Reference on EC 3.4.21.42 - complement subcomponent C1s
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gal, P.; Zavodzky, P.
Structure and function of the serine-protease subcomponents of C1: protein engineering studies
Immunobiology
199
317-326
1998
Homo sapiens
Sim, R.B.; Porter, R.R.; Reid, K.B.M.; Gigli, I.
The structure and enzymic activities of the C1r and C1s subcomponents of C1, the first component of human serum complement
Biochem. J.
163
219-227
1977
Homo sapiens
Sim, R.; Arlaud, G.J.; Colomb, M.G.
Kinetics of reaction of human C1bar-inhibitor with the human complement system proteases C1rbar and C1sbar
Biochim. Biophys. Acta
612
433-449
1980
Homo sapiens
Sim, R.B.
The human complement system serine proteases C1bar and C1sbar and their proenzymes
Methods Enzymol.
80
26-42
1981
Homo sapiens
Nilsson, T.; Wiman, B.
Kinetics of the reaction between human C1-esterase inhibitor and C1r or C1s
Eur. J. Biochem.
129
663-667
1983
Homo sapiens
Reboul, A.; Bensa, J.C.; Colomb, M.G.
Characteristics of complement subcomponents C1r and C1s synthesized by Hep G2 cells
Biochem. J.
233
559-564
1986
Homo sapiens
Thielens, N.M.; Aude, C.A.; Lacroix, M.B.; Gagnon, J.; Arlaud, G.J.
Ca2+ binding properties and Ca2+-dependent interactions of the isolated NH2-terminal alpha fragments of human complement proteases C1rbar and C1sbar
J. Biol. Chem.
265
14469-14475
1990
Homo sapiens
Katz, Y.; Guterman, M.; Lahat, E.
Regulation of synthesis of complement proteins in HEp2 cells
Clin. Immunol. Immunopathol.
67
117-123
1993
Homo sapiens
Zavodszky, P.; Gal, P.; Cseh, S.; Schumaker, V.N.
Protein engineering studies on C1r and C1s
Behring Inst. Mitt.
93
103-114
1993
Homo sapiens
Gulati, P.; Lemercier, C.; Guc, D.; Lappin, D.; Whaley, K.
Regulation of the synthesis of C1 subcomponents and C1-inhibitor
Behring Inst. Mitt.
93
196-203
1993
Homo sapiens
Arlaud, G.J.; Thielens, N.M.
Human complement serine proteases C1r and C1s and their proenzymes
Methods Enzymol.
223
61-82
1993
Homo sapiens
Kam, C.M.; Oglesby, T.J.; Pangburn, M.K.; Volanakis, J.E.; Powers, J.C.
Substituted isocoumarins as inhibitors of complement serine proteases
J. Immunol.
149
163-168
1992
Homo sapiens
Loos, M.; Heinz, H.P.; Clas, F.
C1sbar-esterase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
527-536
1984
Homo sapiens
-
Morgan, P.H.; Nair, I.G.
Hydrolysis of a synthetic amide substrate by human C1 esterase (C1sbar)
J. Immunol.
119
19-25
1977
Homo sapiens
Sumi, H.; Muramatu, M.
Purification and partial characterization of human C1-esterase
Agric. Biol. Chem.
38
605-611
1974
Homo sapiens
-
Bing, D.H.
Purification of the first component of human complement and its subunit C1 esterase
Methods Enzymol.
34B
731-746
1974
Homo sapiens
Tsai, S.W.; Poon, P.H.; Schumaker, V.N.
Expression and characterization of a 159 amino acid, N-terminal fragment of human complement component C1s
Mol. Immunol.
34
1273-1280
1997
Homo sapiens
Sakiyama, H.; Nishida, M.; Sakai, N.; Nagino, K.; Miyatake, S.; Saito, T.
Site-directed mutagenesis of hamster complement C1s: characterization with an active form-specific antibody and possible involvement of cis in tumorgenicity
Int. J. Cancer
66
768-771
1996
Mesocricetus auratus
Skoog, M.T.; Mehdi, S.; Wiseman, J.S.; Bey, P.
The specificity of two proteinases that cleave adjacent to arginine, C1 esterase and acrosin, for peptide p-nitroanilide substrates
Biochim. Biophys. Acta
996
89-94
1989
Homo sapiens
O'Brien, G.; Quinsey, N.S.; Whisstock, J.C.; Pike, R.N.
Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates
Biochemistry
42
14939-14945
2003
Homo sapiens
Subasinghe, N.L.; Ali, F.; Illig, C.R.; Jonathan Rudolph, M.; Klein, S.; Khalil, E.; Soll, R.M.; Bone, R.F.; Spurlino, J.C.; DesJarlais, R.L.; Crysler, C.S.; Cummings, M.D.; Morris, P.E., Jr.; Kilpatrick, J.M.; Sudhakara Babu, Y.
A novel series of potent and selective small molecule inhibitors of the complement component C1s
Bioorg. Med. Chem. Lett.
14
3043-3047
2004
Homo sapiens
Gaboriaud, C.; Rossi, V.; Bally, I.; Arlaud, G.J.; Fontecilla-Camps, J.C.
Crystal structure of the catalytic domain of human complement C1s: a serine protease with a handle
EMBO J.
19
1755-1765
2000
Homo sapiens
Busby, W.H., Jr.; Nam, T.J.; Moralez, A.; Smith, C.; Jennings, M.; Clemmons, D.R.
The complement component C1s is the protease that accounts for cleavage of insulin-like growth factor-binding protein-5 in fibroblast medium
J. Biol. Chem.
275
37638-37644
2000
Homo sapiens
Buerke, M.; Schwertz, H.; Seitz, W.; Meyer, J.; Darius, H.
Novel small molecule inhibitor of C1s exerts cardioprotective effects in ischemia-reperfusion injury in rabbits
J. Immunol.
167
5375-5380
2001
Oryctolagus cuniculus, Homo sapiens
Harmat, V.; Gal, P.; Kardos, J.; Szilagyi, K.; Ambrus, G.; Vegh, B.; Naray-Szabo, G.; Zavodszky, P.
The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions
J. Mol. Biol.
342
1533-1546
2004
Homo sapiens
Rossi, V.; Teillet, F.; Thielens, N.M.; Bally, I.; Arlaud, G.J.
Functional characterization of complement proteases C1s/mannan-binding lectin-associated serine protease-2 (MASP-2) chimeras reveals the higher C4 recognition efficacy of the MASP-2 complement control protein modules
J. Biol. Chem.
280
41811-41818
2005
Homo sapiens
Kerr, F.K.; OBrien, G.; Quinsey, N.S.; Whisstock, J.C.; Boyd, S.; de la Banda, M.G.; Kaiserman, D.; Matthews, A.Y.; Bird, P.I.; Pike, R.N.
Elucidation of the substrate specificity of the C1s protease of the classical complement pathway
J. Biol. Chem.
280
39510-39514
2005
Homo sapiens
Bally, I.; Rossi, V.; Thielens, N.M.; Gaboriaud, C.; Arlaud, G.J.
Functional role of the linker between the complement control protein modules of complement protease C1s
J. Immunol.
175
4536-4542
2005
Homo sapiens
Gosalia, D.N.; Salisbury, C.M.; Ellman, J.A.; Diamond, S.L.
High throughput substrate specificity profiling of serine and cysteine proteases using solution-phase fluorogenic peptide microarrays
Mol. Cell. Proteomics
4
626-636
2005
Homo sapiens
Gaboriaud, C.; Thielens, N.M.; Gregory, L.A.; Rossi, V.; Fontecilla-Camps, J.C.; Arlaud, G.J.
Structure and activation of the C1 complex of complement: unraveling the puzzle
Trends Immunol.
25
368-373
2004
Homo sapiens
Travins, J.M.; Ali, F.; Huang, H.; Ballentine, S.K.; Khalil, E.; Hufnagel, H.R.; Pan, W.; Gushue, J.; Leonard, K.; Bone, R.F.; Soll, R.M.; DesJarlais, R.L.; Crysler, C.S.; Ninan, N.; Kirkpatrick, J.; Cummings, M.D.; Huebert, N.; Molloy, C.J.; Gaul, M.; Tomczuk, B.E.; Subasinghe, N.L.
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
Bioorg. Med. Chem. Lett.
18
1603-1606
2008
Rattus norvegicus
Kerr, F.K.; Thomas, A.R.; Wijeyewickrema, L.C.; Whisstock, J.C.; Boyd, S.E.; Kaiserman, D.; Matthews, A.Y.; Bird, P.I.; Thielens, N.M.; Rossi, V.; Pike, R.N.
Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor
Mol. Immunol.
45
670-677
2008
Homo sapiens
Boyd, S.E.; Kerr, F.K.; Albrecht, D.W.; de la Banda, M.G.; Ng, N.; Pike, R.N.
Cooperative effects in the substrate specificity of the complement protease C1s
Biol. Chem.
390
503-507
2009
unidentified
Arriaga, S.M.; Basiglio, C.L.; Mottino, A.D.; Almara, A.M.
Unconjugated bilirubin inhibits C1 esterase activity
Clin. Biochem.
42
919-921
2009
Homo sapiens
Birnbaum, J.; Klotz, E.; Spies, C.D.; Hein, O.V.; Mallin, K.; Kawka, R.; Ziemer, S.; Lehmann, C.
The combinations C1 esterase inhibitor with coagulation factor XIII and N-acetylcysteine with tirilazad mesylate reduce the leukocyte adherence in an experimental endotoxemia in rats
Clin. Hemorheol. Microcirc.
40
167-176
2008
Rattus norvegicus
Hong, S.B.; Kim, C.W.; Kim, J.H.; Kim, J.S.; Han, S.B.
A case of angioedema due to acquired C1 esterase inhibitor deficiency masquerading as suspected peritonitis: A case report
J. Emerg. Med.
41
e99-e101
2011
Homo sapiens
Abe, K.; Endo, Y.; Nakazawa, N.; Kanno, K.; Okubo, M.; Hoshino, T.; Fujita, T.
Unique phenotypes of C1s deficiency and abnormality caused by two compound heterozygosities in a Japanese family
J. Immunol.
182
1681-1688
2009
Homo sapiens (P09871)
Birnbaum, J.; Klotz, E.; Spies, C.D.; Mueller, J.; Vargas Hein, O.; Feller, J.; Lehmann, C.
Impact of combined C1 esterase inhibitor/coagulation factor XIII or N-acetylcysteine/tirilazad mesylate administration on leucocyte adherence and cytokine release in experimental endotoxaemia
J. Int. Med. Res.
36
748-759
2008
Rattus norvegicus
Busby, W.H.; Yocum, S.A.; Rowland, M.; Kellner, D.; Lazerwith, S.; Sverdrup, F.; Yates, M.; Radabaugh, M.; Clemmons, D.R.
Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid
Osteoarthritis Cartilage
17
547-555
2009
Homo sapiens
Dagen, C.; Craig, T.J.
Treatment of hereditary angioedema: items that need to be addressed in practice parameters
Allergy Asthma Clin. Immunol.
6
11
2010
Homo sapiens
Craig, T.J.; Levy, R.J.; Wasserman, R.L.; Bewtra, A.K.; Hurewitz, D.; Obtulowicz, K.; Reshef, A.; Ritchie, B.; Moldovan, D.; Shirov, T.; Grivcheva-Panovska, V.; Kiessling, P.C.; Keinecke, H.O.; Bernstein, J.A.
Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks
J. Allergy Clin. Immunol.
124
801-808
2009
Homo sapiens
Grosskinsky, S.; Schott, M.; Brenner, C.; Cutler, S.J.; Simon, M.M.; Wallich, R.
Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis
PLoS Negl. Trop. Dis.
4
e698
2010
Homo sapiens
Rajabi, M.; Struble, E.; Zhou, Z.; Karnaukhova, E.
Potentiation of C1-esterase inhibitor by heparin and interactions with C1s protease as assessed by surface plasmon resonance
Biochim. Biophys. Acta
1820
56-63
2011
Homo sapiens, Homo sapiens (P09871)
Brier, S.; Pflieger, D.; Le Mignon, M.; Bally, I.; Gaboriaud, C.; Arlaud, G.J.; Daniel, R.
Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex
J. Biol. Chem.
285
32251-32263
2010
Homo sapiens
Subasinghe, N.L.; Khalil, E.; Travins, J.M.; Ali, F.; Ballentine, S.K.; Hufnagel, H.R.; Pan, W.; Leonard, K.; Bone, R.F.; Soll, R.M.; Crysler, C.S.; Ninan, N.; Kirkpatrick, J.; Kolpak, M.X.; Diloreto, K.A.; Eisennagel, S.H.; Huebert, N.D.; Molloy, C.J.; Tomczuk, B.E.; Gaul, M.D.
Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s
Bioorg. Med. Chem. Lett.
22
5303-5307
2012
Homo sapiens (P09871)
Shi, J.; Rose, E.L.; Singh, A.; Hussain, S.; Stagliano, N.E.; Parry, G.C.; Panicker, S.
TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins
Blood
123
4015-4022
2014
Homo sapiens (P09871), Homo sapiens
Wijeyewickrema, L.C.; Duncan, R.C.; Pike, R.N.
The role of the lys628 (192) residue of the complement protease, C1s, in interacting with peptide and protein substrates
Front. Immunol.
5
444
2014
Homo sapiens (P09871)
Carroll, S.; Georgiou, G.
Antibody-mediates inhibition of human C1s and the classical complement pathway
Immunobiology
218
1041-1048
2013
Homo sapiens (P09871), Homo sapiens
Wijeyewickrema, L.C.; Yongqing, T.; Tran, T.P.; Thompson, P.E.; Viljoen, J.E.; Coetzer, T.H.; Duncan, R.C.; Kass, I.; Buckle, A.M.; Pike, R.N.
Molecular determinants of the substrate specificity of the complement-initiating protease, C1r
J. Biol. Chem.
288
15571-15580
2013
Homo sapiens (P09871)
Venkatraman Girija, U.; Gingras, A.R.; Marshall, J.E.; Panchal, R.; Sheikh, M.A.; Gal, P.; Schwaeble, W.J.; Mitchell, D.A.; Moody, P.C.; Wallis, R.
Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation
Proc. Natl. Acad. Sci. USA
110
13916-13920
2013
Homo sapiens (P09871)
Bally, I.; Ancelet, S.; Moriscot, C.; Gonnet, F.; Mantovani, A.; Daniel, R.; Schoehn, G.; Arlaud, G.J.; Thielens, N.M.
Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites
Proc. Natl. Acad. Sci. USA
110
8650-8655
2013
Homo sapiens (P09871)
Beveridge, A.J.; Wallis, R.; Samani, N.J.
A molecular dynamics study of C1r and C1s dimers: implications for the structure of the C1 complex
Proteins
80
1987-1997
2012
Homo sapiens (P09871)
Skoog, S.M.; Wiseman, J.S.; Bey, P.
The specificity of two proteinases that cleave adjacent to argirnine, Cl esterase and acrosin, for pepfide p-nitroanilide substrates
Biochim. Biophys. Acta
996
89.94
1989
Homo sapiens (P09871), Homo sapiens
Kapferer-Seebacher, I.; Pepin, M.; Werner, R.; Aitman, T.J.; Nordgren, A.; Stoiber, H.; Thielens, N.; Gaboriaud, C.; Amberger, A.; Schossig, A.; Gruber, R.; Giunta, C.; Bamshad, M.; Bjoerck, E.; Chen, C.; Chitayat, D.; Dorschner, M.; Schmitt-Egenolf, M.; Hale, C.J.; Hanna, D.; Hennies, H.C.; Heiss-Kisielewsky, I.
Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement
Am. J. Hum. Genet.
99
1005-1014
2016
Homo sapiens (P09871)
Li, S.; Yu, B.; Byrne, G.; Wright, M.; ORourke, S.; Mesa, K.; Berman, P.W.
Identification and CRISPR/Cas9 knockout of the endogenous C1s protease in CHO cells eliminates aberrant proteolysis of recombinantly expressed proteins
Biotechnol. Bioeng.
116
2130-2145
2019
Homo sapiens
Jaeger, U.; DSa, S.; Schoergenhofer, C.; Bartko, J.; Derhaschnig, U.; Sillaber, C.; Jilma-Stohlawetz, P.; Fillitz, M.; Schenk, T.; Patou, G.; Panicker, S.; Parry, G.C.; Gilbert, J.C.; Jilma, B.
Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease a first-in-human trial
Blood
133
893-901
2019
Homo sapiens
Nilojan, J.; Bathige, S.D.N.K.; Kugapreethan, R.; Yang, H.; Kim, M.J.; Nam, B.H.; Lee, J.
Molecular features and the transcriptional and functional delineation of complement system activators C1r and C1s from Sebastes schlegelii
Dev. Comp. Immunol.
81
279-290
2018
Sebastes schlegelii (A0A2I6BQK3)
Godahewa, G.I.; Bathige, S.D.; Herath, H.M.; Noh, J.K.; Lee, J.
Characterization of rock bream (Oplegnathus fasciatus) complement components C1r and C1s in terms of molecular aspects, genomic modulation, and immune responsive transcriptional profiles following bacterial and viral pathogen exposure
Fish Shellfish Immunol.
46
656-668
2015
Oplegnathus fasciatus (A0A0K0LFC9)
Almitairi, J.O.M.; Venkatraman Girija, U.; Furze, C.M.; Simpson-Gray, X.; Badakshi, F.; Marshall, J.E.; Schwaeble, W.J.; Mitchell, D.A.; Moody, P.C.E.; Wallis, R.
Structure of the C1r-C1s interaction of the C1 complex of complement activation
Proc. Natl. Acad. Sci. USA
115
768-773
2018
Homo sapiens (P09871)
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