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Disease on EC 3.4.21.20 - cathepsin G

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DISEASE
TITLE OF PUBLICATION
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Abscess
Histochemical localization of neutral proteases released during development of rat periradicular lesion.
Acromegaly
Human nasal septal cartilage: analysis of intracellular enzyme activities, glycogen content, cell density and clonal proliferation of septal chondrocytes of healthy adults and acromegalic patients.
Human nasal septal cartilage: local distribution of different enzyme activities in healthy adults and acromegalic patients.
Acute Lung Injury
IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G.
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Adenocarcinoma
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Aggressive Periodontitis
Neutrophil lysosomal nonoxidative microbicidal proteins in early-onset periodontitis.
Albuminuria
Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase.
Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Lack of albuminuria in the early heterologous phase of anti-GBM nephritis in beige mice.
Alzheimer Disease
Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein.
Enzymatic generation of the amino terminus of the beta-amyloid peptide.
Genetic polymorphism in the cathepsin G gene and the risk of Alzheimer's disease.
Mutation of the gene for the human lysosomal serine protease cathepsin G is not the cause of aberrant APP processing in familial Alzheimer disease.
Amyloidosis
Neutrophil proteases associated with amyloid fibrils.
Anaphylaxis
Postmortem detection of antibiotic-specific immunoglobulin E in the case of anaphylactic death.
Anti-Glomerular Basement Membrane Disease
The isolation of a neutral proteinase from the urine of a patient with Goodpasture's Syndrome.
Aortic Aneurysm
Activities of proteases in parietal thrombus of aortic aneurysm.
Aortic Aneurysm, Abdominal
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
Arthritis
Antigen induced arthritis in beige (Chediak-Higashi) mice.
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Human mononuclear cells and neutral proteinases. III. Neutral proteinases and rheumatoid arthritis: monocytes as a source of cathepsin G and proteinase potentiation of IgM rheumatoid factor elaboration.
Pathogenesis of antigen-induced arthritis in mice deficient in neutrophil elastase and cathepsin G.
Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator.
Arthritis, Experimental
Levels of collagenolytic activity, beta-glucuronidase, and collagen prolyl hydroxylase in paws from rats with developing adjuvant arthritis.
Arthritis, Juvenile
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Arthritis, Rheumatoid
Antineutrophil cytoplasmic antibodies against myeloperoxidase, proteinase 3, elastase, cathepsin G and lactoferrin in Japanese patients with rheumatoid arthritis.
Antineutrophil cytoplasmic antibodies in Bulgarian patients with rheumatoid arthritis: characterization and clinical associations.
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Cathepsin G: the significance in rheumatoid arthritis as a monocyte chemoattractant.
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes.
Human leucocyte elastase and cathepsin G: structural and functional characteristics.
Human mononuclear cells and neutral proteinases. III. Neutral proteinases and rheumatoid arthritis: monocytes as a source of cathepsin G and proteinase potentiation of IgM rheumatoid factor elaboration.
Neutrophil elastase and cathepsin G: structure, function, and biological control.
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
The inhibitory effects of antirheumatic drugs on the activity of human leukocyte elastase and cathepsin G.
Asthma
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Systemic upregulation of neutrophil {alpha}-defensins and serine proteases in neutrophilic asthma.
Atherosclerosis
Cathepsin G activity lowers plasma LDL and reduces atherosclerosis.
Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.
Human mast cell neutral proteases generate modified LDL particles with increased proteoglycan binding.
Autoimmune Diseases
Cathepsin G and Its Role in Inflammation and Autoimmune Diseases.
Bone Resorption
Bone health nutraceuticals alter microarray mRNA gene expression: A randomized, parallel, open-label clinical study.
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.
Brain Injuries
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Brain Ischemia
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
Breast Neoplasms
Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models.
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Cathepsin G Induces Cell Aggregation of Human Breast Cancer MCF-7 Cells via a 2-Step Mechanism: Catalytic Site-Independent Binding to the Cell Surface and Enzymatic Activity-Dependent Induction of the Cell Aggregation.
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.
Cathepsin G-Induced Insulin-Like Growth Factor (IGF) Elevation in MCF-7 Medium Is Caused by Proteolysis of IGF Binding Protein (IGFBP)-2 but Not of IGF-1.
Induction of multicellular 3-D spheroids of MCF-7 breast carcinoma cells by neutrophil-derived cathepsin G and elastase.
Insulin-like growth factor-1 signaling is responsible for cathepsin G-induced aggregation of breast cancer MCF-7 cells.
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Role of promyelocytic leukemia (PML) protein in tumor suppression.
Bronchiectasis
Potentiative effects of neutral proteinases in an inflamed lung: relationship of neutrophil procollagenase (proMMP-8) to plasmin, cathepsin G and tryptase in bronchiectasis in vivo.
Presence, activities, and molecular forms of cathepsin G, elastase, alpha 1-antitrypsin, and alpha 1-antichymotrypsin in bronchiectasis.
Bronchopulmonary Dysplasia
SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia.
Carcinogenesis
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Carcinoma
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.
Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum.
Neutrophil cathepsin G, but not elastase, induces aggregation of MCF-7 mammary carcinoma cells by a protease activity-dependent cell-oriented mechanism.
Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells.
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features.
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Carcinoma, Ehrlich Tumor
Purification and further characterization of the Ca2+-activated proteinase specific for the intermediate filament proteins vimentin and desmin.
Carcinoma, Hepatocellular
High-molecular-weight neutral proteinase of rat ascites hepatoma cells and their collagenolytic activity.
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Carcinoma, Lewis Lung
Proteoglycan- and fibrin-degrading neutral proteinase activities of Lewis lung carcinoma cells.
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Carcinoma, Renal Cell
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Carcinoma, Squamous Cell
Squamous cell carcinoma antigen 2 is a novel serpin that inhibits the chymotrypsin-like proteinases cathepsin G and mast cell chymase.
Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids.
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features.
cathepsin g deficiency
Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.
Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice.
Neutrophil influx into the lungs of beige mice is followed by elastolytic damage and emphysema.
Central Nervous System Infections
Proteolytic activity in CSF.
Cerebrovascular Disorders
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Chediak-Higashi Syndrome
Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.
Neutrophil elastase and cathepsin G protein and messenger RNA expression in bone marrow from a patient with Chediak-Higashi syndrome.
Cholangitis, Sclerosing
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Cholera
Effect of cell shape on proteinase secretion by epithelial cells.
Chronic Periodontitis
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Intracellular localization of Treponema denticola chymotrypsin-like proteinase in chronic periodontitis.
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Colitis
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4.
Colitis, Ulcerative
Anti-cathepsin G antibodies in the sera of patients with ulcerative colitis.
Antibodies to cathepsin G in Crohn's disease.
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: Role of cathepsin G and protease-activated receptor-4.
Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice: role of cathepsin G and protease-activated receptor-4.
Luminal cathepsin g and protease-activated receptor 4: a duet involved in alterations of the colonic epithelial barrier in ulcerative colitis.
Neutrophil cytoplasmic antibodies (p-ANCA) in ulcerative colitis.
Novel autoantigens of perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) in ulcerative colitis: non-histone chromosomal proteins, HMG1 and HMG2.
p-ANCA target antigens in ulcerative colitis.
Crohn Disease
Antibodies to cathepsin G in Crohn's disease.
Antigen specificity of circulating anti-neutrophil cytoplasmic antibodies in inflammatory bowel disease.
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Neutrophil and eosinophil involvement of the small bowel in patients with celiac disease and Crohn's disease: studies on the secretion rate and immunohistochemical localization of granulocyte granule constituents.
Cutis Laxa
Elastin production and degradation in cutis laxa acquisita.
Cystic Fibrosis
Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis.
Cystic fibrosis sputum induces a secretory response from airway gland serous cells that can be prevented by neutrophil protease inhibitors.
Effect of DNase on the activity of neutrophil elastase, cathepsin G and proteinase 3 in the presence of DNA.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Dementia
Increased elastase and cathepsin G activity in activated lymphocytes from aged patients Role of denutrition and dementia.
Demyelinating Diseases
Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study.
Dental Plaque
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Cellular source, activation and inhibition of dental plaque collagenase.
Dermatitis, Atopic
Modulation of cathepsin G expression in severe atopic dermatitis following medium-dose UVA1 phototherapy.
Dermatomyositis
The role and mechanism of cathepsin G in dermatomyositis.
Diabetes Mellitus, Type 1
Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes.
Regulation of cathepsin g reduces the activation of proinsulin-reactive T cells from type 1 diabetes patients.
Encephalomyelitis, Autoimmune, Experimental
Changes in cathepsins B-1 and D, neutral proteinase and 2',3'-cyclic nucleotide-3'-phosphohydrolase activities in monkey brain with experimental allergic encephalomyelitis.
Treatment of an encephalitogenic peptide from guinea pig myelin basic protein with alpha-protease and thermolysin. Isolation of fragments and determination of cleavage sites.
Endometriosis
Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor.
Endotoxemia
Alternative pathways for angiotensin II production as an important determinant of kidney damage in endotoxemia.
Epstein-Barr Virus Infections
A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection.
Favism
Oxidative inactivation of the calcium-stimulated neutral proteinase from human red blood cells by divicine and intracellular protection by reduced glutathione.
Gingivitis
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study.
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Glioblastoma
Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells.
Glioma
Hydrogen Peroxide-Induced Oxidative Stress Activates Proteasomal Trypsin-Like Activity in Human U373 Glioma Cells.
Glomerulonephritis
Renal expression of matrix metalloproteinases in human ANCA-associated glomerulonephritis.
Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.
Granuloma
Proteoglycan degrading activity in granulomatous inflammation: comparison between the C57b1/6 and C57bg/bg mouse.
Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice.
Heart Failure
Mast cell-derived cathepsin g: a possible role in the adverse remodeling of the failing human heart.
Hemangioendothelioma
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Hematologic Neoplasms
p53 abnormalities in B-cell prolymphocytic leukemia.
Hepatitis C, Chronic
Prevalence of ANCA in mixed cryoglobulinemia and chronic hepatitis C virus infection.
HIV Infections
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.
Thrombin activates envelope glycoproteins of HIV type 1 and enhances fusion.
Hyperalgesia
Up-regulation of Cathepsin G in the Development of Chronic Postsurgical Pain: An Experimental and Clinical Genetic Study.
Hyperhomocysteinemia
Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats.
Hypersensitivity
Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice.
Hypertension
Effect of acetaldehyde upon cathepsin G and chymase. NRAS implications.
Mast cell derived carboxypeptidase A3 is decreased among patients with advanced coronary artery disease.
Infections
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice.
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.
Effect of E. faecalis on the release of serine proteases elastase and cathepsin G, and collagenase-2 (MMP-8) by human polymorphonuclear leukocytes (PMNs).
Elastase and cathepsin G activities are present in immature bone marrow neutrophils and absent in late marrow and circulating neutrophils of beige (Chediak-Higashi) mice.
Human proteinase 3 resistance to inhibition extends to alpha-2 macroglobulin.
Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase.
Inhibition of U-937 membrane-associated cathepsin G by GP120 (IIIB) and V3 loop-derived peptides from several strains of HIV-1.
Inhibitors of elastase and cathepsin G in Chédiak-Higashi (beige) neutrophils.
Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein.
Lysosomal enzymes from polymorphonuclear leukocytes and proteinase inhibitors in patients with cystic fibrosis.
Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice.
Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain.
Nonchromogenic hydrolysis of elastase and cathepsin G p-nitroanilide substrates by Pseudomonas aeruginosa elastase.
Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases.
Targeted disruption of SPI3/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke.
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.
The effects of Fasciola hepatica infection on the total antioxidant status (TAS) and the activity of proteases and their inhibitors in rat serum.
The elimination of Anaplasma phagocytophilum requires CD4+ T cells, but is independent of Th1 cytokines and a wide spectrum of effector mechanisms.
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Inflammatory Bowel Diseases
Antineutrophil cytoplasmic antibodies (ANCAs) in patients with inflammatory bowel disease show no correlation with proteinase 3, lactoferrin, myeloperoxidase, elastase, cathepsin G and lysozyme: a Singapore study.
Antineutrophil cytoplasmic antibodies in primary sclerosing cholangitis: defined specificities may be associated with distinct clinical features.
Influenza, Human
Critical Role of SerpinB1 in Regulating Inflammatory Responses in Pulmonary Influenza Infection.
Ischemic Stroke
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Joint Diseases
Influence of some natural and semisynthetic agents on elastase and cathepsin G from polymorphonuclear granulocytes.
The degradation of articular collagen by neutrophil proteinases.
Keloid
Expression of Cathepsins B, D, and G by the Embryonic Stem Cell-Like Population within Human Keloid Tissues and Keloid-Derived Primary Cell Lines.
Keratoconus
Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas.
Is the corneal degradation in keratoconus caused by matrix-metalloproteinases?
Leg Ulcer
Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers.
Leukemia
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia.
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences.
An enzyme immunoassay of human polymorphonuclear leukocyte cathepsin G.
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin.
Corynebacterium parvum, but not BCG, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice.
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
Immunocytochemical identification of abnormal polymorphonuclear neutrophils in patients with leukemia.
Increased plasma proteinase activity of mice bearing the BCL1 leukemia.
Plasma levels of human granulocytic elastase alpha 1-proteinase inhibitor complex (E-alpha 1-PI) in leukemia.
PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
Role of promyelocytic leukemia (PML) protein in tumor suppression.
The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Erythroblastic, Acute
Murine erythroleukemia cell differentiation: possible involvement of a calcium dependent neutral proteinase.
Leukemia, Lymphocytic, Chronic, B-Cell
p53 abnormalities in B-cell prolymphocytic leukemia.
Leukemia, Lymphoid
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g.
[Lysosomal enzyme activity in white blood cells in leukemias]
Leukemia, Myeloid
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.
Purification and characterization of a vimentin-specific protease in mouse myeloid leukemia cells. Regulation during differentiation and identity with cathepsin G.
Targeting cathepsin G in myeloid leukemia.
Leukemia, Myeloid, Acute
A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia.
AML1-ETO targets and suppresses cathepsin G, a serine protease, which is able to degrade AML1-ETO in t(8;21) acute myeloid leukemia.
Cathepsin G is broadly expressed in acute myeloid leukemia and is an effective immunotherapeutic target.
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Leukemia, Promyelocytic, Acute
Adaptive immunity cooperates with liposomal all-trans-retinoic acid (ATRA) to facilitate long-term molecular remissions in mice with acute promyelocytic leukemia.
All-trans retinoic acid rapidly decreases cathepsin G synthesis and mRNA expression in acute promyelocytic leukemia.
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression.
The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites.
Lung Diseases
Airway proteins involved in bacterial clearance susceptible to cathepsin G proteolysis.
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement.
Protection of lung epithelial cells from protease-mediated injury by trappin-2 A62L, an engineered inhibitor of neutrophil serine proteases.
Separation of closely related peptide substrates of human proteinases by micellar electrokinetic chromatography with anionic and nonionic surfactants.
Lung Injury
Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice.
Suppression of superantigen-induced lung injury and vasculitis by preadministration of human urinary trypsin inhibitor.
Lung Neoplasms
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Lupus Erythematosus, Systemic
Anti-neutrophil cytoplasmic antibodies in childhood systemic lupus erythematosus.
Antibodies to human myeloperoxidase in glomerular immune deposits of systemic lupus erythematosus.
Defensins- and cathepsin G-ANCA in systemic lupus erythematosus.
Lupus Nephritis
Antineutrophil cytoplasmic autoantibodies (ANCA) and their target antigens in Chinese patients with lupus nephritis.
Lymphatic Metastasis
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Malaria
Anti-neutrophil cytoplasmic antibody (ANCA) in malaria is directed against cathepsin G.
Malnutrition
Effect of protein energy malnutrition on neutral proteinase in developing rat brain.
Mastocytoma
Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases.
Melanoma
Corynebacterium parvum, but not BCG, induces elevations in plasma proteinase activity similar to those observed in tumor-bearing mice.
Evidence that the elevated levels of proteinase activity in the plasma of melanoma-bearing mice may be of host origin.
Expression of melanoma neutral proteinase and collagenase potential by endocytosis.
Melanoma, Experimental
Differences between beige and bg/+ mice in the disruption of plasma proteinase regulation in the tumor-bearing state or following Corynebacterium parvum treatment. Evidence for the involvement of polymorphonuclear leukocyte proteinases.
Multiple Sclerosis
A Tolerogenic Role of Cathepsin G in a Primate Model of Multiple Sclerosis: Abrogation by Epstein-Barr Virus Infection.
Baisc protein hydrolysis in lymphocytes of Lewis rats with experimental allergic encephalomyelitis.
Increased calpain expression in experimental demyelinating optic neuritis: an immunocytochemical study.
Leucocyte proteinase activity and acute multiple sclerosis.
Lysosomal hydrolases in cerebrospinal fluid of multiple sclerosis patients. A follow-up study.
Proteolytic activity in CSF.
Muscular Dystrophies
Elevated activity of a neutral proteinase in human muscular dystrophy.
Mycoses
Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G.
Myocardial Ischemia
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Neoplasm Metastasis
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
[Comparative proteomics of the serum in patients with nasopharyngeal carcinoma: a study with two-dimensional electrophoresis and MALDI-TOF-MS]
Neoplasms
12-o-Tetradecanoyl-phorbol-13-acetate-differentiated U937 cells express a macrophage-like profile of neutral proteinases. High levels of secreted collagenase and collagenase inhibitor accompany low levels of intracellular elastase and cathepsin G.
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesis.
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D.
Bone hemangioendothelioma: an immunohistochemical study related to histological malignancy and proliferative activity (NORs).
Cathepsin G and alpha 1-antichymotrypsin in the local host reaction to loosening of total hip prostheses.
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.
Cathepsin G, a neutrophil protease, induces compact cell-cell adhesion in MCF-7 human breast cancer cells.
Cathepsin G-mediated activation of pro-matrix metalloproteinase 9 at the tumor-bone interface promotes transforming growth factor-beta signaling and bone destruction.
Cathepsin G-mediated enhanced TGF-beta signaling promotes angiogenesis via upregulation of VEGF and MCP-1.
Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells.
Comparison of the effects of auranofin and retinoic acid on plasminogen activator activity of peritoneal macrophages and Lewis lung carcinoma cells.
Connective tissue degradation by invasive rat bladder carcinomas: action of nonspecific proteinases on collagenous matrices.
Different Protein Expressions between Peripheral Ameloblastoma and Oral Basal Cell Carcinoma Occurred at the Same Mandibular Molar Area.
Dissection of laminin by cathepsin G into its long-arm and short-arm structures and localization of regions involved in calcium dependent stabilization and self-association.
Expression and Localization of Cathepsins B, D, and G in Two Cancer Stem Cell Subpopulations in Moderately Differentiated Oral Tongue Squamous Cell Carcinoma.
Few smokers develop COPD. Why?
Identification of proteases involved in the proteolysis of vascular endothelium cadherin during neutrophil transmigration.
Induction of neutral proteinase and prostanoid production in bovine nasal chondrocytes by interleukin-1 and tumor necrosis factor alpha: modulation of these cellular responses by interleukin-6 and platelet-derived growth factor.
Markedly elevated cell turnover is characteristic of small, deeply invasive carcinomas of the colorectum.
Mechanisms Governing Anaphylaxis: Inflammatory Cells, Mediators, Endothelial Gap Junctions and Beyond.
Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity.
Neutrophil extracellular trap formation in supragingival biofilms.
Processing of human cathepsin G after transfection to the rat basophilic/mast cell tumor line RBL.
Purification and further characterization of the Ca2+-activated proteinase specific for the intermediate filament proteins vimentin and desmin.
Role of promyelocytic leukemia (PML) protein in tumor suppression.
The Crosstalk Between Cancer Cells and Neutrophils Enhances Hepatocellular Carcinoma Metastasis via Neutrophil Extracellular Traps-Associated Cathepsin G Component: A Potential Therapeutic Target.
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Tumor cell metastasis and surface neutral proteinase: effects of antimetastatic and antitumor drugs.
Tumor necrosis factor-alpha enhances platelet activation via cathepsin G released from neutrophils.
Tumor necrosis factor-alpha-induced proteolytic activation of pro-matrix metalloproteinase-9 by human skin is controlled by down-regulating tissue inhibitor of metalloproteinase-1 and mediated by tissue-associated chymotrypsin-like proteinase.
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression.
Nephritis
Different mediator systems in biphasic heterologous phase of anti-GBM nephritis in mice.
Neuroinflammatory Diseases
The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease.
Osteoarthritis
Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids.
Quantitative analysis of elastase and cathepsin G mRNA levels in peripheral blood CD14(+) cells from patients with rheumatoid arthritis.
Significant correlation between thrombospondin 1 and serine proteinase expression in rheumatoid synovium.
Osteolysis
Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand.
Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1.
Osteomyelitis
The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomyelitis in a Spanish population.
Pancreatitis
Absence of the neutrophil serine protease cathepsin G decreases neutrophil granulocyte infiltration but does not change the severity of acute pancreatitis.
Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin.
Inhibition of neutrophil proteinases by recombinant serpin Lex032 reduces capillary no-reflow in ischemia/reperfusion-induced acute pancreatitis.
Release of dog polymorphonuclear leukocyte cathepsin G, normally and in endotoxin and pancreatitic shock. Isolation and partial characterization of dog polymorphonuclear leukocyte cathepsin G.
Periodontal Diseases
Cytopathic effects of Treponema denticola chymotrypsin-like proteinase on migrating and stratified epithelial cells.
Salivary levels of alpha 2-macroglobulin, alpha 1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease.
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Periodontal Pocket
Relationship of collagenase and cathepsin G activity in gingival crevicular fluid.
Periodontitis
Acute myocardial infarction elevates serine protease activity in saliva of patients with periodontitis.
Cathepsin G in gingival tissue and crevicular fluid in adult periodontitis.
Cellular source, activation and inhibition of dental plaque collagenase.
Cleaved inflammatory lactoferrin peptides in parotid saliva of periodontitis patients.
Identification and possible function of cathepsin G in gingival crevicular fluid from chronic adult periodontitis patients and from experimental gingivitis subjects.
Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva.
Infection and apoptosis associated with inflammation in periodontitis: An immunohistologic study.
The defensive role of lysozyme in human gingiva in inflammatory periodontal disease.
Peritonitis
Purification and N-terminal amino-acid sequence analysis of rat polymorphonuclear leukocyte cathepsin G.
Plague
[Flow-cytofluorometric study of bactericidal granules in blood phagocytes of animals with various species sensitivity to experimental plague infection].
Pneumonia
Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry.
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation.
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Inflammatory response to particles in the rat lung: secretion of acid and neutral proteinases by bronchoalveolar leucocytes.
Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors.
Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases.
Pneumonia, Pneumocystis
Collagenases and the serine proteinases elastase and cathepsin G in steroid-induced Pneumocystis carinii pneumonia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cathepsin G Is Expressed by Acute Lymphoblastic Leukemia and Is a Potential Immunotherapeutic Target.
Prostatic Neoplasms
Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models.
Protein-Energy Malnutrition
Effect of protein energy malnutrition on neutral proteinase in developing rat brain.
Proteinuria
Studies on the glomerular filtration barrier and on the urinary excretion of basement membrane glycoproteins during the accelerated model of nephrotoxic serum nephritis.
The human neutrophil serine proteinases, elastase and cathepsin G, can mediate glomerular injury in vivo.
Psoriasis
Cathepsin G cleaves and activates IL-36? and promotes the inflammation of psoriasis.
Downregulation of interleukin 36? and its cleaver cathepsin G following treatment with narrow-band ultraviolet B phototherapy in psoriasis vulgaris.
Inhibition of Neutrophil Elastase and Cathepsin G As a New Approach to the Treatment of Psoriasis: From Fundamental Biology to Development of New Target-Specific Drugs.
Neutral proteinases and other neutrophil enzymes in psoriasis, and their relation to disease activity.
The activity of polymorphonuclear leukocyte neutral proteinases and their inhibitors in patients with psoriasis treated with a continuous peritoneal dialysis.
Pulmonary Disease, Chronic Obstructive
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
Cathepsin G degradation of phospholipid transfer protein (PLTP) augments pulmonary inflammation.
Dual Inhibition of Cathepsin G and Chymase is Effective in Animal Models of Pulmonary Inflammation.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Lung tissue destruction by proteinase 3 and cathepsin G mediated elastin degradation is elevated in chronic obstructive pulmonary disease.
Proteases and antiproteases.
Proteinase/proteinase inhibitor imbalance in sputum sol phases from patients with chronic obstructive pulmonary disease. Suggestions for a key role played by antileukoprotease.
Pulmonary Edema
Using a Caesalpinia echinata Lam. protease inhibitor as a tool for studying the roles of neutrophil elastase, cathepsin G and proteinase 3 in pulmonary edema.
Pulmonary Emphysema
Leukoproteinases and pulmonary emphysema: cathepsin G and other chymotrypsin-like proteinases enhance the elastolytic activity of elastase on lung elastin.
Novel anthraquinone inhibitors of human leukocyte elastase and cathepsin G.
Structure, function, and control of neutrophil proteinases.
Purpura
[Activities of proteinases in invertebrate animals--potential objects of fish nutrition. Effects of temperature, pH, and heavy metals]
Renal Insufficiency, Chronic
Elastase and cathepsin G from primed leukocytes cleave vascular endothelial cadherin in hemodialysis patients.
Reperfusion Injury
Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury.
Respiratory Distress Syndrome
Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G.
Internally quenched fluorogenic substrates with unnatural amino acids for cathepsin G investigation.
Sarcoma
[Neutral proteinase of transplantable sarcoma tissue from rats]
Sarcoma, Avian
Purification and properties of extracellular matrix-degrading metallo-proteinase overproduced by Rous sarcoma virus-transformed rat liver cell line, and its identification as transin.
Sarcoma, Yoshida
Cartilage-degrading neutral proteinase secreted by Yoshida sarcoma cells. Purification and properties.
Scleroderma, Diffuse
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Scleroderma, Limited
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Scleroderma, Systemic
Autoantibodies to bactericidal/permeability-increasing protein and cathepsin G in systemic sclerosis.
Bactericidal/permeability-increasing protein and cathepsin G are the major antigenic targets of antineutrophil cytoplasmic autoantibodies in systemic sclerosis.
[Prevalence and clinical significance of cathepsin G antibodies in systemic sclerosis]
Sepsis
Effect of various genetic polymorphisms on the incidence and outcome of severe sepsis.
Human leukocyte elastase and cathepsin G inactivate factor VII by limited proteolysis.
Identification of a 14kDa endocan fragment generated by cathepsin G, a novel circulating biomarker in patients with sepsis.
Protease inhibitors protect macrophages from lipopolysaccharide-induced cytotoxicity: possible role for NF-kappaB.
Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects.
Shock, Septic
Therapeutic effects of the combination of two proteinase inhibitors in endotoxin shock of the pig.
Silicosis
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
[Comparative analysis of serum proteomic profiles between patients with silicosis and chronic bronchitis].
Sjogren's Syndrome
Normal but not altered mucins activate neutrophils.
Skin Diseases
Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
Small Cell Lung Carcinoma
Activity and tissue localization of cathepsin G in non small cell lung cancer.
Squamous Cell Carcinoma of Head and Neck
Bioinformatics Analyses Indicate That Cathepsin G (CTSG) is a Potential Immune-Related Biomarker in Oral Squamous Cell Carcinoma (OSCC).
ST Elevation Myocardial Infarction
Low-grade endotoxaemia enhances artery thrombus growth via Toll-like receptor 4: implication for myocardial infarction.
Subarachnoid Hemorrhage
Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage.
Thrombosis
Activities of proteases in parietal thrombus of aortic aneurysm.
Cathepsin g-dependent modulation of platelet thrombus formation in vivo by blood neutrophils.
Characterization of polymorphic structure of cathepsin G gene: role in cardiovascular and cerebrovascular diseases.
Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents.
Hemorphin 7 reflects hemoglobin proteolysis in abdominal aortic aneurysm.
Human neutrophil cathepsin G is a potent platelet activator.
Neutrophil cathepsin G modulates platelet P-selectin expression and inhibits P-selectin-mediated platelet-neutrophil adhesion.
Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex.
Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions.
Protease-activated receptor 4: a critical participator in inflammatory response.
Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Tuberculosis
Cathepsin G in Experimental Tuberculosis: Relevance for Antibacterial Protection and Potential for Immunotherapy.
Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages.
The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.
[Changes in serum protease and cytokine in patients with silicosis, tuberculosis, and lung cancer].
Urticaria
Heterozygous alpha 1-antichymotrypsin deficiency may be associated with cold urticaria.
Urticaria Pigmentosa
Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.
Uterine Cervical Neoplasms
Up-regulation of 5-lipoxygenase by inhibition of cathepsin G enhances TRAIL-induced apoptosis through down-regulation of survivin.
Vascular System Injuries
Cathepsin G activates protease-activated receptor-4 in human platelets.
Neutrophil derived cathepsin G induces potentially thrombogenic changes in human endothelial cells: a scanning electron microscopy study in static and dynamic conditions.
Vasculitis
Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Cutaneous vasculitis in breast cancer treated with chemotherapy.
Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries.
Venous Thrombosis
Inhibition by heparin of platelet activation induced by neutrophil-derived cathepsin G.
Vitamin A Deficiency
Neutrophil cathepsin G is specifically decreased under vitamin A deficiency.
Whooping Cough
Cathepsin G, a neutrophil-derived serine protease, increases susceptibility of macrophages to acute human immunodeficiency virus type 1 infection.