Saliva: What Dental Practitioners Should Know about the Role of This Biofluid in the Transmission and Diagnostic of SARS-CoV-2.
Shedding Light on COVID-19: ADAM17 the Missing Link?
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
Suppression of furin by interferon-? and the impact on hepatitis B virus antigen biosynthesis in human hepatocytes.
Targeted infection of endothelial cells by avian influenza virus A/FPV/Rostock/34 (H7N1) in chicken embryos.
Targeting host cell proteases to prevent SARS-CoV-2 invasion.
Tetraspanin CD9 affects HPV16 infection by modulating ADAM17 activity and the ERK signalling pathway.
The old but new: Can unfractioned heparin and low molecular weight heparins inhibit proteolytic activation and cellular internalization of SARS-CoV2 by inhibition of host cell proteases?
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum.
The role of furin in papillomavirus infection.
The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection.
Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.
Type-2 diabetes, a co-morbidity in Covid-19: does insulin signaling matter?
Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions.
X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
[Hepatitis B virus-mediated effects on host expression of the proprotein convertase Furin].
[Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].
[Study on a putative, proprotein convertase-cleaved product of HBV core protein in vitro].
Infertility
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Infertility, Female
Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice.
Inflammatory Bowel Diseases
High Expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a Sheddase for TNF-? in the Mucosa of Patients with Inflammatory Bowel Diseases.
Influenza in Birds
A novel activation mechanism of avian influenza virus H9N2 by furin.
Combined QM/MM mechanistic study of the acylation process in furin complexed with the H5N1 avian influenza virus hemagglutinin's cleavage site.
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein.
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity.
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.
Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication.
Peptidomimetic furin inhibitor MI-701 in combination with oseltamivir and ribavirin efficiently blocks propagation of highly pathogenic avian influenza viruses and delays high level oseltamivir resistance in MDCK cells.
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones.
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Protein display by bovine herpesvirus type 1 glycoprotein B.
Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure.
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity.
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.
Source of high pathogenicity of an avian influenza virus H5N1: why H5 is better cleaved by furin.
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.
Two independent targeting signals in the cytoplasmic domain determine trans-Golgi network localization and endosomal trafficking of the proprotein convertase furin.
[Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].
Influenza, Human
A mono phenylalanine-based motif (F790) and a leucine-dependent motif (LI760) mediate internalization of furin.
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions.
Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin.
Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong.
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin.
Identification and characterization of spodoptera frugiperda furin: a thermostable subtilisin-like endopeptidase.
Implication of the proprotein convertases furin, PC5 and PC7 in the cleavage of surface glycoproteins of Hong Kong, Ebola and respiratory syncytial viruses: a comparative analysis with fluorogenic peptides.
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.
Optimization of furin inhibitors to protect against the activation of influenza hemagglutinin H5 and Shiga toxin.
Synthesis of tight binding inhibitors and their action on the proprotein-processing enzyme furin.
The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage : neurological Consequences of highly pathogenic Fujian H5N1 strains.
X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
[Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].
Insulin Resistance
Discovery of a possible role of asprosin in ovarian follicular function.
[Relationship between genetic variation of Furin and insulin resistance in Chinese Kazakh population].
Insulinoma
Biosynthesis of the prohormone convertase PC2 in Chinese hamster ovary cells and in rat insulinoma cells.
Isolation of two complementary deoxyribonucleic acid clones from a rat insulinoma cell line based on similarities to Kex2 and furin sequences and the specific localization of each transcript to endocrine and neuroendocrine tissues in rats.
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.
Iron Deficiencies
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis.
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Iron Overload
Effect of iron overload on furin expression in wild-type and ?-thalassemic mice.
Hemojuvelin Modulates Iron Stress During Acute Kidney Injury: Improved by Furin Inhibitor.
Ischemic Attack, Transient
Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population.
Kidney Neoplasms
The significance of TRIP11 and T3 signalling pathway in renal cancer progression and survival of patients.
The transcription factor PAX2 regulates ADAM10 expression in renal cell carcinoma.
Laryngeal Neoplasms
Radiotherapy-associated Furin Expression and Tumor Invasiveness in Recurrent Laryngeal Cancer.
Leukemia
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival.
Artificially controlled aggregation of proteins and targeting in hematopoietic cells.
Furin cleavage of the Moloney murine leukemia virus Env precursor reorganizes the spike structure.
Furin cleavage potentiates the membrane fusion-controlling intersubunit disulfide bond isomerization activity of leukemia virus Env.
The cytoplasmic domain mediates localization of furin to the trans-Golgi network en route to the endosomal/lysosomal system.
Liver Neoplasms
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.
Lung Neoplasms
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Proprotein convertase furin in SARS-CoV-2 and non-small cell lung cancer.
Proprotein convertases: "master switches" in the regulation of tumor growth and progression.
Lupus Erythematosus, Systemic
Proprotein convertase enzyme FURIN is upregulated in primary Sjögren's syndrome.
Lymphoma
Stress immunity in lymphomas: mesenchymal cells as a target of therapy.
Malaria
Immunization against a merozoite sheddase promotes multiple invasion of red blood cells and attenuates Plasmodium infection in mice.
Molecular Determinants for Subcellular Trafficking of the Malarial Sheddase PfSUB2.
Molecular identification of a malaria merozoite surface sheddase.
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion.
Malaria, Falciparum
Molecular Determinants for Subcellular Trafficking of the Malarial Sheddase PfSUB2.
Malnutrition
Genetic regulatory subnetworks and key regulating genes in rat hippocampus perturbed by prenatal malnutrition: implications for major brain disorders.
Marfan Syndrome
Establishment of proprotein convertase, furinA knocked-out lines in medaka, Oryzias latipes, and unique form of medaka furin-like prorprotein convertase (mflPC).
Massive Hepatic Necrosis
Influences on hepatitis B virus replication by a naturally occurring mutation in the core gene.
Measles
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein.
Recombinant measles virus requiring an exogenous protease for activation of infectivity.
Melanoma
ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.
Cumulative influence of matrix metalloproteinase-1 and -2 in the migration of melanoma cells within three-dimensional type I collagen lattices.
Furin processing dictates ectodomain shedding of human FAT1 cadherin.
Furin Prodomain ppFurin Enhances Ca2+ Entry Through Orai and TRPC6 Channels' Activation in Breast Cancer Cells.
Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase.
Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
Mesothelioma
ADAM10 mediates malignant pleural mesothelioma invasiveness.
Metabolic Syndrome
A multicenter consensus: A role of furin in the endothelial tropism in obese patients with COVID-19 infection.
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Association of FURIN and ZPR1 polymorphisms with metabolic syndrome.
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.
Mouth Neoplasms
Increased susceptibility of SARS-CoV2 infection on oral cancer patients; cause and effects: An hypothesis.
Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression.
Multiple Sclerosis
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
Muscular Dystrophy, Duchenne
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.
Myocardial Infarction
Co-elevation of brain natriuretic peptide and proprotein-processing endoprotease furin after myocardial infarction in rats.
Elevated FURIN levels in predicting mortality and cardiovascular events in patients with acute myocardial infarction.
Role of miR-24, Furin, and Transforming Growth Factor-?1 Signal Pathway in Fibrosis After Cardiac Infarction.
Neoplasm Metastasis
A SEMA3E mutant resistant to cleavage by furins (UNCL-SEMA3E) inhibits choroidal neovascularization.
Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway.
Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis.
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
Role of c-Src activity in the regulation of gastric cancer cell migration.
Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
The mechanism of PDX in regulating cervical cancer HeLa cell proliferation and tumor formation.
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
[Effects of ?1-PDX, a furin inhibitor, on growth, invasion, and tumorigenicity of cervical cancer HeLa cells].
Neoplasms
A Case of acromegaly associated with subclinical Cushing's disease.
A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen.
A fine-needle aspiration-based protein signature discriminates benign from malignant breast lesions.
A Golgi-Targeting and Dual-Color "Turn-On" Probe for Spatially Precise Imaging of Furin.
A Novel TNF-? Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice.
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
A SEMA3E mutant resistant to cleavage by furins (UNCL-SEMA3E) inhibits choroidal neovascularization.
A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.
Aberrant ADAM10 expression correlates with osteosarcoma progression.
Activatable oligomerizable imaging agents for photoacoustic imaging of furin-like activity in living subjects.
ADAM-10 and ADAM-17 in the inflamed human CNS.
ADAM10 as a target for anti-cancer therapy.
ADAM10 mediates malignant pleural mesothelioma invasiveness.
ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.
ADAM17 at the interface between inflammation and autoimmunity.
ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding.
ADAM17 is a survival factor for microglial cells in vitro and in vivo after spinal cord injury in mice.
ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells.
ADAM28 is elevated in humans with the metabolic syndrome and is a novel sheddase of human tumour necrosis factor-?.
Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.
Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta.
An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model.
Anthrax toxin: structures, functions and tumour targeting.
Assessing experimental models in myocardial injury: Lack of activation of the proteases TACE and calpain in brief ischaemia and reperfusion.
Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS.
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89?Å resolution.
Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain.
Cancer/testis antigen-Plac1 promotes invasion and metastasis of breast cancer through Furin/NICD/PTEN signaling pathway.
Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy.
Cellular sheddases are induced by Merkel cell polyomavirus small tumour antigen to mediate cell dissociation and invasiveness.
Colorectal cancer cells express functional cell surface-bound TGFbeta.
Comparative analysis of expression of the proprotein convertases furin, PACE4, PC1 and PC2 in human lung tumours.
Construction and characterization of novel, recombinant immunotoxins targeting the Her2/neu oncogene product: in vitro and in vivo studies.
Control of spontaneous ovarian tumors by CD8+ T cells through NKG2D-targeted delivery of antigenic peptide.
Controlled intracellular self-assembly of gadolinium nanoparticles as smart molecular MR contrast agents.
COVID-19 and cancer: Sailing through the tides.
Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding.
Deciphering the Role of the ADAM17-Dependent Secretome in Cell Signaling.
Decreased TNF Levels and Improved Retinal Ganglion Cell Survival in MMP-2 Null Mice Suggest a Role for MMP-2 as TNF Sheddase.
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.
Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice.
Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.
Distribution and colocalization of cholecystokinin with the prohormone convertase enzymes PC1, PC2, and PC5 in rat brain.
Ectodomain shedding of furin: kinetics and role of the cysteine-rich region.
ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation.
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Endoproteolysis of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme) within its catalytic domain. A potential mechanism for regulation.
Endoproteolytic processing of proopiomelanocortin and prohormone convertases 1 and 2 in neuroendocrine cells overexpressing prohormone convertases 1 or 2.
Engineering of ?1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis.
Engineering of alpha1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: importance of the P2' residue in stable complex formation of the serpin with proprotein convertase.
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
Enzyme-instructed self-aggregation of Fe3O4 nanoparticles for enhanced MRI T2 imaging and photothermal therapy of tumors.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation.
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Establishment of an MT4-MMP-deficient mouse strain representing an efficient tracking system for MT4-MMP/MMP-17 expression in vivo using beta-galactosidase.
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
Expression of the prohormone convertase PC2 correlates with the presence of corticotropin-like intermediate lobe peptide in human adrenocorticotropin-secreting tumors.
Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis.
Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1.
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors.
Furin expression in squamous cell carcinomas of the oral cavity and other sites evaluated by tissue microarray technology.
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Furin inhibitor D6R suppresses epithelial-mesenchymal transition in SW1990 and PaTu8988 cells via the Hippo-YAP signaling pathway.
Furin is involved in uterine activation for labor.
Furin mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation.
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model.
Furin-mediated processing of Pro-C-type natriuretic peptide.
Furin-mediated protein processing in infectious diseases and cancer.
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial.
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Human furin Cys198 imposes dihedral and positional restraints on His194 for optimal Ser386-proton transfer.
Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface.
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Immunohistochemical expressions of prohormone convertase (PC)1/3 and PC2 in carcinoids of various organs.
Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib.
Implications of Proprotein Convertases in Ovarian Cancer Cell Proliferation and Tumor Progression: Insights for PACE4 as a Therapeutic Target.
In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17-mediated tumor necrosis factor alpha production.
In Situ Imaging of Furin Activity with a Highly Stable Probe by Releasing of Precipitating Fluorochrome.
In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates.
Inactivation of proprotein convertases in T cells inhibits PD-1 expression and creates a favorable immune microenvironment in colorectal cancer.
Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin ?-Sarcin- or RNase T1-Based Immunotoxins.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells.
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.
Inhibition of furin results in increased growth, invasiveness and cytokine production of synoviocytes from patients with rheumatoid arthritis.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules.
Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor.
Inhibition of processing of parathyroid hormone-related peptide by anti-sense furin: effect in vitro and in vivo on rat Leydig (H-500) tumor cells.
Inhibition of Tumor Cells Proliferation and Migration by the Flavonoid Furin Inhibitor Isolated From Oroxylum indicum.
Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.
Inhibitory role of TACE/ADAM17 cytotail in protein ectodomain shedding.
Interleukin-33 is a Novel Immunosuppressor that Protects Cancer Cells from TIL Killing by a Macrophage-Mediated Shedding Mechanism.
Intracellular Disassembly of Self-Quenched Nanoparticles Turns NIR Fluorescence on for Sensing Furin Activity in Cells and in Tumors.
L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas.
Limited redundancy of the proprotein convertase furin in mouse liver.
Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in vitro morphogenesis.
Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site.
Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression.
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution.
MT1-MMP mediates MUC1 shedding independent of TACE/ADAM17.
Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging.
Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase.
One-step 18F-fluorination of smart positron emission tomography tracer for sensing furin activity in tumors.
p38 Kinase is Crucial for Osteopontin-induced Furin Expression that Supports Cervical Cancer Progression.
PACE4 is an important driver of ZR-75-1 estrogen receptor-positive breast cancer proliferation and tumor progression.
Pan-Cancer Analysis of FURIN as a Potential Prognostic and Immunological Biomarker.
Phase II study of Vigil® DNA engineered immunotherapy as maintenance in advanced stage ovarian cancer.
Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality.
Polyarginines are potent furin inhibitors.
Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression.
Post-translational processing of proopiomelanocortin (POMC) in mouse pituitary melanotroph tumors induced by a POMC-simian virus 40 large T antigen transgene.
Potent inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin: Implications for broad anti-tumor efficacy.
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.
Prediction of proprotein convertase cleavage sites.
Pro-protein convertase gene expression in human breast cancer.
Processing of CD109 by furin and its role in the regulation of TGF-beta signaling.
Prodomain of the proprotein convertase subtilisin/kexin Furin (ppFurin) protects from tumor progression and metastasis.
Proprotein convertases in post-menopausal endometrial cancer: Distinctive regulation and non-invasive diagnosis.
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Protection of the Furin Cleavage Site in Low-Toxicity Immunotoxins Based on Pseudomonas Exotoxin A.
Proteolytic processing activates a viral superantigen.
Proteolytic processing of pro-opiomelanocortin occurs in acidifying secretory granules of AtT-20 cells.
Radiotherapy-associated Furin Expression and Tumor Invasiveness in Recurrent Laryngeal Cancer.
Reactive oxygen species mediate tumor necrosis factor alpha-converting, enzyme-dependent ectodomain shedding induced by phorbol myristate acetate.
Recombinant immunoproapoptotic proteins with furin site can translocate and kill HER2-positive cancer cells.
Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.
Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer.
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Role of proprotein convertases in prostate cancer progression.
Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence.
Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.
Self-Assembly of Amphiphilic Peptides for Recognizing High Furin-Expressing Cancer Cells.
Sheddase Activity of Tumor Necrosis Factor-{alpha} Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer.
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.
Soluble Form of the (Pro)Renin Receptor Generated by Intracellular Cleavage by Furin Is Secreted in Plasma.
Substitution of methionine 435 with leucine, isoleucine, and serine in tumor necrosis factor alpha converting enzyme inactivates ectodomain shedding activity.
Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor.
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
TACE (ADAM17) inhibits Schwann cell myelination.
TACE in perinatal mouse lung epithelial cells promotes lung saccular formation.
TACE/ADAM17 Mediates Mechanotransduction in Murine Tracheal Epithelial Cells.
Targeted Coating With Antigenic Peptide Renders Tumor Cells Susceptible to CD8(+) T Cell-mediated Killing.
Targeted delivery of activatable fluorescent probe for detection of furin activity in living cells.
Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype.
Targeting ADAM17 Sheddase Activity In Cancer.
Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin.
Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth.
Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
The growth hormone receptor interacts with its sheddase, the tumour necrosis factor-alpha-converting enzyme (TACE).
The mechanism of PDX in regulating cervical cancer HeLa cell proliferation and tumor formation.
The membrane-proximal domain of ADAM17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
The proprotein convertase furin in tumour progression.
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells.
The proprotein convertase PC5/6 is protective against intestinal tumorigenesis: in vivo mouse model.
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum.
The proprotein convertases furin and PACE4 play a significant role in tumor progression.
Therapeutic potential of TACE inhibitors in stroke.
Therapeutic uses of furin and its inhibitors: a patent review.
Thyroid hormone promotes cell invasion through activation of furin expression in human hepatoma cell lines.
TNF-alpha converting enzyme (TACE) protein expression in different clinical subtypes of multiple sclerosis.
TNF?-Erk1/2 signaling pathway-regulated SerpinE1 and SerpinB2 are involved in lipopolysaccharide-induced porcine granulosa cell proliferation.
Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression.
Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.
Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin.
Tumor imaging using radiolabelled matrix metalloproteinase-activated anthrax proteins.
Tumor Necrosis Factor-? Converting Enzyme (TACE) Is a Growth Hormone Binding Protein (GHBP) Sheddase: The Metalloprotease TACE/ADAM-17 Is Critical for (PMA-Induced) GH Receptor Proteolysis and GHBP Generation.
Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation.
Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation.
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
Tumor necrosis factor-alpha processing inhibitor-1 inhibits skin fibrosis in a bleomycin-induced murine model of scleroderma.
Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17.
Tumour necrosis factor (TNF-alpha) alpha converting enzyme and soluble TNF-alpha receptor type 1 in psoriasis patients in relation to the chronic alcohol consumption.
Upregulation of ADAM-17 expression in active lesions in multiple sclerosis.
X-ray Structures of Human Furin in Complex with Competitive Inhibitors.
[Generation and characterization of the adult neuron-specific ADAM10 knock-out mice].
[Tissue collagenase MMP-14 and endogenous regulators of its activity in the corpus uteri in squamous cell carcinoma of the cervix].
Nervous System Diseases
FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs.
Neuralgia
Effect of recombinant adenovirus coding for endomorphin-2 on neuropathic pain in rats.
Neuroblastoma
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.
Proteolytic processing of chromogranin A by the prohormone convertase PC2.
Neurodegenerative Diseases
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration.
[Furin as proprotein convertase and its role in normaland pathological biological processes].
Neuroinflammatory Diseases
Gallic Acid is a Dual ?/?-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice.
HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.
Newcastle Disease
Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts.
Non-alcoholic Fatty Liver Disease
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Pediatric Non-Alcoholic Fatty Liver Disease Is Affected by Genetic Variants Involved in Lifespan/Healthspan.
Obesity
A higher level of serum furin indicates a higher risk of microalbuminuria: results from a longitudinal study in Chinese adults.
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Common PCSK1 Haplotypes Are Associated With Obesity in the Chinese Population.
Deficient serum furin predicts risk of abdominal obesity: findings from a prospective cohort of Chinese adults.
Furin Protease: From SARS CoV-2 to Anthrax, Diabetes, and Hypertension.
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3.
Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization.
Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice.
Obesity--a genetic disease of adipose tissue?
Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity.
Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity.
Rare genetic forms of obesity: From gene to therapy.
Regulation of adipolin/CTRP12 cleavage by obesity.
The role of high cholesterol in age-related COVID19 lethality.
[Association between sequence variation of Furin gene and obesity in ethnic Kazakh from Xinjiang].
[Monogenic forms of obesity: from mice to human]
Obesity, Abdominal
Deficient serum furin predicts risk of abdominal obesity: findings from a prospective cohort of Chinese adults.
Olfaction Disorders
The effect of coronaviruses on olfaction: systematic review.
Osteoarthritis
Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGF?-dependent manner and limits osteoarthritis in mice.
Osteoporosis
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Osteosarcoma
A furin inhibitor downregulates osteosarcoma cell migration by downregulating the expression levels of MT1-MMP via the Wnt signaling pathway.
A novel recombinant immuno-tBid with a furin site effectively suppresses the growth of HER2-positive osteosarcoma cells in vitro.
Aberrant ADAM10 expression correlates with osteosarcoma progression.
Ovarian Neoplasms
ERBB3-induced furin promotes the progression and metastasis of ovarian cancer via the IGF1R/STAT3 signaling axis.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer.
Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers.
Proprotein convertase inhibition: Paralyzing the cell's master switches.
Overweight
Association between circulating furin levels, obesity and pro-inflammatory markers in children.
Pancreatic Neoplasms
A Soluble Form of the Giant Cadherin Fat1 Is Released from Pancreatic Cancer Cells by ADAM10 Mediated Ectodomain Shedding.
An Antibody Designed to Improve Adoptive NK-Cell Therapy Inhibits Pancreatic Cancer Progression in a Murine Model.
Furin promotes epithelial-mesenchymal transition in pancreatic cancer cells via Hippo-YAP pathway.
Methyl-CpG-binding protein 2 drives the Furin/TGF-?1/Smad axis to promote epithelial-mesenchymal transition in pancreatic cancer cells.
The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
Papillomavirus Infections
Alcohol metabolism by oral streptococci and interaction with human papillomavirus leads to malignant transformation of oral keratinocytes.
Furin Cleavage of L2 during Papillomavirus Infection: Minimal Dependence on Cyclophilins.
Heparan sulfate-independent cell binding and infection with furin-precleaved papillomavirus capsids.
Streptococcus endopeptidases promote HPV infection in vitro.
The role of furin in papillomavirus infection.
Paralysis
Mitochondrial dysfunction causes Ca2+ overload and ECM degradation-mediated muscle damage in C. elegans.
Paramyxoviridae Infections
A monomeric uncleaved respiratory syncytial virus F antigen retains prefusion-specific neutralizing epitopes.
Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host.
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones.
Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2.
Pemphigus
Pathogenic Epitopes of Autoantibodies in Pemphigus Reside in the Amino-Terminal Adhesive Region of Desmogleins Which Are Unmasked by Proteolytic Processing of Prosequence.
Perinatal Death
Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.
Periodontal Diseases
Oral cancer and periodontal disease increase the risk of COVID 19? A mechanism mediated through furin and cathepsin overexpression.
Periodontitis
COVID-19 and Periodontitis: A Reality to Live with.
Periodontal Diseases and COVID-19: A Scoping Review.
Persistent Infection
Furin mRNA expression in peripheral blood correlates with chronic hepatitis B virus infection.
The Proprotein Convertase Subtilisin/Kexin FurinA Regulates Zebrafish Host Response against Mycobacterium marinum.
Therapeutic potential of furin inhibitors for the chronic infection of hepatitis B virus.
Pheochromocytoma
Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66.
PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells.
Regulation of carboxypeptidase E by membrane depolarization in PC12 pheochromocytoma cells: comparison with mRNAs encoding other peptide- and catecholamine-biosynthetic enzymes.
Pituitary Diseases
Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.
Pituitary Neoplasms
Distribution and regulation of proconvertases PC1 and PC2 in human pituitary adenomas.
Frequent appearance of autoantibodies against prohormone convertase 1/3 and neuroendocrine protein 7B2 in patients with nonfunctioning pituitary macroadenoma.
Pneumonia
Bovine respiratory syncytial virus lacking the virokinin or with a mutation in furin cleavage site RA(R/K)R109 induces less pulmonary inflammation without impeding the induction of protective immunity in calves.
SARS-CoV-2 (COVID-19) and cystic fibrosis.
Polycystic Ovary Syndrome
Discovery of a possible role of asprosin in ovarian follicular function.
Post-Exercise Hypotension
FURIN variant associations with postexercise hypotension are intensity and race dependent.
Postural Orthostatic Tachycardia Syndrome
Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome.
Prader-Willi Syndrome
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.
Pre-Eclampsia
Altered serum soluble furin and prorenin receptor levels in pregnancies with pre-eclampsia and fetal growth restriction.
Prion Diseases
The sheddase ADAM10 is a potent modulator of prion disease.
TREM2 expression in the brain and biological fluids in prion diseases.
Prostatic Neoplasms
ALCAM/CD166 Is a TGF-?-Responsive Marker and Functional Regulator of Prostate Cancer Metastasis to Bone.
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
Proteinuria
The epithelial sodium channel ?-subunit is processed proteolytically in human kidney.
Psoriasis
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Expression of microRNA-21 and TIMP-3 in paradoxical psoriasiform reactions during treatment with antitumor necrosis factor agents.
Furin Expression in Patients With Psoriasis-A Patient Cohort Endangered to SARS-COV2?
Pulmonary Disease, Chronic Obstructive
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis.
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD.
Pulmonary Edema
Is Spironolactone the Preferred Renin-Angiotensin-Aldosterone Inhibitor for Protection Against COVID-19?
Rhabdomyosarcoma
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model.
The Proprotein Convertase Furin Contributes to Rhabdomyosarcoma Malignancy by Promoting Vascularization, Migration and Invasion.
The proprotein convertase furin in tumour progression.
Rhabdomyosarcoma, Alveolar
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells.
Rheumatic Diseases
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Sarcoma, Ewing
Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy.
Seizures
Pilocarpine-induced seizures are accompanied by a transient elevation in the messenger RNA expression of the prohormone convertase PC1 in rat hippocampus: comparison with nerve growth factor and brain-derived neurotrophic factor expression.
Sepsis
Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis.
Separating signal from noise: the challenge of identifying useful biomarkers in sepsis.
The Plasma Level of Proprotein Convertase FURIN in Patients with Suspected Infection in the Emergency Room: A Prospective Cohort Study.
Severe Acute Respiratory Syndrome
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis.
The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia.
The Science Underlying COVID-19: Implications for the Cardiovascular System.
Skin Neoplasms
Enhanced UV-Induced Skin Carcinogenesis in Transgenic Mice Overexpressing Proprotein Convertases.
T-cell-expressed proprotein convertase FURIN inhibits DMBA/TPA-induced skin cancer development.
Small Cell Lung Carcinoma
Prohormone convertase and autocrine growth factor mRNAs are coexpressed in small cell lung carcinoma.
Solitary Fibrous Tumors
Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia.
Somatostatinoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Spinal Cord Injuries
Gene expression alterations of neurotrophins, their receptors and prohormone convertases in a rat model of spinal cord contusion.
Squamous Cell Carcinoma of Head and Neck
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression.
Elevated furin expression in aggressive human head and neck tumors and tumor cell lines.
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells.
Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin.
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells.
Simultaneous expression of furin and vascular endothelial growth factor in human oral tongue squamous cell carcinoma progression.
Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation.
The proprotein convertase furin in tumour progression.
Stomach Neoplasms
Prohormone convertase furin has a role in gastric cancer cell proliferation with parathyroid hormone-related peptide in a reciprocal manner.
Role of c-Src activity in the regulation of gastric cancer cell migration.
Stroke
Microarray Data Analysis of Molecular Mechanism Associated with Stroke Progression.
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
Tachycardia
Proconvertase Furin Is Downregulated in Postural Orthostatic Tachycardia Syndrome.
Teratocarcinoma
CCK processing by pituitary GH3 cells, human teratocarcinoma cells NT2 and hNT differentiated human neuronal cells evidence for a differentiation-induced change in enzyme expression and pro CCK processing.
Thrombosis
Ibrutinib, but not zanubrutinib, induces platelet receptor shedding of GPIb-IX-V complex and integrin ?IIb?3 in mice and humans.
Thyroid Neoplasms
Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin-producing cell lines.
Toxemia
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.
Trauma, Nervous System
ADAM17-deficiency on microglia but not on macrophages promotes phagocytosis and functional recovery after spinal cord injury.
Triple Negative Breast Neoplasms
Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer.
Loss of the proprotein convertase Furin in T cells represses mammary tumorigenesis in oncogene-driven triple negative breast cancer.
Uterine Cervical Neoplasms
Identification of a Six-Gene Signature for Predicting the Overall Survival of Cervical Cancer Patients.
p38 Kinase is Crucial for Osteopontin-induced Furin Expression that Supports Cervical Cancer Progression.
[Effects of ?1-PDX, a furin inhibitor, on growth, invasion, and tumorigenicity of cervical cancer HeLa cells].
Vaccinia
Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin.
Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage.
Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.
Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases.
Characterization of a secreted form of human furin endoprotease.
Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways.
Comparison of substrate specificities against the fusion glycoprotein of virulent Newcastle disease virus between a chick embryo fibroblast processing protease and mammalian subtilisin-like proteases.
Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.
Direct role of furin in mammalian prosomatostatin processing.
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease.
Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.
Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.
Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.
Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study.
Proprotein processing activity and cleavage site selectivity of the Kex2-like endoprotease PACE4.
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.
Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations.
Sequence specificity of furin, a proprotein-processing endoprotease, for the hemagglutinin of a virulent avian influenza virus.
Stretch-induced hypertrophic growth of cardiocytes and processing of brain-type natriuretic peptide are controlled by proprotein-processing endoprotease furin.
The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity.
Vascular Diseases
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
Vascular System Injuries
Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels.
Vipoma
Proprotein-Processing Endoprotease Furin and its Substrate Parathyroid Hormone-Related Protein Are Coexpressed in Insulinoma Cells.
Viremia
The furin-S2' site in avian coronavirus plays a key role in central nervous system damage progression.
Virus Diseases
ACE2 expression is related to the interferon response in airway epithelial cells but is that functional for SARS-CoV-2 entry?
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection.
Design and Structure-Activity Relationship of a Potent Furin Inhibitor Derived from Influenza Hemagglutinin.
Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol.
Human microRNA-24 modulates highly pathogenic avian-origin H5N1 influenza A virus infection in A549 cells by targeting secretory pathway furin.
Identification of potent and compartment-selective small molecule furin inhibitors using cell-based assays.
Limited redundancy of the proprotein convertase furin in mouse liver.
SARS-CoV-2 (COVID-19) and cystic fibrosis.
Template-assisted rational design of peptide inhibitors of furin using the lysine fragment of the mung bean trypsin inhibitor.
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity.
The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes.
Vitiligo
The Ca2+-Binding Capacity of Epidermal Furin Is Disrupted by H2O2-Mediated Oxidation in Vitiligo.
West Nile Fever
The infectivity of prM-containing partially mature West Nile virus does not require the activity of cellular furin-like proteases.