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Disease on EC 3.4.19.12 - ubiquitinyl hydrolase 1

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Finding effective biomarkers for pediatric traumatic brain injury.
Immunocytochemical identification of T-cells in HIV-1 encephalitis: implications for pathogenesis of CNS disease.
Acute Lung Injury
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Stabilization of the histone acetyltransferase Tip60 by deubiquitinating enzyme USP7 stimulates the release of pro-inflammatory mediators in acute lung injury.
UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo.
Adenocarcinoma
Context-dependent function of the deubiquitinating enzyme USP9X in pancreatic ductal adenocarcinoma.
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.
Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A.
Localization of nerve fibers in colonic polyps, adenomas, and adenocarcinomas by immunocytochemical staining for PGP 9.5.
MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer.
Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma.
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors.
The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma.
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via ?-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
USP2a alters chemotherapeutic response by modulating redox.
[Corrigendum] USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via ??catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
Adenocarcinoma of Lung
Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis.
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of ?-Catenin.
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Targeting USP22 Suppresses Tumorigenicity and Enhances Cisplatin Sensitivity Through ALDH1A3 Downregulation in Cancer-Initiating Cells from Lung Adenocarcinoma.
Targeting USP22 with miR?30?5p to inhibit the hypoxia?induced expression of PD?L1 in lung adenocarcinoma cells.
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-? signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating ?H2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis.
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.
USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.
[Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157]
Adenoma
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Innervation of human adrenal gland and adrenal cortical lesions.
Localization of nerve fibers in colonic polyps, adenomas, and adenocarcinomas by immunocytochemical staining for PGP 9.5.
Molecular Characteristics of Large Parathyroid Adenomas.
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
Peptide-containing nerve fibres in normal human parathyroid glands and in human parathyroid adenomas.
Adenoma, Oxyphilic
Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
Adenoma, Pleomorphic
Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors.
Adenomyosis
Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis.
Neurotrophin expression is not affected in uteri of women with adenomyosis.
[Distribution of nerve fibers in endometrium and its clinical significance in adenomyosis]
Alzheimer Disease
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1.
Chronic Cocaine Use Causes Changes in the Striatal Proteome Depending on the Endogenous Expression of Pleiotrophin.
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening.
Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease.
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease.
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease.
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases.
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Proteomic analysis of brain proteins in the gracile axonal dystrophy (gad) mouse, a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1, reveals oxidation of key proteins.
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.
The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease.
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein.
Amyloidosis
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Amyotrophic Lateral Sclerosis
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.
Proteomics in cerebrospinal fluid and spinal cord suggests UCHL1, MAP2 and GPNMB as biomarkers and underpins importance of transcriptional pathways in amyotrophic lateral sclerosis.
UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis.
Anthrax
Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
Aortic Aneurysm
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Appendicitis
Changes of protein gene product 9.5 (PGP 9.5) immunoreactive nerves in inflamed appendix.
Concentration of UHCL1 in the Serum of Children with Acute Appendicitis, Before and After Surgery, and Its Correlation with CRP and Prealbumin.
Immunoproteasome in the of children with acute appendicitis, and its correlation with proteasome and UCHL1 measured by SPR imaging biosensors.
Arteritis
Coronavirus interactions with the cellular autophagy machinery.
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.
Asthenozoospermia
Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization.
Asthma
Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma.
Astrocytoma
Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.
Ataxia
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
Application of protein knockdown strategy targeting ?-sheet structure to multiple disease-associated polyglutamine proteins.
Ataxin-3 and its e3 partners: implications for machado-joseph disease.
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Casein kinase 2 interacts with and phosphorylates ataxin-3.
Clinical and molecular events in patients with Machado-Joseph disease under lamotrigine therapy.
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3.
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool.
Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.
PolyQ-expanded ataxin-3 protein levels in peripheral blood mononuclear cells correlate with clinical parameters in SCA3: a pilot study.
Prenatal diagnosis of Machado-Joseph disease/Spinocerebellar Ataxia Type 3 in Taiwan: early detection of expanded ataxin-3.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Structural and functional alterations in the androgen receptor in spinal bulbar muscular atrophy.
Sulfatide accumulation in the dystrophic terminals of gracile axonal dystrophy mice: lipid analysis using matrix-assisted laser desorption/ionization imaging mass spectrometry.
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).
The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.
The double dealing of cyclin D1.
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability.
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Ubiquitin homeostasis is critical for synaptic development and function.
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila eyes.
Atherosclerosis
Cezanne is a critical regulator of pathological arterial remodelling by targeting ?-catenin signalling.
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells.
Atrial Fibrillation
Inhibition of UCHL1 by LDN-57444 attenuates Ang II-Induced atrial fibrillation in mice.
Autoimmune Diseases
A20 functions as a negative regulator in macrophage for DSS-induced colitis.
USP19 Suppresses Th17-Driven Pathogenesis in Autoimmunity.
Blindness
Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis.
Bone Marrow Diseases
Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction.
Bone Resorption
Effect of experimental tooth movement on nerve fibres immunoreactive to calcitonin gene-related peptide, protein gene product 9.5, and blood vessel density and distribution in rats.
Brain Concussion
Accuracy of a rapid glial fibrillary acidic protein/ubiquitin carboxyl-terminal hydrolase L1 test for the prediction of intracranial injuries on head computed tomography after mild traumatic brain injury.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
Neuronal Biomarker Ubiquitin C-Terminal Hydrolase (UCH-L1) Detects Traumatic Intracranial Lesions on CT in Children and Youth with Mild Traumatic Brain Injury.
Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention.
Study protocol for investigating the performance of an automated blood test measuring GFAP and UCH-L1 in a prospective observational cohort of patients with mild traumatic brain injury: European BRAINI study.
Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.
Utility Of Serum Biomarkers In The Diagnosis and Stratification Of Mild Traumatic Brain Injury.
Brain Diseases
Placental clearance/synthesis of neurobiomarkers GFAP and UCH-L1 in healthy term neonates and those with moderate-severe neonatal encephalopathy.
Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Brain Injuries
Assessing a Blast-Related Biomarker in an Operational Community: Glial Fibrillary Acidic Protein in Experienced Breachers.
BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma.
Biomarkers May Predict Unfavorable Neurological Outcome after Mild Traumatic Brain Injury.
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury.
Damaged: Elevated GFAP and UCH-L1 as the Black Flag of Brain Injury.
Development of prognostic models for patients with traumatic brain injury: a systematic review.
Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury.
Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
In vivo transduction of neurons with TAT-UCH-L1 protects brain against controlled cortical impact injury.
Modeling the Kinetics of Serum Glial Fibrillary Acidic Protein, Ubiquitin Carboxyl-Terminal Hydrolase-L1, and S100B Concentrations in Patients with Traumatic Brain Injury.
Morphologic and Biochemical Characterization of Brain Injury in a Model of Controlled Blast Overpressure Exposure.
Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest.
Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits.
Ubiquitin C-Terminal Hydrolase 1 and Phosphorylated Axonal Neurofilament Heavy Chain in Infants Undergoing Cardiac Surgery: Preliminary Assessment as Potential Biomarkers of Brain Injury.
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Utility Of Serum Biomarkers In The Diagnosis and Stratification Of Mild Traumatic Brain Injury.
Brain Injuries, Traumatic
176?The Levels of GFAP and UCH-L1 During the First Week After a Traumatic Brain Injury-Correlations With Clinical and Imaging Findings and Outcome.
A Panel of Neuron-Enriched Proteins as Markers for Traumatic Brain Injury in Humans.
A Pilot Study of Novel biomarkers in neonates with Hypoxic-Ischemic Encephalopathy.
Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury.
Acute biomarkers of traumatic brain injury: Relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and glial fibrillary acidic protein (GFAP).
Acute Temporal Profiles of serum levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology Following Traumatic Brain Injury in Rats.
Biokinetic Analysis of Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Severe Traumatic Brain Injury Patient Biofluids.
Biomarkers Associated with the Outcome of Traumatic Brain Injury Patients.
Blood Biomarkers Relate to Cognitive Performance Years after Traumatic Brain Injury in Service Members and Veterans.
Cerebral Expression of Glial Fibrillary Acidic Protein, Ubiquitin Carboxy-Terminal Hydrolase-L1, and Matrix Metalloproteinase 9 After Traumatic Brain Injury and Secondary Brain Insults in Rats.
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Characterization of Cerebrospinal Fluid Ubiquitin C-Terminal Hydrolase L1 as a Biomarker of Human Acute Traumatic Spinal Cord Injury.
Clinical Utility of Serum Levels of Ubiquitin C-Terminal Hydrolase as a Biomarker for Severe Traumatic Brain Injury.
Comparison of GFAP and UCH-L1 Measurements from Two Prototype Assays: The Abbott i-STAT and ARCHITECT Assays.
Comparison of the performances of copeptin and multiple biomarkers in long-term prognosis of severe traumatic brain injury.
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
Elevated Serum Ubiquitin Carboxy-terminal Hydrolase L1 is Associated with Abnormal Blood Brain Barrier Function after Traumatic Brain Injury.
Erythropoietin Does Not Alter Serum Profiles of Neuronal and Axonal Biomarkers After Traumatic Brain Injury: Findings From the Australian EPO-TBI Clinical Trial.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study.
Modeling the Kinetics of Serum Glial Fibrillary Acidic Protein, Ubiquitin Carboxyl-Terminal Hydrolase-L1, and S100B Concentrations in Patients with Traumatic Brain Injury.
Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain Injury.
Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant Traumatic Brain Injury Biomarkers.
Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury.
Progesterone Treatment Does Not Decrease Serum Levels of Biomarkers of Glial and Neuronal Cell Injury in Moderate and Severe Traumatic Brain Injury Subjects: A Secondary Analysis of the Progesterone for Traumatic Brain Injury, Experimental Clinical Treatment (ProTECT) III Trial.
Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury.
Routine Blood Tests for Severe Traumatic Brain Injury: Can They Predict Outcomes?
Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review.
Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.
Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention.
Serum ubiquitin C-terminal hydrolase L1 as a biomarker for traumatic brain injury: a systematic review and meta-analysis.
Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.
Temporal response profiles of serum ubiquitin C-terminal hydrolase-L1 and the 145-kDa alpha II-spectrin breakdown product after severe traumatic brain injury in children.
The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings.
Thorough overview of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein as tandem biomarkers recently cleared by US Food and Drug Administration for the evaluation of intracranial injuries among patients with traumatic brain injury.
Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury.
Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI.
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury*
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in Prediction of Computed Tomography Findings in Traumatic Brain Injury; a Meta-Analysis.
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma.
Valproic Acid Treatment Decreases Serum GFAP and UCH-L1 Level in Swine Subjected to Traumatic Brain Injury.
Variation in Candidate Traumatic Brain Injury Biomarker Genes Are Associated with Gross Neurological Outcomes after Severe Traumatic Brain Injury.
Brain Ischemia
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Brain Neoplasms
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.
Breast Neoplasms
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1.
Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5).
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression.
COPS5 amplification and overexpression confers tamoxifen-resistance in ER?-positive breast cancer by degradation of NCoR.
Correlation of apoptosis with the distribution and composition of lymphocytic infiltrate in human breast carcinomas.
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF?-Induced Breast Cancer Metastasis.
Deubiquitinase ubiquitin-specific protease 9X regulates the stability and function of E3 ubiquitin ligase ring finger protein 115 in breast cancer cells.
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1.
Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells.
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance.
Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer.
Erratum: The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis.
Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer.
Interaction between CD147 and P-glycoprotein and their regulation by ubiquitination in breast cancer cells.
Lentivirus-mediated inhibition of USP39 suppresses the growth of breast cancer cells in vitro.
MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.
OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance.
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells.
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway.
Prognostic relevance of ubiquitin C-terminal hydrolase L1 (UCH-L1) mRNA and protein expression in breast cancer patients.
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.
The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis.
The deubiquitinating enzyme USP1 modulates ER? and modulates breast cancer progression.
The deubiquitinating enzyme USP15 stabilizes ER? and promotes breast cancer progression.
The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors.
The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.
UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer.
UCH-L1-mediated Down-regulation of Estrogen Receptor ? Contributes to Insensitivity to Endocrine Therapy for Breast Cancer.
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.
Up-regulated proteins in the fluid bathing the tumour cell microenvironment as potential serological markers for early detection of cancer of the breast.
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer.
USP22 positively modulates ER? action via its deubiquitinase activity in breast cancer.
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
[Influence of UCHL5 on proliferation and apoptosis of SW527 breast cancer cells].
Bronchiectasis
[Changes in neuroendocrine cells and immunocompetent cells in bronchiectasis]
Bronchitis
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Coronavirus interactions with the cellular autophagy machinery.
Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus.
The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity.
Burkitt Lymphoma
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
Bursitis
Enhanced expression of neuronal proteins in idiopathic frozen shoulder.
CADASIL
Plasma neurofilament light chain and glial fibrillary acidic protein predict stroke in CADASIL.
Carcinogenesis
'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state.
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.
Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.
Friend or Foe: UCHL3 Mediated Carcinogenesis and Current Approaches in Small Molecule Inhibitors' Development.
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-?B signaling.
MiR-101 targets USP22 to inhibit the tumorigenesis of papillary thyroid carcinoma.
miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
Naturally Occurring Isothiocyanates Exert Anticancer Effects by Inhibiting Deubiquitinating Enzymes.
Novel protein and immune response markers of human serous tubal intraepithelial carcinoma of the ovary.
Nuclear GSK3? promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.
Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma.
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy.
Proteasomal deubiquitinase UCH37 inhibits degradation of ?-catenin and promotes cell proliferation and motility.
Proteomics of DF-1 cells infected with avian leukosis virus subgroup J.
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-? signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
The potential role of TNFAIP3 in malignant transformation of gastric carcinoma.
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial-mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells.
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Ubiquitin-specific protease 22 promotes the proliferation, migration and invasion of glioma cells.
Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis.
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC driven lymphomagenesis in mice.
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-?B pathway.
USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability.
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
Usp22 and its evolving role in systemic carcinogenesis.
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.
USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization.
USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.
USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via ?-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma.
USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1.
USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers.
USP4 promotes invasion of breast cancer cells via Relaxin/TGF-?1/Smad2/MMP-9 signal.
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
USP7 manipulation by viral proteins.
[Research advances on ubiquitin C-terminal hydrolase in oncogenesis and progression].
Carcinoid Tumor
Carcinoid tumour of stomach and primary hyperparathyroidism: a new association.
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Carcinoma
'Neuroendocrine' differentiation in primary neoplasms of the liver.
?-Chymotrypsin regulates free fatty acids and UCHL-1 to ameliorate N-methyl nitrosourea induced mammary gland carcinoma in albino wistar rats.
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.
An emerging model for BAP1's role in regulating cell cycle progression.
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44.
Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico.
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Cytoplasmic expression of BAP1 as an independent prognostic biomarker for patients with gliomas.
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma.
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.
Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance.
Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones.
Early phase TGF? receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses.
Endocrine differentiation of extra-pulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP 9.5, neuron-specific enolase and the C-flanking peptide of human pro-bombesin.
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Increased expression of USP22 is associated with disease progression and patient prognosis of salivary duct carcinoma.
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Innervation of human adrenal gland and adrenal cortical lesions.
Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
MicroRNA?542?3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.
Molecular Characteristics of Large Parathyroid Adenomas.
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.
Neuroendocrine differentiation and nerves in human adrenal cortex and cortical lesions.
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
p38 mitogen-activated protein kinase inhibits USP22 transcription in HeLa cells.
Parathyroid Carcinoma Encountered After Minimally Invasive Focused Parathyroidectomy may not Require Further Radical Surgery.
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.
Proliferation of alpha-smooth muscle actin-containing stromal cells (myofibroblasts) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus.
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours.
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma.
The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors.
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Tumoral infiltrate after local treatment with interferon in squamous cell carcinoma.
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
USP19 and RPL23 as Candidate Prognostic Markers for Advanced-Stage High-Grade Serous Ovarian Carcinoma.
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
USP22 Is Useful as a Novel Molecular Marker for Predicting Disease Progression and Patient Prognosis of Oral Squamous Cell Carcinoma.
USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma.
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin.
[Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157]
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
[Influence of UCHL5 on proliferation and apoptosis of SW527 breast cancer cells].
Carcinoma in Situ
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Proliferation of alpha-smooth muscle actin-containing stromal cells (myofibroblasts) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus.
Carcinoma, Adenoid Cystic
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Carcinoma, Basal Cell
BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Carcinoma, Ductal
Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance.
PGP9.5 as a prognostic factor in pancreatic cancer.
Carcinoma, Embryonal
Statistical considerations in the methodology of quantifying immunocompetent cells in tumors.
Carcinoma, Hepatocellular
'Neuroendocrine' differentiation in primary neoplasms of the liver.
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma.
Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein.
Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion.
Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
High USP22 expression indicates poor prognosis in hepatocellular carcinoma.
Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation.
Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest.
Reactive Oxygen Species-Mediated Cezanne Inactivation by Oxidation of its Catalytic Cysteine Residue in Hepatocellular Carcinoma.
Self-Activated Cascade-Responsive Sorafenib and USP22 shRNA Co-Delivery System for Synergetic Hepatocellular Carcinoma Therapy.
The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.
The relationship between the expression of USP22, BMI1, and EZH2 in hepatocellular carcinoma and their impacts on prognosis.
Ubiquitin C-terminal Hydrolase 37, a novel predictor for hepatocellular carcinoma recurrence, promotes cell migration and invasion via interacting and deubiquitinating PRP19.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.
USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway.
USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1?/USP22 positive feedback loop upon TP53 inactivation.
Carcinoma, Large Cell
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.
Carcinoma, Lobular
Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes.
Carcinoma, Medullary
PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma.
Carcinoma, Neuroendocrine
Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.
Carcinoma, Non-Small-Cell Lung
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
MicroRNA-103a Curtails the Stemness of Non-Small Cell Lung Cancer Cells by Binding OTUB1 via the Hippo Signaling Pathway.
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth.
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair.
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
[Establishment and characterization of A549 tumor monoclonal cell line with UCHL1 gene deletion].
Carcinoma, Ovarian Epithelial
High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Carcinoma, Renal Cell
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico.
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Computational analysis of the mutations in BAP1, PBRM1 and SETD2 genes reveals the impaired molecular processes in renal cell carcinoma.
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones.
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.
Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.
Loss of PBRM1 and BAP1 expression is less common in non-clear cell renal cell carcinoma than in clear cell renal cell carcinoma.
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma.
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin.
Carcinoma, Small Cell
Endocrine differentiation of extra-pulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP 9.5, neuron-specific enolase and the C-flanking peptide of human pro-bombesin.
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Carcinoma, Squamous Cell
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Deubiquitylatinase inhibitor b-AP15 induces c-Myc-Noxa-mediated apoptosis in esophageal squamous cell carcinoma.
Diagnostic value of multiple tumor-associated autoantibodies in lung cancer.
Immunohistochemical markers of small cell carcinoma and related neuroendocrine tumours of the lung.
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Tumoral infiltrate after local treatment with interferon in squamous cell carcinoma.
Cardiomegaly
De-ubiquitination of p300 by USP12 Critically Enhances METTL3 Expression and Ang II-induced cardiac hypertrophy.
The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor.
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Ubiquitin-Specific Protease 4 Is an Endogenous Negative Regulator of Pathological Cardiac Hypertrophy.
Cardiomyopathies
Evaluation of cardiac adrenergic neuronal damage in rats with doxorubicin-induced cardiomyopathy using iodine-131 MIBG autoradiography and PGP 9.5 immunohistochemistry.
Cardiomyopathy, Hypertrophic
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion.
Cataract
Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) S18Y Polymorphism In Patients With Cataracts.
Cerebellar Ataxia
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
Cerebellar Diseases
Polyglutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation.
Cerebral Hemorrhage
Diagnostic Accuracy of Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-Terminal Hydrolase-L1 Serum Concentrations for Differentiating Acute Intracerebral Hemorrhage from Ischemic Stroke.
Melatonin Suppresses Microglial Necroptosis by Regulating Deubiquitinating Enzyme A20 After Intracerebral Hemorrhage.
OTUB1 attenuates neuronal apoptosis after intracerebral hemorrhage.
USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Cerebral Infarction
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Chagas Disease
GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection.
Chediak-Higashi Syndrome
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Chickenpox
The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.
Cholangiocarcinoma
Aberrant methylation of HTATIP2 and UCHL1 as a predictive biomarker for cholangiocarcinoma.
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.
Chondrosarcoma
Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation.
Chordoma
Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.
Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.
Genome-wide DNA methylation profiling of recurrent and non-recurrent chordomas.
Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma.
Chorea
Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
Chorioamnionitis
Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses.
Chronic Traumatic Encephalopathy
The anatomy of concussion and chronic traumatic encephalopathy: A comprehensive review.
Cleft Lip
Characteristics of Neuropeptide-Containing Innervation, Tissue Remodeling, Growth, and Vascularity in Noses of Patients With Cleft Lip and Palate.
Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-?3 Signaling Pathway.
Cleft Palate
Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-?3 Signaling Pathway.
Colitis
A20 functions as a negative regulator in macrophage for DSS-induced colitis.
Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway.
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.
USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer.
Colonic Neoplasms
BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
Colon cancer bears overexpression of OTUB1.
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Endogenous hydrogen sulfide regulates xCT stability through persulfidation of OTUB1 at cysteine 91 in colon cancer cells.
Establishment of a high-throughput detection system for DNA demethylating agents.
Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer.
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
PGP9.5 methylation as a marker for metastatic colorectal cancer.
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage.
Ubiquitin-specific peptidase 22 inhibits colon cancer cell invasion by suppressing the signal transducer and activator of transcription 3/matrix metalloproteinase 9 pathway.
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.
Colorectal Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Ataxin-3 expression correlates with the clinicopathologic stage and prognosis of colorectal cancer.
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1.
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
ERR? Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration.
Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.
Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas.
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth.
Long Non-Coding RNA SNHG16 Activates USP22 Expression to Promote Colorectal Cancer Progression by Sponging miR-132-3p.
miR-542-3p inhibits colorectal cancer cell proliferation, migration and invasion by targeting OTUB1.
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.
PGP9.5 as a marker for invasive colorectal cancer.
PGP9.5 methylation as a marker for metastatic colorectal cancer.
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
Silencing of the UCHL1 gene in human colorectal and ovarian cancers.
Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer.
TGF-?1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA.
UCHL1 acts as a colorectal cancer oncogene via activation of the ?-catenin/TCF pathway through its deubiquitinating activity.
UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.
UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.
USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway.
USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
USP22 Suppresses SPARC Expression in Acute Colitis and Inflammation-Associated Colorectal Cancer.
USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/?-catenin pathway via Axin1 deubiquitination.
Coma
Biomarkers May Predict Unfavorable Neurological Outcome after Mild Traumatic Brain Injury.
Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 as Outcome Predictors in Traumatic Brain Injury.
Glial Neuronal Ratio (GNR): a Novel Index for Differentiating Injury Type in Patients with Severe Traumatic Brain Injury.
Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study.
Serum concentrations of ubiquitin C-terminal hydrolase-L1 and ?II-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI.
Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.
Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients.
The Levels of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 During the First Week After a Traumatic Brain Injury: Correlations With Clinical and Imaging Findings.
Common Variable Immunodeficiency
Abnormal CD45R expression in patients with common variable immunodeficiency and X-linked agammaglobulinaemia.
Communicable Diseases
Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach.
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
Coronavirus Infections
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.
Coronavirus interactions with the cellular autophagy machinery.
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches.
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach.
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease.
Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.
Structurally guided removal of deISGylase biochemical activity from papain-Like protease originating from the Middle East Respiratory Syndrome Virus.
The emerging SARS-CoV-2 papain-like protease: Its relationship with recent coronavirus epidemics.
Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus.
COVID-19
"Identification of Nafamostat and VR23 as COVID-19 drug candidates by targeting 3CLpro and PLpro."
3CLpro and PLpro affinity, a docking study to fight COVID19 based on 900 compounds from PubChem and literature. Are there new drugs to be found?
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19.
Chemical-informatics approach to COVID-19 drug discovery: Monte Carlo based QSAR, virtual screening and molecular docking study of some in-house molecules as papain-like protease (PLpro) inhibitors.
Computational Evidences of Phytochemical Mediated Disruption of PLpro Driven Replication of SARS-CoV-2: A Therapeutic Approach Against COVID-19.
Coronavirus interactions with the cellular autophagy machinery.
Discovery of small molecule PLpro inhibitor against COVID-19 using structure-based virtual screening, molecular dynamics simulation, and molecular mechanics/Generalized Born surface area (MM/GBSA) calculation.
Discovery of Some Antiviral Natural products to fight against Novel Corona Virus (SARS-CoV-2) using Insilico approach.
Drug repurposing using computational methods to identify therapeutic options for COVID-19.
Dual targeting of 3CLpro and PLpro of SARS-CoV-2: A novel structure-based design approach to treat COVID-19.
Existing antiviral options against SARS-CoV-2 replication in COVID-19 patients.
Identification of novel human USP2 inhibitor and its putative role in treatment of COVID-19 by inhibiting SARS-CoV-2 papain-like (PLpro) protease.
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach.
Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19.
ISG15-dependent Activation of the RNA Sensor MDA5 and its Antagonism by the SARS-CoV-2 papain-like protease.
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity.
Losartan Inhibits SARS-CoV-2 Replication in Vitro.
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Molecular docking of potential SARS-CoV-2 papain-like protease inhibitors.
Molecular docking studies, molecular dynamics and ADME/tox reveal therapeutic potentials of STOCK1N-69160 against papain-like protease of SARS-CoV-2.
Natural Products with tandem Anti-inflammatory, Immunomodulatory and Anti-SARS-CoV/2 effects: A Drug Discovery Perspective against SARS-CoV-2.
Potential COVID-19 papain-like protease PLpro inhibitors: repurposing FDA-approved drugs.
Potential Natural Products Against Respiratory Viruses: A Perspective to Develop Anti-COVID-19 Medicines.
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors.
Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019.
Repurposing Known Drugs as Covalent and Non-covalent Inhibitors of the SARS-CoV-2 Papain-Like Protease.
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like protease.
Spatial and temporal roles of SARS-CoV PLpro -A snapshot.
Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study.
Targeting SARS-CoV-2 viral proteases as a therapeutic strategy to treat COVID-19.
The Promising Enzymes for Inhibitors Development against COVID-19.
Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases.
Virtual screening of phytoconstituents from miracle herb nigella sativa targeting nucleocapsid protein and papain-like protease of SARS-CoV-2 for COVID-19 treatment.
Craniocerebral Trauma
BDNF and IL-8, But Not UCHL-1 and IL-11, Are Markers of Brain Injury in Children Caused by Mild Head Trauma.
Biofluid biomarkers of traumatic brain injury.
Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury.
Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study.
Neuronal Biomarker Ubiquitin C-Terminal Hydrolase (UCH-L1) Detects Traumatic Intracranial Lesions on CT in Children and Youth with Mild Traumatic Brain Injury.
Significance of ubiquitin carboxy-terminal hydrolase L1 elevations in athletes after sub-concussive head hits.
Utility Of Serum Biomarkers In The Diagnosis and Stratification Of Mild Traumatic Brain Injury.
Cryptorchidism
Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation.
Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism.
Two closely related ubiquitin C-terminal hydrolase isozymes function as reciprocal modulators of germ cell apoptosis in cryptorchid testis.
Uchl1 and its associated proteins were involved in spermatocyte apoptosis in mouse experimental cryptorchidism.
Cystic Fibrosis
The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates.
Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation.
Cystitis
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome.
Cysts
Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Innervation of ectopic endometrium in a rat model of endometriosis.
Deglutition Disorders
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Delirium
Association of neuronal repair biomarkers with delirium among survivors of critical illness.
Association of Plasma Neurofilament Light with Postoperative Delirium.
Intraoperative Oxidative Damage and Delirium after Cardiac Surgery.
Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019.
Dementia
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
Mutation Analysis of the Genes Associated with Parkinson's Disease in a Finnish Cohort of Early-Onset Dementia.
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies.
Demyelinating Diseases
OTUB1 inhibits CNS autoimmunity by preventing IFN-?-induced hyperactivation of astrocytes.
Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.
Dengue
A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication.
Dermatitis, Atopic
Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis.
PGP 9.5 distribution patterns in biopsies from early lesions of atopic dermatitis.
[Role of the skin expression of neuropeptides, neurotrophins and their receptors in the pathogenesis of dermatoses].
Dermatofibrosarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Diabetes Mellitus
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ?-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
Diabetes Mellitus, Type 1
Adrenal medullitis in type I diabetes.
Otubain 2 is a novel promoter of beta cell survival as revealed by siRNA high-throughput screens of human pancreatic islets.
Diabetes Mellitus, Type 2
BETA-CELL DYSFUNCTIONAL ERAD/UBIQUITIN/PROTEASOME SYSTEM IN TYPE 2 DIABETES MEDIATED BY IAPP-INDUCED UCH-L1 DEFICIENCY.
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Patterns of cutaneous nerve fibre loss and regeneration in type 2 diabetes with painful and painless polyneuropathy.
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ?-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
Diabetic Nephropathies
AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-?1 expression in male rat glomerular mesangial cells.
BMSCs-derived exosomal microRNA-let-7a plays a protective role in diabetic nephropathy via inhibition of USP22 expression.
Diabetic Neuropathies
Epidermal transient receptor potential vanilloid 1 in idiopathic small nerve fibre disease, diabetic neuropathy and healthy human subjects.
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy.
Diastema
Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers.
Diverticular Diseases
Post inflammatory damage to the enteric nervous system in diverticular disease and its relationship to symptoms.
DNA Virus Infections
USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA.
Down Syndrome
A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury.
Placenta proteome analysis from Down syndrome pregnancies for biomarker discovery.
Selective upregulation of the ubiquitin-proteasome proteolytic pathway proteins, proteasome zeta chain and isopeptidase T in fetal Down syndrome.
Dysgerminoma
Expression of Protein Gene Product 9.5 and Sal-like Protein 4 in Canine Seminomas.
Dyslipidemias
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Dystonia
Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease.
Encephalitis
Immunocytochemical identification of T-cells in HIV-1 encephalitis: implications for pathogenesis of CNS disease.
The deubiquitinase OTUB1 augments NF-?B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Encephalitis, Tick-Borne
High-Throughput Fluorescent Assay for Inhibitor Screening of Proteases from RNA Viruses.
Endometrial Neoplasms
High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.
OTU-domain containing ubiquitin aldehyde binding protein 1 (OTUB1) deubiquitinates estrogen receptor - alpha (ERalpha ) and affects ERalpha transcriptional activity.
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression.
Endometriosis
Calcium-binding protein expression in peritoneal endometriosis-associated nerve fibres.
Combination of the non-invasive tests for the diagnosis of endometriosis.
Decreased nerve fibers in the oviduct isthmus of women with endometriosis.
Density of small diameter sensory nerve fibres in endometrium: a semi-invasive diagnostic test for minimal to mild endometriosis.
Detection of the pan neuronal marker PGP9.5 by immuno-histochemistry and quantitative PCR in eutopic endometrium from women with and without endometriosis.
Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis.
Endometrial biopsy and density of nerve fibers in eutopic endometrium. Looking for easier ways to diagnose endometriosis.
Identification of biomarkers for endometriosis in eutopic endometrial cells from patients with endometriosis using a proteomics approach.
The importance of endometrial nerve fibers and macrophage cell count in the diagnosis of endometriosis.
Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
Ependymoma
Paraganglioma of the cauda equina. A case report and review of the literature.
Epilepsy
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.
Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy.
The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.
Epstein-Barr Virus Infections
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.
Esophageal Neoplasms
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
MicroRNA?542?3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Targeting deubiquitinating enzyme USP26 by microRNA-203 regulates Snail1's pro-metastatic functions in esophageal cancer.
USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.
[The role of hypermethylation in promoter region of ubiquitin carboxyl-terminal hydrolase L1 in human esophageal cancer].
Esophageal Squamous Cell Carcinoma
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
MicroRNA?542?3p represses OTUB1 expression to inhibit migration and invasion of esophageal cancer cells.
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
Proliferation of alpha-smooth muscle actin-containing stromal cells (myofibroblasts) in the lamina propria subjacent to intraepithelial carcinoma of the esophagus.
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
USP22 nuclear expression is significantly associated with progression and unfavorable clinical outcome in human esophageal squamous cell carcinoma.
Exanthema
Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy.
Fanconi Anemia
A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.
Inactivation of Uaf1 causes Defective Homologous Recombination and Early Embryonic Lethality in Mice.
Interaction of the Human Papillomavirus E1 Helicase with UAF1-USP1 Promotes Unidirectional Theta Replication of Viral Genomes.
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
The USP1/UAF1 complex promotes double-strand break repair through homologous recombination.
UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
Fetal Growth Retardation
USP22 regulates the formation and function of placental vasculature during the development of fetal growth restriction.
Fibroadenoma
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors.
Fibrosarcoma
Multiple Polymerase Chain Reaction Markers for the Differentiation of Canine Cutaneous Peripheral Nerve Sheath Tumours versus Canine Fibrosarcomas.
Gallbladder Neoplasms
PGP9.5 methylation as a marker for metastatic colorectal cancer.
Gallstones
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Ganglioneuroblastoma
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
Ganglioneuroma
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
Gastrinoma
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Gastritis, Atrophic
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Gastroenteritis
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Papain-like protease 1 from transmissible gastroenteritis virus: crystal structure and enzymatic activity toward viral and cellular substrates.
Transmissible Gastroenteritis Virus Papain-Like Protease 1 Antagonizes Production of Interferon-
Gastrointestinal Neoplasms
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Gastrointestinal Stromal Tumors
The significance of PGP 9.5 in tumours--an immunohistochemical study of gastrointestinal stromal tumours.
Gaucher Disease
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Genetic Diseases, Inborn
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
Giant Cell Tumors
Silencing of the UCHL1 gene in giant cell tumors of bone.
Gingival Diseases
Expression of immunoreactivities to 75 kDa nerve growth factor receptor, trk gene product and phosphotyrosine in granular cell tumors.
Gingivitis
Comparison of NK-cell (Leu-7+ and Leu-11b+) populations in clinically healthy gingiva, chronic gingivitis and chronic adult periodontitis.
Glioblastoma
Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity.
Nuclear GSK3? promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
Synthesis, characterization, and optimization for in vivo delivery of a nonselective isopeptidase inhibitor as new antineoplastic agent.
Glioma
'Neuron-specific' protein gene product 9.5 (PGP 9.5) is also expressed in glioma cell lines and its expression depends on cellular growth state.
Biochemical and cellular characterization of a cyanopyrrolidine covalent Ubiquitin C-terminal hydrolase L1 inhibitor.
ECT2/PSMD14/PTTG1 axis promotes the proliferation of glioma through stabilizing E2F1.
Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells.
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer.
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.
RNA interference-mediated USP22 gene silencing promotes human brain glioma apoptosis and induces cell cycle arrest.
Silencing of OTUB1 inhibits migration of human glioma cells in vitro.
Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma.
Ubiquitin carboxyl-terminal hydrolase isozyme L5 inhibits human glioma cell migration and invasion via downregulating SNRPF.
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Ubiquitin-specific protease 22 promotes the proliferation, migration and invasion of glioma cells.
Ubiquitin-specific protease 22: a novel molecular biomarker in glioma prognosis and therapeutics.
UCHL1 enhances the malignant development of glioma via targeting GAS2.
Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade.
Glomerulonephritis
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
Detection of UCH-L1 expression by pre-embedding immunoelectron microscopy with colloidal gold labeling in diseased glomeruli.
Macrophages in human immunodeficiency virus-associated kidney diseases.
Neonatal Fc receptor stimulation induces ubiquitin c-terminal hydrolase-1 overexpression in podocytes through activation of p38 mitogen-activated protein kinase.
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level.
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
[Immunohistochemical analysis of protein gene product 9.5, a new marker for parietal epithelial cells of Bowman's capsules, in anti-glomerular basement membrane(GBM) antibody induced glomerulonephritis of WKY rats]
Glomerulonephritis, IGA
An emerging role of deubiquitinating enzyme cylindromatosis (CYLD) in the tubulointerstitial inflammation of IgA nephropathy.
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Glomerulonephritis, Membranous
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
Glomerulosclerosis, Focal Segmental
Macrophages in human immunodeficiency virus-associated kidney diseases.
Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Glucagonoma
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Glucose Intolerance
The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.
Granular Cell Tumor
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Immunohistochemical analysis of equine pulmonary granular cell tumours.
PGP 9.5, a new marker for human neuroendocrine tumours.
Graves Disease
Correlation of microsomal antibodies with the intensity of the intrathyroidal autoimmune process in Graves' disease.
Hearing Loss
Progressive Hearing Loss in Mice Carrying a Mutation in Usp53.
Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss.
Heart Arrest
Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.
Serum GFAP and UCH-L1 for the prediction of neurological outcome in comatose cardiac arrest patients.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Heart Diseases
Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Ubiquitin-specific protease 19 blunts pathological cardiac hypertrophy via inhibition of the TAK1-dependent pathway.
Hematologic Neoplasms
Immunophenotyping of hematopoietic malignancies in paraffin sections.
Hemorrhagic Stroke
Different expression of ubiquitin C-terminal hydrolase-L1 and ?II-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.
Hepatic Encephalopathy
Preferential recruitment of ataxin-3 independent of expanded polyglutamine: an immunohistochemical study on Marinesco bodies.
Hepatitis
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis.
Coronavirus interactions with the cellular autophagy machinery.
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond.
Hepatitis B
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Hepatitis C
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes.
Hepatitis C, Chronic
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes.
Clinical and histopathologic analysis of the relationship between lichen planus and chronic hepatitis C.
Hepatitis E
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Herpes Simplex
Coronavirus interactions with the cellular autophagy machinery.
Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions.
The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.
Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding.
Herpes Zoster
Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
Natural history of cutaneous innervation following herpes zoster.
The density of remaining nerve endings in human skin with and without postherpetic neuralgia after shingles.
The reading frame BPLF1 of Epstein-Barr virus: a homologue of herpes simplex virus protein VP16.
Hidradenitis Suppurativa
Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa.
Hirschsprung Disease
Evaluation of PGP9.5 in the diagnosis of Hirschsprung's disease.
Morphometric evaluation of PGP9.5 and NCAM expressing nerve fibers in colonic muscle of patients with Hirschsprung's disease.
The development of colon innervation in trisomy 16 mice and Hirschsprung's disease.
Histiocytic Sarcoma
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Histiocytoma, Malignant Fibrous
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.
Histiocytosis
Immunohistochemical study on antigenic phenotype of Langerhans cell histiocytosis.
Histiocytosis, Langerhans-Cell
Immunohistochemical study on antigenic phenotype of Langerhans cell histiocytosis.
Hodgkin Disease
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Hodgkin disease with subsequent transformation to CD30 positive non-hodgkin lymphoma in six patients.
Hodgkin-like lymphoma, simulating anaplastic large cell lymphoma in the patient after renal transplantation--unusual case report and literature review.
Immunohistochemical characteristics of Hodgkin and Reed-Sternberg cells in relation to age and clinical outcome.
Lymphocyte predominance Hodgkin's disease--an immunohistochemical study.
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
[The immunological characterization of 63 cases of Hodgkin's disease with a panel of 8 antibodies]
Huntington Disease
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.
Broadening the therapeutic scope for rapamycin treatment.
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington's disease.
Polymorphism of HD and UCHL-1 genes in Huntington's disease.
Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.
The de-ubiquitinating enzyme ataxin-3 does not modulate disease progression in a knock-in mouse model of Huntington disease.
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
The S18Y polymorphism in the UCHL1 gene is a genetic modifier in Huntington's disease.
Hyperalgesia
A pain in the skin. Regenerating nerve sprouts are distinctly associated with ongoing burning pain in patients with diabetes.
The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania major-induced lesions related to nociceptive thresholds.
The reduction of intraepidermal P2X3 nerve fiber density correlates with behavioral hyperalgesia in a rat model of nerve injury-induced pain.
Hyperglycemia
Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets.
Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination.
Sustained ER stress promotes hyperglycemia by increasing glucagon action through the deubiquitinating enzyme USP14.
Hyperlipidemias
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Hyperlipoproteinemia Type I
Lipoprotein lipase deficiency leads to ?-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction.
Hyperphosphatemia
Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary ?-klotho deficiency and perturbed phosphate homeostasis.
Hypersensitivity
Voltage-gated ion channel Na(v)1.7 innervation in patients with idiopathic rectal hypersensitivity and paroxysmal extreme pain disorder (familial rectal pain).
Hypertension
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
Hypertensive Retinopathy
Long-term inhibition of UCHL1 decreases hypertension and retinopathy in spontaneously hypertensive rats.
Hypophosphatemia, Familial
Ubiquitin COOH-terminal hydrolase L1 deletion is associated with urinary ?-klotho deficiency and perturbed phosphate homeostasis.
Hypotension
De novo synthesis of ubiquitin carboxyl-terminal hydrolase isozyme l1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication.
Hypoxia-Ischemia, Brain
Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A Single Center Pilot Study.
Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy.
[Effect of hypothermia therapy on serum GFAP and UCH-L1 levels in neonates with hypoxic-ischemic encephalopathy].
Idiopathic Pulmonary Fibrosis
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
Immune System Diseases
Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.
Infarction, Middle Cerebral Artery
Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1.
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats.
Infections
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
A Scoping Insight on Potential Prophylactics, Vaccines and Therapeutic Weaponry for the Ongoing Novel Coronavirus (COVID-19) Pandemic- A Comprehensive Review.
Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes.
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction.
Epstein-Barr Virus Deubiquitinase Downregulates TRAF6-Mediated NF-?B Signaling during Productive Replication.
GRAIL and Otubain-1 are Related to T Cell Hyporesponsiveness during Trypanosoma cruzi Infection.
Gut-derived cholecystokinin contributes to visceral hypersensitivity via nerve growth factor-dependent neurite outgrowth.
In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2.
Interplay of the ubiquitin proteasome system and the innate immune response is essential for the replication of infectious bronchitis virus.
Iridoviral infection can be reduced by UCHL1-loaded exosomes from the testis of Chinese giant salamanders (Andrias davidianus).
Kaposi's Sarcoma Associated Herpesvirus Infection Induces the Expression of Neuroendocrine Genes in Endothelial Cells.
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Leader protein of encephalomyocarditis virus binds zinc, is phosphorylated during viral infection, and affects the efficiency of genome translation.
Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response.
Murine Cytomegalovirus Deubiquitinase Regulates Viral Chemokine Levels To Control Inflammation and Pathogenesis.
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation.
Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1.
Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures.
Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice.
Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease.
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus.
SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme.
Scavenger receptor A impairs interferon response to HBV infection by limiting TRAF3 ubiquitination through recruiting OTUB1.
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
The deubiquitinase OTUB1 augments NF-?B-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
The deubiquitinating enzyme AMSH1 is required for rhizobial infection and nodule organogenesis in Lotus japonicus.
The Drosophila deubiquitinating enzyme dUSP36 acts in the hemocytes for tolerance to Listeria monocytogenes infections.
The Epstein-Barr virus deubiquitinase BPLF1 targets SQSTM1/p62 to inhibit selective autophagy.
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.
The Epstein-Barr Virus Immunoevasins BCRF1 and BPLF1 Are Expressed by a Mechanism Independent of the Canonical Late Pre-initiation Complex.
The papain-like protease of porcine epidemic diarrhea virus negatively regulates type I interferon pathway by acting as a viral deubiquitinase.
The Translesion Polymerase Pol ? Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases.
Infectious Mononucleosis
The Translesion Polymerase Pol ? Is Required for Efficient Epstein-Barr Virus Infectivity and Is Regulated by the Viral Deubiquitinating Enzyme BPLF1.
Infertility
Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen.
Infertility, Male
Mice Lacking the USP2 Deubiquitinating Enzyme Have Severe Male Subfertility Associated with Defects in Fertilization and Sperm Motility.
Ubiquitin Carboxy-Terminal HydrolaseL3 Correlates with Human Sperm Count, Motility and Fertilization.
Inflammatory Bowel Diseases
The deubiquitinating enzyme OTUD5 sustains inflammatory cytokine response in inflammatory bowel disease.
Influenza, Human
Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
OTUB1 Is a Key Regulator of RIG-I-Dependent Immune Signaling and Is Targeted for Proteasomal Degradation by Influenza A NS1.
Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication.
Insulinoma
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
Intellectual Disability
CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
First Replication of the Involvement of OTUD6B in Intellectual Disability Syndrome With Seizures and Dysmorphic Features.
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.
Intestinal Diseases
Berberine ameliorates NSAIDs-induced intestinal injury by the repair of enteric nervous system.
Expression of PGP 9.5 by Enteric Neurons in Horses and Donkeys with and without Intestinal Disease.
Intracranial Hemorrhage, Traumatic
Microwave scan and brain biomarkers to rule out intracranial hemorrhage: study protocol of a planned prospective study (MBI01).
Intracranial Hemorrhages
Investigation of UCH-L1 levels in ischemic stroke, intracranial hemorrhage and metabolic disorder induced impaired consciousness.
Ischemic Stroke
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
cPKC?-mediated down-regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK-mTOR pathway.
Diagnostic Accuracy of Glial Fibrillary Acidic Protein and Ubiquitin Carboxy-Terminal Hydrolase-L1 Serum Concentrations for Differentiating Acute Intracerebral Hemorrhage from Ischemic Stroke.
Different expression of ubiquitin C-terminal hydrolase-L1 and ?II-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.
Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1.
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
Investigation of UCH-L1 levels in ischemic stroke, intracranial hemorrhage and metabolic disorder induced impaired consciousness.
Joint Diseases
Increased concentrations of protein gene product 9.5 in the synovial fluid from horses with osteoarthritis.
Keratoacanthoma
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Kidney Diseases
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
The regulation of the UCH-L1 gene by transcription factor NF-?B in podocytes.
Kidney Neoplasms
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
Klatskin Tumor
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Leber Congenital Amaurosis
Biallelic mutations in USP45, encoding a deubiquitinating enzyme, are associated with Leber congenital amaurosis.
Leiomyoma
Comparison of Nerve Fiber Density between Patients with Uterine Leiomyoma with and without Pain: a Prospective Clinical Study.
Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids.
NT, NPY and PGP 9.5 presence in myomeytrium and in fibroid pseudocapsule and their possible impact on muscular physiology.
[A clinicopathologic and immunohistochemical study on 76 cases of gastrointestinal stromal tumors]
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
[Distribution of nerve fibers in endometrium and its clinical significance in adenomyosis]
Leiomyoma, Epithelioid
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
Leiomyosarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
Leishmaniasis, Visceral
IRAK-M regulates the inhibition of TLR-mediated macrophage immune response during late in vitro Leishmania donovani infection.
Leprosy
A comparison of the expression of NGFr, PGP 9.5 and NSE in cutaneous lesions of patients with early leprosy using immunohistochemistry.
The expression of NGFr and PGP 9.5 in leprosy reactional cutaneous lesions: an assessment of the nerve fiber status using immunostaining.
Leprosy, Multibacillary
Leprosy patients: neurotrophic factors and axonal markers in skin lesions.
Leukemia
Amyotrophic lateral sclerosis with neuronal intranuclear protein inclusions.
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys.
Small molecule inhibition of deubiquitinating enzyme JOSD1 as a novel targeted therapy for leukemias with mutant JAK2.
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
[Autophagy and Expression of UCH-L3 Induced by Rapamycin in HL-60 Cells].
Leukemia, Lymphocytic, Chronic, B-Cell
The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells.
Leukemia, Myeloid
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
Leukemia, Myeloid, Acute
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Leukemia, T-Cell
Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia.
Leukemia-Lymphoma, Adult T-Cell
The distribution of CD45R, CD29 and CD45RO (UCHL1) antigens in mature CD4 positive T-cell leukaemias.
Leukoencephalopathies
Changes of ubiquitin C-terminal hydrolase-L1 levels in serum and urine of patients with white matter lesions.
Lewy Body Disease
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
Lichen Planus, Oral
Disorder-specific changes in innervation in oral lichen planus and lichenoid reactions.
lipoprotein lipase deficiency
Lipoprotein lipase deficiency leads to ?-synuclein aggregation and ubiquitin C-terminal hydrolase L1 reduction.
Liposarcoma
Structural basis and specificity of human otubain 1-mediated deubiquitination.
Lissencephaly
CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
Listeriosis
CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production.
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD.
Liver Cirrhosis
Genetic polymorphisms in ataxin-3 and liver cirrhosis risk related to aflatoxin B1.
Liver Diseases
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Liver Diseases, Alcoholic
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
Liver Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
Knock-down of USP22 by small interfering RNA interference inhibits HepG2 cell proliferation and induces cell cycle arrest.
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-?B signaling.
Ubiquitin C-terminal hydrolase37 regulates Tcf7 DNA binding for the activation of Wnt signalling.
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
Lung Neoplasms
Acute damage by naphthalene triggers expression of the neuroendocrine marker PGP9.5 in airway epithelial cells.
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
BAP1 suppresses lung cancer progression and is inhibited by miR-31.
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R.
circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22.
Clinical value of seven autoantibodies combined detection in the diagnosis of lung cancer.
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Deubiquitinating enzyme USP41 promotes lung cancer cell proliferation and migration.
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Early detection of lung cancer by using an autoantibody panel in Chinese population.
Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
Expression patterns of USP22 and potential targets BMI-1, PTEN, p-AKT in non-small-cell lung cancer.
Finding Genes Discriminating Smokers from Non-smokers by Applying a Growing Self-organizing Clustering Method to Large Airway Epithelium Cell Microarray Data.
Identification of potential lung cancer biomarkers using an in vitro carcinogenesis model.
Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues.
MicroRNA-103a Curtails the Stemness of Non-Small Cell Lung Cancer Cells by Binding OTUB1 via the Hippo Signaling Pathway.
Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3.
N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.
Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Over-Expression of Deubiquitinating Enzyme USP14 in Lung Adenocarcinoma Promotes Proliferation through the Accumulation of ?-Catenin.
Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth.
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
Secretomic analysis of large cell lung cancer cell lines using two-dimensional gel electrophoresis coupled to mass spectrometry.
Sensitive detection of rare cancer cells in sputum and peripheral blood samples of patients with lung cancer by preproGRP-specific RT-PCR.
Serial analysis of gene expression in non-small cell lung cancer.
Silencing UCHL3 enhances radio-sensitivity of non-small cell lung cancer cells by inhibiting DNA repair.
Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.
SP1-mediated overexpression of lncRNA LINC01234 as a ceRNA facilitates non-small-cell lung cancer progression via regulating OTUB1.
Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor.
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-? signaling, inhibits dauer larva formation, and enhances lung tumorigenesis.
The role of seven autoantibodies in lung cancer diagnosis.
Ubiquitin C-terminal hydrolase L1 promotes expression of programmed cell death-ligand 1 in non-small-cell lung cancer cells.
Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers.
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.
Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1?.
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.
USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
[Effect of liposomal transfection of UCH-L1 siRNA on proliferation and apoptosis of lung cancer cell line H157]
[Establishment and characterization of A549 tumor monoclonal cell line with UCHL1 gene deletion].
Lupus Nephritis
A20 overexpression exerts protective effects on podocyte injury in lupus nephritis by downregulating UCH-L1.
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
The regulation of the UCH-L1 gene by transcription factor NF-?B in podocytes.
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Lymphatic Metastasis
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor ?1.
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma.
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics.
UCHL1 acts as a colorectal cancer oncogene via activation of the ?-catenin/TCF pathway through its deubiquitinating activity.
UCHL1 enhances the malignant development of glioma via targeting GAS2.
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Lymphocytosis
Investigation of bone marrow lymphocyte subsets in normal, reactive, and neoplastic states using paraffin-embedded biopsy specimens.
Lymphoma
A case of primary T-cell lymphoma of the duodenum.
Aberrant phenotypes in peripheral T cell lymphomas.
Analysis of DnaK Expression from a Strain of Mycoplasma fermentans in Infected HCT116 Human Colon Carcinoma Cells.
Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: presentation as minimal change disease.
Application of the cell block method, utilizing mount quick mounting medium.
Case of plasmablastic lymphoma of the sigmoid colon and literature review.
CD20 Positive T Cell Lymphoma Involvement of Skin.
Demonstration of lymphoid antigens in decalcified bone marrow trephines.
Diagnosis of gastrointestinal T-cell lymphomas in routinely processed tissues.
Epithelial changes following bone marrow transplantation: cytological atypia and epithelial endocrine cells.
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Fine needle aspiration (FNA) biopsy of orbital masses: a critical review of 51 cases.
Formalin-resistant leukocyte surface antigens in the diagnosis of cutaneous malignant lymphomas.
Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature.
Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections.
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4.
Immunoperoxidase staining of non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations.
Immunophenotypic analysis of sinonasal non-Hodgkin's lymphomas.
Immunophenotypic diagnosis of non-Hodgkin's lymphoma in paraffin sections. Co-expression of L60 (Leu-22) and L26 antigens correlates with malignant histologic findings.
Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study.
Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Large cell anaplastic lymphoma: evaluation of immunophenotype on paraffin and frozen sections in comparison with ultrastructural features.
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Merkel cell carcinoma: Is this a true carcinoma?
Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues.
Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.
Nasopharyngeal carcinomas and malignant lymphomas: an immunohistochemical analysis of 74 cases.
NK/T-cell lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus: an autopsy case.
Paraffin-immunohistochemical analysis of 226 non-Hodgkin's malignant lymphomas in the endemic area of human T-cell leukemia virus type 1.
Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin's lymphomas.
Pattern of malignant lymphomas in Rwanda.
Phenotypic analysis of malignant lymphoma in simian immunodeficiency virus infection using anti-human antibodies.
Primary esophageal non-Hodgkin's lymphoma.
Primary pulmonary collision tumor including squamous cell carcinoma and T-cell lymphoma.
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.
Sarcomatoid variant of anaplastic large cell lymphoma mimicking a primary breast cancer: a challenging diagnosis.
Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.
Stereotactic biopsy diagnosis of primary non-Hodgkin's lymphoma of the central nervous system. A histological and immunohistochemical study.
T-cell intravascular lymphomatosis (angiotropic large cell lymphoma): association with Epstein-Barr viral infection.
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
The double dealing of cyclin D1.
The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: lineage confirmed by JH rearrangement.
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC driven lymphomagenesis in mice.
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
UCHL1 (anti-T-cell) staining pattern in small intestinal lymphoma of coeliac disease.
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Use of monoclonal antibodies for the typing of malignant lymphomas in routinely processed biopsy samples.
[A case of sellar T cell type malignant lymphoma]
[Epstein-Barr virus associated Richter's syndrome accompanied by interstitial pneumonia]
[MALT-type lymphoma of lacrimal gland: case report]
[Midline malignant reticulosis: a histopathological, ultrastructural and immunohistochemical study of 11 cases]
[Primary malignant lymphoma of the rib; report of a case]
[Primary malignant T-cell-rich B-cell lymphoma of the central nervous system: a case report]
Lymphoma, B-Cell
Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: presentation as minimal change disease.
B-cell lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature.
How to differentiate between T-cell-rich B-cell lymphoma and lymphocyte-predominant Hodgkin's disease. Evidence for the value of MB1 and 4KB5 immunostaining.
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4.
Immunoperoxidase staining of non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations.
Investigation of bone marrow lymphocyte subsets in normal, reactive, and neoplastic states using paraffin-embedded biopsy specimens.
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Paraffin section immunophenotyping of non-Hodgkin's lymphoma, using a panel of monoclonal antibodies.
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Primary hepatic non-Hodgkin's lymphoma in a patient with chronic hepatitis C: report of a case.
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
Lymphoma, Large B-Cell, Diffuse
Primary hepatic non-Hodgkin's lymphoma in a patient with chronic hepatitis C: report of a case.
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Immunophenotypic analysis of non-Hodgkin's lymphoma.
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Non-Hodgkin's lymphoma: a histopathologic and immunohistochemical study of 79 cases.
Phenotyping of T-cell lymphomas in paraffin sections--which antibodies?
The value of immunophenotyping on paraffin sections in the identification of T-cell rich B-cell large-cell lymphomas: lineage confirmed by JH rearrangement.
[Pathological and clinical study of the primary B and T cell lymphomas of intestines]
Lymphoma, Primary Effusion
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Lymphoma, T-Cell
An immunocytochemical study of T-cell lymphomas using monoclonal and polyclonal antibodies effective in routinely fixed wax embedded tissues.
CD20 Positive T Cell Lymphoma Involvement of Skin.
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Immunohistochemical profile of cutaneous B-cell lymphoma on cryostat and paraffin sections.
Immunohistological analysis of the immunoreactivity of normal lymphoid cells and lymphomas with the monoclonal antibody OPD4.
Immunoperoxidase staining of non-Hodgkin's lymphomas for T-cell lineage associated antigens in paraffin sections. Comparison of the performance characteristics of four commercially available antibody preparations.
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Long-term survival in Ki-1 lymphoma.
Monoclonal antibodies marking T lymphocytes in paraffin-embedded tissue.
Paraffin section immunophenotyping of non-Hodgkin's lymphoma, using a panel of monoclonal antibodies.
Phenotyping of T-cell lymphomas in paraffin sections--which antibodies?
Primary esophageal non-Hodgkin's lymphoma.
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Lymphoma, T-Cell, Peripheral
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Machado-Joseph Disease
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.
A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic josephin domain in monomeric form, while leaving the oligomers unaffected.
A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.
A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins.
A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.
A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats.
Absence of ataxin-3 leads to enhanced stress response in C. elegans.
Accurate prediction of protein beta-aggregation with generalized statistical potentials.
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.
Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs.
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Association between Machado-Joseph disease and oxidative stress biomarkers.
Ataxin-3 and its e3 partners: implications for machado-joseph disease.
Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
Ataxin-3 interactions with rad23 and valosin-containing protein and its associations with ubiquitin chains and the proteasome are consistent with a role in ubiquitin-mediated proteolysis.
Ataxin-3 is subject to autolytic cleavage.
Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains.
Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.
Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies.
Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: Removal of the CAG containing exon.
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation.
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Attenuated nuclear shrinkage in neurons with nuclear aggregates--a morphometric study on pontine neurons of Machado-Joseph disease brains.
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Axonal inclusions in spinocerebellar ataxia type 3.
Brain stem and cerebellum volumetric analysis of Machado Joseph disease patients.
Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.
Broadening the therapeutic scope for rapamycin treatment.
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of Machado-Joseph disease.
Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3.
Casein kinase 2 interacts with and phosphorylates ataxin-3.
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3.
Conserved domains and lack of evidence for polyglutamine length polymorphism in the chicken homolog of the Machado-Joseph disease gene product ataxin-3.
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3.
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.
Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis.
Differential susceptibility of cultured cell lines to aggregate formation and cell death produced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3.
Distribution of amyloid-like and oligomeric species from protein aggregation kinetics.
Disulfiram facilitates ataxin-3 nuclear translocation and potentiates the cytotoxicity in a cell model of SCA3.
Divalproex sodium regulates ataxin-3 translocation likely by an importin ?1-dependent pathway.
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells.
Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.
Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.
Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3.
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3.
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3.
Functional interactions as a survival strategy against abnormal aggregation.
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Generation of induced pluripotent stem cells from a patient with spinocerebellar ataxia type 3.
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
Heterogeneous intracellular localization and expression of ataxin-3.
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Identification and functional dissection of localization signals within ataxin-3.
Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1.
Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado-Joseph disease| Spinocerebellar ataxia type 3.
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains.
Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Karyopherin ?-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease.
Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3? in a SCA3 Drosophila Model.
Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.
Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Magnetic resonance imaging demonstrates differential atrophy of pontine base and tegmentum in Machado-Joseph disease.
Major Improvements in Robustness and Efficiency during the Screening of Novel Enzyme Effectors by the 3-Point Kinetics Assay.
Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.
Mode of substrate recognition by the Josephin domain of ataxin-3, which has an endo-type deubiquitinase activity.
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.
Mouse models of Machado-Joseph disease and other polyglutamine spinocerebellar ataxias.
Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).
Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
Mutant Ataxin-3-Containing Aggregates (MATAGGs) in Spinocerebellar Ataxia Type 3: Dynamics of the Disorder.
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.
Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.
Novel polyglutamine model uncouples proteotoxicity from aging.
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Observation of liquid-liquid phase separation of ataxin-3 and quantitative evaluation of its concentration in a single droplet using Raman microscopy.
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome.
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine.
Pathological ATX3 Expression Induces Cell Perturbations in E. coli as Revealed by Biochemical and Biophysical Investigations.
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.
Physiological and pathophysiological characteristics of ataxin-3 isoforms.
Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease.
Polyglutamine expansion diseases: More than simple repeats.
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
Polyglutamine-Independent Features in Ataxin-3 Aggregation and Pathogenesis of Machado-Joseph Disease.
PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA-3.
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Proteotoxic stress increases nuclear localization of ataxin-3.
Purification of polyglutamine proteins.
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.
Research on screening and identification of proteins interacting with ataxin-3.
Reversibility of symptoms in a conditional mouse model of Spinocerebellar Ataxia Type 3.
RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.
RNA toxicity is a component of ataxin-3 degeneration in Drosophila.
RNAi therapy for Machado-Joseph disease: long-term safety profile of lentiviral vectors encoding shRNAs targeting mutant ataxin-3.
Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.
Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.
Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice.
Spinocerebellar Ataxia Type 3 (SCA3): Thalamic Neurodegeneration Occurs Independently from Thalamic Ataxin-3 Immunopositive Neuronal Intranuclear Inclusions.
Spinocerebellar ataxia type 3 in Israel: phenotype and genotype of a Jew Yemenite subpopulation.
ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.
Structural modeling of ataxin-3 reveals distant homology to adaptins.
Study of subcellular localization and proteolysis of ataxin-3.
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila.
T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.
Temperature profoundly affects ataxin-3 fibrillogenesis.
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.
The Machado-Joseph disease-associated form of ataxin-3 impacts dynamics of clathrin-coated pits.
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.
The role of the central flexible region on the aggregation and conformational properties of human ataxin-3.
The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis.
The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.
The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3.
The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Transcript Diversity of Machado-Joseph Disease Gene (ATXN3) Is Not Directly Determined by SNPs in Exonic or Flanking Intronic Regions.
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3.
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.
Upregulation of miR-25 and miR-181 Family Members Correlates with Reduced Expression of ATXN3 in Lymphocytes from SCA3 Patients.
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.
Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3.
Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.
[Screening for proteins interacting with ataxin-3, the gene product of SCA3/MJD]
Malaria
Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor ?-chain suggests involvement of endocytosis and membrane protein trafficking.
Experimentally Engineered Mutations in a Ubiquitin Hydrolase, UBP-1, Modulate In Vivo Susceptibility to Artemisinin and Chloroquine in Plasmodium berghei.
Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.
Mammalian Deubiquitinating Enzyme Inhibitors Display in Vitro and in Vivo Activity against Malaria Parasites and Potentiate Artemisinin Action.
Malaria, Cerebral
The Deubiquitinating Enzyme Cylindromatosis Dampens CD8(+) T Cell Responses and Is a Critical Factor for Experimental Cerebral Malaria and Blood-Brain Barrier Damage.
Malocclusion
Morphological changes in periodontal mechanoreceptors of mouse maxillary incisors after the experimental induction of anterior crossbite: a light and electron microscopic observation using immunohistochemistry for PGP 9.5.
Measles
Microwave antigen retrieval for immunocytochemistry on formalin-fixed, paraffin-embedded post-mortem CNS tissue.
Medulloblastoma
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Megacolon
Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon.
Melanoma
BAP1 expression is prognostic in breast and uveal melanoma but not colon cancer and is highly positively correlated with RBM15B and USP19.
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
BAP1 Germline Mutations in Finnish Patients with Uveal Melanoma.
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma.
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma.
Immunohistochemical and ultrastructural investigation on cutaneous neuroendocrine carcinoma: report of a case and review of the literature.
Interplay of the ubiquitin proteasome system and the innate immune response is essential for the replication of infectious bronchitis virus.
Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi.
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
Overview of BAP1 cancer predisposition syndrome and the relationship to uveal melanoma.
PGP 9.5, a new marker for human neuroendocrine tumours.
Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS.
Targeting the Proteasome-Associated Deubiquitinating Enzyme USP14 Impairs Melanoma Cell Survival and Overcomes Resistance to MAPK-Targeting Therapies.
The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.
Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA.
UCHL1 Regulates Melanogenesis through Controlling MITF Stability in Human Melanocytes.
UCHL3 plays an important role in the occurrence and development of melanoma.
Update in molecular diagnostics in melanocytic neoplasms.
USP22 deficiency in melanoma mediates resistance to T cells through IFN?-JAK1-STAT1 signal axis.
USP22 promotes melanoma and BRAF inhibitor resistance via YAP stabilization.
Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma.
Uveal Melanoma Nuclear BRCA1-Associated Protein-1 Immunoreactivity Is an Indicator of Metastasis.
Memory Disorders
Improving synaptic function in a mouse model of AD.
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.
Meningioma
Genetic Alterations Associated With Progression and Recurrence in Meningiomas.
Immunohistochemical Detection of CD34, E-cadherin, Claudin-1, Glucose Transporter 1, Laminin, and Protein Gene Product 9.5 in 28 Canine and 8 Feline Meningiomas.
Mesothelioma
A Novel BRCA1-Associated Protein-1 Isoform Affects Response of Mesothelioma Cells to Drugs Impairing BRCA1-Mediated DNA Repair.
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Cytoplasmic expression of BAP1 as an independent prognostic biomarker for patients with gliomas.
Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines.
Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Malignant Mesothelioma and Its Non-Asbestos Causes.
Mesotheliomas with deciduoid morphology: a morphologic spectrum and a variant not confined to young females.
Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
Mesothelioma, Malignant
Diagnostic value of BRCA1-associated protein-1, glucose transporter-1 and desmin expression in the discrimination between reactive mesothelial proliferation and malignant mesothelioma in tissues and effusions.
Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.
Microphthalmos
Cutaneous melanocytoneuroma: the first case of a distinctive intraneural tumor with dual nerve sheath and melanocytic differentiation.
Multiple myxoid cellular neurothekeomas in a patient with systemic lupus erythematosus.
Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information.
Movement Disorders
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).
Multiple Myeloma
A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance.
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15.
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.
Characterization of PMI-5011 on the Regulation of Deubiquitinating Enzyme Activity in Multiple Myeloma Cell Extracts.
Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease.
Targeting UCHL1 Induces Cell Cycle Arrest in High-Risk Multiple Myeloma with t(4;14).
The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells.
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction.
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression.
Multiple Sclerosis
A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.
Multiple System Atrophy
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
UCHL-1 gene in multiple system atrophy: a haplotype tagging approach.
Muscle Spasticity
Novel splice-site variant of UCHL1 in an Indian family with autosomal recessive spastic paraplegia-79.
Muscular Atrophy
Muscular atrophy, impaired epithelial autophagy and UCHL1 in androgen-deficient cauda epididymis.
The biology of A20-like molecules.
The preventive effect of ?-carotene on denervation-induced soleus muscle atrophy in mice.
UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle.
Muscular Atrophy, Spinal
Increased levels of UCHL1 are a compensatory response to disrupted ubiquitin homeostasis in spinal muscular atrophy and do not represent a viable therapeutic target.
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) regulates the level of SMN expression through ubiquitination in primary spinal muscular atrophy fibroblasts.
Muscular Diseases
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Mycosis Fungoides
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Immunophenotyping of cutaneous lymphoid infiltrates in frozen and paraffin-embedded tissue sections: a comparative study.
Myocardial Infarction
Cardiac sympathetic innervation and PGP9.5 expression by cardiomyocytes after myocardial infarction: effects of central MR blockade.
Induction of apoptosis and ubiquitin hydrolase gene expression by human serum factors in the early phase of acute myocardial infarction.
Myoclonic Epilepsies, Progressive
Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation.
Application of protein knockdown strategy targeting ?-sheet structure to multiple disease-associated polyglutamine proteins.
Non-expanded polyglutamine proteins in intranuclear inclusions of hereditary ataxias--triple-labeling immunofluorescence study.
Targeting several CAG expansion diseases by a single antisense oligonucleotide.
Myositis
Activation of the ubiquitin proteasome pathway in a mouse model of inflammatory myopathy: A potential therapeutic target.
Myxoma
Atrial myxoma: a tumour in search of its origins.
Nasopharyngeal Carcinoma
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
MiR-30e-5p inhibits proliferation and metastasis of nasopharyngeal carcinoma cells by target-ing USP22.
ShRNA-mediated silencing of the ubiquitin-specific protease 22 gene restrained cell progression and affected the Akt pathway in nasopharyngeal carcinoma.
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling, and is frequently silenced in nasopharyngeal carcinoma.
Neoplasm Metastasis
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4.
BAP1 Immunoreactivity Correlates with Gene Expression Class in Uveal Melanoma.
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
Crosstalk in cancer resistance and metastasis.
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF?-Induced Breast Cancer Metastasis.
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein.
Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Elevated expression of USP22 in correlation with poor prognosis in patients with invasive breast cancer.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
ERR? Regulates OTUB1 Expression to Promote Colorectal Cancer Cell Migration.
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma.
High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.
High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis.
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway.
LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
MiR-30e-5p inhibits proliferation and metastasis of nasopharyngeal carcinoma cells by target-ing USP22.
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
OTUB1 promotes esophageal squamous cell carcinoma metastasis through modulating Snail stability.
OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer.
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Prognostic significance of USP33 in advanced colorectal cancer patients: new insights into ?-arrestin-dependent ERK signaling.
Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma.
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway.
Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
The genetics of uveal melanoma: an emerging framework for targeted therapy.
The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer.
The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation.
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration.
Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor ?1.
Ubiquitin-specific peptidase 22 in cancer.
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma.
Ubiquitin-specific peptidase 46 promotes tumor metastasis through stabilizing ENO1 in human esophageal squamous cell carcinoma.
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics.
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
UCHL1 acts as a colorectal cancer oncogene via activation of the ?-catenin/TCF pathway through its deubiquitinating activity.
UCHL1 enhances the malignant development of glioma via targeting GAS2.
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1?.
UCHL3 stimulates metastasis of gastric cancer through upregulating IGF2.
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.
USP26 promotes esophageal squamous cell carcinoma metastasis through stabilizing Snail.
USP33 regulates c-Met expression by deubiquitinating SP1 to facilitate metastasis in hepatocellular carcinoma.
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Uveal Melanoma Nuclear BRCA1-Associated Protein-1 Immunoreactivity Is an Indicator of Metastasis.
Uveal Melanoma Treatment and Prognostication.
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Neoplasm, Residual
Detection of minimal residual disease by immunostaining of bone marrow biopsies after 2-chlorodeoxyadenosine for hairy cell leukemia.
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Neoplasms
A case of cutaneous Ki-1 positive anaplastic large cell lymphoma in a hemodialysed patient.
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival.
A fluorescence polarization-based competition assay for measuring interactions between unlabeled ubiquitin chains and UCH37•RPN13.
A neuroendocrine cause of oncogenic osteomalacia.
A new xenograft model of primary central nervous system lymphoma.
A Novel Link between Inflammation and Cancer.
A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases.
A novel type of deubiquitinating enzyme.
A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair.
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours.
A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma.
A substrate for deubiquitinating enzymes based on time-resolved fluorescence resonance energy transfer between terbium and yellow fluorescent protein.
Aberrant expression of USP22 is associated with liver metastasis and poor prognosis of colorectal cancer.
Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer.
Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma.
Activation and selectivity of OTUB-1 and OTUB-2 deubiquitinylases.
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines.
Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.
Adult-onset neuroblastoma: Report of seven cases with molecular genetic characterization.
Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics.
Amphicrine differentiation in bronchioloalveolar cell carcinoma.
An autopsy case of so-called midline malignant reticulosis followed by extensive dissemination with immunohistochemical evidence for its T cell malignancy.
An emerging model for BAP1's role in regulating cell cycle progression.
An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases.
An upregulation of SENP3 after spinal cord injury: implications for neuronal apoptosis.
Angiotropic large cell lymphoma (intravascular malignant lymphomatosis) of the kidney: presentation as minimal change disease.
Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.
Application of the cell block method, utilizing mount quick mounting medium.
Argyrophilic nucleolar organiser region counts and prognosis in pharyngeal carcinoma.
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Atrial myxoma: a tumour in search of its origins.
ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
BaBao Dan Suppresses Tumor Growth of Pancreatic Cancer Through Modulating Transcriptional Reprogramming of Cancer-Related Genes.
BAP1 functions as a tumor promoter in prostate cancer cells through EMT regulation.
BAP1 hereditary cancer predisposition syndrome: a case report and review of literature.
BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response.
Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.
BAP1 is phosphorylated at serine 592 in S-phase following DNA damage.
BAP1 links metabolic regulation of ferroptosis to tumour suppression.
BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
BAP1 suppresses lung cancer progression and is inhibited by miR-31.
BAP1/ASXL1 recruitment and activation for H2A deubiquitination.
BAP1: Not just a BRCA1-associated protein.
Binding of SARS-CoV Covalent Non-Covalent Inhibitors to the SARS-CoV-2 Papain-Like Protease and Ovarian Tumor Domain Deubiquitinases.
Biochemical and cellular characterization of a cyanopyrrolidine covalent Ubiquitin C-terminal hydrolase L1 inhibitor.
Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.
Blocking PD-L1 for anti-liver cancer immunity: USP22 represents a critical cotarget.
BRCA1-associated protein 1 deficiency in lung adenocarcinoma predicts poor outcome and increased tumor invasion.
BRCA1-associated protein 1 expression and prognostic role in prostate adenocarcinoma.
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization.
BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancer.
CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.
Cerebellar cortical degeneration in association with small-cell carcinoma of the oesophagus.
Cezanne contributes to cancer progression by playing a key role in the deubiquitination of IGF-1R.
Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma.
Cezanne/OTUD7B is a cell cycle-regulated deubiquitinase that antagonizes the degradation of APC/C substrates.
Characterization of PMI-5011 on the Regulation of Deubiquitinating Enzyme Activity in Multiple Myeloma Cell Extracts.
CHIP and BAP1 Act in Concert to Regulate INO80 Ubiquitination and Stability for DNA Replication.
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth.
Clinicopathological characteristics and molecular abnormalities of primary grade 2 neuroendocrine tumors of the cervix.
Cloning and characterization of the human USP22 gene promoter.
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.
Commentary on BRCA1-Associated Protein-1 Tumor Predisposition Syndrome in a Patient With Numerous Basal Cell Carcinomas.
Comparative study of seven neuroendocrine markers in pancreatic endocrine tumours.
Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma.
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases.
Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide.
Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer.
Construction of hu-PBL/SCID chimeras and development of EBV-related lymphomas.
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells.
COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.
Correction: Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Could Dysregulation of UPS be a Common Underlying Mechanism for Cancer and Neurodegeneration? Lessons from UCHL1.
CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma.
CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.
CRISPR screen in regulatory T cells reveals modulators of Foxp3.
Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress.
Crosstalk in cancer resistance and metastasis.
Crystallization and preliminary X-ray crystallographic analysis of the complex between the N-D1 domain of VCP from Homo sapiens and the N domain of OTU1 from Saccharomyces cerevisiae.
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.
CYLD and HCC: when being too sensitive to your dirty neighbors results in self-destruction.
CYLD in ubiquitin signaling and tumor pathogenesis.
CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.
CYLD: a DUB with many talents.
Decreased Cezanne expression is associated with the progression and poor prognosis in hepatocellular carcinoma.
Decreased H2B monoubiquitination and overexpression of ubiquitin-specific protease enzyme 22 in malignant colon carcinoma.
Decreased UCHL1 expression as a cytologic biomarker for aggressive behavior in pancreatic neuroendocrine tumors.
Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.
Demonstration of lymphoid antigens in decalcified bone marrow trephines.
Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.
Detection of B- and T-cells in paraffin-embedded tissue sections. Diagnostic utility of commercially obtained 4KB5 and UCHL-1.
Deubiquitinase Activity Profiling Identifies UCHL1 as a Candidate Oncoprotein That Promotes TGF?-Induced Breast Cancer Metastasis.
Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Deubiquitinase PSMD14 enhances hepatocellular carcinoma growth and metastasis by stabilizing GRB2.
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Deubiquitinase UCHL5 is elevated and associated with a poor clinical outcome in lung adenocarcinoma (LUAD).
Deubiquitinating enzyme inhibitors and their potential in cancer therapy.
Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1.
Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.
Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.
Deubiquitinating enzyme USP46 suppresses the progression of hepatocellular carcinoma by stabilizing MST1.
Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.
Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity.
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Deubiquitination of the repressor E2F6 by USP22 facilitates AKT activation and tumor growth in hepatocellular carcinoma.
Development of prognostic models for patients with traumatic brain injury: a systematic review.
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.
Diagnostic findings of bronchial brush cytology for pulmonary large cell neuroendocrine carcinomas: comparison with poorly differentiated adenocarcinomas, squamous cell carcinomas, and small cell carcinomas.
Diagnostic immunohistochemistry of neuroblastic tumors.
Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3.
Differential survival trends of stage II colorectal cancer patients relate to promoter methylation status of PCDH10, SPARC, and UCHL1.
Differentiation of reactive from neoplastic small-cell lymphoid aggregates in paraffin-embedded marrow particle preparations using L-26 (CD20) and UCHL-1 (CD45RO) monoclonal antibodies.
Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition.
Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity.
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme.
Disseminated retinoblastoma successfully treated with myeloablative chemotherapy--implication for molecular detection of minimal residual disease.
Divergence in Ubiquitin Interaction and Catalysis among the Ubiquitin-Specific Protease Family Deubiquitinating Enzymes.
Diverse roles of the E2/E3 hybrid enzyme UBE2O in the regulation of protein ubiquitination, cellular functions, and disease onset.
DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB.
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival.
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
DUBA: a deubiquitinase that regulates type I interferon production.
DUBbing Ferroptosis in Cancer Cells.
Early phase TGF? receptor signalling dynamics stabilised by the deubiquitinase UCH37 promotes cell migratory responses.
Endocrine differentiation of extra-pulmonary small cell carcinoma demonstrated by immunohistochemistry using antibodies to PGP 9.5, neuron-specific enolase and the C-flanking peptide of human pro-bombesin.
Enzymatic Characterisation of USP7 Deubiquitinating activity and Inhibition.
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia.
Establishment of cell lines with porcine spermatogonial stem cell properties.
Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.
Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma.
Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells.
Expression and functional implications of USP17 in glioma.
Expression and functional studies of ubiquitin C-terminal hydrolase L1 regulated genes.
Expression of CYLD and NF-kappaB in human cholesteatoma epithelium.
Expression of HAUSP in gliomas correlates with disease progression and survival of patients.
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
Expression of nse and pgp-9.5 in nonsmall-cell lung-cancers.
Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion.
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Expression of the protein gene product 9.5, PGP9.5, is correlated with T-status in non-small cell lung cancer.
Expression of USP22 and Survivin is an indicator of malignant behavior in hepatocellular carcinoma.
Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.
Extraskeletal myxoid chondrosarcoma: a light microscopic, immunohistochemical, ultrastructural and immuno-ultrastructural study indicating neuroendocrine differentiation.
Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.
First Replication of the Involvement of OTUD6B in Intellectual Disability Syndrome With Seizures and Dysmorphic Features.
Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.
Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma.
Frequent mutation of BAP1 in metastasizing uveal melanomas.
Friend or Foe: UCHL3 Mediated Carcinogenesis and Current Approaches in Small Molecule Inhibitors' Development.
Function of Deubiquitinating Enzyme USP14 as Oncogene in Different Types of Cancer.
Functions of SAGA in development and disease.
Gastrointestinal stromal tumors--a recently defined entity. Literature data and personal case report.
Gene of the month: BAP1.
Generation of Rat Monoclonal Antibodies Against a Deubiquitinase, Ovarian Tumor Domain-Containing Protein 1.
Genetic parkinsonisms and cancer: a systematic review and meta-analysis.
Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
Genomic, prognostic, and cell-signaling advances in uveal melanoma.
Gonadoblastoma in the Ovaries of a Lesser Galago (Galago senegalensis braccatus).
Granular cell tumor (Abrikossoff tumor) of the thyroid gland.
Granular cell tumors of the tongue: fibroma or schwannoma.
HAUSP as a therapeutic target for hematopoietic tumors (review).
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma.
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma.
High expression of FOXM1 critical for sustaining cell proliferation in mitochondrial DNA-less liver cancer cells.
High Expression of Ubiquitin C-terminal Hydrolase L1 Is Associated With Poor Prognosis in Endometrial Cancer Patients.
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer.
High expression of ubiquitin carboxyl-terminal hydrolase 22 is associated with poor prognosis in hepatitis B virus-associated liver cancer.
High expression of UCH37 is significantly associated with poor prognosis in human epithelial ovarian cancer.
High expression of USP22 predicts poor prognosis and advanced clinicopathological features in solid tumors: a meta-analysis.
High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.
High USP22 expression indicates poor prognosis in hepatocellular carcinoma.
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog.
Histologically Diverse BAP1-Deficient Melanocytic Tumors in a Patient With BAP1 Tumor Predisposition Syndrome.
HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.
Human papillomavirus (HPV) upregulates the cellular deubiquitinase UCHL1 to suppress the keratinocyte's innate immune response.
Hyaluronan binding motifs of USP17 and SDS3 exhibit anti-tumor activity.
Hypermethylation of UCHL1 Promotes Metastasis of Nasopharyngeal Carcinoma by Suppressing Degradation of Cortactin (CTTN).
Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features.
Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.
Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy.
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase.
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening.
Identification of methylation-silenced genes in colorectal cancer cell lines: Genomic screening using oligonucleotide arrays.
Identifying apoptosis-evasion proteins/pathways in human hepatoma cells via induction of cellular hormesis by UV irradiation.
Ileal mucosa-associated lymphoid tissue lymphoma showing several ulcer scars detected using double-balloon endoscopy.
Immunohistochemical analysis of diethylstilbestrol-induced renal tumors in adult male Syrian hamsters: evidence for relationship to peripheral nerve sheath tumors.
Immunohistochemical analysis of equine pulmonary granular cell tumours.
Immunohistochemical detection of protein gene product 9.5 (PGP 9.5) in canine epitheliotropic T-cell lymphoma (mycosis fungoides).
Immunohistochemical Expression of Melanocytic Antigen PNL2, Melan A, S100, and PGP 9.5 in Equine Melanocytic Neoplasms.
Immunophenotypic diagnosis of non-Hodgkin's lymphoma in paraffin sections. Co-expression of L60 (Leu-22) and L26 antigens correlates with malignant histologic findings.
Immunophenotyping of hematopoietic malignancies in paraffin sections.
Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.
Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas.
Impressionist portraits of mitotic exit: APC/C, K11-linked ubiquitin chains and Cezanne.
Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.
Increased expression of ubiquitin-specific protease 22 can promote cancer progression and predict therapy failure in human colorectal cancer.
Inferring synthetic lethal interactions from mutual exclusivity of genetic events in cancer.
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency.
Inhibitory Effect of the HPV-16mE6Delta/mE7/TBhsp70Delta Vaccine on Oral Squamous Cell Carcinoma.
Insights into the Porcine Reproductive and Respiratory Syndrome Virus Viral Ovarian Tumor Domain Protease Specificity for Ubiquitin and Interferon Stimulated Gene Product 15.
Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).
Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors.
Isopeptidase Kinetics Determination by a Real Time and Sensitive qFRET Approach.
Knock-down of ubiquitin-specific protease 22 by micro-RNA interference inhibits colorectal cancer growth.
Knockdown of otubain 2 inhibits liver cancer cell growth by suppressing NF-?B signaling.
Knockdown of ubiquitin?specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc?finger E?box binding homeobox 1.
Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.
KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.
Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi.
Large (>3.8 cm) clear cell renal cell carcinomas are morphologically and immunohistochemically heterogeneous.
Large cell lymphoma of the mediastinum with marked tropism for germinal centers.
Large-cell neuroendocrine carcinoma of the ampulla of Vater.
Large-scale analysis of BAP1 expression reveals novel associations with clinical and molecular features of malignant pleural mesothelioma.
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma.
Loss of CYLD might be associated with development of salivary gland tumors.
Loss of CYLD promotes cell invasion via ALK5 stabilization in oral squamous cell carcinoma.
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
Loss of Tumor Suppressor CYLD Expression Triggers Cisplatin Resistance in Oral Squamous Cell Carcinoma.
Malignant Mesothelioma and Its Non-Asbestos Causes.
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
Malignant peritoneal mesothelioma: clinical aspects, and therapeutic perspectives.
Mechanism of pain and cytoskeletal properties in angioleiomyomas: an immunohistochemical study.
Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11.
Medulloblastoma. An immunohistological study of 50 cases.
Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.
Methylation status in the promoter region of the human PGP9.5 gene in cancer and normal tissues.
Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
MicroRNA-30e-5p suppresses non-small cell lung cancer tumorigenesis by regulating USP22-mediated Sirt1/JAK/STAT3 signaling.
miR-34b inhibits nasopharyngeal carcinoma cell proliferation by targeting ubiquitin-specific peptidase 22.
MiR-4782-3p inhibited non-small cell lung cancer growth via USP14.
MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers.
Molecular Characteristics of Large Parathyroid Adenomas.
Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis.
Molecular pathogenesis of malignant mesothelioma.
Monoclonal antibody Leu-22 (L60) permits the demonstration of some neoplastic T cells in routinely fixed and paraffin-embedded tissue sections.
Monoclonal antibody OPD4 detects neoplastic T cells but does not distinguish between CD4 and CD8 neoplastic T cells in paraffin tissue sections.
Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma.
Nasal natural killer/T cell lymphoma with cutaneous involvement: case report and Chinese literature review reported in China mainland.
Negative Parafibromin Staining Predicts Malignant Behavior in Atypical Parathyroid Adenomas.
Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.
Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma.
Neuroendocrine Carcinomas of the Canine Mammary Gland: Histopathological and Immunohistochemical Characteristics.
Neurofibromatosis type I with malignant peripheral nerve sheath tumors in the upper arm: A case report.
New Methylation Biomarker Panel for Early Diagnosis of Dysplasia or Cancer in High-Risk Inflammatory Bowel Disease Patients.
Novel cell lines established from pediatric brain tumors.
Nuclear ubiquitin C-terminal hydrolase L5 expression associates with increased patient survival in pancreatic ductal adenocarcinoma.
Olfactory neuroblastoma: clinical and pathological aspects.
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.
Operative ubiquitin-specific protease 22 deubiquitination confers a more invasive phenotype to cholangiocarcinoma.
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
OTUB1 knockdown promotes apoptosis in melanoma cells by upregulating TRAIL expression
OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1.
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.
OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers.
OTUB1 stabilizes mismatch repair protein MSH2 by blocking ubiquitination.
OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.
OTUB1-mediated deubiquitination of FOXM1 up-regulates ECT-2 to promote tumor progression in renal cell carcinoma.
OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.
OTUB2 Promotes Homologous Recombination Repair Through Stimulating Rad51 Expression in Endometrial Cancer.
OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.
Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer.
OTUD5 Variants Associated With X-Linked Intellectual Disability and Congenital Malformation.
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells.
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway.
Overexpression of ubiquitin specific peptidase 14 predicts unfavorable prognosis in esophageal squamous cell carcinoma.
Overexpression of ubiquitin specific proteases 44 promotes the malignancy of glioma by stabilizing tumor-promoter securin.
Overexpression of ubiquitin-specific protease 22 predicts poor survival in patients with early-stage non-small cell lung cancer.
Overexpression of USP5 contributes to tumorigenesis in non-small cell lung cancer via the stabilization of ?-catenin protein.
Overview of BAP1 cancer predisposition syndrome and the relationship to uveal melanoma.
Paraganglioma of the urinary bladder: a challenging diagnosis in transurethral resection specimens: a case report.
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth.
Pediatric sex cord-stromal tumor with composite morphology: a case report.
Performance Evaluation of an Enzyme-Linked Immunosorbent Assay for Seven Autoantibodies in Lung Cancer.
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
PGP 9.5 immunocytochemical staining for pancreatic endocrine tumors.
PGP 9.5, a new marker for human neuroendocrine tumours.
PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.
PGP9.5 as a marker for invasive colorectal cancer.
PGP9.5 as a prognostic factor in pancreatic cancer.
PGP9.5 methylation as a marker for metastatic colorectal cancer.
PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma.
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13.
PKA/CREB regulates the constitutive promoter activity of the USP22 gene.
Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy.
Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma.
Plasticity of neuropeptidergic neoplasm cells in the primary and metastatic Merkel cell carcinoma.
Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling.
Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Power and promise of ubiquitin carboxyl-terminal hydrolase 37 as a target of cancer therapy.
Premature aging and cancer development in transgenic mice lacking functional CYLD.
Primary central nervous system involvement of the so called 'peripheral T-cell lymphoma'. Report of a case and review of the literature.
Primary central nervous system lymphoma following transfer of human peripheral blood lymphocytes into SCID mice.
Primary cutaneous malignant perivascular epithelioid cell tumor: Case of a rare tumor with review of the literature.
Primary cutaneous neuroendocrine carcinoma (Merkel cell tumor). An adnexal epithelial neoplasm.
Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature.
Primary esophageal non-Hodgkin's lymphoma.
Primary extranodal non-Hodgkin's lymphoma of the oral region.
Primary hepatic anaplastic large-cell lymphoma of T-cell phenotype in acquired immunodeficiency syndrome: a report of an autopsy case and review of the literature.
Primary pulmonary lymphoma diagnosed by gene rearrangement: report of a case.
Primary T-cell lymphoma of the central nervous system.
Primitive nonneural granular cell tumor (so-called atypical polypoid granular cell tumor). Report of 2 cases with immunohistochemical and ultrastructural correlation.
Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.
Production of polyclonal anti-dUCH (Drosophila Ubiquitin Carboxyl-terminal Hydrolase) antibodies.
Prognoses and Clinical Outcomes of Primary and Recurrent Uveal Melanoma.
Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis.
Prognostic potential and oncogenic effects of UCH-L1 expression in hilar cholangiocarcinoma.
Prognostic relevance of UCH-L1 and ?-internexin in pancreatic neuroendocrine tumors.
Prognostic significance of BAP1 expression in high-grade upper tract urothelial carcinoma: a multi-institutional study.
Prognostic significance of BRCA1-associated protein 1 in colorectal cancer.
Prognostic significance of USP10 as a tumor-associated marker in gastric carcinoma.
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Promoter hypermethylation of tumor suppressor genes in serum as potential biomarker for the diagnosis of nasopharyngeal carcinoma.
Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma.
Proteasome Ubiquitin Receptor hRpn13 and its Interacting Deubiquitinating Enzyme Uch37 are Required for Proper Cell Cycle Progression.
Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD.
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.
Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma.
Protein gene product 9.5 (PGP9.5) immunoreactivity in salivary gland tumors.
Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP.
Proteome Analysis of USP7 Substrates Revealed Its Role in Melanoma Through PI3K/Akt/FOXO and AMPK Pathways.
Proteomic analysis of ?-asarone induced cytotoxicity in human glioblastoma U251 cells.
Proteomic analysis of secreted proteins of non-small cell lung cancer.
Proteomics-based identification of protein gene product 9.5 as a tumor antigen that induces a humoral immune response in lung cancer.
PTOV1 is associated with UCH-L1 and in response to estrogen stimuli during the mouse oocyte development.
PU.1-dependent regulation of UCH L1 expression in B-lymphoma cells.
Pulmonary large cell carcinoma expressing neuroendocrine markers: the morphological, biological, and neuroendocrine features of their cell lines and surgical cases.
Rare occurrence of biallelic CYLD gene mutations in classical Hodgkin lymphoma.
Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis.
Reduced USP22 Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.
Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
Regulation of post-translational modification in breast cancer treatment.
Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation.
Regulation of USP28 deubiquitinating activity by SUMO conjugation.
RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer.
Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice.
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
Role of urokinase plasminogen activator and its receptor in metastasis and invasion of neuroblastoma.
Sarcomatoid variant of anaplastic large-cell Ki-1 lymphoma.
Sebaceous carcinoma of the breast: case report and review of the literature.
Selection of tumor?resistant variants following sustained natural killer cell?mediated immune stress.
Selection preserves Ubiquitin Specific Protease 4 alternative exon skipping in therian mammals.
Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).
Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.
Sensitive detection of rare cancer cells in sputum and peripheral blood samples of patients with lung cancer by preproGRP-specific RT-PCR.
Serial analysis of gene expression in non-small cell lung cancer.
Serum response factor controls CYLD expression via MAPK signaling pathway.
Serum ST2 as a potential prognostic biomarker for traumatic brain injury.
Silencing of OTUB1 inhibits migration of human glioma cells in vitro.
Silencing of the UCHL1 gene in giant cell tumors of bone.
Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) Tumors.
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells.
Stabilization and targeting of INO80 to replication forks by BAP1 during normal DNA synthesis.
Stabilization of MCRS1 by BAP1 prevents chromosome instability in renal cell carcinoma.
Steady-state kinetic studies reveal that the anti-cancer target Ubiquitin-Specific Protease 17 (USP17) is a highly efficient deubiquitinating enzyme.
Stimulation of the murine Uchl1 gene promoter by the B-Myb transcription factor.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Structural Basis for the Activation of the Deubiquitinase Calypso by the Polycomb Protein ASX.
Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets.
Substrate recognition and catalysis by UCH-L1.
Sulawesins A-C, Furanosesterterpene Tetronic Acids That Inhibit USP7, from a Psammocinia sp. Marine Sponge.
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Survey of differentially methylated promoters in prostate cancer cell lines.
Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors.
T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops).
Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells.
Targeting homologous recombination (HR) repair mechanism for cancer treatment: discovery of new potential UCHL-3 inhibitors via virtual screening, molecular dynamics and binding mode analysis.
Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.
Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
TGF-?1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells.
The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation.
The Akt DUBbed InAktive.
The Co-expression of USP22 and BMI-1 May Promote Cancer Progression and Predict Therapy Failure in Gastric Carcinoma.
The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate notch signalling.
The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
The deubiquitinase OTUD3 stabilizes ACTN4 to drive growth and metastasis of hepatocellular carcinoma.
The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells.
The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.
The deubiquitinating enzyme activity of USP22 is necessary for regulating HeLa cell growth.
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.
The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
The Deubiquitinating Enzyme UCHL1 Induces Resistance to Doxorubicin in HER2+ Breast Cancer by Promoting Free Fatty Acid Synthesis.
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase.
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
The Deubiquitinating Enzyme USP14 Regulates Leukemic Chemotherapy Drugs-Induced Cell Apoptosis by Suppressing Ubiquitination of Aurora Kinase B.
The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.
The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11.
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor.
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.
The expression of tumor suppressor gene Cyld is upregulated by histone deacetylace inhibitors in human hepatocellular carcinoma cell lines.
The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon.
The immunolocalization of PGP 9.5 in normal human kidney and renal cell carcinoma.
The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-?B pathway.
The neuronal marker protein gene product 9.5 (PGP 9.5) is phenotypically expressed in human breast epithelium, in milk, and in benign and malignant breast tumors.
The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.
The potential role of TNFAIP3 in malignant transformation of gastric carcinoma.
The potential role of ubiquitin c-terminal hydrolases in oncogenesis.
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression.
The relationship between the expression of USP22, BMI1, and EZH2 in hepatocellular carcinoma and their impacts on prognosis.
The role of PGP9.5 as a tumor suppressor gene in human cancer.
The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review.
The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death.
The significance of PGP 9.5 in tumours--an immunohistochemical study of gastrointestinal stromal tumours.
The solution structure of the ZnF UBP domain of USP33/VDU1.
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling, and is frequently silenced in nasopharyngeal carcinoma.
The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response.
The ubiquitin C-terminal hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation.
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.
The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes.
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
The USP22 promotes the growth of cancer cells through the DYRK1A in pancreatic ductal adenocarcinoma.
The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference.
Thymic B-cell non-Hodgkin's lymphoma in a child.
Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner.
Transgenic mouse model: a new approach for the investigation of endocrine pancreatic B-cell growth.
Trichostatin A, a histone deacetylase inhibitor, reduces lesion growth and hyperalgesia in experimentally induced endometriosis in mice.
Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.
Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses.
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes.
Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.
Tumor Suppressor Function of PGP9.5 Is Associated with Epigenetic Regulation in Prostate Cancer--Novel Predictor of Biochemical Recurrence after Radical Surgery.
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation, Independent of its Hydrolase Activity.
Ubiquitin C-terminal hydrolase l1 in tumorigenesis.
Ubiquitin C-Terminal Hydrolase L5 (UCHL5) Accelerates the Growth of Endometrial Cancer via Activating the Wnt/?-Catenin Signaling Pathway.
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Ubiquitin C-terminal hydrolase-L1 has prognostic relevance and is a therapeutic target for high-grade neuroendocrine lung cancers.
Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.
Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis.
Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4.
Ubiquitin C-Terminal Hydrolase-L1 Potentiates Cancer Chemosensitivity by Stabilizing NOXA.
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Ubiquitin carboxy-terminal hydrolase L1 - physiology and pathology.
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors.
Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases.
Ubiquitin carboxyl terminal hydrolase L1 negatively regulates TNFalpha-mediated vascular smooth muscle cell proliferation via suppressing ERK activation.
Ubiquitin carboxyl-terminal esterase L1 (UCHL1) is associated with stem-like cancer cell functions in pediatric high-grade glioma.
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation.
Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression.
Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models.
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.
Ubiquitin COOH-terminal hydrolase 1: a biomarker of renal cell carcinoma associated with enhanced tumor cell proliferation and migration.
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma.
Ubiquitin specific peptidase 33 promotes cell proliferation and reduces apoptosis through regulation of the SP1/PI3K/AKT pathway in retinoblastoma.
Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor ?1.
Ubiquitin Specific Protease 29 Functions as an Oncogene Promoting Tumorigenesis in Colorectal Carcinoma.
Ubiquitin-specific peptidase 22 in cancer.
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer.
Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1.
Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner.
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization.
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1.
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer.
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.
Ubiquitin-specific protease 4 promotes hepatocellular carcinoma progression via cyclophilin A stabilization and deubiquitination.
Ubiquitin-specific protease 44 inhibits cell growth by suppressing AKT signaling in non-small cell lung cancer.
Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis.
Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma.
Ubiquitin?specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial?mesenchymal transition.
Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.
UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC driven lymphomagenesis in mice.
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
UCH-L1 involved in regulating the degradation of EGFR and promoting malignant properties in drug-resistant breast cancer.
UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway.
UCH-L1-mediated Down-regulation of Estrogen Receptor ? Contributes to Insensitivity to Endocrine Therapy for Breast Cancer.
UCH-L3 promotes non-small cell lung cancer proliferation via accelerating cell cycle and inhibiting cell apoptosis.
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology.
UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression.
UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance.
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1?.
UCHL1 regulates inflammation via MAPK and NF-?B pathways in LPS-activated macrophages.
UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.
UCHL3 plays an important role in the occurrence and development of melanoma.
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.
UCHL3 promotes proliferation of colorectal cancer cells by regulating SOX12 via AKT/mTOR signaling pathway.
UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.
Unsuspected gastric granulocytic sarcoma in a patient with myelodysplastic syndrome.
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers.
Upregulation of the Non-Coding RNA OTUB1-isoform 2 Contributes to Gastric Cancer Cell Proliferation and Invasion and Predicts Poor Gastric Cancer Prognosis.
Upregulation of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Mediates the Reversal Effect of Verapamil on Chemo-Resistance to Adriamycin of Hepatocellular Carcinoma.
Upregulation of USP11 promotes epithelial?to?mesenchymal transition by deubiquitinating Snail in ovarian cancer.
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Use of monoclonal antibodies for the typing of malignant lymphomas in routinely processed biopsy samples.
Usefulness of serum interleukin-33 as a prognostic marker of severe traumatic brain injury.
USP10 Expression in Normal Adrenal Gland and Various Adrenal Tumors.
USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability.
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
USP19 is a ubiquitin-specific protease regulated in rat skeletal muscle during catabolic states.
USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer.
USP19 suppresses cellular type I interferon signaling by targeting TRAF3 for deubiquitination.
USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.
USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway.
USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.
USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination.
USP22 deficiency in melanoma mediates resistance to T cells through IFN?-JAK1-STAT1 signal axis.
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway.
USP22 drives colorectal cancer invasion and metastasis via epithelial-mesenchymal transition by activating AP4.
USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.
USP22 Interacts with PALB2 and Promotes Chemotherapy Resistance via Homologous Recombination of DNA Double-Strand Breaks.
USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Usp22 Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.
USP22 promotes development of lung adenocarcinoma through ubiquitination and immunosuppression.
USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.
USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response.
USP22 promotes NSCLC tumorigenesis via MDMX up-regulation and subsequent p53 inhibition.
USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma.
USP22 promotes tumor progression and induces epithelial-mesenchymal transition in lung adenocarcinoma.
USP22 regulates oncogenic signaling pathways to drive lethal cancer progression.
USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A.
USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer.
USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
USP44 Stabilizes DDB2 to Facilitate Nucleotide Excision Repair and Prevent Tumors.
USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1.
USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/?-catenin pathway via Axin1 deubiquitination.
USP5 Promotes Metastasis in Non-Small Cell Lung Cancer by Inducing Epithelial-Mesenchymal Transition via Wnt/?-Catenin Pathway.
USP7 manipulation by viral proteins.
USP7: Structure, substrate specificity, and inhibition.
Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
Uveal Melanoma Treatment and Prognostication.
Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study.
[A case of amelanotic melanoma of the nasal cavity]
[A case of sellar T cell type malignant lymphoma]
[A clinicopathologic and immunohistochemical study on 76 cases of gastrointestinal stromal tumors]
[B precursor lymphoblastic leukemia/lymphoma manifested at onset as hemophagocytic syndrome]
[Clinicopathological, immunohistochemical and molecular genetic study of intra-abdomen extra-gastrointestinal stromal tumors]
[Early diagnosis of subtype in early clinical stage lung adenocarcinoma by using an autoantibody panel and computed tomography].
[Effects of LAK cells activated by IL-2 on MCF-7 human breast cancer cell line maintained in organotypic culture]
[Establishment and characterization of A549 tumor monoclonal cell line with UCHL1 gene deletion].
[Expression levels of ubiquitin C-terminal hydrolase-L1 and serum glial fibrillary acidic protein and its clinical significance in patients with acute cerebral infarction].
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
[Identifying Inhibitors of USP7-HDM2 Protein-Protein Interaction (PPI) by the in Silico Fragment-mapping Method].
[Influence of UCHL5 on proliferation and apoptosis of SW527 breast cancer cells].
[Primary malignant lymphoma of the rib; report of a case]
[Primary primitive neuroectodermal tumor of the kidney in an adult. Clinico-pathologic and immunohistochemical case report]
[The histopathology and immunohistochemistry of granular cell tumour. A study of 12 cases with a brief historical note].
[UCH-L3 Expression in Epithelial Ovarian Cancer and Its Clinical Significance].
Neoplasms, Germ Cell and Embryonal
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Neoplastic Processes
Immunohistochemical evaluation of neoplasms in bone marrow biopsies using monoclonal antibodies reactive in paraffin-embedded tissue.
Neoplastic Syndromes, Hereditary
Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases.
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation.
Malignant Peripheral Nerve Sheath Tumor in a Patient With BAP1 Tumor Predisposition Syndrome.
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.
Nephritis
NF-?B upregulates ubiquitin C-terminal hydrolase 1 in diseased podocytes in glomerulonephritis.
Wnt/?-Catenin Signaling Mediated-UCH-L1 Expression in Podocytes of Diabetic Nephropathy.
Nephrosis, Lipoid
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies.
UCH-L1 expression of podocytes in diseased glomeruli and in vitro.
Nephrotic Syndrome
Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice.
Nerve Sheath Neoplasms
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Protein gene product 9.5 (PGP 9.5) is not a specific marker of neural and nerve sheath tumors: an immunohistochemical study of 95 mesenchymal neoplasms.
Nervous System Diseases
A survey of trinucleotide/tandem repeat-containing transcripts (TNRTs) isolated from human spinal cord to identify genes containing unstable DNA regions as candidates for disorders of motor function.
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3.
Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Nervous System Neoplasms
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
Neuralgia
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
Neurilemmoma
Mast cell and lymphoreticular infiltrates in neurofibromas. Comparison with nerve sheath tumors.
[A clinicopathologic and immunohistochemical study on 76 cases of gastrointestinal stromal tumors]
Neurobehavioral Manifestations
Plasma Biomarker for Post-concussive Syndrome: A Pilot Study Using an Alternating Current Electro-Kinetic Platform.
Neuroblastoma
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
A?1-42-mediated down-regulation of Uch-L1 is dependent on NF-?B activation and impaired BACE1 lysosomal degradation.
Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.
Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.
Comparison of the cell immunophenotype of metastatic and primary foci in stage IV-S neuroblastoma.
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Detection of neuroblastoma cells in bone marrow and peripheral blood by different techniques: accuracy and relationship with clinical features of patients.
Detection of the PGP9.5 and tyrosine hydroxylase mRNAs for minimal residual neuroblastoma cells in bone marrow and peripheral blood.
Dynamic expression of Hsp27 in the presence of mutant ataxin-3.
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma.
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells.
Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4.
Identification of evolutionary conserved regulatory sequences in the 5' untranscribed region of the neural-specific ubiquitin C-terminal hydrolase (PGP9.5) gene.
Improving Detection of Metastatic Neuroblastoma in Bone Marrow Core Biopsies: A Proposed Immunohistochemical Approach.
Low specificity of PGP9.5 expression for detection of micrometastatic neuroblastoma.
N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.
Oxidative stress regulated expression of ubiquitin Carboxyl-terminal Hydrolase-L1: role in cell survival.
Prognostic value of stage IV neuroblastoma metastatic immunophenotype in the bone marrow: preliminary report.
Protective roles of carbonic anhydrase 8 in Machado-Joseph Disease.
S-Mercuration of ubiquitin carboxyl-terminal hydrolase L1 through Cys152 by methylmercury causes inhibition of its catalytic activity and reduction of monoubiquitin levels in SH-SY5Y cells.
Sensitive detection of rare circulating neuroblastoma cells by the reverse transcriptase-polymerase chain reaction.
The deubiquitinating enzyme UCHL1 is a favorable prognostic marker in neuroblastoma as it promotes neuronal differentiation.
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells.
Ubiquitin C-terminal hydrolase-L1 (PGP9.5) expression in human neural cell lines following induction of neuronal differentiation and exposure to cytokines, neurotrophic factors or heat stress.
Ubiquitin-specific protease 22 is associated with poor prognosis in neuroblastoma.
UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein.
UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM.
USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Neurodegenerative Diseases
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.
A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.
A mitochondrial ubiquitin ligase MITOL controls cell toxicity of polyglutamine-expanded protein.
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases.
Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs.
Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.
Ataxin-3 deubiquitination is coupled to Parkin ubiquitination via E2 ubiquitin-conjugating enzyme.
Ataxin-3 is subject to autolytic cleavage.
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.
Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies.
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Behr syndrome and hypertrophic cardiomyopathy in a family with a novel UCHL1 deletion.
Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats.
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
Caffeine and adenosine A(2A) receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease.
Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.
Calpain Inhibition Is Protective in Machado-Joseph Disease Zebrafish Due to Induction of Autophagy.
Casein kinase 2 interacts with and phosphorylates ataxin-3.
cDNA cloning and tissue distribution of a rat ubiquitin carboxyl-terminal hydrolase PGP9.5.
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
Chemical chaperones reduce aggregate formation and cell death caused by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Chronic Cocaine Use Causes Changes in the Striatal Proteome Depending on the Endogenous Expression of Pleiotrophin.
Cross-over Loop Cysteine C152 Acts as an Antioxidant to Maintain the Folding Stability and Deubiquitinase Activity of UCH-L1 Under Oxidative Stress.
Decreased antioxidant enzyme activity and increased mitochondrial DNA damage in cellular models of Machado-Joseph disease.
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3.
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.
Development of Ubiquitin Variants with Selectivity for Ubiquitin C-Terminal Hydrolase Deubiquitinases.
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.
Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.
Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3.
Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease.
Expression in the mammalian retina of parkin and UCH-L1, two components of the ubiquitin-proteasome system.
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.
Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment.
Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3.
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells.
Functions of SAGA in development and disease.
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Generation of induced pluripotent stem cells from a patient with spinocerebellar ataxia type 3.
Glutathione-mediated reversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by 1,2-naphthoquinone through Cys152, but not Lys4.
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
Heterogeneous intracellular localization and expression of ataxin-3.
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Identification and functional dissection of localization signals within ataxin-3.
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Increased Cerebrospinal Fluid Levels of Ubiquitin Carboxyl-Terminal Hydrolase L1 in Patients with Alzheimer's Disease.
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease.
Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3? in a SCA3 Drosophila Model.
Lithium chloride therapy fails to improve motor function in a transgenic mouse model of Machado-Joseph disease.
Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.
Modeling the Effect of Monomer Conformational Change on the Early Stage of Protein Self-Assembly into Fibrils.
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Motor uncoordination and neuropathology in a transgenic mouse model of Machado-Joseph disease lacking intranuclear inclusions and ataxin-3 cleavage products.
Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
Natural compounds against neurodegenerative diseases: molecular characterization of the interaction of catechins from green tea with A?1-42, PrP106-126, and ataxin-3 oligomers.
Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Numerous proteins in Mammalian cells are prone to iron-dependent oxidation and proteasomal degradation.
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo.
p45, an ATPase subunit of the 19S proteasome, targets the polyglutamine disease protein ataxin-3 to the proteasome.
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Pathological ATX3 Expression Induces Cell Perturbations in E. coli as Revealed by Biochemical and Biophysical Investigations.
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Phenotyping of tianma-stimulated differentiated rat neuronal b104 cells by quantitative proteomics.
Phosphorylation of ataxin-3 by glycogen synthase kinase 3beta at serine 256 regulates the aggregation of ataxin-3.
Physiological and pathophysiological characteristics of ataxin-3 isoforms.
Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease.
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Proteasome inhibition arrests neurite outgrowth and causes "dying-back" degeneration in primary culture.
Protection against neurodegenerative disease on Earth and in space.
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Proteomic characterization of aggregating proteins after the inhibition of the ubiquitin proteasome system.
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.
Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.
RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.
Sarcolipin and ubiquitin carboxy-terminal hydrolase 1 mRNAs are over-expressed in skeletal muscles of alpha-tocopherol deficient mice.
Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice.
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Structural and functional analysis of ataxin-2 and ataxin-3.
Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1.
SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.
SUMOylation of the brain-predominant Ataxin-3 isoform modulates its interaction with p97.
Systematic Assessment of 10 Biomarker Candidates Focusing on ?-Synuclein-Related Disorders.
Temperature-dependent, irreversible formation of amyloid fibrils by a soluble human ataxin-3 carrying a moderately expanded polyglutamine stretch (Q36).
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1.
The functions of UCH-L1 and its relation to neurodegenerative diseases.
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
The josephin domain of ataxin-3 contains two distinct ubiquitin binding sites.
The Machado-Joseph disease-associated expanded form of ataxin-3: Overexpression, purification, and preliminary biophysical and structural characterization.
The point mutation UCH-L1 C152A protects primary neurons against cyclopentenone prostaglandin-induced cytotoxicity: implications for post-ischemic neuronal injury.
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity.
The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris.
The polyglutamine-expanded protein ataxin-3 decreases bcl-2 mRNA stability.
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders.
The small molecule inhibitor PR-619 protects retinal ganglion cells against glutamate excitotoxicity.
The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Ube2w and Ataxin-3 Coordinately Regulate the Ubiquitin Ligase CHIP.
Ubiquitin C-terminal hydrolase L1 interacts with choline transporter in cholinergic cells.
Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.
Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Ubiquitin Carboxyl Hydrolase L1 Significance for Human Diseases.
Ubiquitin carboxyl-terminal hydrolase (PGP 9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases.
Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?
UCHL1 from serum and CSF is a candidate biomarker for amyotrophic lateral sclerosis.
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.
Neuroectodermal Tumor, Melanotic
A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy.
Neuroectodermal Tumors
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Neuroectodermal Tumors, Primitive
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
Detection of neuroblastoma cells in blood by reverse transcriptase-polymerase chain reaction.
Protein gene product (PGP) 9.5 as a reliable marker in primitive neuroectodermal tumours--an immunohistochemical study of 21 childhood cases.
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Neuroendocrine Tumors
Decreased UCHL1 expression as a cytologic biomarker for aggressive behavior in pancreatic neuroendocrine tumors.
Paraganglioma of the cauda equina. A case report and review of the literature.
PGP 9.5, a new marker for human neuroendocrine tumours.
Prognostic relevance of UCH-L1 and ?-internexin in pancreatic neuroendocrine tumors.
Selected markers (chromogranin A, neuron-specific enolase, synaptophysin, protein gene product 9.5) in diagnosis and prognosis of neuroendocrine pulmonary tumours.
UCHL1 loss alters the cell-cycle in metastatic pancreatic neuroendocrine tumors.
Neurofibroma
Mast cell and lymphoreticular infiltrates in neurofibromas. Comparison with nerve sheath tumors.
Neurofibromatoses
Molecular pathogenesis of malignant mesothelioma.
Neurofibromatosis 2
Molecular pathogenesis of malignant mesothelioma.
Neurofibrosarcoma
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Usp9X Regulates Cell Death in Malignant Peripheral Nerve Sheath Tumors.
Neuroinflammatory Diseases
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
OTUB1 inhibits CNS autoimmunity by preventing IFN-?-induced hyperactivation of astrocytes.
Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25.
Neuroma
Neuropeptide- and tyrosine hydroxylase-immunoreactive nerve fibers in painful Morton's neuromas.
Neurothekeoma
An infiltrative variant of non-neural granular cell tumor: a case report.
Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma.
Classic neurothekeoma (nerve sheath myxoma) and cellular neurothekeoma of the oral mucosa: immunohistochemical profiles.
Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases.
Multiple desmoplastic cellular neurothekeomas localized to the face of a 16-year-old boy.
PGP9.5: a marker for cellular neurothekeoma.
Nevus, Blue
Lack of GNAQ and GNA11 Germ-Line Mutations in Familial Melanoma Pedigrees with Uveal Melanoma or Blue Nevi.
Non-alcoholic Fatty Liver Disease
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.
Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease.
Obesity
Proteomic analysis of fetal programming-related obesity markers.
The deubiquitinating enzyme USP19 modulates adipogenesis and potentiates high-fat-diet-induced obesity and glucose intolerance in mice.
Optic Atrophy
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Optic Nerve Injuries
Distribution of protein gene product 9.5 (PGP 9.5) in the vertebrate retina: evidence that immunoreactivity is restricted to mammalian horizontal and ganglion cells.
Osteoarthritis
Increased concentrations of protein gene product 9.5 in the synovial fluid from horses with osteoarthritis.
Osteoarthritis, Knee
Expression of the deubiquitinase cylindromatosis in articular cartilage and subchondral bone is associated with the severity of knee osteoarthritis.
Osteochondrosis
Increased concentrations of protein gene product 9.5 in the synovial fluid from horses with osteoarthritis.
Osteoporosis
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
Osteosarcoma
BRCA1-Associated Protein-1 Suppresses Osteosarcoma Cell Proliferation and Migration Through Regulation PI3K/Akt Pathway.
Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.
Comparative proteomic analysis of osteosarcoma cell and human primary cultured osteoblastic cell.
Downregulation of Ubiquitin-Specific Protease 22 Inhibits Proliferation, Invasion, and Epithelial-Mesenchymal Transition in Osteosarcoma Cells.
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma.
miR-140 inhibits osteosarcoma progression by impairing USP22-mediated LSD1 stabilization and promoting p21 expression.
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.
Ototoxicity
Downregulated UCHL1 Accelerates Gentamicin-Induced Auditory Cell Death via Autophagy.
Out-of-Hospital Cardiac Arrest
Ultra-early serum concentrations of neuronal and astroglial biomarkers predict poor neurological outcome after out-of-hospital cardiac arrest-a pilot neuroprognostic study.
Ovarian Neoplasms
A novel cysteine protease HeLa DUB-1 responsible for cleaving the ubiquitin in human ovarian cancer cells.
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders.
Analysis of protein profiles in human epithelial ovarian cancer tissues by proteomic technology.
Association of Promoter Methylation of VGF and PGP9.5 with Ovarian Cancer Progression.
Correction: Association of Promoter Methylation of VGF and PGP9.5 with Ovarian Cancer Progression.
Deubiquitinase PSMD14 promotes ovarian cancer progression by decreasing enzymatic activity of PKM2.
Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma.
Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer.
MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer.
OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.
Silencing of the UCHL1 gene in human colorectal and ovarian cancers.
The non-coding RNA OTUB1-isoform2 promotes ovarian tumour progression and predicts poor prognosis.
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance.
UCHL3 promotes ovarian cancer progression by stabilizing TRAF2 to activate the NF-?B pathway.
Pancreatic Neoplasms
Analysis of transcription profile to reveal altered signaling pathways following the overexpression of human desumoylating isopeptidase 2 in pancreatic cancer cells.
Clinical significance of promoter methylation status of tumor suppressor genes in circulating DNA of pancreatic cancer patients.
Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.
MicroRNA-29c Increases the Chemosensitivity of Pancreatic Cancer Cells by Inhibiting USP22 Mediated Autophagy.
PGP9.5 as a marker for invasive colorectal cancer.
PGP9.5 as a prognostic factor in pancreatic cancer.
Relationship between autophagy and perineural invasion, clinicopathological features, and prognosis in pancreatic cancer.
The deubiquitinating enzyme USP5 promotes pancreatic cancer via modulating cell cycle regulators.
Tumor Cell-Intrinsic USP22 Suppresses Antitumor Immunity in Pancreatic Cancer.
Tumor innervation and clinical outcome in pancreatic cancer.
Ubiquitin?specific protease 22?induced autophagy is correlated with poor prognosis of pancreatic cancer.
UCHL3 promotes aerobic glycolysis of pancreatic cancer through upregulating LDHA expression.
UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.
USP22 promotes epithelial-mesenchymal transition via the FAK pathway in pancreatic cancer cells.
USP44 suppresses pancreatic cancer progression and overcomes gemcitabine resistance by deubiquitinating FBP1.
Pancreatitis, Chronic
Clinical significance of promoter methylation status of tumor suppressor genes in circulating DNA of pancreatic cancer patients.
Paralysis
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia.
Parathyroid Neoplasms
Accuracy of combined protein gene product 9.5 and parafibromin markers for immunohistochemical diagnosis of parathyroid carcinoma.
Parafibromin, Galectin-3, PGP9.5, Ki67, and Cyclin D1: Using an Immunohistochemical Panel to Aid in the Diagnosis of Parathyroid Cancer.
Parathyroid carcinoma: current understanding and new insights into gene expression and intraoperative parathyroid hormone kinetics.
Parkinson Disease
A cysteine near the C-terminus of UCH-L1 is dispensable for catalytic activity but is required to promote AKT phosphorylation, eIF4F assembly, and malignant B-cell survival.
A polymorphic variation of serine to tyrosine at codon 18 in the ubiquitin C-terminal hydrolase-L1 gene is associated with a reduced risk of sporadic Parkinson's disease in a Japanese population.
ACT and UCH-L1 polymorphisms in Parkinson's disease and age of onset.
Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants.
Amyloid aggregates of the deubiquitinase OTUB1 are neurotoxic, suggesting that they contribute to the development of Parkinson's disease.
An Ile93Met substitution in the UCH-L1 gene is not a disease-causing mutation for idiopathic Parkinson's disease.
Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.
Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene and sporadic Parkinson's disease.
Association Between the Ubiquitin Carboxyl-Terminal Esterase L1 Gene (UCHL1) S18Y Variant and Parkinson's Disease: A HuGE Review and Meta-Analysis.
Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.
Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms.
Association study of DNAJC13, UCHL1, HTRA2, GIGYF2, and EIF4G1 with Parkinson's disease.
Backbone and side-chain (1)H, (15)N and (13)C resonance assignments of S18Y mutant of ubiquitin carboxy-terminal hydrolase L1.
Backbone assignments of the 26 kDa neuron-specific ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1).
Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.
Case-control study of the UCH-L1 S18Y variant in sporadic Parkinson's disease in the Chinese population.
Case-control study of UCHL1 S18Y variant in Parkinson's disease.
Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering.
Chronic Cocaine Use Causes Changes in the Striatal Proteome Depending on the Endogenous Expression of Pleiotrophin.
Citrate-capped gold nanoparticles for the label-free detection of ubiquitin C-terminal hydrolase-1.
Cloning and expression analysis of a Parkinson's disease gene, uch-L1, and its promoter in zebrafish.
Complex interactions in Parkinson's disease: a two-phased approach.
CSF ?-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.
Cutaneous Alpha-Synuclein is Correlated with Autonomic Impairment in Isolated REM Sleep Behavior Disorder.
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1.
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.
Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease.
Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.
Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.
Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor.
Excess ?-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1.
Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease.
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease.
Failure to find mutations in ubiquitin carboxy-terminal hydrolase L1 gene in familial Parkinson's disease.
Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders.
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.
Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.
Genetic causes of Parkinson's disease: UCHL-1.
Genetics and Parkinson's disease.
Genetics of Parkinson's disease.
Identification of tyrosine nitration in UCH-L1 and GAPDH.
Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures.
Improving synaptic function in a mouse model of AD.
Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents ?-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy.
Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy.
Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation.
Lack of association between UCHL1 S18Y gene polymorphism and Parkinson's disease in the Asian population: a meta-analysis.
Lack of Association of the UCHL-1 gene with Parkinson's disease in a greek cohort: A haplotype-tagging approach.
Lack of evidence for an association between UCHL1 S18Y and Parkinson's disease.
Lack of evidence for association of a UCH-L1 S18Y polymorphism with Parkinson's disease in a Han-Chinese population.
Lack of genetic association of the UCHL1 gene with Alzheimer's disease and Parkinson's disease with dementia.
Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis.
Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease.
Lrrk2 and alpha-synuclein are co-regulated in rodent striatum.
Mechanistic studies of ubiquitin C-terminal hydrolase l1.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways.
Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.
Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.
Mutation analysis of LRRK2, SCNA, UCHL1, HtrA2 and GIGYF2 genes in Chinese patients with autosomal dorminant Parkinson's disease.
N-terminal truncated UCH-L1 prevents Parkinson's disease associated damage.
NF-?B signaling inhibits ubiquitin carboxyl-terminal hydrolase L1 gene expression.
No genetic association of the ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism with familial Parkinson's disease.
Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system.
Parkinson's disease-associated mutations in ?-synuclein and UCH-L1 inhibit the unconventional secretion of UCH-L1.
Parkinson's genetics--creating exciting new insights.
Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson's disease.
Porcine UCHL1: genomic organization, chromosome localization and expression analysis.
Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma.
Production of polyclonal anti-dUCH (Drosophila Ubiquitin Carboxyl-terminal Hydrolase) antibodies.
Progress in familial Parkinson's disease.
Protective and toxic roles of dopamine in Parkinson's disease.
Proteomic identification of dopamine-conjugated proteins from isolated rat brain mitochondria and SH-SY5Y cells.
Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1.
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
S-nitrosylation of UCHL1 induces its structural instability and promotes ?-synuclein aggregation.
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden.
S18Y polymorphism in the UCH-L1 gene and Parkinson's disease: evidence for an age-dependent relationship.
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Substrate recognition and catalysis by UCH-L1.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK).
The Effect of Parkinson's-Disease-Associated Mutations on the Deubiquitinating Enzyme UCH-L1.
The G2019S LRRK2 mutation is rare in Korean patients with Parkinson's disease.
The Knotted Protein UCH-L1 Exhibits Partially Unfolded Forms under Native Conditions that Share Common Structural Features with Its Kinetic Folding Intermediates.
The long non-coding RNAs in neurodegenerative diseases: novel mechanisms of pathogenesis.
The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability.
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells.
The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons.
The ubiquitin carboxy-terminal hydrolase-L1 gene S18Y polymorphism does not confer protection against idiopathic Parkinson's disease.
The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.
The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population.
Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity.
Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease.
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron.
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation.
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.
UCH-L1 S18Y variant and risk of Parkinson's disease in Asian populations: an updated meta-analysis.
UCHL-1 gene in multiple system atrophy: a haplotype tagging approach.
UCHL-1 is not a Parkinson's disease susceptibility gene.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein.
UCHL1 is a Parkinson's disease susceptibility gene.
UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study.
UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan.
[Association of the ubiquitin carboxy-terminal hydrolase-L1 genetic polymorphism with the susceptibility of Parkinson's disease.]
[Association of two polymorphisms in ubiquitin carboxy-terminal hydrolase-L1 gene with Parkinson's disease in Shanghai]
[Parkinson's disease: what have we learned from the genes responsible for familial forms?]
[The ubiquitin-proteasome system and neurodegeneration]
Parkinsonian Disorders
Analysis of alpha-synuclein, parkin, tau, and UCH-L1 in a Japanese family with autosomal dominant parkinsonism.
CSF ?-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.
Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function.
New endemic familial parkinsonism in south Moravia, Czech Republic and its genetical background.
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease.
[Parkinson's disease: what have we learned from the genes responsible for familial forms?]
[The genetics of Parkinson syndrome]
Periodontitis
Comparison of NK-cell (Leu-7+ and Leu-11b+) populations in clinically healthy gingiva, chronic gingivitis and chronic adult periodontitis.
Peripheral Nervous System Diseases
Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases.
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy.
Trench Foot or Non-Freezing Cold Injury As a Painful Vaso-Neuropathy: Clinical and Skin Biopsy Assessments.
Pheochromocytoma
Disseminated pheochromocytoma in a North American river otter (Lontra canadensis).
Phyllodes Tumor
Ubiquitin carboxy-terminal hydrolase L1 may be involved in the development of mammary phyllodes tumors.
Pinealoma
Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors.
Pituitary Neoplasms
Protein gene product (PGP) 9.5 in diagnostic (neuro-) oncology. An immunomorphological study.
Pneumonia
The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
Pneumothorax
Familial spontaneous pneumothorax and Machado-Joseph disease.
Polyneuropathies
Pain-related changes in cutaneous innervation of patients suffering from bortezomib-induced, diabetic or chronic idiopathic axonal polyneuropathy.
Porcine Reproductive and Respiratory Syndrome
Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunophenotypic analysis of acute lymphoblastic leukemia using routinely processed bone marrow specimens.
New marker of B lymphocytes, MB2: comparison with other lymphocyte subset markers active in conventionally processed tissue sections.
Role of ubiquitin carboxyl terminal hydrolase in the differentiation of human acute lymphoblastic leukemia cell line, Reh.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Overexpression of Ubiquitin Specific Protease 44 (USP44) Induces Chromosomal Instability and Is Frequently Observed in Human T-Cell Leukemia.
Prostatic Hyperplasia
OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1.
Prostatic Neoplasms
Clinicopathological significance of ubiquitin-specific protease 2a (USP2a), fatty acid synthase (FASN), and ErbB2 expression in oral squamous cell carcinomas.
Deubiquitinating enzyme USP33 restrains docetaxel-induced apoptosis via stabilising the phosphatase DUSP1 in prostate cancer.
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A.
Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells.
Localization of protein gene product 9.5 immunoreactivity in derivatives of the human Wolffian duct and in prostate cancer.
Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo.
OTUB1 Promotes Progression and Proliferation of Prostate Cancer via Deubiquitinating and Stabling Cyclin E1.
Survey of differentially methylated promoters in prostate cancer cell lines.
The Deubiquitinating Enzyme USP7 Regulates Androgen Receptor Activity by Modulating Its Binding to Chromatin.
The Isopeptidase USP2a Protects Human Prostate Cancer from Apoptosis.
The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer.
The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.
The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-?/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer.
Tumor Suppressor Function of PGP9.5 Is Associated with Epigenetic Regulation in Prostate Cancer--Novel Predictor of Biochemical Recurrence after Radical Surgery.
Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines.
Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation.
UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction.
USP22 Functions as an Oncogenic Driver in Prostate Cancer by Regulating Cell Proliferation and DNA Repair.
USP2a activation of MYC in prostate cancer.
USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization.
Proteinuria
Autoantibodies against podocytic UCHL1 are associated with idiopathic nephrotic syndrome relapses and induce proteinuria in mice.
The regulation of the UCH-L1 gene by transcription factor NF-?B in podocytes.
Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.
Prurigo
Eosinophil cationic protein- and eosinophil-derived neurotoxin/eosinophil protein X-immunoreactive eosinophils in prurigo nodularis.
Pseudolymphoma
Formalin-resistant leukocyte surface antigens in the diagnosis of cutaneous malignant lymphomas.
Immunohistochemical differential diagnosis between lymphocytoma cutis and malignant lymphoma in paraffin-embedded sections.
Psoriasis
Dithranol abolishes UCH-L1 immunoreactivity in the nerve fibers of the rat orofacial skin.
Expression of Neuropeptides, Neurotrophins, and Neurotransmitters in the Skin of Patients with Atopic Dermatitis and Psoriasis.
[Role of the skin expression of neuropeptides, neurotrophins and their receptors in the pathogenesis of dermatoses].
Pulmonary Disease, Chronic Obstructive
Long non-coding RNA expression patterns in lung tissues of chronic cigarette smoke induced COPD mouse model.
OTUB1 Recruits Tumor Infiltrating Lymphocytes and Is a Prognostic Marker in Digestive Cancers.
Pulmonary Fibrosis
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGF?-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis.
Rabies
Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.
Rectal Neoplasms
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
UCHL5 expression associates with improved survival in lymph-node-positive rectal cancer.
Reperfusion Injury
Knockdown EZH2 attenuates cerebral ischemia-reperfusion injury via regulating microRNA-30d-3p methylation and USP22.
USP22 Protects Against Myocardial Ischemia-Reperfusion Injury via the SIRT1-p53/SLC7A11-Dependent Inhibition of Ferroptosis-Induced Cardiomyocyte Death.
Retinal Degeneration
Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice.
Retinal Detachment
RNA Interference Reveals the Coregulatory Effects of Cylindromatosis on Apoptosis and Necroptosis of Photoreceptor Cells in Experimental Retinal Detachment.
Retinal Diseases
UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2.
Retinoblastoma
Disseminated retinoblastoma successfully treated with myeloablative chemotherapy--implication for molecular detection of minimal residual disease.
microRNA-362-3p targets USP22 to retard retinoblastoma growth via reducing deubiquitination of LSD1.
PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours.
Role of ubiquitin-specific peptidase 22 in carcinogenesis of human pharyngeal squamous cell carcinoma.
The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein.
The double dealing of cyclin D1.
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease.
USP22 down-regulation facilitates human retinoblastoma cell aging and apoptosis via inhibiting TERT/P53 pathway.
Rhabdomyolysis
Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.
Rhabdomyosarcoma
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
Rhabdomyosarcoma, Alveolar
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Rhabdomyosarcoma, Embryonal
Expression of protein gene product 9.5 and tyrosine hydroxylase in childhood small round cell tumors.
Rhinitis
Neuronal markers in allergic rhinitis: expression and correlation with sensory testing.
Rubella
Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses.
Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses.
Salivary Gland Neoplasms
DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Salmonella Infections
Activity-Based Proteomic Profiling of Deubiquitinating Enzymes in Salmonella-Infected Macrophages Leads to Identification of Putative Function of UCH-L5 in Inflammasome Regulation.
Sandhoff Disease
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Sarcoma
A comparative study of immunohistochemical staining for neuron-specific enolase, protein gene product 9.5 and S-100 protein in neuroblastoma, Ewing's sarcoma and other round cell tumours in children.
Classification of Canine Nonangiogenic, Nonlymphogenic, Gastrointestinal Sarcomas Based on Microscopic, Immunohistochemical, and Molecular Characteristics.
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.
Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks.
Sarcoma, Ewing
Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors.
USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth.
Sarcoma, Kaposi
PGP 9.5 neuronal marker may differentiate immunohistochemically HIV-related from Mediterranean and immunosuppression-associated Kaposi's sarcoma.
Sarcoma, Myeloid
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues.
Sarcoma, Synovial
Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors.
Scleroderma, Systemic
Deficiency of calcitonin gene-related peptide in Raynaud's phenomenon.
Seizures
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.
Correction to: Circulating glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase-L1 as markers of neuronal damage in children with epileptic seizures.
Evaluation of ubiquitin C-terminal hydrolase-L1 enzyme levels in patients with epilepsy.
First Replication of the Involvement of OTUD6B in Intellectual Disability Syndrome With Seizures and Dysmorphic Features.
Pro-inflammatory cytokines, but not brain- and extracellular matrix-derived proteins, are increased in the plasma following electrically induced kindling of seizures.
Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.
The diagnostic value of serum UCHL-1 and S100-B levels in differentiate epileptic seizures from psychogenic attacks.
The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure.
UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model.
Seminoma
Expression of Protein Gene Product 9.5 and Sal-like Protein 4 in Canine Seminomas.
Statistical considerations in the methodology of quantifying immunocompetent cells in tumors.
Sepsis
Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication.
Sepsis-Associated Encephalopathy
Serum glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 for diagnosis of sepsis-associated encephalopathy and outcome prognostication.
Severe Acute Respiratory Syndrome
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
A multifactorial score including autophagy for prognosis and care of COVID-19 patients.
A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.
Binding site-based classification of coronaviral papain-like proteases.
Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.
Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV.
Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities.
Chemical constituents from coconut waste and their in silico evaluation as potential antiviral agents against SARS-CoV-2.
Coronavirus interactions with the cellular autophagy machinery.
Crystal structure of SARS-CoV-2 papain-like protease.
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression.
Diarylheptanoids from Alnus japonica Inhibit Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus.
Differential domain structure stability of the severe acute respiratory syndrome coronavirus papain-like protease.
Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches.
Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity.
In search of drugs to alleviate suppression of the host's innate immune responses against SARS-CoV-2 using a molecular modeling approach.
Is oseltamivir suitable for fighting against COVID-19: In silico assessment, in vitro and retrospective study.
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
Molecular Dynamic Studies of Interferon and Innate Immunity Resistance in MERS CoV Non-Structural Protein 3.
Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.
Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities.
Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits.
Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
Phytochemical profile of Paulownia tomentosa (Thunb). Steud.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes).
Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.
Regulation of IRF-3-dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus.
SARS Coronavirus Papain-Like Protease Inhibits the TLR7 Signaling Pathway through Removing Lys63-Linked Polyubiquitination of TRAF3 and TRAF6.
SARS-CoV-2 Papain-Like Protease Potential Inhibitors-In Silico Quantitative Assessment.
Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease.
Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme.
Structural basis for catalysis and ubiquitin recognition by the severe acute respiratory syndrome coronavirus papain-like protease.
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease.
Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus.
Synergistic inhibitor binding to the papain-like protease of human SARS coronavirus: mechanistic and inhibitor design implications.
The emerging SARS-CoV-2 papain-like protease: Its relationship with recent coronavirus epidemics.
The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase.
The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme.
The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.
Thiopurine analogue inhibitors of severe acute respiratory syndrome-coronavirus papain-like protease, a deubiquitinating and deISGylating enzyme.
Thiopurine analogues inhibit papain-like protease of severe acute respiratory syndrome coronavirus.
Sex Cord-Gonadal Stromal Tumors
Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog.
Skin Diseases
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Skin Neoplasms
Pgp 9.5 and Cyclin D1 Co-Expression in Cutaneous Squamous Cell Carcinomas.
PGP 9.5 expression in cutaneous keratoacanthomas and squamous cell carcinomas.
Small Cell Lung Carcinoma
Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.
Small Fiber Neuropathy
Automated PGP9.5 immunofluorescence staining: a valuable tool in the assessment of small fiber neuropathy?
Soft Tissue Neoplasms
Protein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma.
Spinal Cord Compression
Expression of the ubiquitin carboxyl-terminal hydrolase PGP 9.5 in axons following spinal cord compression trauma. An immunohistochemical study in the rat.
Systemic hypothermia following spinal cord compression injury in the rat: axonal changes studied by beta-APP, ubiquitin, and PGP 9.5 immunohistochemistry.
Spinal Cord Diseases
[An autopsy case with subacute spinal cord disease showing progressive paraplegia]
Spinal Cord Injuries
Accumulation of immunoreactivity to ubiquitin carboxyl-terminal hydrolase PGP 9.5 in axons of human cases with spinal cord lesions.
Characterization of Cerebrospinal Fluid Ubiquitin C-Terminal Hydrolase L1 as a Biomarker of Human Acute Traumatic Spinal Cord Injury.
Single-step functionalization of poly-catecholamine nanofilms for ultra-sensitive immunosensing of ubiquitin carboxyl terminal hydrolase-L1 (UCHL-1) in spinal cord injury.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Spinocerebellar Ataxias
A hydrophobic gold surface triggers misfolding and aggregation of the amyloidogenic josephin domain in monomeric form, while leaving the oligomers unaffected.
A major role for side-chain polyglutamine hydrogen bonding in irreversible ataxin-3 aggregation.
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
A new role for microRNA pathways: modulation of degeneration induced by pathogenic human disease proteins.
A spinocerebellar ataxia family with expanded alleles in the tata-binding protein gene and ataxin-3 gene.
A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3.
A transgenic mouse model of spinocerebellar ataxia type 3 resembling late disease onset and gender-specific instability of CAG repeats.
Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117.
Allosteric regulation of deubiquitylase activity through ubiquitination.
Altered Expression of Carbonic Anhydrase-Related Protein XI in Neuronal Cells Expressing Mutant Ataxin-3.
An expanded glutamine repeat destabilizes native ataxin-3 structure and mediates formation of parallel beta -fibrils.
Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease.
Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.
Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates.
Ataxin-3 is subject to autolytic cleavage.
Ataxin-3 phosphorylation decreases neuronal defects in spinocerebellar ataxia type 3 models.
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.
Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies.
Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: Removal of the CAG containing exon.
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation.
Autophagy induction reduces mutant ataxin-3 levels and toxicity in a mouse model of spinocerebellar ataxia type 3.
Axonal inclusions in spinocerebellar ataxia type 3.
Brain stem and cerebellum volumetric analysis of Machado Joseph disease patients.
Broad Influence of Mutant Ataxin-3 on the Proteome of the Adult Brain, Young Neurons, and Axons Reveals Central Molecular Processes and Biomarkers in SCA3/MJD Using Knock-In Mouse Model.
Broadening the therapeutic scope for rapamycin treatment.
Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.
Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
Capturing the Conformational Ensemble of the Mixed Folded Polyglutamine Protein Ataxin-3.
Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.
Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity.
Cerebellar soluble mutant ataxin-3 level decreases during disease progression in Spinocerebellar Ataxia Type 3 mice.
Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3.
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3.
Clinical features and genetic diagnosis of hereditary spinocerebellar ataxia 3.
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7.
CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Degron capability of the hydrophobic C-terminus of the polyglutamine disease protein, ataxin-3.
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.
Destabilization of non-pathological variants of ataxin-3 by metal ions results in aggregation/fibrillogenesis.
Differential toxicity of ataxin-3 isoforms in Drosophila models of Spinocerebellar Ataxia Type 3.
Disulfiram facilitates ataxin-3 nuclear translocation and potentiates the cytotoxicity in a cell model of SCA3.
Divalproex sodium regulates ataxin-3 translocation likely by an importin ?1-dependent pathway.
Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail.
Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia type 3 disease protein.
Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.
Epigallocatechin-3-gallate and tetracycline differently affect ataxin-3 fibrillogenesis and reduce toxicity in spinocerebellar ataxia type 3 model.
Experimental and Clinical Strategies for Treating Spinocerebellar Ataxia Type 3.
FOXO4-dependent upregulation of superoxide dismutase-2 in response to oxidative stress is impaired in spinocerebellar ataxia type 3.
Functional interactions as a survival strategy against abnormal aggregation.
Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3.
Generation of induced pluripotent stem cell line (ZZUi0026-A) from a patient with spinocerebellar ataxia type 3.
Generation of induced pluripotent stem cells from a patient with spinocerebellar ataxia type 3.
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
HDAC inhibitor sodium butyrate reverses transcriptional downregulation and ameliorates ataxic symptoms in a transgenic mouse model of SCA3.
Heterogeneous intracellular localization and expression of ataxin-3.
How Epigallocatechin-3-gallate and Tetracycline Interact with the Josephin Domain of Ataxin-3 and Alter Its Aggregation Mode.
Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models.
Identification and functional dissection of localization signals within ataxin-3.
Identification of the calpain-generated toxic fragment of ataxin-3 protein provides new avenues for therapy of Machado-Joseph disease| Spinocerebellar ataxia type 3.
In vivo suppression of polyglutamine neurotoxicity by C-terminus of Hsp70-interacting protein (CHIP) supports an aggregation model of pathogenesis.
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination.
Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains.
Interaction of the polyglutamine protein ataxin-3 with Rad23 regulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3.
Interactions of ataxin-3 with its molecular partners in the protein machinery that sorts protein aggregates to the aggresome.
Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Karyopherin ?-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
Lithium carbonate and coenzyme Q10 reduce cell death in a cell model of Machado-Joseph disease.
Lithium Chloride Alleviates Neurodegeneration Partly by Inhibiting Activity of GSK3? in a SCA3 Drosophila Model.
Loss of the Spinocerebellar Ataxia type 3 disease protein ATXN3 alters transcription of multiple signal transduction pathways.
Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.
Mechanisms of ataxin-3 misfolding and fibril formation: kinetic analysis of a disease-associated polyglutamine protein.
Modeling the Effect of Monomer Conformational Change on the Early Stage of Protein Self-Assembly into Fibrils.
Molecular clearance of ataxin-3 is regulated by a mammalian E4.
Mouse models of Machado-Joseph disease and other polyglutamine spinocerebellar ataxias.
Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).
Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells.
Mutant Ataxin-3-Containing Aggregates (MATAGGs) in Spinocerebellar Ataxia Type 3: Dynamics of the Disorder.
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway.
N-terminal ataxin-3 causes neurological symptoms with inclusions, endoplasmic reticulum stress and ribosomal dislocation.
Neurodegenerative phosphoprotein signaling landscape in models of SCA3.
Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease.
Non-expanded polyglutamine proteins in intranuclear inclusions of hereditary ataxias--triple-labeling immunofluorescence study.
Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease.
Nuclear aggregation of polyglutamine-expanded ataxin-3: fragments escape the cytoplasmic quality control.
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Overexpression of Mutant Ataxin-3 in Mouse Cerebellum Induces Ataxia and Cerebellar Neuropathology.
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease.
p53 activation mediates polyglutamine-expanded ataxin-3 upregulation of Bax expression in cerebellar and pontine nuclei neurons.
Pathological ATX3 Expression Induces Cell Perturbations in E. coli as Revealed by Biochemical and Biophysical Investigations.
Polyglutamine diseases: The special case of ataxin-3 and Machado-Joseph disease.
Polyglutamine expansion of ataxin-3 alters its degree of ubiquitination and phosphorylation at specific sites.
Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.
Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood.
PolyQ-expanded ataxin-3 interacts with full-length ataxin-3 in a polyQ length-dependent manner.
Potassium channel dysfunction and depolarized resting membrane potential in a cell model of SCA3.
Preventing Ataxin-3 protein cleavage mitigates degeneration in a Drosophila model of SCA-3.
Proteomic and biochemical analyses unveil tight interaction of ataxin-3 with tubulin.
Proteotoxic stress increases nuclear localization of ataxin-3.
RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context.
Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation.
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.
Research on screening and identification of proteins interacting with ataxin-3.
Reversibility of symptoms in a conditional mouse model of Spinocerebellar Ataxia Type 3.
RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease.
RNA toxicity is a component of ataxin-3 degeneration in Drosophila.
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
SCA3: Neurological features, pathogenesis and animal models.
Schwann cell involvement in the peripheral neuropathy of spinocerebellar ataxia type 3.
Silencing Mutant ATXN3 Expression Resolves Molecular Phenotypes in SCA3 Transgenic Mice.
Spinocerebellar Ataxia Type 3 (SCA3): Thalamic Neurodegeneration Occurs Independently from Thalamic Ataxin-3 Immunopositive Neuronal Intranuclear Inclusions.
Spinocerebellar ataxia type 3 in Israel: phenotype and genotype of a Jew Yemenite subpopulation.
Structural and functional analysis of ataxin-2 and ataxin-3.
Structural modeling of ataxin-3 reveals distant homology to adaptins.
Structure validation of the Josephin domain of ataxin-3: conclusive evidence for an open conformation.
Study of subcellular localization and proteolysis of ataxin-3.
SUMO-1 modification on K166 of polyQ-expanded ataxin-3 strengthens its stability and increases its cytotoxicity.
Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide.
Suppression of polyglutamine toxicity by the yeast Sup35 prion domain in Drosophila.
T1-11 and JMF1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration, transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.
Targeting several CAG expansion diseases by a single antisense oligonucleotide.
Temperature profoundly affects ataxin-3 fibrillogenesis.
The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3.
The autophagy-enhancing drug carbamazepine improves neuropathology and motor impairment in mouse models of Machado-Joseph disease.
The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples.
The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila melanogaster.
The Josephin domain determines the morphological and mechanical properties of ataxin-3 fibrils.
The Machado-Joseph Disease Deubiquitinase Ataxin-3 Regulates the Stability and Apoptotic Function of p53.
The Machado-Joseph disease deubiquitylase ataxin-3 interacts with LC3C/GABARAP and promotes autophagy.
The relationship between aggregation and toxicity of polyglutamine-containing ataxin-3 in the intracellular environment of Escherichia coli.
The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease.
The role of the central flexible region on the aggregation and conformational properties of human ataxin-3.
The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis.
The Toxic Effects of Pathogenic Ataxin-3 Variants in a Yeast Cellular Model.
The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.
Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3.
Toward therapeutic targets for SCA3: Insight into the role of Machado-Joseph disease protein ataxin-3 in misfolded proteins clearance.
Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model.
Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3.
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models.
Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23.
Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
UCHL3 Regulates Topoisomerase-Induced Chromosomal Break Repair by Controlling TDP1 Proteostasis.
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3.
Upregulation of miR-25 and miR-181 Family Members Correlates with Reduced Expression of ATXN3 in Lymphocytes from SCA3 Patients.
Upregulation of miR-370 and miR-543 is associated with reduced expression of heat shock protein 40 in spinocerebellar ataxia type 3.
Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.
Valosin-Containing Protein (VCP/p97) Is an Activator of Wild-Type Ataxin-3.
Vulnerability of frontal brain neurons for the toxicity of expanded ataxin-3.
[Screening for proteins interacting with ataxin-3, the gene product of SCA3/MJD]
Spinocerebellar Degenerations
Decreased protein synthesis of Hsp27 associated with cellular toxicity in a cell model of Machado-Joseph disease.
Squamous Cell Carcinoma of Head and Neck
Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness.
Expression of USP22 and the chromosomal passenger complex is an indicator of malignant progression in oral squamous cell carcinoma.
Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells.
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
Regulation of Oral Squamous Cell Carcinoma Proliferation Through Crosstalk Between SMAD7 and CYLD.
The role of PGP9.5 as a tumor suppressor gene in human cancer.
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma.
USP22 Is Useful as a Novel Molecular Marker for Predicting Disease Progression and Patient Prognosis of Oral Squamous Cell Carcinoma.
[Expression of cancer stem cell marker USP22 in laryngeal squamous cell carcinoma].
Starvation
A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium.
Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.
Expression of protein gene product 9.5 (PGP9.5)/ubiquitin-C-terminal hydrolase 1 (UCHL-1) in human myeloma cells.
Status Epilepticus
Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury.
Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure.
Stomach Neoplasms
Ataxin-3 expression correlates with the clinicopathologic features of gastric cancer.
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Correction: Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Deubiquitinating enzyme USP20 is a positive regulator of Claspin and suppresses the malignant characteristics of gastric cancer cells.
Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.
Filtering High-Dimensional Methylation Marks With Extremely Small Sample Size: An Application to Gastric Cancer Data.
Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P.
High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer.
Is co-expression of USP22 and HSP90 more effective in predicting prognosis of gastric cancer?
LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5.
Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling.
OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.
PGP9.5 methylation in diffuse-type gastric cancer.
PGP9.5 overexpression in esophageal squamous cell carcinoma.
PGP9.5 was less frequently methylated in advanced gastric carcinoma.
Positive cytoplasmic UCHL5 tumor expression in gastric cancer is linked to improved prognosis.
Targeted eradication of gastric cancer stem cells by CD44 targeting USP22 small interfering RNA-loaded nanoliposomes.
The de-ubiquitinase UCHL1 promotes gastric cancer metastasis via the Akt and Erk1/2 pathways.
The diagnosis value of promoter methylation of UCHL1 in the serum for progression of gastric cancer.
Ubiquitin-specific peptidase 22 overexpression may promote cancer progression and poor prognosis in human gastric carcinoma.
Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner.
UCH-LI acts as a novel prognostic biomarker in gastric cardiac adenocarcinoma.
UCHL3 stimulates metastasis of gastric cancer through upregulating IGF2.
USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer.
USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein.
Strabismus
CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
Stroke
Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients.
Biomarkers for acute diagnosis and management of stroke in neurointensive care units.
Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1).
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia.
Modification of ubiquitin-C-terminal hydrolase-L1 by cyclopentenone prostaglandins exacerbates hypoxic injury.
Quantitative neuroproteomics of an in vivo rodent model of focal cerebral ischemia/reperfusion injury reveals a temporal regulation of novel pathophysiological molecular markers.
Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Stroke and Amyloid-? Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response.
Treatment efficacy of arterial urokinase thrombolysis combined with mechanical thrombectomy for acute cerebral infarction and its influence on neuroprotective factors and factors for neurological injury.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Subarachnoid Hemorrhage
A Pilot Study of Novel biomarkers in neonates with Hypoxic-Ischemic Encephalopathy.
Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure.
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning.
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage.
Increased plasma UCH-L1 after aneurysmal subarachnoid hemorrhage is associated with unfavorable neurological outcome.
Synucleinopathies
Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.
DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.
Tauopathies
Role of autophagy in the clearance of mutant huntingtin: a step towards therapy?
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.
Tendinopathy
Is vasculo-neural ingrowth the cause of pain in chronic Achilles tendinosis? An investigation using ultrasonography and colour Doppler, immunohistochemistry, and diagnostic injections.
The innervation pattern of the human Achilles tendon: studies of the normal and tendinosis tendon with markers for general and sensory innervation.
Teratoma
Statistical considerations in the methodology of quantifying immunocompetent cells in tumors.
Testicular Neoplasms
Ataxin-3 promotes testicular cancer cell proliferation by inhibiting anti-oncogene PTEN.
Thrombosis
Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech.
Thyroid Cancer, Papillary
Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion.
MiR-101 targets USP22 to inhibit the tumorigenesis of papillary thyroid carcinoma.
miR-29a-3p inhibits growth, proliferation, and invasion of papillary thyroid carcinoma by suppressing NF-?B signaling via direct targeting of OTUB2.
Prognostic significance of USP22 as an oncogene in papillary thyroid carcinoma.
Thyroid Carcinoma, Anaplastic
Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma.
The deubiquitinating enzyme ATXN3 promotes the progression of anaplastic thyroid carcinoma by stabilizing EIF5A2.
Thyroid Neoplasms
A putative OTU domain-containing protein 1 deubiquitinating enzyme is differentially expressed in thyroid cancer and identifies less-aggressive tumours.
Innervation of papillary thyroid cancer and its association with extra-thyroidal invasion.
PGP9.5 mRNA could contribute to the molecular-based diagnosis of medullary thyroid carcinoma.
Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration.
Trauma, Nervous System
Biomarker evidence for mild central nervous system injury after surgically-induced circulation arrest.
Tremor
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence.
Peripheral neuropathy and parkinsonism: a large clinical and pathogenic spectrum.
Triple Negative Breast Neoplasms
USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.
Trophoblastic Neoplasms
Immunohistochemistry of germ cell and trophoblastic neoplasms.
Tuberculosis
Deciphering Molecular Virulence Mechanism of Mycobacterium tuberculosis Dop isopeptidase Based on Its Sequence-Structure-Function Linkage.
ubiquitinyl hydrolase 1 deficiency
Accumulation of beta- and gamma-synucleins in the ubiquitin carboxyl-terminal hydrolase L1-deficient gad mouse.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
BETA-CELL DYSFUNCTIONAL ERAD/UBIQUITIN/PROTEASOME SYSTEM IN TYPE 2 DIABETES MEDIATED BY IAPP-INDUCED UCH-L1 DEFICIENCY.
Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice.
Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.
Effects of ubiquitin C-terminal hydrolase-L1 deficiency on mouse ova.
Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development.
Loss of UCHL1 rescues the defects related to Parkinson's disease by suppressing glycolysis.
Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways.
Preventing abnormal NF-?B activation and autoimmunity by Otub1-mediated p100 stabilization.
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination.
The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Ubiquitin C-terminal hydrolase L1 deficiency decreases bone mineralization.
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in ?-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy.
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
USP19 Inhibits TNF-?- and IL-1?-Triggered NF-?B Activation by Deubiquitinating TAK1.
USP22 controls iNKT immunity through MED1 suppression of histone H2A monoubiquitination.
Usp22 deficiency impairs intestinal epithelial lineage specification in vivo.
USP22 deficiency in melanoma mediates resistance to T cells through IFN?-JAK1-STAT1 signal axis.
USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism.
USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
Urinary Bladder Neoplasms
An 18-gene signature based on glucose metabolism and DNA methylation improves prognostic prediction for urinary bladder cancer.
Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis.
MINDY1 promotes bladder cancer progression by stabilizing YAP.
OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress.
Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells.
Urinary Bladder, Overactive
Sensory hyperinnervation distinguishes bladder pain syndrome/interstitial cystitis from overactive bladder syndrome.
Uterine Cervical Neoplasms
Identification of potential target genes of USP22 via ChIP-seq and RNA-seq analysis in HeLa cells.
miR-31 Functions as an Oncomir Which Promotes Epithelial-Mesenchymal Transition via Regulating BAP1 in Cervical Cancer.
Ubiquitin-specific protease 22: a novel molecular biomarker in cervical cancer prognosis and therapeutics.
Vascular Diseases
Cezanne is a critical regulator of pathological arterial remodelling by targeting ?-catenin signalling.
The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for A? 42 Accumulation in Alzheimer's and Vascular Disease.
Ventilator-Induced Lung Injury
UCHL1, a Deubiquitinating Enzyme, Regulates Lung Endothelial Cell Permeability In Vitro and In Vivo.
Vesicular Stomatitis
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Virus Diseases
A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses.
HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1.
Knockout of Epstein-Barr virus BPLF1 retards B-cell transformation and lymphoma formation in humanized mice.
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
MERS-CoV papain-like protease has deISGylating and deubiquitinating activities.
Meticulous assessment of natural compounds from NPASS database for identifying analogue of GRL0617, the only known inhibitor for SARS-CoV2 papain-like protease (PLpro) using rigorous computational workflow.
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2.
USP7 manipulation by viral proteins.
X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.
Vitiligo
Neuropeptide and neuronal marker studies in vitiligo.
Vulvodynia
Increased innervation of the vulval vestibule in patients with vulvodynia.
Waldenstrom Macroglobulinemia
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells.