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Disease on EC 3.4.17.17 - tubulinyl-Tyr carboxypeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenomatous Polyposis Coli
Glycogen synthase kinase 3beta and the regulation of axon growth.
Alzheimer Disease
Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells.
Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.
Ataxia
Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family.
Brain Injuries
Bilateral growth-related protein expression suggests a transient increase in regenerative potential following brain trauma.
Brain Ischemia
Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age.
Breast Neoplasms
Nanomechanical Property Maps of Breast Cancer Cells As Determined by Multiharmonic Atomic Force Microscopy Reveal Syk-Dependent Changes in Microtubule Stability Mediated by MAP1B.
Carcinoma
Role of Microtubule-Associated Protein 1b in Urothelial Carcinoma: Overexpression Predicts Poor Prognosis.
Carcinoma, Embryonal
Stable transfection of embryonal carcinoma cells with MAP1A and MAP1B antisense sequences.
Colorectal Neoplasms
Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3? (GSK-3?) and microtubule-associated protein 1B.
Drug Resistant Epilepsy
Evidence of abnormal differentiation in giant cells of tuberous sclerosis.
Epiretinal Membrane
Expression and upregulation of microtubule-associated protein 1B in cultured retinal pigment epithelial cells.
Fragile X Syndrome
The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences.
Galactosemias
Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models.
Ganglion Cysts
Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons.
Giant Axonal Neuropathy
Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family.
Glioblastoma
A Molecular Cascade Modulates MAP1B and Confers Resistance to mTOR Inhibition in Human Glioblastoma.
Glioma
Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.
Hirsutinolide Series Inhibit Stat3 Activity, Alter GCN1, MAP1B, Hsp105, G6PD, Vimentin, TrxR1, and Importin ?-2 Expression, and Induce Antitumor Effects against Human Glioma.
Hearing Loss
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
Hearing Loss, Sensorineural
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
Hypersensitivity
Structural analysis of the proximal region of the microtubule-associated protein 1B promoter.
Infarction, Middle Cerebral Artery
Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age.
Intellectual Disability
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
MAP1B mutations cause intellectual disability and extensive white matter deficit.
MAP1B related syndrome: Case presentation and review of literature.
Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family.
Lung Neoplasms
Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.
Malformations of Cortical Development
Early forms of microtubule-associated protein are strongly expressed in cortical dysplasia.
Internexin, MAP1B, and nestin in cortical dysplasia as markers of developmental maturity.
Microcephaly
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
MAP1B related syndrome: Case presentation and review of literature.
Muscular Atrophy
Adult-onset motor neuron disease and infantile Werdnig-Hoffmann disease (spinal muscular atrophy type 1) in the same family.
Muscular Atrophy, Spinal
Fine-mapping of the spinal muscular atrophy locus to a region flanked by MAP1B and D5S6.
Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13.
Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.
Refinement of the spinal muscular atrophy locus to the interval between D5S435 and MAP1B.
Neoplasm Metastasis
Advances in chemistry and bioactivity of parthenolide.
Differentiation of classic medulloblastoma into metastatic large cell medulloblastoma with focal rhabdoid differentiation in the absence of posterior fossa recurrence.
Neoplasms
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
A microtubule-associated protein MAP1B binds to and regulates localization of a calcium-binding protein ALG-2.
Differential expression of glu-tubulin in relation to mammary gland disease.
Differentiation of classic medulloblastoma into metastatic large cell medulloblastoma with focal rhabdoid differentiation in the absence of posterior fossa recurrence.
Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.
Interaction of the growth and tumour suppressor NORE1A with microtubules is not required for its growth-suppressive function.
Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.
PD-1-inhibitor-induced PCA-2 (MAP1B) Autoimmunity in a Patient with Renal Cell Carcinoma.
Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein.
Role of Microtubule-Associated Protein 1b in Urothelial Carcinoma: Overexpression Predicts Poor Prognosis.
Nervous System Diseases
Microtubule-associated protein 1B: Novel paraneoplastic biomarker.
Neuroblastoma
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
Implication of cyclin-dependent kinases and glycogen synthase kinase 3 in the phosphorylation of microtubule-associated protein 1B in developing neuronal cells.
Microtubule-associated protein 1B light chain (MAP1B-LC1) negatively regulates the activity of tumor suppressor p53 in neuroblastoma cells.
Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis.
S-Nitrosylation of microtubule-associated protein 1B mediates nitric-oxide-induced axon retraction.
Neurodegenerative Diseases
Overexpression of full-length but not N-terminal truncated isoform of microtubule-associated protein (MAP) 1B accelerates apoptosis of cultured cortical neurons.
Neuroectodermal Tumors, Primitive
Co-expression of low molecular weight neurofilament protein and glial fibrillary acidic protein in established human glioma cell lines.
Ovarian Neoplasms
Knockout of vasohibin-2 reduces tubulin carboxypeptidase activity and increases paclitaxel sensitivity in ovarian cancer.
Parkinson Disease
Axonal pathology in hPSC-based models of Parkinson's disease results from loss of Nrf2 transcriptional activity at the Map1b gene locus.
Periventricular Nodular Heterotopia
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia.
Epilepsy phenotypes associated with MAP1B-related brain malformations.
MAP1B related syndrome: Case presentation and review of literature.
Pheochromocytoma
Attenuation of microtubule-associated protein 1B expression by antisense oligodeoxynucleotides inhibits initiation of neurite outgrowth.
The MAP kinase pathway is upstream of the activation of GSK3beta that enables it to phosphorylate MAP1B and contributes to the stimulation of axon growth.
Pulmonary Disease, Chronic Obstructive
Epigenetic Repression of CCDC37 and MAP1B Links Chronic Obstructive Pulmonary Disease to Lung Cancer.
Rhabdomyosarcoma
A comparative immunohistochemical analysis of small round cell tumors of childhood: utility of peripherin and alpha-internexin as markers for neuroblastomas.
Sciatic Neuropathy
Induction of microtubule-associated protein 1B expression in Schwann cells during nerve regeneration.
Seizures
Altered expression of microtubule-associated protein 1B in cerebral cortical structures of pentylenetetrazole-treated rats.
Autism and Intellectual Disability-Associated KIRREL3 Interacts with Neuronal Proteins MAP1B and MYO16 with Potential Roles in Neurodevelopment.
Epilepsy phenotypes associated with MAP1B-related brain malformations.
Increased expression of microtubule-associated protein 1B in the hippocampus, subiculum, and perforant path of rats treated with a high dose of pentylenetetrazole.
Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period.
MAP1B related syndrome: Case presentation and review of literature.
Pentylenetetrazole-induced seizure up-regulates levels of microtubule-associated protein 1B mRNA and protein in the hippocampus of the rat.
Synaptic plasticity is preserved in the temporal cortex of 20-month-old rats.
Sleep Initiation and Maintenance Disorders
iTRAQ-based proteomics analysis on insomnia rats treated with Mongolian medical warm acupuncture.
Starvation
DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing.
Stroke
Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats.
Temporal dynamics of degenerative and regenerative events associated with cerebral ischemia in aged rats.
Upregulation of MAP1B and MAP2 in the rat brain after middle cerebral artery occlusion: effect of age.
Tuberous Sclerosis
Evidence of abnormal differentiation in giant cells of tuberous sclerosis.
tubulinyl-tyr carboxypeptidase deficiency
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity.
MAP1B-dependent Rac activation is required for AMPA receptor endocytosis during long-term depression.
Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss.
QKI Binds MAP1B mRNA and Enhances MAP1B Expression during Oligodendrocyte Development.
The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.
Vitreoretinopathy, Proliferative
Expression and upregulation of microtubule-associated protein 1B in cultured retinal pigment epithelial cells.