Reference on EC 3.4.14.10 - tripeptidyl-peptidase II
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Balw, R.M.; Ragnarsson, U.; Zetterquist, .
Tripeptidyl aminopeptidase in the extralysosomal fraction of rat liver
J. Biol. Chem.
258
11622-11628
1983
Rattus norvegicus
Tomkinson, B.; Wernstedt, C.; Hellman, U.; Zetterquist, .
Active site of tripeptidyl peptidase II from human erythrocytes is of the subtilisin type
Proc. Natl. Acad. Sci. USA
84
7508-7512
1987
Homo sapiens
Balw, R.M.; Tomkinson, B.; Ragnarsson, U.; Zetterquist, .
Purification, substrate specificity, and classification of tripeptidyl peptidase II
J. Biol. Chem.
261
2409-2417
1986
Homo sapiens, Rattus norvegicus
Macpherson, E.; Tomkinson, B.; Balw, R.M.; Hglund, S.; Zetterquist, .
Supramolecular structure of tripeptidyl peptidase II from human erythrocytes as studied by electron microscopy, and its correlation to enzyme activity
Biochem. J.
248
259-263
1987
Homo sapiens
Balw, R.M.; Eriksson, I.
Tripeptidyl peptidase II in haemolysates and liver homogenates of various species
Biochem. J.
241
75-80
1987
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Equus caballus, Homo sapiens, Platyrrhini, no activity in Escherichia coli, Rattus norvegicus, Sus scrofa
Tomkinson, B.; Zetterquist, .
Immunological cross-reactivity between human tripeptidyl peptidase II and fibronectin
Biochem. J.
267
149-154
1990
Homo sapiens
Tomkinson, B.; Grehn, L.; Fransson, B.; Zetterquist, ?.
Use of a dehydroalanine-containing peptide as an efficient inhibitor of tripeptidyl peptidase II
Arch. Biochem. Biophys.
314
276-279
1994
Homo sapiens
Tomkinson, B.; Nyberg, F.
Distribution of tripeptidyl-peptidase II in the central nervous system of rat
Neurochem. Res.
20
1443-1447
1995
Rattus norvegicus
Matrinsson, T.; Vujic, M.; Tomkinson, B.
Localization of the human tripeptidyl peptidase II gene (TPP2) to 13q32-q33 by nonradioactive in situ hybridization and somatic cell hybrids
Genomics
17
493-495
1993
Homo sapiens
Wilson, C.; Gibosn, A.M.; McDermott, J.R.
Purification and characterization of tripeptidylpeptidase-II from post-mortem human brain
Neurochem. Res.
18
743-749
1993
Homo sapiens
Tomkinson, B.
Nucleotide sequence of cDNA covering the N-terminus of human tripeptidyl peptidase II
Biomed. Biochim. Acta
50
727-729
1991
Homo sapiens
Harris, J.; Tomkinson, B.
Electron microscopical and biochemical studies on the oligomeric states of human erythrocyte tripeptidyl peptidase-II
Micron Microsc. Acta
21
77-89
1990
Homo sapiens
-
Tomkinson, B.
Characterization of cDNA for murine tripeptidyl-peptidase II reveals alternative splicing [published erratum appears in Biochem J 1995 Mar 15;306(Pt 3):880]
Biochem. J.
304
517-523
1994
Mus musculus
Tomkinson, B.
Association and dissociation of the tripeptidyl-peptidase II complex as a way of regulating the enzyme activity
Arch. Biochem. Biophys.
376
275-280
2000
Homo sapiens
Tomkinson, B.; Ni Laoi, B.; Wellington, K.
The insert within the catalytic domain of tripeptidyl-peptidase II is important for the formation of the active complex
Eur. J. Biochem.
269
1438-1443
2002
Homo sapiens, Mus musculus
Tomkinson, B.; Hansen, M.; Cheung, W.F.
Structure-function studies of recombinant murine tripeptidyl-peptidase II: the extra domain which is subject to alternative splicing is involved in complex formation
FEBS Lett.
405
277-280
1997
Mus musculus
Renn, S.C.; Tomkinson, B.; Taghert, P.H.
Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster
J. Biol. Chem.
273
19173-19182
1998
Drosophila melanogaster, Rattus norvegicus
Ganellin, C.R.; Bishop, P.B.; Bambal, R.B.; Chan, S.M.; Law, J.K.; Marabout, B.; Luthra, P.M.; Moore, A.N.; Peschard, O.; Bourgeat, P.; Rose, C.; Vargas, F.; Schwartz, J.C.
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors
J. Med. Chem.
43
664-674
2000
Rattus norvegicus
Breslin, H.J.; Miskowski, T.A.; Kukla, M.J.; Leister, W.H.; De Winter, H.L.; Gauthier, D.A.; Somers, M.V.; Peeters, D.C.; Roevens, P.W.
Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles
J. Med. Chem.
45
5303-5310
2002
Rattus norvegicus
Hilbi, H.; Jozsa, E.; Tomkinson, B.
Identification of the catalytic triad in tripeptidyl-peptidase II through site-directed mutagenesis
Biochim. Biophys. Acta
1601
149-154
2002
Homo sapiens
Radu, D.; Tomkinson, B.; Zachrisson, O.; Weber, G.; de Belleroche, J.; Hirsch, S.; Lindefors, N.
Overlapping regional distribution of CCK and TPPII mRNAs in Cynomolgus monkey brain and correlated levels in human cerebral cortex (BA 10)
Brain Res.
1104
175-182
2006
Macaca fascicularis, Rattus norvegicus, Homo sapiens (P29144)
Chand, A.; Wyke, S.M.; Tisdale, M.J.
Effect of cancer cachexia on the activity of tripeptidyl-peptidase II in skeletal muscle
Cancer Lett.
218
215-222
2005
Mus musculus
Lindas, A.C.; Tomkinson, B.
Identification and characterization of the promoter for the gene encoding human tripeptidyl-peptidase II
Gene
345
249-257
2005
Homo sapiens
Reits, E.; Neijssen, J.; Herberts, C.; Benckhuijsen, W.; Janssen, L.; Drijfhout, J.W.; Neefjes, J.
A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation
Immunity
20
495-506
2004
Homo sapiens
Tomkinson, B.; Lindas, A.C.
Tripeptidyl-peptidase II: a multi-purpose peptidase
Int. J. Biochem. Cell Biol.
37
1933-1937
2005
Homo sapiens
Seyit, G.; Rockel, B.; Baumeister, W.; Peters, J.
Size matters: the spindle form of the 6 MDA tripeptidylpeptidase II from drosophila melanogaster stabilizes the activated state
J. Biol. Chem.
281
25723-25733
2006
Drosophila sp. (in: flies)
Ganellin, C.R.; Bishop, P.B.; Bambal, R.B.; Chan, S.M.; Leblond, B.; Moore, A.N.; Zhao, L.; Bourgeat, P.; Rose, C.; Vargas, F.; Schwartz, J.C.
Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors
J. Med. Chem.
48
7333-7342
2005
Rattus norvegicus
Book, A.J.; Yang, P.; Scalf, M.; Smith, L.M.; Vierstra, R.D.
Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis
Plant Physiol.
138
1046-1057
2005
Arabidopsis sp.
Rockel, B.; Peters, J.; Mueller, S.A.; Seyit, G.; Ringler, P.; Hegerl, R.; Glaeser, R.M.; Baumeister, W.
Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II
Proc. Natl. Acad. Sci. USA
102
10135-10140
2005
Drosophila sp. (in: flies)
Naujokat, C.; Fuchs, D.; Berges, C.
Adaptive modification and flexibility of the proteasome system in response to proteasome inhibition
Biochim. Biophys. Acta
1773
1389-1397
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Levengood, M.R.; van der Donk, W.A.
Use of lantibiotic synthetases for the preparation of bioactive constrained peptides
Bioorg. Med. Chem. Lett.
18
3025-3028
2008
Homo sapiens
Hong, X.; Lei, L.; Kuenert, B.; Naredla, R.; Applequist, S.E.; Grandien, A.; Glas, R.
Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors
Cancer Res.
67
7165-7174
2007
Homo sapiens
Bhutani, N.; Venkatraman, P.; Goldberg, A.L.
Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation
EMBO J.
26
1385-1396
2007
Homo sapiens (P29144)
Basler, M.; Groettrup, M.
No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes
Eur. J. Immunol.
37
896-904
2007
Homo sapiens
Endert, P.
Role of tripeptidyl peptidase II in MHC class I antigen processing - the end of controversies?
Eur. J. Immunol.
38
609-613
2008
Homo sapiens
Marcilla, M.; Villasevil, E.M.; de Castro, J.A.
Tripeptidyl peptidase II is dispensable for the generation of both proteasome-dependent and proteasome-independent ligands of HLA-B27 and other class I molecules
Eur. J. Immunol.
38
631-639
2008
Homo sapiens
Lindas, A.C.; Tomkinson, B.
Characterization of the promoter of the gene encoding human tripeptidyl-peptidase II and identification of upstream silencer elements
Gene
393
62-69
2007
Homo sapiens
Preuss, K.D.; Held, G.; Kubuschok, B.; Hung, C.Z.; Malatsidze, N.; Wagner, M.; Pfreundschuh, M.
Identification of antigenic targets of paraproteins by expression cloning does not support a causal role of chronic antigenic stimulation in the pathogenesis of multiple myeloma and MGUS
Int. J. Cancer
121
459-461
2007
Homo sapiens
Guil, S.; Rodriguez-Castro, M.; Aguilar, F.; Villasevil, E.M.; Anton, L.C.; Del Val, M.
Need for tripeptidyl-peptidase II in major histocompatibility complex class I viral antigen processing when proteasomes are detrimental
J. Biol. Chem.
281
39925-39934
2006
Homo sapiens
Huai, J.; Firat, E.; Nil, A.; Million, D.; Gaedicke, S.; Kanzler, B.; Freudenberg, M.; van Endert, P.; Kohler, G.; Pahl, H.L.; Aichele, P.; Eichmann, K.; Niedermann, G.
Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice
Proc. Natl. Acad. Sci. USA
105
5177-5182
2008
Mus musculus
Anton, L.C.; Villasevil, E.M.
Is there an alternative to the proteasome in cytosolic protein degradation?
Biochem. Soc. Trans.
36
839-842
2008
Homo sapiens
Lindas, A.C.; Eriksson, S.; Jozsa, E.; Tomkinson, B.
Investigation of a role for Glu-331 and Glu-305 in substrate binding of tripeptidyl-peptidase II
Biochim. Biophys. Acta
1784
1899-1907
2008
Mus musculus (Q64514)
Firat, E.; Tsurumi, C.; Gaedicke, S.; Huai, J.; Niedermann, G.
Tripeptidyl peptidase II plays a role in the radiation response of selected primary cell types but not based on nuclear translocation and p53 Sstabilization
Cancer Res.
69
3325-3331
2009
Mus musculus
Tye, C.E.; Lorenz, R.L.; Bartlett, J.D.
Lysosomal protease expression in mature enamel
Cells Tissues Organs
189
111-114
2009
Mus musculus
Schnurr, M.; Orban, M.; Robson, N.C.; Shin, A.; Braley, H.; Airey, D.; Cebon, J.; Maraskovsky, E.; Endres, S.
ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase II
J. Immunol.
182
1253-1259
2009
Homo sapiens
Oda, H.; Saiki, K.; Tonosaki, M.; Yajima, A.; Konishi, K.
Participation of the secreted dipeptidyl and tripeptidyl aminopeptidases in asaccharolytic growth of Porphyromonas gingivalis
J. Periodont. Res.
44
362-267
2008
Porphyromonas gingivalis, Porphyromonas gingivalis W83
Tsurumi, C.; Firat, E.; Gaedicke, S.; Huai, J.; Mandal, P.K.; Niedermann, G.
Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts
Biochem. Biophys. Res. Commun.
386
563-568
2009
Mus musculus (Q64514)
Grauling-Halama, S.; Bahr, U.; Schenk, S.; Geginat, G.
Role of tripeptidyl peptidase II in the processing of Listeria monocytogenes-derived MHC class I-presented antigenic peptides
Microbes Infect.
11
795-802
2009
Mus musculus
Nahalkova, J.; Tomkinson, B.
TPPII, MYBBP1A and CDK2 form a protein-protein interaction network
Arch. Biochem. Biophys.
564
128-135
2014
Homo sapiens
Eklund, S.; Dogan, J.; Jemth, P.; Kalbacher, H.; Tomkinson, B.
Characterization of the endopeptidase activity of tripeptidyl-peptidase II
Biochem. Biophys. Res. Commun.
424
503-507
2012
Mus musculus
Eklund, S.; Lindas, A.C.; Hamnevik, E.; Widersten, M.; Tomkinson, B.
Exploring the active site of tripeptidyl-peptidase II through studies of pH dependence of reaction kinetics
Biochim. Biophys. Acta
1824
561-570
2012
Drosophila melanogaster, Drosophila melanogaster (Q9V6K1), Homo sapiens, Mus musculus, Mus musculus (Q64514)
Usukura, K.; Kasamatsu, A.; Okamoto, A.; Kouzu, Y.; Higo, M.; Koike, H.; Sakamoto, Y.; Ogawara, K.; Shiiba, M.; Tanzawa, H.; Uzawa, K.
Tripeptidyl peptidase II in human oral squamous cell carcinoma
J. Cancer Res. Clin. Oncol.
139
123-130
2013
Homo sapiens, Homo sapiens (P29144)
Zhou, Y.; Ru, Y.; Wang, C.; Wang, S.; Zhou, Z.; Zhang, Y.
Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor
PLoS ONE
8
e66634
2013
Mus musculus, Mus musculus (Q64514)
Schoenegge, A.M.; Villa, E.; Foerster, F.; Hegerl, R.; Peters, J.; Baumeister, W.; Rockel, B.
The structure of human tripeptidyl peptidase II as determined by a hybrid approach
Structure
20
593-603
2012
Homo sapiens (P29144), Homo sapiens
Ekino, K.; Yonei, S.; Oyama, H.; Oka, T.; Nomura, Y.; Shin, T.
Cloning, purification, and characterization of tripeptidyl peptidase from Streptomyces herbaricolor TY-21
Appl. Biochem. Biotechnol.
184
239-252
2018
Kitasatospora herbaricolor (D1MVE1), Kitasatospora herbaricolor, Kitasatospora herbaricolor TY-21 (D1MVE1)
Bialy, L.P.; Kuckelkorn, U.; Henklein, P.; Fayet, J.; Wilczynski, G.M.; Kaminski, A.; Mlynarczuk-Bialy, I.
Changes in spatio-temporal localization of tripeptidyl peptidase II (TPPII) in murine colon adenocarcinoma cells during aggresome formation a microscopy study based on a novel fluorescent proteasome inhibitor
Histol. Histopathol.
34
359-372
2019
Mus musculus
Wiemhoefer, A.; Stargardt, A.; van der Linden, W.A.; Renner, M.C.; van Kesteren, R.E.; Stap, J.; Raspe, M.A.; Tomkinson, B.; Kessels, H.W.; Ovaa, H.; Overkleeft, H.S.; Florea, B.; Reits, E.A.
Tripeptidyl peptidase II mediates levels of nuclear phosphorylated ERK1 and ERK2
Mol. Cell. Proteomics
14
2177-2193
2015
Homo sapiens (P29144)
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