Disease on EC 3.4.21.10 - acrosin
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Asthenozoospermia
Acrosin activity of human spermatozoa by means of a simple gelatinolytic technique: a method useful for IVF.
Asthenozoospermia
[L-carnitine improves sperm acrosin activity in male infertility patients].
Herpes Zoster
A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats.
Herpes Zoster
A mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein.
Herpes Zoster
Acrosin accelerates the dispersal of sperm acrosomal proteins during acrosome reaction.
Herpes Zoster
Acrosin Activity Regulation by Protein Kinase C and Tyrosine Kinase in Bovine Sperm Acrosome Exocytosis Induced by Lysophosphatidylcholine.
Herpes Zoster
Acrosin is essential for sperm penetration through the zona pellucida in hamsters.
Herpes Zoster
Acrosin shows zona and fucose binding, novel properties for a serine proteinase.
Herpes Zoster
Activation and subsequent degradation of proacrosin is mediated by zona pellucida glycoproteins, negatively charged polysaccharides, and DNA.
Herpes Zoster
Appropriate timing of the acrosome reaction is a major requirement for the fertilizing spermatozoon.
Herpes Zoster
Boar acrosin digestion of the porcine egg coat, zona pellucida, and rearrangement of the zona proteins.
Herpes Zoster
Caprine acrosin. Purification, characterization and proteolysis of the porcine zona pellucida.
Herpes Zoster
Changes in composition of the porcine zona pellucida during development of the oocyte to the 2- to 4-cell embryo.
Herpes Zoster
Characterization of the functional domains of boar acrosin involved in nonenzymatic binding to homologous zona pellucida glycoproteins.
Herpes Zoster
Correction for Hirose et al., Acrosin is essential for sperm penetration through the zona pellucida in hamsters.
Herpes Zoster
Distinctive features of the gametes and reproductive tracts of the Asian musk shrew, Suncus murinus.
Herpes Zoster
Effect of recombinant boar beta-acrosin on sperm binding to intact zona pellucida during in vitro fertilization.
Herpes Zoster
Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.
Herpes Zoster
Effects of acrosin inhibitors on the soluble and membrane-bound forms of ram acrosin, and a reappraisal of the role of the enzyme in fertilization.
Herpes Zoster
Effects of ram sperm acrosin on the investments of sheep, pig, mouse and gerbil eggs.
Herpes Zoster
Functional interactions between sulphated polysaccharides and proacrosin: implications in sperm binding and digestion of zona pellucida.
Herpes Zoster
Golden hamster perivitelline spermatozoa do not show proacrosin/acrosin at the inner acrosomal membrane.
Herpes Zoster
Histochemical subcellular localization of the acrosomal proteinase effecting dissolution of the zona pellucida using fluorescein-labeled inhibitors.
Herpes Zoster
Immunocytochemical localization of acrosin on both acrosomal membranes and in the acrosomal matrix of porcine spermatozoa.
Herpes Zoster
Immunodetection of acrosin during the acrosome reaction of hamster, guinea-pig and human spermatozoa.
Herpes Zoster
Immunolocalization of proacrosin/acrosin in rabbit sperm during acrosome reaction and in spermatozoa recovered from the perivitelline space.
Herpes Zoster
Inhibition of acrosin activity with a trypsin inhibitor blocks human sperm penetration of the zona pellucida.
Herpes Zoster
Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa.
Herpes Zoster
Limited proteolysis by acrosin affects sperm-binding and mechanical resilience of the mouse zona pellucida.
Herpes Zoster
Limited proteolysis of the porcine zona pellucida by homologous sperm acrosin.
Herpes Zoster
Localization of rabbit sperm acrosin during the acrosome reaction induced by immobilized zona matrix.
Herpes Zoster
MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization.
Herpes Zoster
Molecular mechanisms of the interaction between sperm and the zona pellucida in mammals: studies on the pig.
Herpes Zoster
Normal penetration of rabbit spermatozoa through a trypsin- and acrosin-resistant zona pellucida.
Herpes Zoster
On the interaction of bull and boar acrosins with the zona pellucida of different mammalian species in vitro.
Herpes Zoster
p-Aminobenzamidine, an acrosin inhibitor, inhibits mouse sperm penetration of the zona pellucida but not the acrosome reaction.
Herpes Zoster
p-Aminobenzamidine-sensitive acrosomal protease(s) other than acrosin serve the sperm penetration of the egg zona pellucida in mouse.
Herpes Zoster
PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida.
Herpes Zoster
Predominance of beta-structure in solubilized zona pellucida from porcine ova.
Herpes Zoster
Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility.
Herpes Zoster
Protease activity involvement in the passage of mammalian sperm through the zona pellucida.
Herpes Zoster
Proteolysis of the zona pellucida by acrosin: the nature of the hydrolysis products.
Herpes Zoster
Purification of mouse sperm acrosin, its activation from proacrosin and effect on homologous egg investments.
Herpes Zoster
Site-directed mutagenesis of rabbit proacrosin. Identification of residues involved in zona pellucida binding.
Herpes Zoster
Some effects of zona pellucida glycoproteins and sulfated polymers on the autoactivation of boar sperm proacrosin and activity of beta-acrosin.
Herpes Zoster
Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.
Herpes Zoster
Subcellular immunochemical localization of acrosin in human spermatozoa during the acrosome reaction and zona pellucida penetration.
Herpes Zoster
The complete primary structure of three isoforms of a boar sperm-associated acrosin inhibitor.
Herpes Zoster
The histochemical localization of acrosin in guinea-pig sperm after the acrosome reaction.
Herpes Zoster
The interaction of boar sperm proacrosin with its natural substrate, the zona pellucida, and with polysulfated polysaccharides.
Herpes Zoster
The morphological and molecular susceptibility of sheep and mouse zona pellucida to acrosin.
Herpes Zoster
The polysulphate binding domain of human proacrosin/acrosin is involved in both the enzyme activation and spermatozoa-zona pellucida interaction.
Herpes Zoster
The serine protease testisin is present on the surface of capacitated stallion spermatozoa and interacts with key zona pellucida binding proteins.
Herpes Zoster
The structures of the bovine and porcine proacrosin genes and their conservation among mammals.
Herpes Zoster
Ultrastructure of opossum oocyte investing coats and their sensitivity to trypsin and hyaluronidase.
Herpes Zoster
Wheat germ agglutinin treatment of follicle cell-free mouse oocytes inhibits fertilization.
Herpes Zoster
Zona pellucida-binding and fucose-binding of boar sperm acrosin is not correlated with proteolytic activity.
Herpes Zoster
Zona pellucida-binding of boar sperm acrosin is associated with the N-terminal peptide of the acrosin B-chain (heavy chain).
Infections
Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China.
Infertility
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility.
Infertility
Acrosin antibodies and infertility. I. Detection of antibodies towards proacrosin/acrosin in women consulting for infertility and evaluation of their effects upon the sperm protease activities.
Infertility
Acrosomal proteinase activity of human spermatozoa and relation of results to semen quality.
Infertility
Adenosine 5 triphosphate (ATP) content and acrosin activity in polyzoospermic subjects.
Infertility
Antisperm antibody binding to human acrosin: a study of patients with unexplained infertility.
Infertility
Evidence of proacrosin molecule abnormality as a possible cause of low acrosin activity and unexplained failure of fertilization in vitro.
Infertility
Gelatin-substrate film technique for detection of acrosin in single mammalian sperm.
Infertility
Inhibition of hamster sperm acrosomal enzyme by gossypol is closely associated with the decrease in fertilization capacity.
Infertility
Is spermatozoan acrosin a predictor of fertilization and embryo quality in the human?
Infertility
Long-term contraceptive efficacy of vaccine of ovine follicle-stimulating hormone in male bonnet monkeys (Macaca radiata).
Infertility
Low acrosin activity in a subgroup of men with idiopathic infertility dose not correlate with sperm density, percent motility, curvilinear velocity, or linearity.
Infertility
Proacrosin-deficient mice and zona pellucida modifications in an experimental model of multifactorial infertility.
Infertility
The Change of Semen Superoxide Dismutase and Acrosin Activity in the Sterility of Male Patients with Positive Antisperm Antibody.
Infertility
[Value of sperm acrosin activity detection in selecting the method of assisted reproduction for patients with unexplained infertility].
Infertility, Male
Acrosin activity as a potential marker for sperm membrane characteristics in unexplained male infertility.
Infertility, Male
Acrosin activity in spermatozoa from sterile t6/tw32 and fertile control mice.
Infertility, Male
Gelatin-substrate film technique for detection of acrosin in single mammalian sperm.
Infertility, Male
The Change of Semen Superoxide Dismutase and Acrosin Activity in the Sterility of Male Patients with Positive Antisperm Antibody.
Infertility, Male
[L-carnitine improves sperm acrosin activity in male infertility patients].
Neoplasms
Production, purification, and in vivo evaluation of a novel multiepitope peptide vaccine consisted of immunodominant epitopes of SYCP1 and ACRBP antigens as a prophylactic melanoma vaccine.
Neoplasms
Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation.
Neoplasms
[Effects of interferon-gamma and tumor necrosis factor-alpha on the fertilizing capacity of humam sperm and their mechanisms]
Oligospermia
Acrosin activity of human spermatozoa by means of a simple gelatinolytic technique: a method useful for IVF.
Oligospermia
Determination of active, non-zymogen acrosin, proacrosin and total acrosin in different andrological patients.
Polycystic Kidney Diseases
Characterization of sperm surface protein patterns of ejaculated and capacitated boar sperm, with the detection of ZP binding candidates.
Spinal Cord Injuries
Hyaluronic acid binding and acrosin activity are decreased in sperm from men with spinal cord injury.
Teratozoospermia
Evidence for effects of testis and epididymis expressed genes on sperm quality and boar fertility traits.
Varicocele
"Human sperm physiology: estrogen receptor alpha (ER?) and estrogen receptor beta (ER?) influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male infertility."
Varicocele
The effect of smoking and varicocele on human sperm acrosin activity and acrosome reaction.
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