Reference on EC 3.4.21.75 - Furin
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
eukaryota
Hatsuzawa, K.; Murakami, K.; Nakayama, K.
Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites
J. Biochem.
111
296-301
1992
Mus musculus
Denault, J.B.; Leduc, R.
Furin/PACE/SPC1: a convertase involved in exocytic and endocytic processing of precursor proteins
FEBS Lett.
379
113-116
1996
Homo sapiens
Nakayama, K.
Purification of recombinant soluble forms of furin produced in Chinese hamster ovary cells
Methods Enzymol.
244
167-175
1994
Mus musculus
Creemers, J.W.M.; Vey, M.; Schfer, W.; Ayoubi, T.A.Y.; Roebroek, A.J.M.; Klenk, H.D.; Garten, W.; van de Ven, W.J.M.
Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum
J. Biol. Chem.
270
2695-2702
1995
Bos taurus, Homo sapiens
Angliker, H.; Neumann, U.; Molloy, S.S.; Thomas, G.
Internally quenched fluorogenic substrate for furin
Anal. Biochem.
224
409-412
1995
Mammalia
Brennan, S.O.; Nakayama, K.
Cleavage of proalbumin peptides by furin reveals unexpected restrictions at the P2 and P1 sites
FEBS Lett.
347
80-84
1994
Mus musculus
Hatsuzawa, K.; Nagahama, M.; Takahashi, S.; Takada, K.; Murakami, K.; Nakayama, K.
Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells
J. Biol. Chem.
267
16094-16099
1992
Mus musculus
Molloy, S.S.; Bresnahan, P.A.; Leppla, S.H.; Klimpel, K.R.; Thomas, G.
Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen
J. Biol. Chem.
267
16396-16402
1992
Homo sapiens
Wuthrich, M.; Creemers, J.W.M.; van de Ven, W.J.M.; Sterchi, E.E.
Human lactase-phlorizin hydrolase is not processed by furin, PC1/PC3, PC2, PACE4 and PC5/PC6A of the family of subtilisin-like proprotein processing proteases
Biochim. Biophys. Acta
1311
199-203
1996
Homo sapiens
Jean, F.; Boudreault, A.; Basak, A.; Seidah, N.G.; Lazure, C.
Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor
J. Biol. Chem.
270
19225-19231
1995
Homo sapiens
Milhiet, P.E.; Chevallier, S.; Corbeil, D.; Seidah, N.G.; Boileau, G.
Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin
Biochem. J.
309
683-688
1995
Homo sapiens
Vidricaire, G.; Denault, J.B.; Leduc, R.
Characterization of a secreted form of human furin endoprotease
Biochem. Biophys. Res. Commun.
195
1011-1018
1993
Homo sapiens
Brakch, N.; Dettin, M.; Scarinci, C.; Seidah, N.G.; di Bello, C.
Structural investigation and kinetic characterization of potential cleavage sites of HIV GP160 by human furin and PC1
Biochem. Biophys. Res. Commun.
213
356-361
1995
Homo sapiens
Oda, K.; Misumi, Y.; Ikehara, Y.; Brennan, S.O.; Hatsuzawa, K.; Nakayama, K.
Proteolytic cleavages of proalbumin and complement Pro-C3 in vitro by a truncated soluble form of furin, a mammalian homologue of the yeast Kex2 protease
Biochem. Biophys. Res. Commun.
189
1353-1361
1992
Mus musculus
Rehemtulla, A.; Kaufman, R.J.
Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes
Blood
79
2349-2355
1992
Homo sapiens, Mammalia, Mus musculus
Brennan, S.O.; Nakayama, K.
Furin has the proalbumin substrate specificity and serpin inhibitory properties of an in situ hepatic convertase
FEBS Lett.
338
147-151
1994
Mus musculus
Jean, F.; Basak, A.; DiMaio, J.; Seidah, N.G.; Lazure, C.
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor
Biochem. J.
307
689-695
1995
Homo sapiens
Jean, F.; Basak, A.; Rondeau, N.; Benjannet, S.; Hendy, G.N.; Seidah, N.G.
Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells
Biochem. J.
292
891-900
1993
Homo sapiens, Mus musculus
Rufaut, N.W.; Brennan, S.O.; Hakes, D.J.; Dixon, J.E.; Birch, N.P.
Purification and characterization of the candidate prohormone-processing enzyme SPC3 produced in a mouse L cell line [published erratum appears in J Biol Chem 1994 Apr 29;269(17):13056]
J. Biol. Chem.
268
20291-20298
1993
Rattus norvegicus
Zhou, Y.; Lindberg, I.
Purification and characterization of the prohormone convertase PC1(PC3)
J. Biol. Chem.
268
5615-5623
1993
Mus musculus
Garten, W.; Hallenberger, S.; Ortmann, D.; Schaefer, W.; Vey, M.; Angliker, H.; Shaw, E.; Klenk, H.D.
Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones
Biochimie
76
217-225
1994
aves, Homo sapiens
Matthews, D.J.; Goodman, L.J.; Gorman, C.M.; Wells, J.A.
A survey of furin substrate specificity using substrate phage display
Protein Sci.
3
1197-1205
1994
Mammalia
Zhou, Y.; Lindberg, I.
Enzymatic properties of carboxyl-terminally truncated prohormone convertase 1 (PC1/SPC3) and evidence for autocatalytic conversion
J. Biol. Chem.
269
18408-18413
1994
eukaryota
Lindberg, I.; van den Hurk, W.H.; Bui, C.; Batie, C.J.
Enzymatic characterization of immunopurified prohormone convertase 2: potent inhibition by a 7B2 peptide fragment [published erratum appears in Biochemistry 1995 Jun 13;34(23):7780]
Biochemistry
34
5486-5493
1995
eukaryota
Dai, G.; Smeekens, S.P.; Steiner, D.F.; McMurtry, J.P.; Kwok, S.C.M.
Characterization of multiple prohormone convertase PC1/3 transcripts in porcine ovary
Biochim. Biophys. Acta
1264
1-6
1995
eukaryota
Azaryan, A.V.; Krieger, T.J.; Hook, V.Y.H.
Purification and characteristics of the candidate prohormone processing proteases PC2 and PC1/3 from bovine adrenal medulla chromaffin granules
J. Biol. Chem.
270
8201-8208
1995
eukaryota
Shennan, K.I.J.; Smeekens, S.P.; Steiner, D.F.; Docherty, K.
Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes
FEBS Lett.
284
277-280
1991
eukaryota
Bailyes, E.M.; Shennan, K.I.J.; Usac, E.F.; Arden, S.D.; Guest, P.C.; Docherty, K.; Hutton, J.C.
Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2
Biochem. J.
309
587-594
1995
eukaryota
Seidah, N.G.; Day, R.; Chretien, M.
The family of pro-hormone and pro-protein convertases
Biochem. Soc. Trans.
21
685-691
1993
Mammalia, Rattus norvegicus
Basak, A.; Lazure, C.
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes
Biochem. J.
373
231-239
2003
Homo sapiens
Komiyama, T.; Fuller, R.S.
Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin
Biochemistry
39
15156-15165
2000
Saccharomyces cerevisiae, Homo sapiens
Cieplik, M.; Klenk, H.D.; Garten, W.
Identification and characterization of spodoptera frugiperda furin: a thermostable subtilisin-like endopeptidase
Biol. Chem.
379
1433-1440
1998
Bos taurus, Spodoptera frugiperda (Q26489), Spodoptera frugiperda
Liu, Z.X.; Fei, H.; Chi, C.W.
Two engineered eglin c mutants potently and selectively inhibiting kexin or furin
FEBS Lett.
556
116-120
2004
Saccharomyces cerevisiae
Sarac, M.S.; Cameron, A.; Lindberg, I.
The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo
Infect. Immun.
70
7136-7139
2002
Mus musculus
Dahlen, J.R.; Jean, F.; Thomas, G.; Foster, D.C.; Kisiel, W.
Inhibition of soluble recombinant furin by human proteinase inhibitor 8
J. Biol. Chem.
273
1851-1854
1998
Homo sapiens
Krysan, D.J.; Rockwell, N.C.; Fuller, R.S.
Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides
J. Biol. Chem.
274
23229-23234
1999
Homo sapiens
Cameron, A.; Appel, J.; Houghten, R.A.; Lindberg, I.
Polyarginines are potent furin inhibitors
J. Biol. Chem.
275
36741-36749
2000
Homo sapiens, Mus musculus
Basak, A.; Koch, P.; Dupelle, M.; Fricker, L.D.; Devi, L.A.; Chretien, M.; Seidah, N.G.
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
J. Biol. Chem.
276
32720-32728
2001
Homo sapiens
Bowler, R.P.; Nicks, M.; Olsen, D.A.; Thogersen, I.B.; Valnickova, Z.; Hojrup, P.; Franzusoff, A.; Enghild, J.J.; Crapo, J.D.
Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase
J. Biol. Chem.
277
16505-16511
2002
Homo sapiens, Mus musculus, Rattus norvegicus
Henrich, S.; Cameron, A.; Bourenkov, G.P.; Kiefersauer, R.; Huber, R.; Lindberg, I.; Bode, W.; Than, M.E.
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity
Nat. Struct. Biol.
10
520-526
2003
Mus musculus
Sheng, S.; Carattino, M.D.; Bruns, J.B.; Hughey, R.P.; Kleyman, T.R.
Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition
Am. J. Physiol. Renal Physiol.
290
F1488-1496
2006
Xenopus laevis
Stawowy, P.; Kallisch, H.; Kilimnik, A.; Margeta, C.; Seidah, N.G.; Chretien, M.; Fleck, E.; Graf, K.
Proprotein convertases regulate insulin-like growth factor 1-induced membrane-type 1 matrix metalloproteinase in VSMCs via endoproteolytic activation of the insulin-like growth factor-1 receptor
Biochem. Biophys. Res. Commun.
321
531-538
2004
Rattus norvegicus
Peinado, J.R.; Kacprzak, M.M.; Leppla, S.H.; Lindberg, I.
Cross-inhibition between furin and lethal factor inhibitors
Biochem. Biophys. Res. Commun.
321
601-605
2004
Mus musculus
Mayer, G.; Boileau, G.; Bendayan, M.
The proprotein convertase furin colocalizes with caveolin-1 in the Golgi apparatus and endosomes of hepatocytes
Cell Tissue Res.
316
55-63
2004
Rattus norvegicus
Dey, A.; Norrbom, C.; Zhu, X.; Stein, J.; Zhang, C.; Ueda, K.; Steiner, D.F.
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
Endocrinology
145
1961-1971
2004
Mus musculus
Fujisawa, T.; Kamimura, H.; Hosaka, M.; Torii, S.; Izumi, T.; Kuwano, H.; Takeuchi, T.
Functional localization of proprotein-convertase furin and its substrate TGFb in EGF receptor-expressing gastric chief cells
Growth Factors
22
51-59
2004
Rattus norvegicus, Rattus norvegicus Wistar
Opal, S.M.; Artenstein, A.W.; Cristofaro, P.A.; Jhung, J.W.; Palardy, J.E.; Parejo, N.A.; Lim, Y.P.
Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication
Infect. Immun.
73
5101-5105
2005
Homo sapiens
Wang, P.; Tortorella, M.; England, K.; Malfait, A.M.; Thomas, G.; Arner, E.C.; Pei, D.
Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (aggrecanase-1) in the trans-Golgi network
J. Biol. Chem.
279
15434-15440
2004
Homo sapiens
Rozan, L.; Krysan, D.J.; Rockwell, N.C.; Fuller, R.S.
Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin
J. Biol. Chem.
279
35656-35663
2004
Mus musculus
Podsiadlo, P.; Komiyama, T.; Fuller, R.S.; Blum, O.
Furin inhibition by compounds of copper and zinc
J. Biol. Chem.
279
36219-36227
2004
Homo sapiens
Kacprzak, M.M.; Peinado, J.R.; Than, M.E.; Appel, J.; Henrich, S.; Lipkind, G.; Houghten, R.A.; Bode, W.; Lindberg, I.
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine
J. Biol. Chem.
279
36788-36794
2004
Homo sapiens
Koo, B.H.; Longpre, J.M.; Somerville, R.P.; Alexander, J.P.; Leduc, R.; Apte, S.S.
Cell-surface processing of pro-ADAMTS9 by furin
J. Biol. Chem.
281
12485-12494
2006
Homo sapiens
Geiselhart, V.; Bastone, P.; Kempf, T.; Schnolzer, M.; Lochelt, M.
Furin-mediated cleavage of the feline foamy virus Env leader protein
J. Virol.
78
13573-13581
2004
Bos taurus
Anders, L.; Mertins, P.; Lammich, S.; Murgia, M.; Hartmann, D.; Saftig, P.; Haass, C.; Ullrich, A.
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenins transcriptional activity
Mol. Cell. Biol.
26
3917-3934
2006
Homo sapiens, Mus musculus
Remacle, A.G.; Rozanov, D.V.; Fugere, M.; Day, R.; Strongin, A.Y.
Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP
Oncogene
25
5648-5655
2006
Homo sapiens
Dufour, E.K.; Desilets, A.; Longpre, J.M.; Leduc, R.
Stability of mutant serpin/furin complexes: dependence on pH and regulation at the deacylation step
Protein Sci.
14
303-315
2005
Homo sapiens
Han, J.; Gu, J.; Chi, C.
Possible role of histone H1 in the regulation of furin-dependent proprotein processing
Acta Biochim. Biophys. Sin.
39
173-180
2007
Homo sapiens
Guimont, P.; Grondin, F.; Dubois, C.M.
Sox9-dependent transcriptional regulation of the proprotein convertase furin
Am. J. Physiol. Cell Physiol.
293
C172-C183
2007
Homo sapiens, Mus musculus
Guo, X.L.; Li, L.; Wei, D.Q.; Zhu, Y.S.; Chou, K.C.
Cleavage mechanism of the H5N1 hemagglutinin by trypsin and furin
Amino Acids
35
375-382
2008
Mus musculus
Kim, J.M.; Jang, S.A.; Yu, B.J.; Sung, B.H.; Cho, J.H.; Kim, S.C.
High-level expression of an antimicrobial peptide histonin as a natural form by multimerization and furin-mediated cleavage
Appl. Microbiol. Biotechnol.
78
123-130
2008
Homo sapiens
Lee, S.N.; Kacprzak, M.M.; Day, R.; Lindberg, I.
Processing and trafficking of a prohormone convertase 2 active site mutant
Biochem. Biophys. Res. Commun.
355
825-829
2007
Homo sapiens
Kurmanova, A.; Llorente, A.; Polesskaya, A.; Garred, O.; Olsnes, S.; Kozlov, J.; Sandvig, K.
Structural requirements for furin-induced cleavage and activation of Shiga toxin
Biochem. Biophys. Res. Commun.
357
144-149
2007
Homo sapiens, Mus musculus
Bonod-Bidaud, C.; Beraud, M.; Vaganay, E.; Delacoux, F.; Font, B.; Hulmes, D.J.; Ruggiero, F.
Enzymatic cleavage specificity of the proalpha1(V) chain processing analysed by site-directed mutagenesis
Biochem. J.
405
299-306
2007
Homo sapiens
Decha, P.; Rungrotmongkol, T.; Intharathep, P.; Malaisree, M.; Aruksakunwong, O.; Laohpongspaisan, C.; Parasuk, V.; Sompornpisut, P.; Pianwanit, S.; Kokpol, S.; Hannongbua, S.
Source of high pathogenicity of an Avian influenza virus H5N1: Why H5 is better cleaved by furin
Biophys. J.
95
128-134
2008
Mus musculus
Bhattacharjya, S.; Xu, P.; Wang, P.; Osborne, M.J.; Ni, F.
Conformational analyses of a partially-folded bioactive prodomain of human furin
Biopolymers
86
329-344
2007
Homo sapiens
Pesu, M.; Muul, L.; Kanno, Y.; OShea, J.J.
Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma
Blood
108
983-985
2006
Homo sapiens, Mus musculus
Silvestri, L.; Pagani, A.; Camaschella, C.
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
Blood
111
924-931
2008
Mus musculus
Lapierre, M.; Siegfried, G.; Scamuffa, N.; Bontemps, Y.; Calvo, F.; Seidah, N.G.; Khatib, A.M.
Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells malignant phenotypes: role of tissue inhibitors of metalloproteinase-1
Cancer Res.
67
9030-9034
2007
Homo sapiens
Page, R.E.; Klein-Szanto, A.J.; Litwin, S.; Nicolas, E.; Al-Jumaily, R.; Alexander, P.; Godwin, A.K.; Ross, E.A.; Schilder, R.J.; Bassi, D.E.
Increased expression of the pro-protein convertase furin predicts decreased survival in ovarian cancer
Cell. Oncol.
29
289-299
2007
Homo sapiens
Walker, M.B.; Miller, C.T.; Coffin Talbot, J.; Stock, D.W.; Kimmel, C.B.
Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning
Dev. Biol.
295
194-205
2006
Danio rerio (Q1KHF8), Danio rerio (Q1KHF9), Danio rerio
Rabah, N.; Gauthier, D.; Dikeakos, J.D.; Reudelhuber, T.L.; Lazure, C.
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
FEBS J.
274
3482-3491
2007
Homo sapiens
Pasquato, A.; Dettin, M.; Basak, A.; Gambaretto, R.; Tonin, L.; Seidah, N.G.; Di Bello, C.
Heparin enhances the furin cleavage of HIV-1 gp160 peptides
FEBS Lett.
581
5807-5813
2007
Homo sapiens
Wanyiri, J.W.; OConnor, R.; Allison, G.; Kim, K.; Kane, A.; Qiu, J.; Plaut, A.G.; Ward, H.D.
Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity
Infect. Immun.
75
184-192
2007
Cryptosporidium parvum, Homo sapiens
Feliciangeli, S.F.; Thomas, L.; Scott, G.K.; Subbian, E.; Hung, C.H.; Molloy, S.S.; Jean, F.; Shinde, U.; Thomas, G.
Identification of a pH sensor in the furin propeptide that regulates enzyme activation
J. Biol. Chem.
281
16108-16116
2006
Homo sapiens
Benjannet, S.; Rhainds, D.; Hamelin, J.; Nassoury, N.; Seidah, N.G.
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications
J. Biol. Chem.
281
30561-30572
2006
Homo sapiens
Shiryaev, S.A.; Remacle, A.G.; Ratnikov, B.I.; Nelson, N.A.; Savinov, A.Y.; Wei, G.; Bottini, M.; Rega, M.F.; Parent, A.; Desjardins, R.; Fugere, M.; Day, R.; Sabet, M.; Pellecchia, M.; Liddington, R.C.; Smith, J.W.; Mustelin, T.; Guiney, D.G.; Lebl, M.; Strongin, A.Y.
Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens
J. Biol. Chem.
282
20847-20853
2007
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Veit, G.; Zimina, E.P.; Franzke, C.W.; Kutsch, S.; Siebolds, U.; Gordon, M.K.; Bruckner-Tuderman, L.; Koch, M.
Shedding of collagen XXIII is mediated by furin and depends on the plasma membrane microenvironment
J. Biol. Chem.
282
27424-27435
2007
Mus musculus
Bruns, J.B.; Carattino, M.D.; Sheng, S.; Maarouf, A.B.; Weisz, O.A.; Pilewski, J.M.; Hughey, R.P.; Kleyman, T.R.
Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit
J. Biol. Chem.
282
6153-6160
2007
Homo sapiens, Mus musculus
Harris, M.; Garcia-Caballero, A.; Stutts, M.J.; Firsov, D.; Rossier, B.C.
Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: Role of furin-mediated endogenous proteolysis
J. Biol. Chem.
283
7455-7463
2008
Xenopus sp.
Kusakabe, M.; Cheong, P.; Nikfar, R.; McLennan, I.S.; Koishi, K.
The structure of the TGF-beta latency associated peptide region determines the ability of the proprotein convertase furin to cleave TGF-beta s
J. Cell. Biochem.
103
311-320
2007
synthetic construct
Pasquato, A.; Seidah, N.G.
The H5N1 influenza variant Fujian-like hemagglutinin selected following vaccination exhibits a compromised furin cleavage: Neurological consequences of highly pathogenic Fujian H5N1 strains
J. Mol. Neurosci.
35
339-343
2008
Homo sapiens
Clemente, R.; de la Torre, J.C.
Cell-to-cell spread of Borna disease virus proceeds in the absence of the virus primary receptor and furin-mediated processing of the virus surface glycoprotein
J. Virol.
81
5968-5977
2007
Cricetulus griseus
Tellier, E.; Negre-Salvayre, A.; Bocquet, B.; Itohara, S.; Hannun, Y.A.; Salvayre, R.; Auge, N.
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway
Mol. Cell. Biol.
27
2997-3007
2007
Homo sapiens
Wang, L.; Xu, D.; Qian, M.; Yang, G.; Wu, X.
Identification and characterization of Trichoplusia ni furin truncated mutant
Protein Pept. Lett.
13
171-175
2006
Trichoplusia ni (Q5DNW1), Trichoplusia ni
Portela-Gomes, G.M.; Grimelius, L.; Stridsberg, M.
Prohormone convertases 1/3, 2, furin and protein 7B2 (Secretogranin V) in endocrine cells of the human pancreas
Regul. Pept.
146
117-124
2008
Homo sapiens
Follis, K.E.; York, J.; Nunberg, J.H.
Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell-cell fusion but does not affect virion entry
Virology
350
358-369
2006
Homo sapiens
Komiyama, T.; Coppola, J.M.; Larsen, M.J.; van Dort, M.E.; Ross, B.D.; Day, R.; Rehemtulla, A.; Fuller, R.S.
Inhibition of furin/PC-catalyzed surface and intracellular processing by small molecules
J. Biol. Chem.
284
15729-15738
2009
Homo sapiens
Antoine, M.; Koehl, R.; Tag, C.G.; Gressner, A.M.; Hellerbrand, C.; Kiefer, P.
Secreted cysteine-rich FGF receptor derives from posttranslational processing by furin-like prohormone convertases
Biochem. Biophys. Res. Commun.
382
359-364
2009
Gallus gallus
Blanchet, M.H.; Le Good, J.A.; Mesnard, D.; Oorschot, V.; Baflast, S.; Minchiotti, G.; Klumperman, J.; Constam, D.B.
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
EMBO J.
27
2580-2591
2008
Mus musculus
Hook, V.; Funkelstein, L.; Toneff, T.; Mosier, C.; Hwang, S.R.
Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin
Endocrine
35
429-437
2009
Homo sapiens
Worachartcheewan, A.; Nantasenamat, C.; Naenna, T.; Isarankura-Na-Ayudhya, C.; Prachayasittikul, V.
Modeling the activity of furin inhibitors using artificial neural network
Eur. J. Med. Chem.
44
1664-1673
2009
synthetic construct
Ozden, S.; Lucas-Hourani, M.; Ceccaldi, P.E.; Basak, A.; Valentine, M.; Benjannet, S.; Hamelin, J.; Jacob, Y.; Mamchaoui, K.; Mouly, V.; Despres, P.; Gessain, A.; Butler-Browne, G.; Chretien, M.; Tangy, F.; Vidalain, P.O.; Seidah, N.G.
Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein
J. Biol. Chem.
283
21899-21908
2008
synthetic construct
Ikonomov, O.C.; Fligger, J.; Sbrissa, D.; Dondapati, R.; Mlak, K.; Deeb, R.; Shisheva, A.
Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin
J. Biol. Chem.
284
3750-3761
2009
Homo sapiens
Han, J.; Wang, Y.; Wang, S.; Chi, C.
Interaction of Mint3 with Furin regulates the localization of Furin in the trans-Golgi network
J. Cell Sci.
121
2217-2223
2008
synthetic construct
Gagliardo, B.; Kubat, N.; Faye, A.; Jaouen, M.; Durel, B.; Deschemin, J.C.; Canonne-Hergaux, F.; Sari, M.A.; Vaulont, S.
Pro-hepcidin is unable to degrade the iron exporter ferroportin unless maturated by a furin-dependent process
J. Hepatol.
50
394-401
2009
Homo sapiens, Mus musculus
Ito, K.; Kim, K.H.; Lok, A.S.; Tong, S.
Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme
J. Virol.
83
3507-3517
2009
Gallus gallus, Homo sapiens
Coppola, J.M.; Bhojani, M.S.; Ross, B.D.; Rehemtulla, A.
A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness
Neoplasia
10
363-370
2008
Cricetulus griseus, Homo sapiens
Huynh, T.T.; Chan, K.S.; Piva, T.J.
Effect of ultraviolet radiation on the expression of pp38MAPK and furin in human keratinocyte-derived cell lines
Photodermatol. Photoimmunol. Photomed.
25
20-29
2009
Homo sapiens
Gawlik, K.; Shiryaev, S.A.; Zhu, W.; Motamedchaboki, K.; Desjardins, R.; Day, R.; Remacle, A.G.; Stec, B.; Strongin, A.Y.
Autocatalytic activation of the furin zymogen requires removal of the emerging enzymes N-terminus from the active site
PLoS ONE
4
e5031
2009
Homo sapiens
Gagnon, J.; Mayne, J.; Mbikay, M.; Woulfe, J.; Chretien, M.
Expression of PCSK1 (PC1/3), PCSK2 (PC2) and PCSK3 (furin) in mouse small intestine
Regul. Pept.
152
54-60
2009
Mus musculus
Izidoro, M.A.; Gouvea, I.E.; Santos, J.A.; Assis, D.M.; Oliveira, V.; Judice, W.A.; Juliano, M.A.; Lindberg, I.; Juliano, L.
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions
Arch. Biochem. Biophys.
487
105-114
2009
Homo sapiens
Nagamine, S.; Keino-Masu, K.; Shiomi, K.; Masu, M.
Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases
Biochem. Biophys. Res. Commun.
391
107-112
2010
Rattus norvegicus
Parker, M.W.; Hellman, L.M.; Xu, P.; Fried, M.G.; Vander Kooi, C.W.
Furin processing of semaphorin 3F determines its anti-angiogenic activity by regulating direct binding and competition for neuropilin
Biochemistry
49
4068-4075
2010
Homo sapiens
Dragulescu-Andrasi, A.; Liang, G.; Rao, J.
In vivo bioluminescence imaging of furin activity in breast cancer cells using bioluminogenic substrates
Bioconjug. Chem.
20
1660-1666
2009
Homo sapiens, Mus musculus
Kelty, B.P.; Curry, T.E.
Ovarian furin (proprotein convertase subtilisin/kexin type3): expression, localization, and potential role in ovulation in the rat
Biol. Reprod.
83
147-154
2010
Rattus norvegicus
Wang, F.; Ren, J.; Qiu, X.C.; Wang, L.F.; Zhu, Q.; Zhang, Y.Q.; Huan, Y.; Meng, Y.L.; Yao, L.B.; Chen, S.Y.; Xu, Y.M.; Yang, A.G.
Selective cytotoxicity to HER2-positive tumor cells by a recombinant e23sFv-TD-tBID protein containing a furin cleavage sequence
Clin. Cancer Res.
16
2284-2294
2010
Homo sapiens
Semenov, A.G.; Postnikov, A.B.; Tamm, N.N.; Seferian, K.R.; Karpova, N.S.; Bloshchitsyna, M.N.; Koshkina, E.V.; Krasnoselsky, M.I.; Serebryanaya, D.V.; Katrukha, A.G.
Processing of pro-brain natriuretic peptide is suppressed by O-glycosylation in the region close to the cleavage site
Clin. Chem.
55
489-498
2009
Homo sapiens
Zhou, J.; Cai, Z.H.
Molecular cloning and characterization of prohormone convertase 1 gene in abalone (Haliotis diversicolor supertexta)
Comp. Biochem. Physiol. B
155
331-339
2010
Haliotis diversicolor supertexta
Basak, A.; Chen, A.; Scamuffa, N.; Mohottalage, D.; Basak, S.; Khatib, A.M.
Blockade of furin activity and furin-induced tumor cells malignant phenotypes by the chemically synthesized human furin prodomain
Curr. Med. Chem.
17
2214-2221
2010
Homo sapiens
Cousin, C.; Bracquart, D.; Contrepas, A.; Corvol, P.; Muller, L.; Nguyen, G.
Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma
Hypertension
53
1077-1082
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Remacle, A.G.; Gawlik, K.; Golubkov, V.S.; Cadwell, G.W.; Liddington, R.C.; Cieplak, P.; Millis, S.Z.; Desjardins, R.; Routhier, S.; Yuan, X.W.; Neugebauer, W.A.; Day, R.; Strongin, A.Y.
Selective and potent furin inhibitors protect cells from anthrax without significant toxicity
Int. J. Biochem. Cell Biol.
42
987-995
2010
Homo sapiens
Tian, S.; Jianhua, W.
Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
Int. J. Biol. Sci.
6
89-95
2010
Mus musculus
Nelsen, S.M.; Christian, J.L.
Site-specific cleavage of BMP4 by furin, PC6, and PC7
J. Biol. Chem.
284
27157-27166
2009
Xenopus laevis
Becker, G.L.; Sielaff, F.; Than, M.E.; Lindberg, I.; Routhier, S.; Day, R.; Lu, Y.; Garten, W.; Steinmetzer, T.
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics
J. Med. Chem.
53
1067-1075
2010
Homo sapiens
Tong, Y.; Tong, S.; Zhao, X.; Wang, J.; Jun, J.; Park, J.; Wands, J.; Li, J.
Initiation of duck hepatitis B virus infection requires cleavage by a furin-like protease
J. Virol.
84
4569-4578
2010
Anas platyrhynchos
Delfino, K.R.; Southey, B.R.; Sweedler, J.V.; Rodriguez-Zas, S.L.
Genome-wide census and expression profiling of chicken neuropeptide and prohormone convertase genes
Neuropeptides
44
31-44
2010
Gallus gallus (Q91000), Gallus gallus
Hagiwara, S.; Murakumo, Y.; Mii, S.; Shigetomi, T.; Yamamoto, N.; Furue, H.; Ueda, M.; Takahashi, M.
Processing of CD109 by furin and its role in the regulation of TGF-beta signaling
Oncogene
29
2181-2191
2010
Homo sapiens
Zhou, Z.; Shen, T.; Zhang, B.H.; Lv, X.Y.; Lin, H.Y.; Zhu, C.; Xue, L.Q.; Wang, H.
The proprotein convertase furin in human trophoblast: Possible role in promoting trophoblast cell migration and invasion
Placenta
30
929-938
2009
Homo sapiens
Carney, T.J.; Feitosa, N.M.; Sonntag, C.; Slanchev, K.; Kluger, J.; Kiyozumi, D.; Gebauer, J.M.; Coffin Talbot, J.; Kimmel, C.B.; Sekiguchi, K.; Wagener, R.; Schwarz, H.; Ingham, P.W.; Hammerschmidt, M.
Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes
PLoS Genet.
6
e1000907
2010
Danio rerio
Basak, A.; Khatib, A.M.; Mohottalage, D.; Basak, S.; Kolajova, M.; Bag, S.S.; Basak, A.
A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C
PLoS ONE
4
e7700
2009
Homo sapiens
Pavlaki, M.; Zucker, S.; Dufour, A.; Calabrese, N.; Bahou, W.; Cao, J.
Furin functions as a nonproteolytic chaperone for matrix metalloproteinase-28: MMP-28 propeptide sequence requirement
Biochem. Res. Int.
2011
630319
2011
Mus musculus
Izidoro, M.A.; Assis, D.M.; Oliveira, V.; Santos, J.A.; Juliano, M.A.; Lindberg, I.; Juliano, L.
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein
Biol. Chem.
391
1105-1112
2010
Homo sapiens
Kuester, M.; Becker, G.L.; Hardes, K.; Lindberg, I.; Steinmetzer, T.; Than, M.E.
Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors
Biol. Chem.
392
973-981
2011
Mus musculus
Sielaff, F.; Than, M.E.; Bevec, D.; Lindberg, I.; Steinmetzer, T.
New furin inhibitors based on weakly basic amidinohydrazones
Bioorg. Med. Chem. Lett.
21
836-840
2011
Homo sapiens
Susan-Resiga, D.; Essalmani, R.; Hamelin, J.; Asselin, M.C.; Benjannet, S.; Chamberland, A.; Day, R.; Szumska, D.; Constam, D.; Bhattacharya, S.; Prat, A.; Seidah, N.G.
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10
J. Biol. Chem.
286
22785-22794
2011
Homo sapiens
Essalmani, R.; Susan-Resiga, D.; Chamberland, A.; Abifadel, M.; Creemers, J.W.; Boileau, C.; Seidah, N.G.; Prat, A.
In vivo evidence that furin from hepatocytes inactivates PCSK9
J. Biol. Chem.
286
4257-4263
2011
Mus musculus
Arsenault, D.; Lucien, F.; Dubois, C.M.
Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-golgi network to the cell surface
J. Cell. Physiol.
227
789-800
2012
Homo sapiens
Bourne, G.L.; Grainger, D.J.
Development and characterisation of an assay for furin activity
J. Immunol. Methods
364
101-108
2011
Homo sapiens
Cano-Monreal, G.; Williams, J.; Heidner, H.
An arthropod enzyme, Dfurin1, and a vertebrate furin homolog display distinct cleavage site sequence preferences for a shared viral proprotein substrate
J. Insect Sci.
10
29
2010
Drosophila melanogaster (P26016), Drosophila melanogaster
Hajdin, K.; DAlessandro, V.; Niggli, F.K.; Schaefer, B.W.; Bernasconi, M.
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model
PLoS ONE
5
e10445
2010
Homo sapiens, Mus musculus
Presser, L.D.; Haskett, A.; Waris, G.
Hepatitis C virus-induced furin and thrombospondin-1 activate TGF-beta1: role of TGF-beta1 in HCV replication
Virology
412
284-296
2011
Homo sapiens
Dahms, S.O.; Hardes, K.; Becker, G.L.; Steinmetzer, T.; Brandstetter, H.; Than, M.E.
X-ray structures of human furin in complex with competitive inhibitors
ACS Chem. Biol.
9
1113-1118
2014
Homo sapiens (P09958), Homo sapiens
Zhou, Z.; Zhang, Q.; Lu, X.; Wang, R.; Wang, H.; Wang, Y.L.; Zhu, C.; Lin, H.Y.; Wang, H.
The proprotein convertase furin is required for trophoblast syncytialization
Cell Death Dis.
4
e593-e602
2013
Mus musculus, Homo sapiens (P09958), Homo sapiens
Tafesse, F.G.; Guimaraes, C.P.; Maruyama, T.; Carette, J.E.; Lory, S.; Brummelkamp, T.R.; Ploegh, H.L.
GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin
J. Biol. Chem.
289
24005-24018
2014
Homo sapiens (P09958), Homo sapiens
Chen, Y.; Zhang, J.; Deng, M.
Furin mediates brain-derived neurotrophic factor upregulation in cultured rat astrocytes exposed to oxygen-glucose deprivation
J. Neurosci. Res.
93
189-194
2015
Rattus norvegicus, Rattus norvegicus Sprague Dawley
Tse, L.V.; Hamilton, A.M.; Friling, T.; Whittaker, G.R.
A novel activation mechanism of avian influenza virus H9N2 by furin
J. Virol.
88
1673-1683
2014
Gallus gallus, Homo sapiens (P09958), Homo sapiens
Fu, J.; Zhang, J.; Gong, Y.; Testa, C.L.; Klein-Szanto, A.J.
Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells
Mol. Carcinog.
54
698-706
2015
Homo sapiens (P09958), Homo sapiens
Salzberg, Y.; Ramirez-Suarez, N.J.; Buelow, H.E.
The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans
PLoS Genet.
10
e1004657
2014
Caenorhabditis elegans (O17798), Caenorhabditis elegans
El Najjar, F.; Lampe, L.; Baker, M.L.; Wang, L.F.; Dutch, R.E.
Analysis of cathepsin and furin proteolytic enzymes involved in viral fusion protein activation in cells of the bat reservoir host
PLoS ONE
10
e0115736
2015
Pteropus alecto
Yang, X.; Wang, Q.; Gao, Z.; Zhou, Z.; Peng, S.; Chang, W.L.; Lin, H.Y.; Zhang, W.; Wang, H.
Proprotein convertase furin regulates apoptosis and proliferation of granulosa cells in the rat ovary
PLoS ONE
8
e50479
2013
Rattus norvegicus
Harihar, S.; Pounds, K.M.; Iwakuma, T.; Seidah, N.G.; Welch, D.R.
Furin is the major proprotein convertase required for KISS1-to-Kisspeptin processing
PLoS ONE
9
e84958
2014
Homo sapiens (P09958)
Sjoeberg, M.; Wu, S.R.; Loeving, R.; Rantalainen, K.; Lindqvist, B.; Garoff, H.
Furin cleavage of the Moloney murine leukemia virus Env precursor reorganizes the spike structure
Proc. Natl. Acad. Sci. USA
111
6034-6039
2014
Homo sapiens (P09958)
Hada, K.; Isshiki, K.; Matsuda, S.; Yuasa, K.; Tsuji, A.
Engineering of alpha1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis
Protein Eng. Des. Sel.
26
123-131
2013
Homo sapiens (P09958)
Tay, F.P.; Huang, M.; Wang, L.; Yamada, Y.; Liu, D.X.
Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection
Virology
433
421-430
2012
Homo sapiens (P09958), Homo sapiens
Dahms, S.O.; Jiao, G.S.; Than, M.E.
Structural studies revealed active site distortions of human furin by a small molecule inhibitor
ACS Chem. Biol.
12
1211-1216
2017
Homo sapiens (P09958), Homo sapiens
Pearce, K.; Overton, L.; Gampe, R.; Barrett, G.; Taylor, J.; McKee, D.; Campobasso, N.; Nolte, R.; Reid, R.
BacMam production and crystal structure of nonglycosylated apo human furin at 1.89 A resolution
Acta Crystallogr. Sect. F
75
239-245
2019
Homo sapiens (P09958), Homo sapiens
Dahms, S.O.; Hardes, K.; Steinmetzer, T.; Than, M.E.
X-ray structures of the proprotein convertase furin bound with substrate analogue inhibitors reveal substrate specificity determinants beyond the S4 pocket
Biochemistry
57
925-934
2018
Homo sapiens (P09958)
Valiulyte, I.; Preitakaite, V.; Tamasauskas, A.; Kazlauskas, A.
Importance of the putative furin recognition site 742 RNRR 745 for antiangiogenic Sema3C activity in vitro
Braz. J. Med. Biol. Res.
51
e7786
2018
Homo sapiens (P09958), Homo sapiens
Ginefra, P.; Filippi, B.G.H.; Donovan, P.; Bessonnard, S.; Constam, D.B.
Compartment-specific biosensors reveal a complementary subcellular distribution of bioactive furin and PC7
Cell Rep.
22
2176-2189
2018
Homo sapiens (P09958)
Hardes, K.; Ivanova, T.; Thaa, B.; McInerney, G.M.; Klokk, T.I.; Sandvig, K.; Kuenzel, S.; Lindberg, I.; Steinmetzer, T.
Elongated and shortened peptidomimetic inhibitors of the proprotein convertase furin
ChemMedChem
12
613-620
2017
Homo sapiens (P09958)
Van Lam van, T.; Ivanova, T.; Hardes, K.; Heindl, M.R.; Morty, R.E.; Boettcher-Friebertshaeuser, E.; Lindberg, I.; Than, M.E.; Dahms, S.O.; Steinmetzer, T.
Design, synthesis, and characterization of macrocyclic inhibitors of the proprotein convertase furin
ChemMedChem
14
673-685
2019
Homo sapiens (P09958)
Bessonnard, S.; Mesnard, D.; Constam, D.
PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation
J. Cell Biol.
210
1185-1197
2015
Mus musculus (P23188)
Ortutay, Z.; Oksanen, A.; Aittomaeki, S.; Ortutay, C.; Pesu, M.
Proprotein convertase furin regulates T cell receptor-induced transactivation
J. Leukoc. Biol.
98
73-83
2015
Homo sapiens (P09958), Homo sapiens, Mus musculus (P23188), Mus musculus
Wilbers, R.H.; Westerhof, L.B.; van Raaij, D.R.; van Adrichem, M.; Prakasa, A.D.; Lozano-Torres, J.L.; Bakker, J.; Smant, G.; Schots, A.
Co-expression of the protease furin in Nicotiana benthamiana leads to efficient processing of latent transforming growth factor-beta1 into a biologically active protein
Plant Biotechnol. J.
14
1695-1704
2016
Homo sapiens (P09958), Homo sapiens
Mamedov, T.; Musayeva, I.; Acsora, R.; Gun, N.; Gulec, B.; Mammadova, G.; Cicek, K.; Hasanova, G.
Engineering, and production of functionally active human furin in N. benthamiana plant in vivo post-translational processing of target proteins by furin in plants
PLoS ONE
14
e0213438
2019
Homo sapiens (P09958), Homo sapiens
html completed
