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Disease on EC 3.4.21.59 - Tryptase

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DISEASE
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Abortion, Spontaneous
High levels of intrauterine corticotrophin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions.
High levels of intrauterine corticotropin-releasing hormone, urocortin, tryptase, and interleukin-8 in spontaneous abortions.
Abscess
Activation of mast cells in skin abscess induced by Staphylococcus aureus (S. aureus) infection in mice.
Acquired Immunodeficiency Syndrome
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Mast cell tryptase as a target for drug design.
Postmortem findings after anaphylactic reactions to drugs in Turkey.
Acute Coronary Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Kounis Syndrome as First Manifestation of Allergic Sensitization.
Mast cell tryptase: a new biomarker in patients with stable coronary artery disease.
Mast cells and acute coronary syndromes: relationship between serum tryptase, clinical outcome and severity of coronary artery disease.
No long-lasting or intermittent mast cell activation in acute coronary syndromes.
Serum tryptase detected during acute coronary syndrome is significantly related to the development of major adverse cardiovascular events after 2 years.
Serum tryptase levels in acute coronary syndromes with ST elevation.
Serum tryptase levels in acute coronary syndromes.
Tryptase levels in patients after acute coronary syndromes: the potential new marker of an unstable plaque?
Acute Lung Injury
Mast-Cell-Releasing Tryptase Triggers Acute Lung Injury Induced by Small Intestinal Ischemia-Reperfusion by Activating PAR-2 in Rats.
Physiology and pathophysiology of proteinase-activated receptors (PARs): role of tryptase/PAR-2 in vascular endothelial barrier function.
Adenocarcinoma
Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma.
Mast Cells and Proteins Related to Myofibroblast Differentiation (PAR-2, IL-6, and TGF?1) in Salivary Cancers: A Preliminary Study.
Mast cells density positive to tryptase correlates with angiogenesis in pancreatic ductal adenocarcinoma patients having undergone surgery.
Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
Adenocarcinoma of Lung
Chymase-positive mast cells in small sized adenocarcinoma of the lung.
Adenoma
Density of mast cells and microvessels in minor salivary gland tumors.
Higher intratumoral expression of CD1a, tryptase, and CD68 in a follicular variant of papillary thyroid carcinoma compared to adenomas: correlation with clinical and pathological parameters.
Agammaglobulinemia
KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
Airway Obstruction
Experimental rhinovirus 16 infection potentiates histamine release after antigen bronchoprovocation in allergic subjects.
Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma.
The immunopharmacology of mild asthma.
Alopecia
Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium.
Alopecia Areata
Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium.
Alveolitis, Extrinsic Allergic
Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease.
Alzheimer Disease
New biological functions of intracellular proteases and their endogenous inhibitors as bioreactants.
Ameloblastoma
A positive correlation between immunohistochemical expression of CD31 and mast cell tryptase in odontogenic tumors.
Anaphylaxis
A 48-year-old female with perioperative anaphylaxis.
A case of levofloxacin-induced anaphylaxis with elevated serum tryptase levels.
A case of midazolam anaphylaxis.
A case of sudden death after Japanese encephalitis vaccination.
A Decline in 2 Consecutive Postmortem Serum Tryptase Levels in an Anaphylactic Death.
A humanized mouse model of anaphylactic peanut allergy.
A patient with anaphylaxis after alteplase infusion.
A pediatric case of anaphylaxis caused by matsutake mushroom (Tricholoma matsutake) ingestion.
A Prospective Observation of Psychological Distress in Patients With Anaphylaxis.
A rapid increase in foot tissue temperature predicts cardiovascular collapse during anaphylactic and anaphylactoid reactions.
A rare case of lactation anaphylaxis.
Accumulation of eosinophils, mast cells, and basophils in the spleen in anaphylactic deaths.
Active monomers of human beta-tryptase have expanded substrate specificities.
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation.
Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009.
Airway function correlates with circulating eosinophil, but not mast cell, markers of inflammation in childhood asthma.
Allergic Reactions During Anesthesia at a Large United States Referral Center.
Allergic transfusion reactions: an evaluation of 273 consecutive reactions.
Amniotic fluid embolism induces uterine anaphylaxis and atony following cervical laceration.
Amniotic fluid embolism, anaphylaxis, and tryptase.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
An analysis of possible mechanisms of unexpected death occurring in hydatid disease (echinococcosis).
An autopsy approach to bee sting-related deaths.
An autopsy case of fatal anaphylactic shock following fluorescein angiography: a case report.
Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000.
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Anaphylactic reaction to white-faced hornet sting and elevated baseline (asymptomatic) serum tryptase.
Anaphylactic reactions during anaesthesia and the perioperative period.
Anaphylactic Shock After Intravenous Fluorescein Administration for Intraoperative Cystoscopy.
Anaphylactic shock due to cefuroxime in a patient taking penicillin prophylaxis.
Anaphylactoid reaction during first hemofiltration?with a PUREMA® polysulfone membrane.
Anaphylactoid reaction to intravenous contrast in patient with systemic mastocytosis.
Anaphylactoid reaction to protamine confirmed by plasma tryptase in a diabetic patient during open heart surgery.
Anaphylactoid shock in a patient following 5% human serum albumin infusion during off-pump coronary artery bypass grafting.
Anaphylaxis and Clinical Utility of Real-World Measurement of Acute Serum Tryptase in UK Emergency Departments.
Anaphylaxis caused by neostigmine.
Anaphylaxis during anaesthesia: diagnostic approach.
Anaphylaxis during negative penicillin skin prick testing confirmed by elevated serum tryptase.
Anaphylaxis during the perioperative period.
Anaphylaxis following administration of intravenous methylprednisolone sodium succinate in a renal transplant recipient.
Anaphylaxis in an urban Belgian emergency department: epidemiology and aetiology.
Anaphylaxis in children.
Anaphylaxis in late pregnancy: plasma concentrations of histamine, tryptase and IgE in the neonate.
Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients.
Anaphylaxis is a rare reaction in COVID-19 vaccination.
Anaphylaxis secondary to albumin infusion during posterior spinal fusion for pediatric scoliosis.
Anaphylaxis should be considered to be a potential cause of stuporous state.
Anaphylaxis to anaesthetic drugs.
Anaphylaxis to goat/sheep's milk in a 4-year-old boy tolerant to cow's milk.
Anaphylaxis to insect stings.
Anaphylaxis to intrathecal diamorphine.
Anaphylaxis to intravenous amiodarone.
Anaphylaxis to isosulfan blue dye during sentinel lymph node biopsy.
Anaphylaxis to omeprazole.
Anaphylaxis to Patent Blue V. I. Clinical aspects.
Anaphylaxis to Patent Blue V: a case series.
Anaphylaxis with clonal mast cells in normal looking skin - a new entity?
Anaphylaxis with elevated serum tryptase after administration of intravenous ferumoxytol.
Anaphylaxis.
Anaphylaxis: Recognition and Management.
Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years).
Angio-oedema following rectal diclofenac after caesarean section.
Atypical anaphylactic reaction to Patent Blue during sentinel lymph node biopsy for breast cancer.
Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly.
Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old.
Basal Tryptase Levels Can Predict Clinical Severity in Hymenoptera Venom Anaphylaxis and Ischemic Cardiovascular Disorders.
Biochemical markers of anaphylactoid reactions to drugs. Comparison of plasma histamine and tryptase.
Biomarkers in Human Anaphylaxis: A Critical Appraisal of Current Evidence and Perspectives.
Biomarkers of anaphylaxis, beyond tryptase.
Bone Marrow Mastocytosis: A Diagnostic Challenge.
BSACI guidelines for the investigation of suspected anaphylaxis during general anaesthesia.
Can serum mast cell tryptase help diagnose anaphylaxis?
Cardiac arrest following an anaphylactic reaction to atracurium.
Cardiovascular aspects of anaphylaxis: implications for treatment and diagnosis.
Cardiovascular disease and anaphylaxis.
Cardiovascular symptoms in patients with systemic mast cell activation disease.
Case Report: Mastocytosis: The Long Road to Diagnosis.
Catheter-induced anaphylaxis and determination of the causative catheter in a patient undergoing neuroendovascular surgery: a case report.
Chapter 25: Idiopathic anaphylaxis.
Characteristics and Treatment of Anaphylaxis in Children Visiting a Pediatric Emergency Department in Korea.
Chlorpheniramine-induced anaphylaxis: Two case reports and a retrospective review of pharmacovigilance database.
Clinical Manifestations and Causes of Anaphylaxis. Analysis of 382 Cases from the Anaphylaxis Registry in West Pomerania Province in Poland.
Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings.
Current Knowledge and Management of Hypersensitivity to Perioperative Drugs and Radiocontrast Media.
Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis: relationship with basal serum tryptase.
Cutaneous mastocytosis treatment: strategies, limitations and perspectives.
Death due to blood transfusion-induced anaphylactic shock: A case report.
Death in anaphylaxis in a man with house dust mite allergy.
Decline in 2 Serial Postmortem Tryptase Measurements Beyond 72 Hours After Death in an Antibiotic-Related Anaphylactic Death.
Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis.
Delayed food-dependent, exercise-induced anaphylaxis.
Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis.
Diagnosis and pathogenesis of the anaphylactic and anaphylactoid reactions to anaesthetics.
Diagnosis of Hymenoptera venom allergy.
Diagnosis of IgE-dependent anaphylaxis to neuromuscular blocking drugs, thiopentone and opioids.
Diagnosis of perioperative anaphylaxis.
Diagnostic role of serum tryptase in anaphylactic deaths in forensic medicine: a systematic review and meta-analysis.
Diagnostic value of histamine and tryptase concentrations in severe anaphylaxis with shock or cardiac arrest during anesthesia.
Diagnostic value of tryptase in anaphylaxis and mastocytosis.
Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges.
Differences Between Central and Peripheral Postmortem Tryptase Levels.
Differences in sampling techniques on total post-mortem tryptase.
Differential accumulation of pulmonary and cardiac mast cell-subsets and eosinophils between fatal anaphylaxis and asthma death: a postmortem comparative study.
Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis.
Drug hypersensitivity in clonal mast cell disorders: ENDA/EAACI position paper.
Drug-Induced Anaphylaxis Documented in Electronic Health Records.
EAACI guideline: Anaphylaxis (2021 update).
Early diagnosis of anaphylactic reactions to neuromuscular blocking drugs.
Effect of a cocoa-enriched diet on immune response and anaphylaxis in a food allergy model in Brown Norway rats.
Effect of general anesthesia and orthopedic surgery on serum tryptase.
Effector cells of anaphylaxis: mast cells and basophils.
Efficacy of Omalizumab in Indolent Systemic Mastocytosis.
Electromagnetic field induced biological effects in humans.
Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy.
Elevated baseline mast cell tryptase: a marker of severe insect venom anaphylaxis.
Elevated baseline serum tryptase, mastocytosis and anaphylaxis.
Elevated postmortem tryptase in the absence of anaphylaxis.
Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms.
Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions.
Elevated serum tryptase in exercise-induced anaphylaxis.
Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review.
Elevated serum tryptase level in a case of intraoperative anaphylaxis caused by latex allergy.
Elevated serum tryptase levels in a patient with protracted anaphylaxis.
Enteral and systemic release of leukotrienes during anaphylaxis of Nippostrongylus brasiliensis-primed rats.
Epidemiology, Mechanisms, and Diagnosis of Drug-Induced Anaphylaxis.
Epidemiology, prognosis, and risk factors in mastocytosis.
Evaluation of mast cell activation (tryptase) in two patients suffering from drug-induced hypotensoid reactions.
Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis.
Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor: A case report.
Expression of alpha-tryptase and beta-tryptase by human basophils.
Factors that predict disease severity in atopic dermatitis: The role of serum basal tryptase.
Fatal anaphylactic reactions to lignocaine.
Fatal Anaphylaxis to Atracurium: A Case Report.
Fatal anaphylaxis: postmortem findings and associated comorbid diseases.
Fatal food-induced anaphylaxis: Determination of tryptase and specific IgE on cadaveric blood samples. What else for a better methodological standard?
Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood.
Food anaphylaxis.
Food-Dependent Exercise-Induced Anaphylaxis due to Wheat in a Young Woman.
Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond.
Gut mucosal mast cells in Nippostrongylus-primed rats are the major source of secreted rat mast cell protease II following systemic anaphylaxis.
Heparin-induced recurrent anaphylaxis.
Heritable risk for severe anaphylaxis associated with increased ?-tryptase-encoding germline copy number at TPSAB1.
Higher mast cell load decreases the risk of Hymenoptera venom-induced anaphylaxis in patients with mastocytosis.
Histamine, tryptase, norepinephrine, angiotensinogen, angiotensin-converting enzyme, angiotensin I and II in plasma of patients with hymenoptera venom anaphylaxis.
How much specific is the association between hymenoptera venom allergy and mastocytosis?
How to interpret mast cell tests.
Human mast cell tryptase in biology and medicine.
Hymenoptera venom allergy.
Hymenoptera-induced anaphylaxis: is it a mast cell driven hematological disorder?
Hypersensitivity to Rituximab in Children.
Hyperthermia after cardiac surgery.
Hypotensive shock and angio-oedema from angiotensin II receptor blocker: a class effect in spite of tripled tryptase values.
Idiopathic anaphylaxis.
Idiopathic Anaphylaxis: A Form of Mast Cell Activation Syndrome.
Immunoassays in the diagnosis of anaphylaxis to neuromuscular blocking drugs: the value of morphine for the detection of IgE antibodies in allergic subjects.
Immunotoxic effects of atrazine and its main metabolites at environmental relevant concentrations on larval zebrafish (Danio rerio).
Impact of Age and Heterophilic Interference on the Basal Serum Tryptase, a Risk Indication for Anaphylaxis, in 1,092 Dermatology Patients.
Improved diagnosis of anaphylactoid reactions by measurement of serum tryptase and urinary methylhistamine.
Improving diagnostic accuracy of anaphylaxis in the acute care setting.
In vitro diagnosis of anaphylaxis.
Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxia or artefact?
Increased postmortem serum mast cell tryptase in a fatal anaphylactoid reaction to nonionic radiocontrast medium.
Inherited and acquired determinants of serum tryptase levels in humans.
Insect sting allergy: new guidelines from the European and USA consensus groups: algorithms and recommendations.
Insect Sting Anaphylaxis-Or Mastocytosis-Or Something Else?
Interactions of human mast cell tryptase with biological protease inhibitors.
Intraoperative anaphylaxis due to aprotinin after local application of fibrin sealant diagnosed by skin tests and basophil activation tests: a case report.
Intraoperative anaphylaxis due to gelofusine in a patient undergoing intramedullary nailing of the femur: a case report.
Is unrecognized anaphylaxis a cause of sudden unexpected death?
Laboratory investigation of deaths due to anaphylaxis.
Late-onset anaphylaxis to fermented soybeans: the first confirmation of food-induced, late-onset anaphylaxis by provocation test.
Latex anaphylaxis causing heart block: role of ranitidine.
Lethal or life-threatening allergic reactions to food.
Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.
Long term safety and immunological effects of a nanobiotherapeutic, bovine poly-[hemoglobin-catalase-superoxide dismutase-carbonic anhydrase], after four weekly 5% blood volume top-loading followed by a challenge of 30% exchange transfusion.
Macrophage engulfment of mucosal mast cells in rats treated with dexamethasone.
Management and Prevention of Anaphylaxis.
Markers of airway inflammation in preschool wheezers.
Markers of anaphylaxis - a systematic review.
Markers of mast cell degranulation.
Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients.
Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases.
Mast cell protease release and mucosal ultrastructure during intestinal anaphylaxis in the rat.
Mast cell tryptase and carboxypeptidase A expression in body fluid and gastrointestinal tract associated with drug-related fatal anaphylaxis.
Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure.
Mast cell tryptase in anaesthetic anaphylactoid reactions.
Mast cell tryptase: a review of its physiology and clinical significance.
Mast cells in cutaneous mastocytosis: accumulation of the MCTC type.
Mastocytosis and insect venom allergy.
Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels.
Matriptase expression in the normal and neoplastic mast cells.
Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells.
Mediator-Related Symptoms and Anaphylaxis in Children with Mastocytosis.
Mediators of anaphylactic reactions: Tryptase and histamine stability in whole blood.
Multi-centre retrospective analysis of anaphylaxis during general anaesthesia in the United Kingdom: aetiology and diagnostic performance of acute serum tryptase.
Multiple bee stings, peritumoral mast cell degranulation and anaphylaxis--is there a relationship?
My patient is allergic to eggs, can i use propofol? A case report and review.
Neuromuscular blocking agents induced anaphylaxis: Results and trends of a French pharmacovigilance survey from 2000 to 2012.
Neutrophil activation during acute human anaphylaxis: analysis of MPO and sCD62L.
No long-lasting or intermittent mast cell activation in acute coronary syndromes.
Over- and underestimated parameters in severe Hymenoptera venom-induced anaphylaxis: Cardiovascular medication and absence of urticaria/angioedema.
Paired acute-baseline serum tryptase levels in perioperative anaphylaxis: an observational study 97/100.
Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology.
Peri-Operative Anaphylaxis-An Investigational Challenge.
Perioperative anaphylactic reactions: Review and procedure protocol in paediatrics.
Persistent anaphylactic reaction after induction with thiopentone and cisatracurium.
Phenotype and risk factors of venom-induced anaphylaxis: A case-control study of the European Anaphylaxis Registry.
Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis.
Possibilities of post-mortem diagnostics, including immunodiagnostics, in cases of sudden death due to anaphylactic and anaphylactoid reactions.
Possible circadian variation of serum mast cell tryptase concentration.
Post mortem tryptase cut-off level for anaphylactic death.
Post mortem tryptase: A review of literature on its use, sampling and interpretation in the investigation of fatal anaphylaxis.
Postmortem diagnosis of acute anaphylaxis by serum tryptase analysis. A case report.
Postmortem diagnosis of anaphylaxis in presence of decompositional changes.
Postmortem Serum Tryptase Levels with Special Regard to Acute Cardiac Deaths.
Postmortem tryptase cutoff points and main causes of fatal anaphylaxis.
Postmortem Tryptase Level in 120 Consecutive Nonanaphylactic Deaths: Establishing a Reference Range as <23 ?g/L.
Predictors of severe anaphylaxis in Hymenoptera venom allergy: The importance of absence of urticaria and angioedema.
Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity.
Primary care management of anaphylaxis.
Prolonged elevation of serum tryptase in idiopathic anaphylaxis.
Prospective evaluation of the diagnostic value of sensitive KIT D816V mutation analysis of blood in adults with suspected systemic mastocytosis.
Raised tryptase without anaphylaxis or mastocytosis: heterophilic antibody interference in the serum tryptase assay.
Recognition and treatment of anaphylaxis.
Recommendations for the Use of Tryptase in the Diagnosis of Anaphylaxis and Clonal Mastcell Disorders.
Refractory anaphylactic cardiac arrest after succinylcholine administration.
Refractory anaphylactic shock associated with ketoconazole treatment.
Remimazolam anaphylaxis during anesthesia induction.
Repeated episodes of anaphylaxis with normal serum tryptase but elevated levels of urinary prostaglandin d2.
Risk assessment in anaphylaxis: current and future approaches.
Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis.
Risk factors and indicators of severe systemic insect sting reactions.
Risk factors in Hymenoptera venom allergy.
Rocuronium: high risk for anaphylaxis?
Role of clinical laboratory in allergy testing.
Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone.
Screening for mast cell tryptase and serum IgE antibodies in 18 patients with anaphylactic shock during general anaesthesia.
Serum basal tryptase levels in healthy children: correlation between age and gender.
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy.
Serum Baseline Tryptase Level as a Marker for the Severity of Anaphylaxis.
Serum mast cell tryptase measurements: Sensitivity and specificity for a diagnosis of anaphylaxis in emergency department patients with shock or hypoxaemia.
Serum Tryptase Cannot Differentiate Vancomycin-Induced Anaphylaxis From Red Man Syndrome.
Serum tryptase in idiopathic anaphylaxis: a case report and review of the literature.
Serum tryptase levels in adverse drug reactions.
Serum tryptase levels in sudden infant death syndrome in forensic autopsy cases.
Serum tryptase measurement in diagnosis of intraoperative anaphylaxis caused by hydatid cyst.
Serum tryptase: an indicator of anaphylaxis following fluorescein angiography.
Severe anaphylaxis to hymenoptera stings: does the basal serum tryptase concentration really matter?
Severe immediate type hypersensitivity reactions in 105 German adults: when to diagnose anaphylaxis.
Stress-induced attenuation of brain stem activation following intestinal anaphylaxis in the rat.
Sudden bronchospasm on intubation: latex anaphylaxis?
Sudden cardiac arrest during cesarean section -- a possible case of amniotic fluid embolism.
Sugammadex hypersensitivity-a case of anaphylaxis.
Systematic follow-up increases incidence of anaphylaxis during adverse reactions in anesthetized patients.
Systemic mastocytosis presenting as intraoperative anaphylaxis with atypical features: a report of two cases.
Systemic reactions and anaphylaxis with an acute serum tryptase ?14 ?g/L: retrospective characterisation of aetiology, severity and adherence to National Institute of Health and Care Excellence (NICE) guidelines for serial tryptase measurements and specialist referral.
Teicoplanin allergy - an emerging problem in the anaesthetic allergy clinic.
Teicoplanin anaphylaxis associated with surgical prophylaxis.
The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis.
The anaphylaxis hypothesis of sudden infant death syndrome (SIDS): mast cell degranulation in cot death revealed by elevated concentrations of tryptase in serum.
The diagnosis of amniotic fluid embolism: an immunohistochemical study for the quantification of pulmonary mast cell tryptase.
The diagnosis of fatal anaphylactic reactions during anaesthesia: employment of immunoassays for mast cell tryptase and drug-reactive IgE antibodies.
The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis.
The effects of different sampling techniques on peripheral post mortem tryptase levels: a recommended sampling method.
The problem of anaphylaxis and mastocytosis.
The significance of diagnosing associated clonal mast cell diseases in patients with venom-induced anaphylaxis and the role of bone marrow investigation.
The significance of post mortem tryptase levels in supporting a diagnosis of anaphylaxis.
The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma.
The utility of serum tryptase in the diagnosis of food-induced anaphylaxis.
The utility of the World Health Organization-The Uppsala Monitoring Centre (WHO-UMC) system for the assessment of adverse drug reactions in hospitalized children.
Three cases of suspected hyperthermia with remarkable elevation of serum mast cell tryptase.
Thrombocytopenia and anaphylaxis secondary to heparin in a hemodialysis patient.
Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis.
Tryptase genetics and anaphylaxis.
Tryptase in anaphylaxis.
Tryptase in diagnosing adverse suspected anaphylactic reaction.
Tryptase Increase without Mastocytosis or Anaphylaxis.
Tryptase levels after suxamethonium administration and defibrillation.
Tryptase levels are not increased during vancomycin-induced anaphylactoid reactions.
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Tryptase levels in children presenting with anaphylaxis: Temporal trends and associated factors.
Tryptase values in anaphylaxis and insect allergy.
Tryptase, a biomarker to support the clinical diagnosis of anaphylaxis.
Tryptase, a mediator of human mast cells.
Tryptase: a clinical indicator of mast cell-dependent events.
Tween-80 and impurity induce anaphylactoid reaction in zebrafish.
Two cases of elevated tryptase in abdominal aortic aneurysm.
Ulcerative colitis patients with an inflammatory response upon mesalazine cannot be desensitized: a randomized study.
Use and Interpretation of Acute and Baseline Tryptase in Perioperative Hypersensitivity and Anaphylaxis.
Use of enoximone in management of anaphylaxis complicated by labetalol use.
Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients.
Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis.
Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis.
Usefulness of UniCAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis.
Using Baseline and Peak Serum Tryptase Levels to Diagnose Anaphylaxis: a Review.
Utilization of serum tryptase and immunoglobulin e assay in the postmortem diagnosis of anaphylaxis.
Validation of international consensus equation for acute serum total tryptase in mast cell activation: A perioperative perspective.
Venom immunotherapy in patients with mastocytosis and hymenoptera venom anaphylaxis.
[A case of anesthesia for laparoscopic cholecystectomy in a patient with a history of frequent anaphylaxis].
[A case report. Tryptase in serum indicated latex-induced anaphylaxis]
[Allergic immunobiology and anesthesiology]
[Anaphylactic and anaphylactoid reactions occurring during anaesthesia in France. Seventh epidemiologic survey (January 2001-December 2002)]
[Anaphylactic reaction as a side-effect of administration of general anesthetics and neuromuscular blocking agents]
[Anaphylactic reaction to thiopental. A case documented by tryptase values and RAST]
[Anaphylactic reaction versus carcinoid crisis: the role of octreotide as a vasoconstrictor]
[Anaphylactoid reactions and late skin reactions to iodinated contrast media: present state of the question--idea development]
[Anaphylaxis after rocuronium: advantage of blood tests for early diagnosis]
[Anaphylaxis sugammadex-induced in a pediatric patient].
[Application of serum total IgE, tryptase and chymase in the identification of death caused by drug anaphylactic shock].
[Biochemical indicators of anaphylactic shock and the application in forensic medicine].
[Changes of Serum IgE and Tryptase in Anaphylactic Shock Rats].
[Comparison of the levels of histamine, tryptase, and interleukin-6 for the investigation of anaphylactoid drug reactions]
[Drug allergy]
[Establishment of new evaluation standards for systemic anaphylactoid reactions using mouse model].
[Expression of tryptase and chymase in human lung tissue of anaphylactic shock]
[Fatal ewe's milk-induced anaphylaxis: laboratory work-up]
[How to diagnose food allergy or the importance of the underestimation of food allergy]
[Importance of plasma (histamine and tryptase) and urinary (methylhistamine) in peri-anesthetic anaphylactic and/or anaphylactoid reactions]
[Importance of the urinary leukotriene E4 level. Preliminary study]
[Intraoperative anaphylactic shock during renal transplantation]
[Management of acute anaphylaxis in clinical practice in the context of the guidelines].
[Mast cell activation syndrome. About a clinical case].
[Mastocytosis: when should it be considered?]
[New variants of diagnostic procedures and therapeutic methods in insect venom allergy]
[Predisposition to latex allergy undetected on preoperative evaluation: a case report].
[Present study on the forensic medicine diagnosis of the sudden erethistic death]
[Pulmonary oedema subsequent to radiographic contrast in a computed tomography of the coronary arteries].
[Quantification of blood levels of tryptase in the diagnosis of anaphylaxis]
[Serum tryptase: marker of occupational anaphylaxis]
[Severe anaphylactic reaction to metamizol during subarachnoid anesthesia]
[The changes of tryptase activity in anaphylactic shock guinea-pigs]
[The improvement of mixed human serum-induced anaphylactic reaction death model in guinea pigs].
[The role of tryptase assay in recognition of anaphylactic reaction to muscle relaxants]
[Tryptase and fatal anaphylaxic reaction]
[Tryptase: A practical guide for the physician].
[Unclear intraoperative cardiorespiratory decompensation. Anaphylactic reaction?]
[Usefulness of measurement of mast cell tryptase for differential diagnosis of anaphylaxis and anaphylactoid reaction]
Anemia
A case of 'smouldering' mastocytosis with high mast cell burden, monoclonal myeloid cells, and C-KIT mutation Asp-816-Val.
Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis.
Serum tryptase measurements in patients with myelodysplastic syndromes.
Systemic Mastocytosis Associated with "Smoldering" Multiple Myeloma.
Aneurysm
Two cases of elevated tryptase in abdominal aortic aneurysm.
Aneurysm, Dissecting
Postmortem Serum Tryptase Levels with Special Regard to Acute Cardiac Deaths.
Angina, Stable
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population.
Angina, Unstable
No long-lasting or intermittent mast cell activation in acute coronary syndromes.
[Tryptase levels are elevated during spontaneous ischemic episodes in unstable angina but not after the ergonovine test in variant angina]
Angioedema
Acquired angioedema with raised serum tryptase.
Good vibrations: Itch induction by whole body vibration exercise without the need of a pruritogen.
Hymenoptera Anaphylaxis and C-kit Mutations: An Unexpected Association.
Predictors of severe anaphylaxis in Hymenoptera venom allergy: The importance of absence of urticaria and angioedema.
Serial measurement of serum tryptase in angiotensin-converting enzyme inhibitor-associated angioedema.
Usefulness of UniCAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis.
Angioedemas, Hereditary
Evidence for bradykinin release in chronic spontaneous urticaria.
Aortic Aneurysm, Abdominal
Mast Cell Chymase and Tryptase in Abdominal Aortic Aneurysm Formation.
Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Two cases of elevated tryptase in abdominal aortic aneurysm.
Aortic Valve Stenosis
Tryptase as a marker of severity of aortic valve stenosis.
Appendicitis
Neuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis: Diagnostic study.
Systemic mastocytosis presenting as acute appendicitis: a case report and review of the literature.
Arrhythmias, Cardiac
High serum tryptase value in massive acute myocardial infarction with ventricular arrhythmia exortion in a cocaine abuser.
Arthralgia
Elevated Tryptase in EoE Is an Independent Phenomenon Associated with Extra-Esophageal Symptoms.
Arthritis
Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.
Leukocyte populations in interstitial cystitis and idiopathic reduced bladder storage.
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid.
Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogens.
Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.
Preliminary study of the tryptase levels in the synovial fluid of patients with inflammatory arthritis.
Protease-activated receptor 2 mediates the proinflammatory effects of synovial mast cells.
Role of mast cells in the induction of dry skin in a mouse model of rheumatoid arthritis.
Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1).
The activation of synovial mast cells: modulation of histamine release by tryptase and chymase and their inhibitors.
The anti-allergic compound tranilast attenuates inflammation and inhibits bone destruction in collagen-induced arthritis in mice.
The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis.
Arthritis, Experimental
[Effects of acupuncture on the number and degranulation ratio of mast cells and expression of tryptase in synovium of rats with adjuvant arthritis]
Arthritis, Psoriatic
Possible molecular mechanisms to account for the involvement of tryptase in the pathogenesis of psoriasis.
Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress.
Arthritis, Reactive
Preliminary study of the tryptase levels in the synovial fluid of patients with inflammatory arthritis.
Arthritis, Rheumatoid
Cellular activation products in osteoarthritis synovial fluid.
Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis.
Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study.
Human mast cell beta-tryptase is a gelatinase.
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid.
Mast cell responses in rheumatoid synovium. Association of the MCTC subset with matrix turnover and clinical progression.
Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.
Preliminary study of the tryptase levels in the synovial fluid of patients with inflammatory arthritis.
Release of mast cell mediators and nitrites into knee joint fluid in osteoarthritis--comparison with articular chondrocalcinosis and rheumatoid arthritis.
Serum Levels of Tryptase Suggest That Mast Cells Might Have an Antiinflammatory Role in Rheumatoid Arthritis: Comment on the Article by Rivellese et al.
Structure of the complex of leech-derived tryptase inhibitor (LDTI) with trypsin and modeling of the LDTI-tryptase system.
Tryptase is a candidate autoantigen in rheumatoid arthritis.
[Tryptase inhibits cell apoptosis through upregulating PAR-2 and Rho kinase in rheumatoid arthritis synovial fibroblasts].
Asthma
A natural product biflavonoid scaffold with anti-tryptase activity.
Activation of pulmonary mast cells by bronchoalveolar allergen challenge. In vivo release of histamine and tryptase in atopic subjects with and without asthma.
Airway Mast Cells in a Rhesus Model of Childhood Allergic Airways Disease.
Airway mast-cell activation in asthmatics is associated with selective sputum eosinophilia.
Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma.
Altered Expression of IFN-?2 in Allergic Airway Disorders and Identification of Its Cell Origins.
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Analysis of sputum taken from wheezy and asthmatic infants and children, with special reference to respiratory infections.
Asthma, bronchial hyperreactivity and mediator release in children with birch pollinosis. ECP and EPX levels are not related to bronchial hyperreactivity.
Bivalent inhibition of human beta-tryptase.
Blood tryptase and thymic stromal lymphopoietin levels predict the risk of exacerbation in severe asthma.
Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum.
Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.
Correlation of bronchial eosinophil and mast cell activation with bronchial hyperresponsiveness in children with asthma.
Correlation of IL-18 with Tryptase in Atopic Asthma and Induction of Mast Cell Accumulation by IL-18.
Cyclotheonamide E4 and E5, new potent tryptase inhibitors from an Ircinia species of sponge.
Degradation of airway neuropeptides by human lung tryptase.
Determinants of serum tryptase in a general population: the relationship of serum tryptase to obesity and asthma.
Development of a specific immunoassay to selectively measure active tryptase in airway samples.
Diagnosis and management of anaphylaxis in precision medicine.
Diagnostic Value of Serum Baseline Tryptase Levels in Childhood Asthma and Its Correlation with Disease Severity.
Direct effects of mast cell proteases, tryptase and chymase, on bronchial epithelial integrity proteins and anti-viral responses.
Direct evidence for a role of the mast cell in the nasal response to aspirin in aspirin-sensitive asthma.
Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates.
Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis.
Effect of current exposure to Der p 1 on asthma symptoms, airway inflammation, and bronchial hyperresponsiveness in mite-allergic asthmatics.
Effect of endosinusal treatment on cellular markers in mild and moderate asthmatics.
Elevated Tryptase in EoE Is an Independent Phenomenon Associated with Extra-Esophageal Symptoms.
Engineered cystine knot miniproteins as potent inhibitors of human mast cell tryptase beta.
Eosinophil cationic protein (ECP), histamine and tryptase in peripheral blood before and during inhalation challenge with toluene diisocyanate (TDI) in sensitized subjects.
Eosinophil cationic protein, myeloperoxidase and tryptase in children with asthma and atopic dermatitis.
Eosinophil-mast cell interaction: Mepolizumab leads to a reduction of clinical symptoms and serum tryptase in a patient with eosinophilic asthma and idiopathic mast cell activation.
Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway.
Expression and characterization of recombinant mast cell tryptase.
Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.
Expression of Inflammatory Mediators in Induced Sputum: Comparative Study in Asthma and COPD.
Factors predicting anaphylaxis in children with tree nut allergies.
Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5.
Genetic factors account for most of the variation in serum tryptase-a twin study.
Granulocyte proteins in serum in childhood asthma: relation to spirometry and therapy.
Histamine and tryptase modulate asthmatic airway smooth muscle GM-CSF and RANTES release.
Histidines are critical for heparin-dependent activation of mast cell tryptase.
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
Human Lung Mast Cell Products Regulate Airway Smooth Muscle CXCL10 Levels.
Identification of basophils by immunohistochemistry in the airways of post-mortem cases of fatal asthma.
Identification of risk factors of severe hypersensitivity reactions in general anaesthesia.
Implications of prostaglandin D2 and leukotrienes in exhaled breath condensates of asthma.
Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxia or artefact?
Inhaled salmeterol and albuterol in asthmatic patients receiving high-dose inhaled corticosteroids.
Inhibition of allergen-induced pulmonary responses by the selective tryptase inhibitor 1,5-bis-[4-[(3-carbamimidoyl-benzenesulfonylamino)-methyl]-phenoxy]-pen tane (AMG-126737).
Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma.
Inhibitors of mast cell tryptase beta as therapeutics for the treatment of asthma and inflammatory disorders.
Inhibitors of tryptase for the treatment of mast cell-mediated diseases.
KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma.
Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep.
Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial.
Mast cell number, phenotype, and function in human pulmonary arterial hypertension.
Mast cell peptidases: chameleons of innate immunity and host defense.
Mast cell tryptase and asthma.
Mast cell tryptase beta as a target in allergic inflammation: an evolving story.
Mast cell tryptase causes homologous desensitization of beta-adrenoceptors by Ca2+ sensitization in tracheal smooth muscle.
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2.
Mast cell tryptase, a still enigmatic enzyme.
Mast cell tryptase: a new target for therapeutic intervention in asthma.
Mast Cell-Mediated Orchestration of the Immune Responses in Human Allergic Asthma: Current Insights.
Mast cells, their subtypes, and relation to asthma phenotypes.
Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma.
Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.
Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprotein efflux.
Occupational asthma and rhinitis due to glutaraldehyde: changes in nasal lavage fluid after specific inhalatory challenge test.
Plasma protein leakage and local secretion of proteins assessed in sputum in asthma and COPD. The effect of inhaled corticosteroids.
Postmortem serum levels of IgE and mast cell tryptase in fatal asthma.
Postmortem serum levels of tryptase and total and specific IgE in fatal asthma.
Potent selective nonpeptidic inhibitors of human lung tryptase.
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives.
Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway.
Protease-activated receptor-2 (PAR2) in the airways.
Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways.
Pulmonary periarterial inflammation in fatal asthma.
Purification and characterization of mast cell tryptase and chymase from human tissues.
Purine derivatives in the study of allergic inflammation in respiratory diseases.
Pyrrole carboxamidine tryptase inhibitors from Leptonychia pubescens.
Repeated ozone exposures enhance bronchial allergen responses in subjects with rhinitis or asthma.
RNA interference decreases PAR-2 expression and function in human airway smooth muscle cells.
Rock, Paper, Scissors: Harnessing Complementarity in Ortholog Detection Methods Improves Comparative Genomic Inference.
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
Serum B12 tryptase level as a marker of allergic airway inflammation in asthma.
Sputum mast cell/basophil gene expression relates to inflammatory and clinical features of severe asthma.
Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
Structure of the complex of leech-derived tryptase inhibitor (LDTI) with trypsin and modeling of the LDTI-tryptase system.
Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase.
Synthesis and evaluation of 4-substituted benzylamine derivatives as beta-tryptase inhibitors.
Synthesis of potent and highly selective inhibitors of human tryptase.
Synthesis of potent and selective 2-azepanone inhibitors of human tryptase.
The relationship between airways inflammation and asthma severity.
The tryptase inhibitor APC-366 reduces the acute airway response to allergen in pigs sensitized to Ascaris suum.
Therapeutic potential of the Peptide leucine arginine as a new nonplant bowman-birk-like serine protease inhibitor.
Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes.
Tryptase activates TGFbeta in human airway smooth muscle cells via direct proteolysis.
Tryptase and histamine release during aspirin-induced respiratory reactions.
Tryptase as an inflammatory marker in allergic disease and asthma.
Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells.
Tryptase inhibition blocks airway inflammation in a mouse asthma model.
Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.
Tryptase inhibitors: a novel class of anti-inflammatory drugs.
Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi.
Tryptase, a mediator of human mast cells.
Tryptase-induced airway microvascular leakage in guinea pigs: involvement of tachykinins and leukotrienes.
Unique Effect of Aspirin Therapy on Biomarkers in Aspirin-exacerbated Respiratory Disease. A Prospective Trial.
Venom Immunotherapy in High-Risk Patients: The Advantage of the Rush Build-Up Protocol.
Asthma, Exercise-Induced
Changes in blood levels of eosinophil cationic protein and tryptase after exercise challenge in adolescents with exercise-induced asthma.
Asthma, Occupational
Occupational asthma and rhinitis due to glutaraldehyde: changes in nasal lavage fluid after specific inhalatory challenge test.
Atherosclerosis
Circulating tryptase as a marker for subclinical atherosclerosis in obese subjects.
Mast cell tryptase degrades HDL and blocks its function as an acceptor of cellular cholesterol.
Mast cells of two types differing in neutral protease composition in the human aortic intima. Demonstration of tryptase- and tryptase/chymase-containing mast cells in normal intimas, fatty streaks, and the shoulder region of atheromas.
Morphological and histopathological study of autopsied patients with atherosclerosis and HIV.
Postmortem IgE determination in coronary artery disease.
Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases.
Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice.
Tryptase promotes human monocyte-derived macrophage foam cell formation by suppressing LXRalpha activation.
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population.
Utilization of serum tryptase and immunoglobulin e assay in the postmortem diagnosis of anaphylaxis.
Atrial Fibrillation
Tryptase levels after suxamethonium administration and defibrillation.
Autoimmune Diseases
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Azoospermia
Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells.
Significance of human testicular mast cells and their subtypes in male infertility.
Bacterial Infections
Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung.
The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.
Barrett Esophagus
Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia.
Bile Reflux
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Blister
Activation of Cutaneous Immune Responses in Complex Regional Pain Syndrome.
Clinical aspects of paediatric mastocytosis: a review of 101 cases.
Gene expression profiling in dermatitis herpetiformis skin lesions.
IgE-Mediated Hypersensitivity: Patients with Complex Regional Pain Syndrome Type 1 (CRPS1) vs the Dutch Population. A Retrospective Study.
Increased tryptase and myeloperoxidase levels in blister fluids of patients with bullous pemphigoid: correlations with cytokines, adhesion molecules and anti-basement membrane zone antibodies.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase.
Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1.
Release of histamine and tryptase in vivo after prolonged cutaneous challenge with allergen in humans.
Release of soluble tryptase but only minor amounts of chymase activity from cutaneous mast cells.
Tryptase concentration in skin blister fluid from patients with bullous skin conditions.
Bone Diseases, Metabolic
Clinical aspects of paediatric mastocytosis: a review of 101 cases.
Bone Resorption
Mast cell-derived tryptase in odontogenic cysts.
Brain Edema
Evaluation of mast cells and hypoxia inducible factor-1 expression in meningiomas of various grades in correlation with peritumoral brain edema.
Hydrogen Inhalation Ameliorated Mast Cell-Mediated Brain Injury After Intracerebral Hemorrhage in Mice.
Breast Neoplasms
Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases.
C-Kit receptor and tryptase expressing mast cells correlate with angiogenesis in breast cancer patients.
Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts.
Interplay between Mast Cells and Lymphatic Vessels in Different Molecular Types of Breast Cancer.
Mast cell inhibitor cromolyn increases blood clotting and hypoxia in murine breast cancer.
Mast cell tryptase promotes breast cancer migration and invasion.
Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer.
Mast Cells as an Indicator and Prognostic Marker in Molecular Subtypes of Breast Cancer.
Serum tryptase, mast cells positive to tryptase and microvascular density evaluation in early breast cancer patients: possible translational significance.
Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation.
Tryptase promotes breast cancer angiogenesis through PAR-2 mediated endothelial progenitor cell activation.
Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients.
Bronchial Hyperreactivity
Tryptase, a mediator of human mast cells.
Bronchial Spasm
Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis.
Bronchiectasis
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
Bronchiolitis
Tryptase and IgE concentrations in the respiratory tract of infants with acute bronchiolitis.
Bronchiolitis Obliterans
Mast cells in bronchiolitis obliterans organizing pneumonia. Mast cell hyperplasia and evidence for extracellular release of tryptase.
The potential role of mast cells in lung allograft rejection.
Bronchitis
Inhaled corticosteroids in stable COPD patients: do they have effects on cells and molecular mediators of airway inflammation?
Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2.
[Analysis of tryptase levels in infants and children with wheezy bronchitis]
Bronchopulmonary Dysplasia
Tryptase immunoreactive mast cell hyperplasia in bronchopulmonary dysplasia.
Carcinogenesis
Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2.
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers.
Combined histochemical approach in assessing tryptase expression in the mast cell population.
Serum tryptase levels in melanoma patients: case-control study and review of the literature.
The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix.
Carcinoid Tumor
[Anaphylactic reaction versus carcinoid crisis: the role of octreotide as a vasoconstrictor]
Carcinoma
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers.
Correlation of Mast Cell Densities, Angiogenesis and Vascular Endothelial Growth Factor in Proper Muscle Gastric Carcinomas.
Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis.
Density of mast cells and microvessels in minor salivary gland tumors.
Early effect of boron neutron capture therapy mediated by boronophenylalanine (BPA-BNCT) on mast cells in premalignant tissue and tumors of the hamster cheek pouch.
High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2.
Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma.
Increase of endo-peptidases and exo-peptidases in thyroid-tumors.
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
Intensity of angiogenesis and mast cell infiltration in cervical intraepithelial and invasive lesions - are they correlated?
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro.
Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.
Mast Cells and Proteins Related to Myofibroblast Differentiation (PAR-2, IL-6, and TGF?1) in Salivary Cancers: A Preliminary Study.
Mast cells correlate with angiogenesis and poor outcome in stage I lung adenocarcinoma.
Mast cells have prognostic value in Merkel cell carcinoma.
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Potential role of mast cells in hamster cheek pouch carcinogenesis.
Serum level of mast cell tryptase in patients with oral squamous cell carcinoma: lack of correlation with clinicopathologic factors.
Stimulation of protease activated receptors on RT4 cells mediates arachidonic acid release via Ca2+ independent phospholipase A2.
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
Tumor-infiltrating mast cells predict prognosis and gemcitabine-based adjuvant chemotherapeutic benefit in biliary tract cancer patients.
Carcinoma, Adenoid Cystic
Density of mast cells and microvessels in minor salivary gland tumors.
Mast Cells and Proteins Related to Myofibroblast Differentiation (PAR-2, IL-6, and TGF?1) in Salivary Cancers: A Preliminary Study.
Carcinoma, Bronchogenic
Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease.
Carcinoma, Embryonal
Introduction of a human X-6 translocation chromosome into a mouse teratocarcinoma: investigation of control of HLA-A, B, C expression.
Carcinoma, Hepatocellular
Mast cells positive to tryptase, endothelial cells positive to protease-activated receptor-2, and microvascular density correlate among themselves in hepatocellular carcinoma patients who have undergone surgery.
Tryptase serum levels in patients suffering from hepatocellular carcinoma undergoing intra-arterial chemoembolization: Possible predictive role of response to treatment.
Carcinoma, Mucoepidermoid
Density of mast cells and microvessels in minor salivary gland tumors.
Mast Cells and Proteins Related to Myofibroblast Differentiation (PAR-2, IL-6, and TGF?1) in Salivary Cancers: A Preliminary Study.
Carcinoma, Pancreatic Ductal
Mast cells and angiogenesis in pancreatic ductal adenocarcinoma.
Carcinoma, Renal Cell
High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2.
Carcinoma, Squamous Cell
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers.
Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis.
Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro.
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
The increase in tryptase- and chymase-positive mast cells is associated with partial inactivation of chymase and increase in protease inhibitors in basal cell carcinoma.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
Cardiomyopathies
Comparison of effects of ioxaglate versus iomeprol on histamine and tryptase release in patients with ischemic cardiomyopathy.
Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure.
Renin: at the heart of the mast cell.
Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy.
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Cardiovascular Diseases
Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old.
Cardiovascular disease and anaphylaxis.
Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases.
Diagnosis of Hymenoptera venom allergy.
Influence of total and specific IgE, serum tryptase, and age on severity of allergic reactions to Hymenoptera stings.
Mast cell peptidases: chameleons of innate immunity and host defense.
Mast cell tryptase - Marker and maker of cardiovascular diseases.
No long-lasting or intermittent mast cell activation in acute coronary syndromes.
Tryptase inhibitors: a patent review.
Venom Immunotherapy in High-Risk Patients: The Advantage of the Rush Build-Up Protocol.
Celiac Disease
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
[Histochemical and immunohistochemical study of jejunal mucosa cells in children with celiac sprue]
Cerebral Hemorrhage
Hydrogen Inhalation Ameliorated Mast Cell-Mediated Brain Injury After Intracerebral Hemorrhage in Mice.
Cerebrovascular Disorders
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Cheilitis
Actinic cheilitis: Epithelial expression of COX-2 and its association with mast cell tryptase and PAR-2.
Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis.
Increased mast cell density and protease content in actinic cheilitis.
Cholecystitis
Expression of phenotypic markers of mast cells, macrophages and dendritic cells in gallbladder mucosa with calculous cholecystitis.
Cholera
IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum.
Neuronal involvement in the intestinal effects of Clostridium difficile toxin A and Vibrio cholerae enterotoxin in rat ileum.
Cholestasis
KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
Cholesteatoma
Increased numbers of mast cells in human middle ear cholesteatomas: implications for treatment.
Isolation and characterization of trypsin-like and chymotrypsin-like proteinases from human cholesteatoma.
cholinesterase deficiency
Allergic reaction to suxamethonium during emergency caesarean section and pseudocholinesterase deficiency in the same patient.
Chondrocalcinosis
Cellular activation products in osteoarthritis synovial fluid.
Release of mast cell mediators and nitrites into knee joint fluid in osteoarthritis--comparison with articular chondrocalcinosis and rheumatoid arthritis.
Chronic Periodontitis
Tryptase and TIM-1 double-positive mast cells in different stages of human chronic periodontitis.
Chronic Urticaria
Chronic inducible urticaria subtypes in children: Clinical features and prognosis.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Serum total tryptase levels are increased in patients with active chronic urticaria.
The Utility of Serum Tryptase as a Marker in Chronic Spontaneous Urticaria.
Colitis
A Difficult Case of Mastocytic Colitis with Elevated Tryptase.
Basic and translational research on proteinase-activated receptors: implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation.
Essential role for mast cell tryptase in acute experimental colitis.
Importance of mast cell Prss31/transmembrane tryptase/tryptase-? in lung function and experimental chronic obstructive pulmonary disease and colitis.
Induction of tryptase and histamine release from human colon mast cells by IgE dependent or independent mechanisms.
Inhibition of tryptase release from human colon mast cells by protease inhibitors.
Mast cells and inflammatory bowel disease.
Modulation of histamine release from human colon mast cells by protease inhibitors.
Review article: anti-tryptase therapy in inflammatory bowel disease.
[Tryptase activity in colon mucosal samples of children with inflammatory bowel disease]
[When the fluoro-immuno-enzymatic (FEIA) measurements turn out to be more sensitive than radioimmunologic (RIA) measurements. Application to the measurement of serum tryptase]
Colitis, Collagenous
Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis.
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Colitis, Lymphocytic
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Colitis, Ulcerative
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity.
Expression of protease-activated receptor 2 in ulcerative colitis.
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Mast cell peptidases: chameleons of innate immunity and host defense.
Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease.
Review article: anti-tryptase therapy in inflammatory bowel disease.
Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open-label pilot study.
[Tryptase activity in colon mucosal samples of children with inflammatory bowel disease]
Colonic Neoplasms
Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins.
The Effect of Prim-O-Glucosylcimifugin on Tryptase-Induced Intestinal Barrier Dysfunction in Caco-2 Cells.
Colorectal Neoplasms
Effects of analgesic and surgical modality on immune response in colorectal cancer surgery.
Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically.
Mast cells positive to tryptase and tumour-associated macrophages correlate with angiogenesis in locally advanced colorectal cancer patients undergone to surgery.
Complex Regional Pain Syndromes
Activation of Cutaneous Immune Responses in Complex Regional Pain Syndrome.
Substance P Signaling Controls Mast Cell Activation, Degranulation, and Nociceptive Sensitization in a Rat Fracture Model of Complex Regional Pain Syndrome.
Conjunctivitis
Immunophenotyping of human dendriform cells from the conjunctival epithelium.
Inhibitors of tryptase for the treatment of mast cell-mediated diseases.
The level of tryptase in human tears. An indicator of activation of conjunctival mast cells.
[Release of chemical mediators in the conjunctival lavage fluids after eye provocation with allergen or compound 48/80]
Conjunctivitis, Allergic
Activation of corneal fibroblast-derived matrix metalloproteinase-2 by tryptase.
Efficacy of lodoxamide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis.
Histamine and tryptase levels in allergic conjunctivitis and vernal keratoconjunctivitis.
Hyperexpression of the high-affinity IgE receptor-{beta} chain in chronic allergic keratoconjunctivitis.
Tear chymase in vernal keratoconjunctivitis.
Tear tryptase in vernal keratoconjunctivitis.
Tear tryptase levels and allergic conjunctivitis.
The level of tryptase in human tears. An indicator of activation of conjunctival mast cells.
Tryptase increases proliferative activity of human conjunctival fibroblasts through protease-activated receptor-2.
Contracture
Human serum mast cell tryptase levels in elbow fractures or dislocations and its association with injury severity.
Serum Mast Cell Tryptase as a Marker of Posttraumatic Joint Contracture in a Rabbit Model.
The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures.
Corneal Injuries
Epithelium-derived IL-33 activates mast cells to initiate neutrophil recruitment following corneal injury.
Corneal Ulcer
[Corneal ulcerative lesions in type-I immediate hypersensitivity]
Coronary Artery Disease
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Comparing the Heart-Thigh and Thigh-Ankle Arteries with the Heart-Ankle Arterial Segment for Arterial Stiffness Measurements.
Mast cell tryptase: a new biomarker in patients with stable coronary artery disease.
Mast cells and acute coronary syndromes: relationship between serum tryptase, clinical outcome and severity of coronary artery disease.
Postmortem IgE determination in coronary artery disease.
Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure.
Coronary Disease
Comparison of effects of ioxaglate versus iomeprol on histamine and tryptase release in patients with ischemic cardiomyopathy.
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population.
Coronary Thrombosis
Postmortem IgE determination in coronary artery disease.
Cough
Cough reflex sensitivity and airway inflammation in patients with chronic cough due to non-acid gastro-oesophageal reflux.
Crohn Disease
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Mast cell tryptase in sera of patients with Crohn's disease and mastocytosis.
Phenotypic change and accumulation of smooth muscle cells in strictures in Crohn's disease: relevance to local angiotensin II system.
Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease.
[Tryptase activity in colon mucosal samples of children with inflammatory bowel disease]
[When the fluoro-immuno-enzymatic (FEIA) measurements turn out to be more sensitive than radioimmunologic (RIA) measurements. Application to the measurement of serum tryptase]
Cryptogenic Organizing Pneumonia
Mast cells in bronchiolitis obliterans organizing pneumonia. Mast cell hyperplasia and evidence for extracellular release of tryptase.
Cystic Fibrosis
Mast cell tryptase changes with Aspergillus fumigatus - Host crosstalk in cystic fibrosis patients.
Cystitis
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome.
Cystitis, Interstitial
Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study.
Angiogenesis in bladder tissues is strongly correlated with urinary frequency and bladder pain in patients with interstitial cystitis/bladder pain syndrome.
Elevated mast cell tryptase in the urine of patients with interstitial cystitis.
Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients.
Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation.
Massive extracellular tryptase from activated bladder mast cells in interstitial cystitis.
Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.
Cysts
Mast cell-derived tryptase in odontogenic cysts.
Death, Sudden, Cardiac
Expression of Fc?RI? and tryptase in human lung tissue during drug-induced anaphylactic death.
Dengue
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Association of mast cell-derived VEGF and proteases in dengue shock syndrome.
Dengue virus-elicited tryptase induces endothelial permeability and shock.
Mast cell mediators in relation to dengue severity: A systematic review and meta-analysis.
Secretory phospholipase A2 in the pathogenesis of acute dengue infection.
Dermatitis
Hypersensitivity reactions to ophthalmic products.
Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis.
Mast cells and eosinophils in feline allergic dermatitis: a qualitative and quantitative analysis.
Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis.
Dermatitis Herpetiformis
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Serum eosinophil cationic protein, myeloperoxidase, tryptase, eotaxin and Th2-L-like cytokines in Dermatitis herpetiformis.
Dermatitis, Atopic
Changes in Histamine/Tryptase Levels in Skin Chambers: Application for Clinical Evaluation of Atopic Dermatitis.
Comparison of severity scoring of atopic dermatitis values and serum levels of eosinophil cationic protein and mast cell tryptase for routine evaluation of atopic dermatitis.
Dry skin and impairment of barrier function associated with itch - new insights.
Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels.
Eosinophil cationic protein, myeloperoxidase and tryptase in children with asthma and atopic dermatitis.
Epidermal Expression of Filaggrin/Profilaggrin Is Decreased in Atopic Dermatitis: Reverse Association With Mast Cell Tryptase and IL-6 but Not With Clinical Severity.
Factors that predict disease severity in atopic dermatitis: The role of serum basal tryptase.
Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Itch and eczema.
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase.
Oral antihistamine therapy influences plasma tryptase levels in adult atopic dermatitis.
Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin.
Pruritus and Atopic Dermatitis.
Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis.
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema.
Serum mast cell tryptase is not a useful marker for disease severity in psoriasis or atopic dermatitis.
Serum tryptase and urinary 1-methylhistamine as parameters for monitoring oral food challenges in children.
The presence of tryptase-positive and bikunin-negative mast cells in psoriatic skin lesions.
Tryptase and protease-activated receptor-2 stimulate scratching behavior in a murine model of ovalbumin-induced atopic-like dermatitis.
[Dermal reactions in children with atopic dermatitis--changes in histamine/tryptase levels in skin chambers. Report 1]
Dermatitis, Contact
Hypersensitivity reactions to complementary and alternative medicine products.
Imidazolidinyl urea activates mast cells via MRGPRX2 to induce non-histaminergic allergy.
Dermatofibrosarcoma
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Diabetes Mellitus
Are mast cells important in diabetes?
Diabetes Mellitus, Type 2
Are mast cells important in diabetes?
Diabetic Retinopathy
Involvement of premacular mast cells in the pathogenesis of macular diseases.
Long-term evaluation of spontaneous release of epiretinal membrane and its possible pathogenesis.
The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes.
Disseminated Intravascular Coagulation
Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis.
Drug Hypersensitivity
Basal serum tryptase is not a risk factor for immediate-type drug hypersensitivity during childhood.
Non-allergic nature of docetaxel-induced acute hypersensitivity reactions.
Drug-Related Side Effects and Adverse Reactions
Serum tryptase levels in adverse drug reactions.
Duodenal Ulcer
Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease.
[Alcohol-dependent mast cell activation in ulcer]
Duodenitis
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease.
Dyslipidemias
Anti-Amoxicillin Immunoglobulin E, Histamine-2 Receptor Antagonist Therapy and Mast Cell Activation Syndrome Are Risk Factors for Amoxicillin Anaphylaxis.
Dysplastic Nevus Syndrome
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Echinococcosis
Serum tryptase measurement in diagnosis of intraoperative anaphylaxis caused by hydatid cyst.
Eczema
Elevated levels of tryptase in children with nummular eczema.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Orange-induced skin lesions in patients with atopic eczema: evidence for a non-IgE-mediated mechanism.
Quantitative analysis of tryptase- and chymase-containing mast cells in atopic dermatitis and nummular eczema.
The presence of tryptase-positive and bikunin-negative mast cells in psoriatic skin lesions.
Embolism
A fatal case of amniotic fluid embolism with elevation of serum mast cell tryptase.
Amniotic fluid embolism complicating medical termination of pregnancy.
Amniotic fluid embolism, anaphylaxis, and tryptase.
Ancillary studies in amniotic fluid embolism: a case report and review of the literature.
Complement C3a expression and tryptase degranulation as promising histopathological tests for diagnosing fatal amniotic fluid embolism.
Immunologic studies in presumed amniotic fluid embolism.
Serum tryptase analysis in a woman with amniotic fluid embolism. A case report.
The diagnosis of amniotic fluid embolism: an immunohistochemical study for the quantification of pulmonary mast cell tryptase.
Embolism, Amniotic Fluid
A fatal case of amniotic fluid embolism with elevation of serum mast cell tryptase.
Amniotic fluid embolism complicating medical termination of pregnancy.
Amniotic fluid embolism, anaphylaxis, and tryptase.
Ancillary studies in amniotic fluid embolism: a case report and review of the literature.
Complement C3a expression and tryptase degranulation as promising histopathological tests for diagnosing fatal amniotic fluid embolism.
Immunologic studies in presumed amniotic fluid embolism.
Serum tryptase analysis in a woman with amniotic fluid embolism. A case report.
The diagnosis of amniotic fluid embolism: an immunohistochemical study for the quantification of pulmonary mast cell tryptase.
Encephalitis
Computational identification of natural product leads that inhibit mast cell chymase: an exclusive plausible treatment for Japanese encephalitis.
Encephalitis, Japanese
Computational identification of natural product leads that inhibit mast cell chymase: an exclusive plausible treatment for Japanese encephalitis.
Endometrial Hyperplasia
Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.
Endometrial Neoplasms
Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.
Endometriosis
Current concepts of the pathogenesis of endometriosis.
Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin.
Mast Cells in Peritoneal Fluid From Women With Endometriosis and Their Possible Role in Modulating Sperm Function.
[Sodium cromoglycate attenuates experimental endometriosis in rats by regulating mast cells].
Enteritis
A role of a lymphocyte tryptase, granzyme A, in experimental ulcerative colitis.
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Enterocolitis
Mastocytic enterocolitis: increased mucosal mast cells in chronic intractable diarrhea.
Eosinophilia
Cell infiltration, ICAM-1 expression, and eosinophil chemotactic activity in asthmatic sputum.
Effect of H1 and H2 antagonists on nasal symptoms and mediator release in atopic patients after nasal allergen challenge during the pollen season.
Effects of a reversible beta-tryptase and trypsin inhibitor (RWJ-58643) on nasal allergic responses.
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.
Elevated Tryptase in EoE Is an Independent Phenomenon Associated with Extra-Esophageal Symptoms.
Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease.
Hypereosinophilic syndrome with elevated serum tryptase versus systemic mast cell disease associated with eosinophilia: 2 distinct entities?
In vitro diagnosis of chronic nasal inflammation.
Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome.
Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD.
Systemic mastocytosis (SM) associated with chronic eosinophilic leukemia (SM-CEL): detection of FIP1L1/PDGFRalpha, classification by WHO criteria, and response to therapy with imatinib.
Systemic mastocytosis presenting as acute appendicitis: a case report and review of the literature.
Systemic mastocytosis: bone marrow pathology, classification, and current therapies.
Systemic mastocytosis: current concepts and treatment advances.
Tryptase inhibitors block allergen-induced airway and inflammatory responses in allergic sheep.
[Humoral mucosal immunity in allergic rhinitis]
Eosinophilic Esophagitis
An Increasing Trend of Eosinophilic Esophagitis in Korea and the Clinical Implication of the Biomarkers to Determine Disease Activity and Treatment Response in Eosinophilic Esophagitis.
MAST CELLS DISTINGUISH EOSINOPHILIC ESOPHAGITIS IN PEDIATRIC PATIENTS.
Serum Eosinophil Cationic Protein is Superior to Mast Cell Tryptase as Marker for Response to Topical Corticosteroid Therapy in Eosinophilic Esophagitis.
Tryptase Staining of Mast Cells May Differentiate Eosinophilic Esophagitis from Gastroesophageal Reflux Disease.
Utility of major basic protein, eotaxin-3, and mast cell tryptase staining for prediction of response to topical steroid treatment in eosinophilic esophagitis: analysis of a randomized, double-blind, double dummy clinical trial.
Epiretinal Membrane
Involvement of premacular mast cells in the pathogenesis of macular diseases.
The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes.
Erythema
Acute exposure of human skin to ultraviolet or infrared radiation or heat stimuli increases mast cell numbers and tryptase expression in human skin in vivo.
Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges.
Diffuse cutaneous mastocytosis: Identification of KIT mutation and long-term follow-up with serum tryptase level.
Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia.
Erythema Multiforme
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Esophageal Achalasia
Lower esophageal sphincter muscle of patients with achalasia exhibits profound mast cell degranulation.
Esophagitis, Peptic
MAST CELLS DISTINGUISH EOSINOPHILIC ESOPHAGITIS IN PEDIATRIC PATIENTS.
Ethmoid Sinusitis
Tryptase in nasal fluid is a useful marker of allergic rhinitis.
Exanthema
Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease.
KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
Fibroma
Immunohistochemical expression of mast cell tryptase in giant cell fibroma and inflammatory fibrous hyperplasia of the oral mucosa.
Fibrosarcoma
Gene expression analysis in mastocytosis reveals a highly consistent profile with candidate molecular markers.
Immunohistochemical evaluation of mast cells and mark activity tryptase and chymase in experimental fibrosarcoma.
Food Hypersensitivity
Characterisation of immune mediator release during the immediate response to segmental mucosal challenge in the jejunum of patients with food allergy.
Detection of local mast-cell activity in patients with food hypersensitivity.
Factors that predict disease severity in atopic dermatitis: The role of serum basal tryptase.
Helicobacter pylori as a protective factor against food allergy.
Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study.
In vitro model for IgE mediated food allergy.
Mast Cell Tryptase Levels in Gut Mucosa in Patients with Gastrointestinal Symptoms Caused by Food Allergy.
Patterns of anaphylaxis: acute and late phase features of allergic reactions.
Release of mast cell mediators into the jejunum by cold pain stress in humans.
Release of Mast Cell Tryptase into Saliva: A Tool to Diagnose Food Allergy by a Mucosal Challenge Test?
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy.
Serum tryptase and urinary 1-methylhistamine as parameters for monitoring oral food challenges in children.
TIA1 and mast cell tryptase in food allergy of children: increase of intraepithelial lymphocytes expressing TIA1 associates with allergy.
Time course of plasma histamine and tryptase following food challenges in children with suspected food allergy.
TRYPTASE AND HISTAMINE MAY SUPPORT ORAL FOOD CHALLENGE IN THE DIAGNOSIS OF ALLERGY.
[Determination of the tryptase level as diagnostic marker in food allergy in children]
[Dynamic diagnosis of allergy by the sequential measurement of mediators: apropos of a case of food allergy]
[Usefulness of Pharmacia tryptase test RIACT in diagnosis of IgE-dependent food allergy]
Gastritis
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Gastroenteritis
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Gastroesophageal Reflux
Increased Numbers of Eosinophils, Rather Than Only Etiology, Predict Histologic Changes in Patients With Esophageal Eosinophilia.
Tryptase Staining of Mast Cells May Differentiate Eosinophilic Esophagitis from Gastroesophageal Reflux Disease.
Gastrointestinal Neoplasms
Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically.
Gaucher Disease
Persistent tryptase elevation in a patient with Gaucher disease.
Geographic Atrophy
Mast Cell-Derived Tryptase in Geographic Atrophy.
Gingival Overgrowth
The possible potential therapeutic targets for drug induced gingival overgrowth.
Gingivitis
Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation.
Mast Cells in the Periodontal Disease of Non-HIV-Infected and HIV-Infected Individuals Undergoing Highly Active Antiretroviral Therapy.
Gliosarcoma
Dural and osteolytic sarcomatoid relapse of a secondary gliosarcoma with tryptase immunoreactivity.
Glomerulonephritis
Role of stem cell factor and mast cells in the progression of chronic glomerulonephritides.
Granuloma
Comparative immunohistochemical study of the presence of mast cells in apical granulomas and periapical cysts: possible role of mast cells in the course of human periapical lesions.
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
Heart Arrest
Diagnostic value of histamine and tryptase concentrations in severe anaphylaxis with shock or cardiac arrest during anesthesia.
Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NF?B pathway following asphyxial cardiac arrest in rats.
Pseudoanaphylaxis.
Refractory anaphylactic cardiac arrest after succinylcholine administration.
Heart Diseases
Changes in the number of mast cells, expression of fibroblast growth factor-2 and extent of interstitial fibrosis in established and advanced hypertensive heart disease.
Expressions of Mast Cell Tryptase and Brain Natriuretic Peptide in Myocardium of Sudden Death due to Hypersensitivity and Coronary Atherosclerotic Heart Disease.
Rock, Paper, Scissors: Harnessing Complementarity in Ortholog Detection Methods Improves Comparative Genomic Inference.
Heart Failure
Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis.
Relation of serum levels of mast cell tryptase of left ventricular systolic function, left ventricular volume or congestive heart failure.
Hemangioendothelioma
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
Hemangioma
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
Mast cells and hemangioma.
Mast cells are a major source of basic fibroblast growth factor in chronic inflammation and cutaneous hemangioma.
Hemangioma, Capillary
Involvement of mast cells and microvessels density in reactive lesions of oral cavity: A comparative immunohistochemical study.
Hemangioma, Cavernous
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
Hemangiosarcoma
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Hematologic Neoplasms
Mastocytosis onset in a patient with treated hairy cell leukemia: Just a coincidence?
Systemic mastocytosis: bone marrow pathology, classification, and current therapies.
Hepatitis B
Interaction of hepatitis B virus X protein with a serine protease, tryptase TL2 as an inhibitor.
Hepatitis B, Chronic
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Hepatitis C
High bone mass in adults.
Hepatitis C, Chronic
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Hepatitis, Autoimmune
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Hepatomegaly
Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial.
Mast Cell Leukemia with Ascites and Multiple Organs Damage.
Treatment of three patients with systemic mastocytosis with interferon alpha-2b.
Herpes Zoster
Sini San ameliorates duodenal mucosal barrier injury and low?grade inflammation via the CRF pathway in a rat model of functional dyspepsia.
Urothelial Barrier Deficits, Suburothelial Inflammation and Altered Sensory Protein Expressions in Detrusor Underactivity.
Histiocytoma
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Histiocytosis
Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD.
HIV Infections
T-cell membrane-associated serine protease, tryptase TL2, binds human immunodeficiency virus type 1 gp120 and cleaves the third-variable-domain loop of gp120. Neutralizing antibodies of human immunodeficiency virus type 1 inhibit cleavage of gp120.
Hodgkin Disease
Expression of mast cell tryptases in Hodgkin and Reed-Sternberg (HRS) cells.
[Tryptase- and chymase-positive mast cells as possible prognostic factor in patients with Hodgkin's lymphoma]
Hyperalgesia
Downregulation of iNOS, IL-1?, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats.
Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia.
Protease-activated receptors in the Achilles tendon-a potential explanation for the excessive pain signalling in tendinopathy.
TRPA1 in Mast Cell Activation-induced Long-lasting Mechanical Hypersensitivity of Vagal Afferent C fibers in Guinea Pig Esophagus.
Hypercholesterolemia
Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old.
Hyperemia
Protease-activated receptor 2 mediates the proinflammatory effects of synovial mast cells.
Hypereosinophilic Syndrome
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.
Hypereosinophilic syndrome with elevated serum tryptase versus systemic mast cell disease associated with eosinophilia: 2 distinct entities?
Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome.
Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome.
Systemic mastocytosis: bone marrow pathology, classification, and current therapies.
The serum tryptase test: an emerging robust biomarker in clinical hematology.
Hyperlipidemias
Large Accumulation of Collagen and Increased Activation of Mast Cells in Hearts of Mice with Hyperlipidemia.
Hyperlipoproteinemia Type II
Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia.
Hypersensitivity
A case report: anaphylaxis to cefazolin?during?renal?transplant?surgery.
A confirmed case of sugammadex-induced anaphylaxis in a UK hospital.
Active monomers of human beta-tryptase have expanded substrate specificities.
Acute coronary syndrome secondary to clarithromycin: the first case and review of the literature.
Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Adherence to recommended UK sampling protocols for detecting mast cell mediator release in perioperative anaphylaxis.
Allergen challenge-induced entry of alpha 2-macroglobulin and tryptase into human nasal and bronchial airways.
Allergy and allergic mediators in tears.
An anaphylactic reaction to blood supplied from patient's mother.
An increase in serum tryptase even below 11.4 ng/mL may indicate a mast cell-mediated hypersensitivity reaction: a prospective study in Hymenoptera venom allergic patients.
Anaesthetic hypersensitivity reactions in France between 2011 and 2012: the 10th GERAP epidemiologic survey.
Analysis and characteristics of mast cell tryptase and eosinophilic cationic protein from human gut mucosa in gastrointestinal allergy.
Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients.
Anaphylactic reaction with hydroxyethyl starch during anesthesia - A case report.
Anaphylactic Reactions to Native and Light-Exposed Sugammadex Suggested by Basophil Activation Test: A Report of 2 Cases.
Anaphylactoid shock--a common cause of death in heroin addicts?
Anaphylaxis and Clinical Utility of Real-World Measurement of Acute Serum Tryptase in UK Emergency Departments.
Anaphylaxis to goat/sheep's milk in a 4-year-old boy tolerant to cow's milk.
Anaphylaxis to Patent Blue V: a case series.
Anti-inflammatory and antiallergic effects of ketorolac tromethamine in the conjunctival provocation model.
Antiallergic actions of high topical doses of terbutaline in human nasal airways.
Assessment of immunologic mechanisms for flare reactions to Synvisc.
Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly.
Basal serum tryptase is not a risk factor for immediate-type drug hypersensitivity during childhood.
Basal serum tryptase level correlates with severity of hymenoptera sting and age.
Baseline Serum Tryptase Levels and Adverse Reactions to Injection Specific Immunotherapy with Airborne Allergens: Is There a Relationship?
Biochemical markers of anaphylactoid reactions to drugs. Comparison of plasma histamine and tryptase.
Case report: Intraoperative anaphylactoid reaction and hydroxyethyl starch in balanced electrolyte solution (Hextend(R)): [Presentation de cas : reaction anaphylactoide peroperatoire et amidon hydroxyethyle dans une solution d'electrolyte balancee (Hextend(R))].
Characteristics and Treatment of Anaphylaxis in Children Visiting a Pediatric Emergency Department in Korea.
Clinical laboratory assessment of immediate-type hypersensitivity.
Clonal mast cell disorders in patients with severe Hymenoptera venom allergy and normal serum tryptase levels.
Cloning of the human homolog of mouse transmembrane tryptase.
Comparison of Basophil Activation Test and Skin Testing Performances in NMBA Allergy.
Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings.
Determination of inflammatory markers in allergic reactions to drugs.
Diagnostic value of histamine and tryptase concentrations in severe anaphylaxis with shock or cardiac arrest during anesthesia.
Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges.
Downregulation of iNOS, IL-1?, and P2X7 Expression in Mast Cells via Activation of PAR4 Contributes to the Inhibition of Visceral Hyperalgesia in Rats.
Drug-induced angioedema.
Effect of general anesthesia and orthopedic surgery on serum tryptase.
Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy.
Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review.
Elevated serum tryptase level in a case of intraoperative anaphylaxis caused by latex allergy.
Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis.
Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children.
Expression of mast cell tryptase in pediatric otitis media with effusion.
Expressions of Mast Cell Tryptase and Brain Natriuretic Peptide in Myocardium of Sudden Death due to Hypersensitivity and Coronary Atherosclerotic Heart Disease.
Fatality Involving Complications of Bupivacaine Toxicity and Hypersensitivity Reaction*
Fluorescein-induced allergic reaction.
Food-induced anaphylaxis.
GPER-mediated, oestrogen-dependent visceral hypersensitivity in stressed rats is associated with mast cell tryptase and histamine expression.
Helicobacter pylori as a protective factor against food allergy.
Heparin antagonists are potent inhibitors of mast cell tryptase.
Heparin-induced recurrent anaphylaxis.
Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study.
Histamine, tryptase, norepinephrine, angiotensinogen, angiotensin-converting enzyme, angiotensin I and II in plasma of patients with hymenoptera venom anaphylaxis.
How much specific is the association between hymenoptera venom allergy and mastocytosis?
Humoral and cellular responses to histamine and pollen allergen in a skin chamber model: effect of mizolastine.
Hymenoptera venom immunotherapy and field stings.
Immediate Hypersensitivity to Contrast Agents: The French 5-year CIRTACI Study.
Immunoglobulin E-Mediated Hypersensitivity Reaction to Ketamine.
Impact of Age and Heterophilic Interference on the Basal Serum Tryptase, a Risk Indication for Anaphylaxis, in 1,092 Dermatology Patients.
Importance of serum basal tryptase levels in children with insect venom allergy.
Improvement of the Elevated Tryptase Criterion to Discriminate IgE- From Non-IgE-Mediated Allergic Reactions.
Improvement of the Elevated Tryptase Criterion to Discriminate IgE- From Non-IgE-Mediated Allergic Reactions: Erratum.
In vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model.
Increased mast cell tryptase in sudden infant death - anaphylaxis, hypoxia or artefact?
Increased osteopontin levels in children undergoing venom immunotherapy may serve as a marker of clinical efficacy.
Induction of vascular permeability enhancement by human tryptase: dependence on activation of prekallikrein and direct release of bradykinin from kininogens.
Influence of total and specific IgE, serum tryptase, and age on severity of allergic reactions to Hymenoptera stings.
Interleukin 6 and C-reactive protein levels in patients with acute allergic reactions: an emergency department-based study.
Intraoperative anaphylaxis due to gelofusine in a patient undergoing intramedullary nailing of the femur: a case report.
Investigation of the factors that determine the severity of allergic reactions to Hymenoptera venoms.
In Vitro Diagnosis of Immediate Drug Hypersensitivity During Anesthesia: A Review of the Literature.
Is mast cell activation during asthmatic reaction reflected in the circulation?
Kounis Syndrome as First Manifestation of Allergic Sensitization.
Kounis syndrome following beta-lactam antibiotic use: review of literature.
Latex anaphylaxis causing heart block: role of ranitidine.
Mast Cell Activation During Suspected Perioperative Hypersensitivity: A Need for Paired Samples Analysis.
Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure.
Mast cell tryptase, a still enigmatic enzyme.
Mastocytosis and Hymenoptera venom allergy.
Mastocytosis and insect venom allergy.
Measurement of Tryptase and CC16/Albumin in Nasal Lavage Fluid as a Screening Tool of Allergic Rhinitis.
Mechanisms Involved in Hypersensitivity Reactions to Polysulfone Hemodialysis Membranes.
Metabonomics delineates allergic reactions induced by Shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry.
Metformin prevents colonic barrier dysfunction by inhibiting mast cell activation in maternal separation-induced IBS-like rats.
Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells.
Nasal and bronchial responses to flour-inhalation in subjects with occupationally induced allergy affecting the airway.
Nasal complaints and signs of disease in farmers - a methodological study.
Nasal lavage fluid examination in diagnostics of occupational allergy to chloramine.
Neuroendocrinology of mast cells: Challenges and controversies.
New developments in the diagnosis and treatment of hymenoptera venom allergy.
Optimal skin prick wheal size for diagnosis of cat allergy.
Over- and underestimated parameters in severe Hymenoptera venom-induced anaphylaxis: Cardiovascular medication and absence of urticaria/angioedema.
Perioperative Allergic Reactions: Allergy Assessment and Subsequent Anesthesia.
Perioperative anaphylaxis: diagnostic challenges and management.
Possible biological and translational significance of mast cells density in colorectal cancer.
Potent induction of a neutrophil and eosinophil-rich infiltrate in vivo by human mast cell tryptase: selective enhancement of eosinophil recruitment by histamine.
Potential Patent Blue V Overdose in a Patient Undergoing Free-Flap Breast Reconstruction: A Case Report.
Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity.
Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase.
Presence or absence of elevated acute total serum tryptase by itself is not a definitive marker for an allergic reaction.
Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain.
Radiocontrast anaphylaxis with failure of premedication.
Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?
Refined diagnostic criteria for bone marrow mastocytosis: a proposal of the European competence network on mastocytosis.
Relevance of histamine and tryptase concentrations in nasal secretions after nasal challenges with phosphate buffered saline and allergen.
Remimazolam anaphylaxis during anesthesia induction.
Review of topical gelatin-based haemostatic agents; an insidious culprit of intraoperative anaphylaxis?
Role of quercetin (a natural herbal compound) in allergy and inflammation.
Role of tryptase, eosinophil cationic protein and histamine in immediate allergic reactions to drugs.
Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone.
Safety of 100 µg venom immunotherapy rush protocols in children compared to adults.
Segmental allergen challenge induces plasma protein leakage into the airways of asthmatic subjects at 4 hours but not at 5 minutes after challenge.
Self-reported drug allergies and the diagnostic work-up in the surgical population.
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy.
Serum concentration of baseline mast cell tryptase: evidence for a decline during long-term immunotherapy for Hymenoptera venom allergy.
Serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy.
Serum tryptase determination in patients with acute allergic reactions.
Specificity and sensitivity assessment of selected nasal provocation testing techniques.
Sudden death associated with food and exercise.
Systematic follow-up increases incidence of anaphylaxis during adverse reactions in anesthetized patients.
Systemic reactions and anaphylaxis with an acute serum tryptase ?14 ?g/L: retrospective characterisation of aetiology, severity and adherence to National Institute of Health and Care Excellence (NICE) guidelines for serial tryptase measurements and specialist referral.
The immunopharmacology of mild asthma.
The incidence and management of infusion reactions to infliximab: a large center experience.
The level of tryptase in human tears. An indicator of activation of conjunctival mast cells.
The role of eosinophils in the pathophysiology of asthma.
The significance of diagnosing associated clonal mast cell diseases in patients with venom-induced anaphylaxis and the role of bone marrow investigation.
The usefulness of plasma histamine and different tryptase cut-off points in the diagnosis of peranaesthetic hypersensitivity reactions.
TIA1 and mast cell tryptase in food allergy of children: increase of intraepithelial lymphocytes expressing TIA1 associates with allergy.
TRYPTASE AND HISTAMINE MAY SUPPORT ORAL FOOD CHALLENGE IN THE DIAGNOSIS OF ALLERGY.
Tryptase as a polyfunctional component of mast cells.
Tryptase in diagnosing adverse suspected anaphylactic reaction.
Tryptase in nasal fluid is a useful marker of allergic rhinitis.
Tryptase levels in coronary syndromes and in hypersensitivity episodes: A common pathway towards Kounis syndrome.
Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response.
Tryptase values in anaphylaxis and insect allergy.
Tryptase: a clinical indicator of mast cell-dependent events.
Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation.
Ulcerative colitis patients with an inflammatory response upon mesalazine cannot be desensitized: a randomized study.
Update on Insect Sting Anaphylaxis.
Use and Interpretation of Acute and Baseline Tryptase in Perioperative Hypersensitivity and Anaphylaxis.
Use of basophil activation test in the investigation of adverse effects to vaccines.
Usefulness of UniCAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis.
Variations of serum eosinophil cationic protein and tryptase, measured in serum and saliva, during the course of immediate allergic reactions to foods.
VEGF is involved in the increase of dermal microvascular permeability induced by tryptase.
[A Case of Rocuronium-induced Anaphylaxis in Which Surgery was Subsequently Performed under General Anesthesia without Neuromuscular Blocking Agents].
[Airway autonomic nervous system dysfunction and asthma]
[Allergic reactions and pseudoallergies in surgical interventions with general anesthesia]
[Analysis of tryptase levels in infants and children with wheezy bronchitis]
[Anaphylactic reaction versus carcinoid crisis: the role of octreotide as a vasoconstrictor]
[Anaphylaxis sugammadex-induced in a pediatric patient].
[Anesthesia in a patient with history of multiple drug allergies]
[Dermal reactions in children with atopic dermatitis--changes in histamine/tryptase levels in skin chambers. Report 1]
[Determination of the tryptase level as diagnostic marker in food allergy in children]
[Establishment of new evaluation standards for systemic anaphylactoid reactions using mouse model].
[Exercise-induced anaphylaxis].
[HEREDITARY ALPHA TRYPTASEMIA - NEW DIAGNOSIS, FAMILIAR SYMPTOMS].
[Levels of interleukin-4, interleukin-5, tryptase and eosinophil cationic protein of nasal lavage fluid in pollen allergic rhinitis]
[Metabolomics of bovine serum albumin-induced allergic reactions based on UPLC-Q-TOF-MS].
[Present study on the forensic medicine diagnosis of the sudden erethistic death]
[Standards and pitfalls of in-vitro diagnostics of Hymenoptera venom allergy.]
[Tryptase, a marker for the activation and localization of mast cells]
Hypersensitivity, Immediate
A confirmed case of sugammadex-induced anaphylaxis in a UK hospital.
Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis.
Diagnostic procedure after an immediate hypersensitivity reaction in the operating room.
Generation of C3a anaphylatoxin from human C3 by human mast cell tryptase.
Immunoglobulin E-Mediated Hypersensitivity Reaction to Ketamine.
In Vivo Cysteinyl Leukotriene Release in Allergic and Nonallergic Immediate Hypersensitivity Reactions during Anesthesia.
Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure.
Matriptase expression in the normal and neoplastic mast cells.
The incidence and management of infusion reactions to infliximab: a large center experience.
Tryptase: a clinical indicator of mast cell-dependent events.
Use and Interpretation of Acute and Baseline Tryptase in Perioperative Hypersensitivity and Anaphylaxis.
[Allergic reactions and pseudoallergies in surgical interventions with general anesthesia]
[Allergy to iodinated drugs and to foods rich in iodine: Iodine is not the allergenic determinant].
[Immediate allergy to iodinated contrast agents and prevention of reactions.]
Hypertension
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old.
Identification of risk factors of severe hypersensitivity reactions in general anaesthesia.
Hypertension, Pulmonary
Mast cell peptidases: chameleons of innate immunity and host defense.
Hypoalbuminemia
KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
Hypotension
Anaphylaxis and Clinical Utility of Real-World Measurement of Acute Serum Tryptase in UK Emergency Departments.
Anaphylaxis caused by butylscopolamine bromide: a case report.
Clinical aspects of paediatric mastocytosis: a review of 101 cases.
Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.
Diagnostic Value of Tryptase in Food Allergic Reactions: A Prospective Study of 160 Adult Peanut Challenges.
Elevated serum cytokines during human anaphylaxis: Identification of potential mediators of acute allergic reactions.
Hymenoptera Anaphylaxis and C-kit Mutations: An Unexpected Association.
Management and Prevention of Anaphylaxis.
Pseudoanaphylaxis.
Refractory intraoperative hypotension with elevated serum tryptase.
Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia.
[A case of anaphylactic shock induced by latex during cesarean section].
Idiopathic Pulmonary Fibrosis
Immunofluorescent staining for mast cells in idiopathic pulmonary fibrosis: quantification and evidence for extracellular release of mast cell tryptase.
Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease.
Ileitis
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Infections
A novel membrane-bound serine esterase in human T4(+)-lymphocytes is a binding protein of envelope glycoprotein gp120 of HIV-1.
Acute hypersensitive-like injury in specific-pathogen-free chickens after infection with very virulent infectious bursal disease virus.
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Cloning of the cDNA encoding mast cell tryptase of Mongolian gerbil, Meriones unguiculatus, and its preferential expression in the intestinal mucosa.
Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer.
Dengue vascular leak syndrome: insights into potentially new treatment modalities.
Dengue virus-elicited tryptase induces endothelial permeability and shock.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung.
Evidence for a role of mast cells in the mucosal injury induced by Newcastle disease virus.
Expression of mast cell proteases in rat lung during helminth infection: mast cells express both rat mast cell protease II and tryptase in helminth infected lung.
Expulsion of Secondary Trichinella spiralis Infection in Rats Occurs Independently of Mucosal Mast Cell Release of Mast Cell Protease II.
Helicobacter pylori as a protective factor against food allergy.
Helicobacter pylori infection and mast cells of the antrum mucosa.
Helicobacter pylori non-cytotoxic genotype enhances mucosal gastrin and mast cell tryptase.
Immunological characteristics of patients infected with common intestinal helminths: results of a study based on reverse-transcriptase PCR.
Immunological responses elicited by different infection regimes with Strongyloides ratti.
Increased Mast Cell Activation in Mongolian Gerbils Infected by Hepatitis E Virus.
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Inhibitory effect of pulmonary surfactant on Sendai virus infection in rat lungs.
Mast Cell Activation and KSHV Infection in Kaposi Sarcoma.
Mast cell involvement in gastritis with or without Helicobacter pylori infection.
Mast cell mediated inflammatory response in chickens after infection with very virulent infectious bursal disease virus.
Mast cell mediators in relation to dengue severity: A systematic review and meta-analysis.
Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses. Purification and characterization.
Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus.
Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection.
Protease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.
Pulmonary surfactant is a potential endogenous inhibitor of proteolytic activation of Sendai virus and influenza A virus.
Reduced mucosal injury of SPF chickens by mast cell stabilization after infection with very virulent infectious bursal disease virus.
Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N brasiliensis infection.
Stem cell factor dependent hyperplasia of mucosal-type mast cells but not eosinophils in Schistosoma mansoni-infected rats.
The effect of infection history on the fitness of the gastrointestinal nematode Strongyloides ratti.
The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis.
Tryptase: Genetic and functional considerations.
Infertility
Are testicular mast cells involved in the regulation of germ cells in man?
Mast Cells in Peritoneal Fluid From Women With Endometriosis and Their Possible Role in Modulating Sperm Function.
Novel finding of high density of activated mast cells in endometrial polyps.
Infertility, Male
Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling.
Inflammatory Bowel Diseases
Activation of ion secretion via proteinase-activated receptor-2 in human colon.
Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis.
Basic and translational research on proteinase-activated receptors: implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation.
Corticosteroid treatment reduces mast cell numbers in inflammatory bowel disease.
Effect of colonoscopy premedication containing diazepam and pethidine on the release of mast cell mediators in gut mucosal samples.
Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.
Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC).
Release of mast cell tryptase from human colorectal mucosa in inflammatory bowel disease.
Review article: anti-tryptase therapy in inflammatory bowel disease.
[Tryptase activity in colon mucosal samples of children with inflammatory bowel disease]
Influenza, Human
A novel influenza A virus activating enzyme from porcine lung: purification and characterization.
Accumulation of mini-plasmin in the cerebral capillaries causes vascular invasion of the murine brain by a pneumotropic influenza A virus: implications for influenza-associated encephalopathy.
Cellular proteases involved in the pathogenicity of enveloped animal viruses, human immunodeficiency virus, influenza virus A and Sendai virus.
Electron immunohistochemical localization in rat bronchiolar epithelial cells of tryptase Clara, which determines the pneumotropism and pathogenicity of Sendai virus and influenza virus.
Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses.
Isolation and characterization of a novel trypsin-like protease found in rat bronchiolar epithelial Clara cells. A possible activator of the viral fusion glycoprotein.
Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses. Purification and characterization.
Mini-plasmin found in the epithelial cells of bronchioles triggers infection by broad-spectrum influenza A viruses and Sendai virus.
Pulmonary surfactant is a potential endogenous inhibitor of proteolytic activation of Sendai virus and influenza A virus.
Sendai virus infection changes the subcellular localization of tryptase Clara in rat bronchiolar epithelial cells.
The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses.
[The role of cleavage activation of the hemagglutinin by host and bacterial proteases in the induction of the pathogenesis of influenza viruses]
Insulin Resistance
Involvement of mast cells in adipose tissue fibrosis.
Intestinal Diseases
Induction of tryptase and histamine release from human colon mast cells by IgE dependent or independent mechanisms.
Irritable Bowel Syndrome
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
IRRITABLE BOWEL SYNDROME AND BASAL SERUM TRYPTASE: THE CORRELATION BETWEEN SUBTYPE, SEVERITY AND COMORBIDITIES. A PILOT STUDY.
Mast cell tryptase reduces junctional adhesion molecule-A (JAM-A) expression in intestinal epithelial cells: implications for the mechanisms of barrier dysfunction in irritable bowel syndrome.
Psoriasis patients have highly increased numbers of tryptase-positive mast cells in the duodenal stroma.
Reduced Responses of Submucous Neurons from Irritable Bowel Syndrome Patients to a Cocktail Containing Histamine, Serotonin, TNF?, and Tryptase (IBS-Cocktail).
Role of mast cell-miR-490-5p in irritable bowel syndrome.
Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome.
Tryptase potentiates enteric nerve activation by histamine and serotonin: Relevance for the effects of mucosal biopsy supernatants from irritable bowel syndrome patients.
[Electroacupuncture of "Tianshu" (ST 25) Suppresses Visceral Pain Possibly by Down-regulating Mast Cell Activation, and Tryptase and SP Expression in Rats with Post-infectious Irritable Bowel Syndrome].
Jaw Cysts
Mast cell-derived tryptase in odontogenic cysts.
Joint Instability
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Keloid
Comparative proteomic analysis between normal skin and keloid scar.
Expression of Cathepsins B, D, and G by the Embryonic Stem Cell-Like Population within Human Keloid Tissues and Keloid-Derived Primary Cell Lines.
Expression of Components of the Renin-angiotensin System by Embryonic Stem Cell-like Population within Keloid Lesions.
Expression of Components of the Renin-Angiotensin System by the Embryonic Stem Cell-Like Population within Keloid Lesions.
Long-term organ culture of keloid disease tissue.
Mast cells in human keloid, small intestine, and lung by an immunoperoxidase technique using a murine monoclonal antibody against tryptase.
Tryptase-positive mast cells and angiogenesis in keloids: a new possible post-surgical target for prevention.
[Expression of mast cell tryptase in scar]
Keratoconjunctivitis
Hyperexpression of the high-affinity IgE receptor-{beta} chain in chronic allergic keratoconjunctivitis.
Mast cell hyperplasia in atopic keratoconjunctivitis. An immunohistochemical study.
Kidney Diseases
Leukocyte populations in interstitial cystitis and idiopathic reduced bladder storage.
Kidney Failure, Chronic
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Serum tryptase concentration and progression to end-stage renal disease.
Kounis Syndrome
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Anaphylaxis-induced hyperfibrinogenolysis and the risk of Kounis syndrome: the dual action of tryptase.
Mast cell tryptase level should be checked in all patients with suspected Kounis syndrome.
Serum tryptase levels and Kounis syndrome.
Tryptase levels in coronary syndromes and in hypersensitivity episodes: A common pathway towards Kounis syndrome.
Latex Hypersensitivity
Allergen specific nasal challenge to latex in children with latex allergy: clinical and immunological evaluation.
Elevated serum tryptase level in a case of intraoperative anaphylaxis caused by latex allergy.
Leg Ulcer
Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors.
Leiomyoma
Mast cells in smooth muscle tumors of the uterus.
Mast cells or not? - CD117 positive cells in esophageal leiomyoma.
The role of mast cells and angiogenesis in benign and malignant neoplasms of the uterus.
Tryptase- and leptin-positive mast cells correlate with vascular density in uterine leiomyomas.
Leiomyosarcoma
Mast cells in smooth muscle tumors of the uterus.
Leprosy
Leprosy: contribution of mast cells to epineurial collagenization.
Leukemia
Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings.
Diagnostic value of immunostaining for tryptase in patients with mastocytosis.
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia.
Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: evidence for expression of CD2, CD117/Kit, and bcl-x(L).
Interactions of proteases and protease inhibitors in Sertoli-germ cell cocultures preceding the formation of specialized Sertoli-germ cell junctions in vitro.
Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia.
Quercetin-induced expression of rat mast cell protease II and accumulation of secretory granules in rat basophilic leukemia cells.
Serum total tryptase level confirms itself as a more reliable marker of mast cells burden in mast cell leukaemia (aleukaemic variant).
Serum tryptase measurements in patients with myelodysplastic syndromes.
[Tryptase relation to VEGF in acute leukemia]
Leukemia, Large Granular Lymphocytic
Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia.
Leukemia, Mast-Cell
Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: evidence for expression of CD2, CD117/Kit, and bcl-x(L).
Serum total tryptase level confirms itself as a more reliable marker of mast cells burden in mast cell leukaemia (aleukaemic variant).
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms.
Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.
The serum tryptase test: an emerging robust biomarker in clinical hematology.
Tryptase Positivity in Chronic Myeloid Leukemia With Marked Basophilia.
Leukemia, Myeloid
Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis.
Mast cell tryptase and microphthalmia transcription factor effectively discriminate cutaneous mast cell disease from myeloid leukemia cutis.
Paraffin section immunophenotype of cutaneous and extracutaneous mast cell disease: comparison to other hematopoietic neoplasms.
Leukemia, Myeloid, Acute
beta-Tryptase up-regulates vascular endothelial growth factor expression via proteinase-activated receptor-2 and mitogen-activated protein kinase pathways in bone marrow stromal cells in acute myeloid leukemia.
Evaluation of biologic activity of tryptase secreted from blast cells in acute myeloid leukemia.
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia.
Myelomastocytic leukemia: evidence for the origin of mast cells from the leukemic clone and eradication by allogeneic stem cell transplantation.
Quantitation of minimal residual disease in acute myeloid leukemia by tryptase monitoring identifies a group of patients with a high risk of relapse.
SCF/C-KIT signaling modulates tryptase expression in acute myeloid leukemia cells.
The serum tryptase test: an emerging robust biomarker in clinical hematology.
Total serum tryptase: A predictive marker for KIT mutation in acute myeloid leukemia.
Tryptase a novel biochemical marker of acute myeloid leukemia.
[Preliminary study of relationship between tryptase and angiogenesis in acute myeloid leukemia patients].
[Tryptase relation to VEGF in acute leukemia]
Leukemia, Myelomonocytic, Chronic
Serum tryptase measurements in patients with myelodysplastic syndromes.
Leukoplakia
Decrease in mast cells in oral squamous cell carcinoma: possible failure in the migration of these cells.
Immunohistochemical Evaluation of Mast Cells in Leukoplakia and Oral Squamous Cell Carcinoma.
Linear IgA Bullous Dermatosis
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Lipidoses
Role of mast cell chymase and tryptase in the progression of atherosclerosis: study in 44 autopsied cases.
Liver Cirrhosis
Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors.
Liver Cirrhosis, Biliary
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Liver Diseases
Distribution of intrahepatic mast cells in various hepatobiliary disorders. An immunohistochemical study.
Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synthesis induced by tryptase/protease-activated receptor 2 interactions in hepatic stellate cells.
Liver Diseases, Alcoholic
Mast cell subpopulations in chronic inflammatory hepatobiliary diseases.
Liver Neoplasms
Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients.
Lung Diseases
Crosstalk between Mast Cells and Lung Fibroblasts Is Modified by Alveolar Extracellular Matrix and Influences Epithelial Migration.
Mast cells and mast cell tryptase enhance migration of human lung fibroblasts through protease-activated receptor 2.
Tryptase inhibitors in the treatment of pulmonary diseases.
Lung Diseases, Interstitial
Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease.
[The clinical significance of mast cell tryptase in bronchial alveolar lavage fluid in interstitial lung diseases]
Lung Injury
Mast Cell-Induced Lung Injury in Mice Infected with H5N1 Influenza Virus.
Mast-Cell-Releasing Tryptase Triggers Acute Lung Injury Induced by Small Intestinal Ischemia-Reperfusion by Activating PAR-2 in Rats.
Physiology and pathophysiology of proteinase-activated receptors (PARs): role of tryptase/PAR-2 in vascular endothelial barrier function.
Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury.
Lung Neoplasms
[Study of mast cell, eosinophil and fibroblast activation in bronchoalveolar lavage fluid in patients with lung cancer]
Lymphadenopathy
Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.
Indolent systemic mastocytosis associated with atypical small lymphocytic lymphoma: a rare form of concomitant lymphoproliferative disease.
KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance.
KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
Lymphangioleiomyomatosis
Mast-Cell Tryptase Release Contributes to Disease Progression in Lymphangioleiomyomatosis.
Lymphatic Metastasis
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Mast cell tryptase promotes breast cancer migration and invasion.
Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery.
Lymphocytosis
An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL).
Lymphoma
Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.
Introns excised from immunoglobulin pre-mRNAs exist as discrete species.
Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.
Tumor Cell Microenvironment and Microvessel Density Analysis in MALT Type Lymphoma.
Lymphoma, B-Cell
Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma.
Lymphoma, Follicular
Mast cells contribute to the angiogenesis in non-Hodgkin lymphoma. An immunohistochemical study based on the relationship with microvessel density.
Lymphoma, Large B-Cell, Diffuse
Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma.
Lymphoma, Non-Hodgkin
Demonstration of tryptase in bovine cutaneous and tumor mast cells.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Mast Cell Activation Disorders
Anaphylaxis caused by Hymenoptera stings: from epidemiology to treatment.
Cardiovascular symptoms in patients with systemic mast cell activation disease.
Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms.
Clonal Mast Cell Proliferation in Pruriginous Skin in Hypereosinophilic Syndrome.
Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.
Factors that predict disease severity in atopic dermatitis: The role of serum basal tryptase.
First Identification of an Inherited TPSAB1 Quintuplication in a Patient with Clonal Mast Cell Disease.
Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies.
Insect Sting Anaphylaxis-Or Mastocytosis-Or Something Else?
Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.
Mast cell activation in the context of elevated basal serum tryptase: genetics and presentations.
Mast Cell Burden in a Patient With Cutaneous Disease
Mast cell tryptase and microphthalmia transcription factor effectively discriminate cutaneous mast cell disease from myeloid leukemia cutis.
Mastocytosis and Hymenoptera venom allergy.
New Developments in Diagnosis, Prognostication, and Treatment of Advanced Systemic Mastocytosis.
Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone.
Self-medication of anaphylactic reactions due to Hymenoptera stings-an EAACI Task Force Consensus Statement.
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy.
Systemic mastocytosis: classification, pathogenesis, diagnosis, and treatment.
The significance of diagnosing associated clonal mast cell diseases in patients with venom-induced anaphylaxis and the role of bone marrow investigation.
[Mast cell activation syndrome. About a clinical case].
Mast Cell Activation Syndrome
A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome
Anti-Amoxicillin Immunoglobulin E, Histamine-2 Receptor Antagonist Therapy and Mast Cell Activation Syndrome Are Risk Factors for Amoxicillin Anaphylaxis.
Clinical Approach to Mast Cell Activation Syndromes: A Practical Overview.
Clonal Mast Cell Proliferation in Pruriginous Skin in Hypereosinophilic Syndrome.
Insect Sting Anaphylaxis-Or Mastocytosis-Or Something Else?
Mast cell activation syndrome: improved identification by combined determinations of serum tryptase and 24-hour urine 11?-prostaglandin2?.
Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome.
[Tryptase: A practical guide for the physician].
Mastocytoma
Characterisation of tryptase and a granzyme H-like chymase isolated from equine mastocytoma tissue.
Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining.
Cloning and expression of the dog mast cell alpha-chymase gene.
Cloning and structural analysis of MMCP-1, MMCP-4 and MMCP-5, three mouse mast cell-specific serine proteases.
Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence.
Enzyme- and immunohistochemical localization of mast cell tryptase in psoriatic skin.
Flushing and increase of serum typtase after mechanical irritation of a solitary mastocytoma.
Histiocyte-rich pleomorphic mastocytoma: an uncommon variant mimicking juvenile xanthogranuloma and Langerhans cell histiocytosis.
Immunoperoxidase and enzyme-histochemical demonstration of human skin tryptase in cutaneous mast cells in normal and mastocytoma skin.
Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene.
Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.
Mast cell alpha-chymase reduces IgE recognition of birch pollen profilin by cleaving antibody-binding epitopes.
Mast cell and neutrophil expression of dog mast cell protease-3. A novel tryptase-related serine protease.
Mast cell chymase. A potent secretagogue for airway gland serous cells.
Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret.
Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase.
Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment.
Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines.
Mastocytoma, Skin
Diagnostic value of immunostaining for tryptase in patients with mastocytosis.
Mastocytosis
A case of bone marrow mastocytosis associated with multiple myeloma.
Acute Myeloid Leukemia With Inv(16)(p13q22) Associated With Hidden Systemic Mastocytosis: Case Report and Review of Literature.
Added sensitivity of component-resolved diagnosis in hymenoptera venom-allergic patients with elevated serum tryptase and/or mastocytosis.
Adult-onset mastocytosis in the skin is highly suggestive of systemic mastocytosis.
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
An unusual cause of spontaneous bleeding in the intensive care unit - mastocytosis: a case report.
Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients.
Anaphylaxis with clonal mast cells in normal looking skin - a new entity?
Are gastrointestinal mucosal mast cells increased in patients with systemic mastocytosis?
Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis.
Assessment of the extent of cutaneous involvement in children and adults with mastocytosis: relationship to symptomatology, tryptase levels, and bone marrow pathology.
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers.
Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin.
Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly.
Bone marrow mastocytosis associated with an undifferentiated extramedullary tumor of hemopoietic origin.
Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.
Cardiovascular disease and anaphylaxis.
Cardiovascular symptoms in patients with systemic mast cell activation disease.
Case Report: Mastocytosis: The Long Road to Diagnosis.
Case Report: Perioperative immediate hypersensitivity involves not only allergy but also mastocytosis.
Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study.
Clinical and Laboratory Parameters of Mast Cell Activation as Basis for the Formulation of Diagnostic Criteria.
Clinical aspects of paediatric mastocytosis: a review of 101 cases.
Clonal mast cell disorders in patients with severe Hymenoptera venom allergy and normal serum tryptase levels.
Comparison of serum tryptase and urine N-methylhistamine in patients with suspected mastocytosis.
Conditioned media obtained from a human mastocytosis cell strain induce mast cells expressing chymase but not tryptase from human progenitors.
Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings.
Control of hypereosinophilic syndrome-associated recalcitrant coronary artery spasm by combined treatment with prednisone, imatinib mesylate and hydroxyurea.
Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis: relationship with basal serum tryptase.
Cutaneous mastocytosis treatment: strategies, limitations and perspectives.
Detection of KIT D816V in peripheral blood of children with manifestations of cutaneous mastocytosis suggests systemic disease.
Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines.
Diagnosis of Hymenoptera venom allergy.
Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings.
Diagnosis of Primary Mast Cell Disorders in Anaphylaxis: Value of KIT D816V in Peripheral Blood.
Diagnostic procedure after an immediate hypersensitivity reaction in the operating room.
Diagnostic value of immunostaining for tryptase in patients with mastocytosis.
Diagnostic value of tryptase in anaphylaxis and mastocytosis.
Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects.
Disease spectrum in patients with elevated serum tryptase levels.
Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis.
Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy.
Elevated baseline serum tryptase, mastocytosis and anaphylaxis.
Elevated Serum Tryptase in Non-Anaphylaxis Cases: A Concise Review.
Elevated tryptase levels are associated with greater bone density in a cohort of patients with mastocytosis.
Elevation in histamine and tryptase following exercise in patients with mastocytosis.
Expulsion of Secondary Trichinella spiralis Infection in Rats Occurs Independently of Mucosal Mast Cell Release of Mast Cell Protease II.
Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood.
Flow-mediated dilation shows impaired endothelial function in patients with mastocytosis.
Frequency of isolated cutaneous involvement in adult mastocytosis: a cohort study.
Gene expression analysis in mastocytosis reveals a highly consistent profile with candidate molecular markers.
Genetic Regulation of Tryptase Production and Clinical Impact: Hereditary Alpha Tryptasemia, Mastocytosis and Beyond.
Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM).
Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis.
How much specific is the association between hymenoptera venom allergy and mastocytosis?
Human mast cell tryptase in biology and medicine.
Hymenoptera Allergy and Mast Cell Activation Syndromes.
Hymenoptera Anaphylaxis as a Clonal Mast Cell Disorder.
Hymenoptera venom allergy.
IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.
Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: evidence for expression of CD2, CD117/Kit, and bcl-x(L).
Immunophenotype of bone marrow mast cells in indolent systemic mast cell disease in adults.
Impact of mental health on disease activity in mastocytosis during COVID-19 pandemic.
Increased serum baseline tryptase levels and extensive skin involvement are predictors for the severity of mast cell activation episodes in children with mastocytosis.
Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes.
Interleukin-31: a novel diagnostic marker of allergic diseases.
International prognostic scoring system for mastocytosis (IPSM): a retrospective cohort study.
Involvement of mast cells in eosinophilic esophagitis.
Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase.
Long-term outcome after venom immunotherapy.
Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients.
Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases.
Mast Cell Burden in a Patient With Cutaneous Disease
Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias.
Mast cell involvement in interstitial cystitis: a review of human and experimental evidence.
Mast cell tryptase in sera of patients with Crohn's disease and mastocytosis.
Mast cells expressing chymase but not tryptase can be derived by culturing human progenitors in conditioned medium obtained from a human mastocytosis cell strain with c-kit ligand.
Mast cells in cutaneous mastocytosis: accumulation of the MCTC type.
Mast-cell phenotype in indolent forms of mastocytosis. Ultrastructural features, fluorescence detection of avidin binding, and immunofluorescent determination of chymase, tryptase, and carboxypeptidase.
Mastocytosis and allergy.
Mastocytosis and Hymenoptera venom allergy.
Mastocytosis and insect venom allergy.
Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels.
Mastocytosis presenting as cardiac emergency.
Mastocytosis.
Mastocytosis: a comprehensive insight.
Mastocytosis: immunophenotypical features of the transformed mast cells are unique among hematopoietic cells.
Mastocytosis: the puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease.
Microdialysis of histamine in the skin of patients with mastocytosis.
Mouse mast cells that possess segmented/multi-lobular nuclei.
Multidisciplinary Challenges in Mastocytosis and How to Address with Personalized Medicine Approaches.
Neuropeptide blood levels correlate with mast cell load in patients with mastocytosis.
No relationship between histamine release measured as metabolite excretion in the urine, and serum levels of mast cell specific tryptase in mastocytosis.
Omalizumab ensures compatibility to bee venom immunotherapy (VIT) after VIT-induced anaphylaxis in a patient with systemic mastocytosis.
Overexpression of p16(INK4a) in Mastocytosis (Urticarial Pigmentosa).
Patients still reacting to a sting challenge while receiving conventional Hymenoptera venom immunotherapy are protected by increased venom doses.
PD34 - Childhood mastocytosis: serum baseline total tryptase levels and extent of cutaneous disease as predictors of mast cell mediator release symptoms.
Pediatric Mastocytosis: A Review of the Literature.
Prevalence of mastocytosis and hymenoptera venom allergy in the United States.
Prevention of Mast Cell Activation Disorder-Associated Clinical Sequelae of Excessive Prostaglandin D(2) Production.
Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis.
Pseudoanaphylaxis.
Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis.
Raised tryptase without anaphylaxis or mastocytosis: heterophilic antibody interference in the serum tryptase assay.
Recent advances in our understanding of mast cell activation - or should it be mast cell mediator disorders?
Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis.
Risk factors in Hymenoptera venom allergy.
Serum interleukin-6 reflects disease severity and osteoporosis in mastocytosis patients.
Serum tryptase and SCORMA (SCORing MAstocytosis) Index as disease severity parameters in childhood and adult cutaneous mastocytosis.
Serum tryptase levels in patients with mastocytosis: correlation with mast cell burden and implication for defining the category of disease.
Serum tryptase levels in pediatric mastocytosis and association with systemic symptoms.
Serum tryptase measured with B12 and G5 antibody-based immunoassays in mastocytosis patients and its relation to histamine turnover.
Solitary mastocytoma presenting in an adult: report and literature review of adult-onset solitary cutaneous mastocytoma with recommendations for evaluation and treatment.
Surrogate markers of disease in mastocytosis.
Systemic mastocytosis identified in two women developing fragility fractures during lactation.
Systemic mastocytosis presenting with a prominent B lymphocyte proliferation in the bone marrow and extensive fibrosis of the spleen.
Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: a histopathological challenge.
The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis.
The causes of a peripheral blood eosinophilia in a secondary care setting.
The problem of anaphylaxis and mastocytosis.
The role of serum tryptase in the diagnosis and monitoring of pediatric mastocytosis: a single-center experience.
The serum tryptase test: an emerging robust biomarker in clinical hematology.
The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma.
Tryptase detection in bone-marrow blood: a new diagnostic tool in systemic mastocytosis.
Tryptase genetics and anaphylaxis.
Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels.
Tryptase Increase without Mastocytosis or Anaphylaxis.
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Usefulness of Dual X-ray Absorptiometry-Derived Bone Geometry and Structural Indexes in Mastocytosis.
Validation of the REMA Score for Predicting Mast Cell Clonality and Systemic Mastocytosis in Patients with Systemic Mast Cell Activation Symptoms.
Venom immunotherapy in patients with mastocytosis and hymenoptera venom anaphylaxis.
Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome.
[Mastocytosis: when should it be considered?]
[New variants of diagnostic procedures and therapeutic methods in insect venom allergy]
[Occult cutaneous mastocytosis]
[Tryptase, a marker for the activation and localization of mast cells]
[When the fluoro-immuno-enzymatic (FEIA) measurements turn out to be more sensitive than radioimmunologic (RIA) measurements. Application to the measurement of serum tryptase]
Mastocytosis, Cutaneous
Clinical aspects of paediatric mastocytosis: a review of 101 cases.
Co-localization of tryptase and cathepsin-G in mast cells in cutaneous mastocytosis.
Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis: relationship with basal serum tryptase.
Cutaneous mastocytosis in adults with a serum tryptase level < 20 ng mL-1 : why we should investigate further.
Cutaneous mastocytosis, problems of clinical diagnosis of four cases.
Detection of phospho-STAT5 in mast cells: a reliable phenotypic marker of systemic mast cell disease that reflects constitutive tyrosine kinase activation.
Diffuse cutaneous mastocytosis: Identification of KIT mutation and long-term follow-up with serum tryptase level.
Drug hypersensitivity in clonal mast cell disorders: ENDA/EAACI position paper.
Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers.
Mastocytosis and Hymenoptera venom allergy.
Mastocytosis: a comprehensive insight.
Pediatric mastocytosis.
Serum tryptase and SCORMA (SCORing MAstocytosis) Index as disease severity parameters in childhood and adult cutaneous mastocytosis.
Mastocytosis, Systemic
A novel heparin-dependent processing pathway for human tryptase. Autocatalysis followed by activation with dipeptidyl peptidase I.
A rare manifestation of indolent systemic mastocytosis and its management during the coronavirus disease 2019 pandemic; educational lessons from Syria.
Adult-onset mastocytosis in the skin is highly suggestive of systemic mastocytosis.
Anaphylactic risk due to systemic mastocytosis: Perioperative management in cardiac surgery.
Anaphylactoid reaction to intravenous contrast in patient with systemic mastocytosis.
Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis.
Bone marrow mast cell burden and serum tryptase level as markers of response in patients with systemic mastocytosis.
Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.
Cardiovascular disease and anaphylaxis.
Chapter 25: Idiopathic anaphylaxis.
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.
Clinical advances in mastocytosis.
Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders.
Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis: relationship with basal serum tryptase.
Detection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia.
Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.
Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects.
Effector cells of anaphylaxis: mast cells and basophils.
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Epidemiology, prognosis, and risk factors in mastocytosis.
Expression of alpha-tryptase and beta-tryptase by human basophils.
Heritable risk for severe anaphylaxis associated with increased ?-tryptase-encoding germline copy number at TPSAB1.
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis.
Hymenoptera-induced anaphylaxis: is it a mast cell driven hematological disorder?
Hypereosinophilic syndrome with elevated serum tryptase versus systemic mast cell disease associated with eosinophilia: 2 distinct entities?
Idiopathic anaphylaxis.
Impact of Centralized Evaluation of Bone Marrow Histology in Systemic Mastocytosis.
Indolent systemic mastocytosis as the cause of a long history of unexplained hypotensive episodes.
Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes.
KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance.
Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis.
Lack of evidence for intrathecal tryptase synthesis in patients with systemic mastocytosis.
Localization of tryptase to human cutaneous mast cells and keratinocytes by immunofluorescence and immunoperoxidase cytochemistry with monoclonal antitryptase antibody.
Markers of mast cell degranulation.
Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients.
Mast Cell Burden in a Patient With Cutaneous Disease
Mast Cell Mediators of Significance in Clinical Practice in Mastocytosis.
Mastocytosis and Hymenoptera allergy.
Mastocytosis onset in a patient with treated hairy cell leukemia: Just a coincidence?
Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation.
Morphologic and immunophenotypic properties of neoplastic cells in a case of mast cell sarcoma.
Myeloid Neoplasm with PDGFRA Rearrangement Manifesting as a Retromolar Pad Mass.
Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM.
Osteoporotic spinal burst fracture in a young adult as first presentation of systemic mastocytosis.
Pancreatic neuroendocrine tumor presenting in indolent systemic mastocytosis: A case report.
Pediatric mastocytosis.
Predictors of severe anaphylaxis in Hymenoptera venom allergy: The importance of absence of urticaria and angioedema.
Serum tryptase and the laboratory diagnosis of systemic mastocytosis.
Serum tryptase correlates with the KIT D816V mutation burden in adults with indolent systemic mastocytosis.
Serum tryptase monitoring in indolent systemic mastocytosis: association with disease features and patient outcome.
Systemic mastocytosis presenting with a prominent B lymphocyte proliferation in the bone marrow and extensive fibrosis of the spleen.
Systemic mastocytosis with normal serum tryptase: rule or exception?
The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in those with systemic mastocytosis.
The Italian Mastocytosis Registry: 6-year experience from a hospital-based registry.
The potential clinical utility of serum alpha-protryptase levels.
The presence of membrane-bound stem cell factor on highly immature nonmetachromatic mast cells in the peripheral blood of a patient with aggressive systemic mastocytosis.
The significance of diagnosing associated clonal mast cell diseases in patients with venom-induced anaphylaxis and the role of bone marrow investigation.
Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions.
Tryptase detection in bone-marrow blood: a new diagnostic tool in systemic mastocytosis.
Tryptase is not cleared by the kidneys into the urine.
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Two cases of elevated tryptase in abdominal aortic aneurysm.
Venom immunotherapy in indolent systemic mastocytosis with high serum tryptase level.
[Anaphylactoid reaction in occult systemic mastocytosis. A rare dermatologic emergency ]
[Mast cell activation syndrome. About a clinical case].
[Severe therapy refractive osteoporosis : A rare differential diagnosis].
[Systemic mastocytosis with refractory ascites successfully treated with interferon-? and a leukotriene receptor antagonist].
[Tryptase: A practical guide for the physician].
Megacolon
Mast cell-nerve interaction in the colon of Trypanosoma cruzi-infected individuals with chagasic megacolon.
Melanoma
Correlation of serum tryptase levels with total number of nevi, Breslow thickness, ulceration, and mitotic index in melanoma patients: evaluation of a promising prognostic marker.
Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression.
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma.
Protective role of mouse mast cell tryptase Mcpt6 in melanoma.
Serum tryptase levels in melanoma patients: case-control study and review of the literature.
Serum tryptase levels in melanoma patients: first results of clinicopathological features.
The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung.
Melanosis
Histochemical and Immunohistochemical Study in Melasma: Evidence of Damage in the Basal Membrane.
Meningioma
Evaluation of mast cells and hypoxia inducible factor-1 expression in meningiomas of various grades in correlation with peritumoral brain edema.
Mast cells evaluation in meningioma of various grades.
Mesothelioma
Tryptase mast cells in malignant pleural mesothelioma as an independent favorable prognostic factor.
Mesothelioma, Malignant
Tryptase mast cells in malignant pleural mesothelioma as an independent favorable prognostic factor.
Metabolic Diseases
Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases.
Metabolic Syndrome
Factors influencing serum total tryptase concentrations in a general adult population.
Tryptase as a marker of severity of aortic valve stenosis.
Metrorrhagia
Endometrial chemokines, uterine natural killer cells and mast cells in long-term users of the levonorgestrel-releasing intrauterine system.
Microphthalmos
Inhibitory effect of the transcription factor encoded by the mutant mi microphthalmia allele on transactivation of mouse mast cell protease 7 gene.
Involvement of MITF-A an alternative isoform of mi transcription factor on the expression of tryptase gene in human mast cells.
Involvement of MITF-A, an alternative isoform of mi transcription factor, on the expression of tryptase gene in human mast cells.
Mast cell tryptase and microphthalmia transcription factor effectively discriminate cutaneous mast cell disease from myeloid leukemia cutis.
Suppression of microphthalmia transcriptional activity by its association with protein kinase C-interacting protein 1 in mast cells.
Migraine Disorders
Mast Cell Activation in Children With Migraine Before and After Training in Self-regulation.
Multiple Sclerosis
Elevated mast cell tryptase in cerebrospinal fluid of multiple sclerosis patients.
Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.
The mast cells of the multiple sclerosis brain.
Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-alpha, IL-6 and IL-1 beta: possible relevance to multiple sclerosis.
Muscular Dystrophy, Duchenne
A possible role of tryptase in angiogenesis in the brain of mdx mouse, a model of Duchenne muscular dystrophy.
Myelodysplastic Syndromes
Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study.
Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Kit ligand/mast cell growth factor-independent differentiation of mast cells in myelodysplasia and chronic myeloid leukemic blast crisis.
Serum tryptase measurements in patients with myelodysplastic syndromes.
Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: a histopathological challenge.
The serum tryptase test: an emerging robust biomarker in clinical hematology.
Tryptase Positivity in Chronic Myeloid Leukemia With Marked Basophilia.
Myeloproliferative Disorders
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.
Myocardial Infarction
Acute coronary syndrome secondary to clarithromycin: the first case and review of the literature.
Aerobic Exercise-Assisted Cardiac Regeneration by Inhibiting Tryptase Release in Mast Cells after Myocardial Infarction.
beta-Tryptase measurements post-mortem in anaphylactic deaths and in controls.
Dynamic changes and clinical significance of serum tryptase levels in STEMI patients treated with primary PCI.
Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report.
High serum tryptase value in massive acute myocardial infarction with ventricular arrhythmia exortion in a cocaine abuser.
Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts.
No long-lasting or intermittent mast cell activation in acute coronary syndromes.
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population.
Myocardial Ischemia
Comparison of effects of ioxaglate versus iomeprol on histamine and tryptase release in patients with ischemic cardiomyopathy.
Myocarditis
Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis.
Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms.
Renin: at the heart of the mast cell.
Myositis
Mast cell tryptase causes homologous desensitization of beta-adrenoceptors by Ca2+ sensitization in tracheal smooth muscle.
Myxoma
A positive correlation between immunohistochemical expression of CD31 and mast cell tryptase in odontogenic tumors.
Nasal Obstruction
Chlorine inhalation produces nasal congestion in allergic rhinitics without mast cell degranulation.
Pathogenic mechanisms underlying the clinical symptoms of allergic rhinitis.
The effect of local hyperthermia on allergen-induced nasal congestion and mediator release.
Nasal Polyps
Allergic fungal sinusitis: an immunohistologic analysis.
Distribution, subtype population, and IgE positivity of mast cells in chronic rhinosinusitis with nasal polyps.
Effect of IFN-?2 on combined allergic rhinitis with nasal polyps.
Effect of nasal antifungal therapy on nasal cell activation markers in chronic rhinosinusitis.
Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue.
Measurement of inflammatory mediators of mast cells and eosinophils in native nasal lavage fluid in nasal polyposis.
Specific immunoglobulin E for staphylococcal enterotoxins in nasal polyps from patients with aspirin-intolerant asthma.
Specific inhibition of beta-tryptase expression in a human mast cell line by granulocyte-macrophage colony-stimulating factor produced by airways structural cells.
Nematode Infections
Functional relationships between sensory nerve fibers and mast cells of dura mater in normal and inflammatory conditions.
Neoplasm Metastasis
High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases.
Impact of stress and mast cells on brain metastases.
Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients.
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Mast cell tryptase promotes breast cancer migration and invasion.
Mast cells and cancer: a review of literature.
Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery.
Possible biological and translational significance of mast cells density in colorectal cancer.
Targeting mast cells in gastric cancer with special reference to bone metastases.
The release of tryptase from mast cells promote tumor cell metastasis via exosomes.
Neoplasm Micrometastasis
Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases.
Neoplasm, Residual
Quantitation of minimal residual disease in acute myeloid leukemia by tryptase monitoring identifies a group of patients with a high risk of relapse.
Neoplasms
A Prospective Observation of Psychological Distress in Patients With Anaphylaxis.
Activation of Cutaneous Immune Responses in Complex Regional Pain Syndrome.
Activation of ion secretion via proteinase-activated receptor-2 in human colon.
Acute basophilic leukemia in a child. Anaphylactoid reaction and coagulopathy secondary to vincristine-mediated degranulation.
Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut.
Amelioration of Enterotoxigenic Escherichia coli-Induced Intestinal Barrier Disruption by Low-Molecular-Weight Chitosan in Weaned Pigs is Related to Suppressed Intestinal Inflammation and Apoptosis.
American Academy of Asthma, Allergy & Immunology membership experience with venom immunotherapy in chronic medical conditions and pregnancy, and in young children.
Are testicular mast cells involved in the regulation of germ cells in man?
Association between mast cells of different phenotypes and angiogenesis in colorectal cancer.
Biochemical markers in the follow-up of medullary thyroid cancer.
Biological markers in nasal secretions.
Bivalent effect of UV light on human skin mast cells-low-level mediator release at baseline but potent suppression upon mast cell triggering.
Bone marrow mastocytosis associated with an undifferentiated extramedullary tumor of hemopoietic origin.
CD117 Is Not a Useful Marker for Diagnosing Atypical Fibroxanthoma.
Characterization of mast cells according to their content of tryptase and chymase in normal and neoplastic human uterine cervix.
Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining.
Comparative proteomic analysis between normal skin and keloid scar.
Correlation between serum tryptase, mast cells positive to tryptase and microvascular density in colo-rectal cancer patients: possible biological-clinical significance.
Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer.
Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression.
Decentralization of the superior cervical ganglia inhibits mast cell mediated TNF alpha-dependent cytotoxicity. 1. Potential role of salivary glands.
Deficits of urothelial cell proliferation, cytoskeleton, and barrier function protein expressions in patients with recurrent and persistent urinary tract infections.
Degranulating mast cells in fibrotic regions of human tumors and evidence that mast cell heparin interferes with the growth of tumor cells through a mechanism involving fibroblasts.
Demonstration of tryptase in bovine cutaneous and tumor mast cells.
Density of mast cells and microvessels in minor salivary gland tumors.
Density of Tryptase-Positive Mast Cells Correlated with the Presence of H. pylori in Gastric Neoplasia.
Detection of c-kit mutation Asp 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic leukaemia.
Detection of inflammatory markers in stools from patients with irritable bowel syndrome and collagenous colitis.
Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms.
Differences in the proteome of high-grade versus low-grade canine cutaneous mast cell tumours.
Different spatial distribution of inflammatory cells in the tumor microenvironment of ABC and GBC subgroups of diffuse large B cell lymphoma.
Early effect of boron neutron capture therapy mediated by boronophenylalanine (BPA-BNCT) on mast cells in premalignant tissue and tumors of the hamster cheek pouch.
Effect of the H1-antihistamine clemastine on PACAP38 induced migraine.
Effects of analgesic and surgical modality on immune response in colorectal cancer surgery.
Effects of RNA interference-induced tryptase down-regulation in P815 cells on IL-6 and TNF-alpha release of endothelial cells.
Elevated tryptase levels selectively cluster in myeloid neoplasms: a novel diagnostic approach and screen marker in clinical haematology.
Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression.
Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells.
Expression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications.
Expression of Mast Cell Proteases Correlates with Mast Cell Maturation and Angiogenesis during Tumor Progression.
Expression of mast cell tryptases in Hodgkin and Reed-Sternberg (HRS) cells.
Fat-free pleomorphic lipoma of the buccal mucosa: An immunohistochemical study and literature review.
Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells.
French maritime pine bark extract inhibits viral replication and prevents development of viral myocarditis.
Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man.
Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis.
High density of tryptase-positive mast cells in patients with renal cell carcinoma on hemodialysis: correlation with expression of stem cell factor and protease activated receptor-2.
High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases.
IL-11 inhibits Clostridium difficile toxin A enterotoxicity in rat ileum.
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Immunohistochemical characterization of mast cell disease in paraffin sections using tryptase, CD68, myeloperoxidase, lysozyme, and CD20 antibodies.
Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma.
Immunosurveillance function of human mast cell?
Importance of Adequate Diagnostic Workup for Correct Diagnosis of Advanced Systemic Mastocytosis.
Increase of mast cells and tumor angiogenesis in oral squamous cell carcinoma.
Infiltrating cells, related cytokines and chemokine receptors in lesional skin of patients with dermatomyositis.
Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients.
Inflammatory cells in node-negative breast cancer.
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis.
Intestinal granular cells of a cartilaginous fish, thornback ray Raja clavata: Morphological characterization and expression of different molecules.
Intratumoral and Peritumoral Mast Cells in Malignant Melanoma: An Immunohistochemical Study.
Kaempferol ameliorates secretagogue-induced pseudo-allergic reactions via inhibiting intracellular calcium fluctuation.
Low Intratumoral Mast Cells Are Associated With a Higher Risk of Prostate Cancer Recurrence.
Low-fat and fat-free spindle cell lipomas in the oral cavity: Immunohistochemical analysis and review of the literature.
Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells.
Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat.
Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.
Mast cell chymase promotes angiogenesis and lymphangiogenesis mediated by activation of melanoma inhibitory activity gene family members in oral squamous cell carcinoma.
Mast cell density is associated with angiogenesis and poor prognosis in pulmonary adenocarcinoma.
Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer.
Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma.
Mast cell leukemia associated with undefined morphology and chronic basophilic leukemia.
Mast cell phenotype in benign and malignant tumors of the prostate.
Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically.
Mast cell sarcoma with tissue eosinophilia arising in the ascending colon.
Mast Cell Tryptase Contributes to Pancreatic Cancer Growth through Promoting Angiogenesis via Activation of Angiopoietin-1.
Mast cell tryptase promotes breast cancer migration and invasion.
Mast cell tumors of the gastrointestinal tract in 39 dogs.
Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection.
Mast cells and cancer: a review of literature.
Mast cells density positive to tryptase correlates with angiogenesis in pancreatic ductal adenocarcinoma patients having undergone surgery.
Mast cells express functional CD30 ligand and are the predominant CD30L-positive cells in Hodgkin's disease.
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Mast Cells in Human Cutaneous Neurofibromas: Density, Subtypes, and Association with Clinical Features in Neurofibromatosis 1.
Mast cells in human digestive tube in normal and pathological conditions.
Mast Cells in Liver Disease Progression: An Update on Current Studies and Implications.
Mast cells mediate malignant pleural effusion formation.
Mast cells or not? - CD117 positive cells in esophageal leiomyoma.
Mast Cells Positive for c-Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue.
Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated.
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Mediators and cytokines in persistent allergic rhinitis and nonallergic rhinitis with eosinophilia syndrome.
Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma.
Murine mast cell lines as indicators of early events in mast cell and basophil development.
Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva.
Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma.
Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer.
Neuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis: Diagnostic study.
Nucleoside 5'-O-monophosphorothioates as modulators of the P2Y14 receptor and mast cell degranulation.
Paraffin section immunophenotype of cutaneous and extracutaneous mast cell disease: comparison to other hematopoietic neoplasms.
Possible biological and translational significance of mast cells density in colorectal cancer.
Potential role of mast cells in hamster cheek pouch carcinogenesis.
Preliminary evaluation of mast cells in rats with an experimental fibrosarcoma induced by 3-methylcholanthrene.
Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer.
Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis.
Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.
Protective role of mouse mast cell tryptase Mcpt6 in melanoma.
Quantitative analysis of tryptase and chymase containing mast cells in benign and malignant breast lesions.
Recent Trends in the Design, Synthesis and Biological Exploration of ?-Lactams.
Role of Mast Cells in Shaping the Tumor Microenvironment.
Segmental allergen challenge induces plasma protein leakage into the airways of asthmatic subjects at 4 hours but not at 5 minutes after challenge.
Serglycin--structure and biology.
Serum level of mast cell tryptase in patients with oral squamous cell carcinoma: lack of correlation with clinicopathologic factors.
Serum tryptase, mast cells positive to tryptase and microvascular density evaluation in early breast cancer patients: possible translational significance.
Solitary mastocytoma of the vulva: report of a case.
Soluble Fc?RI, IgE, and tryptase as potential biomarkers of rapid desensitizations for platin IgE sensitized cancer patients.
Stabilizing mast cells improves acute lung injury after orthotopic liver transplantation via promotion of apoptosis in polymorphonuclear neutrophils.
Structural examination of tryptase- and chymase-positive mast cells in livers, containing metastases from gastrointestinal cancers.
Successful treatment of KIT D816V-positive, imatinib-resistant systemic mastocytosis with interferon-alpha.
Survey of Mast Cell Density in Transitional Cell Carcinoma.
Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line.
Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: a histopathological challenge.
T cells, mast cells and microvascular density in diffuse large B cell lymphoma.
T-cell lymphoma with eosinophilic infiltration involving the intestinal tract in 11 dogs.
Targeting mast cells in gastric cancer with special reference to bone metastases.
Targeting mast cells tryptase in tumor microenvironment: a potential antiangiogenetic strategy.
The differentiation and function of myofibroblasts is regulated by mast cell mediators.
The effects of S1319, a novel marine sponge-derived beta2-adrenoceptor agonist, on IgE-mediated activation of human cultured mast cells.
The Molecular Aspect of Antitumor Effects of Protease Inhibitor Nafamostat Mesylate and Its Role in Potential Clinical Applications.
The production of collagen and the activity of mast-cell chymase increase in human skin after irradiation therapy.
The relationship between breast cancer molecular subtypes and mast cell populations in tumor microenvironment.
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
The release of tryptase from mast cells promote tumor cell metastasis via exosomes.
The role of lymphocytes, granulocytes, mast cells and their related cytokines in lesional skin of linear IgA bullous dermatosis.
The Role of Mast Cell Specific Chymases and Tryptases in Tumor Angiogenesis.
The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix.
The role of mast cell tryptases in cardiac myxoma: Histogenesis and development of a challenging tumor.
The Role of Mast Cells in IgE-Independent Lung Diseases.
The serum tryptase test: an emerging robust biomarker in clinical hematology.
The use of KIT and tryptase expression patterns as prognostic tools for canine cutaneous mast cell tumors.
Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-alpha, IL-6 and IL-1 beta: possible relevance to multiple sclerosis.
Tryptase inhibitors: a patent review.
Tryptase mast cells in malignant pleural mesothelioma as an independent favorable prognostic factor.
Tryptase Positivity in Chronic Myeloid Leukemia With Marked Basophilia.
Tryptase promotes breast cancer angiogenesis through PAR-2 mediated endothelial progenitor cell activation.
Tryptase serum levels in patients suffering from hepatocellular carcinoma undergoing intra-arterial chemoembolization: Possible predictive role of response to treatment.
Tryptase, a novel angiogenic factor stored in mast cell granules.
Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients.
Tumour necrosis factor stimulates human skin mast cells to release histamine and tryptase.
VEGF expression in dog mastocytoma.
Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome.
[Association of bone marrow mastocytosis with extremely immature extramedullary mast cell sarcoma]
[Epinephrine combined with acupuncture therapy can treat anaphylactic shock mice through nuclear factor-?B signaling pathway: a rat experimental result].
Neoplasms, Germ Cell and Embryonal
Are testicular mast cells involved in the regulation of germ cells in man?
Nephritis
Contribution of mast cells to the tubulointerstitial lesions in IgA nephritis.
Neurofibroma
Hyalinized Neurofibromas: Not Just Rare Variants in Skin of the Female Breast.
Neurogenic Inflammation
Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.
Cutaneous neurogenic inflammation in the sensitized acupoints induced by gastric mucosal injury in rats.
Mast cell tryptase and chymase are potential regulators of neurogenic inflammation in psoriatic skin.
Mast cell tryptase in dermal neurogenic inflammation.
Potentiation of the P2X3 ATP receptor by PAR-2 in rat dorsal root ganglia neurons, through protein kinase-dependent mechanisms, contributes to inflammatory pain.
Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa.
Role of mast cells and sensory nerves in skin inflammation.
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.
Neuroinflammatory Diseases
Inhibition of mast cell tryptase attenuates neuroinflammation via PAR-2/p38/NF?B pathway following asphyxial cardiac arrest in rats.
Nevus
Correlation of serum tryptase levels with total number of nevi, Breslow thickness, ulceration, and mitotic index in melanoma patients: evaluation of a promising prognostic marker.
Low numbers of tryptase+ and chymase+ mast cells associated with reduced survival and advanced tumor stage in melanoma.
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Skin Of Patients With Large/Giant Congenital Melanocytic Nevi Shows Increased Mast Cells.
Nose Diseases
Azelastine reduces mediators of inflammation in patients with nasal polyps.
Obesity
Determinants of serum tryptase in a general population: the relationship of serum tryptase to obesity and asthma.
Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study.
Involvement of mast cells in adipose tissue fibrosis.
Mast cell stabilization: novel medication for obesity and diabetes.
Mast cells are not associated with systemic insulin resistance.
Odontogenic Cysts
Mast cell-derived tryptase in odontogenic cysts.
Relationship between mast cells and E-cadherin in odontogenic keratocysts and radicular cysts.
Odontogenic Tumors
A positive correlation between immunohistochemical expression of CD31 and mast cell tryptase in odontogenic tumors.
Oligospermia
Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells.
Significance of mast cells in spermatogenesis, implantation, pregnancy, and abortion: Cross talk and molecular mechanisms.
Onchocerciasis
Association of transient dermal mastocytosis and elevated plasma tryptase levels with development of adverse reactions after treatment of onchocerciasis with ivermectin.
Mast cells in onchocercomas from patients with hyperreactive onchocerciasis (sowda).
Oral Submucous Fibrosis
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
Orchitis
Development of testicular inflammation in the rat involves activation of proteinase-activated receptor-2.
Osteoarthritis
Cellular activation products in osteoarthritis synovial fluid.
Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis.
Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee.
Mast cell activation in arthritis: detection of alpha- and beta-tryptase, histamine and eosinophil cationic protein in synovial fluid.
Mast cell responses in rheumatoid synovium. Association of the MCTC subset with matrix turnover and clinical progression.
Release of mast cell mediators and nitrites into knee joint fluid in osteoarthritis--comparison with articular chondrocalcinosis and rheumatoid arthritis.
Tryptase is a candidate autoantigen in rheumatoid arthritis.
Osteoarthritis, Knee
Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee.
Osteolysis
Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants.
Osteoporosis
Bone Marrow Mastocytosis: A Diagnostic Challenge.
Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis.
Clinical aspects of paediatric mastocytosis: a review of 101 cases.
Epidemiology, prognosis, and risk factors in mastocytosis.
Mast cell-derived tryptase in odontogenic cysts.
Mastocytosis with urticaria pigmentosa and osteoporosis.
Mastocytosis: the puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease.
Systemic mastocytosis: a rare cause of osteoporosis.
Systemic mastocytosis: current concepts and treatment advances.
Osteosclerosis
Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis.
Otitis Media
Expression of mast cell tryptase in pediatric otitis media with effusion.
Mast cells and tryptase in the middle ear of children with otitis media with effusion.
Otitis Media with Effusion
Evidence of mast cell activity in the middle ears of children with otitis media with effusion.
Expression of mast cell tryptase in pediatric otitis media with effusion.
Mast cells and tryptase in the middle ear of children with otitis media with effusion.
Overweight
Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects.
Effect of body mass index and rocuronium on serum tryptase concentration during volatile general anesthesia: an observational study.
Factors influencing serum total tryptase concentrations in a general adult population.
Increase in Tryptase and Its Role in the Synovial Membrane of Overweight and Obese Patients with Osteoarthritis of the Knee.
Pancreatic Diseases
Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression.
Pancreatic Neoplasms
Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression.
Mast Cell Tryptase Contributes to Pancreatic Cancer Growth through Promoting Angiogenesis via Activation of Angiopoietin-1.
Mast cells and angiogenesis in pancreatic ductal adenocarcinoma.
Mast cells density positive to tryptase correlates with angiogenesis in pancreatic ductal adenocarcinoma patients having undergone surgery.
Mast Cells Positive for c-Kit Receptor and Tryptase Correlate with Angiogenesis in Cancerous and Adjacent Normal Pancreatic Tissue.
The stem cell factor-c-kit system and mast cells in human pancreatic cancer.
Pancreatitis
Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis.
Protease-activated receptor-2-mediated proliferation and collagen production of rat pancreatic stellate cells.
Serum levels of mast cell tryptase, vascular endothelial growth factor and basic fibroblast growth factor in patients with acute pancreatitis.
Serum levels of mast cell tryptase, vascular endothelial growth factor, and basic fibroblast growth factor in patients with acute pancreatitis.
Pancytopenia
Hyperfibrinolysis in a case of myelodysplastic syndrome with leukemic spread of mast cells.
KIT D816V Positive Acute Mast Cell Leukemia Associated with Normal Karyotype Acute Myeloid Leukemia.
Parasitic Diseases
Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
Mouse Mast Cell Tryptase mMCP-6 Is a Critical Link between Adaptive and Innate Immunity in the Chronic Phase of Trichinella spiralis Infection.
Pemphigoid, Bullous
Increased tryptase and myeloperoxidase levels in blister fluids of patients with bullous pemphigoid: correlations with cytokines, adhesion molecules and anti-basement membrane zone antibodies.
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Pemphigus
Further support for a role for Th2-like cytokines in blister formation of pemphigus.
Peptic Ulcer
Are tryptase and cathepsin D related to Helicobacter pylori infection and mucosal gastrin in peptic ulcer?
Influence of Helicobacter pylori on tryptase and cathepsin D in peptic ulcer.
Periapical Diseases
Expression of transforming growth factor-? in mast cells in human chronic periapical diseases.
Periapical Granuloma
Immunoexpression of tryptase-positive mast cells in periapical granulomas and radicular cysts.
Periodontal Diseases
Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases.
Periodontitis
Mast Cells in the Periodontal Disease of Non-HIV-Infected and HIV-Infected Individuals Undergoing Highly Active Antiretroviral Therapy.
Matrix metalloproteinases and their inhibitors in gingival mast cells in persons with and without human immunodeficiency virus infection.
Nafamostat mesilate, a potent tryptase inhibitor, modulates periodontitis in rats.
Peripheral Vascular Diseases
Mast cell subpopulations in the synovial tissue of patients with osteoarthritis: selective increase in numbers of tryptase-positive, chymase-negative mast cells.
Peritonitis
Induction of a selective and persistent extravasation of neutrophils into the peritoneal cavity by tryptase mouse mast cell protease 6.
Phyllodes Tumor
Expression of c-kit in fibroepithelial lesions of the breast is a mast cell phenomenon.
Plasmacytoma
Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors.
Introns excised from immunoglobulin pre-mRNAs exist as discrete species.
Purification and properties of a single strand-specific endonuclease from mouse cell mitochondria.
Pneumonia
A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice.
Correction to: A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice.
Mast cells in bronchiectasis.
Mast cells in bronchiolitis obliterans organizing pneumonia. Mast cell hyperplasia and evidence for extracellular release of tryptase.
Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia.
Pulmonary mastocytosis and enhanced lung inflammation in mice heterozygous null for the Foxf1 gene.
Polycythemia Vera
Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.
Polycythemia vera and water-induced pruritus: evidence against mast cell involvement.
Post-Cardiac Arrest Syndrome
[Dachengqi decoction reduces the serum levels of mast cell tryptase and inflammatory cytokines in rabbits with post-cardiac arrest syndrome].
Post-Exercise Hypotension
Correction to: Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.
Histamine, mast cell tryptase and post-exercise hypotension in healthy and collapsed marathon runners.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of mast cell tryptase by myeloblasts in a group of patients with acute myeloid leukemia.
[Tryptase relation to VEGF in acute leukemia]
Prediabetic State
Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients.
Pressure Ulcer
The 3G5 antigen is expressed in dermal mast cells but not pericytes.
Primary Dysautonomias
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Primary Myelofibrosis
Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.
Systemic mastocytosis: current concepts and treatment advances.
Tryptase Positivity in Chronic Myeloid Leukemia With Marked Basophilia.
Prostatic Neoplasms
High Extratumoral Mast Cell Counts Are Associated with a Higher Risk of Adverse Prostate Cancer Outcomes.
Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro.
Prostatitis
Tryptase - PAR2 axis in Experimental Autoimmune Prostatitis, a model for Chronic Pelvic Pain Syndrome.
Protein Deficiency
The effect of protein deficiency on systemic release of rat mucosal mast cell protease II during Nippostrongylus brasiliensis infection and following systemic anaphylaxis.
Proteinuria
Serum tryptase levels and markers of renal dysfunction in a population with chronic kidney disease.
Prurigo
Dendritic mast cells in prurigo nodularis skin.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Pruritus
A rare manifestation of indolent systemic mastocytosis and its management during the coronavirus disease 2019 pandemic; educational lessons from Syria.
Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus.
Effect of oral cromolyn sodium on CKD-associated pruritus and serum tryptase level: a double-blind placebo-controlled study.
Effective treatment of pruritus in atopic dermatitis using H1 antihistamines (second-generation antihistamines): changes in blood histamine and tryptase levels.
Efficacy of lodoxamide eye drops on mast cells and eosinophils after allergen challenge in allergic conjunctivitis.
Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number.
Increased levels of palmitoylethanolamide and other bioactive lipid mediators and enhanced local mast cell proliferation in canine atopic dermatitis.
Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs.
Lysophosphatidic acid is a potential mediator of cholestatic pruritus.
Narrow-band UVB phototherapy and psoralen-ultraviolet A photochemotherapy in the treatment of cutaneous mastocytosis: a study in 20 patients.
Oral antihistamine therapy influences plasma tryptase levels in adult atopic dermatitis.
Pathogenic mechanisms underlying the clinical symptoms of allergic rhinitis.
Pediatric Mastocytosis: A Review of the Literature.
Polycythemia vera and water-induced pruritus: evidence against mast cell involvement.
Pruritus in selected dermatoses.
Systemic mastocytosis: current concepts and treatment advances.
Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin.
Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response.
[Sex Differences of the Inflammatory Mediator Level at the Time of Itch Onset in Patients with Chronic Venous Disease].
Psoriasis
Bivalent inhibition of human beta-tryptase.
Decreased chymase activity is associated with increased levels of protease inhibitors in mast cells of psoriatic lesions.
Dibasic inhibitors of human mast cell tryptase. Part 2: structure-activity relationships and requirements for potent activity.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Possible molecular mechanisms to account for the involvement of tryptase in the pathogenesis of psoriasis.
Potential Role of Cytochrome c and Tryptase in Psoriasis and Psoriatic Arthritis Pathogenesis: Focus on Resistance to Apoptosis and Oxidative Stress.
Preliminary study of the tryptase levels in the synovial fluid of patients with inflammatory arthritis.
Psoriasis patients have highly increased numbers of tryptase-positive mast cells in the duodenal stroma.
Serum mast cell tryptase is not a useful marker for disease severity in psoriasis or atopic dermatitis.
Serum tryptase levels in patients with psoriasis: a pilot study for a possible useful biomarker.
Pterygium
Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium.
[Pterygium and mast cells--mast cell number, phenotype, and localization of stem cell factor]
Pulmonary Disease, Chronic Obstructive
A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.
Association of mast cells with lung function in chronic obstructive pulmonary disease.
Cigarette smoke extract-treated mast cells promote alveolar macrophage infiltration and polarization in experimental chronic obstructive pulmonary disease.
Evidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease.
Expression of Inflammatory Mediators in Induced Sputum: Comparative Study in Asthma and COPD.
Importance of mast cell Prss31/transmembrane tryptase/tryptase-? in lung function and experimental chronic obstructive pulmonary disease and colitis.
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2.
Mast cells in COPD airways: relationship to bronchodilator responsiveness and angiogenesis.
Plasma protein leakage and local secretion of proteins assessed in sputum in asthma and COPD. The effect of inhaled corticosteroids.
Protease-activated receptor-2 (PAR2) in the airways.
Pyrrole carboxamidine tryptase inhibitors from Leptonychia pubescens.
Sputum Gene Expression Reveals Dysregulation of Mast Cells and Basophils in Eosinophilic COPD.
Tryptase enzyme activity is correlated with severity of chronic obstructive pulmonary disease.
[Correlations between chymase activity ,levels of tryptase, and eotaxin in the sputum of patients with chronic obstructive puhnonary disease and their clinical implications]
Pulmonary Embolism
Use of enoximone in management of anaphylaxis complicated by labetalol use.
Pulmonary Eosinophilia
Clinical implications of correlation between peripheral eosinophil count and serum levels of IL-5 and tryptase in acute eosinophilic pneumonia.
Tryptase concentrations in bronchoalveolar lavage from patients with chronic eosinophilic pneumonia.
Pulmonary Fibrosis
Mast cell tryptase stimulates human lung fibroblast proliferation via protease-activated receptor-2.
Tryptase is involved in the development of early ventilator-induced pulmonary fibrosis in sepsis-induced lung injury.
Q Fever
Progenitor mast cells and tryptase in Q fever.
Radicular Cyst
Comparative immunohistochemical study of the presence of mast cells in apical granulomas and periapical cysts: possible role of mast cells in the course of human periapical lesions.
Immunoexpression of tryptase-positive mast cells in periapical granulomas and radicular cysts.
Relationship between mast cells and E-cadherin in odontogenic keratocysts and radicular cysts.
Renal Insufficiency, Chronic
Refractory intraoperative hypotension with elevated serum tryptase.
Serum tryptase concentration and progression to end-stage renal disease.
Serum tryptase levels and markers of renal dysfunction in a population with chronic kidney disease.
Tryptase is not cleared by the kidneys into the urine.
Reperfusion Injury
Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation.
Inhibiting tryptase after ischemia limits small intestinal ischemia-reperfusion injury through protease-activated receptor 2 in rats.
Intestinal mucosal injury induced by tryptase-activated protease-activated receptor 2 requires ?-arrestin-2 in vitro.
Respiratory Insufficiency
Beta-tryptase and quantitative mast-cell increase in a sudden infant death following hexavalent immunization.
Retinal Detachment
Involvement of premacular mast cells in the pathogenesis of macular diseases.
The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes.
Retinal Neovascularization
Mast cell hyperactivity underpins the development of oxygen-induced retinopathy.
Retinal Perforations
Involvement of premacular mast cells in the pathogenesis of macular diseases.
Long-term evaluation of spontaneous release of epiretinal membrane and its possible pathogenesis.
The role of tryptase and anti-type II collagen antibodies in the pathogenesis of idiopathic epiretinal membranes.
[The pathogenesis of vitreoretinal diseases from the standpoint of molecular biology]
Rhinitis
Airway inflammation in asthma and perennial allergic rhinitis. Relationship with nonspecific bronchial responsiveness and maximal airway narrowing.
Altered Expression of IFN-?2 in Allergic Airway Disorders and Identification of Its Cell Origins.
Chemokines in seasonal allergic rhinitis.
Eosinophil cationic protein (ECP) and tryptase in the nasal lavage fluid (NLF) of children with grass pollen rhinitis: levocabastine effect.
Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children.
Inhibitors of tryptase for the treatment of mast cell-mediated diseases.
Occupational asthma and rhinitis due to glutaraldehyde: changes in nasal lavage fluid after specific inhalatory challenge test.
Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa.
Purine derivatives in the study of allergic inflammation in respiratory diseases.
Relationship between nasal hyperreactivity, mediators and eosinophils in patients with perennial allergic rhinitis and controls.
Serum tryptase in allergic rhinitis: effect of cetirizine treatment.
The role of allergic rhinitis in nasal responses to sudden temperature changes.
Rhinitis, Allergic
Altered Expression of IFN-?2 in Allergic Airway Disorders and Identification of Its Cell Origins.
An ultrasensitive electrochemical detection of tryptase using 3D macroporous reduced graphene oxide nanocomposites by one-pot electrochemical synthesis.
Antihistamines: topical vs oral administration.
Chemokines in seasonal allergic rhinitis.
Development of a new, more sensitive immunoassay for human tryptase: use in systemic anaphylaxis.
Effect of IFN-?2 on combined allergic rhinitis with nasal polyps.
Elevated bronchoalveolar lavage fluid histamine levels in allergic asthmatics are associated with increased airway obstruction.
Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators.
Inducible nitric oxide synthase plays important roles in allergic reactions of pollinosis in mice sensitized with pollen allergy.
Local allergic rhinitis: a new entity, characterization and further studies.
Local allergic rhinitis: concept, clinical manifestations, and diagnostic approach.
Loratadine reduces allergen-induced mucosal output of alpha 2-macroglobulin and tryptase in allergic rhinitis.
Measurement of Tryptase and CC16/Albumin in Nasal Lavage Fluid as a Screening Tool of Allergic Rhinitis.
Mediators and cytokines in allergic and viral-triggered rhinitis.
Nerve growth factor localization in the nasal mucosa of patients with persistent allergic rhinitis.
Pavlovian conditioning of nasal tryptase release in human subjects with allergic rhinitis.
Preformed enzymes in mast cell granules and their potential role in allergic rhinitis.
Prevention of Allergic Rhinitis by Aldose Reductase Inhibition in a Murine Model.
Serum tryptase in allergic rhinitis: effect of cetirizine and fluticasone propionate treatment.
Serum tryptase in allergic rhinitis: effect of cetirizine treatment.
The effect of short-term immunotherapy with molecular standardized grass and rye allergens on eosinophil cationic protein and tryptase in nasal secretions.
TNF alpha is localized to nasal mucosal mast cells and is released in acute allergic rhinitis.
Tryptase in nasal fluid is a useful marker of allergic rhinitis.
Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response.
[Diagnosis of allergic rhinitis by determining of tryptase and eosinophil cationic protein in nasal secretions]
[Differentiation and proliferation of mast cells in nasal mucosa]
[Humoral mucosal immunity in allergic rhinitis]
[Levels of interleukin-4, interleukin-5, tryptase and eosinophil cationic protein of nasal lavage fluid in pollen allergic rhinitis]
[Tryptase determination in nasal washings in patients with allergic rhinitis]
Rhinitis, Allergic, Seasonal
Inducible nitric oxide synthase plays important roles in allergic reactions of pollinosis in mice sensitized with pollen allergy.
Loratadine reduces allergen-induced mucosal output of alpha 2-macroglobulin and tryptase in allergic rhinitis.
Sarcoidosis
Elevated levels of tryptase in bronchoalveolar lavage fluid from patients with sarcoidosis.
Mast cell tryptase and histamine concentrations in bronchoalveolar lavage fluid from patients with interstitial lung disease.
The analysis of tryptase in serum of sarcoidosis patients.
[The clinical significance of mast cell tryptase in bronchial alveolar lavage fluid in interstitial lung diseases]
Sarcoma, Kaposi
Mast cell "densities" in vascular proliferations: a preliminary study of pyogenic granuloma, portwine stain, cavernous hemangioma, cherry angioma, Kaposi's sarcoma, and malignant hemangioendothelioma.
Mast cells in cutaneous tumors: innocent bystander or maestro conductor?
Schistosomiasis mansoni
Temporal distribution of distinct mast cell phenotypes during intestinal schistosomiasis in mice.
Sepsis
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Severe Dengue
Alpha tryptase allele of Tryptase 1 (TPSAB1) gene associated with Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) in Vietnam and Philippines.
Host genetics and dengue fever.
Shock, Cardiogenic
Mast cell tryptase: a review of its physiology and clinical significance.
Sialadenitis
Immunohistochemical study of fibroblasts and mast cells in chronic submandibular sialadenitis.
Silicosis
Mast cell basic fibroblast growth factor in silicosis.
Sinusitis
Allergic fungal sinusitis: an immunohistologic analysis.
Elevated Tryptase in EoE Is an Independent Phenomenon Associated with Extra-Esophageal Symptoms.
Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells.
Skin Diseases
Induction of C3 and CCL2 by C3a in Keratinocytes: A Novel Autocrine Amplification Loop of Inflammatory Skin Reactions.
Mast cells in developing subepidermal bullous diseases: emphasis on tryptase, chymase and protease inhibitors.
Skin Neoplasms
Association of Elevated Serum Tryptase with Cutaneous Photodamage and Skin Cancers.
Smooth Muscle Tumor
Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells.
Spasm
[Tryptase levels are elevated during spontaneous ischemic episodes in unstable angina but not after the ergonovine test in variant angina]
Spinal Cord Injuries
Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6.
Squamous Cell Carcinoma of Head and Neck
Altered immunohistochemical expression of mast cell tryptase and chymase in the pathogenesis of oral submucous fibrosis and malignant transformation of the overlying epithelium.
Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma.
Serum level of mast cell tryptase in patients with oral squamous cell carcinoma: lack of correlation with clinicopathologic factors.
ST Elevation Myocardial Infarction
Dynamic changes and clinical significance of serum tryptase levels in STEMI patients treated with primary PCI.
Elevated Serum Tryptase and Endothelin in Patients with ST Segment Elevation Myocardial Infarction: Preliminary Report.
Starvation
Copper Regulates Maturation and Expression of an MITF:Tryptase Axis in Mast Cells.
Phenotypic characterization of KU812, a cell line identified as an immature human basophilic leukocyte.
Stomach Neoplasms
Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer.
Infiltrating mast cells correlate with angiogenesis in bone metastases from gastric cancer patients.
Intratumor IL-17-positive mast cells are the major source of the IL-17 that is predictive of survival in gastric cancer patients.
Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically.
Mast Cells Density Positive to Tryptase Correlate with Microvascular Density in both Primary Gastric Cancer Tissue and Loco-Regional Lymph Node Metastases from Patients That Have Undergone Radical Surgery.
Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated.
Tryptase expression as a prognostic marker in patients with resected gastric cancer.
Tryptase mast cell density, protease-activated receptor-2 microvascular density, and classical microvascular density evaluation in gastric cancer patients undergoing surgery: possible translational relevance.
Tumor-Associated Macrophages and Mast Cells Positive to Tryptase Are Correlated with Angiogenesis in Surgically-Treated Gastric Cancer Patients.
Stomach Ulcer
Increase of mast cells may be associated with infiltration of eosinophils and proliferation of microvessels in gastric eosinophilic granuloma.
Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease.
[Alcohol-dependent mast cell activation in ulcer]
Stupor
Anaphylaxis should be considered to be a potential cause of stuporous state.
Synovitis
Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis.
Expression of the alphaEbeta7 integrin by mast cells in rheumatoid synovium.
Tachycardia
Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia.
Tendinopathy
Protease-activated receptors in the Achilles tendon-a potential explanation for the excessive pain signalling in tendinopathy.
Thrombocythemia, Essential
Mast cell burden and reticulin fibrosis in the myeloproliferative neoplasms: a computer-assisted image analysis study.
Thrombosis
Anaphylactic cardiovascular collapse and Kounis syndrome: systemic vasodilation or coronary vasoconstriction?
Immunoglobulin E, mast cell-specific tryptase and the complement system in sudden death from coronary artery thrombosis.
Inactivation of human high molecular weight kininogen by human mast cell tryptase.
Mast cell distribution, activation, and phenotype in atherosclerotic lesions of human carotid arteries.
Protease-activated receptor 2 signaling in inflammation.
The molecular role of mast cells in atherosclerotic cardiovascular disease.
Thyroid Cancer, Papillary
Higher intratumoral expression of CD1a, tryptase, and CD68 in a follicular variant of papillary thyroid carcinoma compared to adenomas: correlation with clinical and pathological parameters.
Trauma, Nervous System
Mast cells as protectors of health.
tryptase deficiency
Genetic deficiency of human mast cell alpha-tryptase.
Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation.
Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease.
The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells.
Urinary Bladder Neoplasms
Elevated tryptase, nerve growth factor, neurotrophin-3 and glial cell line-derived neurotrophic factor levels in the urine of interstitial cystitis and bladder cancer patients.
Urinary Bladder, Overactive
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome.
Urticaria
An unusual case of systemic mastocytosis associated with chronic lymphocytic leukaemia (SM-CLL).
Chronic inducible urticaria subtypes in children: Clinical features and prognosis.
Cold Agglutinins and Cryoglobulins Associate With Clinical and Laboratory Parameters of Cold Urticaria.
Cutaneous manifestations in Hymenoptera and Diptera anaphylaxis: relationship with basal serum tryptase.
Diagnosis and management of anaphylaxis in precision medicine.
Elevated Tryptase in EoE Is an Independent Phenomenon Associated with Extra-Esophageal Symptoms.
Ethanol-induced urticaria: elevated tryptase levels after double-blind, placebo-controlled challenge.
Evaluation of the left venticular systolic function with the measurement of global longitudinal strain by Speckle tracking echocardiography in anaphylaxis.
Histamine and tryptase levels in patients with acute allergic reactions: An emergency department-based study.
Immunoglobulin E-bearing cells and mast cells in skin biopsies of horses with urticaria.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.
Mast cell number and phenotype in chronic idiopathic urticaria.
Predictors of severe anaphylaxis in Hymenoptera venom allergy: The importance of absence of urticaria and angioedema.
Serum total tryptase levels are increased in patients with active chronic urticaria.
Serum tryptase levels in adverse drug reactions.
Systemic mastocytosis: current concepts and treatment advances.
The Utility of Serum Tryptase as a Marker in Chronic Spontaneous Urticaria.
Ulcerative colitis patients with an inflammatory response upon mesalazine cannot be desensitized: a randomized study.
Usefulness of UniCAP-Tryptase fluoroimmunoassay in the diagnosis of anaphylaxis.
Urticaria Pigmentosa
Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis.
Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments.
Diagnostic value of immunostaining for tryptase in patients with mastocytosis.
Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis.
Increased tryptase levels in suction-blister fluid from patients with urticaria.
Mastocytosis with urticaria pigmentosa and osteoporosis.
Pediatric maculopapular cutaneous mastocytosis: Retrospective review of signs, symptoms, and associated conditions.
Serum tryptase measured with B12 and G5 antibody-based immunoassays in mastocytosis patients and its relation to histamine turnover.
Systemic mastocytosis: current concepts and treatment advances.
Treatment of three patients with systemic mastocytosis with interferon alpha-2b.
[Clinical variability in two cases of systemic mastocytosis]
Uterine Hemorrhage
Novel finding of high density of activated mast cells in endometrial polyps.
Varicocele
Significance of human testicular mast cells and their subtypes in male infertility.
Varicose Veins
Mast cell infiltration in the wall of varicose veins.
Vascular Diseases
Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases.
Effects of RNA interference-induced tryptase down-regulation in P815 cells on IL-6 and TNF-alpha release of endothelial cells.
Vascular System Injuries
Mast cell infiltration in the wall of varicose veins.
Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium.
Vasculitis
Mast cell tryptase and chymase in the progress of cutaneous vasculitis.
Mercuric chloride-induced vasculitis in the Brown Norway rat: alpha beta T cell-dependent and -independent phases: role of the mast cell.
Viremia
Dengue vascular leak syndrome: insights into potentially new treatment modalities.
Virus Diseases
Effects of rhinovirus-induced common colds on granulocyte activity in allergic rhinitis.
Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies.
Human mucus protease inhibitor in airway fluids is a potential defensive compound against infection with influenza A and Sendai viruses.
Mast cell tryptase from pig lungs triggers infection by pneumotropic Sendai and influenza A viruses. Purification and characterization.
Molecular basis of proteolytic activation of Sendai virus infection and the defensive compounds for infection.
Sendai virus infection changes the subcellular localization of tryptase Clara in rat bronchiolar epithelial cells.
The human mucus protease inhibitor and its mutants are novel defensive compounds against infection with influenza A and Sendai viruses.
Vulvodynia
Mast cell infiltrates in vulvodynia represent secondary and idiopathic mast cell hyperplasias.
Whooping Cough
Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2.
Induction of tryptase and histamine release from human colon mast cells by IgE dependent or independent mechanisms.
Mast cell tryptase is a mitogen for cultured fibroblasts.
Modulation of tryptase secretion from human colon mast cells by histamine.
Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway.
Xanthomatosis
Mast cell distribution, activation, and phenotype in xanthoma.
Overexpression of the CXCL3 gene in response to oxidized low-density lipoprotein is associated with the presence of tendon xanthomas in familial hypercholesterolemia.