Disease on EC 3.4.18.1 - cathepsin X
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Acquired Immunodeficiency Syndrome
The function of cathepsins B, D, and X in atherosclerosis.
Adenocarcinoma
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia.
Alagille Syndrome
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.
Alzheimer Disease
Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1?E9 Transgenic Mice Implicate Cathepsin Z in Alzheimer's Disease.
Alzheimer Disease
Neuroprotective role of ?-enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X.
Breast Neoplasms
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Carcinogenesis
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.
Carcinogenesis
IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells.
Carcinogenesis
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Carcinogenesis
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia.
Carcinoma
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Carcinoma
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia.
Carcinoma, Hepatocellular
Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.
cathepsin x deficiency
IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells.
cathepsin x deficiency
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Cholangitis
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.
Colorectal Neoplasms
Cathepsin X in serum from patients with colorectal cancer: relation to prognosis.
Colorectal Neoplasms
Characterization of cathepsin X in colorectal cancer development and progression.
Colorectal Neoplasms
KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation.
Colorectal Neoplasms
Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients.
Encephalomyelitis
A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
Encephalomyelitis, Autoimmune, Experimental
A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
Gallbladder Neoplasms
Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.
Gastritis
Cathepsin X prevents an effective immune response against Helicobacter pylori infection.
Gastritis
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Glioma
Localization patterns of cathepsins K and X and their predictive value in glioblastoma.
Hepatitis
[Distribution and activity of lysosomal protein catabolic-enzymes of rat liver in galactosamine hepatitis: catepsin D, cathepsin A and acid carboxypeptidase]
Infections
Cathepsin X prevents an effective immune response against Helicobacter pylori infection.
Infections
Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after helicobacter pylori infection.
Infections
Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa.
Infections
Generation of a single-chain variable fragment phage display antibody library from naïve mice panned against Fasciola hepatica antigens.
Infections
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Infections
Vaccination of mice with recombinant novel aminopeptidase P and cathepsin X alone or in combination induces protective immunity against Trichinella spiralis infection.
Inflammatory Breast Neoplasms
Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer.
Intestinal Volvulus
The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development.
Liver Cirrhosis, Biliary
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.
Liver Diseases
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.
Lung Neoplasms
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
Multiple Sclerosis
A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
Neoplasm Metastasis
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
Neoplasm Metastasis
Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.
Neoplasm Metastasis
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Neoplasms
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
Neoplasms
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularisation in mice.
Neoplasms
Cathepsin X Cleaves Profilin 1 C-Terminal Tyr139 and Influences Clathrin-Mediated Endocytosis.
Neoplasms
Cathepsin X in serum from patients with colorectal cancer: relation to prognosis.
Neoplasms
Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location.
Neoplasms
Characterization of cathepsin X in colorectal cancer development and progression.
Neoplasms
Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.
Neoplasms
Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer.
Neoplasms
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Neoplasms
Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
Neoplasms
Identification and characterization of the novel reversible and selective cathepsin X inhibitors.
Neoplasms
IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells.
Neoplasms
Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation.
Neoplasms
Intracellular signaling by cathepsin X: Molecular mechanisms and diagnostic and therapeutic opportunities in cancer.
Neoplasms
Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.
Neoplasms
Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.
Neoplasms
Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X.
Neoplasms
Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
Neoplasms
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer.
Neoplasms
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Neoplasms
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia.
Neuroblastoma
Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells.
Neurodegenerative Diseases
Cathepsin X in serum from patients with colorectal cancer: relation to prognosis.
Neurodegenerative Diseases
Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells.
Neurodegenerative Diseases
Identification and characterization of the novel reversible and selective cathepsin X inhibitors.
Neurodegenerative Diseases
Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo.
Neurodegenerative Diseases
Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X.
Neuroendocrine Tumors
Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix.
Neuroinflammatory Diseases
A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis.
Neuroinflammatory Diseases
Inhibition of cathepsin X reduces the strength of microglial-mediated neuroinflammation.
Neuroinflammatory Diseases
Neuroinflammation-Induced Upregulation of Glial Cathepsin X Expression and Activity in vivo.
Neuroinflammatory Diseases
Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson's Disease.
Non-ST Elevated Myocardial Infarction
Lysophospholipids as Predictive Markers of ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI).
Pancreatic Neoplasms
S100P-Binding Protein, S100PBP, Mediates Adhesion through Regulation of Cathepsin Z in Pancreatic Cancer Cells.
Parkinson Disease
Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells.
Parkinson Disease
Upregulation of Cysteine Protease Cathepsin X in the 6-Hydroxydopamine Model of Parkinson's Disease.
Pheochromocytoma
Cathepsin X promotes 6-hydroxydopamine-induced apoptosis of PC12 and SH-SY5Y cells.
Prostatic Intraepithelial Neoplasia
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia.
Prostatic Neoplasms
Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer.
Prostatic Neoplasms
Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X.
Prostatic Neoplasms
Up-regulation of cathepsin X in prostate cancer and prostatic intraepithelial neoplasia.
Sepsis
Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.
Stomach Neoplasms
Cathepsin X-deficient gastric epithelial cells in co-culture with macrophages: characterization of cytokine response and migration capability after helicobacter pylori infection.
Stomach Neoplasms
Regulation of cathepsin X overexpression in H. pylori-infected gastric epithelial cells and macrophages.
Stomach Neoplasms
Up-regulation of cathepsin X in Helicobacter pylori gastritis and gastric cancer.
Tuberculosis
Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study.
Tuberculosis
Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.
Tuberculosis
Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.
Tuberculosis, Pulmonary
Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis.
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