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Disease on EC 3.4.21.63 - Oryzin

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3',5'-cyclic-nucleotide phosphodiesterase deficiency
Cyclic nucleotide phosphodiesterase 1C contributes to abdominal aortic aneurysm.
Abortion, Spontaneous
The immunophenotypic profile of hepatic hemopoiesis in fetuses with Down's syndrome during the second trimester of development.
Abscess
Atherogenesis and inflammation.
Clinical-pathological correlations of coronary disease progression and regression.
In situ detection of Aspergillus 18S ribosomal RNA in invasive pulmonary aspergillosis.
The role of Pseudomonas aeruginosa elastase in corneal ring abscess formation in pseudomonal keratitis.
Acantholysis
Acantholysis induced by proteolytic enzymes. I. Porcine pancreatic elastase.
Acid-Base Imbalance
[Effect of acid-base imbalance on the equilibrium of elastase and its inhibitors in rat serum and aorta tissues]
Acidosis
[Activity of elastase and its inhibitors in tissues of aorta and blood serum in various types of acidosis]
[Effect of acid-base imbalance on the equilibrium of elastase and its inhibitors in rat serum and aorta tissues]
Acne Vulgaris
Study of elastolytic activity Propionibacterium acnes and Staphylococcus epidermis in acne vulgaris and in normal skin.
Acquired Immunodeficiency Syndrome
Elastase expression by infiltrating neutrophils in gliomas.
Serum pancreatic enzymes in HIV-seropositive patients.
[A case of acute progressive pulmonary cystic disease associated with Pneumocystis carinii pneumonia in a non-HIV-infected patient]
[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]
Acute Coronary Syndrome
Early release of neutrophil markers of activation after direct stenting in patients with unstable angina.
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome.
Acute Kidney Injury
Eglin C fails to reduce catabolism in acutely uremic rats.
Neutrophil activation in acute renal failure and sepsis.
Rapid renal alpha-1 antitrypsin gene induction in experimental and clinical acute kidney injury.
Acute Lung Injury
A new elastase inhibitor from Streptococcus pneumoniae protects against acute lung injury induced by neutrophil granules.
Acute lung injury during cardiopulmonary bypass. Are the neutrophils responsible?
Acute Lung Injury in Response to Intratracheal Instillation of Lipopolysaccharide in an Animal Model of Emphysema Induced by Elastase.
Administration of alpha 1-proteinase inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Beneficial effect of an inhibitor of leukocyte elastase (EPI-hNE-4) in presence of repeated lung injuries.
Changes of length of elastic fibers in rabbit lungs after smoke inhalation injury.
Coumarinic derivatives show anti-inflammatory effects on alveolar macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo.
Dynamic balance changes between elastase and antiprotease in the early stages after smoke inhalation injury.
Effect of a polymorphonuclear elastase inhibitor (sivelestat sodium) on acute lung injury after cardiopulmonary bypass: findings of a double-blind randomized study.
Effects of human polymorphonuclear leukocyte elastase upon surfactant proteins in vitro.
Effects of nicotinamide and niacin on bleomycin-induced acute injury and subsequent fibrosis in hamster lungs.
Effects of ONO-5046, a specific neutrophil elastase inhibitor, on endotoxin-induced lung injury in sheep.
Effects of tumor necrosis factor on PMN chemotaxis, chemiluminescence, and elastase activity.
Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats.
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G.
Matrix metalloproteinase and elastase activities in LPS-induced acute lung injury in guinea pigs.
Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography.
New properties of the soybean trypsin inhibitor: Inhibition of human neutrophil elastase and its effect on acute pulmonary injury.
ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits.
Potency of truncated secretory leukoprotease inhibitor assessed in acute lung injury models in hamsters.
Preventive effect of erythromycin on experimental bleomycin-induced acute lung injury in rats.
Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
Tranexamic Acid Attenuates the Loss of Lung Barrier Function in a Rat Model of Polytrauma and Hemorrhage with Resuscitation.
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
[An aspiration pneumonia in acute airway damage model induced by HCl and/or LPS]
[Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]
[Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate]
[Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy]
Adenocarcinoma
Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.
Cell associated elastase activities of rat mammary tumour cells.
Collagenase and elastase production by mouse mammary adenocarcinoma primary cultures and cloned cells.
Determination of DNA synthesis, estrogen receptors, and carcinoembryonic antigen in isolated cellular subpopulations of human breast cancer.
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase.
Fecal elastase, an assay for exocrine pancreatic insufficiency, has clinical utility in patients with pancreatic ductal adenocarcinoma.
Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis.
Adenoma, Islet Cell
Recent results in animal models of pancreatic carcinoma: histogenesis of tumors.
Adenomyosis
[The role of innate immunity system in the course of adenomyosis].
Aggressive Periodontitis
Elastase and alpha-1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis.
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects.
Increased systemic elastase and C-reactive protein in aggressive periodontitis (CLOI-D-00160R2).
Neutrophil lysosomal nonoxidative microbicidal proteins in early-onset periodontitis.
Peripheral PMN cells in juvenile periodontitis. Increased release of elastase and of oxygen radicals after stimulation with opsonized bacteria.
[Experimental therapy of periodontosis with elastase inhibitor]
Agranulocytosis
Biocompatibility of four plasmapheresis membranes in patients treated for hypercholesterolemia.
AIDS-Related Complex
Serum pancreatic enzymes in HIV-seropositive patients.
Airway Obstruction
Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients.
Interrelationships between neutrophil elastase, serum alpha, -antitrypsin, lung function and chest radiography in patients with chronic airflow obstruction.
[Elastase and elastase inhibitors in bronchial mucus in chronic airway obstruction with reference to therapy]
Albuminuria
Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase.
Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice.
alpha 1-Antitrypsin Deficiency
Evaluation of recombinant DNA-directed E.coli produced alpha 1-antitrypsin as an anti-neutrophil elastase for potential use as replacement therapy of alpha 1-antitrypsin deficiency.
Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency.
Serum elastase inhibitor deficiency and alpha 1-antitrypsin deficiency in patients with obstructive emphysema.
The ability of serum from alpha 1-antitrypsin-deficient patients to inhibit PRT-201, a recombinant human type I pancreatic elastase.
[A study of antielastase activity in the development of pulmonary emphysema in a family with alpha 1-antitrypsin deficiency]
Alveolar Bone Loss
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
Alzheimer Disease
Elastase is associated with the neurofibrillary pathology of Alzheimer disease: a putative link between proteolytic imbalance and oxidative stress.
Amyloidosis
Amyloid fibrils trigger the release of neutrophil extracellular traps (NETs), causing fibril fragmentation by NET-associated elastase.
Neutrophil proteases associated with amyloid fibrils.
Aneurysm
A Modified Method for Creating Elastase-Induced Aneurysms by Ligation of Common Carotid Arteries in Rabbits and Its Effect on Surrounding Arteries.
A Modified Murine Abdominal Aortic Aneurysm Rupture Model using Elastase Perfusion and Angiotensin II Infusion.
A modified technique for using elastase to create saccular aneurysms in animals that histologically and hemodynamically resemble aneurysms in human.
A new murine model of endovascular aortic aneurysm repair.
A novel arterial pouch model of saccular aneurysm by concomitant elastase and collagenase digestion.
A novel chronic advanced stage abdominal aortic aneurysm murine model.
A novel coating biomaterial for intracranial aneurysms: effects and safety in extra- and intracranial carotid artery.
A Novel Modification of the Murine Elastase Infusion Model of Abdominal Aortic Aneurysm Formation.
A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation.
A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure.
A polyvinyl alcohol core coil containing basic fibroblast growth factor evaluated in rabbits with aneurysms induced by elastase.
A preliminary study of laser tissue soldering as arterial wall reinforcement in an acute experimental aneurysm model.
A rabbit model of abdominal aortic aneurysm associated with intimal thickening.
A refined experimental model of fusiform aneurysms in a rabbit carotid artery.
A refined method for creating saccular aneurysms in the rabbit.
Accuracy of optical coherence tomography imaging in assessing aneurysmal remnants after flow diversion.
Activity of alpha 1-antitrypsin and cigarette smoking in subarachnoid haemorrhage from ruptured aneurysm.
Acute mechanical effects of elastase on the infrarenal mouse aorta: implications for models of aneurysms.
Adaptive Remodeling in the Elastase-induced Rabbit Aneurysms.
Adenosine 2A receptor modulates inflammation and phenotype in experimental abdominal aortic aneurysms.
Alpha 1-antitrypsin activity in subarachnoid hemorrhage.
Altered aortic protease and antiprotease activity in patients with ruptured abdominal aortic aneurysms.
An Effective and Simple Way to Establish Elastase-Induced Middle Carotid Artery Fusiform Aneurysms in Rabbits.
An experimental aneurysm model: a training model for neurointerventionalists.
An infant with aneurysm of the thoracoabdominal aorta and blood elastase activity.
Aneurysm growth, elastinolysis, and attempted doxycycline inhibition of elastase-induced aneurysms in rabbits.
Aneurysm induced by periarterial application of elastase heals spontaneously.
Aneurysmal changes at the basilar terminus in the rabbit elastase aneurysm model.
Angiographic and histologic comparison of experimental aneurysms embolized with hydrogel filaments.
Angiographic C-arm CT visualization of the Woven EndoBridge Cerebral Aneurysm Embolization Device (WEB): First Experience in an Animal Aneurysm Model.
Anti-CD 18 monoclonal antibody slows experimental aortic aneurysm expansion.
Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation.
Are the configuration and neck morphology of experimental aneurysms predictable? A technical approach.
Arterial hypertension and aneurysmal dilatation.
Arterial wall degeneration plus hemodynamic insult cause arterial wall remodeling and nascent aneurysm formation at specific sites in dogs.
Assessment of endothelialization of aneurysm wall over time in a rabbit model through CD31 scoring.
Attenuation of experimental aortic aneurysm formation in P-selectin knockout mice.
Bare, bio-active and hydrogel-coated coils for endovascular treatment of experimentally induced aneurysms. Long-term histological and scanning electron microscopy results.
Basic fibroblast growth factor gene transfection in repair of internal carotid artery aneurysm wall.
Can aspect ratio be used to categorize intra-aneurysmal hemodynamics?--A study of elastase induced aneurysms in rabbit.
Cellular, enzymatic, and genetic factors in the pathogenesis of abdominal aortic aneurysms.
Cigarette smoking increases aortic dilatation without affecting matrix metalloproteinase-9 and -12 expression in a modified mouse model of aneurysm formation.
Collagen cross-linkage, elastolytic and collagenolytic activities in cerebral aneurysms: a preliminary investigation.
Combined endovascular coiling and intra-aneurysmal allogeneic mesenchymal stromal cell therapy for intracranial aneurysms in a rabbit model: a proof-of-concept study.
Commentary on "Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms".
Communicating malapposition of flow diverters assessed with optical coherence tomography correlates with delayed aneurysm occlusion.
Comparison of elastolytic activity between experimental aneurysm and experimental diabetes mellitus.
Comparison of the in vitro hemodynamic performance of new flow diverters for bypass of brain aneurysms.
Complications of elastase-induced arterial saccular aneurysm in rabbits: case reports and literature review.
Creating Clinically Relevant Aneurysm Sizes in the Rabbit Surgical Elastase Model.
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit.
Development of a new experimental model of saccular aneurysm by intra-arterial incubation of papain in rabbits.
Development of nanofiber-covered stents using electrospinning: in vitro and acute phase in vivo experiments.
Differential Gene Expression in Coiled versus Flow-Diverter-Treated Aneurysms: RNA Sequencing Analysis in a Rabbit Aneurysm Model.
Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
Effect of Low-Pressurized Perfusion with Different Concentration of Elastase on the Aneurysm Formation Rate in the Abdominal Aortic Aneurysm Model in Rabbits.
Effects of vascular photodynamic therapy in a newly adapted experimental rat aortic aneurysm model.
Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms.
Elastase-induced aneurysms in rabbits: effect of postconstruction geometry on final size.
Elastase-induced experimental aneurysms in rats.
Elastase-induced intracranial aneurysms in hypertensive mice.
Elastase-induced saccular aneurysms in rabbits: a dose-escalation study.
Elastase-induced saccular aneurysms in rabbits: comparison of geometric features with those of human aneurysms.
Elastase-induced suppression of endothelin-mediated Ca2+ entry mechanisms of vascular contraction.
Elastin metabolism of the infrarenal aorta.
Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model.
Endovascular creation of an in vivo bifurcation aneurysm model in rabbits.
Endovascular grafting in elastase-induced experimental aortic aneurysms in dogs: feasibility and preliminary results.
Endovascular model of abdominal aortic aneurysm induction in swine.
Endovascular treatment of experimental aneurysms in rabbits using Guglielmi detachable coils -- a feasibility study.
Endovascular treatment of experimentally induced aneurysms in rabbits using stents: a feasibility study.
Evaluation of a Second-Generation Self-Expanding Variable-Porosity Flow Diverter in a Rabbit Elastase Aneurysm Model.
Evaluation of Outcome Prediction of Flow Diversion for Intracranial Aneurysms.
Experience with Microaneurysm Formation at the Basilar Terminus in the Rabbit Elastase Aneurysm Model.
Experimental techniques and models in the study of the development and treatment of abdominal aortic aneurysm.
Extra- and Intraluminal Elastase Induce Morphologically Distinct Abdominal Aortic Aneurysms in Mice and Thus Represent Specific Subtypes of Human Disease.
Flat-detector computed tomography evaluation in an experimental animal aneurysm model after endovascular treatment: A pilot study.
Flat-detector computed tomography with intravenous contrast material application in experimental aneurysms: comparison with multislice CT and conventional angiography.
Four Surgical Modifications to the Classic Elastase Perfusion Aneurysm Model Enable Haemodynamic Alterations and Extended Elastase Perfusion.
From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment.
Gender differences in experimental aortic aneurysm formation.
Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Haemorrhagic tracheal necrosis as a lethal complication of an aneurysm model in rabbits via endoluminal incubation with elastase.
HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.
Healing response in elastase-induced rabbit aneurysms after embolization with a new platinum coil system.
High coincidence of inguinal hernias and abdominal aortic aneurysms.
Histologic evaluation of platinum coil embolization in an aneurysm model in rabbits.
Hypertension accelerates the growth of experimental aortic aneurysms.
In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.
In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model.
Increased PAI-1 in Females Compared to Males is Protective for Abdominal Aortic Aneurysm Formation in a Rodent Model.
Inhibition of inducible nitric oxide synthase limits nitric oxide production and experimental aneurysm expansion.
Inhibition of interleukin-1? decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms.
Inhibition of Receptor-Interacting Protein Kinase 1 with Necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model.
Inhibition of VEGF (Vascular Endothelial Growth Factor)-A or its Receptor Activity Suppresses Experimental Aneurysm Progression in the Aortic Elastase Infusion Model.
Left ventricular pseudoaneurysm and alpha1-antitrypsin enzyme deficiency: Another pathological correlation.
Long-term histological and scanning electron microscopy results of endovascular and operative treatments of experimentally induced aneurysms in the rabbit.
Magnetic Microparticles for Endovascular Aneurysm Treatment: In-Vitro and In-Vivo Experimental Results.
Matrix metalloproteinase haplotypes associated with coronary artery aneurysm formation in patients with Kawasaki disease.
Mechanical instability of normal and aneurysmal arteries.
Mesenchymal Stem Cells Exhibit Both a Proinflammatory and Anti-Inflammatory Effect on Saccular Aneurysm Formation in a Rabbit Model.
Metalloproteases and intracranial vascular lesions.
Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension.
Morphologic changes in the aorta during elastase infusion in the rat aneurysm model.
MR imaging of myeloperoxidase activity in a model of the inflamed aneurysm wall.
mRNA expression in rabbit experimental aneurysms: a study using gene chip microarrays.
Multimodal imaging in the elastase-induced aneurysm model in rabbits: a comparative study using serial DSA, MRA and CTA.
Multimodality imaging assessment of the deleterious role of the intraluminal thrombus on the growth of abdominal aortic aneurysm in a rat model.
Neck Injury Is Critical to Elastase-Induced Aneurysm Model.
Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation.
New ascending aortic aneurysm model in rats reproduces main structural features of degenerative ascending thoracic aortic aneurysms in human beings.
Nitric oxide in experimental aneurysm formation: early events and consequences of nitric oxide inhibition.
Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice.
Onyx in an experimental aneurysm model: histological and angiographic results.
Oral Presentations of the 2016 Annual Meeting of the Congress of Neurological Surgeons: San Diego, California: September 24-28, 2016: 100?Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
Paradoxical neutrophil elastase release in endovascular abdominal aortic aneurysm repair.
peri-Adventitial delivery of smooth muscle cells in porous collagen scaffolds for treatment of experimental abdominal aortic aneurysm.
Porcine Model of Infrarenal Abdominal Aortic Aneurysm.
Preclinical Evaluation of the Accero Stent: Flow Remodelling Effect on Aneurysm, Vessel Reaction and Side Branch Patency.
Preclinical safety and efficacy evaluation of the Pipeline Vantage Embolization Device with Shield Technology.
Preclinical Testing of a Novel Thin Film Nitinol Flow-Diversion Stent in a Rabbit Elastase Aneurysm Model.
Rabbit aneurysm model mediated by the application of elastase.
Rabbit aortic aneurysm model with enlarging diameter capable of better mimicking human aortic aneurysm disease.
Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing.
Rapamycin suppresses experimental aortic aneurysm growth.
Rapid saccular aneurysm induction by elastase application in vitro.
Recombinant Interleukin-19 Suppresses the Formation and Progression of Experimental Abdominal Aortic Aneurysms.
Regression of abdominal aortic aneurysms by simultaneous inhibition of nuclear factor kappaB and ets in a rabbit model.
Relationship between proteolytic enzymes and atherosclerosis in aortic aneurysms.
Ruptured mesenteric artery aneurysm in a patient with alpha 1-antitrypsin deficiency: etiologic implications.
Saccular aneurysm induction by elastase digestion of the arterial wall: a new animal model.
Saccular aneurysms on straight and curved vessels are subject to different hemodynamics: implications of intravascular stenting.
Safety and performance of the Penumbra Liberty stent system in a rabbit aneurysm model.
Sensitivity of CFD based hemodynamic results in rabbit aneurysm models to idealizations in surrounding vasculature.
Serum elastase and alpha-1-antitrypsin levels in patients with ruptured and unruptured cerebral aneurysms.
Shortened elastase infusion time in the elastase-induced rat aneurysm model.
Simvastatin suppresses experimental aortic aneurysm expansion.
Smooth Muscle Peroxisome Proliferator-Activated Receptor ? Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo.
Successful serial imaging of the mouse cerebral arteries using conventional 3-T magnetic resonance imaging.
Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses.
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms.
Testing Stenting and Flow Diversion Using a Surgical Elastase-Induced Complex Fusiform Aneurysm Model.
The asymmetric vascular stent: efficacy in a rabbit aneurysm model.
The effects of mesenchymal stem cells on the structure and contractile force of the carotid artery in a rat aneurysm model
Thermoreversible gelation polymer as an embolic material for aneurysm treatment: a delivery device for dermal fibroblasts and basic fibroblast growing factor into experimental aneurysms in rats.
Time-of-flight-, phase contrast and contrast enhanced magnetic resonance angiography for pre-interventional determination of aneurysm size, configuration, and neck morphology in an aneurysm model in rabbits.
Treatment of experimentally induced aneurysms with stents.
Treatment of rabbit carotid aneurysms by hybrid stents (microporous thin polyurethane-covered stents): Preservation of side-branches.
Treatment of wide-necked aneurysms with balloon-expandable polyurethane-covered stentgrafts: experience in an animal model.
Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation.
Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice.
Ubiquitous elevation of matrix metalloproteinase-2 expression in the vasculature of patients with abdominal aneurysms.
[A retrospective study of ruptured abdominal aortic aneurysms--association with respiratory function and leukocytic granular elastase]
[Aneurysmal model induced by elastase]
[Effects of elastase on experimentally induced aneurysms in rats]
[Elastase imbalance: alpha-1 antitrypsin in aneurysms]
Aneurysm, Dissecting
Carotid artery dissection in a young adult: cystic medial necrosis associated with an increased elastase content.
Aneurysm, Ruptured
A Modified Murine Abdominal Aortic Aneurysm Rupture Model using Elastase Perfusion and Angiotensin II Infusion.
Absence of plasma protease-antiprotease imbalance in the formation of saccular cerebral aneurysms.
Elastin metabolism of the infrarenal aorta.
From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment.
Serum elastase and alpha-1-antitrypsin levels in patients with ruptured and unruptured cerebral aneurysms.
Angina Pectoris
Increased pericardial fluid level of matrix metalloproteinase-9 activity in patients with acute myocardial infarction: possible role in the development of cardiac rupture.
Tissue plasminogen activator and leucocyte elastase as predictors of cardiovascular events in subjects with angina pectoris: Edinburgh Artery Study.
Angina, Stable
Acute neutrophil activation in direct stenting: comparison of stable and unstable angina patients.
Granulocyte activation after coronary angioplasty in humans.
Neutrophil function in ischemic heart disease.
Spontaneous superoxide generation by polymorphonuclear leukocytes isolated from patients with stable angina after physical exercise.
Angina, Unstable
Acute neutrophil activation in direct stenting: comparison of stable and unstable angina patients.
Early release of neutrophil markers of activation after direct stenting in patients with unstable angina.
Neutrophil function in ischemic heart disease.
Plasma leukocyte elastase concentration in angiographically diagnosed coronary artery disease.
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
Anthrax
Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.
Complexed plasma elastase as an in vivo marker for leukocyte activation in antineutrophil cytoplasmic antibody-associated vasculitis.
Endothelial tissue factor stimulation by proteinase 3 and elastase.
Aortic Aneurysm
A new serum proteolytic enzyme in aneurysm pathogenesis.
Activities of proteases in parietal thrombus of aortic aneurysm.
Altered aortic protease and antiprotease activity in patients with ruptured abdominal aortic aneurysms.
Arterial hypertension and aneurysmal dilatation.
Development of a novel murine model of aortic aneurysms using peri-adventitial elastase.
Early MT-1 MMP expression following elastase exposure is associated with increased cleaved MMP-2 activity in experimental rodent aortic aneurysms.
Elastase activity: the role of elastase in aortic aneurysm formation.
Factors influencing mortality in the rat elastase-induced-aneurysm model.
In situ localization and quantification of seventy-two-kilodalton type IV collagenase in aneurysmal, occlusive, and normal aorta.
Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1.
Porcine Model of Infrarenal Abdominal Aortic Aneurysm.
Ruptured mesenteric artery aneurysm in a patient with alpha 1-antitrypsin deficiency: etiologic implications.
Targeted Gold Nanoparticles as an Indicator of Mechanical Damage in an Elastase Model of Aortic Aneurysm.
The elastase infusion model of experimental aortic aneurysms: synchrony of induction of endogenous proteinases with matrix destruction and inflammatory cell response.
Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm.
Aortic Aneurysm, Abdominal
A Modified Murine Abdominal Aortic Aneurysm Rupture Model using Elastase Perfusion and Angiotensin II Infusion.
A Novel Modification of the Murine Elastase Infusion Model of Abdominal Aortic Aneurysm Formation.
A novel rat model of abdominal aortic aneurysm using a combination of intraluminal elastase infusion and extraluminal calcium chloride exposure.
A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters.
Abdominal aortic aneurysm: association between haptoglobin phenotypes, elastase activity, and neutrophil count in the peripheral blood.
Activated forms of MMP2 and MMP9 in abdominal aortic aneurysms.
Activation of transglutaminase type 2 for aortic wall protection in a rat abdominal aortic aneurysm formation.
Altered aortic protease and antiprotease activity in patients with ruptured abdominal aortic aneurysms.
AT2R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat.
Biomechanical consequences of compromised elastic fiber integrity and matrix cross-linking on abdominal aortic aneurysmal enlargement.
Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation.
Can the infusion of elastase in the abdominal aorta of the Yucatán miniature swine consistently produce experimental aneurysms?
Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice.
Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice.
Change in high-sensitive C-reactive protein during abdominal aortic aneurysm formation.
Characterization of human aortic elastase found in patients with abdominal aortic aneurysms.
Commentary on 'Performance of a modified rabbit model of abdominal aortic aneurysm induced by topical application of porcine elastase: 5-month follow-up study'.
Creation of murine experimental abdominal aortic aneurysms with elastase.
Development of a novel murine model of aortic aneurysms using peri-adventitial elastase.
Development of a novel rabbit model of abdominal aortic aneurysm via a combination of periaortic calcium chloride and elastase incubation.
Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency.
Effect of Low-Pressurized Perfusion with Different Concentration of Elastase on the Aneurysm Formation Rate in the Abdominal Aortic Aneurysm Model in Rabbits.
Effects of calcium channel blocker azelnidipine on experimental abdominal aortic aneurysms.
Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms.
Elastase is not sufficient to induce experimental abdominal aortic aneurysms.
Elastic fibers reconstructed using adenovirus-mediated expression of tropoelastin and tested in the elastase model of abdominal aortic aneurysm in rats.
Elastin metabolism of the infrarenal aorta.
Experimental modifications to a canine infrarenal aortic aneurysm model for the validation of endovascular stent-grafts: an exploratory study.
Extra- and Intraluminal Elastase Induce Morphologically Distinct Abdominal Aortic Aneurysms in Mice and Thus Represent Specific Subtypes of Human Disease.
Indomethacin prevents elastase-induced abdominal aortic aneurysms in the rat.
Inhibition of AAA in a rat model by treatment with ACEI perindopril.
Inhibitory effects of doxycycline on the onset and progression of abdominal aortic aneurysm and its related mechanisms.
Intraluminal infusion of Penta-Galloyl Glucose reduces abdominal aortic aneurysm development in the elastase rat model.
Leukocyte and serum elastase in response to elective surgical trauma.
Leukocyte mimetic polysaccharide microparticles tracked in vivo on activated endothelium and in abdominal aortic aneurysm.
Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1.
Morphologic changes in the aorta during elastase infusion in the rat aneurysm model.
Morphological and Biomechanical Differences in the Elastase and AngII apoE(-/-) Rodent Models of Abdominal Aortic Aneurysms.
Nanoparticles Effectively Target Rapamycin Delivery to Sites of Experimental Aortic Aneurysm in Rats.
Natural history of abdominal aortic aneurysm with and without coexisting chronic obstructive pulmonary disease.
Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume.
Nicotine-stimulated elastase activity release by neutrophils in patients with abdominal aortic aneurysms.
Novel experimental model of enlarging abdominal aortic aneurysm in rabbits.
Overexpression of TIMP-2 mediated by recombinant adenovirus in rat abdominal aorta inhibits extracellular matrix degradation.
Performance of a modified rabbit model of abdominal aortic aneurysm induced by topical application of porcine elastase: 5-month follow-up study.
Pharmacological Inhibition of Cathepsin S Suppresses Abdominal Aortic Aneurysm in Mice.
Reduced capacity to inhibit elastase in abdominal aortic aneurysm.
Relationship between inflammation and progression of an abdominal aortic aneurysm in a rabbit model based on 18F-FDG PET/CT imaging.
Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration.
Role of cathepsin C in elastase-induced mouse abdominal aortic aneurysms.
Role of the neutrophil in abdominal aortic aneurysm development.
Smooth muscle cell elastase, atherosclerosis, and abdominal aortic aneurysms.
Spatiotemporal mapping of matrix remodelling and evidence of in situ elastogenesis in experimental abdominal aortic aneurysms.
Systemic levels of cotinine and elastase, but not pulmonary function, are associated with the progression of small abdominal aortic aneurysms.
Tamsulosin attenuates abdominal aortic aneurysm growth.
Telmisartan prevents aneurysm progression in the rat by inhibiting proteolysis, apoptosis and inflammation.
The calcium messenger system and the kinetics of elastase release from human neutrophils in patients with abdominal aortic aneurysms.
The creation of an infrarenal aneurysm within the native abdominal aorta of swine.
The significance of chymase in the progression of abdominal aortic aneurysms in dogs.
[Examination of elastase concentration in the wall of abdominal aortic aneurysms]
[Natural history of abdominal aortic aneurysm with and without concomitant chronic obstructive pulmonary disease]
Aortic Aneurysm, Thoracic
A reproducible swine model of proximal descending thoracic aortic aneurysm created with intra-adventitial application of elastase.
Commentary on "Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms".
Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm.
Aortic Coarctation
Novel experimental model of enlarging abdominal aortic aneurysm in rabbits.
Aortic Diseases
Altered aortic protease and antiprotease activity in patients with ruptured abdominal aortic aneurysms.
Change in elastin structure in human aortic connective tissue diseases.
Elastin metabolism of the infrarenal aorta.
Urinary L-valyl proline in patients with aortic aneurysms.
Aortic Rupture
[A retrospective study of ruptured abdominal aortic aneurysms--association with respiratory function and leukocytic granular elastase]
Aortic Valve Stenosis
Rabbit aortic aneurysm model with enlarging diameter capable of better mimicking human aortic aneurysm disease.
Appendicitis
Leucocyte elastase as a marker in the diagnosis of acute appendicitis.
White blood cell count, leucocyte elastase activity, and serum concentrations of interleukin-6 and C-reactive protein after open appendicectomy.
Arteriosclerosis
Change in the elastase content of the pancreas in relation to arteriosclerosis.
Immunomodulating effect of low density lipoprotein on human monocytes.
[Activity of elastase and its inhibitors in arterial tissues and blood serum under experimental arterio-atherosclerosis]
[Changes in the activity of elastase and its inhibitors in the aorta tissue and blood serum of rats with streptozocin-induced diabetes]
[Elastin, elastase and arteriosclerosis]
[Structural alterations triggered by certain enzymes (lipase, elastase, mucopolysaccharidase) in the course of experimental arteriosclerosis in rabbits]
[The balance of elastase and its inhibitors in the vascular tissues of rabbits of different ages in the early stages of experimental Mönckeberg-type arteriosclerosis]
[The effect of the elastase on aminonucleoside nephrosis]
[Vascular aging. Role of elastin receptor]
Arteriosclerosis Obliterans
Effect of elastase on primary graft patency after femoralpopliteal arterial bypass for arteriosclerosis obliterans: a randomized, controlled study.
Arteritis
Elastase derived elastin peptides: putative autoimmune targets in giant cell arteritis.
Elastolytic activity of human monocytes: rheumatological aspects.
Arthritis
Antigen induced arthritis in beige (Chediak-Higashi) mice.
Aromatic trap analysis of free radicals production in experimental collagen-induced arthritis in the rat: protective effect of glycosaminoglycans treatment.
Arthritis induced immunologically with cationic amidated bovine serum albumin in the guinea pig. A morphological and biochemical study on the destruction of articular cartilage.
Beneficial effect of 20?hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen?induced arthritis: A model for rheumatoid arthritis.
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Chondroitin-4-sulphate inhibits NF-kB translocation and caspase activation in collagen-induced arthritis in mice.
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Detecting Migration and Infiltration of Neutrophils in Mice.
Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix.
Effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on elastase and hyaluronidase activities and its type II collagen expression.
Elastase and collagenase activities in synovial fluid of patients with arthritis.
Elastolytic activity of human blood monocytes characterized by a new monoclonal antibody against human leucocyte elastase. Relationship to rheumatoid arthritis.
In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens.
Leech thrombin inhibitors.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Molecular elucidation of pancreatic elastase inhibition by baicalein.
Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.
Triphala exhibits anti-arthritic effect by ameliorating bone and cartilage degradation in adjuvant-induced arthritic rats.
[Induction of arthritis in healthy knee joints after intra-articular injection of the proteolytic enzyme elastase - An experimental investigation in the rabbit]
Arthritis, Experimental
Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats.
Effects of low molecular weight chondroitin sulfate on type II collagen-induced arthritis in DBA/1J mice.
Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration.
Arthritis, Gouty
Curcumin ameliorates monosodium urate-induced gouty arthritis through Nod-like receptor 3 inflammasome mediation via inhibiting nuclear factor-kappa B signaling.
Arthritis, Juvenile
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis, Rheumatoid
Activity of some lysosomal enzyme in rheumatoid and psoriatic arthritis.
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis.
Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Circulating human leucocyte elastase in rheumatoid arthritis.
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment.
Correlation between erythrocyte CR1 reduction and other blood proteinase markers in patients with malignant and inflammatory disorders.
Correlation between the appearance of gelatinases in the synovial fluid of patients with rheumatoid arthritis and polymorphonuclear elastase, stromelysin-1, and the tissue inhibitor of metalloproteinase-1.
Decreased Interleukin-1? and Elastase in the Gingival Crevicular Fluid of Individuals Undergoing Anti-Inflammatory Treatment for Rheumatoid Arthritis.
Decreased interleukin-1beta and elastase in the gingival crevicular fluid of individuals undergoing anti-inflammatory treatment for rheumatoid arthritis.
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Degradation in vivo of articular cartilage in rheumatoid arthritis by leucocyte elastase from polymorphonuclear leucocytes.
Destruction of articular cartilage by alpha 2 macroglobulin elastase complexes: role in rheumatoid arthritis.
Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix.
Detection of granulocyte elastase specific IgG split products in rheumatoid synovial fluid.
Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats.
Elastase activity in cartilage extracts and synovial fluids from subjects with osteoarthritis or rheumatoid arthritis: the prominent role of metalloproteinases.
Elastase activity in serum and synovial fluid of patients with connective tissue disorders.
Elastase from polymorphonuclear leukocyte in articular cartilage and synovial fluids of patients with rheumatoid arthritis.
Elastolytic activity of human blood monocytes characterized by a new monoclonal antibody against human leucocyte elastase. Relationship to rheumatoid arthritis.
Elastolytic activity of human monocytes: rheumatological aspects.
Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases.
Impaired activity of protease inhibitors towards neutrophil elastase bound to human articular cartilage.
Impaired glutathione reductase activity and levels of collagenase and elastase in synovial fluid in rheumatoid arthritis.
Inactivation of the elastase inhibitory activity of alpha 1 antitrypsin in fresh samples of synovial fluid from patients with rheumatoid arthritis.
Inhibition of leucocyte elastase by heparin and its derivatives.
Interference of cartilage surface with interaction of granulocyte elastase with alpha 1-proteinase inhibitor. An in vitro model of enzyme inhibition in the joint space.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Measurement of proteoglycans, elastase, collagenase and protein in synovial fluid in inflammatory and degenerative arthropathies.
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Neutral protease, collagenase and elastase activities in synovial fluids from arthritic patients.
Plasma levels of inhibitor-bound leukocytic elastase in rheumatoid arthritis patients.
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
The inhibitory effects of antirheumatic drugs on the activity of human leukocyte elastase and cathepsin G.
The Natural Polypeptides as Significant Elastase Inhibitors.
The role of neutrophil elastase in chronic inflammation.
[Macroglobulin alpha-2 in synovial fluid: relationship with reactants of the acute phase of rheumatoid arthritis]
Arthus Reaction
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase.
Studies on the role of polymorphonuclear leukocyte granule elastase in Arthus reaction.
Aspergillosis
Correlation of elastase production by some strains of Aspergillus fumigatus with ability to cause pulmonary invasive aspergillosis in mice.
Elastase production in clinical isolates of Aspergillus.
Importance of elastase production in development of invasive aspergillosis.
Investigation of extracellular elastase, acid proteinase and phospholipase activities as putative virulence factors in clinical isolates of Aspergillus species.
Isolation, characterization, and cloning of cDNA and the gene for an elastinolytic serine proteinase from Aspergillus flavus.
The effect of elastase-specific monoclonal and polyclonal antibodies on the virulence of Aspergillus fumigatus in immunocompromised mice.
Western blot detection of IgG anti-Aspergillus fumigatus elastase in sera of patients with aspergillosis.
X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus.
[Aspergillosis: Mechanisms of pathogenicity implicated and approach to laboratory diagnosis.]
[Investigation of acid proteinase and phospholipase activity as virulence factors in clinical Aspergillus spp. isolates].
Asthma
Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD.
Alfa 1 antitrypsin and protease levels in Puerto Rican asthmatics: a pilot study.
Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor.
Effect of age and asthma duration upon elastase and alpha1-antitrypsin levels in adult asthmatics.
Elastase binding capacity of alpha 2-macroglobulin in plasma of patients with asthma or chronic obstructive pulmonary disease, without alpha 1-protease inhibitor deficiency.
Exposure levels of asthmatic children to allergens, endotoxins, and serine proteases in a tropical environment.
Human neutrophil-derived elastase induces airway smooth muscle cell proliferation.
Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients.
Role of neutrophil elastase in hypersecretion in asthma.
Stimulated elastase release from human leukocytes: influence of anti-asthmatic, anti-inflammatory and calcium antagonist drugs in vitro.
Systemic upregulation of neutrophil {alpha}-defensins and serine proteases in neutrophilic asthma.
The Natural Polypeptides as Significant Elastase Inhibitors.
The neutrophil and chronic allergic inflammation. Immunochemical localization of neutrophil elastase.
[Elastase and alpha-1 proteinase inhibitor complex in broncho-alveolar lavage fluid in patients with bronchial asthma and sarcoidosis]
[Eosinophil and neutrophil degranulation in allergic inflammation: immunohistochemical localization of granule proteins in fatal asthma and stimulus-dependent degranulation in vitro]
[The Churg-Strauss syndrome]
Astrocytoma
Elastase expression by infiltrating neutrophils in gliomas.
Ataxia Telangiectasia
Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms.
Atherosclerosis
Abdominal aortic aneurysm: association between haptoglobin phenotypes, elastase activity, and neutrophil count in the peripheral blood.
Activity of leucocyte elastase in women with coronary artery disease documented using angiography.
Aging of the vascular wall: serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA study.
Anti-atherosclerotic action of elastase--with special reference to its effect on elastic fibres.
Biological properties of pancreatic elastase in relation to atherosclerotic disease.
Combination of Periaortic Elastase Incubation and Cholesterol-Rich Diet: A Novel Model of Atherosclerosis in Rabbit Abdominal Aorta.
Effect of elastase on aortic smooth muscle cell proliferation.
Elastase in the prevention of arterial aging and the treatment of atherosclerosis.
Elastase-type activity of human serum. Its variation in chronic obstructive lung diseases and atherosclerosis.
Enhanced macrophage uptake of elastase-modified high-density lipoproteins.
Enzymes related to atherosclerosis especially elastase and atherosclerosis.
Evaluation of plasmatic leucocyte elastase levels in coronary artery disease.
Influence of Crystalline Elastase on Experimental Atherosclerosis in the Chicken.
Investigations of fluorescent peptides and lipofuscins of human intervertebral disc relating to atherosclerosis.
Promotive effect of elastase on regression of aortic atherosclerosis in cholesterol-fed quails.
Protective action of elastase on changes in mechanical properties of vascular smooth muscles during atherosclerogenesis in hypercholesterolemic rabbits.
Relation of serum elastase activity to ultrasonographically assessed carotid artery wall lesions and cardiovascular risk factors. The EVA study.
Scavenger effect of elastase on calcifications in liver, kidney and central nervous system tissues of rabbits with atherosclerosis induced by cholesterol-rich diet.
Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques: the Etude sur le Vieillissement Artériel (EVA) study.
Smooth muscle cell elastase, atherosclerosis, and abdominal aortic aneurysms.
The effect of elastase on chickens with endogenous hyperlipidemia.
The Natural Polypeptides as Significant Elastase Inhibitors.
The possible implications of enzymes of the elastase complex in atherosclerosis.
The possible implications of the enzymes of the elastase complex in the process of atherosclerosis.
[Action of elastase on experimental atherosclerosis. Preliminary note]
[Activity of elastase and its inhibitors in arterial tissues and blood serum under experimental arterio-atherosclerosis]
[Changes in the activity of elastase and its inhibitors in the aorta tissue and blood serum of rats with streptozocin-induced diabetes]
[Correlation between age, arteriosclerosis and elastinolytic activity of human aorta wall]
[Effect of an enzyme combination of elastase and elastomucoproteinase on experimental atherosclerosis in rabbits]
[Elastase activity in man and atherosclerosis]
[Elastolysis, aging and atherogenesis]
[Experimental studies on the effect of elastase on atherosclerosis]
[Improvements in the technical conditions for the evaluation of an elastolytic activity. The role of tryspin as an activator (author's transl)]
[Protease inhibitors and ectasia in coronary atherosclerosis]
[Protective action of elastase on experimental atherosclerosis of the rabbit.]
[Serum elastin peptide concentration and human leukocyte elastase/antiproteinase balance in peripheral obstructive atherosclerosis]
[Studies on the action of elastase; effect of elastase on the metabolism of lipids and connective tissues in experimental atherosclerosis]
[The inhibitory effect of elastase on calcium increase in brain and spinal cord of rabbits with atherosclerosis induced by cholesterol-rich diet]
Atrial Fibrillation
Use of minimal extracorporeal circulation improves outcome after heart surgery; a systematic review and meta-analysis of randomized controlled trials.
Autoimmune Diseases
Antibodies to neutrophil elastase: a study in patients with vasculitis.
Avian Leukosis
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
Bacteremia
Bacterial and host factors affecting Pseudomonas aeruginosa colonization versus bacteremia in granulocytopenic patients.
Relative contribution of three main virulence factors in Pseudomonas aeruginosa pneumonia.
Serum antibody concentrations of cytotoxin, exotoxin, A, lipopolysaccharide, protease, and elastase and survival of patients with Pseudomonas aeruginosa bacteremia.
Bacterial Infections
Capillary plasma neutrophil elastase alpha-1-proteinase inhibitor as infection parameter in neonates.
Comparative cleavage sites within the reactive-site loop of native and oxidized alpha1-proteinase inhibitor by selected bacterial proteinases.
Detection and Characterization of Antimicrobial Resistance and Putative Virulence Genes in Aeromonas veronii Biovar Sobria Isolated from Gilthead Sea Bream (Sparus aurata L.).
Effect of collection and preprocessing methods on neutrophil elastase plasma concentrations.
Effects of elastase, protease and common antigen (OEP) from Pseudomonas aeruginosa on protection against burns in mice.
Elastase alpha 1-proteinase inhibitor and lactoferrin concentrations in endotracheal aspirates of ventilated newborns.
Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation.
Bernard-Soulier Syndrome
Reevaluation of the presence of the major antigen Ca++ complex in Bernard-Soulier syndrome platelets. Elastase degradation of the complex in Bernard-Soulier syndrome platelet preparations.
beta-Thalassemia
Neutrophil elastase in patients with homozygous beta-thalassemia and pseudoxanthoma elasticum-like syndrome.
Blister
Decreased specific anti-elastase activity in the uninvolved skin of patients with psoriasis.
Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid.
Histogenesis of abnormal elastic fibers in blebs and bullae of patients with spontaneous pneumothorax: ultrastructural and immunohistochemical studies.
Monitoring of elastase in plasma of burned patients in relation to other inflammation parameters.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
The generation of a human dermal equivalent to assess the potential contribution of human dermal fibroblasts to the sulphur mustard-induced vesication response.
[A case of acute progressive pulmonary cystic disease associated with Pneumocystis carinii pneumonia in a non-HIV-infected patient]
Bone Diseases
Dietary modulation of the microbiome affects autoinflammatory disease.
Bone Resorption
Identification of a novel bone/calcium metabolism-regulating factor in porcine pancreas.
Brain Diseases
Processing of whole femoral head allografts: a method for improving clinical efficacy and safety.
Brain Injuries, Traumatic
Polymorphonuclear (PMN) elastase in patients after severe traumatic brain injury.
Brain Ischemia
Involvement of Progranulin and Granulin Expression in Inflammatory Responses after Cerebral Ischemia.
Possible involvement of progranulin in the protective effect of elastase inhibitor on cerebral ischemic injuries of neuronal and glial cells.
Breast Neoplasms
Alpha 1-antitrypsin blocks the release of transforming growth factor-alpha from MCF-7 human breast cancer cells.
Biomimetic Liposome with Surface-Bound Elastase for Enhanced Tumor Penetration and Chemo-Immumotherapy.
Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy.
Cyclin E in breast tumors is cleaved into its low molecular weight forms by calpain.
Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.
Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.
Elastase digestion of the amyloid-like substance surrounding mammary cancer and basal cell carcinoma of the skin.
Human tumor cell urokinase-type plasminogen activator (uPA): degradation of the proenzyme form (pro-uPA) by granulocyte elastase prevents subsequent activation by plasmin.
Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase.
Production of immunoreactive polymorphonuclear leucocyte elastase in human breast cancer cells: possible role of polymorphonuclear leucocyte elastase in the progression of human breast cancer.
Structural Diversity and Anticancer Activity of Marine-Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer.
Target protein interactions of indole-3-carbinol and the highly potent derivative 1-Benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.
Bronchial Diseases
The interrelationship of sputum inflammatory markers in patients with chronic bronchitis.
Bronchial Hyperreactivity
Participation of collagenase and elastase in LPS-induced airway hyperresponsiveness in guinea pigs.
Bronchiectasis
A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.
Bronchial inflammation and colonization in patients with clinically stable bronchiectasis.
Delivery of Alpha-1 Antitrypsin to Airways.
Effect of antibiotic treatment on sputum elastase in bronchiectatic outpatients in a stable clinical state.
Effects of human neutrophil elastase and Pseudomonas aeruginosa proteinases on human respiratory epithelium.
Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.
Elastolytic activity of sputum and its relation to purulence and to lung function in patients with bronchiectasis.
In vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion.
Neutrophil Elastase Activity is Associated with Exacerbations and Lung Function Decline in Bronchiectasis.
Neutrophil inflammation and activation in bronchiectasis: comparison with pneumonia and idiopathic pulmonary fibrosis.
Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase.
Neutrophils from subjects with chronic obstructive lung disease show enhanced chemotaxis and extracellular proteolysis.
Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis.
Reduction of ciliary beat frequency in vitro by sputum from patients with bronchiectasis: a serine proteinase effect.
Sputum elastase in steady-state bronchiectasis.
Sputum sol neutrophil elastase activity in bronchiectasis: differential modulation by syndecan-1.
Sputum sol phase proteins and elastase activity in patients with clinically stable bronchiectasis.
The response of patients with purulent bronchiectasis to antibiotics for four months.
Towards precision medicine in bronchiectasis: what is the role of neutrophilic elastase determination?
Bronchiolitis
Barotrauma susceptibility in hamster lungs following elastase exposure.
IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis.
Neutrophil elastase and obliterative bronchiolitis.
[An experimental pathological study of the effect of bronchiolitis on emphysema and cor pulmonale pathogenesis]
[Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]
Bronchitis
Elastase inhibitors of sputum sol phase: variability, relationship to neutrophil elastase inhibition, and effect of corticosteroid treatment.
Interaction of granulocyte proteases with inhibitors in pulmonary diseases.
Serum studies of leucocyte elastase in acute and chronic lung diseases.
[Elastase and acid phosphatase activity in bronchoalveolar lavage fluid during chronic bronchitis]
[Evaluation of matrix metaloproteinases (pro-mMP-1, MMP-2,8) and their inhibitor (TIMP-1) contents in patients with occupational lung diseases]
[Impaired balance of the lung proteolytic system in patients with pneumoconiosis and chronic dust-induced bronchitis]
[Plasma elastase alpha 1-proteinase inhibitor complex in children with bronchitis]
[Prospects of etiological diagnosis of bronchitis]
[Status of the protease inhibitor system in patients with dust-induced lung diseases]
Bronchitis, Chronic
Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema.
Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema.
Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients.
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
The hamster as a model of chronic bronchitis and emphysema in man.
[Elastase activity in bronchoalveolar lavage fluid from patients with diffuse panbronchiolitis]
[Elastase and acid phosphatase activity in bronchoalveolar lavage fluid during chronic bronchitis]
[Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters]
Bronchopneumonia
Human neutrophil elastase: degradation of basement membrane components and immunolocalization in the tissue.
Interaction of granulocyte proteases with inhibitors in pulmonary diseases.
Bronchopulmonary Dysplasia
Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia.
Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice.
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
Elastase Inhibitory Activity of Airway ?1-Antitrypsin is Protected by Treatment with a Catalytic Antioxidant in a Baboon Model of Severe Bronchopulmonary Dysplasia.
Oxygen exposure in the newborn guinea pig lung lavage cell populations, chemotactic and elastase response: a possible relationship to neonatal bronchopulmonary dysplasia.
Persistent elastase/proteinase inhibitor imbalance during prolonged ventilation of infants with bronchopulmonary dysplasia: evidence for the role of nosocomial infections.
Protease inhibitors in bronchoalveolar lavage fluid from neonates with special reference to secretory leukocyte protease inhibitor.
Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia.
Targeting elastase in bronchopulmonary dysplasia.
Bronchopulmonary Sequestration
In vivo effects of intravascularly applied Escherichia coli hemolysin: dissociation between induction of granulocytopenia and lethality in monkeys.
Carcinoma
Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents.
Characterization of the elastase 1-simian virus 40 T-antigen mouse model of pancreatic carcinoma: effects of sex and diet.
Cholecystokinin receptor characterization and cholecystokinin-A receptor messenger RNA expression in transgenic mouse pancreatic carcinomas and dysplastic pancreas.
Concentrations of protease and anti-protease in serum of patients with pancreatic cancer.
Diagnostic value of serum elastase 1 in pancreatic disease.
Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis.
Elastase digestion of the amyloid-like substance surrounding mammary cancer and basal cell carcinoma of the skin.
Elastase levels in small and non-small cell lung carcinoma.
Evaluation of serum pancreatic enzymes, carbohydrate antigen 19-9, and carcinoembryonic antigen in various pancreatic diseases.
Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins.
Human neutrophil defensin and serpins form complexes and inactivate each other.
Hyperplasia and tumors of the islets of Langerhans in mice bearing an elastase I-SV40 T-antigen fusion gene.
Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus.
Influence of heparin thromboprophylaxis on plasma leucocyte elastase levels following lobectomy for lung carcinoma.
Involvement of protein kinase C and an elastase-like enzyme in the processing of transforming growth factor-alpha in human colon carcinoma cell lines.
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Novel expression of gastrin (CCK-B) receptors in pancreatic carcinomas and dysplastic pancreas from transgenic mice.
Plasma elastase levels in the elderly.
Proteomic analysis and characterisation of human cervico-vaginal fluid proteins.
Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes.
Recent results in animal models of pancreatic carcinoma: histogenesis of tumors.
Serine protease inhibitor activity of recombinant squamous cell carcinoma antigen towards chymotrypsin, as demonstrated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Significance of tissue laminin P(1) elastase and fibronectin levels in transitional cell carcinoma of the bladder.
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis.
[Assay of serum elastase 1 in adenocarcinoma of the pancreas: diagnostic value, compared and combined study with serum CEA and CA 19-9]
[Elastase activity during growth and metastasis of tumors andthe pharmacological effects in C57Bl/6 mice]
[New aspects of the diagnosis of pancreatic cancer by determination of granulocyte elastase]
[Successful Surgical Resection of Expansive-Growth Acinar Cell Carcinoma-A Case Report].
Carcinoma, Acinar Cell
Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents.
Cholecystokinin receptor characterization and cholecystokinin-A receptor messenger RNA expression in transgenic mouse pancreatic carcinomas and dysplastic pancreas.
Novel expression of gastrin (CCK-B) receptors in pancreatic carcinomas and dysplastic pancreas from transgenic mice.
[Successful Surgical Resection of Expansive-Growth Acinar Cell Carcinoma-A Case Report].
Carcinoma, Basal Cell
Elastase digestion of the amyloid-like substance surrounding mammary cancer and basal cell carcinoma of the skin.
Carcinoma, Hepatocellular
A case of ruptured hepatoma followed by elastase-induced disseminated intravascular coagulation.
Elastase binding capacity of alpha 2-macroglobulin and its association with glucocorticoid concentration in southern African black patients with hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Elastase levels in small and non-small cell lung carcinoma.
Carcinoma, Pancreatic Ductal
Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.
Carcinoma, Renal Cell
Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant.
Carcinoma, Squamous Cell
Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis.
Gene structure, chromosomal localization, and expression of the murine homologue of human proteinase inhibitor 6 (PI-6) suggests divergence of PI-6 from the ovalbumin serpins.
Immunohistochemical expression of SKALP/elafin in squamous cell carcinoma of the oesophagus.
Proteomic analysis and characterisation of human cervico-vaginal fluid proteins.
Proteomic analysis of human cervicovaginal fluid collected before preterm premature rupture of the fetal membranes.
Serine protease inhibitor activity of recombinant squamous cell carcinoma antigen towards chymotrypsin, as demonstrated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Carcinoma, Transitional Cell
Significance of tissue laminin P(1) elastase and fibronectin levels in transitional cell carcinoma of the bladder.
Cardiac Output, Low
Use of minimal extracorporeal circulation improves outcome after heart surgery; a systematic review and meta-analysis of randomized controlled trials.
Cardiomyopathies
Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function.
Cardiovascular Diseases
Aging of the vascular wall: serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA study.
Leech thrombin inhibitors.
Neutrophil Elastase-Generated Fragment of Vascular Endothelial Growth Factor-A Stimulates Macrophage and Endothelial Progenitor Cell Migration.
Oenothera paradoxa defatted seeds extract and its bioactive component penta-O-galloyl-?-D-glucose decreased production of reactive oxygen species and inhibited release of leukotriene B4, interleukin-8, elastase, and myeloperoxidase in human neutrophils.
Serum elastase inhibitors in cardio-vascular diseases.
Carotid Artery Diseases
Correction: Production of IL-8, VEGF and Elastase by Circulating and Intraplaque Neutrophils in Patients with Carotid Atherosclerosis.
Polymorphonuclear leukocyte elastase in patients with stroke.
Production of IL-8, VEGF and Elastase by Circulating and Intraplaque Neutrophils in Patients with Carotid Atherosclerosis.
Carotid Stenosis
Production of IL-8, VEGF and Elastase by Circulating and Intraplaque Neutrophils in Patients with Carotid Atherosclerosis.
Cataract
Chemical modification of alpha crystallin.
cathepsin g deficiency
Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.
cathepsin k deficiency
Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice.
Central Nervous System Infections
Neutrophil Extracellular Traps (NETs) in the Cerebrospinal Fluid Samples from Children and Adults with Central Nervous System Infections.
Chediak-Higashi Syndrome
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
Neutrophils in beige mice secrete normal amounts of cathepsin G and a 46 kDa latent form of elastase that can be activated extracellularly by proteolytic activity.
Cholelithiasis
Effects of cholecystectomy (laparoscopic versus open) on PMN-elastase.
Cholera
Comparison of the Vibrio cholerae hemagglutinin/protease and the Pseudomonas aeruginosa elastase.
Cholestasis
Serum Level of D-Lactate in Patients with Cystic Fibrosis: Preliminary Data.
Chorioamnionitis
Fluctuations in elastase of cervical mucus and clinical efficacy of cefodizime in obstetric and gynecologic infections.
Induction of hepatic granulopoiesis due to chorioamnionitis during the second trimester of development.
Protease production by microorganisms associated with reproductive tract infection.
[Importance of plasma PMN granulocyte elastase concentration determination in pregnant patients with premature rupture of fetal membranes]
Chronic Periodontitis
Active and alpha-1 proteinase inhibitor complexed leukocyte elastase levels in crevicular fluid from patients with periodontal diseases.
alpha 1-Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline.
Collagenase, gelatinase and elastase activities in sulcular fluid of osseointegrated implants and natural teeth.
Effect of cigarette smoking on oral elastase activity in adult periodontitis patients.
Effects on the clinical indices and gingival crevicular fluid enzyme activities of the cyclical regimen of low-dose doxycycline therapy for adult periodontitis.
Elastase and alpha-1-proteinase inhibitor in gingival crevicular fluid and gingival tissue in adult and juvenile periodontitis.
Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis.
Erratum: Elastase and metalloproteinase 9 concentrations in saliva in patients with chronic periodontitis.
Expression of intracellular elastase activity in peripheral neutrophils from patients with adult periodontitis.
Increased release of elastase from in vitro activated peripheral neutrophils in patients with adult periodontitis.
Localization of active and inactive elastase, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin in human gingiva.
Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients.
Non-surgical periodontal therapy decreases serum elastase levels in aggressive but not in chronic periodontitis.
Proteolytic enzymes as indicators of periodontal health in gingival crevicular fluid of patients with Sjögren's syndrome.
Secretory leukocyte protease inhibitor and its potential interactions with elastase and cathepsin B in gingival crevicular fluid and saliva from patients with chronic periodontitis.
[Changes of elastase in gingival crevicular fluid after periodontal treatment of adult periodontitis patients]
Churg-Strauss Syndrome
[Antineutrophil cytoplasmic antibodies--ANCA]
chymotrypsin deficiency
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Pancreatic dysfunction and its association with fat malabsorption in HIV infected children.
Ciliary Motility Disorders
Delivery of Alpha-1 Antitrypsin to Airways.
Coinfection
An intracellular interaction between a temperature-sensitive mutant and the original wild-type HVJ (sendai virus) is responsible for the establishment and maintenance of HVJ persistent infection.
Avian influenza virus h3 hemagglutinin may enable high fitness of novel human virus reassortants.
Co-infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice.
Serum antibody response to Pseudomonas aeruginosa antigens during corneal infection.
[The synergism of Actinobacillus pleuropneumoniae and influenza A virus in experimentally-infected mice]
Colic
Assessment of systemic inflammation by time-trends of blood granulocyte count and plasma myeloperoxidase and elastase concentrations following colic surgery in horses.
Colitis
Hyaluronan reduces colitis-induced intraperitoneal inflammation during peritoneal dialysis.
Intracolonic release in vivo of interleukin-1 beta in chronic ulcerative colitis.
Pancreatic and granulocytic endoproteases in faecal extracts from patients with active ulcerative colitis.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Colitis, Ulcerative
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Circulating human leucocyte elastase in patients with inflammatory bowel disease.
Faecal elastase reflects disease activity in active ulcerative colitis.
Human Neutrophil Elastase Proteolytic Activity in Ulcerative Colitis Favors the Loss of Function of Therapeutic Monoclonal Antibodies.
Leucocyte elastase in chronic inflammatory bowel diseases: a marker of inflammatory activity?
Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity?
p-ANCA target antigens in ulcerative colitis.
Pancreatic and granulocytic endoproteases in faecal extracts from patients with active ulcerative colitis.
PMN-elastase in assessment of patients with inflammatory bowel disease.
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
Secretory leukocyte protease inhibitor in punch biopsies from human colonic mucosa.
TGF-?1 and granulocyte elastase in the evaluation of activity of inflammatory bowel disease. A pilot study.
Colorectal Neoplasms
Polymorphonuclear elastase in human colorectal carcinoma.
Serum proteolytic activities and antiproteases in human colorectal carcinoma.
Common Variable Immunodeficiency
Common variable immunodeficiency patients display elevated plasma levels of granulocyte activation markers elastase and myeloperoxidase.
Communicable Diseases
Biomarkers for the Discrimination of Acute Kawasaki Disease From Infections in Childhood.
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Soluble T-lymphocyte antigen-specific immunoproteins: a progress report.
Conjunctivitis
Genetic features of Pseudomonas aeruginosa isolates associated with eye infections referred to Farabi Hospital, Tehran, Iran.
Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis.
[Quantitative elastase determination in tear fluid in conjunctivitis]
Connective Tissue Diseases
Elastase activity in serum and synovial fluid of patients with connective tissue disorders.
[Changes in elastase and collagenase serum levels in patients with sclerosing connective tissue diseases treated with uropancreozymin]
Contracture
Biomechanical properties of normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Biomechanical properties of normal tendons, normal palmar aponeuroses, and tissues from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Corneal Diseases
Pseudomonas aeruginosa proteases and corneal virulence.
Corneal Injuries
Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa.
Corneal Ulcer
Effect of phosphoramidon on protection against corneal ulcer caused by elastase and protease from Pseudomonas aeruginosa.
Coronary Artery Disease
Activity of leucocyte elastase in women with coronary artery disease documented using angiography.
Evaluation of plasmatic leucocyte elastase levels in coronary artery disease.
In vitro and in vivo evidence for the role of elastase shedding of CD163 in human atherothrombosis.
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
[Modulators of leukocytic functions]
Coronary Disease
Evaluation of oxidative status in coronary heart disease at baseline and during exercise test.
Increased systemic elastase and C-reactive protein in aggressive periodontitis (CLOI-D-00160R2).
Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques: the Etude sur le Vieillissement Artériel (EVA) study.
[Protease inhibitors and ectasia in coronary atherosclerosis]
COVID-19
Anti-Inflammatory, Antiallergic, and COVID-19 Main Protease (Mpro) Inhibitory Activities of Butenolides from a Marine-Derived Fungus Aspergillus terreus.
Elastase and exacerbation of neutrophil innate immunity are involved in multi-visceral manifestations of COVID-19.
Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19.
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity.
Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy.
Crohn Disease
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Circulating human leucocyte elastase in patients with inflammatory bowel disease.
Faecal elastase reflects disease activity in active ulcerative colitis.
Leucocyte elastase in chronic inflammatory bowel diseases: a marker of inflammatory activity?
Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity?
PMN-elastase in assessment of patients with inflammatory bowel disease.
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
TGF-?1 and granulocyte elastase in the evaluation of activity of inflammatory bowel disease. A pilot study.
[Clinical features of different variants of excretory pancreatic insufficiency]
Cross Infection
Inhibitors of elastase in airway lavage samples from ventilated preterm human neonates.
Cutis Laxa
Increased fibroblast elastase activity in acquired cutis laxa.
Cystic Fibrosis
13C-Mixed Triglyceride Breath Test and Fecal Elastase as an Indirect Pancreatic Function Test in Cystic Fibrosis Infants.
A 33 kDa serine proteinase from Scedosporium apiospermum.
Alginate, the slime exopolysaccharide of Pseudomonas aeruginosa, binds human leukocyte elastase, retards inhibition by alpha 1-proteinase inhibitor, and accelerates inhibition by secretory leukoprotease inhibitor.
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Alpha-1 Antitrypsin Therapy in Cystic Fibrosis and the Lung Disease Associated with Alpha-1 Antitrypsin Deficiency.
alpha1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients.
Antineutrophil elastase activity in cystic fibrosis serum.
Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis.
Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Biofilm dispersal cells of a cystic fibrosis Pseudomonas aeruginosa isolate exhibit variability in functional traits likely to contribute to persistent infection.
Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis.
Characteristics of EPI-hNE4 aerosol: a new elastase inhibitor for treatment of cystic fibrosis.
Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts.
Comparison of four procedures for measuring elastase production by Pseudomonas aeruginosa strains from cystic fibrosis patients.
Comparison of monoclonal and polyclonal ELISAs for fecal elastase in patients with cystic fibrosis and pancreatic insufficiency.
Comparison of urinary desmosine excretion in patients with chronic obstructive pulmonary disease or cystic fibrosis.
Concentrations of trypsin, elastase and carbohydrate antigen CA 19-9 in serum of cystic fibrosis patients.
Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors.
Delivery of Alpha-1 Antitrypsin to Airways.
DNase I acutely increases cystic fibrosis sputum elastase activity and its potential to induce lung hemorrhage in mice.
Effect of nebulised recombinant DNase on neutrophil elastase load in cystic fibrosis.
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
Elastase alpha 1-antiproteinase complexes in cystic fibrosis.
Elastase as a potential biomarker for radiation-induced gut wall injury of the distal bowel in an experimental mouse model.
Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children.
Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis.
EPI-hNE4, a proteolysis-resistant inhibitor of human neutrophil elastase and potential anti-inflammatory drug for treating cystic fibrosis.
Evidence that Pseudomonas aeruginosa elastase does not inactivate the bronchial inhibitor in the presence of leukocyte elastase. Studies with cystic fibrosis sputum and with pure proteins.
Evolution of Pancreatic Function during the First Year in Infants with Cystic Fibrosis.
Expression of MIG/CXCL9 in cystic fibrosis and modulation of its activities by elastase of Pseudomonas aeruginosa.
Expression patterns of genes encoding elastase and controlling mucoidy: co-ordinate regulation of two virulence factors in Pseudomonas aeruginosa isolates from cystic fibrosis.
Fecal elastase: pancreatic status verification and influence on nutritional status in children with cystic fibrosis.
Gallium induces the production of virulence factors in Pseudomonas aeruginosa.
Granulocyte elastase-alpha 1-antiproteinase complex in cystic fibrosis: sensitive plasma assay for monitoring pulmonary infections.
Granulocyte elastase-mediated proteolysis of alpha 1-antitrypsin in cystic fibrosis bronchopulmonary secretions.
High variability in quorum quenching and growth inhibition by furanone C-30 in Pseudomonas aeruginosa clinical isolates from cystic fibrosis patients.
Immunoenzymometric assays for alkaline protease and exotoxin A from Pseudomonas aeruginosa: development and use in detecting exoproteins in clinical isolates from patients with cystic fibrosis.
Increased elastase secretion by peripheral blood monocytes in cystic fibrosis patients.
Increased levels of IgG subclasses specific for Pseudomonas aeruginosa exoenzyme and polysaccharide antigens in chronically infected patients with cystic fibrosis.
Interleukin-8 induces neutrophil accumulation but not protease secretion in the canine trachea.
Longitudinal study of immune response to Pseudomonas aeruginosa antigens in cystic fibrosis.
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Measurement of fecal elastase improves performance of newborn screening for cystic fibrosis.
Molecular typing and biological characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Brazil.
Nasal secretion analysis in allergic rhinitis, cystic fibrosis, and nonallergic fibromyalgia/chronic fatigue syndrome subjects.
New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.
Nutritional management of cystic fibrosis patients.
Patterns of neutrophil serine protease-dependent cleavage of surfactant protein D in inflammatory lung disease.
Polysulfated Hyaluronan GlycoMira-1111 Inhibits Elastase and Improves Rheology in Cystic Fibrosis Sputum.
Population transcript accumulation of Pseudomonas aeruginosa exotoxin A and elastase in sputa from patients with cystic fibrosis.
Production of elastase, exotoxin A, and alkaline protease in sputa during pulmonary exacerbation of cystic fibrosis in patients chronically infected by Pseudomonas aeruginosa.
Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways.
Prolastin aerosol therapy and sputum taurine in cystic fibrosis.
Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis.
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
Proteases of Pseudomonas aeruginosa in patients with cystic fibrosis.
Pseudomonas aeruginosa and cystic fibrosis: correlation between exoenzyme production and patient's clinical state.
Pulmonary deposition and disappearance of aerosolised secretory leucocyte protease inhibitor.
Re: fecal elastase: pancreatic status verification and influence on nutritional status in children with cystic fibrosis.
Recombinant human Monocyte/Neutrophil elastase inhibitor protects rat lungs against injury from cystic fibrosis airway secretions.
Regulation of cytokine secretion by cystic fibrosis airway epithelial cells.
Relation between antibody response to Pseudomonas aeruginosa exoproteins and colonization/infection in patients with cystic fibrosis.
Respiratory infections with Pseudomonas aeruginosa in children with cystic fibrosis: early detection by serology and assessment of risk factors.
SerpinB1 in CF airway fluids: quantity, molecular form and mechanism of elastase inhibition.
Sputum sol-phase proteins and elastase activity in patients with cystic fibrosis.
Stool elastase as a diagnostic test for pancreatic function in children with cystic fibrosis.
Study of biological characteristics of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis and from patients with extra-pulmonary infections.
Subinhibitory antibiotics reduce Pseudomonas aeruginosa tissue injury in the rat lung model.
The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10.
The I-neb Adaptive Aerosol Delivery System enhances delivery of alpha1-antitrypsin with controlled inhalation.
The Natural Polypeptides as Significant Elastase Inhibitors.
The role of neutrophil elastase in chronic inflammation.
Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum.
Update on the evaluation of pancreatic exocrine status in cystic fibrosis.
Vaccination promotes TH1-like inflammation and survival in chronic Pseudomonas aeruginosa pneumonia. A new prophylactic principle.
[Alginate, elastase and alkaline protease production of Pseudomonas aeruginosa strains isolated from various body sites]
[An alpha 1-antitrypsin aerosol in the treatment of cystic fibrosis]
[Anti-tensile power of serum with an elevated elastase level in mucoviscidosis in children and its variations in adult emphysema]
[Production of elastase, exotoxin A and alkaline protease during bronchopulmonary exacerbations in patients with mucoviscidosis chronically infected by Pseudomonas aeruginosa]
Cysts
Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary lymphangioleiomyomatosis (LAM).
Lactoferrin in aspirates of odontogenic cyst fluid.
Cytomegalovirus Infections
Serum pancreatic enzymes in HIV-seropositive patients.
Decompression Sickness
Cyclical bending movements induced locally by successive iontophoretic application of ATP to an elastase-treated flagellar axoneme.
Dehydration
Applicability of using acrylic resins in post-embedding ultrastructural immunolabelling of human neutrophil granule proteins.
Dementia
Increased elastase and cathepsin G activity in activated lymphocytes from aged patients Role of denutrition and dementia.
Dengue
Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation.
Plasma Neutrophil Elastase, ?1-Antitrypsin, ?2-Macroglobulin and Neutrophil Elastase-?1-Antitrypsin Complex Levels in patients with Dengue Fever.
Dental Plaque
Fibronectin fragmentation induced by dental plaque and Bacteroides gingivalis.
Dental Pulp Diseases
Human polymorphonuclear granule components: relative levels detected by a modified enzyme-linked immunosorbent assay in normal and inflamed dental pulps.
Dermatitis
Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid.
Dermatitis Herpetiformis
Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid.
Dermatitis, Atopic
Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis.
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.
Dermatitis, Contact
In vitro and in vivo effects of Ranunculus peltatus subsp. baudotii methanol extract on models of eicosanoid production and contact dermatitis.
Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis.
Diabetes Mellitus
Atrophy of remnant pancreas after pancreatoduodenectomy: Risk factors and effects on quality of life, nutritional status, and pancreatic function.
Autoimmune pancreatitis: Functional and morphological recovery after steroid therapy.
Changes in FGF-23, Neutrophil/Platelet Activation Markers, and Angiogenin in Advanced Chronic Kidney Disease and Their Effect on Arterial Stiffness.
Duodenal-preserving resection of the head of the pancreas and pancreatic head resection with second-portion duodenectomy for benign lesions, low-grade malignancies, and early carcinoma involving the periampullary region.
Effects of oral elastase on lipid metabolism, platelet function, and blood coagulability in patients with diabetes mellitus.
Fulminant diabetes mellitus associated with pregnancy: case reports and literature review.
High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients.
Joint Measurements of Leukocyte Elastase and Myeloperoxidase Promote Identification of the State of Neutrophils in Diabetic Patients.
Plasma leukocyte elastase concentration in angiographically diagnosed coronary artery disease.
Proteinases in catabolism and malnutrition.
Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations.
Studies on proteolytic activities in heart muscle of diabetic rats.
The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1? and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
[Changes in the activity of elastase and its inhibitors in the aorta tissue and blood serum of rats with streptozocin-induced diabetes]
[Elastolytic system of the pancreas in modelling diabetes mellitus]
[Fibrinolysis modulators]
[Neutrophils as a source of factors that increase the length of the inflammatory phase of wound healing in patients with type 2 diabetes mellitus].
[Pancreatic exocrine function in diabetes mellitus: Determination of fecal elastase.]
Diabetes Mellitus, Experimental
[Effects of repeated administration of elastase on lungs of rats with experimental diabetes mellitus]
[Elastolytic system of the pancreas in modelling diabetes mellitus]
Diabetes Mellitus, Type 1
Autoantibodies and endothelial dysfunction in well-controlled, uncomplicated insulin-dependent diabetes mellitus patients.
Exocrine Pancreas Dysfunction in Type 1 Diabetes.
Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3.
Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young.
Diabetes Mellitus, Type 2
Clinical experience with exenatide in predominantly Asian and Pacific Islander patients with type 2 diabetes.
Crevicular fluid elastase levels in relation to periodontitis and metabolic control of diabetes.
Joint Measurements of Leukocyte Elastase and Myeloperoxidase Promote Identification of the State of Neutrophils in Diabetic Patients.
Pancreatic exocrine insufficiency is not common in HNF-1alpha MODY.
The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1? and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.
[Neutrophils as a source of factors that increase the length of the inflammatory phase of wound healing in patients with type 2 diabetes mellitus].
[Possible participation of angiotensin-converting enzyme and leukocyte elastase in the pathogenesis of insulin-independent diabetes mellitus]
[Serum elastase I and amylase concentrations in non-insulin-dependent diabetes mellitus]
Diabetes, Gestational
[Elastase of polymorphonuclear granulocytes. Determination in plasma in pregnancy and following premature rupture of the membranes]
Diabetic Foot
Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers.
Diabetic Nephropathies
Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis.
[Inhibitory effect of elastase on diabetic nephropathy in experimental diabetic mice]
Digestive System Diseases
Succinyl trialanine p-nitroanilide-hydrolytic enzymes in human serum. Partial purification and characterization.
Diphtheria
Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene.
Discitis
PMN granulocyte elastase--an early indicator of postoperative spondylodiscitis?
[Procalcitonin (PCT) as diagnostic tool for the monitoring of spondylodiscitis]
Disseminated Intravascular Coagulation
A case of ruptured hepatoma followed by elastase-induced disseminated intravascular coagulation.
Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with disseminated intravascular coagulation.
[Disseminated intravenous coagulation in acute necrotizing pancreatitis]
Down Syndrome
The immunophenotypic profile of hepatic hemopoiesis in fetuses with Down's syndrome during the second trimester of development.
Duodenal Ulcer
A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: its application to the measurement of granulocyte-derived elastase digests in plasma.
Dupuytren Contracture
Biomechanical properties of normal tendons, normal palmar aponeuroses and palmar aponeuroses from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Biomechanical properties of normal tendons, normal palmar aponeuroses, and tissues from patients with Dupuytren's disease subjected to elastase and chondroitinase treatment.
Dyskinesias
[Acute bacterial exacerbation of chronic obstructive pulmonary disease and biofilm]
Dyslipidemias
Evaluation of plasmatic leucocyte elastase levels in coronary artery disease.
Eclampsia
Analysis of plasma elastase levels in early and late onset preeclampsia.
Correlated plasma elastase and sera cytotoxicity in eclampsia. A possible role of endothelin-1 induced neutrophil activation in preeclampsia-eclampsia.
Ehlers-Danlos Syndrome
Serum elastase inhibitor levels in Ehlers-Danlos syndrome.
Empyema
Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions.
Factors influencing length of hospital stay in patients with bacterial pleural effusion.
Empyema, Pleural
Cleavage of C3 by neutral proteases from granulocytes in pleural empyema.
Endometriosis
Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-? (Gro-?) from endometrioma stromal cells.
Endometritis
The In Vitro Inhibitory Effect of Sivelestat on Elastase Induced Collagen and Metallopeptidase Expression in Equine Endometrium.
Endophthalmitis
Biological activities of partially purified elastase produced by Flavobacterium meningosepticum.
Endotoxemia
Intestinal permeability changes, systemic endotoxemia, inflammatory serum markers and sepsis after Whipple's operation for carcinoma of the pancreas head.
Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers.
Enteritis
Low fecal elastase: potentially related to transient small bowel damage resulting from enteric pathogens.
Eosinophilia
[The Churg-Strauss syndrome]
Epidermolysis Bullosa Acquisita
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.
Erythema
Faecal enzymes: in vivo human skin irritation.
Lesional elastase activity in psoriasis. Diagnostic and prognostic significance.
Esophageal Neoplasms
Pulmonary hypertension and polymorphonuclear leukocyte elastase after esophageal cancer operations.
[ARDS-like reactive respiratory failure after radical operation for esophageal cancer--with reference to PMN elastase and anaphylatoxin]
[Responses of cytokines, acute phase proteins, and polymorphonuclear cell elastase to surgical stress in the patients with esophageal cancer]
Exocrine Pancreatic Insufficiency
13C-starch breath test--comparative clinical evaluation of an indirect pancreatic function test.
Alterations of bone mineral density and bone metabolism in patients with various grades of chronic pancreatitis.
Cathodal elastase in duodenal juice from children with gastrointestinal disorders.
Comparative clinical evaluation of the 13C-mixed triglyceride breath test as an indirect pancreatic function test.
Comparison of fecal elastase 1 for exocrine pancreatic insufficiency evaluation between ex-alcoholics and chronic pancreatitis patients.
Comparison of fecal elastase-1 determination with the secretin-cholecystokinin test in patients with cystic fibrosis.
Comparison of monoclonal and polyclonal ELISAs for fecal elastase in patients with cystic fibrosis and pancreatic insufficiency.
Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues.
Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis.
Duodenal-preserving resection of the head of the pancreas and pancreatic head resection with second-portion duodenectomy for benign lesions, low-grade malignancies, and early carcinoma involving the periampullary region.
Effect of intestinal inflammation on fecal elastase concentration in dogs.
Endoscopic Ultrasound Finding of Diffuse Echogenicity in the Pancreas, Is It Relevant?
Evaluation of Fecal Elastase and Serum Cholecystokinin in Dogs with a False Positive Fecal Elastase Test.
Exocrine pancreatic function is preserved in systemic sclerosis.
Faecal Calprotectin in Cystic Fibrosis and IT'S Relation to Disease Parameters - a Longitudinal Analysis Over 12 Years.
Faecal elastase 1: a novel, highly sensitive, and specific tubeless pancreatic function test.
Fecal elastase, an assay for exocrine pancreatic insufficiency, has clinical utility in patients with pancreatic ductal adenocarcinoma.
Fecal pancreatic elastase in infants under 2 years of age.
Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients.
High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. A multicenter study screening fecal elastase 1 concentrations in 1,021 diabetic patients.
Immunoreactive elastase I: clinical evaluation of a new noninvasive test of pancreatic function.
Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms?
Molecular diagnosis of shwachman-diamond syndrome presenting with pancytopenia at an early age: the first report from Turkey.
New faecal tests in gastroenterology.
Nutritional management of cystic fibrosis patients.
Pancreatic elastase 1 in stool: variations within one stool passage and individual changes from day to day.
Pancreatic exocrine insufficiency in HIV-positive patients.
Pancreatic exocrine insufficiency: diagnostic evaluation and replacement therapy with pancreatic enzymes.
Pancreatic Insufficiency is Not a Prevalent Problem in Alagille Syndrome.
Response to "Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues".
Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis.
Specificity of a Polyclonal Fecal Elastase ELISA for CELA3.
The baseline nutritional status assessed by MUST score has a low accuracy in predicting the risk of hospitalization during follow-up in patients with chronic pancreatitis: A cohort study.
The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study.
Transient Exocrine Pancreatic Insufficiency in Children: An Existing Entity?
Undiagnosed Pancreatic Exocrine Insufficiency and Chronic Pancreatitis in Functional GI Disorder Patients with Diarrhea or Abdominal pain.
Update on the evaluation of pancreatic exocrine status in cystic fibrosis.
[Effectiveness of fecal elastase 1 in diagnosis of the external secretion of the pancreas]
[Measurement of fecal elastase 1 by immunoreactivity: a new indirect test of the pancreatic function]
[New fecal markers: recent developments and perspectives]
[Pancreatic infringement exocrine and endocrine in cystic fibrosis].
Fatigue Syndrome, Chronic
Unravelling intracellular immune dysfunctions in chronic fatigue syndrome: interactions between protein kinase R activity, RNase L cleavage and elastase activity, and their clinical relevance.
Fetal Growth Retardation
Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.
Fibrosarcoma
A modified enzymatic technique for production of cell suspensions of a murine fibrosarcoma.
Activity of lysosomal and nonlysosomal proteases of fibrosarcoma induced by methylcholanthrene.
Food Hypersensitivity
Expression of IL-17A concentration and effector functions of peripheral blood neutrophils in food allergy hypersensitivity patients.
Foot Rot
Use of elastase test, gelatin gel test and electrophoretic zymogram to determine virulence of Dichelobacter nodosus isolated from ovine foot rot.
Foot Ulcer
Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers.
Gastrointestinal Diseases
Cathodal elastase in duodenal juice from children with gastrointestinal disorders.
Effect of intestinal inflammation on fecal elastase concentration in dogs.
Fecal Calprotectin, Elastase, and Alpha-1-Antitrypsin Levels After Roux-en-Y Gastric Bypass; Calprotectin Is Significantly Elevated in the Majority of Patients.
Genetic Diseases, Inborn
Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease.
Giant Cell Arteritis
Elastase derived elastin peptides: putative autoimmune targets in giant cell arteritis.
Elastolytic activity of human monocytes: rheumatological aspects.
Gingival Pocket
Oxygen-dependent modulation of release and activity of polymorphonuclear leukocyte granule products.
The effect of treatment on the activity of salivary proteases and glycosidases in adults with advanced periodontitis.
Gingivitis
Activity and inhibition of elastase in GCF.
Association of crevicular fluid elastase-like activity with histologically-confirmed attachment loss in ligature-induced periodontitis in beagle dogs.
Changes of Four Proinflammatory Proteins in Whole Saliva during Experimental Gingivitis.
Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.
Elastase and lactoferrin in gingival crevicular fluid: possible indicators of a granulocyte-associated specific host response.
Elastase release from gingival crevicular and peripheral neutrophils in periodontitis and health.
Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis.
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects.
In vitro release of elastase from human blood and gingival crevicular neutrophils.
Microassay for the detection of elastase activity in the gingival crevice.
Oral fluid elastase as an indicator of periodontal health.
The relationship between elastase and lactoferrin in healthy, gingivitis and periodontitis sites.
Variations in crevicular fluid elastase levels in periodontitis patients on long-term maintenance.
Glioblastoma
Elastase expression by infiltrating neutrophils in gliomas.
Glioma
Elastase expression by infiltrating neutrophils in gliomas.
[Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases]
Glomerulonephritis
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders.
Antibodies to neutrophil granulocyte myeloperoxidase and elastase: autoimmune responses in glomerulonephritis due to hydralazine treatment.
Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis.
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Elastase deposits in the kidney and urinary elastase excretion in patients with glomerulonephritis - evidence for neutrophil involvement in renal injury.
Interaction of myeloperoxidase and elastase enzyme activity with the antihypertensive agents hydralazine and dihydralazine.
Occurrence of autoantibodies directed against myeloperoxidase and elastase in patients treated with hydralazine and presenting with glomerulonephritis.
PR3 and Elastase Alter PAR1 Signaling and Trigger vWF Release via a Calcium-Independent Mechanism from Glomerular Endothelial Cells.
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis.
Glomerulonephritis, Membranoproliferative
Occurrence of autoantibodies directed against myeloperoxidase and elastase in patients treated with hydralazine and presenting with glomerulonephritis.
Gout
Neutral protease, collagenase and elastase activities in synovial fluids from arthritic patients.
Granuloma
Characterization of elastase associated with granulomatous tissue remodeling.
Clinical value of an automated granulocyte elastase assay in predicting severity of acute pancreatitis.
Collagenase, elastase, and nonspecific protease production by vigorous or immunomodulated liver granulomas and granuloma macrophages/eosinophils of S mansoni-infected mice.
Elastase activity in granulomatous inflammation in experimental murine leprosy.
In vivo activity of proteases of Pseudomonas aeruginosa in a rat model.
Management of inflammation: the parametrical system, its practical and methodological position.
Observations on Pseudomonas aeruginosa proteolytic and toxic activity in experimentally infected rats.
Vaccine efficacies of elastase, exotoxin A, and outer-membrane protein F in preventing chronic pulmonary infection by Pseudomonas aeruginosa in a rat model.
[Pulmonary schistosomiasis. Identification and determination of elastase in platelets and its role in the development of Schistosoma mansoni granuloma]
[The relation between the growth and extracellular proteolytic activity in trichophyton rubrum, comparing isolates from granuloma trichophyticum with tinea superficialis]
Granulomatosis with Polyangiitis
Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity.
Detachment and cytolysis of human endothelial cells by proteinase 3.
Eosinophil and neutrophil degranulation in ophthalmic lesions of Wegener's granulomatosis.
Occurrence of autoantibodies to human leucocyte elastase in Wegener's granulomatosis and other inflammatory disorders.
Granulomatous Disease, Chronic
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
The effect of oxidants on neutrophil-mediated degradation of glomerular basement membrane collagen.
Graves Disease
Pyoderma gangrenosum with secondary pyarthrosis following propylthiouracil.
Hearing Disorders
[Hearing disorders in children less than 16 months of age after bacterial meningitis with reference to cerebrospinal fluid elastase]
Hearing Loss
[Hearing disorders in children less than 16 months of age after bacterial meningitis with reference to cerebrospinal fluid elastase]
Heart Arrest
Increased neutrophil elastase release in patients with cardiopulmonary arrest: role of elastase inhibitor.
Reperfusion after cardioplegic cardiac arrest--effects on intracoronary leucocyte elastase release and oxygen free radical mediated lipid peroxidation.
Heart Diseases
Interleukin-8 release and neutrophil degranulation after pediatric cardiopulmonary bypass.
Heart Failure
Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients.
Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure.
HELLP Syndrome
Immunohistological study in cases of HELLP syndrome (hemolysis, elevated liver enzymes and low platelets) and acute fatty liver of pregnancy.
Hematologic Neoplasms
[Investigation of acid proteinase and phospholipase activity as virulence factors in clinical Aspergillus spp. isolates].
Hemolytic-Uremic Syndrome
Elevated serum elastase and alpha-1-antitrypsin levels in hemolytic uremic syndrome.
Hemoptysis
[Clinical analysis of chronic pulmonary aspergillosis and discovery of a elastase inhibitor]
[Treatment of chronic pulmonary aspergillosis (fungus ball type, mural thickness type)]
Hemorrhagic Disorders
Elastase mediated fibrinolysis in acute promyelocytic leukemia.
Hepatitis
A case of ruptured hepatoma followed by elastase-induced disseminated intravascular coagulation.
Hepatitis A
[Viral hepatitis A and the possible pathogenetic mechanisms of a protracted convalescence]
Hepatitis, Chronic
[Blood concentration of granulocytic elastase, surgical invasion and postoperative complications--with special reference to surgical resection of liver cirrhosis]
Hernias, Diaphragmatic, Congenital
Elastase and matrix metalloproteinase activities are associated with pulmonary vascular disease in the nitrofen rat model of congenital diaphragmatic hernia.
Herpes Zoster
A survey of the effects of proteases and glycosidases on culture of rabbit morulae to blastocysts.
Hyperalgesia
Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.
Exercise-induce hyperalgesia, complement system and elastase activation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome - a secondary analysis of experimental comparative studies.
Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Hypercalcemia
The effect of primary hyperparathyroidism on pancreatic exocrine function.
Hypercholesterolemia
Antiatheromatous properties of elastase in cholesterol-fed rabbits and ex vivo suppressive effect of elastase on smooth muscle cell proliferation in the presence of hypercholesterolemia.
Combination of Periaortic Elastase Incubation and Cholesterol-Rich Diet: A Novel Model of Atherosclerosis in Rabbit Abdominal Aorta.
Hyperemia
Alterations of filtration coefficients in pulmonary edema of different pathogenesis.
Hypergammaglobulinemia
Multispecific anti neutrophil cytoplasm antibodies: a case report.
Hyperglycemia
Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia.
Hyperlipidemias
The effect of elastase on chickens with endogenous hyperlipidemia.
[Clinical effect of oral pancreatic extracts containing elastase in essential hyperlipemia.]
[EFFECT OF ELASTASE ON CHOLESTEROL-INDUCED LIPEMIA IN RABBITS.]
[The effect of the elastase on aminonucleoside nephrosis]
Hyperlipoproteinemias
[Changes in the proteinase-inhibitor system of rats with hyperlipoproteinemia during transcerebral exposures to a 100-Hz-frequency pulse current and to an ultrahigh-frequency field]
Hyperparathyroidism, Primary
The effect of primary hyperparathyroidism on pancreatic exocrine function.
Hyperpigmentation
Screening the dermatological potential of plectranthus species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase.
Hypersensitivity
Expression of IL-17A concentration and effector functions of peripheral blood neutrophils in food allergy hypersensitivity patients.
Heterogeneity in Pathogenicity-related Properties and Stress Tolerance in Aspergillus fumigatus Clinical Isolates.
In vitro and in vivo effects of Ranunculus peltatus subsp. baudotii methanol extract on models of eicosanoid production and contact dermatitis.
Platelet-activating factor- and leukotriene B4-induced release of lactoferrin from blood neutrophils of atopic and nonatopic individuals.
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: experimental studies in animals.
Release of lactoferrin and elastase in human allergic skin reactions.
[Clinical analysis of chronic pulmonary aspergillosis and discovery of a elastase inhibitor]
Hypertension
A small animal model for early cerebral aneurysm pathology.
Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.
Arterial hypertension and aneurysmal dilatation.
Cathepsin S promotes the development of pulmonary arterial hypertension.
Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-? in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
Effect of elastase in vitro on small mesenteric arteries of rats with experimental hypertension.
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.
Elastase-like enzyme in the aorta of spontaneously hypertensive rats.
Ellagic Acid Ameliorates Lung Inflammation and Heart Oxidative Stress in Elastase-Induced Emphysema Model in Rat.
Endogenous animal models of intracranial aneurysm development: a review.
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.
Human Mesenchymal Stem Cell-Derived Microvesicles Prevent the Rupture of Intracranial Aneurysm in Part by Suppression of Mast Cell Activation Via a PGE2-Dependent Mechanism.
Investigating the efficacy of a new intravenous (IV) nanoemulsified sevoflurane/arginine formulation for maintenance of general anesthesia for embolization of cerebral aneurysm.
Mast Cell Promotes the Development of Intracranial Aneurysm Rupture.
Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness.
Mesenchymal stem cells-derived exosomes modulate vascular endothelial injury via miR-144-5p/PTEN in intracranial aneurysm.
Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension.
Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy.
Noninvasive Vagus Nerve Stimulation Prevents Ruptures and Improves Outcomes in a Model of Intracranial Aneurysm in Mice.
Oral Presentations of the 2016 Annual Meeting of the Congress of Neurological Surgeons: San Diego, California: September 24-28, 2016: 100?Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
Plasma leukocyte elastase concentration in angiographically diagnosed coronary artery disease.
Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm.
Protective Effect of Mesenchymal Stem Cells Against the Development of Intracranial Aneurysm Rupture in Mice.
Protective effects of BP-1-102 against intracranial aneurysms-induced impairments in mice.
Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.
Roles of Nicotine in the Development of Intracranial Aneurysm Rupture.
Sequential activation of matrix metalloproteinase 9 and transforming growth factor beta in arterial elastocalcinosis.
Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms.
Stem cell-derived extracellular vesicles mitigate ageing-associated arterial stiffness and hypertension.
Study of cerebral aneurysms in a modified rat model: from real-time imaging to histological analysis.
Successful serial imaging of the mouse cerebral arteries using conventional 3-T magnetic resonance imaging.
[Activity of leukocyte elastase in coronary disease diagnosed by coronarography]
[History and Recent Development of Basic Research Using an Experimental Intracranial Aneurysm Model].
[The elastolytic effect of elastase in experimental hypertension in rats]
Hypertension, Pregnancy-Induced
Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy-induced hypertension.
Hypertension, Pulmonary
Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity.
Comparative effects of isosorbide dinitrate, prednisolone, indomethacin, and elastase on the development of monocrotaline-induced pulmonary hypertension.
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.
Elastase and cell matrix interactions in the pathobiology of vascular disease.
Elastase and the pathobiology of unexplained pulmonary hypertension.
Emerging therapies for the treatment of pulmonary hypertension.
Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension.
Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost.
Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension.
New developments in the pulmonary circulation in children.
Retinoic acid fails to reverse emphysema in adult mouse models.
SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats.
[Changes of neutrophil elastase in COPD and the role of elastase in experimental pulmonary hypertension]
[Effect of elastase inhibitor on pulmonary hypertension induced by monocrotaline]
[Monocrotaline-induced pulmonary hypertension in animals]
Hyperthyroidism
Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA.
Elastase inhibitory activity in serum of patients with thyroid dysfunction.
Plasma polymorphonuclear elastase in patients with hyperthyroidism.
Hypertrophy, Right Ventricular
The effect of oxygen on Cor pulmonale in experimental emphysema induced by elastase or elastase and beta-aminopropionitrile in hamsters.
Hyperventilation
Prophylactic effects of dexamethasone in lung injury caused by hyperoxia and hyperventilation.
Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury.
Hypotension
Acute phase response to nitroprusside-induced controlled hypotension in patients undergoing radical prostatectomy.
Idiopathic Interstitial Pneumonias
[Evaluation of the elastase burden in patients with idiopathic interstitial pneumonia]
Idiopathic Pulmonary Fibrosis
Detection of antibodies in serum of patients with idiopathic pulmonary fibrosis against isolated rat alveolar type II cells.
Elevated serum superoxide dismutase levels correlate with disease severity and neutrophil degranulation in idiopathic pulmonary fibrosis.
The role of neutrophil elastase in chronic inflammation.
Ileus
Assessment of systemic inflammation by time-trends of blood granulocyte count and plasma myeloperoxidase and elastase concentrations following colic surgery in horses.
Immune Complex Diseases
Elastase from polymorphonuclear leucocytes: a regulatory enzyme in immune complex disease.
Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease.
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: experimental studies in animals.
Immune System Diseases
Flavonoids as inhibitors of human neutrophil elastase.
Intravenous immunoglobulin replacement treatment reduces in vivo elastase secretion in patients with common variable immune disorders.
Infarction, Middle Cerebral Artery
Neutrophil elastase and neurovascular injury following focal stroke and reperfusion.
Infections
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
A food-responsive switch modulates TFEB and autophagy, and determines susceptibility to coxsackievirus infection and pancreatitis.
A genome-wide study of Pseudomonas aeruginosa outer membrane protein immunogenicity using self-assembling protein microarrays.
A point-of-care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation.
A porcine ligated loop model reveals new insight into the host immune response against Campylobacter jejuni.
A protein secreted in vivo by Echinococcus granulosus inhibits elastase activity and neutrophil chemotaxis.
A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.
Activation of human Hageman factor by Pseudomonas aeruginosa elastase in the presence or absence of negatively charged substance in vitro.
Adherence of Pseudomonas aeruginosa to respiratory epithelium and the effect of leucocyte elastase.
Age-dependent changes in protease and elastase production in cultures of Pseudomonas aeruginosa.
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
An experimental study on the effects of elastase, bleomycin and infection on the growth and tensile strength of elastic tissue in rabbit fetal membranes.
Assessment of elastase as a Pseudomonas aeruginosa virulence factor in experimental lung infection in mink.
Assessment of infection in chronic wounds based on the activities of elastase, lysozyme and myeloperoxidase.
Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity.
Beta-adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release.
Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.
Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis.
Capillary plasma neutrophil elastase alpha-1-proteinase inhibitor as infection parameter in neonates.
Cellular function of elastase in Pseudomonas aeruginosa: role in the cleavage of nucleoside diphosphate kinase and in alginate synthesis.
Changes in plasma elastase during pregnancy and sub partu.
Chemical inhibitors of the conserved bacterial transcriptional regulator DksA1 suppressed quorum sensing-mediated virulence of Pseudomonas aeruginosa.
Chlamydia trachomatis in andrologic patients--direct and indirect detection.
Circulating neutrophil elastase in infectious diseases in geriatric patients.
Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation.
Co-infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice.
Cold Plasma Inactivation of Bacterial Biofilms and Reduction of Quorum Sensing Regulated Virulence Factors.
Collagen binding, elastase production, and slime production associated with coagulase-negative staphylococci isolated from bovine intramammary infections.
Comparative molecular docking analysis of essential oil constituents as elastase inhibitors.
Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.
Contribution of toxin A and elastase to virulence of Pseudomonas aeruginosa in chronic lung infections of rats.
Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa.
Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome.
Degradation of basement membranes by Pseudomonas aeruginosa elastase.
Deletion of the PA4427-PA4431 Operon of Pseudomonas aeruginosa PAO1 Increased Antibiotics Resistance and Reduced Virulence and Pathogenicity by Affecting Quorum Sensing and Iron Uptake.
Detection of elastase from Pseudomonas aeruginosa in sputum and its potential role in epithelial cell permeability.
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Disseminated Aspergillosis Following Resolution of Pneumocystis Pneumonia with Sustained Elevation of Beta-Glucan in an Intensive Care Unit: a Case Report.
Early immune response to the components of the type III system of Pseudomonas aeruginosa in children with cystic fibrosis.
Effects of a caffeine-free Cola nitida nuts extract on elastase/alpha-1-proteinase inhibitor balance.
Effects of elastase, protease and common antigen (OEP) from Pseudomonas aeruginosa on protection against burns in mice.
Effects of immunization of horses with common antigen (OEP), protease toxoid, and elastase toxoid on corneal ulceration due to Pseudomonas aeruginosa infection.
Effects of Pseudomonas aeruginosa elastase on alveolar epithelial permeability in guinea pigs.
Elastase and cathepsin G activities are present in immature bone marrow neutrophils and absent in late marrow and circulating neutrophils of beige (Chediak-Higashi) mice.
Elastase as an indicator of silent genital tract infection in infertile men.
Elastase inhibitor for detection and treatment of inflammation and infection.
Elastase LasB of Pseudomonas aeruginosa promotes biofilm formation partly through rhamnolipid-mediated regulation.
Elastase-mediated membrane fusion of highly pathogenic porcine reproductive and respiratory syndrome virus at host cell surface.
Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A.
Elastase: a predictive marker of inflammation and/or infection.
Enzymatic activity of Microsporum canis and Trichophyton mentagrophytes from breeding rabbits with and without skin lesions.
Enzymatic inactivation of human plasma C1-inhibitor and alpha 1-antichymotrypsin by Pseudomonas aeruginosa proteinase and elastase.
Enzymuria in antibiotic therapy of acute infections.
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Evaluation of a stage-specific proteolytic enzyme of Schistosoma mansoni as a marker of exposure.
Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection.
Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: extracellular protease and elastase as in vivo virulence factors.
Experimental studies of the pathogenesis of infections owing to Pseudomonas aeruginosa: elastase, an IgG protease.
Expression of elastase on polymorphonuclear neutrophils in vitro and in vivo: identification of CD11b as ligand for the surface-bound elastase.
Fast solubilization of human lung elastin by Pseudomonas aeruginosa elastase.
Fluctuations in elastase of cervical mucus and clinical efficacy of cefodizime in obstetric and gynecologic infections.
Host and Pathogen Biomarkers for Severe Pseudomonas aeruginosa Infections.
House dust mite Der p 1 downregulates defenses of the lung by inactivating elastase inhibitors.
Human basement membrane antigens from lung, placenta and kidney.
Human Lysozyme Peptidase Resistance Is Perturbed by the Anionic Glycolipid Biosurfactant Rhamnolipid Produced by the Opportunistic Pathogen Pseudomonas aeruginosa.
IL-17 Plays a Role in RSV-induced Lung Inflammation and Emphysema in Elastase and LPS-injured Mice.
In vivo activity of proteases of Pseudomonas aeruginosa in a rat model.
In vivo bacterial protease production during Pseudomonas aeruginosa corneal infection.
In vivo characterization of host and bacterial protease expression during Pseudomonas aeruginosa corneal infections in naive and immunized mice.
Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase.
Increased elastase-alpha 1-antitrypsin complex in fulminant hepatic failure: relationship to bacterial infection and activation of coagulation.
Infection induces antibodies against the cercarial secretions, but not against the cercarial elastases of Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum and Trichobilharzia ocellata.
Inflammation and infection imaging with a 99mTc-neutrophil elastase inhibitor in monkeys.
Inflammatory markers in cystic fibrosis patients with lung Pseudomonas aeruginosa infection.
Inhibition of HIV-1 by modification of a host membrane protease.
Inhibition of Quorum Sensing-Controlled Virulence Factors and Biofilm Formation in Pseudomonas aeruginosa by Culture Extract from Novel Bacterial Species of Paenibacillus Using a Rat Model of Chronic Lung Infection.
Inhibition of quorum-sensing-dependent virulence factors and biofilm formation of clinical and environmental Pseudomonas aeruginosa strains by ZnO nanoparticles.
Interferon-gamma (IFN-gamma) treatment decreases the inflammatory response in chronic Pseudomonas aeruginosa pneumonia in rats.
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Intestinal permeability changes, systemic endotoxemia, inflammatory serum markers and sepsis after Whipple's operation for carcinoma of the pancreas head.
Iron facilitates the RetS-Gac-Rsm cascade to inversely regulate protease IV (piv) expression via the sigma factor PvdS in Pseudomonas aeruginosa.
JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.
Liver collagenase in murine schistosomiasis.
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Matrix metalloproteinases induction by pseudomonal virulence factors and inflammatory cytokines in vitro.
Multiple antibiotic resistance index, fitness and virulence potential in respiratory Pseudomonas aeruginosa from Jamaica.
Multiple virulence factors regulated by quorum sensing may help in establishment and colonisation of urinary tract by Pseudomonas aeruginosa during experimental urinary tract infection.
NETosis delays diabetic wound healing in mice and humans.
Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.
Neutrophil enzymes in urine for the detection of urethral infection in men.
Neutrophil Extracellular Traps Are Markers of Wound Healing Impairment in Patients with Diabetic Foot Ulcers Treated in a Multidisciplinary Setting.
Neutrophil Extracellular Traps in the Amniotic Cavity of Women with Intra-Amniotic Infection: A New Mechanism of Host Defense.
Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
Observations on Pseudomonas aeruginosa proteolytic and toxic activity in experimentally infected rats.
Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice.
Passive protection against Pseudomonas aeruginosa infection in an experimental leukopenic mouse model.
Pathogenesis of the mouse keratitis produced with Pseudomonas aeruginosa.
Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease.
Penicillin V acylases from gram-negative bacteria degrade N-acylhomoserine lactones and attenuate virulence in Pseudomonas aeruginosa.
Phenotypic and molecular characteristics of Aeromonas salmonicida subsp. salmonicida isolated in southern and northern Finland.
Phenotypic characterization of enzymatic activity of clinical dermatophyte isolates from animals with and without skin lesions and humans.
Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites.
Plasma and urine elastase alpha-1-proteinase inhibitor levels in neonatal urinary tract infection.
Plasma concentrations of granulocytic elastase-alpha 1-proteinase inhibitor complex in patients with severe head injury, multiple trauma or cerebral bleeding.
Plasma leucocyte elastase concentrations in smokers.
Polymorphonuclear elastase in neonatal sepsis.
Polymorphonuclear leukocyte function and serum opsonic activity in surgical patients.
Positive correlation of algD transcription to lasB and lasA transcription by populations of Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis.
Premature rupture of the membranes and amniotic infections--the significance of laboratory tests.
Prevalence of protease and elastase production by clinical isolates of Pseudomonas aeruginosa in relation to aeruginocine typing patterns.
Production of extracellular enzymes by Microsporum canis and their role in its virulence.
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
Protease inhibitors in bronchoalveolar lavage fluid from neonates with special reference to secretory leukocyte protease inhibitor.
Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection.
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Proteolytic activation of corneal matrix metalloproteinase by Pseudomonas aeruginosa elastase.
Pseudomonas aeruginosa elastase and its role in pseudomonas infections.
Pseudomonas aeruginosa Elastase Contributes to the Establishment of Chronic Lung Colonization and Modulates the Immune Response in a Murine Model.
Pseudomonas aeruginosa proteases and corneal virulence.
Quantifying the effect of trypsin and elastase on in vitro SARS-CoV infections.
Quorum sensing-dependent post-secretional activation of extracellular proteases in Pseudomonas aeruginosa.
Response of antimicrobial peptides from porcine neutrophils to pentoxifylline and antigens from Gram negative and Gram positive bacteria.
Role of elastase as a virulence factor in experimental Pseudomonas aeruginosa infection in mice.
Role of elastase in a mouse model of chronic respiratory Pseudomonas aeruginosa infection that mimics diffuse panbronchiolitis.
Role of exotoxin A and elastase in the pathogenicity of Pseudomonas aeruginosa strain PAO experimental mouse burn infection.
S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.
Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni.
Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein.
Selective inhibitors of human neutrophil proteinase 3.
Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers.
Serum derived protease inhibitors and leucocyte elastase in sputum and the effect of infection.
Specific inhibition of Pseudomonas aeruginosa elastase injected intracorneally in rabbit eyes.
Specific protease deficiency in polymorphonuclear leukocytes of Chédiak-Higashi syndrome and beige mice.
Study of biological characteristics of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis and from patients with extra-pulmonary infections.
Synergistic effect of immune gamma-globulin fraction on protection by antibiotic against corneal ulcers in experimental mice infected with Pseudomonas aeruginosa.
Targeting host cell proteases to prevent SARS-CoV-2 invasion.
The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10.
The effect of elastase-specific monoclonal and polyclonal antibodies on the virulence of Aspergillus fumigatus in immunocompromised mice.
The effects of Fasciola hepatica infection on the total antioxidant status (TAS) and the activity of proteases and their inhibitors in rat serum.
The electrophoretic mobility of alpha 1-antitrypsin in sputum and its relationship to protease inhibitory capacity, leucocyte elastase concentrations and acute respiratory infection.
The evaluation of markers of prostatic inflammation and function of the prostate gland in patients with chronic prostatitis.
The inactivation of antithrombin III by serum elastase in patients with surgical infections.
The Natural Polypeptides as Significant Elastase Inhibitors.
The possible role of granulocyte elastase in renal damage from acute pyelonephritis.
The rapid in vivo evolution of Pseudomonas aeruginosa in ventilator-associated pneumonia patients leads to attenuated virulence.
The role of elastase in the differentiation of Bacteroides nodosus infections in sheep and cattle.
The role of Pseudomonas aeruginosa elastase as a potent inflammatory factor in a rat air pouch inflammation model.
The role of the elastase of Pseudomonas aeruginosa in experimental infection.
The usefulness of elastase measurement in the sperm for the diagnosis of urogenital male inflammation and infection.
Therapeutic effect of immunization with OEP, protease toxoid and elastase toxoid on corneal ulcers in mice due to Pseudomonas aeruginosa infection.
Trichophyton tonsurans exocellular protease expression: correlation with clinical presentation in tinea capitis.
Vaccine efficacies of elastase, exotoxin A, and outer-membrane protein F in preventing chronic pulmonary infection by Pseudomonas aeruginosa in a rat model.
Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors.
Volatiles from Subtropical Convolvulaceae That Interfere with Bacterial Cell-to-Cell Communication as Potential Antipathogenic Drugs.
[Automatic detection and clinical application of semen biochemical markers].
[Clinical studies on imipenem/cilastatin sodium in the field of obstetrics and gynecology]
[Diagnostic value of granulocyte elastase determination in cord blood of newborn infants at risk for maternofetal infection]
[Elastase activity in bronchoalveolar lavage fluid from patients with chronic respiratory tract infections]
[Elastase of polymorphonuclear granulocytes. Determination in plasma in pregnancy and following premature rupture of the membranes]
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
[Immunologic monitoring of patients with cystic fibrosis: value of different laboratory findings]
[Importance of plasma PMN granulocyte elastase concentration determination in pregnant patients with premature rupture of fetal membranes]
[New aspects of the diagnosis of pancreatic cancer by determination of granulocyte elastase]
[Proteases, antiproteases and pulmonary emphysema]
[Pseudomonas aeruginosa elastase inhibits immune phagocytosis mediated by pulmonary surfactant protein A].
[Reliability of polymorphonuclear elastase for the diagnosis of neonatal sepsis]
[Significance of Pseudomonas aeruginosa virulence factors for acute and chronic Pseudomonas aeruginosa infections]
[Significance of Pseudomonas aeruginosa virulence factors in acute and chronic Pseudomonas aeruginosa infections]
[The role of the quorum sensing system in a rat model of Pseudomonas aeruginosa pulmonary infection and its relationship with the expression of virulence factors]
Infectious Bovine Rhinotracheitis
Increased elastase activity in nasal mucus associated with nasal colonization by Pasteurella haemolytica in infectious bovine rhinotracheitis virus-infected calves.
Infertility
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
Bacteriology of the cervix in cases of infertility: effect on human and animal spermatozoa and role of elastase.
Clinical relevance of polymorphonuclear (PMN-) elastase determination in semen and serum during infertility investigation.
Evaluation of granulocyte elastase as a seminal plasma marker for leukocytospermia.
Granulocyte elastase levels do not correlate with anaerobic and aerobic bacterial growth in seminal plasma from infertile men.
Resistin correlates with elastase and interleukin-6 in human seminal plasma.
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study.
Circulating human leucocyte elastase in patients with inflammatory bowel disease.
Detection of pro- and anti-inflammatory cytokines in stools of patients with inflammatory bowel disease.
Effect of intestinal inflammation on fecal elastase concentration in dogs.
Elastase as a potential biomarker for radiation-induced gut wall injury of the distal bowel in an experimental mouse model.
Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation.
Leucocyte elastase in chronic inflammatory bowel diseases: a marker of inflammatory activity?
Neutrophil-elastase in chronic inflammatory bowel disease: a marker of disease activity?
Respiratory burst of circulating polymorphonuclear leukocytes and plasma elastase levels in patients with inflammatory bowel disease in remission.
Influenza, Human
Cleavage of influenza A virus H1 hemagglutinin by swine respiratory bacterial proteases.
Critical Role of SerpinB1 in Regulating Inflammatory Responses in Pulmonary Influenza Infection.
Tailor-made cleavage site attenuates influenza B.
Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase.
Trypsin-resistant protease activation mutants of an influenza virus.
Insulin Resistance
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.
SerpinB1 Promotes Pancreatic ? Cell Proliferation.
Intermittent Claudication
Cross-linked fibrin degradation products, progression of peripheral arterial disease, and risk of coronary heart disease.
Intervertebral Disc Displacement
[Procalcitonin (PCT) as diagnostic tool for the monitoring of spondylodiscitis]
Intestinal Diseases
Circulating human leucocyte elastase in patients with inflammatory bowel disease.
Intracranial Aneurysm
A mouse model of intracranial aneurysm: technical considerations.
A novel murine elastase saccular aneurysm model for studying bone marrow progenitor-derived cell-mediated processes in aneurysm formation.
A small animal model for early cerebral aneurysm pathology.
Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.
Collagen cross-linkage, elastolytic and collagenolytic activities in cerebral aneurysms: a preliminary investigation.
Elastase-induced intracranial aneurysms in hypertensive mice.
Elastase-induced saccular aneurysms in rabbits: comparison of geometric features with those of human aneurysms.
Elastin degradation in the superficial temporal arteries of patients with intracranial aneurysms reflects changes in plasma elastase.
From bench to bedside: utility of the rabbit elastase aneurysm model in preclinical studies of intracranial aneurysm treatment.
Human Mesenchymal Stem Cell-Derived Microvesicles Prevent the Rupture of Intracranial Aneurysm in Part by Suppression of Mast Cell Activation Via a PGE2-Dependent Mechanism.
Investigating the efficacy of a new intravenous (IV) nanoemulsified sevoflurane/arginine formulation for maintenance of general anesthesia for embolization of cerebral aneurysm.
Mast Cell Promotes the Development of Intracranial Aneurysm Rupture.
Metalloproteases and intracranial vascular lesions.
Modified murine intracranial aneurysm model: aneurysm formation and rupture by elastase and hypertension.
Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in Microsomal Prostaglandin E2 Synthase Type 1-Deficient Mice: Attenuation by Aspirin.
Potential Influences of Gut Microbiota on the Formation of Intracranial Aneurysm.
Prevention Effect of Antiplatelets on Aneurysm Rupture in a Mouse Intracranial Aneurysm Model.
Protective Effect of Mesenchymal Stem Cells Against the Development of Intracranial Aneurysm Rupture in Mice.
Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing.
Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.
Roles of Nicotine in the Development of Intracranial Aneurysm Rupture.
Serum elastase and alpha-1-antitrypsin levels in patients with ruptured and unruptured cerebral aneurysms.
Sex and Genetic Background Effects on the Outcome of Experimental Intracranial Aneurysms.
[Aneurysmal model induced by elastase]
[Effects of elastase on experimentally induced aneurysms in rats]
Invasive Pulmonary Aspergillosis
Lack of vessel wall elastolysis in human invasive pulmonary aspergillosis.
Murine model of invasive pulmonary Aspergillosis: Follow-up of tissue injury, fungal burden and mortality with distinct elastase production strains.
The effect of elastase-specific monoclonal and polyclonal antibodies on the virulence of Aspergillus fumigatus in immunocompromised mice.
Ischemic Stroke
Do extracellular-matrix-regulating enzymes play a role in cervical artery dissection?
Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
Erythrocyte damage and leukocyte activation in ischemic stroke.
Strongly increased levels of fibrinogen elastase degradation products in patients with ischemic stroke.
Joint Diseases
Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases.
Influence of some natural and semisynthetic agents on elastase and cathepsin G from polymorphonuclear granulocytes.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Measurement of proteoglycans, elastase, collagenase and protein in synovial fluid in inflammatory and degenerative arthropathies.
Pathobiochemical significance of granulocyte elastase complexed with proteinase inhibitors: effect on glycosaminoglycan metabolism in cultured synovial cells.
The degradation of articular collagen by neutrophil proteinases.
[New clinico-chemical values in chronic joint diseases. Granulocyte elastase and UDP-D-xylose:proteoglycan core protein-beta-D-xylosyltransferase of chondrocytes]
[Proteolytic occurrences in the metabolism of cartilage and their modification by antirheumatics]
Keratitis
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
Contribution of proteases and LasR to the virulence of Pseudomonas aeruginosa during corneal infections.
Corneal virulence of Pseudomonas aeruginosa elastase B and alkaline protease produced by Pseudomonas putida.
Degradation of uniquely glycosylated secretory immunoglobulin a in tears from patients with Pseudomonas aeruginosa keratitis.
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Genetic features of Pseudomonas aeruginosa isolates associated with eye infections referred to Farabi Hospital, Tehran, Iran.
Inhibitory effects of ovomacroglobulin on bacterial keratitis in rabbits.
Pseudomonas aeruginosa elastase and its role in pseudomonas infections.
Pseudomonas keratitis. The role of an uncharacterized exoprotein, protease IV, in corneal virulence.
Relationship of Virulence Factors and Clinical Features in Keratitis Caused by Pseudomonas aeruginosa.
The role of Pseudomonas aeruginosa elastase in corneal ring abscess formation in pseudomonal keratitis.
Ketosis
[Activity of elastase and its inhibitors in tissues of aorta and blood serum in various types of acidosis]
Kidney Failure, Chronic
Effect of hemodialysis on acid leukocyte-type ribonuclease, alkaline ribonuclease and polymorphonuclear elastase serum levels in patients with end-stage renal disease.
Elastase, ?1-Proteinase Inhibitor, and Interleukin-8 in Children and Young Adults with End-Stage Kidney Disease Undergoing Continuous Ambulatory Peritoneal Dialysis.
Elastase, myeloperoxidase, nitric oxide metabolites and oxidative status in subjects with clinical stable chronic renal failure on conservative treatment.
Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients.
Latent Tuberculosis
Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.
Leg Ulcer
Differential proteinase expression by Pseudomonas aeruginosa derived from chronic leg ulcers.
Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration.
Expression of elastase and fibrin in venous leg ulcer biopsies: a pilot study of pentoxifylline versus placebo.
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
Proteolytic inactivation of transforming growth factor beta3 by elastase in venous leg ulcers: implications for clinical trials using topically-applied peptide growth factors.
Tenascin-C degradation in chronic wounds is dependent on serine proteinase activity.
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation.
Leiomyoma
Activities of proteinases and of a proteinase B inhibitor in tumors of the human uterus.
Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.
Leishmaniasis, Cutaneous
Leishmania amazonensis promastigotes induce and are killed by neutrophil extracellular traps.
Leprosy
Elastase activity in granulomatous inflammation in experimental murine leprosy.
Leukemia
Elastase activity in leukemic cells.
Elastase mediated fibrinolysis in acute promyelocytic leukemia.
Immunocytochemical identification of abnormal polymorphonuclear neutrophils in patients with leukemia.
Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice.
Plasma levels of human granulocytic elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in leukemia.
Promoter and enhancer elements from the rat elastase I gene function independently of each other and of heterologous enhancers.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
High PR3 or ELA2 expression by CD34+ cells in advanced-phase chronic myeloid leukemia is associated with improved outcome following allogeneic stem cell transplantation and may improve PR1 peptide-driven graft-versus-leukemia effects.
Leukemia, Myeloid
Lymphodepletion is permissive to the development of spontaneous T-cell responses to the self-antigen PR1 early after allogeneic stem cell transplantation and in patients with acute myeloid leukemia undergoing WT1 peptide vaccination following chemotherapy.
Preferential localisation of elastase in cytosol of human myeloid leukemia HL-60 cells.
Leukemia, Myeloid, Acute
Acute myeloid leukemia: immunohistologic findings in paraffin-embedded bone marrow biopsy specimens.
Combined procoagulant activity and proteolytic activity of acute promyelocytic leukemic cells: reversal of the bleeding disorder by cell differentiation.
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Elastase activity in leukemic cells.
Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice.
Structural and functional characterization of the human CD36 gene promoter: identification of a proximal PEBP2/CBF site.
The role of mitochondrial proteases in leukemic cells and leukemic stem cells.
Leukemia, Promyelocytic, Acute
Elastase mediated fibrinolysis in acute promyelocytic leukemia.
Leukemoid Reaction
The immunophenotypic profile of hepatic hemopoiesis in fetuses with Down's syndrome during the second trimester of development.
Leukocytosis
Absence of plasma protease-antiprotease imbalance in the formation of saccular cerebral aneurysms.
Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise.
Leukopenia
Adult respiratory distress-like syndrome during hemodialysis: relationship between activation of complement, leukopenia, and release of granulocyte elastase.
Aspects of biocompatibility of two different dialysis membranes: cuprophane and polysulfone.
Biocompatibility of a new polycarbonate dialysis membrane.
Clinical evaluation of a new high-flux cellulose acetate membrane.
Comparison of blood biocompatibility during haemodialysis with cuprophane and polyacrylonitrile membranes.
Release of granulocyte proteinases during hemodialysis.
Leukostasis
Continuous intravenous infusion of elastase in normal and agranulocytic minipigs--effects on the lungs and the blood coagulation system.
Experimental studies on the adult respiratory distress syndrome: effects of induced DIC; granulocytes and elastase in mini pigs.
Lipomatosis
The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.
Liver Cirrhosis
A case of ruptured hepatoma followed by elastase-induced disseminated intravascular coagulation.
Elastase secretion in pancreatic disease.
Studies on the inhibition of experimental liver fibrosis. 2. The mechanism of the inhibition of liver fibrosis of rats due to carbon tetrachloride by elastase.
Studies on the inhibition of liver fibrosis. Effect of elastase on the liver fibrosis of rats due to carbon tetrachloride [proceedings]
The significance of post-hepatectomy changes in polymorphonuclear elastase and endotoxin levels.
[Blood concentration of granulocytic elastase, surgical invasion and postoperative complications--with special reference to surgical resection of liver cirrhosis]
[Effect of FZHY recipe on elastase expression in liver fibrosis in rats]
Liver Cirrhosis, Biliary
Evidence of an increased nitric oxide production in primary biliary cirrhosis.
Liver Diseases
Anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver disease.
Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Liver Failure, Acute
Increased elastase-alpha 1-antitrypsin complex in fulminant hepatic failure: relationship to bacterial infection and activation of coagulation.
Liver Neoplasms
Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea.
Sideritis Perfoliata (Subsp. Perfoliata) Nutritive Value and Its Potential Medicinal Properties.
[Blood concentration of granulocytic elastase, surgical invasion and postoperative complications--with special reference to surgical resection of liver cirrhosis]
Lung Diseases
alpha 1-Proteinase inhibitor, elastase activity, and lung disease severity in cystic fibrosis.
Alpha-1-antitrypsin and alpha-1-antitrypsin-neutrophil elastase complex in bronchoalveolar lavage fluid of patients with pulmonary diseases (pilot study).
An alpha1-antitrypsin enhancer polymorphism is a genetic modifier of pulmonary outcome in cystic fibrosis.
Antileukoprotease is associated with elastin fibers in the extracellular matrix of the human lung. An immunoelectron microscopic study.
Chromatographic studies of human lung elastin digestion products obtained by leucocyte elastase: comparison between newborn and adult soluble fragments.
Comparison of urinary desmosine excretion in patients with chronic obstructive pulmonary disease or cystic fibrosis.
COPD and endobronchial polyposis associated with hypogammaglobulinemia. Are proteolytic enzymes involved?
Effects of dexamethasone and indomethacin on elastase, alpha 1-proteinase inhibitor, and fibronectin in bronchoalveolar lavage fluid from neonates.
Effects of plasma, tumour necrosis factor, endotoxin and dexamethasone on extracellular proteolysis by neutrophils from healthy subjects and patients with emphysema.
Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
Elastase mediates the release of growth factors from lung in vivo.
Elastase secretion by stimulated macrophages. Characterization and regulation.
Elevation of plasma truncated elastase alpha 1-proteinase inhibitor complexes in patients with inflammatory lung diseases.
Hydrolytic enzymes of alveolar macrophages.
Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease.
Inhibition of airway proteases in cystic fibrosis lung disease.
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Interleukin-8 and neutrophils in systemic sclerosis with lung involvement.
Limited proteolysis of surfactant protein D causes a loss of its calcium-dependent lectin functions.
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance.
Neutrophil elastase treated dendritic cells promote the generation of CD4(+)FOXP3(+) regulatory T cells in vitro.
Neutrophil oxidants inactivate alpha-1-protease inhibitor and promote PMN-mediated detachment of cultured endothelium. Protection by free methionine.
Neutrophilic inflammation as a major determinant in the progression of cystic fibrosis.
Neutrophils from F508del cystic fibrosis patients produce IL-17A and express IL-23 - dependent IL-17RC.
Oxygen exposure in the newborn guinea pig lung lavage cell populations, chemotactic and elastase response: a possible relationship to neonatal bronchopulmonary dysplasia.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.
Potential role of recombinant secretory leucoprotease inhibitor in the prevention of neutrophil mediated matrix degradation.
Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases.
Role of human neutrophil peptides in lung inflammation associated with alpha1-antitrypsin deficiency.
Serum studies of leucocyte elastase in acute and chronic lung diseases.
The fibrinogen cleavage product A{alpha}-Val360, a specific marker of neutrophil elastase activity in vivo.
The role of matrix metalloproteases in cystic fibrosis lung disease.
The use of elastase in the treatment of chronic suppurative pulmonary diseases.
Total Synthesis of the Potent Marine-Derived Elastase Inhibitor Lyngbyastatin 7 and in Vitro Biological Evaluation in Model Systems for Pulmonary Diseases.
[Blood elastase in tuberculosis and other lung diseases]
[Effect of elastase and its inhibitors on the mechanism of development of various pulmonary diseases]
[Protease activity and the level of antibodies to connective tissue elements in various lung diseases]
[The damaging effect of activated human neutrophils on isolated perfused rat lungs--the role of elastase]
Lung Diseases, Interstitial
[Determination of elastase and alpha 2-macroglobulin in bronchoalveolar lavage fluid in patients with interstitial diseases and its clinical significance]
Lung Diseases, Obstructive
Natural history of abdominal aortic aneurysm with and without coexisting chronic obstructive pulmonary disease.
[Elastase, elastase inhibitors and chronic obstructive lung diseases]
[Natural history of abdominal aortic aneurysm with and without concomitant chronic obstructive pulmonary disease]
Lung Injury
Activation of polymorphonuclear leukocytes in oleic acid-induced lung injury.
Administration of alpha 1-proteinase inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Bacterial species-dependent inhibition of human granulocyte elastase.
Changes in tissue fibronectin in elastase induced lung injury.
Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice.
Coumarinic derivatives show anti-inflammatory effects on alveolar macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo.
Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.
Effect of plant Kunitz inhibitors from Bauhinia bauhinioides and Bauhinia rufa on pulmonary edema caused by activated neutrophils.
Elastase inhibition reduced death associated with acid aspiration-induced lung injury in hamsters.
Endotoxin, septic shock and acute lung injury: neutrophils, macrophages and inflammatory mediators.
Evaluation of the urinary desmosine radioimmunoassay as a monitor of lung injury after endobronchial elastase instillation in sheep.
G-CSF mediates lung injury in mice with adenine-induced acute kidney injury.
Inhibitors of elastase in airway lavage samples from ventilated preterm human neonates.
N-acetylcysteine pretreatment of cardiac surgery patients influences plasma neutrophil elastase and neutrophil influx in bronchoalveolar lavage fluid.
Natural inhibitors of neutrophil function in acute respiratory distress syndrome.
Neutral endopeptidase determines the severity of pancreatitis-associated lung injury.
Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: evaluation of interstitial protease activity by in situ zymography.
ONO-5046, an elastase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits.
Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome.
Pharmacological blockade of the MaxiK channel attenuates experimental acute pancreatitis and associated lung injury in rats.
Potency of truncated secretory leukoprotease inhibitor assessed in acute lung injury models in hamsters.
Preventive and therapeutic effect of anti-IL-17 in an experimental model of elastase-induced lung injury in C57Bl6 mice.
Proteases and lung injury.
Recombinant Human Elafin Promotes Alveologenesis in Newborn Mice Exposed to Chronic Hyperoxia.
Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury.
Relative contribution of three main virulence factors in Pseudomonas aeruginosa pneumonia.
Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury.
The influence of aminophylline on human neutrophils--possible protection of lung from proteolytic injury.
[Cell population and elastase activity in bronchoalveolar lavage fluid from rats exposed to high concentration of nitrogen dioxide]
[Infections of the respiratory tract with Pseudomonas aeruginosa in cystic fibrosis]
Lung Neoplasms
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer.
Fibrinogen split products, antiproteases and granulocytic elastase in patients with lung cancer.
Local increase of antiprotease and neutrophil elastase-alpha 1-proteinase inhibitor complexes in lung cancer.
Measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy with granulocyte colony-stimulating factor.
Polymorphisms in the promoter region of the neutrophil elastase gene are associated with lung cancer development.
Serial measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy.
Serum levels of alpha1-antitrypsin and alpha2-macroglobulin in lung cancer.
Tutuilamides A-C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties.
[Cathepsin B activity and concentration of elastase and alpha-1 proteinase inhibitor complex in non-small-cell lung cancer: 2 year follow-up study]
Lupus Erythematosus, Systemic
Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.
Elastase activity in serum and synovial fluid of patients with connective tissue disorders.
Higher elastase activity associated with lower IL-18 in GCF from juvenile systemic lupus patients.
Lymphedema
Local inhibition of elastase reduces EMILIN1 cleavage reactivating lymphatic vessel function in a mouse lymphedema model.
Lymphoma
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
Lymphoma, Non-Hodgkin
Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases.
Malabsorption Syndromes
[New fecal markers: recent developments and perspectives]
Malaria
Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria.
Stronger host response per parasitized erythrocyte in Plasmodium vivax or ovale than in Plasmodium falciparum malaria.
Malaria, Falciparum
Polymorphonuclear leucocyte elastase in Plasmodium falciparum malaria.
Malnutrition
Evaluation of malnutrition with blood ghrelin and fecal elastase levels in acute decompensated heart failure patients.
Exocrine pancreatic function is preserved in systemic sclerosis.
Marfan Syndrome
Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome.
Mastitis
Crosstalk between coagulation and inflammation in mastitis and metritis in dairy cows.
Inflammatory effect of cleaved bovine lactoferrin by elastase on staphylococcal mastitis.
Peptidomic analysis of healthy and subclinically mastitic bovine milk.
Single intramammary infusion of recombinant bovine interleukin-8 at dry-off induces the prolonged secretion of leukocyte elastase, inflammatory lactoferrin-derived peptides, and interleukin-8 in dairy cows.
Melanoma
Dermatological applications of the flavonoid phloretin.
In vitro and in silico studies of two 1,4-naphthoquinones and their topical formulation in bigels.
Leukocyte activation by isolated hyperthermic liver and limb perfusion due to malignancy.
Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber.
Thymocid®, a Standardized Black Cumin (Nigella sativa) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells.
Melanosis
Antioxidant and anti-aging carbon quantum dots using tannic acid.
Melioidosis
Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.
Meningitis
Elastase and granzymes during meningococcal disease in children: correlation to disease severity.
Elastase given intracisternally opens blood-brain barrier in newborn piglets.
Proteinase-antiproteinase imbalance in meningitis: determination of alpha 1 proteinase inhibitor (alpha 1PI), elastase-alpha 1PI complex, and elastase inhibition capacity in cerebrospinal fluid.
Meningitis, Bacterial
Proteinase-antiproteinase imbalance in meningitis: determination of alpha 1 proteinase inhibitor (alpha 1PI), elastase-alpha 1PI complex, and elastase inhibition capacity in cerebrospinal fluid.
[Hearing disorders in children less than 16 months of age after bacterial meningitis with reference to cerebrospinal fluid elastase]
Meningococcal Infections
Elastase and granzymes during meningococcal disease in children: correlation to disease severity.
Microaneurysm
Experience with Microaneurysm Formation at the Basilar Terminus in the Rabbit Elastase Aneurysm Model.
Insulin-like growth factor-1 retinal microangiopathy in the pig eye.
Migraine Disorders
Serum elastase activity is elevated in migraine.
Mitral Valve Prolapse
Clinical and diagnostic significance of measurement of blood activity of endopeptidases and their inhibitors in youths with mitral valve prolapse.
Mucinoses
[Elastase and its inhibitors in the pathogenesis of benign ovarian tumors]
Mucocutaneous Lymph Node Syndrome
Increased serum granulocyte colony-stimulating factor correlates with coronary artery dilatation in Kawasaki disease.
Ulinastatin, an elastase inhibitor, inhibits the increased mRNA expression of prostaglandin H2 synthase-type 2 in Kawasaki disease.
Mucopolysaccharidosis I
Upregulation of elastase activity in aorta in mucopolysaccharidosis I and VII dogs may be due to increased cytokine expression.
Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice.
Mycoses
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.
Inactivation of ?1-proteinase inhibitor by Candida albicans aspartic proteases favors the epithelial and endothelial cell colonization in the presence of neutrophil extracellular traps.
Myelodysplastic Syndromes
Decline in antibiotic enzyme activity of neutrophils is a prognostic factor for infections in patients with myelodysplastic syndrome.
myeloperoxidase deficiency
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Myocardial Infarction
Elastase in young subjects with acute myocardial infarction: Evaluation at the initial stage and after 12 months.
Elastase-type enzymes and their relation to blood lipids in atherosclerotic patients.
Fibrin (ogen)-derived peptide B beta 30-43 is a sensitive marker of activated neutrophils during fibrinolytic-treated acute myocardial infarction in man.
Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart.
Inhibition of human neutrophils NEP activity, CD11b/CD18 expression and elastase release by 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde, oleacein.
Neutrophil function in ischemic heart disease.
Persistence of high plasma elastase level in young subjects with acute myocardial infarction.
Relationship between elastase and total antioxidant status in young subjects with recent myocardial infarction.
SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury.
[Activity of blood serum elastase in patients with acute myocardial infarct in the pre-hospital period]
[Serum elastinolytic activity and blood lipids in various clinical forms of arteriosclerosis and in acute myocardial infarct]
Myocardial Ischemia
Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study.
Elastase release following myocardial ischemia during extracorporeal circulation (ECC) -- marker of ongoing systemic inflammation?
Neutrophil function in ischemic heart disease.
Myocardial Stunning
Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart.
Postischemic infusion of sivelestat sodium hydrate, a selective neutrophil elastase inhibitor, protects against myocardial stunning in swine.
Myocarditis
A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis.
Nasal Polyps
The activation and function of IL-36? in neutrophilic inflammation in chronic rhinosinusitis.
Neonatal Sepsis
Capillary plasma elastase alpha 1-proteinase inhibitor in infected and non-infected neonates.
Polymorphonuclear elastase in neonatal sepsis.
[Reliability of polymorphonuclear elastase for the diagnosis of neonatal sepsis]
Neoplasm Metastasis
Antiproliferative activity of Lavatera cashmeriana- protease inhibitors towards human cancer cells.
Elastase activity enhances the adhesion of neutrophil and cancer cells to vascular endothelial cells.
Limited proteolysis of angiogenin by elastase is regulated by plasminogen.
The elastase-mediated pathway of fibrinolysis.
[Elastase activity during growth and metastasis of tumors andthe pharmacological effects in C57Bl/6 mice]
Neoplasms
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
3,4,5-Trihydroxycinnamic acid exerts a protective effect on pulmonary inflammation in an experimental animal model of COPD.
A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: its application to the measurement of granulocyte-derived elastase digests in plasma.
A novel soft tissue model for biomaterial-associated infection and inflammation - bacteriological, morphological and molecular observations.
A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.
Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents.
Activation of Focal Adhesion Kinase in Detached Human Epidermal Cancer Cells and Their Long-term Survival Might be Associated with Cell Surface Expression of Laminin-5.
Activities of proteinases and of a proteinase B inhibitor in tumors of the human uterus.
Activity of lysosomal and nonlysosomal proteases and contents of protein and its degradation products in the blood serum of rats with fibrosarcoma induced by methylcholanthrene.
Adenosine A2A receptor agonists as anti-inflammatory agents.
Age dependent variation of elastin and elastase in aorta and human breast cancers.
Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice.
An Anti-Inflammatory 2,4-Cyclized-3,4-Secospongian Diterpenoid and Furanoterpene-Related Metabolites of a Marine Sponge Spongia sp. from the Red Sea.
An In Vitro Hemodynamic Loop Model to Investigate the Hemocytocompatibility and Host Cell Activation of Vascular Medical Devices.
Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis.
Anti-inflammatory activity of clarithromycin in adults with chronically inflamed sinus mucosa.
Anti-inflammatory effects of troxerutin are mediated through elastase inhibition.
Anti-L-selectin antibody therapy does not worsen the postseptic course in a baboon model.
Antimetastatic activity of boro-amino acid analog protease inhibitors against B16BL6 melanoma in vivo.
Antiproliferative activity of Lavatera cashmeriana- protease inhibitors towards human cancer cells.
Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents.
Aprotinin reduces cardiac troponin I release and inhibits apoptosis of polymorphonuclear cells during off-pump coronary artery bypass surgery.
Association between inflammatory mediators and the fibrinolysis system in infectious pleural effusions.
Association between injury pattern of patients with multiple injuries and circulating levels of soluble tumor necrosis factor receptors, interleukin-6 and interleukin-10, and polymorphonuclear neutrophil elastase.
Beneficial effect of 20?hydroxyecdysone exerted by modulating antioxidants and inflammatory cytokine levels in collagen?induced arthritis: A model for rheumatoid arthritis.
Bioactive Capnosanes and Cembranes from the Soft Coral Klyxum flaccidum.
Biochemical markers as a predictor for lymph-node involvement in patients with cervical-cancer of the uterus.
Biocompatibility of a cuprophane charcoal-based detoxification device in cirrhotic patients with hepatic encephalopathy.
Biomimetic Liposome with Surface-Bound Elastase for Enhanced Tumor Penetration and Chemo-Immumotherapy.
Biosynthesis and distribution of leucocyte elastase inhibitor. Production of recombinant inhibitor.
Blood activation during neonatal extracorporeal life support.
Briarenones A?C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum.
Cardiopulmonary bypass exacerbates oxidative stress but does not increase proinflammatory cytokine release in patients with diabetes compared with patients without diabetes: regulatory effects of exogenous nitric oxide.
Carijoside A, a bioactive sterol glycoside from an octocoral Carijoa sp. (Clavulariidae).
Cell associated elastase activities of rat mammary tumour cells.
Cembranoid-Related Metabolites and Biological Activities from the Soft Coral Sinularia flexibilis.
Chemoattractant-induced release of elastase by tumor necrosis factor-primed human neutrophils: auto-regulation by endogenous adenosine.
Chondroitin-4-sulphate reduced oxidative injury in caerulein-induced pancreatitis in mice: the involvement of NF-kappaB translocation and apoptosis activation.
Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp.
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Collagenase and elastase production by mouse mammary adenocarcinoma primary cultures and cloned cells.
Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate.
Comparison of lung protective ventilation strategies in a rabbit model of acute lung injury.
Correlation between increased granulocyte elastase release and activation of blood coagulation in patients with lung cancer.
Cyclin E and its low molecular weight forms in human cancer and as targets for cancer therapy.
Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration.
Cytokine, elastase and oxygen radical release by Fusobacterium nucleatum-activated leukocytes: a possible pathogenic factor in periodontitis.
Cytokines and acute phase reactants during flare-up of contact allergy to gold.
Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity.
Cytoplasmic Cyclin E Expression Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer.
Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.
Detection of undegraded fibrin and tumor necrosis factor-alpha in venous leg ulcers.
Determination of disulfide bond patterns in laminin beta1 chain N-terminal domains by nano-high-performance liquid chromatography/matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry.
Development of endotoxin tolerance in humans in vivo.
Different enzyme classes associated with human natural killer cells may mediate disparate functions.
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective.
Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.
Discovery of stage-related proteins in esophageal squamous cell carcinoma using proteomic analysis.
Dissection of laminin by cathepsin G into its long-arm and short-arm structures and localization of regions involved in calcium dependent stabilization and self-association.
Echinoclerodane A: A New Bioactive Clerodane-Type Diterpenoid from a Gorgonian Coral Echinomuricea sp.
Echinohalimane A, a bioactive halimane-type diterpenoid from a Formosan gorgonian Echinomuricea sp. (Plexauridae).
Effect of elastase in reversing the de-differentiation of rabbit costal chondrocytes in culture induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).
Effect of the Neutrophil Elastase Inhibitor Sivelestat on Perioperative Inflammatory Response After Pediatric Heart Surgery with Cardiopulmonary Bypass: A Prospective Randomized Study.
Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.
Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro.
Effects of propofol and desflurane anaesthesia on the alveolar inflammatory response to one-lung ventilation.
Effects of tumor necrosis factor on PMN chemotaxis, chemiluminescence, and elastase activity.
Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.
Elastase activities of human bladder cancer cell lines derived from high grade invasive tumours.
Elastase activity enhances the adhesion of neutrophil and cancer cells to vascular endothelial cells.
Elastase activity in capillary and aortic endothelial cells.
Elastase expression by infiltrating neutrophils in gliomas.
Elastase released from human granulocytes stimulated with N-formyl-chemotactic peptide prevents activation of tumor cell prourokinase (pro-uPA).
Elastase--does this enzyme play any role in bladder cancer invasion?
Elastases in human breast carcinoma cell lines.
Ellagitannins modulate the inflammatory response of human neutrophils ex vivo.
Endostatin expression in pancreatic tissue is modulated by elastase.
Endothelial apoptosis is induced by serum of patients after cardiopulmonary bypass.
Endotoxin-inducible granulocyte-mediated hepatocytotoxicity requires adhesion and serine protease release.
Enzymatic degradation of tumor necrosis factor by activated human neutrophils: role of elastase.
Enzyme-activatable imaging probe reveals enhanced neutrophil elastase activity in tumors following photodynamic therapy.
Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase.
Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression.
Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells.
Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors.
Exocrine function following the whipple operation as assessed by stool elastase.
Expression of elastase and fibrin in venous leg ulcer biopsies: a pilot study of pentoxifylline versus placebo.
Extracellular proteolysis of fibronectin by neutrophils: characterization and the effects of recombinant cytokines.
First efficacy and safety results with the antibody containing leukocyte inhibition module in cardiac surgery patients with neutrophil hyperactivity.
Flavonoids as inhibitors of human neutrophil elastase.
Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.
Genomic analysis of the prognostic effect of tumor-associated neutrophil-related genes across 15 solid cancer types: an immune perspective.
Glucocorticoid attenuates a decrease of antithrombin III following major surgery.
Granulocyte functions and changes in ability with age in newborns; Report no. 2: Activation of granulocyte functions by cytokines.
Granulomatous reaction and tissue remodelling in the cutaneous lesion of chromomycosis.
Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass.
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
Human colon carcinoma cells synthesize and secrete alpha 1-proteinase inhibitor.
Human endothelial cells regulate polymorphonuclear leukocyte degranulation.
Human tumor cell urokinase-type plasminogen activator (uPA): degradation of the proenzyme form (pro-uPA) by granulocyte elastase prevents subsequent activation by plasmin.
Hyaluronan reduces colitis-induced intraperitoneal inflammation during peritoneal dialysis.
Hyperplasia and tumors of the islets of Langerhans in mice bearing an elastase I-SV40 T-antigen fusion gene.
Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration.
Immunohistological diagnosis of "plasmacytoid T cell lymphoma" in paraffin wax sections.
Improvement of nutrient absorption may enhance systemic oxidative stress in cystic fibrosis patients.
Inactivation of human tumor cell pro-urokinase by granulocyte elastase.
Increased elastase release by CF neutrophils is mediated by tumor necrosis factor-alpha and interleukin-8.
Increased monocyte transcription of the proteinase 3 gene in small vessel vasculitis.
Inflammatory mediators in autotransfusion drain blood after knee arthroplasty, with and without leucocyte reduction.
Inflammatory response in peritoneal exudate and plasma of patients undergoing planned relaparotomy for severe secondary peritonitis.
Influence of fixation and decalcification on the immunohistochemical staining of cell-specific markers in paraffin-embedded human bone biopsies.
Infusion of hypertonic saline (7.5% NaCl) causes minor immunological changes in normovolaemic women.
Ingenuity pathway analysis of human facet joint tissues: Insight into facet joint osteoarthritis.
Inhibition of the pro-inflammatory mediators in rat neutrophils by shanzhiside methyl ester and its acetyl derivative isolated from Barleria prionitis.
Inhibitory effect of serine protease inhibitors on neutrophil-mediated endothelial cell injury.
Inhibitory effect of streptozotocin on tumor development in transgenic mice bearing an elastase I-SV40 T-antigen fusion gene.
Interleukin-8 and polymorphoneutrophil leucocyte activation in hemolytic uremic syndrome of childhood.
Isolation and partial characterization of a proteinase inhibitor from human colorectal adenocarcinoma.
Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea.
Krempfielins Q and R, two new eunicellin-based diterpenoids from the soft coral Cladiella krempfi.
Leukocyte activation by isolated hyperthermic liver and limb perfusion due to malignancy.
Lobocrassins A-E: new cembrane-type diterpenoids from the soft coral Lobophytum crassum.
Localization of elastase and tumor necrosis factor alpha mRNA by non-radioactive in situ hybridization in cultures of alveolar macrophages.
Luminally expressed gastrointestinal biomarkers.
Measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy with granulocyte colony-stimulating factor.
Mediators and cytokines in allergic and viral-triggered rhinitis.
Microbial alginate dressings show improved binding capacity for pathophysiological factors in chronic wounds compared to commercial alginate dressings of marine origin.
MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3.
Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer.
Mitochondrial dysfunctions in myalgic encephalomyelitis/chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways.
Mitogenic stimulation of human lymphocytes mediated by a cell surface elastase.
Myocardial revascularization by left ventricular assisted beating heart is associated with reduced systemic inflammatory response.
Neutrophil activation by anti-proteinase 3 antibodies in Wegener's granulomatosis: role of exogenous arachidonic acid and leukotriene B4 generation.
Neutrophil number and interleukin-8 and elastase concentrations in bronchoalveolar lavage fluid correlate with decreased arterial oxygenation after cardiopulmonary bypass.
Neutrophils develop rapid proinflammatory response after engulfing Hb-activated platelets under intravascular hemolysis.
Normothermia has beneficial effects in cardiopulmonary bypass attenuating inflammatory reactions.
Overexpression of Cyclin E and its Low Molecular Weight Isoforms Cooperate with Loss of p53 in Promoting Oncogenic Properties of MCF-7 Breast Cancer Cells.
Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-Kappa B.
Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice.
Phosphorylcholine or heparin coating for pediatric extracorporeal circulation causes similar biologic effects in neonates and infants.
Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula.
Plasma tumour necrosis factor alpha in cystic fibrosis.
Platelet-activating factor produced by endothelial cells. A molecule with autocrine and paracrine properties.
Polymorphonuclear elastase in human colorectal carcinoma.
Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors.
Pretreatment with ibuprofen augments circulating tumor necrosis factor-alpha, interleukin-6, and elastase during acute endotoxinemia.
Protease inhibitor activity in human skeletal muscle.
Proteinases in catabolism and malnutrition.
Recent results in animal models of pancreatic carcinoma: histogenesis of tumors.
Release of mediators of systemic inflammatory response syndrome in the course of a severe delayed hemolytic transfusion reaction caused by anti-D.
Release of membrane-associated mucins from ocular surface epithelia.
Release of proinflammatory cytokines during pediatric cardiopulmonary bypass: heparin-bonded versus nonbonded oxygenators.
Retinoic acid fails to reverse emphysema in adult mouse models.
Review of pancreatic cancer.
Role of lung contusions on posttraumatic inflammatory response and organ dysfunction in traumatized patients.
Rosuvastatin Alters the Proteome of High Density Lipoproteins: Generation of alpha-1-antitrypsin Enriched Particles with Anti-inflammatory Properties.
Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).
Salivary interleukin-1beta concentration and the presence of multiple pathogens in periodontitis.
Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma.
Sequential Treatments with Tongsai and Bufei Yishen Granules Reduce Inflammation and Improve Pulmonary Function in Acute Exacerbation-Risk Window of Chronic Obstructive Pulmonary Disease in Rats.
Serglycin--structure and biology.
Serial measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy.
Serine protease-induced enhancement of blood-borne metastasis of rat ascites tumour cells and its prevention with deoxyribonuclease.
Serum alpha-1 proteinase inhibitor in advanced cancer: mass variants and functionally inert forms.
Serum elastase I levels in pancreatic disease.
Serum human pancreatic elastase I levels in pancreatic disease.
Serum immunoreactive elastase in diagnosis of pancreatic diseases. A sensitive marker for pancreatic cancer.
Significance of tissue laminin P(1) elastase and fibronectin levels in transitional cell carcinoma of the bladder.
Size-fractionated heparins have differential effects on human neutrophil function in vitro.
Snail1 is required for the maintenance of the pancreatic acinar phenotype.
Sputum elastase in steady-state bronchiectasis.
Stronger host response per parasitized erythrocyte in Plasmodium vivax or ovale than in Plasmodium falciparum malaria.
Study of the systemic and pulmonary oxidative stress status during exposure to propofol and sevoflurane anaesthesia during thoracic surgery.
Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant.
Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils.
Synergistic neutrophil elastase-cytokine interaction degrades collagen in three-dimensional culture.
Systemic inflammatory response syndrome after cardiac operations.
Systemic leukocyte filtration during cardiopulmonary bypass.
Tangeretin Inhibits Oxidative Stress and Inflammation via Upregulating Nrf-2 Signaling Pathway in Collagen-Induced Arthritic Rats.
Target protein interactions of indole-3-carbinol and the highly potent derivative 1-Benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.
Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis.
Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase.
The alpha 3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes.
The De Barsy syndrome.
The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.
The elastase-mediated pathway of fibrinolysis.
The possibility of diagnosing small pancreatic cancer (less than 4.0 cm) by measuring various serum tumor markers. A retrospective study.
The presence of tumour-infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell carcinoma.
The pulmonary immune effects of mechanical ventilation in patients undergoing thoracic surgery.
The release of interleukin-8 during intravenous bolus treatment with interleukin-2.
The role of leucocyte elastase in malignant tumors of the head and neck.
Tissue and plasma elastase and anti-protease (alpha 1 protease inhibitor-alpha 2 macroglobulin) levels in malignancies of head and neck.
Tissue plasminogen activator in murine exocrine pancreas cancer: selective expression in ductal tumors and contribution to cancer progression.
Treatment with dimethyl fumarate reduces the formation and rupture of intracranial aneurysms: Role of Nrf2 activation.
Tumor necrosis factor stimulates human neutrophils to release leukotriene B4 and platelet-activating factor. Induction of phospholipase A2 and acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase activity and inhibition by antiproteinase.
Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice.
Tumor-specific proteolytic processing of cyclin E generates hyperactive lower-molecular-weight forms.
Two-dimensional electrophoresis of proteins in tumours of the lung.
Ulinastatin - a newer potential therapeutic option for multiple organ dysfunction syndrome.
Vasculitic complications associated with coccidioidal meningitis.
Ventricular assist device in severe heart failure: effects on cytokines, complement and body weight.
Zisheng Shenqi Decoction Ameliorates Monosodium Urate-Mediated Gouty Arthritis in Rats via Promotion of Autophagy through the AMPK/mTOR Signaling Pathway.
[Assay of serum elastase 1 in adenocarcinoma of the pancreas: diagnostic value, compared and combined study with serum CEA and CA 19-9]
[Changes of plasma nitric oxide and tumor necrosis factor-alpha in lung elastase injury induced inflammatory response of hamster]
[Clinical studies on nine cases with miliary tuberculosis: serum level of tumor markers and bronchoscopy in differential diagnosis]
[Clinical utility of ulinastatin, urinary protease inhibitor in acute Kawasaki disease]
[Clinico-enzymologic parallels in patients of reproductive age with benign epithelial ovarian tumors]
[Detection of various component in the trace sample of gingival crevicular fluid]
[Determination of the pancreatic inflammatory process activity in chronic pancreatitis].
[Elastase activity during growth and metastasis of tumors andthe pharmacological effects in C57Bl/6 mice]
[Elastase and its inhibitors in the pathogenesis of benign ovarian tumors]
[Host factors in cancer chemotherapy]
[Inflammatory response mediators in newborns and infants with congenital heart diseases during surgical treatment under extracorporeal circulation]
[New aspects of the diagnosis of pancreatic cancer by determination of granulocyte elastase]
[Reactions of derivatives of beta-lactam antibiotics with non-antibacterial biological activity]
[Responses of cytokines, acute phase proteins, and polymorphonuclear cell elastase to surgical stress in the patients with esophageal cancer]
[Successful Surgical Resection of Expansive-Growth Acinar Cell Carcinoma-A Case Report].
[Systemic inflammation in patients with chronic obstructive pulmonary disease and obesity].
Nephritis
Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats.
Relative roles of elastase and reactive oxygen species in the degradation of human glomerular basement membrane by intact human neutrophils.
[The effect of elastase on Masugi nephritis in rats]
Nephrosis
[The effect of the elastase on aminonucleoside nephrosis]
Nephrotic Syndrome
Low molecular weight heparin may benefit nephrotic remission in steroid?sensitive nephrotic syndrome via inhibiting elastase.
Plasma proteinase inhibitor activity and hemostasis tests in children with nephrotic syndrome. Effect of prednisone alone and prednisone plus epsilon-aminocaproic acid treatment regimens: a preliminary report.
Neuralgia
Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA.
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
Neurogenic Inflammation
Pain and sickle cell disease.
Neutropenia
Elastase inhibitors as potential therapies for ELANE-associated neutropenia.
Low levels of serum elastase are not associated with mutations in ELA-2 elastase encoding gene in chronic idiopathic neutropenia.
Mutant elastase in pathogenesis of cyclic and severe congenital neutropenia.
Neutrophil elastase converts human immature dendritic cells into transforming growth factor-beta1-secreting cells and reduces allostimulatory ability.
Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesis.
Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism.
Recurrent bacterial infections, but not fungal infections, characterise patients with ELANE-related neutropenia: a French Severe Chronic Neutropenia Registry study.
Severe congenital neutropenia: new lane for ELANE.
[Cyclic neutropenia. Detection of a mutation in the gene for neutrophil elastase (ELA2)]
Obesity
Exercise training attenuates neutrophil infiltration and elastase expression in adipose tissue of high-fat-diet-induced obese mice.
Obstetric Labor, Premature
Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions.
Investigation of midtrimester amniotic fluid factors as potential predictors of term and preterm deliveries.
Periodontal disease and spontaneous preterm birth: a case control study.
Polymorphonuclear elastase and interleukin-6 in amniotic fluid in preterm labor.
Onchocerciasis
Neutrophil activation in ivermectin-treated onchocerciasis patients.
oryzin deficiency
Cytochemical determination of granulocyte elastase and chymotrypsin in human myeloid cells and its application in acquired deficiency states and diagnosis of myeloid leukemia.
Elastase deficiency phenotype of Pseudomonas aeruginosa canine otitis externa isolates.
Lack of pancreatic body and tail in HNF1B mutation carriers.
Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction.
Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.
Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3.
Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase.
Pseudomonas aeruginosa from canine otitis externa exhibit a quorum sensing deficiency.
Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young.
Specific protease deficiency in polymorphonuclear leukocytes of Chédiak-Higashi syndrome and beige mice.
Osteoarthritis
Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix.
Elastase activity in cartilage extracts and synovial fluids from subjects with osteoarthritis or rheumatoid arthritis: the prominent role of metalloproteinases.
Granulocyte elastase as a new biochemical marker in the diagnosis of chronic joint diseases.
Impaired glutathione reductase activity and levels of collagenase and elastase in synovial fluid in rheumatoid arthritis.
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Measurement of proteoglycans, elastase, collagenase and protein in synovial fluid in inflammatory and degenerative arthropathies.
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Osteophyte
Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.
Osteoporosis
[Establishment of a novel mouse mode of elastase-induced chronic obstructive pulmonary disease related osteoporosis].
Otitis
Pseudomonas aeruginosa from canine otitis externa exhibit a quorum sensing deficiency.
Otitis Externa
Elastase deficiency phenotype of Pseudomonas aeruginosa canine otitis externa isolates.
Otitis Media
Eosinophil-derived neurotoxin, elastase, and cytokine profile in effusion from eosinophilic otitis media.
Out-of-Hospital Cardiac Arrest
Increased neutrophil elastase release in patients with cardiopulmonary arrest: role of elastase inhibitor.
Pancreatic Cyst
The role of the carboxyl ester lipase (CEL) gene in pancreatic disease.
Pancreatic Diseases
Diagnosis of chronic pancreatitis: Functional testing.
Elastase secretion in pancreatic disease.
Elastase-1 vs trypsin, lipase and amylase serum levels in pancreatic diseases.
Pancreatic elastase activation as a possible indicator of the relative hazard of different cigarettes.
Serum elastase I levels in pancreatic disease.
Serum immunoreactive elastase in diagnosis of pancreatic diseases. A sensitive marker for pancreatic cancer.
Serum levels of six pancreatic enzymes as related to the degree of renal dysfunction.
Serum protease inhibitor capacity for elastase and the severity of pancreatitis.
[Specificity of serum elastase level in pancreatic diseases]
[Studies on elastase in pancreatic diseases (author's transl)]
Pancreatic Fistula
Central Pancreatectomy Versus Distal Pancreatectomy and Pancreaticoduodenectomy for Benign and Low-Grade Malignant Neoplasms: A Retrospective and Propensity Score-Matched Study with Long-Term Functional Outcomes and Pancreas Volumetry.
Pancreatic Neoplasms
A High Omega-3 Fatty Acid Diet Mitigates Murine Pancreatic Precancer Development.
Characterization of the elastase 1-simian virus 40 T-antigen mouse model of pancreatic carcinoma: effects of sex and diet.
Elastase secretion in pancreatic disease.
Endostatin expression in pancreatic tissue is modulated by elastase.
Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors.
Exocrine function following the whipple operation as assessed by stool elastase.
Fecal Elastase Fails to Detect Steatorrhea in Patients With Locally Advanced Pancreatic Cancer.
Formation of the tetraploid intermediate is associated with the development of cells with more than four centrioles in the elastase-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer.
Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells.
Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice.
Prospective trial for early detection of pancreatic cancer by elevated serum immunoreactive elastase.
Role of serum pancreatic enzyme assays in diagnosis of pancreatic disease.
Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.
Sensitive serum markers for detecting pancreatic cancer.
Serum elastase I levels in pancreatic disease.
Serum immunoreactive elastase in diagnosis of pancreatic diseases. A sensitive marker for pancreatic cancer.
Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis.
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
The possibility of diagnosing small pancreatic cancer (less than 4.0 cm) by measuring various serum tumor markers. A retrospective study.
[Early detection of pancreatic cancer by serum markers]
Pancreatitis
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
Accuracy of plasma levels of polymorphonuclear elastase as early prognostic marker of acute pancreatitis in routine clinical conditions.
Acute pancreatitis induces FasL gene expression and apoptosis in the liver.
Amelioration of rat cerulein pancreatitis by guamerin-derived peptide, a novel elastase inhibitor.
Blood concentrations of polymorphonuclear leucocyte elastase and interleukin-6 are indicators for the occurrence of multiple organ failures at the early stage of acute pancreatitis.
Clinical usefulness of polymorphonuclear elastase in predicting the severity of acute pancreatitis: results of a multicentre study.
Clinical value of an automated granulocyte elastase assay in predicting severity of acute pancreatitis.
Comparing acid steatocrit and faecal elastase estimations for use in M-ANNHEIM staging for pancreatitis.
Comparison of elastase-1 with amylase, lipase, and trypsin-like immunoreactivity in the diagnosis of acute pancreatitis.
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Degradation and inactivation of plasma tumor necrosis factor-alpha by pancreatic proteases in experimental acute pancreatitis.
Determination of elastase-1 serum levels in post ERCP/EST pancreatic damage.
Diagnostic value of serum elastase 1 in pancreatic disease.
Dynamic aspects of granulocyte activation in rat severe acute pancreatitis.
Effect of a specific synthetic inhibitor of neutrophil elastase (ONO-5046) on the course of acute hemorrhagic pancreatitis in dogs.
Effect of new oligopeptide inhibitors of elastase on acute experimental pancreatitis in the rat.
Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.
Effect of plasma exchange on acute pancreatitis.
Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
Elastase activity and histological changes in lungs and in pancreas due to experimental pancreatitis.
Elastase levels during bile-induced pancreatitis in dogs determined by radioimmunoassay.
Elastic tissue injury in human acute pancreatitis.
Glucagon treatment of experimental acute pancreatitis.
Granulocyte elastase in assessment of severity of acute pancreatitis. Comparison with acute-phase proteins C-reactive protein, alpha 1-antitrypsin, and protease inhibitor alpha 2-macroglobulin.
Haemorrhagic pancreatitis induced by elastase.
Human cationic, pancreatic elastase in acute pancreatitis.
Indirect strong inhibition by acid-stable trypsin-plasmin inhibitor (ASTPI) of the activations of elastase and plasma fibrinolysis in a dog model of acute pancreatitis.
Inhibition of human pancreatic proteinases by human plasma alpha2-antiplasmin and antithrombin.
Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-reflow in ischemia/reperfusion-induced acute pancreatitis.
Is pancreatic exocrine insufficiency in celiac disease related to structural alterations in pancreatic parenchyma?
Management of severe acute pancreatitis.
Monitoring of serum proteinase--antiproteinase balance and systemic inflammatory response in prognostic evaluation of acute pancreatitis. Results of a prospective multicenter study.
Neutral endopeptidase determines the severity of pancreatitis-associated lung injury.
Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
Oxidative stress as an early prognostic factor in acute pancreatitis (AP): its correlation with serum phospholipase A2 (PLA2) and plasma polymorphonuclear elastase (PMN-E) in different-severity forms of human AP.
Pancreas transcription factor 1alpha expression is regulated in pancreatitis.
Pancreatic cationic elastase in porcine experimental pancreatitis.
Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome.
Pancreatic proteases in serum induce leukocyte-endothelial adhesion and pancreatic microcirculatory failure.
Pharmacological blockade of the MaxiK channel attenuates experimental acute pancreatitis and associated lung injury in rats.
Plasma levels of elastase, trypsin and their inhibitors in bile induced pancreatitis in the dog.
Polyclonal pancreatic elastase assay is superior to monoclonal assay for diagnosis of acute pancreatitis.
Pulmonary vascular injury in pancreatitis: evidence for a major role played by pancreatic elastase.
Radioimmunoreactive serum elastase levels and histologic changes during experimental pancreatitis in rats.
Serum elastase I levels in pancreatic disease.
Serum elastase in the diagnosis of acute pancreatitis: a prospective study.
Serum human pancreatic elastase I levels in pancreatic disease.
Serum immunoreactive elastase in diagnosis of pancreatic diseases. A sensitive marker for pancreatic cancer.
Serum protease inhibitor capacity for elastase and the severity of pancreatitis.
Specific interaction of pancreatic elastase and leucocytes to produce oxygen radicals and its implication in pancreatitis.
Studies on porcine pancreatic elastase activity. II. Immunoreactive elastase level during acute hemorrhagic pancreatitis in pigs.
Studies on serum immunoreactive elastase in experimental pancreatic rats. II. In chronic pancreatitis.
Studies on serum immunoreactive elastase in experimental pancreatitis rats. I. In acute pancreatitis.
The effect of ERCP on circulating pancreatic enzymes and pancreatic protease inhibitors.
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats.
The effects upon blood coagulation in dogs of experimentally induced pancreatitis and the infusion of pancreatic juice.
The management of bleeding from a pancreatic pseudocyst: a case report.
The measurement of serum immunoreactive pancreatic secretory trypsin inhibitor in gastrointestinal cancer and pancreatic disease.
The role of elastase in acute pancreatitis. I. Intrapancreatic elastolytic activity in bile-induced acute pancreatitis in dogs.
The role of elastase in acute pancreatitis. II. Intrapancreatic elastolytic activity in trypsin-induced acute pancreatitis in dogs.
The value of serum amylase and elastase measurements in the prediction of post-ERCP acute pancreatitis.
[Antienzyme function of the lungs in acute pancreatitis]
[Clinical usefulness of the determination of the lipase/elastase ratio and of the polymorphonuclear elastase in the hospital admission of the patient with acute pancreatitis]
[Clinical value of determination of the blood elastase activity as a marker of postoperative pancreatitis]
[Disseminated intravenous coagulation in acute necrotizing pancreatitis]
[Elastase activity in experimental pancreatitis]
[Experimental acute pancreatitis in rats and its histopathologic evolution in time. II. Acute pancreatitis induced with different enzymes: trypsin, alphachymotrypsin, elastase, collagenase and lipase]
[Histological structure of the pancreas in acute experimental pancreatitis by elastase]
[Morphologic aspects of experimental pancreatitis, caused by intracanalar injection of elastase]
[Role of free radicals on canine bile-induced pancreatitis and effect of superoxide dismutase]
[Studies on elastase. Part II. Immunoreactive elastase level during acute hemorrhagic pancreatitis in pigs (author's transl)]
[The activity of rat pancreas elastase and pro-elastase in experimental pancreatitis]
[The clinical utility of the quotient of lipase-amylase and polymorphonuclear elastase in acute pancreatitis]
[The effect of new oligopeptide elastase inhibitors in acute experimental pancreatitis in the rat]
[The value of estimation of serum pancreatic elastase in experimental pancreatic disorders in rats]
Pancreatitis, Acute Hemorrhagic
Studies on porcine pancreatic elastase activity. II. Immunoreactive elastase level during acute hemorrhagic pancreatitis in pigs.
The measurement of serum immunoreactive pancreatic secretory trypsin inhibitor in gastrointestinal cancer and pancreatic disease.
[Effect of elastase inhibitors on the course of hemorrhagic pancreatitis]
[Studies on elastase. Part II. Immunoreactive elastase level during acute hemorrhagic pancreatitis in pigs (author's transl)]
Pancreatitis, Acute Necrotizing
Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum.
Pancreatitis, Chronic
Chronic pancreatitis.
Clinical evaluation of the faecal elastase test in the diagnosis and staging of chronic pancreatitis.
Clinical value of a new fecal elastase test for detection of chronic pancreatitis.
Comparison of Endoscopic Retrograde Cholangiopancreatography, Endoscopic Ultrasonography, and Fecal Elastase 1 in Chronic Pancreatitis and Clinical Correlation.
Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-Mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues.
Diagnostic value of serum elastase 1 in pancreatic disease.
Elastase as a potential biomarker for radiation-induced gut wall injury of the distal bowel in an experimental mouse model.
Elastase secretion in pancreatic disease.
Fecal Elastase Levels Predict Honeycombing in Pancreas Detected with Endoscopic Ultrasound.
Fecal elastase test: evaluation of a new noninvasive pancreatic function test.
Is pancreatic exocrine insufficiency in celiac disease related to structural alterations in pancreatic parenchyma?
Method Performance of Bicarbonate and Electrolytes by Use of Duodenal Fluid for Assessment of Exocrine Pancreatic Function.
Modern diagnostics of chronic pancreatitis.
Overexpression of interleukin-1beta in the murine pancreas results in chronic pancreatitis.
Pancreas transcription factor 1alpha expression is regulated in pancreatitis.
Pancreatic Exocrine Function Is Preserved After Distal Pancreatectomy.
Response to "Diagnosis of exocrine pancreatic insufficiency in chronic pancreatitis: (13)C-mixed Triglyceride Breath Test versus Fecal Elastase: Methodological issues".
Role of Exocrine and Endocrine Insufficiency in the Management of Patients with Chronic Pancreatitis.
Serum human pancreatic elastase I levels in pancreatic disease.
Serum immunoreactive elastase in diagnosis of pancreatic diseases. A sensitive marker for pancreatic cancer.
Serum proteolytic and antiproteolytic activity in acute pancreatitis.
Studies on serum immunoreactive elastase in experimental pancreatic rats. II. In chronic pancreatitis.
The effect of primary hyperparathyroidism on pancreatic exocrine function.
Value of combinations of pancreatic function tests to predict mild or moderate chronic pancreatitis.
[Assay of serum elastase 1 in adenocarcinoma of the pancreas: diagnostic value, compared and combined study with serum CEA and CA 19-9]
[Behavior of elastase, antielastase and the enzymatic 5th fraction in patients with chronic pancreatitis]
[Change in proteolytic enzymatic activity in the blood serum in children with chronic diseases of the digestive organs]
[Clinical features of different variants of excretory pancreatic insufficiency]
[Diagnostic value of fecal elastase test in pancreatic exocrine deficiency]
[Effect of pancreatic substitutes on fecal and serum elastase and on pain in patients with chronic pancreatitis]
[Elastase inhibitor in the serum during acute and chronic pancreatitis]
[Faecal elastase I--its use in diagnosis of chronic pancreatitis]
[Methabolism of connective tissue in patients, suffering chronic pancreatitis].
Paralysis
[Characterization of proteo-, chitino- and lipolytic enzymes of parasitic fungus Conidiobolus coronatus]
Parasitemia
Elevated thrombomodulin plasma levels as a result of endothelial involvement in plasmodium falciparum malaria.
Stronger host response per parasitized erythrocyte in Plasmodium vivax or ovale than in Plasmodium falciparum malaria.
Pelvic Infection
Fluctuations in elastase of cervical mucus and clinical efficacy of cefodizime in obstetric and gynecologic infections.
Pemphigoid, Bullous
Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid.
Granulocyte-derived elastase and gelatinase B are required for dermal-epidermal separation induced by autoantibodies from patients with epidermolysis bullosa acquisita and bullous pemphigoid.
Respective contribution of neutrophil elastase and matrix metalloproteinase 9 in the degradation of BP180 (type XVII collagen) in human bullous pemphigoid.
Peri-Implantitis
aMMP-8 Point-of-Care/Chairside Oral Fluid Technology as a Rapid, Non-Invasive Tool for Periodontitis and Peri-Implantitis Screening in a Medical Care Setting.
Elastase, alpha2-macroglobulin and alkaline phosphatase in crevicular fluid from implants with and without periimplantitis.
Periodontal Attachment Loss
A 2-year longitudinal study of elastase in human gingival crevicular fluid and periodontal attachment loss.
Host enzymes in gingival crevicular fluid as diagnostic indicators of periodontitis.
Periodontal Diseases
Association models for periodontal disease progression: a comparison of methods for clustered binary data.
Elastase as an indicator of periodontal disease progression.
Elastase in gingival crevicular fluid from smokers and non-smokers with chronic inflammatory periodontal disease.
Local and systemic factors in periodontal disease increase matrix-degrading enzyme activities in rat gingiva: effect of micocycline therapy.
Measurement of both native and inactivated forms of alpha1 proteinase inhibitor in human inflammatory extracellular fluids.
Neutrophil elastase activity, levels of prostaglandin E2, and matrix metalloproteinase-8 in refractory periodontitis sites in smokers and non-smokers.
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease.
Salivary proteolytic activities in periodontitis, gingivitis and diabetes mellitus.
Stimulation of enzyme and cytokine production by methyl mercaptan in human gingival fibroblast and monocyte cell cultures.
[Effect of electrogingivectomy and elastase inhibitor on the enzymatic activity of the gingiva during the treatment of parodontosis]
[Effect of therapeutic parodontal dressing, containing an elastase inhibitor, on the state of periodontal tissues and the enzyme activity of mixed saliva in patients with parodontosis]
[Inhibition of elastase activity in human gingival extracts by elastin peptides]
[Proteases and their inhibitors in rapidly progressive and in juvenile periodontitis]
[The detection and clinical significance of three enzymes in gingival crevicular fluid]
Periodontal Pocket
Effect of cigarette smoking on oral elastase activity in adult periodontitis patients.
Oral fluid elastase as an indicator of periodontal health.
[Elastase estimation in human periodontal pocket exudate and its importance as an inflammation parameter]
Periodontitis
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
Aberrant neutrophil reactions in periodontitis.
Active and alpha-1 proteinase inhibitor complexed leukocyte elastase levels in crevicular fluid from patients with periodontal diseases.
Activity and inhibition of elastase in GCF.
Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis.
Altered relation between granulocyte elastase and alpha-2-macroglobulin in gingival crevicular fluid from sites with periodontal destruction.
Association of crevicular fluid elastase-like activity with histologically-confirmed attachment loss in ligature-induced periodontitis in beagle dogs.
Cigarette smoking induced liver insult concomitant with inflammatory mediators in serum crevicular fluid and bronchio alveolar lavage of schistosomal diabetic subjects with history of bronchial asthma.
Crevicular fluid elastase levels in relation to periodontitis and metabolic control of diabetes.
Cytokine, elastase and oxygen radical release by Fusobacterium nucleatum-activated leukocytes: a possible pathogenic factor in periodontitis.
Effect of cigarette smoking on oral elastase activity in adult periodontitis patients.
Effects of Geum urbanum L. root extracts and its constituents on polymorphonuclear leucocytes functions. Significance in periodontal diseases.
Elastase and lactoferrin in gingival crevicular fluid: possible indicators of a granulocyte-associated specific host response.
Elastase and metalloproteinase-9 concentrations in saliva in patients with chronic periodontitis.
Elastase as an indicator of periodontal disease progression.
Elastase release from gingival crevicular and peripheral neutrophils in periodontitis and health.
Expression of intracellular elastase activity in peripheral neutrophils from patients with adult periodontitis.
Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis.
Granulocyte elastase, matrix metalloproteinase-8 and prostaglandin E2 in gingival crevicular fluid in matched clinical sites in smokers and non-smokers with persistent periodontitis.
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Immunologic and microbiologic profiles of chronic and aggressive periodontitis subjects.
In vitro release of elastase from human blood and gingival crevicular neutrophils.
Increased release of free oxygen radicals from peripheral neutrophils in adult periodontitis after Fc delta-receptor stimulation.
Inhibition of crevicular fluid neutrophil elastase by alpha 1-antitrypsin in periodontal health and disease.
Longitudinal evaluation of elastase as a marker for the progression of periodontitis.
Oral fluid elastase as an indicator of periodontal health.
Periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid.
Proteolytic enzymes as indicators of periodontal health in gingival crevicular fluid of patients with Sjögren's syndrome.
Proteomics - The research frontier in periodontics.
Risk factors for periodontitis in HIV patients.
Salivary interleukin-1beta concentration and the presence of multiple pathogens in periodontitis.
Salivary proteolytic activities in periodontitis, gingivitis and diabetes mellitus.
The effects of non-surgical periodontal therapy on neutrophil elastase and elastase alpha-1 proteinase inhibitor levels in GCF in periodontitis patients with or without acute coronary syndrome.
The relationship between elastase and lactoferrin in healthy, gingivitis and periodontitis sites.
The Short-Term Effectiveness of Non-Surgical Treatment in Reducing Levels of Interleukin-1? and Proteases in Gingival Crevicular Fluid From Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis.
The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis.
Variations in crevicular fluid elastase levels in periodontitis patients on long-term maintenance.
[Functional activity of neutrophils and elastase inhibitory activity of blood serum and periodontal tissues during lymphotropic therapy of rapidly-progressing periodontitis]
[The effects of smoking on gingival crevicular fluid volume and elastase before and after initial periodontal treatment]
[The elastase activity in gingival crevicular fluid from rapidly progressive periodontitis]
Peripheral Arterial Disease
Cross-linked fibrin degradation products, progression of peripheral arterial disease, and risk of coronary heart disease.
Peritonitis
Anti-inflammatory effect of sulodexide during acute peritonitis in rats.
Collagenase and elastase released during peritonitis are complexed by plasma protease inhibitors.
Genotypic and phenotypic properties of coagulase-negative staphylococci causing dialysis catheter-related sepsis.
Hyaluronan modifies inflammatory response and peritoneal permeability during peritonitis in rats.
Intra-peritoneal free elastase in CAPD peritonitis.
Intraperitoneal interleukin-8 and neutrophil influx in the initial phase of a CAPD peritonitis.
Monitoring of the inflammatory response in early peritonitis.
N-Acetylglucosamine Reduces Inflammatory Response during Acute Peritonitis in Uremic Rats.
Role of alpha 1-proteinase inhibitor in restraining peritoneal inflammation in CAPD patients.
The extracellular release of granulocyte collagenase and elastase during phagocytosis and inflammatory processes.
[Diagnostic significance of some indices of systemic inflammation in peritonitis]
[The effect of leukocyte elastase on high molecular weight kininogen from human plasma in the presence of alpha-1 protease inhibitor. Analysis of proteolytic degradation]
Persistent Infection
Potential of preventing Pseudomonas aeruginosa lung infections in cystic fibrosis patients: experimental studies in animals.
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.
[An alpha 1-antitrypsin aerosol in the treatment of cystic fibrosis]
Pituitary Neoplasms
Structural similarities in the plasma membrane 3,3',5-triiodo-L-thyronine receptors from human, rat and mouse cultured cells. Analysis by affinity labeling.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
plasmin deficiency
Polymorphonuclear elastase in patients with homozygous type I plasminogen deficiency and ligneous conjunctivitis.
Pleural Effusion
Accuracy of chest sonography and polymorphonuclear elastase in the assessment of bacterial pleural effusion.
Diagnostic accuracy of pleural fluid polymorphonuclear elastase in the differentiation between pyogenic bacterial infectious and non-infectious pleural effusions.
Neutrophil elastase alpha 1-proteinase inhibitor complexes in pleural effusions.
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
Polymorphonuclear elastase in the early diagnosis of complicated pyogenic pleural effusions.
Pleurisy
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
Pneumoconiosis
Basic mechanisms leading to focal emphysema in coal workers' pneumoconiosis.
[Evaluation of matrix metaloproteinases (pro-mMP-1, MMP-2,8) and their inhibitor (TIMP-1) contents in patients with occupational lung diseases]
[Impaired balance of the lung proteolytic system in patients with pneumoconiosis and chronic dust-induced bronchitis]
Pneumonia
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
Acute lung inflammation: neutrophil elastase versus neutrophils in the bronchoalveolar lavage--neutrophil elastase reflects better inflammatory intensity.
Barotrauma susceptibility in hamster lungs following elastase exposure.
Characterization of protein-antiproteinase imbalance in bronchoalveolar lavage from patients with pneumonia.
Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin.
Co-infection of respiratory bacterium with severe acute respiratory syndrome coronavirus induces an exacerbated pneumonia in mice.
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Community-acquired pneumonia: evidence of functional inactivation of alpha 1 proteinase inhibitor.
Comparison of the effects of a multi-component vaccine and a formalin-killed cell vaccine on protection against enzootic of hemorrhagic pneumonia due to Pseudomonas aeruginosa in mink.
Compartmentalized IL-8 and elastase release within the human lung in unilateral pneumonia.
Competition between elastase and related proteases from human neutrophil for binding to alpha1-protease inhibitor.
Coumarinic derivatives show anti-inflammatory effects on alveolar macrophages, but their anti-elastase activity is essential to reduce lung inflammation in vivo.
Effect of the elastase inhibitor, eglin-c, on antibacterial mechanisms in experimental pneumonia. Description of a system to quantitate phagocytic and bactericidal activity of resident murine alveolar macrophages in vivo.
Effectiveness of immunization with multicomponent vaccines in protection against hemorrhagic pneumonia due to Pseudomonas aeruginosa infection in mink.
Effectiveness of immunization with single and multi-component vaccines prepared from a common antigen (OEP), protease and elastase toxoids of Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink due to P. aeruginosa.
Effects of dexamethasone and indomethacin on elastase, alpha 1-proteinase inhibitor, and fibronectin in bronchoalveolar lavage fluid from neonates.
Effects of inhaled beclomethasone compared to systemic dexamethasone on lung inflammation in preterm infants at risk of chronic lung disease.
Effects of the common protective antigen (OEP) and toxoids of protease and elastase from Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink.
Elastase Activity From Pseudomonas aeruginosa Respiratory Isolates and ICU Mortality.
Elastin and collagen degradation products in urine of patients with cystic fibrosis.
Elimination of p19ARF -expressing cells protects against pulmonary emphysema in mice.
Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection.
Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM.
Gallic acid ameliorates COPD-associated exacerbation in mice.
Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema.
IL-17 Plays a Role in RSV-induced Lung Inflammation and Emphysema in Elastase and LPS-injured Mice.
Inhalable, bioresponsive microparticles for targeted drug delivery in the lungs.
Intrapulmonary protein leakage in immunocompromised children and adults with pneumonia.
Local impairment of anti-neutrophil elastase capacity in community-acquired pneumonia.
Measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy with granulocyte colony-stimulating factor.
Modulation of elastase binding to elastin by human alveolar macrophage-derived lipids.
Molecular elucidation of pancreatic elastase inhibition by baicalein.
Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance.
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.
Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites.
Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.
Protease inhibitors in bronchoalveolar lavage fluid from neonates with special reference to secretory leukocyte protease inhibitor.
Protection against hemorrhagic pneumonia of mink by Pseudomonas aeruginosa multicomponent vaccine.
Proteinase inhibitory function in inflammatory lung disease. I. Acute bacterial pneumonia.
Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.
Pseudomonas aeruginosa elastase and its role in pseudomonas infections.
Regulation of adenovirus-mediated elafin transgene expression by bacterial lipopolysaccharide.
Relative contribution of three main virulence factors in Pseudomonas aeruginosa pneumonia.
Risk assessment of infected children with Pseudomonas aeruginosa pneumonia by combining host and pathogen predictors.
Risk factors for the degradation of lung elastic fibers in the ventilated neonate. Implications for impaired lung development in bronchopulmonary dysplasia.
Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema.
X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice.
[Evaluation of the elastase: alpha 1-antitrypsin balance in patients with bacterial pneumonia using bronchoalveolar lavage]
[Myeloperoxidase, lactoferrin and elastase in bronchoalveolar lavage and plasma in pneumonia]
[Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]
[Proteinase-inhibitors and renin in the pathogenesis of vascular insufficiency in acute pneumonia]
[Proteolytic activities in bronchoalveolar lavage fluid in pneumonia and chronic bronchitis]
[Serum elastase, proelastase and free hydroxyproline in acute pneumonia]
Pneumonia, Bacterial
[Evaluation of the elastase: alpha 1-antitrypsin balance in patients with bacterial pneumonia using bronchoalveolar lavage]
Pneumonia, Pneumococcal
Inhibitors of human neutrophil elastase in extracts of Streptococcus pneumoniae.
In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia.
The Role of Neutrophils and Neutrophil Elastase in Pneumococcal Pneumonia.
Pneumonia, Pneumocystis
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
[A case of acute progressive pulmonary cystic disease associated with Pneumocystis carinii pneumonia in a non-HIV-infected patient]
[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]
Pneumonia, Ventilator-Associated
Quorum-sensing activity and related virulence factor expression in clinically pathogenic isolates of Pseudomonas aeruginosa.
Polyarteritis Nodosa
Human neutrophil elastase: degradation of basement membrane components and immunolocalization in the tissue.
[Antineutrophil cytoplasmic antibodies--ANCA]
Pre-Eclampsia
Analysis of plasma elastase levels in early and late onset preeclampsia.
Correlated plasma elastase and sera cytotoxicity in eclampsia. A possible role of endothelin-1 induced neutrophil activation in preeclampsia-eclampsia.
Correlation of Plasma Neutrophil Elastase Activity and Endogenous Protease Inhibitor Levels with the Severity of Pre-eclampsia.
Endothelin, elastase, and endothelial dysfunction in pre-eclampsia.
Etiology and pathophysiology of preeclampsia.
Hypertensive disease in pregnancy.
Leukocyte activation and circulating leukocyte-derived microparticles in preeclampsia.
Microparticle subpopulations are increased in preeclampsia: possible involvement in vascular dysfunction?
Neutrophil activation and C-reactive protein concentration in preeclampsia.
Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.
The neutrophil and preeclampsia.
Thrombomodulin release from umbilical endothelial cells initiated by preeclampsia plasma-induced neutrophil activation.
Premature Birth
Depletion of polymorphonuclear leukocytes has no effect on preterm delivery in a mouse model of Escherichia coli-induced labor.
Periodontal disease and spontaneous preterm birth: a case control study.
Pressure Ulcer
Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF.
Involvement of proteolytic enzymes--plasminogen activators and matrix metalloproteinases--in the pathophysiology of pressure ulcers.
Prospective and randomised evaluation of the protease-modulating effect of oxidised regenerated cellulose/collagen matrix treatment in pressure sore ulcers.
Prion Diseases
Processing of whole femoral head allografts: a method for improving clinical efficacy and safety.
Prostatic Neoplasms
Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.
Prostatitis
Chronic prostatitis/chronic pelvic pain pyndrome): seminal markers of inflammation.
Proteinuria
Detection of mRNA for alpha-3 chain of type IV collagen in the glomerular epithelium, and the effect of perfused elastase on its expression.
Elastase deposits in the kidney and urinary elastase excretion in patients with glomerulonephritis - evidence for neutrophil involvement in renal injury.
Elastase, but not proteinase 3 (PR3), induces proteinuria associated with loss of glomerular basement membrane heparan sulphate after in vivo renal perfusion in rats.
Etiology of increased enzymuria in different morphological forms of glomerulonephritis.
The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo.
Pseudomonas Infections
Effects of immunization of horses with common antigen (OEP), protease toxoid, and elastase toxoid on corneal ulceration due to Pseudomonas aeruginosa infection.
Neutrophil inflammation and activation in bronchiectasis: comparison with pneumonia and idiopathic pulmonary fibrosis.
Passive protection against Pseudomonas aeruginosa infection in an experimental leukopenic mouse model.
Role of elastase as a virulence factor in experimental Pseudomonas aeruginosa infection in mice.
Role of elastase in a mouse model of chronic respiratory Pseudomonas aeruginosa infection that mimics diffuse panbronchiolitis.
Role of exotoxin A and proteases of Pseudomonas aeruginosa in respiratory tract infections.
Site-directed mutagenesis of Glu-141 and His-223 in Pseudomonas aeruginosa elastase: catalytic activity, processing, and protective activity of the elastase against Pseudomonas infection.
The bronchoalveolar lavage fluid of cystic fibrosis lung transplant recipients demonstrates increased interleukin-8 and elastase and decreased IL-10.
Therapeutic effect of immunization with OEP, protease toxoid and elastase toxoid on corneal ulcers in mice due to Pseudomonas aeruginosa infection.
Pseudoxanthoma Elasticum
Effect of selective enzymatic digestions on skin biopsies from pseudoxanthoma elasticum: an ultrastructural study.
Elastase digestion of normal and pseudoxanthoma elasticum lesional skin elastins.
Neutrophil elastase in patients with homozygous beta-thalassemia and pseudoxanthoma elasticum-like syndrome.
Psoriasis
Activity of some lysosomal enzyme in rheumatoid and psoriatic arthritis.
C-reactive protein and leucocyte activation in psoriasis vulgaris according to severity and therapy.
Cannabidiol Modifies the Formation of NETs in Neutrophils of Psoriatic Patients.
Decreased specific anti-elastase activity in the uninvolved skin of patients with psoriasis.
Deposition of elafin in the involved vascular wall of neutrophil-mediated cutaneous vasculitis.
Distribution of skin-derived antileucoproteases (SKALP) in the marginal zone of the spreading psoriatic lesion.
Elafin is induced in epidermis in skin disorders with dermal neutrophilic infiltration: interleukin-1 beta and tumour necrosis factor-alpha stimulate its secretion in vitro.
Enhanced Transdermal Peptide Delivery and Stability by Lipid Conjugation: Epidermal Permeation, Stereoselectivity and Mechanistic Insights.
Erythrocyte damage in mild and severe psoriasis.
Flavonoids as inhibitors of human neutrophil elastase.
Influence of TNF-alpha inhibitors and fumaric acid esters on male fertility in psoriasis patients.
Influence of traditional Chinese anti-inflammatory medicinal plants on leukocyte and platelet functions.
Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis.
Lesional elastase activity in psoriasis. Diagnostic and prognostic significance.
Levels of proelafin peptides in the sera of the patients with generalized pustular psoriasis and pustulosis palmoplantaris.
Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation to disease activity.
Quantitative assessments of physiological and biological parameters in psoriatic lesions and its correlations to the clinical severity of psoriasis.
Reduction of different inflammatory cell types of the innate immune system in psoriatic skin during etanercept treatment.
Skin-derived antileukoproteinase (SKALP) is decreased in pustular forms of psoriasis. A clue to the pathogenesis of pustule formation?
Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance.
The inflammatory response in mild and in severe psoriasis.
Topographic relation between skin-derived antileukoproteinase (SKALP) and leukocyte elastase in a case of annular pustular psoriasis.
Pterygium
The histochemical examination of the fibers of pterygium by elastase.
[Electron-microscopic and biochemical characteristics of pterygia (author's transl)]
Puerperal Infection
Protease production by microorganisms associated with reproductive tract infection.
Pulmonary Arterial Hypertension
Cathepsin S promotes the development of pulmonary arterial hypertension.
Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling.
Ellagic Acid Ameliorates Lung Inflammation and Heart Oxidative Stress in Elastase-Induced Emphysema Model in Rat.
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.
Pulmonary Aspergillosis
Biochemical and cellular activity of chemically synthesized elastase inhibitor (S-AFUEI) from Aspergillus fumigatus.
[Clinical analysis of chronic pulmonary aspergillosis and discovery of a elastase inhibitor]
[Studies on Elastase and Elastase Inhibitor from Aspergillus flavus].
Pulmonary Atelectasis
Manganese superoxide dismutase expression in alveolar type II epithelial cells from nonventilated and hypoperfused lungs.
Pulmonary Disease, Chronic Obstructive
3,4,5-Trihydroxycinnamic acid exerts a protective effect on pulmonary inflammation in an experimental animal model of COPD.
A controlled trial of colchicine to reduce the elastase load in the lungs of cigarette smokers with chronic obstructive pulmonary disease.
A controlled trial of colchicine to reduce the elastase load in the lungs of ex-cigarette smokers with chronic obstructive pulmonary disease.
A mathematical model of protease-antiprotease homeostasis failure in chronic obstructive pulmonary disease (COPD).
A monoclonal antibody with high affinity for a neo-antigenic site in fibrinogen degraded by polymorphonuclear leukocyte-derived elastase.
A study of common Mendelian disease carriers across ageing British cohorts: meta-analyses reveal heterozygosity for alpha 1-antitrypsin deficiency increases respiratory capacity and height.
Airway remodelling assessed by sputum and high-resolution computed tomography in asthma and COPD.
Alveolar macrophage function and inflammatory stimuli in smokers with and without obstructive lung disease.
Animal models of chronic obstructive pulmonary disease: some critical remarks.
Animal Models Related to Congenital Heart Disease and Clinical Research in Pulmonary Hypertension.
Antioxidant activity of carbocysteine lysine salt monohydrate.
Biochemical and pharmacological characterization of 2-(9-(2-piperidinoethoxy)-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor.
Bronchial inflammation: its relationship to colonizing microbial load and alpha(1)-antitrypsin deficiency.
Comparative proteome analysis of peripheral neutrophils from sulfur mustard-exposed and COPD patients.
Comparison of urinary desmosine excretion in patients with chronic obstructive pulmonary disease or cystic fibrosis.
Determinants of chronic obstructive pulmonary disease in patients with intermediate levels of alpha-antitrypsin.
Differences in responses upon corticosteroid therapy between smoking and non-smoking patients with COPD.
E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion.
Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome.
Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms.
Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro.
Effects of Wharton's jelly-derived mesenchymal stem cells on chronic obstructive pulmonary disease.
Elastase binding capacity of alpha 2-macroglobulin in plasma of patients with asthma or chronic obstructive pulmonary disease, without alpha 1-protease inhibitor deficiency.
Elastase- and LPS-exposed Mice Display Altered Responses to Rhinovirus Infection.
Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease.
Ethanol extract of the tuber of Alisma orientale reduces the pathologic features in a chronic obstructive pulmonary disease mouse model.
Evidence for excessive bronchial inflammation during an acute exacerbation of chronic obstructive pulmonary disease in patients with alpha(1)-antitrypsin deficiency (PiZ).
Expression of airway mucus-associated proteins in rats with chronic obstructive pulmonary disease with a cold-dryness symptom pattern.
Extracellular adenosine triphosphate and chronic obstructive pulmonary disease.
Gallic acid ameliorates COPD-associated exacerbation in mice.
Haemophilus influenzae induces neutrophil necrosis: a role in chronic obstructive pulmonary disease?
Human alveolar macrophage proteolytic enzyme activities in chronic obstructive pulmonary disease. Lack of correlation with functional abnormalities.
Interrelationships between neutrophil elastase, serum alpha, -antitrypsin, lung function and chest radiography in patients with chronic airflow obstruction.
Long-term clinical outcomes following treatment with alpha 1-proteinase inhibitor for COPD associated with alpha-1 antitrypsin deficiency: a look at the evidence.
Loss of FCHSD1 leads to amelioration of chronic obstructive pulmonary disease.
Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease.
MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD.
MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial.
Natural history of abdominal aortic aneurysm with and without coexisting chronic obstructive pulmonary disease.
Nicotine-stimulated elastase activity release by neutrophils in patients with abdominal aortic aneurysms.
Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.
Oxidant/antioxidant imbalance: role in the pathogenesis of COPD.
PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.
Piscroside C, a novel iridoid glycoside isolated from Pseudolysimachion rotundum var. subinegrum suppresses airway inflammation induced by cigarette smoke.
Preclinical animal models of asthma and chronic obstructive pulmonary disease.
Proteasome inhibition improves diaphragm function in an animal model for COPD.
Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.
Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD.
Relationship between the thickness of bronchial wall layers, emphysema score, and markers of remodeling in bronchoalveolar lavage fluid in patients with chronic obstructive pulmonary disease.
Role of Glucosylceramide in Lung Endothelial Cell Fate and Emphysema.
Role of neutrophils in mucus hypersecretion in COPD and implications for therapy.
Study on polymorphonucleocytal elastase-alpha 1-protease inhibitor complex in bronchoalveolar lavage fluid (BALF).
TAILS proteomics reveals dynamic changes in airway proteolysis controlling protease activity and innate immunity during COPD exacerbations.
The Natural Polypeptides as Significant Elastase Inhibitors.
The Plant-Derived Bauhinia bauhinioides Kallikrein Proteinase Inhibitor (rBbKI) Attenuates Elastase-Induced Emphysema in Mice.
Validity of HMGB1 measurement in epithelial lining fluid in patients with COPD.
Verification of zinc role in pathophysiology of chronic obstructive pulmonary disease.
[Changes of neutrophil elastase in COPD and the role of elastase in experimental pulmonary hypertension]
[Changes of serum elastase, alpha 1-antitrypsin, procollagen III peptide and malonaldehyde in smokers with and without chronic obstructive pulmonary diseases]
[Elastase activity of the sputum and the functional activity of serum alpha 1-antitrypsin in patients with chronic obstructive pulmonary disease]
[Elastase anti-elastase imbalance in the pathogenesis of COPD]
[Establishment of a novel mouse mode of elastase-induced chronic obstructive pulmonary disease related osteoporosis].
[Natural history of abdominal aortic aneurysm with and without concomitant chronic obstructive pulmonary disease]
Pulmonary Edema
Effect of a synthetic leukocyte elastase inhibitor on thrombin-induced pulmonary edema in the rat.
Effect of plant Kunitz inhibitors from Bauhinia bauhinioides and Bauhinia rufa on pulmonary edema caused by activated neutrophils.
Neutrophil recruitment and degranulation during induction of emphysema in the rat by nitrogen dioxide.
Neutrophils mediate acute lung injury in rabbits: role of neutrophil elastase.
Physiologic and morphologic observations of the effects of intravenous elastase on the lung.
[Usefulness of a protease inhibitor (urinastatin) in ARDS with infectious diseases]
Pulmonary Emphysema
A monoclonal antibody with high affinity for a neo-antigenic site in fibrinogen degraded by polymorphonuclear leukocyte-derived elastase.
Adenovirus vector expressing keratinocyte growth factor using CAG promoter impairs pulmonary function of mice with elastase-induced emphysema.
Amelioration of human neutrophil elastase-induced emphysema in hamsters by pretreatment with an oligopeptide chloromethyl ketone.
An animal model for lung volume reduction therapy of pulmonary emphysema.
An emphysema model in rats treated intratracheally with elastase.
Assessment of pulmonary microstructural changes by hyperpolarized (129)Xe diffusion-weighted imaging in an elastase-instilled rat model of emphysema.
Basic mechanisms leading to focal emphysema in coal workers' pneumoconiosis.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Blockade of Dopamine D2 Receptors as a Novel Approach to Stimulation of Notch1+ Endothelial Progenitor Cells and Angiogenesis in C57BL/6 Mice with Pulmonary Emphysema Induced by Proteases and Deficiency of ?1-Antitrypsin.
Bronchial mucus hypersecretion induced by elastase in hamsters: ultrastructural appearances.
Can exogenously administered hyaluronan improve respiratory function in patients with pulmonary emphysema?
Comparative studies of the elastin content of normal and emphysematous human lungs with special regard to antitrypsin deficiency.
Effects of intravenous prostaglandins F2 alpha and E2 in hypoxic and non-hypoxic rabbits with elastase induced emphysema.
Elastase release from human alveolar macrophages: comparison between smokers and nonsmokers.
Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis.
Emphysema alters the deposition pattern of inhaled particles in hamsters.
Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats.
Endothelial Progenitor Cells and Notch-1 Signaling as Markers of Alveolar Endothelium Regeneration in Pulmonary Emphysema.
Enhanced immediate inflammatory response to Streptococcus pneumoniae in the lungs of mice with pulmonary emphysema.
Erdosteine protection against cigarette smoking-induced functional antiprotease deficiency in human bronchiolo-alveolar structures.
Erythrocytes protect alpha-1-proteinase inhibitor from oxidative inactivation induced by chemicals, the myeloperoxidase-H2O2-halide system and stimulated polymorphonuclear leukocytes.
Evaluation of elastase and antielastase balance in patients with chronic bronchitis and pulmonary emphysema.
Evidence that genetic emphysema in tight-skin mice is not caused by neutrophil elastase.
Experimental pulmonary emphysema induced in the rat by intratracheally administered elastase: morphogenesis.
Experimental pulmonary histoplasmosis and emphysema.
Functional alpha 1-protease inhibitor in the lower respiratory tract of cigarette smokers is not decreased.
Heparin-binding EGF-like growth factor regulates elastin and FGF-2 expression in pulmonary fibroblasts.
Human alveolar macrophages secrete an inhibitor of metalloproteinase elastase.
Hypoxic injury to human alveolar macrophages accelerates release of previously bound neutrophil elastase. Implications for lung connective tissue injury including pulmonary emphysema.
Inactivation of alpha-1-proteinase inhibitor in serum by stimulated human polymorphonuclear leucocytes. Evidence for a myeloperoxidase-dependent mechanism.
Influence of experimental pulmonary emphysema on the toxicological effects from inhaled nitrogen dioxide and diesel exhaust.
Inhibition of elastase-induced acute inflammation and pulmonary emphysema in hamsters by a novel neutrophil elastase inhibitor FR901277.
Keratinocyte growth factor protects against elastase-induced pulmonary emphysema in mice.
Kinetics of equine neutrophil elastase release and superoxide anion generation following secretagogue activation: a potential mechanism for antiproteinase inactivation.
Leukoproteinases and pulmonary emphysema: cathepsin G and other chymotrypsin-like proteinases enhance the elastolytic activity of elastase on lung elastin.
Mesenchymal stromal cells-based therapy in a murine model of elastase-induced emphysema: Simvastatin as a potential adjuvant in cellular homing.
Morphogenesis of abnormal elastic fibers in lungs of patients with panacinar and centriacinar emphysema.
Oxidative and proteolysis-related parameters of skeletal muscle from hamsters with experimental pulmonary emphysema: a comparison between papain and elastase induction.
Oxidative stress and nitrosative stress are involved in different stages of proteolytic pulmonary emphysema.
Plasma elastin-derived peptide levels in normal adults, children, and emphysematous subjects. Physiologic and computed tomographic scan correlates.
Prevention of elastase-induced emphysema by aerosol administration of a specific synthetic elastase inhibitor.
Protective effect of specific elastase inhibitor in experimental pulmonary emphysema.
Pulmonary Emphysema Cross-Linking with Pulmonary Fibrosis and Vice Versa: a Non-usual Experimental Intervention with Elastase and Bleomycin.
Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity.
Retinoic acid fails to reverse emphysema in adult mouse models.
Sequential morphologic changes of elastase-induced pulmonary emphysema in pig lungs. Evaluation by high-resolution computed tomography.
Symptomatic pulmonary emphysema in childhood associated with hereditary alpha-1-antitrypsin and elastase inhibitor deficiency.
Testosterone deficiency promotes the development of pulmonary emphysema in orchiectomized mice exposed to elastase.
The antielastase screen of the lower respiratory tract.
The Pattern of Elastic Fiber Breakdown in Bleomycin-Induced Pulmonary Fibrosis May Reflect Microarchitectural Changes.
The Role of LTB4 in the Pathogenesis of Elastase Induced-Murine Pulmonary Emphysema.
Ultrastructural changes in hamster lung four hours to twenty-four days after exposure to elastase.
Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages.
[A study of antielastase activity in the development of pulmonary emphysema in a family with alpha 1-antitrypsin deficiency]
[Evaluation of desmosine excretion in urine and activity of elastase in neutrophils of patients with pulmonary emphysema]
[Experimental pulmonary emphysema in rats. Inflammatory phenomena and progression of lung damage]
[Experimental studies on the effect of tobacco smoke, vitamin C and vitamin E on elastase-induced pulmonary emphysema]
[Pulmonary emphysema induced by elastase: influence of the dose and effect of added collagenase]
[Pulmonary emphysema induced with elastase in the hamster: anatomical and anatomo-pathological aspects]
[Pulmonary emphysema--lung transplantation]
[Quantimetry and lung heterogeneity in hamsters (Mesocricetus auratus) treated with endotracheal or intrapleural infusion of elastase. Individual and contralateral variations]
Pulmonary Fibrosis
Administration of alpha 1-proteinase inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Administration of truncated secretory leukoprotease inhibitor ameliorates bleomycin-induced pulmonary fibrosis in hamsters.
Effects of elastase inhibitor on the epithelial cell apoptosis in bleomycin-induced pulmonary fibrosis.
Elastase modifies bleomycin-induced pulmonary fibrosis in mice.
Multispecific anti neutrophil cytoplasm antibodies: a case report.
Pulmonary Emphysema Cross-Linking with Pulmonary Fibrosis and Vice Versa: a Non-usual Experimental Intervention with Elastase and Bleomycin.
[Determination of elastase and alpha 2-macroglobulin in bronchoalveolar lavage fluid in patients with interstitial diseases and its clinical significance]
[Effects of elastase administration on experimental bleomycin-induced pulmonary fibrosis]
[Evaluation of matrix metaloproteinases (pro-mMP-1, MMP-2,8) and their inhibitor (TIMP-1) contents in patients with occupational lung diseases]
Pulmonary Heart Disease
The effect of oxygen on Cor pulmonale in experimental emphysema induced by elastase or elastase and beta-aminopropionitrile in hamsters.
[An experimental pathological study of the effect of bronchiolitis on emphysema and cor pulmonale pathogenesis]
Purpura
Concomitant Drug- and Infection-Induced Antineutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis with Multispecific ANCA.
Purpura, Thrombotic Thrombocytopenic
alpha 1-Antitrypsin therapy in a case of thrombotic thrombocytopenic purpura.
Pyelonephritis
Polymorphonuclear elastase as a diagnostic marker of acute pyelonephritis in children.
The possible role of granulocyte elastase in renal damage from acute pyelonephritis.
Renal Insufficiency
Serum elastase 1 in inflammatory pancreatic and gastrointestinal diseases and in renal insufficiency. A comparison with other serum pancreatic enzymes.
Serum levels of six pancreatic enzymes as related to the degree of renal dysfunction.
Systematic separation and purification of elastase, gelatinase (matrix metalloproteinase 9), and collagenase (matrix metalloproteinase 8) from polymorphonuclear leukocytes in dialyzers previously used by patients with renal failure.
Renal Insufficiency, Chronic
Changes in FGF-23, Neutrophil/Platelet Activation Markers, and Angiogenin in Advanced Chronic Kidney Disease and Their Effect on Arterial Stiffness.
Elastase and cathepsin G from primed leukocytes cleave vascular endothelial cadherin in hemodialysis patients.
Elastase, ?1-proteinase inhibitor, and interleukin-8 in pre-dialyzed and hemodialyzed patients with chronic kidney disease.
Flavonoids as inhibitors of human neutrophil elastase.
Reperfusion Injury
Early cellular brain damage and systemic inflammatory response after cardiopulmonary resuscitation or isolated severe head trauma: a comparative pilot study on common pathomechanisms.
Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart.
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury.
SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury.
Reproductive Tract Infections
Elastase as an indicator of silent genital tract infection in infertile men.
Respiratory Distress Syndrome
Adult respiratory distress syndrome (ARDS): experimental models with elastase and thrombin infusion in pigs.
Adult respiratory distress-like syndrome during hemodialysis: relationship between activation of complement, leukopenia, and release of granulocyte elastase.
Alveolar fluid neutrophil elastase activity in the adult respiratory distress syndrome is complexed to alpha-2-macroglobulin.
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia.
Competition between elastase and related proteases from human neutrophil for binding to alpha1-protease inhibitor.
Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia.
Elastase mimics pancreatitis-induced hepatic injury via inflammatory mediators.
Experimental studies on the adult respiratory distress syndrome: effects of induced DIC; granulocytes and elastase in mini pigs.
Experimental studies on the adult respiratory distress syndrome: elastase infusion in normal and agranulocytic minipigs.
Granulocytes in bronchial lavage fluid after major vascular surgery.
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
Increase in interleukin-8 and soluble intercellular adhesion molecule-1 in bronchoalveolar lavage fluid from premature infants who develop chronic lung disease.
Influence of heparin thromboprophylaxis on plasma leucocyte elastase levels following lobectomy for lung carcinoma.
Inhibition of granulocyte activation by surfactant in a 2-yr-old female with meningococcus-induced ARDS.
Interleukin 8 and granulocyte elastase in the tracheobronchial aspirate of infants without respiratory distress syndrome or intrauterine infection and development of chronic lung disease.
Intra-alveolar urinary trypsin inhibitor cannot inhibit polymorphonuclear elastase activity in the lung in postsurgical patients with acute respiratory distress syndrome.
Leucocyte elastase-mediated release of von Willebrand factor from cultured endothelial cells.
Neutrophil elastase and acute pulmonary damage in neonates with severe respiratory distress syndrome.
Oxygen exposure in the newborn guinea pig lung lavage cell populations, chemotactic and elastase response: a possible relationship to neonatal bronchopulmonary dysplasia.
Pancreatic elastase activates pulmonary nuclear factor kappa B and inhibitory kappa B, mimicking pancreatitis-associated adult respiratory distress syndrome.
Plasma elastase levels and the development of the adult respiratory distress syndrome.
Posttraumatic complications and inflammatory mediators.
Protease inhibitors in bronchoalveolar lavage fluid from neonates with special reference to secretory leukocyte protease inhibitor.
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents.
Serial measurements of plasma elastase alpha 1-proteinase inhibitor complexes in patients receiving cancer chemotherapy.
Simultaneous measurement of endothelial cell damage, elastase release and chemiluminescence response during interaction between polymorphonuclear leukocytes and endothelial cells.
The Natural Polypeptides as Significant Elastase Inhibitors.
The role of neutrophil elastase in chronic inflammation.
The value of polymorphonuclear elastase in adult respiratory distress syndrome.
[Plasma concentration of polymorphonuclear elastase as an early marker of respiratory distress syndrome]
[Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy]
Respiratory Hypersensitivity
A short-term mouse model that reproduces the immunopathological features of rhinovirus-induced exacerbation of COPD.
Respiratory Insufficiency
Continuous intravenous infusion of elastase in normal and agranulocytic minipigs--effects on the lungs and the blood coagulation system.
Experimental studies on the adult respiratory distress syndrome: effects of induced DIC; granulocytes and elastase in mini pigs.
[Acute respiratory failure due to pneumocystis pneumonia successfully treated with combined use of sivelestat sodium hydrate]
[ARDS-like reactive respiratory failure after radical operation for esophageal cancer--with reference to PMN elastase and anaphylatoxin]
Respiratory Tract Infections
[Elastase activity in bronchoalveolar lavage fluid from patients with chronic respiratory tract infections]
Rheumatic Diseases
Serum inhibitors of elastase, trypsin, and plasmin in chronic rheumatic diseases.
[Modification of systemic signs and elastase in neutrophilic granulocytes in inflammatory rheumatic diseases in childhood by immunoglobulin therapy]
Rhinitis
Mediators and cytokines in allergic and viral-triggered rhinitis.
Rhinitis, Allergic
Nasal response to capsaicin in patients with allergic rhinitis and in healthy volunteers: effect of colchicine.
The effect of immediate-hypersensitivity reactions on the level of SLPI, granulocyte elastase, alpha1-antitrypsin, and albumin in nasal secretions, by the method of unilateral antigen challenge.
Sarcoidosis
Cigarette smoking and sarcoidosis.
Circulating human leucocyte elastase levels in patients with pulmonary sarcoidosis.
Elastase activity of bronchoalveolar cells in advanced pulmonary sarcoidosis.
Elevated serum superoxide dismutase levels correlate with disease severity and neutrophil degranulation in idiopathic pulmonary fibrosis.
Phagocyte enzymes in bronchoalveolar lavage from patients with pulmonary sarcoidosis and collagen vascular disorders.
Prognostic value of plasma neutrophil elastase levels in pulmonary sarcoidosis.
The elastase: anti-elastase profile in lung lavage from sarcoidosis patients.
[Antimicrobial activity of blood phagocytes in patients with tuberculosis and respiratory sarcoidosis]
[Elastase and alpha-1 proteinase inhibitor complex in broncho-alveolar lavage fluid in patients with bronchial asthma and sarcoidosis]
Sarcoidosis, Pulmonary
Circulating human leucocyte elastase levels in patients with pulmonary sarcoidosis.
Elastase activity of bronchoalveolar cells in advanced pulmonary sarcoidosis.
[Oxygen radical formation in pulmonary sarcoidosis. The signs of early macrophage activation]
Sarcoma
Neutrophil elastase-dependent cleavage compromises the tumor suppressor role of EMILIN1.
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer.
Sarcoma, Experimental
A novel disulfide pattern in laminin-type epidermal growth factor-like (LE) modules of laminin ?1 and ?1 chains.
Sarcoma, Myeloid
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
Schistosomiasis
[Pulmonary schistosomiasis. Identification and determination of elastase in platelets and its role in the development of Schistosoma mansoni granuloma]
Scleroderma, Systemic
Decreased elastase activity in circulating granulocytes of systemic sclerosis patients: a possible pathogenetic role.
Elevated Serum Concentrations of Polymorphonuclear Neutrophilic Leukocyte Elastase in Systemic Sclerosis: Association with Pulmonary Fibrosis.
Elevated serum concentrations of polymorphonuclear neutrophilic leukocyte elastase in systemic sclerosis: association with pulmonary fibrosis.
MMP-12 deficiency attenuates angiotensin II-induced vascular injury, M2 macrophage accumulation, and skin and heart fibrosis.
The pharmacological effects of cicaprost, an oral prostacyclin analogue, in patients with Raynaud's syndrome secondary to systemic sclerosis--a preliminary study.
Sepsis
Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis.
Coagulation inhibitor substitution during sepsis.
CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase.
Detection of synovial sepsis in horses using enzymes as biomarker.
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6.
Effect of passive immunotherapy on murine gut-derived sepsis caused by Pseudomonas aeruginosa.
Efficacies of alkaline protease, elastase and exotoxin A toxoid vaccines against gut-derived Pseudomonas aeruginosa sepsis in mice.
Elastase mediated fibrinolysis in acute promyelocytic leukemia.
Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats.
Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis.
Factor V cleavage and inactivation are temporally associated with elevated elastase during experimental sepsis.
Granulocyte elastase compared to C-reactive protein for early diagnosis of septicemia in critically ill patients.
High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis.
Inter-alpha-inhibitor as marker for neutrophil proteinase activity: an in vitro investigation.
Interleukin 8-related neutrophil elastase and the severity of the adult respiratory distress syndrome.
Intestinal permeability changes, systemic endotoxemia, inflammatory serum markers and sepsis after Whipple's operation for carcinoma of the pancreas head.
Leucocyte elastase-mediated release of von Willebrand factor from cultured endothelial cells.
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Neutrophil activation in acute renal failure and sepsis.
Pathobiochemistry of sepsis: role of proteinases, proteinase inhibitors and oxidizing agents.
Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis.
Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects.
Pseudomonas aeruginosa alkaline proteinase might share a biological function with plasmin.
Quantification of NETs formation in neutrophil and its correlation with the severity of sepsis and organ dysfunction.
Released granulocytic elastase: an indicator of pathobiochemical alterations in septicemia after abdominal surgery.
Role of Hageman factor/kallikrein-kinin system in pseudomonal elastase-induced shock model.
Septic Complications after Resection for Middle or Low Rectal Cancer: Role of Gut Barrier Function and Inflammatory Serum Markers.
The inactivation of antithrombin III by serum elastase in patients with surgical infections.
The Natural Polypeptides as Significant Elastase Inhibitors.
Time-dependent association between coagulation factor inactivation and increased elastase during experimental sepsis.
Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice.
[Neutrophil elastase level in cord blood and diagnosis of infection in mature and premature neonates]
[Thromboxane A2 and granulocyte elastase after severe trauma--relationship to complications and survival rates]
Severe Acute Respiratory Syndrome
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity.
Severe Dengue
Dengue virus infection: predictors for severe dengue.
Shock, Septic
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor.
DNA-bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma.
Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock.
Effect of the elastase inhibitor eglin C in porcine endotoxin shock.
Further evidence of bradykinin involvement in septic shock: reduction of kinin production in vivo and improved survival in rats by use of polymer tailored SBTI with longer t1/2.
Pathobiochemistry of sepsis: role of proteinases, proteinase inhibitors and oxidizing agents.
Role of alpha-2-macroglobulin and bacterial elastase in guinea-pig pseudomonal septic shock.
Silicosis
[Status of the protease inhibitor system in patients with dust-induced lung diseases]
Sinusitis
ELISA for determination of immunoreactive free elastase and elastase in complex with alpha 1-antitrypsin in nasal secretions with sinusitis.
The neutrophil and chronic allergic inflammation. Immunochemical localization of neutrophil elastase.
Skin Abnormalities
alpha1-Antitrypsin deficiency and skin abnormalities.
Skin Diseases, Vesiculobullous
Demonstration of collagenase and elastase activities in the blister fluids from bullous skin diseases. Comparison between dermatitis herpetiformis and bullous pemphigoid.
The generation of a human dermal equivalent to assess the potential contribution of human dermal fibroblasts to the sulphur mustard-induced vesication response.
Spinal Cord Injuries
A neutrophil elastase inhibitor (ONO-5046) reduces neurologic damage after spinal cord injury in rats.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Spondylitis, Ankylosing
Circulating inhibitor bound elastase in patients with ankylosing spondylitis and rheumatoid arthritis and the influence of sulphasalazine treatment.
Neutral protease, collagenase and elastase activities in synovial fluids from arthritic patients.
Staphylococcal Infections
Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockers in Vitro and in Vivo.
Starvation
A comparison of starvation and elastase models of emphysema in the rat.
A dual regulatory circuit consisting of S-adenosylmethionine decarboxylase protein and its reaction product controls expression of the paralogous activator prozyme in Trypanosoma brucei.
Starvation selection restores elastase and rhamnolipid production in a Pseudomonas aeruginosa quorum-sensing mutant.
[Activity of elastase and its inhibitors in tissues of aorta and blood serum in various types of acidosis]
Steatorrhea
Chronic pancreatitis.
Duodenal-preserving resection of the head of the pancreas and pancreatic head resection with second-portion duodenectomy for benign lesions, low-grade malignancies, and early carcinoma involving the periampullary region.
Effects of pancreatectomy on nutritional state, pancreatic function, and quality of life over 5 years of follow up.
Fecal Elastase Fails to Detect Steatorrhea in Patients With Locally Advanced Pancreatic Cancer.
Maldigestion from pancreatic exocrine insufficiency.
Pancreatic exocrine insufficiency in HIV-positive patients.
Presence of SPINK-1 variant alters the course of chronic pancreatitis.
Prevalence of End-Organ Damage, Beta Cell Reserve, and Exocrine Pancreas Defect in Fibrocalculous Pancreatic Diabetes: An Eastern India Perspective.
Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations.
[Pancreatic exocrine function in diabetes mellitus: Determination of fecal elastase.]
Stroke
Calcium-dependent bidirectional power stroke of the dynein arms in sea urchin sperm axonemes.
Neutrophil elastase inhibitor prevents ischemic brain damage via reduction of vasogenic edema.
Polymorphonuclear leukocyte elastase in patients with stroke.
Related age changes in the elastase and lipid contents of normal and hemiplegic subjects of various ages.
Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques: the Etude sur le Vieillissement Artériel (EVA) study.
Serum elastase levels following a stroke in elderly subjects.
Synovitis
Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis.
Matrix metalloproteinase-13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha-1 antitrypsin: Implications for osteoarthritis.
Systemic Vasculitis
Anti-neutrophil cytoplasmic antibodies: a new class of autoantibodies in glomerulonephritis, vasculitis and other inflammatory disorders.
Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.
Tachycardia
[The Churg-Strauss syndrome]
Takayasu Arteritis
Studies on the pathogenesis of pulseless disease, especially on experimental angiitis by elastase.
Tendinopathy
Degradation of elastic fiber and elevated elastase expression in long head of biceps tendinopathy.
Peritendinous elastase treatment induces tendon degeneration in rats: A potential model of tendinopathy in vivo.
Tetanus
Capsular polysaccharide-protein conjugate vaccines of carbotype 1 Vibrio vulnificus: construction, immunogenicity, and protective efficacy in a murine model.
Thromboangiitis Obliterans
Study of anti-neutrophil cytoplasmic antibodies in patients with thromboangiitis obliterans (Buerger's disease).
Thromboembolism
Blood cells diseases and thrombosis.
Thromboinflammation
Hypothesis: Alpha-1-antitrypsin is a promising treatment option for COVID-19.
Thrombophilia
Loss of blast cell procoagulant activity and improvement of hemostatic variables in patients with acute promyelocytic leukemia administered all-trans-retinoic acid.
The inactivation of antithrombin III by serum elastase in patients with surgical infections.
Thrombosis
A novel chronic advanced stage abdominal aortic aneurysm murine model.
Activities of proteases in parietal thrombus of aortic aneurysm.
Circulating nucleosomes and elastase ?1-antitrypsin complexes and the novel thrombosis susceptibility locus SLC44A2.
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit.
Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
Elastase inhibitor AZD9668 treatment prevented progression of experimental abdominal aortic aneurysms.
Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with deep vein thrombosis.
Enhanced matrix-degrading proteolytic activity within the thin thrombus-covered wall of human abdominal aortic aneurysms.
Fusiform Aneurysm Model in Rabbit Carotid Artery.
HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property.
Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice.
Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: beneficial effects on myocardial histology.
Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy.
Neutrophils stimulated by apolipoprotein(a) generate fragments that are stronger inhibitors of plasmin formation than apo(a).
Role of leukocyte elastase in preventing cellular re-colonization of the mural thrombus.
The inactivation of antithrombin III by serum elastase in patients with surgical infections.
The pathology of elastase-induced panacinar emphysema in hamsters.
The recombinant plant Bauhinia bauhinioides elastase inhibitor reduces rat thrombus without alterations in hemostatic parameters.
Ultrasmall superparamagnetic iron oxide nanoparticles coated with fucoidan for molecular MRI of intraluminal thrombus.
[Disruption of regulatory possibilities of the plasma kallikrein-kinin system in chronic kidney failure and during hemodialysis]
[Fibrinolysis modulators]
Tinea
Elastase: production by ringworm fungi.
Extracellular proteolytic activity and molecular analysis of Microsporum canis strains isolated from symptomatic and asymptomatic cats.
[Exoenzymes of dermatophytes isolated from acute and chronic tinea]
[The relation between the growth and extracellular proteolytic activity in trichophyton rubrum, comparing isolates from granuloma trichophyticum with tinea superficialis]
Tonsillitis
[Behavior of leukocyte elastase in chronic inflammatory tonsillar diseases]
Tuberculosis
Identification of an elastolytic protease in stationary phase culture filtrates of M. tuberculosis.
Neutrophil extracellular traps in patients with pulmonary tuberculosis.
[Blood elastase in tuberculosis and other lung diseases]
[Leukocyte elastase in blood plasma from tuberculosis patients and its role in disturbances of blood coagulation regulatory processes]
[Mechanisms of development of antiproteolytic deficiency in tuberculosis and in nonspecific lung diseases]
[Serum neutrophil elastase and activity of its inhibitors in patients with pulmonary tuberculosis]
Tuberculosis, Pleural
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
Tuberculosis, Pulmonary
Mycobacterium tuberculosis strains modify granular enzyme secretion and apoptosis of human neutrophils.
PARTICULAR QUALITIES OF THE PROTEOLYTIC SYSTEM IN PATIENTS WITH TUBERCULOSIS DEPENDING ON THE SENSITIVITY OF THE PATHOGEN.
[Antimicrobial activity of blood phagocytes in patients with tuberculosis and respiratory sarcoidosis]
[Local immune and inhibitor protection in patients with newly detected destructive pulmonary tuberculosis complicated by nonspecific endobronchitis]
[Serum neutrophil elastase and activity of its inhibitors in patients with pulmonary tuberculosis]
Uremia
Granulocyte lysosomal factors and plasma elastase in uremia: a potential factor of catabolism.
Influence of SPK with Enteric Drainage on the Pancreatic Exocrine Function in Diabetic Patients with Uremia.
Release of granulocyte neutral proteinases in patients with acute and chronic renal failure.
Urethritis
Neutrophil enzymes in urine for the detection of urethral infection in men.
Urinary Bladder Neoplasms
Elastase activities of human bladder cancer cell lines derived from high grade invasive tumours.
Elastase--does this enzyme play any role in bladder cancer invasion?
Urinary Incontinence
Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?
Urinary Tract Infections
Epidemic population structure of Pseudomonas aeruginosa: evidence for a clone that is pathogenic to the eye and that has a distinct combination of virulence factors.
Multiple virulence factors regulated by quorum sensing may help in establishment and colonisation of urinary tract by Pseudomonas aeruginosa during experimental urinary tract infection.
Plasma and urine elastase alpha-1-proteinase inhibitor levels in neonatal urinary tract infection.
Urticaria
Immunohistological comparison of granulated cell proteins in induced immediate urticarial dermographism and delayed pressure urticaria lesions.
Uterine Cervical Neoplasms
Biochemical markers as a predictor for lymph-node involvement in patients with cervical-cancer of the uterus.
Uterine Cervicitis
[Intravaginal bacterial flora and clinical significance of granulocyte elastase and pH determination]
Uveitis
Chemoattractant and neutrophil degranulation activities related to interleukin-8 in vitreous fluid in uveitis and vitreoretinal disorders.
The importance of plasma polymorphonuclear (PMN) elastase determination in patients with uveitis.
Vaginitis
[Intravaginal bacterial flora and clinical significance of granulocyte elastase and pH determination]
Vaginosis, Bacterial
Increased level of granulocyte elastase in cervical secretion is an independent predictive factor for preterm delivery.
Varicose Ulcer
Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation.
Varicose Veins
Plasma elastase in venous disease.
Vascular Calcification
Sequential activation of matrix metalloproteinase 9 and transforming growth factor beta in arterial elastocalcinosis.
Vascular Diseases
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor.
Elastase and cell matrix interactions in the pathobiology of vascular disease.
Elastase and matrix metalloproteinase activities are associated with pulmonary vascular disease in the nitrofen rat model of congenital diaphragmatic hernia.
Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease.
Elastase-type activity, elastase inhibitory capacity, lipids and lipoproteins in the sera of patients with ischemic vascular disease.
Elastase-type enzymes and their relation to blood lipids in atherosclerotic patients.
Extra- and Intraluminal Elastase Induce Morphologically Distinct Abdominal Aortic Aneurysms in Mice and Thus Represent Specific Subtypes of Human Disease.
Nicotine-stimulated elastase activity release by neutrophils in patients with abdominal aortic aneurysms.
Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP-mediated suppression of ERK phosphorylation and AML1B nuclear partitioning.
Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis.
Serum elastase-type enzymes and their correlation to blood lipids in male patients with atherosclerosis.
[Effect of elastase inhibitor on pulmonary hypertension induced by monocrotaline]
[Serum elastinolytic activity and blood lipids in various clinical forms of arteriosclerosis and in acute myocardial infarct]
Vascular System Injuries
Bacterial lipopolysaccharide enhances chemoattractant-induced elastase secretion by human neutrophils.
Protection of vascular basement membrane and microcirculation from elastase-induced damage with a fluorinated beta-lactam derivative.
Pulmonary vascular injury in pancreatitis: evidence for a major role played by pancreatic elastase.
Spontaneous rupture of hepatocellular carcinoma and vascular injury.
Vasculitis
Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase.
Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity.
Complexed plasma elastase as an in vivo marker for leukocyte activation in antineutrophil cytoplasmic antibody-associated vasculitis.
Membrane surface proteinase 3 expression and intracytoplasmic immunoglobulin on neutrophils from patients with ANCA-associated vasculitides.
Neutrophil Extracellular Traps and By-Products Play a Key Role in COVID-19: Pathogenesis, Risk Factors, and Therapy.
Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules.
Prevalence and characterization of neutrophil cytoplasmic antibodies in autoimmune liver diseases.
Studies on the pathogenesis of pulseless disease, especially on experimental angiitis by elastase.
Tubulointerstitial nephritis and vasculitis.
[Propylthiouracil-induced multispecific antineutrophil cytoplasmic antibodies]
Vasculitis, Central Nervous System
Detection of autoantibodies against myeloid lysosomal enzymes: a useful adjunct to classification of patients with biopsy-proven necrotizing arteritis.
Venous Insufficiency
Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration.
Venous Thrombosis
Elevated plasma levels of fibrin degradation products by granulocyte-derived elastase in patients with deep vein thrombosis.
Ventilator-Induced Lung Injury
Effect of Ono-EI-600 elastase inhibitor on high-tidal-volume-induced lung injury in rats.
Virus Diseases
Inflammatory mediators in dengue virus infection in children: interleukin-8 and its relationship to neutrophil degranulation.
Vitamin A Deficiency
Neutrophil cathepsin G is specifically decreased under vitamin A deficiency.
Vitamin D Deficiency
Lack of pancreatic body and tail in HNF1B mutation carriers.
Prevalence and predictive factors of undernutrition and low bone mineral density in children with chronic pancreatitis.
Vitamin E Deficiency
Lack of pancreatic body and tail in HNF1B mutation carriers.
von Willebrand Diseases
Evidence that calpains and elastase do not produce the von Willebrand factor fragments present in normal plasma and IIA von Willebrand disease.
Whooping Cough
Calcium changes in immune complex-stimulated human neutrophils. Simultaneous measurement of receptor occupancy and activation reveals full population stimulus binding but subpopulation activation.
Wound Infection
Novel peptidoglycan-based diagnostic devices for detection of wound infection.
Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections.