Reference on EC 3.4.13.22 - D-Ala-D-Ala dipeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wu, Z.; Walsh, C.T.
Phosphinate analogs of D-, D-dipeptides: slow-binding inhibition and proteolysis protection of VanX, a D-, D-dipeptidase required for vancomycin resistance in Enterococcus faecium
Proc. Natl. Acad. Sci. USA
92
11603-11607
1995
Enterococcus faecium, Enterococcus faecium BM4147
Wu, Z.; Wright, G.D.; Walsh, C.T.
Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147
Biochemistry
34
2455-2463
1995
Enterococcus faecium (Q06241)
McCafferty, D.G.; Lessard, I.A.; Walsh, C.T.
Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX
Biochemistry
36
10498-10505
1997
Enterococcus sp.
Araoz, R.; Anhalt, E.; Rene, L.; Badet-Denisot, M.A.; Courvalin, P.; Badet, B.
Mechanism-based inactivation of VanX, a D-alanyl-D-alanine dipeptidase necessary for vancomycin resistance
Biochemistry
39
15971-15979
2000
Enterococcus sp.
Bussiere, D.E.; Pratt, S.D.; Katz, L.; Severin, J.M.; Holzman, T.; Park, C.H.
The structure of VanX reveals a novel amino-dipeptidase involved in mediating transposon-based vancomycin resistance
Mol. Cell
2
75-84
1998
Enterococcus faecium
Tan, A.L.; Loke, P.; Sim, T.S.
Molecular cloning and functional characterisation of VanX, a D-alanyl-D-alanine dipeptidase from Streptomyces coelicolor A3(2)
Res. Microbiol.
153
27-32
2002
Streptomyces coelicolor (Q9XAK6), Streptomyces coelicolor, Streptomyces coelicolor A3(2) (Q9XAK6), Streptomyces coelicolor A3(2)
Golich, F.C.; Sigdel, T.; Breece, R.M.; Detar, L.; Herron, L.R.; Crowder, M.W.
L-Alanine-p-nitroanilide is not a substrate for VanX
Anal. Biochem.
331
398-400
2004
Enterococcus faecium
Hsieh, M.L.; Tseng, M.J.; Tseng, M.C.; Chu, Y.H.
Identification of a new chromophoric substrate in the library of amino acid p-nitroanilides for continuous assay of VanX, a D,D-dipeptidase essential for vancomycin resistance
Anal. Biochem.
354
104-110
2006
Enterococcus faecium (Q06241)
Podmore, A.H.B.; Reynolds, P.E.
Purification and characterization of VanXYc, a D,D-dipeptidase/D,D-carboxypeptidase in vancomycin-resisitant Enterococcus gallinarium BM4174
Eur. J. Biochem.
269
2740-2746
2002
Enterococcus gallinarum, Enterococcus gallinarum BM4174
Breece, R.M.; Costello, A.; Bennett, B.; Sigdel, T.K.; Matthews, M.L.; Tierney, D.L.; Crowder, M.W.
A five-coordinate metal center in Co(II)-substituted VanX
J. Biol. Chem.
280
11074-11081
2005
Enterococcus faecium
Anissimova, M.; Yaouancq, L.; Noor, F.; Badet-Denisot, M.; Badet, B.
New chromogenic dipeptide substrate for continuous assay of the D-alanyl-D-alanine dipeptidase VanX required for high-level vancomycin resistance. [Erratum to document cited in CA140:089710]
J. Pept. Res.
62
186
2003
Enterococcus sp.
Chang, Y.P.; Tseng, M.J.; Chu, Y.H.
Using surface plasmon resonance to directly measure slow binding of low-molecular mass inhibitors to a VanX chip
Anal. Biochem.
359
63-71
2006
Enterococcus faecium
Crowder, M.W.
Combating vancomycin resistance in bacteria: targeting the D-ala-D-ala dipeptidase VanX
Infect. Disord. Drug Targets
6
147-158
2006
Enterococcus faecium
Matthews, M.L.; Periyannan, G.; Hajdin, C.; Sidgel, T.K.; Bennett, B.; Crowder, M.W.
Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme
J. Am. Chem. Soc.
128
13050-13051
2006
Enterococcus faecium
Deghorain, M.; Goffin, P.; Fontaine, L.; Mainardi, J.L.; Daniel, R.; Errington, J.; Hallet, B.; Hols, P.
Selectivity for D-lactate incorporation into the peptidoglycan precursors of Lactobacillus plantarum: role of Aad, a VanX-like D-alanyl-D-alanine dipeptidase
J. Bacteriol.
189
4332-4337
2007
Lactiplantibacillus plantarum
Kamioka, T.; Sohya, S.; Wu, N.; Maki, T.; Matsuda, T.; Ikegami, T.; Nakamura, H.; Kuroda, Y.
Extraction of recombinant protein from Escherichia coli by using a novel cell autolysis activity of VanX
Anal. Biochem.
439
212-217
2013
Escherichia coli
Jia, C.; Yang, K.; Liu, C.; Feng, L.; Xiao, J.; Zhou, L.; Zhang, Y.
Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX
Bioorg. Med. Chem. Lett.
22
482-484
2012
Enterococcus faecium
Sohya, S.; Kamioka, T.; Fujita, C.; Maki, T.; Ohta, Y.; Kuroda, Y.
Biochemical and biophysical characterization of an unexpected bacteriolytic activity of VanX, a member of the vancomycin-resistance vanA gene cluster
J. Biol. Chem.
289
35686-35694
2014
Escherichia coli
Liu, C.; Zhao, X.; Yang, K.; Xu, K.; Zhai, L.; Yang, X.; Gao, H.
Exploring antibiotic resistance based on enzyme hydrolysis by microcalorimetry: Part IV. Determination of thermokinetic parameters of D-Ala-D-Ala hydrolysis with dipeptidase VanX
J. Therm. Anal. Calorim.
111
1663-1667
2013
Enterococcus faecium
-
Meziane-Cherif, D.; Stogios, P.J.; Evdokimova, E.; Savchenko, A.; Courvalin, P.
Structural basis for the evolution of vancomycin resistance D,D-peptidases
Proc. Natl. Acad. Sci. USA
111
5872-5877
2014
Enterococcus faecalis (Q9JN36)
Van Der Aart, L.; Lemmens, N.; Van Wamel, W.; Van Wezel, G.
Substrate inhibition of VanA by D-alanine reduces vancomycin resistance in a VanX-dependent manner
Antimicrob. Agents Chemother.
60
4930-4939
2016
Streptomyces coelicolor, Streptomyces coelicolor ATCC BAA-471
Lv, M.; Zhang, Y.J.; Zhou, F.; Ge, Y.; Zhao, M.H.; Liu, Y.; Yang, K.W.
Real-time monitoring of D-Ala-D-Ala dipeptidase activity of VanX in living bacteria by isothermal titration calorimetry
Anal. Biochem.
578
29-35
2019
Enterococcus faecalis
Lee, S.J.; Jang, J.H.; Yoon, G.Y.; Kang, D.R.; Park, H.J.; Shin, S.J.; Han, H.D.; Kang, T.H.; Park, W.S.; Yoon, Y.K.; Soh, B.Y.; Jung, I.D.; Park, Y.M.
Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity
BMB Rep.
49
554-559
2016
Mycobacteroides abscessus (B1MNM5), Mycobacteroides abscessus, Mycobacteroides abscessus DSM 44196 (B1MNM5)
Hansen, T.; Pedersen, M.; Nielsen, L.; Ma, C.; Soes, L.; Worning, P.; Ostergaard, C.; Westh, H.; Pinholt, M.; Schonning, K.
Emergence of a vancomycin-variable Enterococcus faecium ST1421 strain containing a deletion in vanX
J. Antimicrob. Chemother.
73
2936-2940
2018
Enterococcus faecium
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