Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 3.4.21.10 - acrosin

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Asthenozoospermia
Acrosin activity of human spermatozoa by means of a simple gelatinolytic technique: a method useful for IVF.
[L-carnitine improves sperm acrosin activity in male infertility patients].
Breast Neoplasms
Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.
Carcinoma, Ductal
Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.
Fibroadenoma
Upregulation of RHOXF2 and ODF4 Expression in Breast Cancer Tissues.
Herpes Zoster
A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats.
A mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein.
Acrosin accelerates the dispersal of sperm acrosomal proteins during acrosome reaction.
Acrosin activity in patients with idiopathic infertility.
Acrosin Activity Regulation by Protein Kinase C and Tyrosine Kinase in Bovine Sperm Acrosome Exocytosis Induced by Lysophosphatidylcholine.
Acrosin is essential for sperm penetration through the zona pellucida in hamsters.
Acrosin shows zona and fucose binding, novel properties for a serine proteinase.
Activation and subsequent degradation of proacrosin is mediated by zona pellucida glycoproteins, negatively charged polysaccharides, and DNA.
Antifertility effects of tetradecyl sodium sulphate in rabbits.
Appropriate timing of the acrosome reaction is a major requirement for the fertilizing spermatozoon.
Boar acrosin digestion of the porcine egg coat, zona pellucida, and rearrangement of the zona proteins.
Caprine acrosin. Purification, characterization and proteolysis of the porcine zona pellucida.
Cell biology of acrosomal proteins.
Changes in composition of the porcine zona pellucida during development of the oocyte to the 2- to 4-cell embryo.
Characterization of the functional domains of boar acrosin involved in nonenzymatic binding to homologous zona pellucida glycoproteins.
Correction for Hirose et al., Acrosin is essential for sperm penetration through the zona pellucida in hamsters.
Diploid expression and translational regulation of rat acrosin gene.
Dissolution of rabbit zona by sperm acrosomal extract: effect of calcium (1).
Distinctive features of the gametes and reproductive tracts of the Asian musk shrew, Suncus murinus.
Early steps of sperm-egg interactions during mammalian fertilization.
Effect of recombinant boar beta-acrosin on sperm binding to intact zona pellucida during in vitro fertilization.
Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.
Effects of acrosin inhibitors on the soluble and membrane-bound forms of ram acrosin, and a reappraisal of the role of the enzyme in fertilization.
Effects of ram sperm acrosin on the investments of sheep, pig, mouse and gerbil eggs.
Functional interactions between sulphated polysaccharides and proacrosin: implications in sperm binding and digestion of zona pellucida.
Golden hamster perivitelline spermatozoa do not show proacrosin/acrosin at the inner acrosomal membrane.
Histochemical subcellular localization of the acrosomal proteinase effecting dissolution of the zona pellucida using fluorescein-labeled inhibitors.
Identification of a zona-binding protein from boar spermatozoa as proacrosin.
Immunocytochemical localization of acrosin on both acrosomal membranes and in the acrosomal matrix of porcine spermatozoa.
Immunodetection of acrosin during the acrosome reaction of hamster, guinea-pig and human spermatozoa.
Immunolocalization of proacrosin/acrosin in rabbit sperm during acrosome reaction and in spermatozoa recovered from the perivitelline space.
Inhibition of acrosin activity with a trypsin inhibitor blocks human sperm penetration of the zona pellucida.
Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa.
Limited and specific proteolysis of the zona pellucida by acrosin.
Limited proteolysis by acrosin affects sperm-binding and mechanical resilience of the mouse zona pellucida.
Limited proteolysis of the porcine zona pellucida by homologous sperm acrosin.
Localization of rabbit sperm acrosin during the acrosome reaction induced by immobilized zona matrix.
Mammalian sperm interaction with extracellular matrices of the egg.
Matrix degrading properties of sperm serine proteinase, acrosin.
Mechanical hypothesis of sperm penetration.
Methods to evaluate reproductive health of the human male.
MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization.
Molecular mechanisms of the interaction between sperm and the zona pellucida in mammals: studies on the pig.
Monoclonal antibodies to bovine and human acrosin.
Normal penetration of rabbit spermatozoa through a trypsin- and acrosin-resistant zona pellucida.
On the interaction of bull and boar acrosins with the zona pellucida of different mammalian species in vitro.
p-Aminobenzamidine, an acrosin inhibitor, inhibits mouse sperm penetration of the zona pellucida but not the acrosome reaction.
p-Aminobenzamidine-sensitive acrosomal protease(s) other than acrosin serve the sperm penetration of the egg zona pellucida in mouse.
PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida.
Predominance of beta-structure in solubilized zona pellucida from porcine ova.
Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility.
Protease activity involvement in the passage of mammalian sperm through the zona pellucida.
Proteolysis of specific porcine zona pellucida glycoproteins by boar acrosin.
Proteolysis of the zona pellucida by acrosin: the nature of the hydrolysis products.
Proteolytic activity of rabbit perivitelline spermatozoa.
Purification of mouse sperm acrosin, its activation from proacrosin and effect on homologous egg investments.
Randomized trial of partial zona dissection for male infertility.
Role of acrosomal matrix proteases in sperm-zona pellucida interactions.
Site-directed mutagenesis of rabbit proacrosin. Identification of residues involved in zona pellucida binding.
Some effects of zona pellucida glycoproteins and sulfated polymers on the autoactivation of boar sperm proacrosin and activity of beta-acrosin.
Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.
Spermatozoa lacking acrosin protein show delayed fertilization.
Subcellular immunochemical localization of acrosin in human spermatozoa during the acrosome reaction and zona pellucida penetration.
The action of acrosin on the zona pellucida.
The complete primary structure of three isoforms of a boar sperm-associated acrosin inhibitor.
The histochemical localization of acrosin in guinea-pig sperm after the acrosome reaction.
The inhibition of boar acrosin amidase activity by sulfated polysaccharides.
The interaction of boar sperm proacrosin with its natural substrate, the zona pellucida, and with polysulfated polysaccharides.
The molecular evolution of acrosin in placental mammals.
The morphological and molecular susceptibility of sheep and mouse zona pellucida to acrosin.
The polysulphate binding domain of human proacrosin/acrosin is involved in both the enzyme activation and spermatozoa-zona pellucida interaction.
The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins.
The sperm acrosome: functional and clinical aspects.
The structures of the bovine and porcine proacrosin genes and their conservation among mammals.
Ultrastructure of opossum oocyte investing coats and their sensitivity to trypsin and hyaluronidase.
Wheat germ agglutinin treatment of follicle cell-free mouse oocytes inhibits fertilization.
Zona pellucida induces conversion of proacrosin to acrosin.
Zona pellucida-binding and fucose-binding of boar sperm acrosin is not correlated with proteolytic activity.
Zona pellucida-binding of boar sperm acrosin is associated with the N-terminal peptide of the acrosin B-chain (heavy chain).
[Significance of proteolytic sperm enzymes for the fertility]
[The significance of acrosin and proteinase-inhibitors in human reproduction]
Infections
Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China.
[Automatic detection and clinical application of semen biochemical markers].
Infertility
A simple, clinical assay to evaluate the acrosin activity of human spermatozoa.
A study of sperm acrosin in patients with unexplained infertility.
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility.
Acrosin activity in patients with idiopathic infertility.
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities.
Acrosomal proteinase activity of human spermatozoa and relation of results to semen quality.
Adenosine 5 triphosphate (ATP) content and acrosin activity in polyzoospermic subjects.
Antisperm antibody binding to human acrosin: a study of patients with unexplained infertility.
Contribution of the male factor to unexplained infertility: a review.
Evidence of proacrosin molecule abnormality as a possible cause of low acrosin activity and unexplained failure of fertilization in vitro.
Gelatin-substrate film technique for detection of acrosin in single mammalian sperm.
High total acrosin activity in varicocele individuals.
Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity.
Is spermatozoan acrosin a predictor of fertilization and embryo quality in the human?
Long-term contraceptive efficacy of vaccine of ovine follicle-stimulating hormone in male bonnet monkeys (Macaca radiata).
Low acrosin activity in a subgroup of men with idiopathic infertility dose not correlate with sperm density, percent motility, curvilinear velocity, or linearity.
Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility.
Relation of human sperm acrosin activity and fertilization in vitro.
Relationship of acrosin activity to sperm function tests.
The Change of Semen Superoxide Dismutase and Acrosin Activity in the Sterility of Male Patients with Positive Antisperm Antibody.
[Indications for determination of acrosin]
[The effect of semen antisperm antibody on human sperm acrosin activity]
[Value of sperm acrosin activity detection in selecting the method of assisted reproduction for patients with unexplained infertility].
Infertility, Male
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility.
Acrosin activity in spermatozoa from sterile t6/tw32 and fertile control mice.
Gelatin-substrate film technique for detection of acrosin in single mammalian sperm.
The Change of Semen Superoxide Dismutase and Acrosin Activity in the Sterility of Male Patients with Positive Antisperm Antibody.
[Indications for determination of acrosin]
[L-carnitine improves sperm acrosin activity in male infertility patients].
[The effect of semen antisperm antibody on human sperm acrosin activity]
Neoplasms
Production, purification, and in vivo evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccine.
Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation.
[Effects of interferon-gamma and tumor necrosis factor-alpha on the fertilizing capacity of humam sperm and their mechanisms]
Oligospermia
Acrosin activity of human spermatozoa by means of a simple gelatinolytic technique: a method useful for IVF.
Determination of active, non-zymogen acrosin, proacrosin and total acrosin in different andrological patients.
[L-carnitine improves sperm acrosin activity in male infertility patients].
Polycystic Kidney Diseases
Characterization of sperm surface protein patterns of ejaculated and capacitated boar sperm, with the detection of ZP binding candidates.
Spinal Cord Injuries
Hyaluronic acid binding and acrosin activity are decreased in sperm from men with spinal cord injury.
Teratozoospermia
Evidence for effects of testis and epididymis expressed genes on sperm quality and boar fertility traits.
[Etiologic analysis of globozoospermia: a 1-case report]
[Indications for determination of acrosin]
Varicocele
"Human sperm physiology: estrogen receptor alpha (ER?) and estrogen receptor beta (ER?) influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male infertility."
Assessment of sperm functions in infertile patients with varicoceles.
High total acrosin activity in varicocele individuals.
The effect of smoking and varicocele on human sperm acrosin activity and acrosome reaction.