Reference on EC 3.4.21.22 - coagulation factor IXa
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fujikawa, K.; Legaz, M.E.; Kato, H.; Davie, E.W.
The mechanism of activation of bovine factor IX (Christmas factor) by bovine factor XIa (activated plasma thromboplastin antecedent)
Biochemistry
13
4508-4516
1974
Bos taurus
Thompson, A.R.
Structure, function and molecular defects of factor IX
Blood
67
565-572
1986
Homo sapiens
Van Dieijen, G.; Janssen-Claessen, T.
Purification of coagulation factors and preparation of reagents for chromogenic substrate assays
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
390-394
1986
Bos taurus
-
Osterud, B.; Bouma, B.N.; Griffin, J.H.
Human blood coagulation factor IX
J. Biol. Chem.
253
5946-5951
1978
Homo sapiens
Sturzebecher, J.; Kopetzki, E.; Bode, W.; Hopfner, K.P.
Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols
FEBS Lett.
412
295-300
1997
Homo sapiens
Morita, T.; Fukudome, K.; Miyata, T.; Iwanaga, S.
gamma-Carboxylglutamic acid (Gla)-domainless blood coagulation factor IXa species: preparation and properties
J. Biochem.
110
990-996
1991
Bos taurus
London, F.S.; Walsh, P.N.
Zymogen factor IX potentiates factor IXa-catalyzed activation
Biochemistry
39
9850-9858
2000
Homo sapiens
Hopfner, K.P.; Lang, A.; Karcher, A.; Sichler, K.; Kopetzki, E.; Barndstetter, H.; Huber, R.; Bode, W.; Engh, R.A.
Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding
Structure Fold. Des.
7
989-996
1999
Homo sapiens
Fay, P.J.; Koshibu, K.; Mastri, M.
The A1 and the A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity
J. Biol. Chem.
274
15401-15406
1999
Homo sapiens
Ahmed, S.S.; Rawala-Sheikh, R.; Monroe, D.M.; Roberts, H.R.; Walsh, P.N.
Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules
J. Biol. Chem.
265
20907-20911
1990
Homo sapiens
Blostein, M.D.; Rigby, A.C.; Furie, B.C.; Furie, B.; Gilbert, G.E.
Amphipathic helices support function of blood coagulation factor IXa
Biochemistry
39
12000-12006
2000
Homo sapiens
Falls, L.A.; Furie, B.; Furie, B.C.
Role of phosphatidylethanolamine in assembly and function of the factor IXa-factor VIIIa complex on membrane surfaces
Biochemistry
39
13216-13222
2000
Homo sapiens
Ahmad, S.S.; Walsh, P.N.
Coordinate binding studies of the substrate (factor X) with the cofactor (factor VIII) in the assembly of the factor X activating complex on the activated platelet surface
Biochemistry
41
11269-11276
2002
Homo sapiens
Bedsted, T.; Swanson, R.; Chuang, Y.J.; Bock, P.E.; Bjork, I.; Olson, S.T.
Heparin and calcium ions dramatically enhance antithrombin reactivity with factor IXa by generating new interaction exosites
Biochemistry
42
8143-8152
2003
Homo sapiens
Bajaj, S.P.; Schmidt, A.E.; Mathur, A.; Padmanabhan, K.; Zhong, D.; Mastri, M.; Fay, P.J.
Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa
J. Biol. Chem.
276
16302-16309
2001
Homo sapiens (P00740)
Wilkinson, F.H.; London, F.S.; Walsh, P.N.
Residues 88-109 of factor IXa are important for assembly of the factor X activating complex
J. Biol. Chem.
277
5725-5733
2002
Homo sapiens
Yang, L.; Manithody, C.; Olson, S.T.; Rezaie, A.R.
Contribution of basic residues of the autolysis loop to the substrate and inhibitor specificity of factor IXa
J. Biol. Chem.
278
25032-25038
2003
Homo sapiens (P00740)
Blostein, M.D.; Furie, B.C.; Rajotte, I.; Furie, B.
The Gla domain of factor IXa binds to factor VIIIa in the tenase complex
J. Biol. Chem.
278
31297-31302
2003
Homo sapiens
Wiebe, E.M.; Stafford, A.R.; Fredenburgh, J.C.; Weitz, J.I.
Mechanism of catalysis of inhibition of factor IXa by antithrombin in the presence of heparin or pentasaccharide
J. Biol. Chem.
278
35767-35774
2003
Homo sapiens
Rohlena, J.; Kolkman, J.A.; Boertjes, R.C.; Mertens, K.; Lenting, P.J.
Residues Phe342-Asn346 of activated coagulation factor IX contribute to the interaction with low density lipoprotein receptor-related protein
J. Biol. Chem.
278
9394-9401
2003
Homo sapiens
Rusconi, C.P.; Scardino, E.; Layzer, J.; Pitoc, G.A.; Ortel, T.L.; Monroe, D.; Sullenger, B.A.
RNA aptamers as reversible antagonists of coagulation factor IXa
Nature
419
90-94
2002
Homo sapiens
Panteleev, M.A.; Saenko, E.L.; Ananyeva, N.M.; Ataullakhanov, F.I.
Kinetics of Factor X activation by the membrane-bound complex of Factor IXa and Factor VIIIa
Biochem. J.
381
779-794
2004
Homo sapiens
Yang, X.; Walsh, P.N.
An ordered sequential mechanism for Factor IX and Factor IXa binding to platelet receptors in the assembly of the Factor X-activating complex
Biochem. J.
390
157-167
2005
Homo sapiens
Neuenschwander, P.F.
Exosite occupation by heparin enhances the reactivity of blood coagulation factor IXa
Biochemistry
43
2978-2986
2004
Homo sapiens
Batt, D.G.; Qiao, J.X.; Modi, D.P.; Houghton, G.C.; Pierson, D.A.; Rossi, K.A.; Luettgen, J.M.; Knabb, R.M.; Jadhav, P.K.; Wexler, R.R.
5-Amidinoindoles as dual inhibitors of coagulation factors IXa and Xa
Bioorg. Med. Chem. Lett.
14
5269-5273
2004
Homo sapiens
Qiao, J.X.; Cheng, X.; Modi, D.P.; Rossi, K.A.; Luettgen, J.M.; Knabb, R.M.; Jadhav, P.K.; Wexler, R.R.
5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa
Bioorg. Med. Chem. Lett.
15
29-35
2005
Homo sapiens
Lu, G.; Broze, G.J.; Krishnaswamy, S.
Formation of factors IXa and Xa by the extrinsic pathway: differential regulation by tissue factor pathway inhibitor and antithrombin III
J. Biol. Chem.
279
17241-17249
2004
Homo sapiens
Butenas, S.; Orfeo, T.; Gissel, M.T.; Brummel, K.E.; Mann, K.G.
The significance of circulating factor IXa in blood
J. Biol. Chem.
279
22875-22882
2004
Homo sapiens
Yang, X.; Chang, Y.J.; Lin, S.W.; Walsh, P.N.
Identification of residues Asn89, Ile90, and Val107 of the factor IXa second epidermal growth factor domain that are essential for the assembly of the factor X-activating complex on activated platelets
J. Biol. Chem.
279
46400-46405
2004
Homo sapiens (P00740)
Schmidt, A.E.; Stewart, J.E.; Mathur, A.; Krishnaswamy, S.; Bajaj, S.P.
Na+ site in blood coagulation factor IXa: effect on catalysis and factor VIIIa binding
J. Mol. Biol.
350
78-91
2005
Homo sapiens (P00740)
Ndonwi, M.; Broze, G.; Bajaj, S.P.
The first epidermal growth factor-like domains of factor Xa and factor IXa are important for the activation of the factor VII-tissue factor complex
J. Thromb. Haemost.
3
112-118
2005
Homo sapiens
London, F.S.; Marcinkiewicz, M.; Walsh, P.N.
PAR-1-stimulated factor IXa binding to a small platelet subpopulation requires a pronounced and sustained increase of cytoplasmic calcium
Biochemistry
45
7289-7298
2006
Homo sapiens
Misenheimer, T.M.; Buyue, Y.; Sheehan, J.P.
The heparin-binding exosite is critical to allosteric activation of factor IXa in the intrinsic tenase complex: the role of arginine 165 and factor X
Biochemistry
46
7886-7895
2007
Homo sapiens
Neuenschwander, P.F.; Williamson, S.R.; Nalian, A.; Baker-Deadmond, K.J.
Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains
J. Biol. Chem.
281
23066-23074
2006
Homo sapiens (P00740)
Gale, A.J.; Radtke, K.P.; Cunningham, M.A.; Chamberlain, D.; Pellequer, J.L.; Griffin, J.H.
Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants
J. Thromb. Haemost.
4
1315-1322
2006
Homo sapiens
Scheiflinger, F.; Dockal, M.; Rosing, J.; Kerschbaumer, R.J.
Enhancement of the enzymatic activity of activated coagulation factor IX by anti-factor IX antibodies
J. Thromb. Haemost.
6
315-322
2008
Homo sapiens
Yang, L.; Gopalakrishna, K.; Manithody, C.; Rezaie, A.R.
Expression, purification and characterization of factor IX derivatives using a novel vector system
Protein Expr. Purif.
50
196-202
2006
Homo sapiens (P00740)
Gopalakrishna, K.; Rezaie, A.R.
The influence of sodium ion binding on factor IXa activity
Thromb. Haemost.
95
936-941
2006
Homo sapiens
Zoegg, T.; Brandstetter, H.
Activation mechanisms of coagulation factor IX
Biol. Chem.
390
391-400
2009
Homo sapiens
Yang, Y.H.; Chien, D.; Wu, M.; FitzGerald, J.; Grossman, J.M.; Hahn, B.H.; Hwang, K.K.; Chen, P.P.
Novel autoantibodies against the activated coagulation factor IX (FIXa) in the antiphospholipid syndrome that interpose the FIXa regulation by antithrombin
J. Immunol.
182
1674-1680
2009
Homo sapiens
Becker, R.C.; Oney, S.; Becker, K.C.; Sullenger, B.
Antidote-controlled antithrombotic therapy targeting factor IXa and von Willebrand factor
Ann. N. Y. Acad. Sci.
1175
61-70
2009
Homo sapiens
Gettins, P.G.; Olson, S.T.
Activation of antithrombin as a factor IXa and Xa inhibitor involves mitigation of repression rather than positive enhancement
FEBS Lett.
583
3397-3400
2009
Homo sapiens
Kim, W.H.; Kim, J.S.; Kim, J.S.; Yoon, Y.; Lee, G.M.
Effect of Ca2+ and Mg2+ concentration in culture medium on the activation of recombinant factor IX produced in Chinese hamster ovary cells
J. Biotechnol.
142
275-278
2009
Homo sapiens
Hartmann, R.; Dockal, M.; Kammlander, W.; Panholzer, E.; Nicolaes, G.A.; Fiedler, C.; Rosing, J.; Scheiflinger, F.
Factor IX mutants with enhanced catalytic activity
J. Thromb. Haemost.
7
1656-1662
2009
Homo sapiens
Zgg, T.; Brandstetter, H.
Structural basis of the cofactor- and substrate-assisted activation of human coagulation factor IXa
Structure
17
1669-1678
2009
Homo sapiens (P00740), Homo sapiens
Hosseini, S.; Zomorodipour, A.; Jalal, R.; Sabouni, F.; Ataei, F.
A study of the expression of functional human coagulation factor IX in keratinocytes using a nonviral vector regulated by K14 promoter
Appl. Biochem. Biotechnol.
162
1599-1611
2010
Homo sapiens
Misenheimer, T.M.; Sheehan, J.P.
The regulation of factor IXa by supersulfated low molecular weight heparin
Biochemistry
49
9997-10005
2010
Homo sapiens
Yang, L.; Manithody, C.; Qureshi, S.H.; Rezaie, A.R.
Role of the residues of the 39-loop in determining the substrate and inhibitor specificity of factor IXa
J. Biol. Chem.
285
28488-28495
2010
Homo sapiens
Wang, S.; Beck, R.; Blench, T.; Burd, A.; Buxton, S.; Malic, M.; Ayele, T.; Shaikh, S.; Chahwala, S.; Chander, C.; Holland, R.; Merette, S.; Zhao, L.; Blackney, M.; Watts, A.
Studies of benzothiophene template as potent factor IXa (FIXa) inhibitors in thrombosis
J. Med. Chem.
53
1465-1472
2010
Homo sapiens
Wang, S.; Beck, R.; Burd, A.; Blench, T.; Marlin, F.; Ayele, T.; Buxton, S.; Dagostin, C.; Malic, M.; Joshi, R.; Barry, J.; Sajad, M.; Cheung, C.; Shaikh, S.; Chahwala, S.; Chander, C.; Baumgartner, C.; Holthoff, H.P.; Murray, E.; Blackney, M.; Giddings, A.
Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors
J. Med. Chem.
53
1473-1482
2010
Homo sapiens
Chang, L.; Yang, C.; Chua, A.; Lin, Y.; Lai, S.
Sustained release of transgenic human factor IX: Preparation, characterization, and in vivo efficacy
Mol. Pharm.
8
1767-1774
2011
Homo sapiens
Johnson, D.J.; Langdown, J.; Huntington, J.A.
Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex
Proc. Natl. Acad. Sci. USA
107
645-650
2010
Homo sapiens (P00740)
Wu, H.; Xu, X.; Zhang, L.; Shen, D.; Peng, L.; Zhang, Y.; Song, J.
Mg(II)-induced binding of factor IX-binding protein from the venom of Agkistrodon Halys Pallas with factor Xa
Toxicon
55
1358-1364
2010
Homo sapiens
Cunha, N.; Murad, A.; Ramos, G.; Maranhao, A.; Brgido, M.; Araujo, A.; Lacorte, C.; Aragao, F.; Covas, D.; Fontes, A.; Souza, G.; Vianna, G.; Rech, E.
Accumulation of functional recombinant human coagulation factor IX in transgenic soybean seeds
Transgenic Res.
20
841-855
2011
Homo sapiens (P00740), Homo sapiens
Venkateswarlu, D.
Structural insights into the interaction of blood coagulation co-factor VIIIa with factor IXa: a computational protein-protein docking and molecular dynamics refinement study
Biochem. Biophys. Res. Commun.
452
408-414
2014
Homo sapiens
Branchini, A.; Campioni, M.; Mazzucconi, M.; Biondo, F.; Mari, R.; Bicocchi, M.; Bernardi, F.; Pinotti, M.
Replacement of the Y450 (c234) phenyl ring in the carboxyl-terminal region of coagulation factor IX causes pleiotropic effects on secretion and enzyme activity
FEBS Lett.
587
3249-3253
2013
Homo sapiens
Sullenger, B.; Woodruff, R.; Monroe, D.M.
Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction
J. Biol. Chem.
287
12779-12786
2012
Homo sapiens
Geng, Y.; Verhamme, I.M.; Messer, A.; Sun, M.F.; Smith, S.B.; Bajaj, S.P.; Gailani, D.
A sequential mechanism for exosite-mediated factor IX activation by factor XIa
J. Biol. Chem.
287
38200-38209
2012
Homo sapiens
Yang, L.; Rezaie, A.R.
Residues of the 39-loop restrict the plasma inhibitor specificity of factor IXa
J. Biol. Chem.
288
12692-12698
2013
Bos taurus, Mus musculus
Bloem, E.; Meems, H.; van den Biggelaar, M.; Mertens, K.; Meijer, A.B.
A3 domain region 1803-1818 contributes to the stability of activated factor VIII and includes a binding site for activated factor IX
J. Biol. Chem.
288
26105-26111
2013
Homo sapiens
Wakabayashi, H.; Fay, P.J.
Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa
J. Biol. Chem.
288
31289-31297
2013
Homo sapiens
Neuenschwander, P.F.; Deadmond, K.J.; Zepeda, K.; Rutland, J.
Correlation of factor IXa subsite modulations with effects on substrate discrimination
J. Thromb. Haemost.
10
382-389
2012
Homo sapiens
Majumder, R.; Koklic, T.; Sengupta, T.; Cole, D.; Chattopadhyay, R.; Biswas, S.; Monroe, D.; Lentz, B.R.
Soluble phosphatidylserine binds to two sites on human factor IXa in a Ca2+ dependent fashion to specifically regulate structure and activity
PLoS ONE
9
e100006
2014
Homo sapiens
Kristensen, L.H.; Olsen, O.H.; Blouse, G.E.; Brandstetter, H.
Releasing the brakes in coagulation factor IXa by co-operative maturation of the substrate-binding site
Biochem. J.
473
2395-2411
2016
Homo sapiens (P00740)
Meng, D.; Andre, P.; Bateman, T.J.; Berger, R.; Chen, Y.H.; Desai, K.; Dewnani, S.; Ellsworth, K.; Feng, D.; Geissler, W.M.; Guo, L.; Hruza, A.; Jian, T.; Li, H.; Metzger, J.; Parker, D.L.; Reichert, P.; Sherer, E.C.; Smith, C.J.; Sonatore, L.M.; Tschirret-Guth, R.; Wu, J.; Xu, J.; Zhang, T.; Campeau, L.C.; Orr,
Development of a novel tricyclic class of potent and selective FIXa inhibitors
Bioorg. Med. Chem. Lett.
25
5437-5443
2015
Homo sapiens
Sakurada, I.; Endo, T.; Hikita, K.; Hirabayashi, T.; Hosaka, Y.; Kato, Y.; Maeda, Y.; Matsumoto, S.; Mizuno, T.; Nagasue, H.; Nishimura, T.; Shimada, S.; Shinozaki, M.; Taguchi, K.; Takeuchi, K.; Yokoyama, T.; Hruza, A.; Reichert, P.; Zhang, T.; Wood, H.B.; Nakao, K.; Furusako, S.
Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors
Bioorg. Med. Chem. Lett.
27
2622-2628
2017
Homo sapiens (P00740)
Kitazawa, T.; Shima, M.
Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity
Int. J. Hematol.
111
20-30
2018
Homo sapiens
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