Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.21.45 - complement factor I

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alzheimer Disease
A monoclonal antibody targeting amyloid ? (A?) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease.
Angioedema
The role of complement in urticaria and angioedema.
Arthritis, Rheumatoid
Alternative pathway complement activation in rheumatoid arthritis.
C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase.
Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and skynovial membrane cells from patients with rheumatoid arthritis.
Atypical Hemolytic Uremic Syndrome
A Newly Identified Mutation in the Complement Factor I Gene Not Associated With Early Post-transplant Recurrence of Atypical Hemolytic-Uremic Syndrome: A Case Report.
An extremely rare splice site mutation in the gene encoding complement factor I in a patient with atypical hemolytic uremic syndrome.
Atypical hemolytic-uremic syndrome due to complement factor I mutation.
Eculizumab for the treatment of an atypical hemolytic uremic syndrome with mutations in complement factor I and C3.
Excessive activation of the complement system in atypical hemolytic uremic syndrome: is it ready for prime time?
Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead either to altered secretion or altered function of factor I.
Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome.
Simultaneous acute pancreatitis and angioedema associated with angiotensin-converting enzyme inhibitor.
Bacterial Infections
Classical and Non-classical Presentations of Complement Factor I Deficiency: Two Contrasting Cases Diagnosed via Genetic and Genomic Methods.
[Hereditary complement deficiencies]
Breast Neoplasms
Local expression of complement factor I in breast cancer cells correlates with poor survival and recurrence.
Bronchiectasis
C3b inactivator deficiency with immune complex manifestations.
Carcinoma
Complement factor I promotes progression of cutaneous squamous cell carcinoma.
Carcinoma, Hepatocellular
Biosynthesis and postsynthetic processing of human C3b/C4b inactivator (factor I) in three hepatoma cell lines.
Carcinoma, Non-Small-Cell Lung
Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors.
Tag SNPs of CFI contributed to the susceptibility for non-small cell lung cancer in Chinese population.
Carcinoma, Squamous Cell
Complement factor I promotes progression of cutaneous squamous cell carcinoma.
Complement factor I upregulates expression of matrix metalloproteinase-13 and -2 and promotes invasion of cutaneous squamous carcinoma cells.
Choroidal Neovascularization
Evaluation of pigment epithelium-derived factor and complement factor I polymorphisms as a cause of choroidal neovascularization in highly myopic eyes.
Colitis, Ulcerative
Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.
complement factor i deficiency
A family with complement factor I deficiency.
C3b inactivator deficiency with immune complex manifestations.
Classical and Non-classical Presentations of Complement Factor I Deficiency: Two Contrasting Cases Diagnosed via Genetic and Genomic Methods.
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis.
Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation.
Complement factor I deficiency in a 3-year-old boy with glomerulonephritis.
Complement factor I deficiency in a family with recurrent infections.
Complement factor I deficiency with recurrent aseptic meningitis.
Complement factor I deficiency: a not so rare immune defect. characterization of new mutations and the first large gene deletion.
Complement factor I deficiency: A potentially treatable cause of fulminant cerebral inflammation.
Complement-activating ability of leucocytes from patients with complement factor I deficiency.
Control of serum C3 levels by beta 1H and C3b inactivator.
Early Versus Late Diagnosis of Complement Factor I Deficiency: Clinical Consequences Illustrated in Two Families with Novel Homozygous CFI Mutations.
Genetic, molecular and functional analyses of complement factor I deficiency.
Glomerulonephritis in a patient with complement factor I deficiency.
Hereditary complement factor I deficiency.
Molecular basis of complement factor I deficiency in Tunisian atypical hemolytic and uremic syndrome Patients.
Molecular characterization of Complement Factor I deficiency in two Spanish families.
Molecular characterization of two novel cases of complete complement inhibitor Factor I deficiency.
Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency.
Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency.
Primary Pneumococcal Peritonitis can be the first presentation of a familial complement factor I deficiency.
Recurrent infections in partial complement factor I deficiency: evaluation of three generations of a Brazilian family.
Restoration by purified C3b inactivator of complement-mediated function in vivo in a patient with C3b inactivator deficiency.
Simultaneous acute pancreatitis and angioedema associated with angiotensin-converting enzyme inhibitor.
The molecular basis of hereditary complement factor I deficiency.
[Complement factor I deficiency revealed by repeated systemic Streptococcus pneumoniae infection]
Crohn Disease
Complement inhibitors and immunoconglutinins in ulcerative colitis and Crohn's disease.
Diabetes Mellitus, Type 1
Complements in diabetes mellitus: activation of complement system evidenced by C3d elevation in IDDM.
Diabetes Mellitus, Type 2
Complements in diabetes mellitus: activation of complement system evidenced by C3d elevation in IDDM.
Complements in non-insulin-dependent diabetes mellitus with complications.
Geographic Atrophy
Association Between Growth of Geographic Atrophy and the Complement Factor I Locus.
Prevalence and phenotype associations of complement factor I mutations in geographic atrophy.
Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.
Glioma
A Candidate Prognostic Biomarker Complement Factor I Promotes Malignant Progression in Glioma.
Glomerulonephritis
C3 glomerulonephritis and thrombotic microangiopathy of renal allograft after pulmonary infection in a male with concomitant two complement factor I gene variations: a case report.
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis.
Complement factor I deficiency in a 3-year-old boy with glomerulonephritis.
Correlations between serum factor B and C3b inactivator levels in normal subjects and in patients with infections, nephrosis and hypocomplementaemic glomerulonephritis.
Evidence for glomerular modulation of complement activation.
Glomerulonephritis in a patient with complement factor I deficiency.
Modulation of the properdin amplification loop in membranoproliferative and other forms of glomerulonephritis.
Glomerulonephritis, Membranoproliferative
Control of complement activation in membranous and membranoproliferative glomerulonephritis.
Control of serum C3 levels by beta 1H and C3b inactivator.
Hearing Loss, Noise-Induced
Transcriptome characterization by RNA-Seq reveals the involvement of the complement components in noise-traumatized rat cochleae.
HELLP Syndrome
The genetics of the alternative pathway of complement in the pathogenesis of HELLP syndrome.
Hemolytic-Uremic Syndrome
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome.
Hereditary Complement Deficiency Diseases
Genetic, molecular and functional analyses of complement factor I deficiency.
Infections
C3 glomerulonephritis and thrombotic microangiopathy of renal allograft after pulmonary infection in a male with concomitant two complement factor I gene variations: a case report.
Clinical laboratory standard capillary protein electrophoresis alerted of a low C3 state and lead to the identification of a Factor I deficiency due to a novel homozygous mutation.
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis.
Complement factor I deficiency in a family with recurrent infections.
Correlations between serum factor B and C3b inactivator levels in normal subjects and in patients with infections, nephrosis and hypocomplementaemic glomerulonephritis.
Cutaneous Vasculitis and Recurrent Infection Caused by Deficiency in Complement Factor I.
Genetic, molecular and functional analyses of complement factor I deficiency.
Glomerulonephritis in a patient with complement factor I deficiency.
Molecular characterization and expression of complement factor I in Pelteobagrus vachellii during Aeromonas hydrophila infection.
Recurrent infections in partial complement factor I deficiency: evaluation of three generations of a Brazilian family.
The effect of substance(s) associated with malarial parasites on C3b inactivator.
[Complement factor I deficiency revealed by repeated systemic Streptococcus pneumoniae infection]
Joint Diseases
C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase.
Leukoencephalitis, Acute Hemorrhagic
Mutations of Complement Factor I and Potential Mechanisms of Neuroinflammation in Acute Hemorrhagic Leukoencephalitis.
Lung Neoplasms
Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors.
Tag SNPs of CFI contributed to the susceptibility for non-small cell lung cancer in Chinese population.
Lupus Erythematosus, Systemic
C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase.
Relative importance of C3b inactivator and beta 1H globulin in the modulation of the properdin amplification loop in systemic lupus erythematosus.
Serum complement factor I is associated with disease activity of systemic lupus erythematosus.
Lupus Nephritis
Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis.
Macular Degeneration
A monoclonal antibody targeting amyloid ? (A?) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease.
Additional evidence to support the role of a common variant near the complement factor I gene in susceptibility to age-related macular degeneration.
Age-related macular degeneration: Complement in action.
Association between complement factor I gene polymorphisms and the risk of age-related macular degeneration: a Meta-analysis of literature.
Association of polymorphisms of complement factor I rs141853578 (G119R) with age-related macular degeneration in Iranian population.
Common variant rs10033900 near the complement factor I gene is associated with age-related macular degeneration risk in Han Chinese population.
Complement factor I and age-related macular degeneration.
Complement Factor I Gene Polymorphism in a Turkish Age-Related Macular Degeneration Population.
Complement factor I polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a chinese population.
Functional Analysis of Rare Genetic Variants in Complement Factor I (CFI) using a Serum-Based Assay in Advanced Age-related Macular Degeneration.
Interactions among different genetic loci in age-related macular degeneration.
No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration.
Prevalence and phenotype associations of complement factor I mutations in geographic atrophy.
Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration.
Rare genetic variants in the CFI gene are associated with advanced age-related macular degeneration and commonly result in reduced serum factor I levels.
Support for the involvement of complement factor I in age-related macular degeneration.
[Association of single nucleotide polymorphism in complement factor I gene with age-related macular degeneration].
Malaria
C3b inactivator in normal mice and mice infected with Plasmodium berghei berghei.
Malnutrition
Control of serum C3 levels by beta 1H and C3b inactivator.
Measles
Antibody-independent activation of the alternative complement pathway by measles virus-infected cells.
Meningitis
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis.
Complement factor I deficiency associated with recurrent meningitis coinciding with menstruation.
Meningitis, Aseptic
Complement factor I deficiency with recurrent aseptic meningitis.
Meningococcal Infections
Meningococcal infection and proteolytic control.
Neoplasms
Complement factor I is upregulated in rat hepatocytes by interleukin-6 but not by interferon-gamma, interleukin-1beta, or tumor necrosis factor-alpha.
New perspectives on role of tumor microenvironment in progression of cutaneous squamous cell carcinoma.
Nephrosis
Correlations between serum factor B and C3b inactivator levels in normal subjects and in patients with infections, nephrosis and hypocomplementaemic glomerulonephritis.
Nephrotic Syndrome
Control of serum C3 levels by beta 1H and C3b inactivator.
Neuroinflammatory Diseases
Classical and Non-classical Presentations of Complement Factor I Deficiency: Two Contrasting Cases Diagnosed via Genetic and Genomic Methods.
Mutations of Complement Factor I and Potential Mechanisms of Neuroinflammation in Acute Hemorrhagic Leukoencephalitis.
Osteoarthritis
Alternative pathway complement activation in rheumatoid arthritis.
Expression of proteins in serum, synovial fluid, synovial membrane, and articular cartilage samples obtained from dogs with stifle joint osteoarthritis secondary to cranial cruciate ligament disease and dogs without stifle joint arthritis.
Ovarian Neoplasms
Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.
Parasitemia
The role in vivo of C3 and the C3b receptor in babesial infection in the rat.
Pemphigus
Demonstration of beta 1H globulin in pemphigus.
Peritonitis
Primary Pneumococcal Peritonitis can be the first presentation of a familial complement factor I deficiency.
Pneumococcal Infections
Classical and Non-classical Presentations of Complement Factor I Deficiency: Two Contrasting Cases Diagnosed via Genetic and Genomic Methods.
[Complement factor I deficiency revealed by repeated systemic Streptococcus pneumoniae infection]
Pneumonia
C3b inactivator deficiency with immune complex manifestations.
Pre-Eclampsia
Immunological studies on pre-eclampsia in Nigerian women.
Proteinuria
Factor B and C3b inactivator clearance in patients with proteinuria.
Reye Syndrome
Hypocomplementemia in Reye syndrome: relationship to disease stage, circulating immune complexes, and C3b amplification loop protein synthesis.
Rheumatic Diseases
C3b inactivator in the rheumatic diseases. Measurement by radial immunodiffusion and by inhibition of formation of properdin pathway C3 convertase.
Sepsis
Host defense against opportunist microorganisms following trauma. II. Changes in complement and immunoglobulins in patients with abdominal trauma and in septic patients without trauma.
Stomach Neoplasms
Down-regulated expression of complement factor I: a potential suppressive protein for gastric cancer identified by serum proteome analysis.
Thrombotic Microangiopathies
Atypical haemolytic uraemic syndrome: a case of rare genetic mutation.
C3 glomerulonephritis and thrombotic microangiopathy of renal allograft after pulmonary infection in a male with concomitant two complement factor I gene variations: a case report.
Complement Factor I Mutation May Contribute to Development of Thrombotic Microangiopathy in Lupus Nephritis.
Urticaria
The role of complement in urticaria and angioedema.
Uveitis
CFI-rs7356506 is a genetic protective factor for acute anterior uveitis in Chinese patients.
CFI-rs7356506 polymorphisms associated with Vogt-Koyanagi-Harada syndrome.
Vaccinia
Disabling complement regulatory activities of vaccinia virus complement control protein reduces vaccinia virus pathogenicity.
Vasculitis
Complement factor I deficiency associated with recurrent infections, vasculitis and immune complex glomerulonephritis.
Cutaneous Vasculitis and Recurrent Infection Caused by Deficiency in Complement Factor I.
Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency.