Reference on EC 3.4.21.69 - Protein C (activated)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Esmon, C.T.
The roles of protein C and thrombomodulin in the regulation of blood coagulation
J. Biol. Chem.
264
4743-4746
1989
Bos taurus, Homo sapiens
Esmon, C.T.
The regulation of natural anticoagulant pathways
Science
235
1348-1352
1987
Homo sapiens
Stenflo, J.
A new vitamin K-dependent protein. Purification from bovine plasma and preliminary characterization
J. Biol. Chem.
251
355-363
1976
Bos taurus
Esmon, C.T.; Stenflo, J.; Suttie, J.W.; Jackson, C.M.
A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase
J. Biol. Chem.
251
3052-3056
1976
Bos taurus
Stone, S.R.; Hofsteenge, J.
Specificity of activated human protein C
Biochem. J.
230
497-502
1985
Homo sapiens
Nicolaes, G.A.F.; Tans, G.; Thomassen, C.L.G.D.; Hemker, H.C.; Pabinger, I.; Varadi, K.; Schwarz, H.P.; Rosing, J.
Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C
J. Biol. Chem.
270
21158-21166
1995
Homo sapiens
Rezaie, A.R.; Cooper, S.T.; Church, F.C.; Esmon, C.T.
Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex
J. Biol. Chem.
270
25336-25339
1995
Homo sapiens
Regan, L.M.; O'Brien, L.M.; Beattie, T.L.; Sudhakar, K.; Walker, F.J.; Fay, P.J.
Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase
J. Biol. Chem.
271
3982-3987
1996
Homo sapiens
Hill, K.A.W.; Castellino, F.J.
The binding of Mn2+ to bovine plasma protein C, des(1-41)-light chain protein C, and activated des(1-41)-light chain activated protein C
Arch. Biochem. Biophys.
254
196-202
1987
Bos taurus
Fernlund, P.; Stenflo, J.
Amino acid sequence of the light chain of bovine protein C
J. Biol. Chem.
257
12170-12179
1982
Bos taurus
Stenflo, J.; Fernlund, P.
Amino acid sequence of the heavy chain of bovine protein C
J. Biol. Chem.
257
12180-12190
1982
Bos taurus
Fay, W.P.; Owen, W.G.
Platelet plasminogen activator inhibitor: purification and characterization of interaction with plasminogen activators and activated protein C
Biochemistry
28
5773-5778
1989
Homo sapiens
Heeb, M.J.; Griffin, J.H.
Physiologic inhibition of human activated protein C by alpha 1-antitrypsin
J. Biol. Chem.
263
11613-11616
1988
Homo sapiens
Suzuki, K.; Matsuda, Y.; Kusumoto, H.; Nishioka, J.; Terada, M.; Yamashita, T.; Hashimoto, S.
Monoclonal antibodies to human protein C: effects on the biological activity of activated protein C and the thrombin-catalyzed activation of protein C1
J. Biochem.
97
127-138
1985
Homo sapiens
Steiner, S.A.; Castellino.F.J.
Kinetic mechanism for stimulation by monovalent cations of the amidase activity of the plasma protease bovine activated protein C
Biochemistry
24
609-617
1985
Bos taurus
Suzuki, K.; Nishioka, J.; Kusumoto, H.; Hashimoto, S.
Mechanism of inhibition of activated protein C by protein C inhibitor
J. Biochem.
95
187-195
1984
Homo sapiens
Suzuki, K.; Nishioka, J.; Hashimoto, S.
Protein C inhibitor. Purification from human plasma and characterization
J. Biol. Chem.
258
163-168
1983
Homo sapiens
Kisiel, W.; Canfield, W.M.; Ericsson, L.H.; Davie, E.W.
Anticoagulant properties of bovine plasma protein C following activation by thrombin
Biochemistry
16
5824-5831
1977
Bos taurus
Chi, C.W.; Liu, H.Z.; Liu, C.Y.; Chibber, B.A.K.; Castellino, F.J.
The inhibition of the enzymic activity of blood coagulation and fibrinolytic serine proteases by a new leupeptin-like inhibitor, and its structural analogs, isolated from Streptomyces griseus
J. Antibiot.
17
1506-1512
1989
Bos taurus
-
Walker, F.J.; Scandella, D.; Fay, P.J.
Identification of the binding site for activated protein C on the light chain of factors V and VIII
J. Biol. Chem.
265
1484-1489
1990
Bos taurus
Suzuki, K.; Kusumoto, H.; Nishioka, J.; Komiyama, Y.
Bovine plasma protein C inhibitor with structural and functional homologous properties to human plasma protein C inhibitor
J. Biochem.
107
381-388
1990
Bos taurus, Homo sapiens
Rezaie, A.R.; Esmon, C.T.
Conversion of glutamic acid 192 to glutamine in activated protein C changes the substrate specificity and increases reactivity toward macromolecular inhibitors
J. Biol. Chem.
268
19943-19948
1993
Homo sapiens
Hermans, J.M.; Stone, S.R.
Interaction of activated protein C with serpins
Biochem. J.
295
239-245
1993
Homo sapiens
Christiansen, W.T.; Geng, J.P.; Castellino, F.J.
Structure-function assessment of the role of the helical stack domain in the properties of human recombinant protein C and activated protein C
Biochemistry
34
8082-8090
1995
Homo sapiens
Gruber, A.; Griffin, J.H.
Direct detection of activated protein C in blood from human subjects
Blood
79
2340-2348
1992
Homo sapiens
Taby, O.; Chabbat, J.; Steinbuch, M.
Inhibition of activated protein C by aprotinin and the use of the insolubilized inhibitor for its purification
Thromb. Res.
59
27-35
1990
Homo sapiens
Pratt, C.W.; Macik, B.G.; Church, F.C.
Protein C inhibitor: purification and proteinase reactivity
Thromb. Res.
53
595-602
1989
Homo sapiens
Yang, L.; Manithody, C.; Rezaie, A.R.
Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C
Biochemistry
41
6149-6157
2002
Homo sapiens (P04070)
Smirnov, M.D.; Safa, O.; Esmon, N.L.; Esmon, C.T.
Inhibition of activated protein C anticoagulant activity by prothrombin
Blood
94
3839-3846
1999
Homo sapiens
Colucci, M.; Stramaglia, A.M.; Mascolo, E.; Napoleone, E.; Lorenzet, R.; Semeraro, N.
Monocytes, but not endothelial cells, downregulate the anticoagulant activity of activated protein C
Br. J. Haematol.
112
519-526
2001
Homo sapiens
Mann, K.G.; Hockin, M.F.; Begin, K.J.; Kalafatis, M.
Activated protein C cleavage of factor Va leads to dissociation of the A2 domain
J. Biol. Chem.
272
20678-20683
1997
Bos taurus
He, X.; Rezaie, A.R.
Identification and characterization of the sodium-binding site of activated protein C
J. Biol. Chem.
274
4970-4976
1999
Homo sapiens
Yegneswaran, S.; Smirnov, M.D.; Safa, O.; Esmon, N.L.; Esmon, C.T.; Johnson, A.E.
Relocating the active site of activated protein C eliminates the need for its protein S cofactor. A fluorescence resonance energy transfer study
J. Biol. Chem.
274
5462-5468
1999
Homo sapiens
Friedrich, U.; Blom, A.M.; Dahlbaeck, B.; Villoutreix, B.O.
Structural and energetic characteristics of the heparin-binding site in antithrombotic protein C
J. Biol. Chem.
276
24122-24128
2001
Homo sapiens
Schmidt, A.E.; Padmanabhan, K.; Underwood, M.C.; Bode, W.; Mather, T.; Bajaj, S.P.
Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops
J. Biol. Chem.
277
28987-28995
2002
Homo sapiens
Yegneswaran, S.; Deguchi, H.; Griffin, J.H.
Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles
J. Biol. Chem.
278
14614-14621
2003
Bos taurus, Homo sapiens
Fernandez, J.A.; Petaja, J.; Griffin, J.H.
Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C
Thromb. Haemost.
82
1462-1468
1999
Homo sapiens
Cvirn, G.; Gallistl, S.; Koestenberger, M.; Kutschera, J.; Leschnik, B.; Muntean, W.
Alpha 2-macroglobulin enhances prothrombin activation and thrombin potential by inhibiting the anticoagulant protein C/protein S system in cord and adult plasma
Thromb. Res.
105
433-439
2002
Homo sapiens
Varfaj, F.; Neuberg, J.; Jenkins, P.V.; Wakabayashi, H.; Fay, P.J.
Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa
Biochem. J.
396
355-362
2006
Homo sapiens
Nicolaes, G.A.F.; Sorensen, K.W.; Friedrich, U.; Tans, G.; Rosing, J.; Autin, L.; Dahlbaeck, B.; Villoutreix, B.O.
Altered inactivation pathway of factor Va by activated protein C in the presence of heparin
Eur. J. Biochem.
271
2724-2736
2004
Homo sapiens
Sun, Y.H.; Tran, S.; Norstrom, E.A.; Dahlbaeck, B.
Enhanced rate of cleavage at Arg-306 and Arg-506 in coagulation factor Va by Gla domain-mutated human-activated protein C
J. Biol. Chem.
279
47528-47535
2004
Homo sapiens
Pecheniuk, N.M.; Deguchi, H.; Griffin, J.H.
Cholesterol enhances phospholipid-dependent activated protein C anticoagulant activity
J. Thromb. Haemost.
3
340-345
2005
Homo sapiens
Gale, A.J.; Griffin, J.H.
Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va
Proteins
54
433-441
2004
Homo sapiens
Brueckmann, M.; Horn, S.; Lang, S.; Fukudome, K.; Schulze Nahrup, A.; Hoffmann, U.; Kaden, J.J.; Borggrefe, M.; Haase, K.K.; Huhle, G.
Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1
Thromb. Haemost.
93
743-750
2005
Homo sapiens
Yang, L.; Manithody, C.; Rezaie, A.R.
The functional significance of the autolysis loop in protein C and activated protein C
Thromb. Haemost.
94
60-68
2005
Homo sapiens
Ji, S.L.; Du, H.Y.; Chi, Y.Q.; Cui, H.F.; Cao, J.C.; Geng, M.Y.; Guan, H.S.
Effects of dermatan sulfate derivatives on platelet surface P-selectin expression and protein C activity in blood of inflammatory bowel disease patients
World J. Gastroenterol.
10
3485-3489
2004
Homo sapiens
Sharma, G.R.; Gerlitz, B.; Berg, D.T.; Cramer, M.S.; Jakubowski, J.A.; Galbreath, E.J.; Heuer, J.G.; Grinnell, B.W.
Activated protein C modulates chemokine response and tissue injury in experimental sepsis
Adv. Exp. Med. Biol.
614
83-91
2008
Rattus norvegicus
O'Brien, L.A.; Richardson, M.A.; Mehrbod, S.F.; Berg, D.T.; Gerlitz, B.; Gupta, A.; Grinnell, B.W.
Activated protein C decreases tumor necrosis factor-related apoptosis-inducing ligand by an EPCR-independent mechanism involving Egr-1/Erk-1/2 activation
Arterioscler. Thromb. Vasc. Biol.
27
2634-2641
2007
Homo sapiens
Qureshi, S.H.; Manithody, C.; Bae, J.S.; Yang, L.; Rezaie, A.R.
Autolysis loop restricts the specificity of activated protein C: analysis by FRET and functional assays
Biophys. Chem.
134
239-245
2008
Homo sapiens
Maurissen, L.F.; Thomassen, M.C.; Nicolaes, G.A.; Dahlbaeck, B.; Tans, G.; Rosing, J.; Hackeng, T.M.
Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation
Blood
111
3034-3041
2008
Homo sapiens
Khrenov, A.V.; Ananyeva, N.M.; Saenko, E.L.
Role of the B domain in proteolytic inactivation of activated coagulation factor VIII by activated protein C and activated factor X
Blood Coagul. Fibrinolysis
17
379-388
2006
Homo sapiens
Brueckmann, M.; Nahrup, A.S.; Lang, S.; Bertsch, T.; Fukudome, K.; Liebe, V.; Kaden, J.J.; Hoffmann, U.; Borggrefe, M.; Huhle, G.
Recombinant human activated protein C upregulates the release of soluble fractalkine from human endothelial cells
Br. J. Haematol.
133
550-557
2006
Homo sapiens
Yesilirmak, D.C.; Kumral, A.; Baskin, H.; Ergur, B.U.; Aykan, S.; Genc, S.; Genc, K.; Yilmaz, O.; Tugyan, K.; Giray, O.; Duman, N.; Ozkan, H.
Activated protein C reduces endotoxin-induced white matter injury in the developing rat brain
Brain Res.
1164
14-23
2007
Rattus norvegicus
Baillie, J.K.
Activated protein C: controversy and hope in the treatment of sepsis
Curr. Opin. Investig. Drugs
8
933-938
2007
Homo sapiens
Sakar, A.; Vatansever, S.; Sepit, L.; Ozbilgin, K.; Yorgancioglu, A.
Effect of recombinant human activated protein C on apoptosis-related proteins
Eur. J. Histochem.
51
103-109
2007
Homo sapiens
Beaulieu, L.M.; Church, F.C.
Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1
Exp. Cell Res.
313
677-687
2007
Homo sapiens
Hughes, M.
Recombinant human activated protein C
Int. J. Antimicrob. Agents
28
90-94
2006
Homo sapiens
Jackson, C.J.; Xue, M.
Activated protein C - an anticoagulant that does more than stop clots
Int. J. Biochem. Cell Biol.
40
2692-2697
2008
Homo sapiens
Baltch, A.L.; Bopp, L.H.; Ritz, W.J.; Michelsen, P.B.; Yan, S.B.; Um, S.; Smith, R.P.
Effect of recombinant human activated protein C on the bactericidal activity of human monocytes and modulation of pro-inflammatory cytokines in the presence of antimicrobial agents
J. Antimicrob. Chemother.
59
1177-1181
2007
Homo sapiens
Feistritzer, C.; Schuepbach, R.A.; Mosnier, L.O.; Bush, L.A.; Di Cera, E.; Griffin, J.H.; Riewald, M.
Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells
J. Biol. Chem.
281
20077-20084
2006
Homo sapiens
Preston, R.J.; Ajzner, E.; Razzari, C.; Karageorgi, S.; Dua, S.; Dahlbaeck, B.; Lane, D.A.
Multifunctional specificity of the protein C/activated protein C Gla domain
J. Biol. Chem.
281
28850-28857
2006
Homo sapiens
Norstrom, E.A.; Tran, S.; Steen, M.; Dahlbaeck, B.
Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va
J. Biol. Chem.
281
31486-31494
2006
Homo sapiens
Varfaj, F.; Wakabayashi, H.; Fay, P.J.
Residues surrounding Arg336 and Arg562 contribute to the disparate rates of proteolysis of factor VIIIa catalyzed by activated protein C
J. Biol. Chem.
282
20264-20272
2007
Homo sapiens
Yang, L.; Bae, J.S.; Manithody, C.; Rezaie, A.R.
Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1
J. Biol. Chem.
282
25493-25500
2007
Homo sapiens
Yegneswaran, S.; Kojima, Y.; Nguyen, P.M.; Gale, A.J.; Heeb, M.J.; Griffin, J.H.
Factor Va residues 311-325 represent an activated protein C binding region
J. Biol. Chem.
282
28353-28361
2007
Homo sapiens
Mosnier, L.O.; Yang, X.V.; Griffin, J.H.
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions
J. Biol. Chem.
282
33022-33033
2007
Homo sapiens
Bae, J.S.; Yang, L.; Manithody, C.; Rezaie, A.R.
Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties
J. Biol. Chem.
282
9251-9259
2007
Homo sapiens
Tran, S.; Norstrom, E.; Dahlbaeck, B.
Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va
J. Biol. Chem.
283
6648-6655
2008
Homo sapiens
Stephenson, D.A.; Toltl, L.J.; Beaudin, S.; Liaw, P.C.
Modulation of monocyte function by activated protein C, a natural anticoagulant
J. Immunol.
177
2115-2122
2006
Homo sapiens
Hensley, L.E.; Stevens, E.L.; Yan, S.B.; Geisbert, J.B.; Macias, W.L.; Larsen, T.; Daddario-DiCaprio, K.M.; Cassell, G.H.; Jahrling, P.B.; Geisbert, T.W.
Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever
J. Infect. Dis.
196 Suppl 2
S390-S399
2007
Homo sapiens
De Nanteuil, G.; Gloanec, P.; Beguin, S.; Giesen, P.L.; Hemker, H.C.; Mennecier, P.; Rupin, A.; Verbeuren, T.J.
Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders
J. Med. Chem.
49
5047-5050
2006
Homo sapiens
Griffin, J.H.; Fernandez, J.A.; Gale, A.J.; Mosnier, L.O.
Activated protein C
J. Thromb. Haemost.
5 Suppl 1
73-80
2007
Homo sapiens, Mus musculus
Cheng, T.; Petraglia, A.L.; Li, Z.; Thiyagarajan, M.; Zhong, Z.; Wu, Z.; Liu, D.; Maggirwar, S.B.; Deane, R.; Fernandez, J.A.; LaRue, B.; Griffin, J.H.; Chopp, M.; Zlokovic, B.V.
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage
Nat. Med.
12
1278-1285
2006
Homo sapiens
Nold, M.F.; Nold-Petry, C.A.; Fischer, D.; Richter, B.; Blaheta, R.; Pfeilschifter, J.; Muhl, H.; Schranz, D.; Veldman, A.
Activated protein C downregulates p38 mitogen-activated protein kinase and improves clinical parameters in an in-vivo model of septic shock
Thromb. Haemost.
98
1118-1126
2007
Homo sapiens, Sus scrofa
Gennari, L.C.; Blanco, A.N.; Dominguez, M.P.; Grosso, S.H.; Lazzari, M.A.
Endogenous or exogenous coagulation factor level and the response to activated protein C
Thromb. Res.
118
269-273
2006
Homo sapiens
Cimenti, C.; Koestenberger, M.; Leschnik, B.; Haidl, H.; Muntean, W.
The respective and combined anticoagulant effects of recombinant human activated protein C, melagatran and heparins using CAT
Thromb. Res.
119
361-367
2007
Homo sapiens
Malm, K.; Arnljots, B.; Persson, I.M.; Dahlbaeck, B.
Antithrombotic and anticoagulant effects of wild type and Gla-domain mutated human activated protein C in rats
Thromb. Res.
120
531-539
2007
Homo sapiens
Slofstra, S.H.; ten Cate, H.; Spek, C.A.
Signal transduction induced by activated protein C: no role in protection against sepsis?
Trends Mol. Med.
12
374-381
2006
Homo sapiens
Bezuhly, M.; Cullen, R.; Esmon, C.T.; Morris, S.F.; West, K.A.; Johnston, B.; Liwski, R.S.
Role of activated protein C and its receptor in inhibition of tumor metastasis
Blood
113
3371-3374
2009
Homo sapiens
Elphick, G.F.; Sarangi, P.P.; Hyun, Y.M.; Hollenbaugh, J.A.; Ayala, A.; Biffl, W.L.; Chung, H.L.; Rezaie, A.R.; McGrath, J.L.; Topham, D.J.; Reichner, J.S.; Kim, M.
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration
Blood
113
4078-4085
2009
Homo sapiens
Galley, H.F.; El Sakka, N.E.; Webster, N.R.; Lowes, D.A.; Cuthbertson, B.H.
Activated protein C inhibits chemotaxis and interleukin-6 release by human neutrophils without affecting other neutrophil functions
Br. J. Anaesth.
100
815-819
2008
Homo sapiens
Takeyama, M.; Nogami, K.; Saenko, E.L.; Soeda, T.; Nishiya, K.; Ogiwara, K.; Yoshioka, A.; Shima, M.
Protein S down-regulates factor Xase activity independent of activated protein C: specific binding of factor VIII(a) to protein S inhibits interactions with factor IXa
Br. J. Haematol.
143
409-420
2008
Homo sapiens
Toltl, L.J.; Beaudin, S.; Liaw, P.C.; Liaw, P.C.
Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes
J. Immunol.
181
2165-2173
2008
Homo sapiens
Bakoush, O.; Ohlin, A.K.; Strandberg, K.; Kurkus, J.
Low plasma activated protein C-protein C inhibitor complex concentration is associated with vascular access failure in hemodialysis patients
Nephron. Clin. Pract.
110
c151-c157
2008
Homo sapiens
Koelbel, T.; Strandberg, K.; Donath, T.; Mattiasson, I.; Stenflo, J.; Lindblad, B.
Activated protein C-protein C inhibitor complex in patients with abdominal aortic aneurysms: is it associated with diameter and growth rate?
Vasc. Endovascular. Surg.
42
135-140
2008
Homo sapiens
Guitton, C.; Cottereau, A.; Gerard, N.; Quillard, T.; Chauveau, A.; Devalliere, J.; Tonnerre, P.; Charreau, B.
Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-kappaB, and ERK1/2 MAP kinases
Am. J. Physiol. Cell Physiol.
300
C833-C842
2011
Homo sapiens
Barhoover, M.A.; Kalafatis, M.
Cleavage at both Arg306 and Arg506 is required and sufficient for timely and efficient inactivation of factor Va by activated protein C
Blood Coagul. Fibrinolysis
22
317-324
2011
Homo sapiens
Schuepbach, R.A.; Velez, K.; Riewald, M.
Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain
Blood
117
6338-6346
2011
Homo sapiens
Bae, J.S.; Rezaie, A.R.
Activated protein C inhibits high mobility group box 1 signaling in endothelial cells
Blood
118
3952-3959
2011
Homo sapiens
Gramling, M.; Beaulieu, L.; Church, F.
Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction
Exp. Cell Res.
316
314-328
2010
Homo sapiens
Seol, J.W.; Lee, Y.J.; Jackson, C.J.; Sambrook, P.N.; Park, S.Y.
Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-kappaB pathways
Int. J. Mol. Med.
27
835-840
2011
Homo sapiens
Du, Z.J.; Yamamoto, T.; Ueda, T.; Suzuki, M.; Tano, Y.; Kamei, M.
Activated protein C rescues the retina from ischemia-induced cell death
Invest. Ophthalmol. Vis. Sci.
52
987-993
2011
Homo sapiens
Sen, P.; Sahoo, S.; Pendurthi, U.R.; Rao, L.V.
Zinc modulates the interaction of protein C and activated protein C with endothelial cell protein C receptor
J. Biol. Chem.
285
20410-20420
2010
Homo sapiens
Nicolaes, G.A.; Bock, P.E.; Segers, K.; Wildhagen, K.C.; Dahlbaeck, B.; Rosing, J.
Inhibition of thrombin formation by active site mutated (S360A) activated protein C
J. Biol. Chem.
285
22890-22900
2010
Homo sapiens
Xue, M.; Chow, S.O.; Dervish, S.; Chan, Y.K.; Julovi, S.M.; Jackson, C.J.
Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and Tie2
J. Biol. Chem.
286
6742-6750
2011
Homo sapiens
Lichtnekert, J.; Rupanagudi, K.V.; Kulkarni, O.P.; Darisipudi, M.N.; Allam, R.; Anders, H.J.
Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in MRL-Fas(lpr) mice
J. Immunol.
187
3413-3421
2011
Homo sapiens
Toltl, L.J.; Austin, R.C.; Liaw, P.C.
Activated protein C modulates inflammation, apoptosis and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes
J. Thromb. Haemost.
9
582-592
2011
Homo sapiens
Keller, S.A.; Moore, C.C.; Clemens, M.G.; McKillop, I.H.; Huynh, T.
Activated protein C restores hepatic microcirculation during sepsis by modulating vasoregulator expression
Shock
36
361-369
2011
Homo sapiens
Kim, P.Y.; Nesheim, M.E.
Down regulation of prothrombinase by activated protein C during prothrombin activation
Thromb. Haemost.
104
61-70
2010
Homo sapiens
Wildhagen, K.C.; Lutgens, E.; Loubele, S.T.; Ten Cate, H.; Nicolaes, G.A.
The structure-function relationship of activated protein C. Lessons from natural and engineered mutations
Thromb. Haemost.
106
1034-1045
2011
Homo sapiens
Deangelis, J.P.; Varfaj, F.; Wakabayashi, H.; Fay, P.J.
The role of P4-P3 residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa
Thromb. Res.
128
470-476
2011
Homo sapiens
Hemmer, C.J.; Loebermann, M.; Unverricht, M.; Vogt, A.; Krause, R.; Reisinger, E.C.
Activated protein C protects vascular endothelial cells from apoptosis in malaria and in sepsis
Trop. Med. Int. Health
16
906-913
2011
Homo sapiens
Kowalska, M.A.; Zhao, G.; Zhai, L.; David, G.; Marcus, S.; Krishnaswamy, S.; Poncz, M.
Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation
Arterioscler. Thromb. Vasc. Biol.
34
120-126
2014
Homo sapiens
Bach, P.; Knerr, L.; Fjellstroem, O.; Hansson, K.; Mattsson, C.; Gustafsson, D.
Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia
Bioorg. Med. Chem. Lett.
24
821-827
2014
Homo sapiens
Burnier, L.; Mosnier, L.O.
Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3
Blood
122
807-816
2013
Homo sapiens
Li, B.; Yu, D.; Xu, Z.
Activated protein C inhibits amyloid beta production via promoting expression of ADAM-10
Brain Res.
1545
35-44
2014
Homo sapiens
Lee, Y.J.; Jeong, J.K.; Seol, J.W.; Xue, M.; Jackson, C.; Park, S.Y.
Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
Exp. Mol. Med.
45
e9
2013
Homo sapiens
Xue, M.; Dervish, S.; Harrison, L.C.; Fulcher, G.; Jackson, C.J.
Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice
J. Biol. Chem.
287
16356-16364
2012
Homo sapiens
D'Ursi, P.; Orro, A.; Morra, G.; Moscatelli, M.; Trombetti, G.; Milanesi, L.; Rovida, E.
Molecular dynamics and docking simulation of a natural variant of Activated Protein C with impaired protease activity: implications for integrin-mediated antiseptic function
J. Biomol. Struct. Dyn.
33
85-92
2015
Homo sapiens
Satou, M.; Nishi, Y.; Hishinuma, A.; Hosoda, H.; Kangawa, K.; Sugimoto, H.
Identification of activated protein C as a ghrelin endopeptidase in bovine plasma
J. Endocrinol.
224
61-73
2015
Bos taurus, Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Luo, L.; Lv, T.; Wang, Q.; Zhang, T.; Gu, X.; Xu, F.; Song, Y.
Activated protein C induces endoplasmic reticulum stress and attenuates lipopolysaccharide-induced apoptosis mediated by glycogen synthase kinase-3beta
Mediators Inflamm.
2012
485279
2012
Homo sapiens
Julovi, S.M.; Shen, K.; Mckelvey, K.; Minhas, N.; March, L.; Jackson, C.J.
Activated protein C inhibits proliferation and tumor necrosis factor alpha-stimulated activation of p38, c-Jun NH2-terminal kinase (JNK) and Akt in rheumatoid synovial fibroblasts
Mol. Med.
19
324-331
2013
Homo sapiens
Babu, B.I.; Genovese, T.; Mazzon, E.; Riccardi, L.; Paterniti, I.; Galuppo, M.; Crisafulli, C.; Siriwardena, A.K.; Cuzzocrea, S.
Recombinant human activated protein C (Xigris) attenuates murine cerulein-induced acute pancreatitis via regulation of nuclear factor kappaB and apoptotic pathways
Pancreas
41
619-628
2012
Homo sapiens
Maehata, Y.; Miyagawa, S.; Sawa, Y.
Activated protein C has a protective effect against myocardial I/R injury by improvement of endothelial function and activation of AKT1
PLoS ONE
7
e38738
2012
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Puig, F.; Fuster, G.; Adda, M.; Blanch, L.; Farre, R.; Navajas, D.; Artigas, A.
Barrier-protective effects of activated protein C in human alveolar epithelial cells
PLoS ONE
8
e56965
2013
Homo sapiens
Quinn, L.M.; Drakeford, C.; O'Donnell, J.S.; Preston, R.J.
Engineering activated protein C to maximize therapeutic efficacy
Biochem. Soc. Trans.
43
691-695
2015
Bos taurus (P00745), Homo sapiens (P04070), Mus musculus (P33587)
Liang, H.P.; Kerschen, E.J.; Basu, S.; Hernandez, I.; Zogg, M.; Jia, S.; Hessner, M.J.; Toso, R.; Rezaie, A.R.; Fernandez, J.A.; Camire, R.M.; Ruf, W.; Griffin, J.H.; Weiler, H.
Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice
Blood
126
2415-2423
2015
Mus musculus (P33587), Mus musculus
Gleeson, E.M.; Dichiara, M.G.; Salicio, A.; Quinn, L.M.; Drakeford, C.; Russell, S.E.; Walsh, P.T.; Orbe, J.; Hermida, J.; Smith, O.P.; O'Donnell, J.S.; Montes, R.; Preston, R.J.
Activated protein C beta-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury
Blood
126
915-919
2015
Homo sapiens (P04070), Mus musculus (P33587), Mus musculus
Griffin, J.H.; Zlokovic, B.V.; Mosnier, L.O.
Activated protein C, protease activated receptor 1, and neuroprotection
Blood
132
159-169
2018
Homo sapiens (P04070), Homo sapiens, Mus musculus (P33587), Mus musculus
Minhas, N.; Xue, M.; Jackson, C.J.
Activated protein C binds directly to Tie2 possible beneficial effects on endothelial barrier function
Cell. Mol. Life Sci.
74
1895-1906
2017
Homo sapiens (P04070)
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