Reference on EC 3.4.17.11 - glutamate carboxypeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
McCullough, J.L.; Chabner, B.A.; Bertino, J.R.
Purification and properties of carboxypeptidase G 1
J. Biol. Chem.
246
7207-7213
1971
Pseudomonas stutzeri
Goldman, P.; Levy, C.C.
Carboxypeptidase G: purification and properties
Proc. Natl. Acad. Sci. USA
58
1299-1306
1967
Pseudomonas sp.
Albrecht, A.M.; Boldizsar, E.; Hutchinson, D.J.
Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin
J. Bacteriol.
134
506-513
1978
Flavobacterium sp.
Sherwood, R.F.; Melton, R.G.; Alwan, S.M.; Hughes, P.
Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method
Eur. J. Biochem.
148
447-453
1985
Pseudomonas sp.
Lloyd, L.F.; Collyer, C.A.; Sherwood, R.F.
Crystallization and preliminary crystallographic analysis of carboxypeptidase G2 from Pseudomonas sp. strain RS-16
J. Mol. Biol.
220
17-18
1991
Pseudomonas sp.
Rowsell, S.; Pauptit, R.A.; Tucker, A.D.; Melton, R.G.; Blow, D.M.; Brick, P.
Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy
Structure
5
337-347
1997
Pseudomonas sp.
Niculescu-Duvaz, D.; Niculescu-Duvaz, I.; Friedlos, F.; Martin, J.; Lehouritis, P.; Marais, R.; Springer, C.J.
Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT
J. Med. Chem.
46
1690-1705
2003
Pseudomonas sp.
Masterson, L.A.; Spanswick, V.J.; Hartley, J.A.; Begent, R.H.; Howard, P.W.; Thurston, D.E.
Synthesis and biological evaluation of novel pyrrolo[2,1-c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy
Bioorg. Med. Chem. Lett.
16
252-256
2006
Homo sapiens
Buchen, S.; Ngampolo, D.; Melton, R.G.; Hasan, C.; Zoubek, A.; Henze, G.; Bode, U.; Fleischhack, G.
Carboxypeptidase G2 rescue in patients with methotrexate intoxication and renal failure
Br. J. Cancer
92
480-487
2005
Pseudomonas sp.
Hempel, G.; Lingg, R.; Boos, J.
Interactions of carboxypeptidase G2 with 6S-leucovorin and 6R-leucovorin in vitro: implications for the application in case of methotrexate intoxications
Cancer Chemother. Pharmacol.
55
347-353
2005
Homo sapiens
Davies, L.C.; Friedlos, F.; Hedley, D.; Martin, J.; Ogilvie, L.M.; Scanlon, I.J.; Springer, C.J.
Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy
J. Med. Chem.
48
5321-5328
2005
Pseudomonas sp., Pseudomonas sp. RS16
Mayer, A.; Francis, R.J.; Sharma, S.K.; Tolner, B.; Springer, C.J.; Martin, J.; Boxer, G.M.; Bell, J.; Green, A.J.; Hartley, J.A.; Cruickshank, C.; Wren, J.; Chester, K.A.; Begent, R.H.
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug
Clin. Cancer Res.
12
6509-6516
2006
Pseudomonas aeruginosa
Pedone, E.; Searle, F.; Brocchini, S.
Diethylstilbestrol glutamate as a potential substrate for ADEPT
J. Drug Target.
14
437-443
2006
Pseudomonas sp.
Friedlos, F.; Lehouritis, P.; Ogilvie, L.; Hedley, D.; Davies, L.; Bermudes, D.; King, I.; Martin, J.; Marais, R.; Springer, C.J.
Attenuated Salmonella targets prodrug activating enzyme carboxypeptidase G2 to mouse melanoma and human breast and colon carcinomas for effective suicide gene therapy
Clin. Cancer Res.
14
4259-4266
2008
Pseudomonas sp.
Mancini, L.; Davies, L.; Friedlos, F.; Falck-Miniotis, M.; Dzik-Jurasz, A.S.; Springer, C.J.; Leach, M.O.; Payne, G.S.
A novel technique to monitor carboxypeptidase G2 expression in suicide gene therapy using (19)F magnetic resonance spectroscopy
NMR Biomed.
22
561-566
2009
Homo sapiens
Kawakatsu, T.; Taramino, G.; Itoh, J.I.; Allen, J.; Sato, Y.; Hong, S.K.; Yule, R.; Nagasawa, N.; Kojima, M.; Kusaba, M.; Sakakibara, H.; Sakai, H.; Nagato, Y.
PLASTOCHRON3/GOLIATH encodes a glutamate carboxypeptidase required for proper development in rice
Plant J.
58
1028-1040
2009
Oryza sativa (Q852M4), Oryza sativa
Jamin, Y.; Gabellieri, C.; Smyth, L.; Reynolds, S.; Robinson, S.P.; Springer, C.J.; Leach, M.O.; Payne, G.S.; Eykyn, T.R.
Hyperpolarized (13)C magnetic resonance detection of carboxypeptidase G2 activity
Magn. Reson. Med.
62
1300-1304
2009
Pseudomonas sp.
Carozzi, V.A.; Chiorazzi, A.; Canta, A.; Lapidus, R.G.; Slusher, B.S.; Wozniak, K.M.; Cavaletti, G.
Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat
Neurotox. Res.
17
380-391
2010
Rattus norvegicus
Goda, S.K.; Rashidi, F.A.; Fakharo, A.A.; Al-Obaidli, A.
Functional overexpression and purification of a codon optimized synthetic glucarpidase (carboxypeptidase G2) in Escherichia coli
Protein J.
28
435-442
2009
Pseudomonas sp. (P06621), Pseudomonas sp.
Jamin, Y.; Eykyn, T.R.; Poon, E.; Springer, C.J.; Robinson, S.P.
Detection of the prodrug-activating enzyme carboxypeptidase G2 activity with chemical exchange saturation transfer magnetic resonance
Mol. Imaging Biol.
16
152-157
2014
Pseudomonas sp. (P06621)
Al-Qahtani, A.D.; Bashraheel, S.S.; Rashidi, F.B.; OConnor, C.D.; Romero, A.R.; Domling, A.; Goda, S.K.
Production of "biobetter" variants of glucarpidase with enhanced enzyme activity
Biomed. Pharmacother.
112
108725
2019
Pseudomonas sp. RS-16 (P06621)
Jeyaharan, D.; Brackstone, C.; Schouten, J.; Davis, P.; Dixon, A.M.
Characterisation of the carboxypeptidase G2 catalytic site and design of new inhibitors for cancer therapy
ChemBioChem
19
1959-1968
2018
Pseudomonas sp. RS-16 (P06621)
Yachnin, B.J.; Khare, S.D.
Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme
Protein Eng. Des. Sel.
30
321-331
2017
Pseudomonas sp. RS-16 (P06621)
Jeyaharan, D.; Aston, P.; Garcia-Perez, A.; Schouten, J.; Davis, P.; Dixon, A.M.
Soluble expression, purification and functional characterisation of carboxypeptidase G2 and its individual domains
Protein Expr. Purif.
127
44-52
2016
Pseudomonas sp. RS-16 (P06621)
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