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Reference on EC 3.4.21.43 - classical-complement-pathway C3/C5 convertase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nagasawa, S.; Kobayashi, C.; Maki-Suzuki, T.; Yamashita, N.; Koyama, J.
Purification and characterization of the C3 convertase of the classical pathway of human complement system by size exclusion high-performance liquid chromatography
J. Biochem.
97
493-499
1985
Homo sapiens
Manually annotated by BRENDA team
Kerr, M.A.
The human complement system: assembly of the classical pathway C3 convertase
Biochem. J.
189
173-181
1980
Homo sapiens
Manually annotated by BRENDA team
Vogt, W.; Schmidt, G.; v.Buttlar, B.; Dieminger, L.
A new function of the activated third component of complement: binding to C5, an essential step for C5 activation
Immunology
34
29-40
1978
Homo sapiens
Manually annotated by BRENDA team
Porter, R.R.; Reid, K.B.M.
The biochemistry of complement
Nature
275
699-704
1978
Homo sapiens
Manually annotated by BRENDA team
Nicholson-Weller, A.; Burge, J.; Austen, F.
Purification from guinea pig erythrocyte stroma of a decay-accelerating factor for the classical C3 convertase, C4b2a
J. Immunol.
127
2035-2039
1978
Homo sapiens
Manually annotated by BRENDA team
Emmerling, M.R.; Spiegel, K.; Watson, M.D.
Inhibiting the formation of classical C3-convertase on the Alzheimer s beta-amyloid peptide
Immunopharmacology
38
101-109
1997
Homo sapiens
Manually annotated by BRENDA team
Sahu, A.; Rawal, N.; Pangburn, M.K.
Inhibition of complement by covalent attachment of rosmarinic acid to activated C3b
Biochem. Pharmacol.
57
1439-1446
1999
Homo sapiens
Manually annotated by BRENDA team
Bloch, E.F.; Rahbar, M.; Wright, A.K.; Patterson, A.M.; Souza, R.F.; Hammer, C.H.; Gaither, T.A.; Joiner, K.A.
Potassium cyanide protects Escherichia coli from complement killing by the inhibition of C3 convertase activity
Immunol. Invest.
22(2)
127-149
1993
Homo sapiens
-
Manually annotated by BRENDA team
Kerr, M.A.
The second component of human complement
Methods Enzymol.
80
54-64
1981
Homo sapiens
-
Manually annotated by BRENDA team
Fodor, W.L.; Rollins, S.A.; Guilmette, E.R.; Settler, E.; Squinto, S.P.
A novel bifunctional chimeric complement inhibitor that regulates C3 convertase and formation of the membrane attack complex
J. Immunol.
155
4135-4138
1995
Homo sapiens
Manually annotated by BRENDA team
Pangburn, M.K.; Rawal, N.
Structure and function of complement C5 convertase enzymes
Biochem. Soc. Trans.
30
1006-1010
2002
Homo sapiens
Manually annotated by BRENDA team
Rawal, N.; Pangburn, M.K.
Formation of high affinity C5 convertase of the classical pathway of complement
J. Biol. Chem.
278
38476-38483
2003
Homo sapiens
Manually annotated by BRENDA team
Kuttner-Kondo, L.A.; Dybvig, M.P.; Mitchell, L.M.; Muqim, N.; Atkinson, J.P.; Medof, M.E.; Hourcade, D.E.
A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases
J. Biol. Chem.
278
52386-52391
2003
Homo sapiens
Manually annotated by BRENDA team
Blom, A.M.; Zadura, A.F.; Villoutreix, B.O.; Dahlback, B.
Positively charged amino acids at the interface between alpha-chain CCP1 and CCP2 of C4BP are required for regulation of the classical C3-convertase
Mol. Immunol.
37
445-453
2000
Homo sapiens
Manually annotated by BRENDA team
Krych-Goldberg, M.; Hauhart, R.E.; Porzukowiak, T.; Atkinson, J.P.
Synergy between two active sites of human complement receptor type 1 (CD35) in complement regulation: implications for the structure of the classical pathway C3 convertase and generation of more potent inhibitors
J. Immunol.
175
4528-4535
2005
Homo sapiens
Manually annotated by BRENDA team
Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway
Int. Immunol.
19
141-149
2007
Homo sapiens
Manually annotated by BRENDA team
Leinhase, I.; Schmidt, O.I.; Thurman, J.M.; Hossini, A.M.; Rozanski, M.; Taha, M.E.; Scheffler, A.; John, T.; Smith, W.R.; Holers, V.M.; Stahel, P.F.
Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury
Exp. Neurol.
199
454-464
2006
Mus musculus
Manually annotated by BRENDA team
Mark, L.; Proctor, D.G.; Blackbourn, D.J.; Blom, A.M.; Spiller, O.B.
Separation of decay-accelerating and cofactor functional activities of Kaposis sarcoma-associated herpesvirus complement control protein using monoclonal antibodies
Immunology
123
228-238
2008
Homo sapiens
Manually annotated by BRENDA team
Kuttner-Kondo, L.; Hourcade, D.E.; Anderson, V.E.; Muqim, N.; Mitchell, L.; Soares, D.C.; Barlow, P.N.; Medof, M.E.
Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases
J. Biol. Chem.
282
18552-18562
2007
Homo sapiens
Manually annotated by BRENDA team
Wallis, R.; Dodds, A.W.; Mitchell, D.A.; Sim, R.B.; Reid, K.B.; Schwaeble, W.J.
Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway
J. Biol. Chem.
282
7844-7851
2007
Rattus norvegicus
Manually annotated by BRENDA team
Jongerius, I.; Koehl, J.; Pandey, M.K.; Ruyken, M.; van Kessel, K.P.; van Strijp, J.A.; Rooijakkers, S.H.
Staphylococcal complement evasion by various convertase-blocking molecules
J. Exp. Med.
204
2461-2471
2007
Homo sapiens
Manually annotated by BRENDA team
Spitzer, D.; Mitchell, L.M.; Atkinson, J.P.; Hourcade, D.E.
Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly
J. Immunol.
179
2600-2608
2007
Homo sapiens
Manually annotated by BRENDA team
Krishnan, V.; Xu, Y.; Macon, K.; Volanakis, J.E.; Narayana, S.V.
The crystal structure of C2a, the catalytic fragment of classical pathway C3 and C5 convertase of human complement
J. Mol. Biol.
367
224-233
2007
Homo sapiens
Manually annotated by BRENDA team
Spiller, O.B.; Mark, L.; Blue, C.E.; Proctor, D.G.; Aitken, J.A.; Blom, A.M.; Blackbourn, D.J.
Dissecting the regions of virion-associated Kaposis sarcoma-associated herpesvirus complement control protein required for complement regulation and cell binding
J. Virol.
80
4068-4078
2006
Homo sapiens
Manually annotated by BRENDA team
Milder, F.J.; Raaijmakers, H.C.; Vandeputte, M.D.; Schouten, A.; Huizinga, E.G.; Romijn, R.A.; Hemrika, W.; Roos, A.; Daha, M.R.; Gros, P.
Structure of complement component C2A: implications for convertase formation and substrate binding
Structure
14
1587-1597
2006
Homo sapiens
Manually annotated by BRENDA team
Krishnan, V.; Xu, Y.; Macon, K.; Volanakis, J.E.; Narayana, S.V.
The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation
Acta Crystallogr. Sect. D
65
266-274
2009
Homo sapiens
Manually annotated by BRENDA team
Rawal, N.; Rajagopalan, R.; Salvi, V.P.
Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement
J. Biol. Chem.
283
7853-7863
2008
Homo sapiens
Manually annotated by BRENDA team
Roumenina, L.T.; Jablonski, M.; Hue, C.; Blouin, J.; Dimitrov, J.D.; Dragon-Durey, M.A.; Cayla, M.; Fridman, W.H.; Macher, M.A.; Ribes, D.; Moulonguet, L.; Rostaing, L.; Satchell, S.C.; Mathieson, P.W.; Sautes-Fridman, C.; Loirat, C.; Regnier, C.H.; Halbwachs-Mecarelli, L.; Fremeaux-Bacchi, V.
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Blood
114
2837-2845
2009
Ovis aries
Manually annotated by BRENDA team
Banda, N.K.; Levitt, B.; Wood, A.K.; Takahashi, K.; Stahl, G.L.; Holers, V.M.; Arend, W.P.
Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro
Clin. Exp. Immunol.
159
100-108
2010
Mus musculus
Manually annotated by BRENDA team
Katschke, K.J.; Stawicki, S.; Yin, J.; Steffek, M.; Xi, H.; Sturgeon, L.; Hass, P.E.; Loyet, K.M.; Deforge, L.; Wu, Y.; van Lookeren Campagne, M.; Wiesmann, C.
Structural and functional analysis of a C3b-specific antibody that selectively inhibits the alternative pathway of complement
J. Biol. Chem.
284
10473-10479
2009
Homo sapiens
Manually annotated by BRENDA team
Rawal, N.; Rajagopalan, R.; Salvi, V.P.
Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)
Mol. Immunol.
46
2902-2910
2009
Ovis aries
Manually annotated by BRENDA team
Laursen, N.S.; Gordon, N.; Hermans, S.; Lorenz, N.; Jackson, N.; Wines, B.; Spillner, E.; Christensen, J.B.; Jensen, M.; Fredslund, F.; Bjerre, M.; Sottrup-Jensen, L.; Fraser, J.D.; Andersen, G.R.
Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus
Proc. Natl. Acad. Sci. USA
107
3681-3686
2010
Homo sapiens
Manually annotated by BRENDA team
Laursen, N.; Andersen, K.; Braren, I.; Spillner, E.; Sottrup-Jensen, L.; Andersen, G.
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex
EMBO J.
30
606-616
2011
Homo sapiens (P01031)
Manually annotated by BRENDA team
Luo, S.; Hartmann, A.; Dahse, H.; Skerka, C.; Zipfel, P.
Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3
J. Immunol.
185
2164-2173
2010
Homo sapiens
Manually annotated by BRENDA team
Braunschweig, A.; Jozsi, M.
Human pentraxin 3 binds to the complement regulator c4b-binding protein
PLoS ONE
6
e23991
2011
Homo sapiens
Manually annotated by BRENDA team
Ramos, T.N.; Darley, M.M.; Weckbach, S.; Stahel, P.F.; Tomlinson, S.; Barnum, S.R.
The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria
J. Biol. Chem.
287
24734-24738
2012
Mus musculus
Manually annotated by BRENDA team
Lee, M.; Guo, J.P.; McGeer, E.G.; McGeer, P.L.
Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages
Neurobiol. Aging
34
1451-1461
2013
Homo sapiens
Manually annotated by BRENDA team
Okroj, M.; Holmquist, E.; King, B.C.; Blom, A.M.
Functional analyses of complement convertases using C3 and C5-depleted sera
PLoS ONE
7
e47245
2012
Homo sapiens
Manually annotated by BRENDA team
Kim, H.; Meyer, K.; Di Bisceglie, A.M.; Ray, R.
Inhibition of C3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components
PLoS ONE
9
e101422
2014
Homo sapiens
Manually annotated by BRENDA team
Zwarthoff, S.A.; Berends, E.T.M.; Mol, S.; Ruyken, M.; Aerts, P.C.; Jozsi, M.; de Haas, C.J.C.; Rooijakkers, S.H.M.; Gorham, R.D.
Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models
Front. Immunol.
9
1691
2018
Homo sapiens
Manually annotated by BRENDA team
Fridkis-Hareli, M.; Storek, M.; Or, E.; Altman, R.; Katti, S.; Sun, F.; Peng, T.; Hunter, J.; Johnson, K.; Wang, Y.; Lundberg, A.S.; Mehta, G.; Banda, N.K.; Michael Holers, V.
The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models
Mol. Immunol.
105
150-164
2019
Homo sapiens
Manually annotated by BRENDA team