Disease on EC 3.4.21.20 - cathepsin G
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Abscess
Histochemical localization of neutral proteases released during development of rat periradicular lesion.
Acromegaly
Human nasal septal cartilage: analysis of intracellular enzyme activities, glycogen content, cell density and clonal proliferation of septal chondrocytes of healthy adults and acromegalic patients.
Acromegaly
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acute Lung Injury
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G.
Acute Lung Injury
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Adenocarcinoma
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Aggressive Periodontitis
Neutrophil lysosomal nonoxidative microbicidal proteins in early-onset periodontitis.
Albuminuria
Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase.
Albuminuria
Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Albuminuria
Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice.
Alzheimer Disease
Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein.
Alzheimer Disease
Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease.
Alzheimer Disease
Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease.
Anaphylaxis
Postmortem detection of antibiotic-specific immunoglobulin E in the case of anaphylactic death.
Anti-Glomerular Basement Membrane Disease
The isolation of a neutral proteinase from the urine of a patient with Goodpasture's Syndrome.
Aortic Aneurysm, Abdominal
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
Arthritis
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Arthritis
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis
Human mononuclear cells and neutral proteinases. III. Neutral proteinases and rheumatoid arthritis: monocytes as a source of cathepsin G and proteinase potentiation of IgM rheumatoid factor elaboration.
Arthritis
Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.
Arthritis
Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator.
Arthritis, Experimental
Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis.
Arthritis, Juvenile
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Arthritis, Rheumatoid
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Arthritis, Rheumatoid
Cathepsin G: the significance in rheumatoid arthritis as a monocyte chemoattractant.
Arthritis, Rheumatoid
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis, Rheumatoid
Human leucocyte elastase and cathepsin G: structural and functional characteristics.
Arthritis, Rheumatoid
Human mononuclear cells and neutral proteinases. III. Neutral proteinases and rheumatoid arthritis: monocytes as a source of cathepsin G and proteinase potentiation of IgM rheumatoid factor elaboration.
Arthritis, Rheumatoid
Neutrophil elastase and cathepsin G: structure, function, and biological control.
Arthritis, Rheumatoid
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Arthritis, Rheumatoid
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Arthritis, Rheumatoid
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Arthritis, Rheumatoid
The inhibitory effects of antirheumatic drugs on the activity of human leukocyte elastase and cathepsin G.
Asthma
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Asthma
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Asthma
Systemic upregulation of neutrophil {alpha}-defensins and serine proteases in neutrophilic asthma.
Atherosclerosis
Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.
Atherosclerosis
Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding.
Bone Resorption
Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study.
Bone Resorption
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.
Brain Injuries
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Brain Ischemia
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Breast Neoplasms
Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
Breast Neoplasms
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Breast Neoplasms
Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation.
Breast Neoplasms
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.
Breast Neoplasms
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1.
Breast Neoplasms
Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase.
Breast Neoplasms
Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.
Breast Neoplasms
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Bronchiectasis
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
Bronchiectasis
Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis.
Bronchopulmonary Dysplasia
SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.
Carcinogenesis
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Carcinoma
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
Carcinoma
Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.
Carcinoma
Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum.
Carcinoma
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Carcinoma
Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells.
Carcinoma
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Carcinoma
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Carcinoma
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features.
Carcinoma
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Carcinoma, Ehrlich Tumor
Purification and further characterization of the Ca2+-activated proteinase specific for the intermediate filament proteins vimentin and desmin.
Carcinoma, Hepatocellular
High-molecular-weight neutral proteinase of rat ascites hepatoma cells and their collagenolytic activity.
Carcinoma, Hepatocellular
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Carcinoma, Lewis Lung
Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells.
Carcinoma, Lewis Lung
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Carcinoma, Renal Cell
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Carcinoma, Squamous Cell
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Carcinoma, Squamous Cell
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Carcinoma, Squamous Cell
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features.
cathepsin g deficiency
Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.
cathepsin g deficiency
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
cathepsin g deficiency
Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.
Cerebrovascular Disorders
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Chediak-Higashi Syndrome
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
Chediak-Higashi Syndrome
Neutrophil elastase and cathepsin G protein and messenger RNA expression in bone marrow from a patient with Chediak-Higashi syndrome.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Chronic Periodontitis
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Chronic Periodontitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Chronic Periodontitis
Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.
Chronic Periodontitis
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Colitis
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Anti-cathepsin G antibodies in the sera of patients with ulcerative colitis.
Colitis, Ulcerative
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Colitis, Ulcerative
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Colitis, Ulcerative
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Colitis, Ulcerative
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis.
Colitis, Ulcerative
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2.
Crohn Disease
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Crohn Disease
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Crohn Disease
Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents.
Cystic Fibrosis
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Cystic Fibrosis
Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors.
Cystic Fibrosis
Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.
Cystic Fibrosis
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Cystic Fibrosis
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Dementia
Increased elastase and cathepsin G activity in activated lymphocytes from aged patients Role of denutrition and dementia.
Demyelinating Diseases
Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study.
Dermatitis, Atopic
Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy.
Diabetes Mellitus, Type 1
Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes.
Diabetes Mellitus, Type 1
Regulation of cathepsin g reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.
Encephalomyelitis, Autoimmune, Experimental
Changes in cathepsins B-1 and D, neutral proteinase and 2',3'-cyclic nucleotide-3'-phosphohydrolase activities in monkey brain with experimental allergic encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Treatment of an encephalitogenic peptide from guinea pig myelin basic protein with alpha-protease and thermolysin. Isolation of fragments and determination of cleavage sites.
Endometriosis
Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor.
Endotoxemia
Alternative pathways for angiotensin II production as an important determinant of kidney damage in endotoxemia.
Epstein-Barr Virus Infections
A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection.
Favism
Oxidative inactivation of the calcium-stimulated neutral proteinase from human red blood cells by divicine and intracellular protection by reduced glutathione.
Gingivitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Gingivitis
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Gingivitis
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study.
Gingivitis
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Glioblastoma
Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells.
Glioma
Hydrogen Peroxide-Induced Oxidative Stress Activates Proteasomal Trypsin-Like Activity in Human U373 Glioma Cells.
Glomerulonephritis
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Glomerulonephritis
Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.
Granuloma
Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse.
Granuloma
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice.
Heart Failure
Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart.
Hemangioendothelioma
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Hepatitis C, Chronic
Prevalence of ANCA in mixed cryoglobulinemia and chronic hepatitis C virus infection.
HIV Infections
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
HIV Infections
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.
HIV Infections
Thrombin activates envelope glycoproteins of HIV type 1 and enhances fusion.
Hyperalgesia
Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study.
Hyperhomocysteinemia
Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats.
Hypersensitivity
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice.
Hypertension
Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease.
Infections
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Infections
Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.
Infections
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Infections
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
Infections
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Infections
Elastase and cathepsin G activities are present in immature bone marrow neutrophils and absent in late marrow and circulating neutrophils of beige (Chediak-Higashi) mice.
Infections
Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase.
Infections
Inhibition of U-937 membrane-associated cathepsin G by GP120 (IIIB) and V3 loop-derived peptides from several strains of HIV-1.
Infections
Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein.
Infections
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Infections
Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice.
Infections
Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.
Infections
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
Infections
Nonchromogenic hydrolysis of elastase and cathepsin G p-nitroanilide substrates by Pseudomonas aeruginosa elastase.
Infections
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Infections
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Infections
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.
Infections
The effects of Fasciola hepatica infection on the total antioxidant status (TAS) and the activity of proteases and their inhibitors in rat serum.
Infections
The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.
Infections
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study.
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Influenza, Human
Critical Role of SerpinB1 in Regulating Inflammatory Responses in Pulmonary Influenza Infection.
Ischemic Stroke
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Joint Diseases
Influence of some natural and semisynthetic agents on elastase and cathepsin G from polymorphonuclear granulocytes.
Keloid
Expression of Cathepsins B, D, and G by the Embryonic Stem Cell-Like Population within Human Keloid Tissues and Keloid-Derived Primary Cell Lines.
Keratoconus
Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas.
Leukemia
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Leukemia
All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia.
Leukemia
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
Leukemia
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Leukemia
Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.
Leukemia
Corynebacterium parvum, but not BCG, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice.
Leukemia
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Leukemia
Immunocytochemical identification of abnormal polymorphonuclear neutrophils in patients with leukemia.
Leukemia
Plasma levels of human granulocytic elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in leukemia.
Leukemia
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Leukemia
The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
Leukemia
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Leukemia, Erythroblastic, Acute
Murine erythroleukemia cell differentiation: possible involvement of a calcium dependent neutral proteinase.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Myeloid
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.
Leukemia, Myeloid
Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G.
Leukemia, Myeloid, Acute
A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia.
Leukemia, Myeloid, Acute
AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia.
Leukemia, Myeloid, Acute
Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.
Leukemia, Myeloid, Acute
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Leukemia, Myeloid, Acute
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Leukemia, Promyelocytic, Acute
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Leukemia, Promyelocytic, Acute
The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
Lung Diseases
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Lung Diseases
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Lung Diseases
Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases.
Lung Diseases
Separation of closely related peptide substrates of human proteinases by micellar electrokinetic chromatography with anionic and nonionic surfactants.
Lung Injury
Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice.
Lung Injury
Suppression of superantigen-induced lung injury and vasculitis by preadministration of human urinary trypsin inhibitor.
Lung Neoplasms
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Lung Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Lung Neoplasms
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Lupus Erythematosus, Systemic
Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Antibodies to human myeloperoxidase in glomerular immune deposits of systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Defensins- and cathepsin G-ANCA in systemic lupus erythematosus.
Lupus Nephritis
Antineutrophil cytoplasmic autoantibodies (ANCA) and their target antigens in Chinese patients with lupus nephritis.
Lymphatic Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Malaria
Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against cathepsin G.
Malnutrition
Effect of protein energy malnutrition on neutral proteinase in developing rat brain.
Mastocytoma
Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases.
Melanoma
Corynebacterium parvum, but not BCG, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice.
Melanoma
Evidence that the elevated levels of proteinase activity in the plasma of melanoma-bearing mice may be of host origin.
Melanoma, Experimental
Differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following Corynebacterium parvum treatment. Evidence for the involvement of polymorphonuclear leukocyte proteinases.
Multiple Sclerosis
A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection.
Multiple Sclerosis
Baisc protein hydrolysis in lymphocytes of Lewis rats with experimental allergic encephalomyelitis.
Multiple Sclerosis
Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study.
Multiple Sclerosis
Lysosomal hydrolases in cerebrospinal fluid of multiple sclerosis patients. A follow-up study.
Mycoses
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.
Myocardial Ischemia
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Neoplasm Metastasis
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Neoplasm Metastasis
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Neoplasm Metastasis
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Neoplasm Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Neoplasms
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
Neoplasms
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Neoplasms
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Neoplasms
Cathepsin G and alpha 1-antichymotrypsin in the local host reaction to loosening of total hip prostheses.
Neoplasms
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Neoplasms
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.
Neoplasms
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.
Neoplasms
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.
Neoplasms
Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1.
Neoplasms
Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.
Neoplasms
Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells.
Neoplasms
Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.
Neoplasms
Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area.
Neoplasms
Dissection of laminin by cathepsin G into its long-arm and short-arm structures and localization of regions involved in calcium dependent stabilization and self-association.
Neoplasms
Expression and Localization of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma.
Neoplasms
Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration.
Neoplasms
Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor alpha: modulation of these cellular responses by interleukin-6 and platelet-derived growth factor.
Neoplasms
Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum.
Neoplasms
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Neoplasms
Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.
Neoplasms
Processing of human cathepsin G after transfection to the rat basophilic/mast cell tumor line RBL.
Neoplasms
Purification and further characterization of the Ca2+-activated proteinase specific for the intermediate filament proteins vimentin and desmin.
Neoplasms
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Neoplasms
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Neoplasms
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Neoplasms
Tumor necrosis factor-alpha enhances platelet activation via cathepsin G released from neutrophils.
Neoplasms
Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase.
Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Neoplasms
Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression.
Nephritis
Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Neuroinflammatory Diseases
The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease.
Osteoarthritis
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Osteoarthritis
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Osteoarthritis
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Osteolysis
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Osteolysis
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.
Osteomyelitis
The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.
Pancreatitis
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
Pancreatitis
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Pancreatitis
Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-reflow in ischemia/reperfusion-induced acute pancreatitis.
Pancreatitis
Release of dog polymorphonuclear leukocyte cathepsin G, normally and in endotoxin and pancreatitic shock. Isolation and partial characterization of dog polymorphonuclear leukocyte cathepsin G.
Periodontal Diseases
Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells.
Periodontal Diseases
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease.
Periodontal Diseases
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Periodontal Pocket
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Periodontitis
Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis.
Periodontitis
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Periodontitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Periodontitis
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Periodontitis
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study.
Periodontitis
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Peritonitis
Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pneumonia
Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry.
Pneumonia
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation.
Pneumonia
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Pneumonia
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Pneumonia
Inflammatory response to particles in the rat lung: secretion of acid and neutral proteinases by bronchoalveolar leucocytes.
Pneumonia
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
Pneumonia
Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.
Pneumonia, Pneumocystis
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Prostatic Neoplasms
Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models.
Protein-Energy Malnutrition
Effect of protein energy malnutrition on neutral proteinase in developing rat brain.
Proteinuria
Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.
Proteinuria
The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo.
Psoriasis
Cathepsin G cleaves and activates IL-36? and promotes the inflammation of psoriasis.
Psoriasis
Downregulation of interleukin 36? and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris.
Psoriasis
Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs.
Psoriasis
Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation to disease activity.
Psoriasis
The activity of polymorphonuclear leukocyte neutral proteinases and their inhibitors in patients with psoriasis treated with a continuous peritoneal dialysis.
Pulmonary Disease, Chronic Obstructive
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Pulmonary Disease, Chronic Obstructive
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation.
Pulmonary Disease, Chronic Obstructive
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Pulmonary Disease, Chronic Obstructive
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Pulmonary Disease, Chronic Obstructive
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease.
Pulmonary Edema
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Pulmonary Emphysema
Leukoproteinases and pulmonary emphysema: cathepsin G and other chymotrypsin-like proteinases enhance the elastolytic activity of elastase on lung elastin.
Pulmonary Emphysema
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Purpura
[Activities of proteinases in invertebrate animals--potential objects of fish nutrition. Effects of temperature, pH, and heavy metals]
Renal Insufficiency, Chronic
Elastase and cathepsin G from primed leukocytes cleave vascular endothelial cadherin in hemodialysis patients.
Reperfusion Injury
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Respiratory Distress Syndrome
Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G.
Respiratory Distress Syndrome
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Sarcoma, Avian
Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin.
Sarcoma, Yoshida
Cartilage-degrading neutral proteinase secreted by Yoshida sarcoma cells. Purification and properties.
Scleroderma, Diffuse
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Scleroderma, Limited
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Scleroderma, Systemic
Autoantibodies to bactericidal/permeability-increasing protein and cathepsin G in systemic sclerosis.
Scleroderma, Systemic
Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis.
Scleroderma, Systemic
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Sepsis
Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis.
Sepsis
Human leukocyte elastase and cathepsin G inactivate factor VII by limited proteolysis.
Sepsis
Identification of a 14kDa endocan fragment generated by cathepsin G, a novel circulating biomarker in patients with sepsis.
Sepsis
Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.
Sepsis
Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects.
Shock, Septic
Therapeutic effects of the combination of two proteinase inhibitors in endotoxin shock of the pig.
Silicosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Silicosis
[Comparative analysis of serum proteomic profiles between patients with silicosis and chronic bronchitis].
Skin Diseases
Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
Small Cell Lung Carcinoma
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Squamous Cell Carcinoma of Head and Neck
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
ST Elevation Myocardial Infarction
Low-grade endotoxaemia enhances artery thrombus growth via Toll-like receptor 4: implication for myocardial infarction.
Subarachnoid Hemorrhage
Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage.
Thrombosis
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Thrombosis
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Thrombosis
Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents.
Thrombosis
Neutrophil cathepsin G modulates platelet P-selectin expression and inhibits P-selectin-mediated platelet-neutrophil adhesion.
Thrombosis
Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex.
Thrombosis
Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions.
Thrombosis
Protease-activated receptor 4: a critical participator in inflammatory response.
Thrombosis
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Tuberculosis
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Tuberculosis
Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages.
Tuberculosis
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.
Tuberculosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Urticaria
Heterozygous alpha 1-antichymotrypsin deficiency may be associated with cold urticaria.
Urticaria Pigmentosa
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.
Uterine Cervical Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Vascular System Injuries
Cathepsin G activates protease-activated receptor-4 in human platelets.
Vascular System Injuries
Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions.
Vasculitis
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Vasculitis
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Venous Thrombosis
Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G.
Vitamin A Deficiency
Neutrophil cathepsin G is specifically decreased under vitamin A deficiency.
Whooping Cough
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
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