Reference on EC 3.4.21.112 - site-1 protease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Seidah, N.G.; Benjannet, S.; Hamelin, J.; Mamarbachi, A.M.; Basak, A.; Marcinkiewicz, J.; Mbikay, M.; Chretien, M.; Marcinkiewicz, M.
The subtilisin/kexin family of precursor convertases. Emphasis on PC1, PC2/7B2, POMC and the novel enzyme SKI-1
Ann. N. Y. Acad. Sci.
885
57-74
1999
Rattus norvegicus
DeBose-Boyd, R.A.; Brown, M.S.; Li, W.P.; Nohturfft, A.; Goldstein, J.L.; Espenshade, P.J.
Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi
Cell
99
703-712
1999
Cricetulus griseus
Basak, A.; Chretien, M.; Seidah, N.G.
A rapid fluorometric assay for the proteolytic activity of SKI-1/S1P based on the surface glycoprotein of the hemorrhagic fever Lassa virus
FEBS Lett.
514
333-339
2002
Homo sapiens
Espenshade, P.J.; Cheng, D.; Goldstein, J.L.; Brown, M.S.
Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins
J. Biol. Chem.
274
22795-22804
1999
Cricetulus griseus
Cheng, D.; Espenshade, P.J.; Slaughter, C.A.; Jaen, J.C.; Brown, M.S.; Goldstein, J.L.
Secreted site-1 protease cleaves peptides corresponding to luminal loop of sterol regulatory element-binding proteins
J. Biol. Chem.
274
22805-22812
1999
Mammalia
Toure, B.B.; Munzer, J.S.; Basak, A.; Benjannet, S.; Rochemont, J.; Lazure, C.; Chretien, M.; Seidah, N.G.
Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment
J. Biol. Chem.
275
2349-2358
2000
Homo sapiens
Vincent, M.J.; Sanchez, A.J.; Erickson, B.R.; Basak, A.; Chretien, M.; Seidah, N.G.; Nichol, S.T.
Crimean-Congo hemorrhagic fever virus glycoprotein proteolytic processing by subtilase SKI-1
J. Virol.
77
8640-8649
2003
Homo sapiens
Seidah, N.G.; Mowla, S.J.; Hamelin, J.; Mamarbachi, A.M.; Benjannet, S.; Toure, B.B.; Basak, A.; Munzer, J.S.; Marcinkiewicz, J.; Zhong, M.; Barale, J.C.; Lazure, C.; Murphy, R.A.; Chretien, M.; Marcinkiewicz, M.
Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization
Proc. Natl. Acad. Sci. USA
96
1321-1326
1999
Homo sapiens, Rattus norvegicus (Q9WTZ3)
Basak, S.; Stewart, N.A.; Chretien, M.; Basak, A.
Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac-VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme-1
FEBS Lett.
573
186-194
2004
Homo sapiens
Shen, J.; Prywes, R.
Dependence of site-2 protease cleavage of ATF6 on prior site-1 protease digestion is determined by the size of the luminal domain of ATF6
J. Biol. Chem.
279
43046-43051
2004
Homo sapiens
Seidah, N.G.; Chretien, M.
Proprotein convertase SKI-1/SIP
Handbook of Proteolytic Enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , Eds. ) Academic Press
2
1845-1847
2004
Arabidopsis thaliana, Cricetulus griseus, Homo sapiens, Mus musculus, Oryza sativa, Rattus norvegicus
-
Sanchez, A.J.; Vincent, M.J.; Erickson, B.R.; Nichol, S.T.
Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein
J. Virol.
80
514-525
2006
Homo sapiens
Stirling, J.; OHare, P.
CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P
Mol. Biol. Cell
17
413-426
2005
Homo sapiens
Ye, J.; Rawson, R.B.; Komuro, R.; Chen, X.; Dave, U.P.; Prywes, R.; Brown, M.S.; Goldstein, J.L.
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
Mol. Cell
6
1355-1364
2000
Cricetulus griseus
Lenz, O.; Ter Meulen, J.; Klenk, H.D.; Seidah, N.G.; Garten, W.
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
Proc. Natl. Acad. Sci. USA
98
12701-12702
2001
Homo sapiens
Hay, B.A.; Abrams, B.; Zumbrunn, A.Y.; Valentine, J.J.; Warren, L.C.; Petras, S.F.; Shelly, L.D.; Xia, A.; Varghese, A.H.; Hawkins, J.L.; Van Camp, J.A.; Robbins, M.D.; Landschulz, K.; Harwood, H.J.
Aminopyrrolidineamide inhibitors of site-1 protease
Bioorg. Med. Chem. Lett.
17
4411-4414
2007
Homo sapiens
De Windt, A.; Rai, M.; Bernier, L.; Thelen, K.; Soini, J.; Lefebvre, C.; Chintawar, S.; Lavigne, J.; Saarinen, L.; Kytoemaeki, L.; Munzer, J.S.; Luetjohann, D.; Pandolfo, M.; Davignon, J.; Seidah, N.G.; Laaksonen, R.
Gene Set Enrichment Analysis Reveals Several Globally Affected Pathways due to SKI-1/S1P Inhibition in HepG2 Cells
DNA Cell Biol.
26
765-772
2007
Homo sapiens
Ellermeier, C.D.; Losick, R.
Evidence for a novel protease governing regulated intramembrane proteolysis and resistance to antimicrobial peptides in Bacillus subtilis
Genes Dev.
20
1911-1922
2006
Bacillus subtilis, Bacillus subtilis PY79
Pullikotil, P.; Benjannet, S.; Mayne, J.; Seidah, N.G.
The proprotein convertase SKI-1/S1P: Alternate translation and subcellular localization
J. Biol. Chem.
282
27402-27413
2007
Homo sapiens
Patra, D.; Xing, X.; Davies, S.; Bryan, J.; Franz, C.; Hunziker, E.B.; Sandell, L.J.
Site-1 protease is essential for endochondral bone formation in mice
J. Cell Biol.
179
687-700
2007
Mus musculus
Bergeron, E.; Vincent, M.J.; Nichol, S.T.
Crimean-Congo hemorrhagic fever virus glycoprotein processing by the endoprotease SKI-1/S1P is critical for virus infectivity
J. Virol.
81
13271-13276
2007
Homo sapiens
Heinrich, J.; Wiegert, T.
YpdC determines site-1 degradation in regulated intramembrane proteolysis of the RsiW anti-sigma factor of Bacillus subtilis
Mol. Microbiol.
62
566-579
2006
Bacillus subtilis
Bodvard, K.; Mohlin, J.; Knecht, W.
Recombinant expression, purification, and kinetic and inhibitor characterisation of human site-1-protease
Protein Expr. Purif.
51
308-319
2007
Homo sapiens
Buraczewska, I.; Berne, B.; Lindberg, M.; Loden, M.; Toermae, H.
Long-term treatment with moisturizers affects the mRNA levels of genes involved in keratinocyte differentiation and desquamation
Arch. Dermatol. Res.
301
175-181
2009
Rattus norvegicus
Hawkins, J.L.; Robbins, M.D.; Warren, L.C.; Xia, D.; Petras, S.F.; Valentine, J.J.; Varghese, A.H.; Wang, I.K.; Subashi, T.A.; Shelly, L.D.; Hay, B.A.; Landschulz, K.T.; Geoghegan, K.F.; Harwood, H.J.
Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals
J. Pharmacol. Exp. Ther.
326
801-808
2008
Homo sapiens (Q14703), Homo sapiens
Rojek, J.M.; Lee, A.M.; Nguyen, N.; Spiropoulou, C.F.; Kunz, S.
Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito
J. Virol.
82
6045-6051
2008
Homo sapiens
Matthews, K.; Kunte, A.; Tambe-Ebot, E.; Rawson, R.
Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster
Genetics
181
119-128
2009
Drosophila melanogaster
Yellaturu, C.; Deng, X.; Park, E.; Raghow, R.; Elam, M.
Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptionaldown-regulation of insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP)SREBP-1c complex
J. Biol. Chem.
284
31726-31734
2009
Rattus norvegicus
Amarneh, B.; Matthews, K.A.; Rawson, R.B.
Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae
J. Biol. Chem.
284
9674-9682
2009
Drosophila melanogaster
Maisa, A.; Stroeher, U.; Klenk, H.D.; Garten, W.; Strecker, T.
Inhibition of Lassa virus glycoprotein cleavage and multicycle replication by site 1 protease-adapted alpha(1)-antitrypsin variants
PLoS Negl. Trop. Dis.
3
e446
2009
Cricetulus griseus (Q9Z2A8)
Basak, A.; Mitra, D.; Das, A.K.; Mohottalage, D.; Basak, A.
C2-Symmetric azobenzene-amino acid conjugates and their inhibition of Subtilisin Kexin Isozyme-1
Bioorg. Med. Chem. Lett.
20
3977-3981
2010
Homo sapiens
Zandberg, W.F.; Benjannet, S.; Hamelin, J.; Pinto, B.M.; Seidah, N.G.
N-glycosylation controls trafficking, zymogen activation and substrate processing of proprotein convertases PC1/3 and subtilisin kexin isozyme-1
Glycobiology
21
1290-1300
2011
Homo sapiens
Patra, D.; DeLassus, E.; Hayashi, S.; Sandell, L.J.
Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice
J. Biol. Chem.
286
29227-29240
2011
Mus musculus
Urata, S.; Yun, N.; Pasquato, A.; Paessler, S.; Kunz, S.; de la Torre, J.C.
Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease
J. Virol.
85
795-803
2011
Homo sapiens
Da Palma, J.; Burri, D.; Oppliger, J.; Salamina, M.; Cendron, L.; De Laureto, P.; Seidah, N.; Kunz, S.; Pasquato, A.
Zymogen activation and subcellular activity of subtilisin kexin isozyme 1/site 1 protease
J. Biol. Chem.
289
35743-35756
2014
Homo sapiens (Q14703)
Weiss, N.; Stegemann, A.; Elsayed, M.A.; Schallreuter, K.U.; Luger, T.A.; Loser, K.; Metze, D.; Weishaupt, C.; Boehm, M.
Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells
J. Invest. Dermatol.
134
168-175
2014
Homo sapiens (Q14703), Homo sapiens
Burri, D.; Pasqual, G.; Rochat, C.; Seidah, N.; Pasquato, A.; Kunz, S.
Molecular characterization of the processing of arenavirus envelope glycoprotein precursors by subtilisin kexin isozyme-1/site-1 protease
J. Virol.
86
4935-4946
2012
Homo sapiens (Q14703)
Burri, D.; da Palma, J.; Seidah, N.; Zanotti, G.; Cendron, L.; Pasquato, A.; Kunz, S.
Differential recognition of old world and new world arenavirus envelope glycoproteins by subtilisin kexin isozyme 1 (SKI-1)/site 1 protease (S1P)
J. Virol.
87
6406-6414
2013
Homo sapiens (Q14703), Homo sapiens
Sun, L.; Zhang, S.S.; Lu, S.J.; Liu, J.X.
Site-1 protease cleavage site is important for the ER stress-induced activation of membrane-associated transcription factor bZIP28 in Arabidopsis
Sci. China Life Sci.
58
270-275
2015
Arabidopsis thaliana
Patra, D.; DeLassus, E.; Mueller, J.; Abou-Ezzi, G.; Sandell, L.J.
Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice
Biol. Open
7
bio032094
2018
Mus musculus
Nakagawa, T.; Suzuki-Nakagawa, C.; Watanabe, A.; Asami, E.; Matsumoto, M.; Nakano, M.; Ebihara, A.; Uddin, M.N.; Suzuki, F.
Site-1 protease is required for the generation of soluble (pro)renin receptor
J. Biochem.
161
369-379
2017
Cricetulus griseus
Kluender, S.; Heeren, J.; Markmann, S.; Santer, R.; Braulke, T.; Pohl, S.
Site-1 protease-activated formation of lysosomal targeting motifs is independent of the lipogenic transcription control
J. Lipid Res.
56
1625-1632
2015
Homo sapiens, Mus musculus
Schweitzer, G.; Gan, C.; Bucelli, R.; Wegner, D.; Schmidt, R.; Shinawi, M.; Finck, B.; Brookheart, R.
A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema
Mol. Genet. Genomic Med.
2019
e733
2019
Homo sapiens
Hyrina, A.; Meng, F.; McArthur, S.J.; Eivemark, S.; Nabi, I.R.; Jean, F.
Human subtilisin kexin isozyme-1 (SKI-1)/Site-1 Protease (S1P) regulates cytoplasmic lipid droplet abundance A potential target for indirect-acting anti-dengue virus agents
PLoS ONE
12
e0174483
2017
Homo sapiens
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