Reference on EC 3.4.11.9 - Xaa-Pro aminopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chen, K.C.S.; Buchanan, T.M.
Hydrolases from Neisseria gonorrhoeae. The study of gonocosin, an aminopeptidase-P, a proline iminopeptidase, and an asparaginase
J. Biol. Chem.
255
1704-1710
1980
Neisseria gonorrhoeae
Harada, M.; Mogi, M.; Fukasawa, K.; Fukasawa, F.M.
High-performance liquid chromatographic determination of aminopeptidase P activity in Fischer F344 rat serum and kidney
J. Chromatogr.
493
176-181
1989
Rattus norvegicus
Yoshimoto, T.; Murayama, N.; Tsuru, D.
A novel assay method for aminopeptidase P and partial purification of two types of the enzyme in Escherichia coli
Agric. Biol. Chem.
52
1957-1963
1988
Escherichia coli
-
Yoshimoto, T.; Murayama, N.; Honda, T.; Tone, H.; Tsuru, D.
Cloning and expression of aminopeptidase P gene from Escherichia coli HB101 and characterization of expressed enzyme
J. Biochem.
104
93-97
1988
Escherichia coli
Hooper, N.M.; Turner, A.J.
Ectoenzymes of the kidney microvillar membrane. Aminopeptidase P is anchored by a glycosyl-phosphatidylinositol moiety
FEBS Lett.
229
340-344
1988
Homo sapiens, Sus scrofa
Lasch, J.; Koelsch, R.; Steinmetzer, T.; Neumann, U.; Demuth, H.U.
Enzymic properties of intestinal aminopeptidase P: a new continuous assay
FEBS Lett.
227
171-174
1988
Rattus norvegicus
Holtzman, E.J.; Pillay, G.; Rosenthal, T.; Yaron, A.
Aminopeptidase P activity in rat organs and human serum
Anal. Biochem.
162
476-481
1987
Homo sapiens, Rattus norvegicus
Ryan, J.W.; Valido, F.; Berryer, P.; Chung, A.Y.K.; Ripka, J.E.
Purification and characterization of guinea pig serum aminoacylproline hydrolase (aminopeptidase P)
Biochim. Biophys. Acta
1119
140-147
1992
Cavia porcellus
Achstetter, T.; Ehmann, C.; Wolf, D.H.
Proteolysis in eucaryotic cells: aminopeptidases and dipeptidyl aminopeptidases of yeast revisited
Arch. Biochem. Biophys.
226
292-305
1983
Saccharomyces cerevisiae
Miller, C.G.; Green, L.
Degradation of proline peptides in peptidase-deficient strains of Salmonella typhimurium
J. Bacteriol.
153
350-356
1983
Salmonella enterica subsp. enterica serovar Typhimurium
Mc Donnell, M.; Fitzgerald, R.; Fhaolain, I.N.; Jennings, P.V.; O'Cuinn, G.
Purification and characterization of aminopeptidase P from Lactococcus lactis subsp. cremoris
J. Dairy Res.
64
399-407
1997
Lactococcus lactis
Lin, L.N.; Brandts, J.F.
Kinetic mechanism for conformational transitions between poly-L-prolines I and II: a study utilizing the cis-trans specificity of a proline-specific protease
Biochemistry
19
3055-3059
1980
Escherichia coli, Escherichia coli B / ATCC 11303
Yaron, A.; Mlynar, D.
Aminopeptidase-P
Biochem. Biophys. Res. Commun.
32
658-663
1968
Escherichia coli, Escherichia coli B / ATCC 11303
Fleminger, G.; Carmel, A.; Goldenberg, D.; Yaron, A.
Fluorogenic substrates for bacterial aminopeptidase P and its analogs detected in human serum and calf lung
Eur. J. Biochem.
125
609-615
1982
Bos taurus, Escherichia coli, Homo sapiens
Lin, L.N.; Brandts, J.F.
Role of cis-trans isomerism of the peptide bond in protease specificity. Kinetic studies on small proline-containing peptides and on polyproline
Biochemistry
18
5037-5042
1979
Escherichia coli
Orawski, A.T.; Simmons, W.H.
Purification and properties of membrane-bound aminopeptidase P from rat lung
Biochemistry
34
11227-11236
1995
Rattus norvegicus
Hooper, N.M.; Hryszko, J.; Turner, A.J.
Purification and characterization of pig kidney aminopeptidase P. A glycosyl-phosphatidylinositol-anchored ectoenzyme
Biochem. J.
267
509-515
1990
Sus scrofa
Simmons, W.H.; Orawski, A.T.
Membrane-bound aminopeptidase P from bovine lung. Its purification, properties, and degradation of bradykinin
J. Biol. Chem.
267
4897-4903
1992
Bos taurus
Harbeck, H.T.; Mentlein, R.
Aminopeptidase P from rat brain. Purification and action on bioactive peptides
Eur. J. Biochem.
198
451-458
1991
Rattus norvegicus
Lloyd, G.S.; Hryszko, J.; Hooper, N.M.; Turner, A.J.
Inhibition and metal ion activation of pig kidney aminopeptidase P. Dependence on nature of substrate
Biochem. Pharmacol.
52
229-236
1996
Sus scrofa
Orawski, A.T.; Susz, J.P.; Simmons, W.H.
Aminopeptidase P from bovine lung: solubilization, properties, and potential role in bradykinin degradation
Mol. Cell. Biochem.
75
123-132
1987
Bos taurus
Lloyd, G.S.; Habgood, N.T.; Hooper, N.M.; Turner, A.J.
Aminopeptidase P: immunoaffinity purification and molecular characterisation
Biochem. Soc. Trans.
236S
21
1993
Sus scrofa
-
Vanhoof, G.; de Block, J.; de Meester, I.; Scharpe, S.; de Potter, W.P.
Localization and characterization of aminopeptidase P in bovine adrenal medulla
Neurochem. Int.
21
203-208
1992
Bos taurus
Matsumoto, H.; Erickson, R.H.; Kim, Y.S.
Localization and characterization of rat small intestinal aminopeptidase P and its role in prolyl peptide digestion
J. Nutr. Biochem.
6
104-110
1995
Rattus norvegicus
-
Stckel, A.; Stiebitz, B.; Neubert, K.
Specific inhibitors of aminopeptidase P. Peptides and pseudopeptides of 2-hydroxy-3-amino acids
Adv. Exp. Med. Biol.
421
31-35
1997
Escherichia coli, Rattus norvegicus
Ryan, J.W.; Berryer, P.; Chung, A.Y.K.; Sheffy, D.H.
Characterization of rat pulmonary vascular aminopeptidase P in vivo: role in the inactivation of bradykinin
J. Pharmacol. Exp. Ther.
269
941-947
1994
Rattus norvegicus
Graham, S.C.; Lee, M.; Freeman, H.C.; Guss, J.M.
An orthorhombic form of Escherichia coli aminopeptidase P at 2.4 A resolution
Acta Crystallogr. Sect. D
59
897-902
2003
Escherichia coli
Cottrell, G.S.; Hooper, N.M.; Turner, A.J.
Cloning, expression, and characterization of human cytosolic aminopeptidase P: a single manganese(II)-dependent enzyme
Biochemistry
39
15121-15128
2000
Homo sapiens (Q9NQW7), Homo sapiens
Cottrell, G.S.; Hyde, R.J.; Lim, J.; Parsons, M.R.; Hooper, N.M.; Turner, A.J.
Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P
Biochemistry
39
15129-15135
2000
Sus scrofa
Wolfrum, S.; Richardt, G.; Dominiak, P.; Katus, H.A.; Dendorfer, A.
Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway
Br. J. Pharmacol.
134
370-374
2001
Rattus norvegicus
Laurent, V.; Brooks, D.R.; Coates, D.; Isaac, R.E.
Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans
Eur. J. Biochem.
268
5430-5438
2001
Caenorhabditis elegans
Kulkarni, G.V.; Deobagkar, D.D.
A cytosolic form of aminopeptidase P from Drosophila melanogaster: molecular cloning and characterization
J. Biochem.
131
445-452
2002
Drosophila melanogaster (O96794), Drosophila melanogaster
Hauser, F.; Strassner, J.; Schaller, A.
Cloning, expression, and characterization of tomato (Lycopersicon esculentum) aminopeptidase P
J. Biol. Chem.
276
31732-31737
2001
Solanum lycopersicum (Q93X45), Solanum lycopersicum (Q93X46), Solanum lycopersicum
Kim, K.S.; Kumar, S.; Simmons, W.H.; Brown, N.J.
Inhibition of aminopeptidase P potentiates wheal response to bradykinin in angiotensin-converting enzyme inhibitor-treated humans
J. Pharmacol. Exp. Ther.
292
295-298
2000
Homo sapiens
Adam, A.; Cugno, M.; Molinaro, G.; Perez, M.; Lepage, Y.; Agostoni, A.
Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors
Lancet
359
2088-2089
2002
Homo sapiens
Graham, S.C.; Maher, M.J.; Simmons, W.H.; Freeman, H.C.; Guss, J.M.
Structure of Escherichia coli aminopeptidase P in complex with the inhibitor apstatin
Acta Crystallogr. Sect. D
D60
1770-1779
2004
Escherichia coli
Lee, H.S.; Kim, Y.J.; Bae, S.S.; Jeon, J.H.; Lim, J.K.; Jeong, B.C.; Kang, S.G.; Lee, J.H.
Cloning, expression, and characterization of aminopeptidase P from the hyperthermophilic archaeon Thermococcus sp. strain NA1
Appl. Environ. Microbiol.
72
1886-1890
2006
Thermococcus onnurineus NA1 (Q2QC92)
Molinaro, G.; Carmona, A.K.; Juliano, M.A.; Juliano, L.; Malitskaya, E.; Yessine, M.A.; Chagnon, M.; Lepage, Y.; Simmons, W.H.; Boileau, G.; Adam, A.
Human recombinant membrane-bound aminopeptidase P: production of a soluble form and characterization using novel, internally quenched fluorescent substrates
Biochem. J.
385
389-397
2005
Homo sapiens
Graham, S.C.; Bond, C.S.; Freeman, H.C.; Guss, J.M.
Structural and functional implications of metal ion selection in aminopeptidase P, a metalloprotease with a dinuclear metal center
Biochemistry
44
13820-13836
2005
Escherichia coli (P15034), Escherichia coli
Jao, S.C.; Huang, L.F.; Hwang, S.M.; Li, W.S.
Tyrosine 387 and arginine 404 are critical in the hydrolytic mechanism of Escherichia coli aminopeptidase P
Biochemistry
45
1547-1553
2006
Escherichia coli
Graham, S.C.; Lilley, P.E.; Lee, M.; Schaeffer, P.M.; Kralicek, A.V.; Dixon, N.E.; Guss, J.M.
Kinetic and crystallographic analysis of mutant Escherichia coli aminopeptidase P: insights into substrate recognition and the mechanism of catalysis
Biochemistry
45
964-975
2006
Escherichia coli (P15034), Escherichia coli
Stockel-Maschek, A.; Stiebitz, B.; Koelsch, R.; Neubert, K.
Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors
Bioorg. Med. Chem.
13
4806-4820
2005
Escherichia coli, Rattus norvegicus
Sakamoto, K.; Sugimoto, K.; Sudoh, T.; Fujimura, A.
Different effects of imidapril and enalapril on aminopeptidase P activity in the mouse trachea
Hypertens. Res.
28
243-247
2005
Mus musculus
Zheng, Y.; Roberts, R.J.; Kasif, S.; Guan, C.
Characterization of two new aminopeptidases in Escherichia coli
J. Bacteriol.
187
3671-3677
2005
Escherichia coli
Graham, S.C.; Guss, J.M.
Complexes of mutants of Escherichia coli aminopeptidase P and the tripeptide substrate ValProLeu
Arch. Biochem. Biophys.
469
200-208
2008
Escherichia coli (P15034), Escherichia coli
Dalal, S.; Klemba, M.
Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum
J. Biol. Chem.
282
35978-35987
2007
Plasmodium falciparum (A0A144A2H0)
Arima, J.; Uesugi, Y.; Iwabuchi, M.; Hatanaka, T.
Streptomyces aminopeptidase P: biochemical characterization and insight into the roles of its N-terminal domain
Protein Eng. Des. Sel.
21
45-53
2008
Streptomyces lividans, Streptomyces murinus (A9E3K0), Streptomyces murinus TH-4 (A9E3K0)
Duan, Q.L.; Binkley, K.; Rouleau, G.A.
Genetic analysis of Factor XII and bradykinin catabolic enzymes in a family with estrogen-dependent inherited angioedema
J. Allergy Clin. Immunol.
123
906-910
2009
Homo sapiens
Li, X.; Lou, Z.; Li, X.; Zhou, W.; Ma, M.; Cao, Y.; Geng, Y.; Bartlam, M.; Zhang, X.C.; Rao, Z.
Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit
J. Biol. Chem.
283
22858-22866
2008
Homo sapiens
Masler, E.P.
Digestion of invertebrate neuropeptides by preparations from the free-living nematode Panagrellus redivivus
J. Helminthol.
82
279-285
2008
Panagrellus redivivus
La Corte, A.L.; Carter, A.M.; Turner, A.J.; Grant, P.J.; Hooper, N.M.
The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill
J. Renin Angiotensin Aldosterone Syst.
9
221-225
2008
Homo sapiens
Doria, C.; Elia, E.S.; Kang, Y.; Adam, A.; Desormeaux, A.; Ramirez, C.; Frank, A.; di Francesco, F.; Herman, J.H.
Acute hypotensive transfusion reaction during liver transplantation in a patient on angiotensin converting enzyme inhibitors from low aminopeptidase P activity
Liver Transpl.
14
684-687
2008
Homo sapiens
Hatanaka, T.; Onaka, H.; Arima, J.; Uraji, M.; Uesugi, Y.; Usuki, H.; Nishimoto, Y.; Iwabuchi, M.
pTONA5: a hyperexpression vector in Streptomycetes
Protein Expr. Purif.
62
244-248
2008
Streptomyces murinus (A9E3K0)
Ragheb, D.; Bompiani, K.; Dalal, S.; Klemba, M.
Evidence for catalytic roles for Plasmodium falciparum aminopeptidase P in the food vacuole and cytosol
J. Biol. Chem.
284
24806-24815
2009
Homo sapiens, Plasmodium falciparum
OToole, J.F.; Liu, Y.; Davis, E.E.; Westlake, C.J.; Attanasio, M.; Otto, E.A.; Seelow, D.; Nurnberg, G.; Becker, C.; Nuutinen, M.; Kaerppae, M.; Ignatius, J.; Uusimaa, J.; Pakanen, S.; Jaakkola, E.; van den Heuvel, L.P.; Fehrenbach, H.; Wiggins, R.; Goyal, M.; Zhou, W.; Wolf, M.T.; Wise, E.; Helou, J.; A, A.l.
Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy
J. Clin. Invest.
120
791-802
2010
Danio rerio, Escherichia coli, Homo sapiens (Q9NQH7), Homo sapiens
Chrastina, A.; Valadon, P.; Massey, K.A.; Schnitzer, J.E.
Lung Vascular Targeting Using Antibody to Aminopeptidase P: CT-SPECT Imaging, Biodistribution and Pharmacokinetic Analysis
J. Vasc. Res.
47
531-543
2010
Rattus norvegicus
Kumar, A.; Are, V.; Ghosh, B.; Agrawal, U.; Jamdar, S.; Makde, R.; Sharma, S.
Crystallization and preliminary X-ray diffraction analysis of Xaa-Pro dipeptidase from Xanthomonas campestris
Acta Crystallogr. Sect. F
70
1268-1271
2014
Xanthomonas campestris
Stressler, T.; Eisele, T.; Schlayer, M.; Fischer, L.
Production, active staining and gas chromatography assay analysis of recombinant aminopeptidase P from Lactococcus lactis ssp. lactis DSM 20481
AMB Express
2
39
2012
Lactococcus lactis subsp. lactis
Juarez-Montiel, M.; Ibarra, J.A.; Chavez-Camarillo, G.; Hernandez-Rodriguez, C.; Villa-Tanaca, L.
Molecular cloning and heterologous expression in Pichia pastoris of X-prolyl-dipeptidyl aminopeptidase from basidiomycete Ustilago maydis
Appl. Biochem. Biotechnol.
172
2530-2539
2014
Ustilago maydis
Yoon, S.H.; Bae, Y.S.; Mun, M.S.; Park, K.Y.; Ye, S.K.; Kim, E.; Kim, M.H.
Developmental retardation, microcephaly, and peptiduria in mice without aminopeptidase P1
Biochem. Biophys. Res. Commun.
429
204-209
2012
Mus musculus
Nandan, A.S.; Nampoothiri, K.M.
Unveiling aminopeptidase P from Streptomyces lavendulae: molecular cloning, expression and biochemical characterization
Enzyme Microb. Technol.
55
7-13
2014
Streptomyces lavendulae
Wu, S.; Liu, S.; Sim, S.; Pedersen, L.G.
Weakly antiferromagentic coupling via superexchange interaction between Mn(II)-Mn(II) atoms: A QM/MM study of the active site of human cytosolic X-propyl aminopeptidase P
J. Phys. Chem. Lett.
3
2293-2297
2012
Homo sapiens
Drinkwater, N.; Sivaraman, K.K.; Bamert, R.S.; Rut, W.; Mohamed, K.; Vinh, N.B.; Scammells, P.J.; Drag, M.; McGowan, S.
Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum
Biochem. J.
473
3189-3204
2016
Plasmodium falciparum
Cordova, A.; Woodrick, J.; Grindrod, S.; Zhang, L.; Saygideger-Kont, Y.; Wang, K.; DeVito, S.; Daniele, S.G.; Paige, M.; Brown, M.L.
Aminopeptidase P mediated targeting for breast tissue specific conjugate delivery
Bioconjug. Chem.
27
1981-1990
2016
Homo sapiens (O43895), Homo sapiens
Banu, S.K.; Stanley, J.A.; Sivakumar, K.K.; Arosh, J.A.; Barhoumi, R.; Burghardt, R.C.
Identifying a novel role for X-prolyl aminopeptidase (Xpnpep) 2 in CrVI-induced adverse effects on germ cell nest breakdown and follicle development in rats
Biol. Reprod.
92
67
2015
Rattus norvegicus (Q99MA2), Rattus norvegicus Sprague Dawley (Q99MA2)
Baik, A.S.; Mironov, K.S.; Arkhipov, D.V.; Piotrovskii, M.S.; Pojidaeva, E.S.
Characterization of aminopeptidase P from the unicellular cyanobacterium Synechocystis sp. PCC6803
Dokl. Biochem. Biophys.
481
190-194
2018
Synechocystis sp. PCC 6803 (P74468)
Singh, R.; Goyal, V.D.; Kumar, A.; Sabharwal, N.S.; Makde, R.D.
Crystal structures and biochemical analyses of intermediate cleavage peptidase role of dynamics in enzymatic function
FEBS Lett.
593
443-454
2019
Saccharomyces cerevisiae (P40051), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P40051)
Iyer, S.; La-Borde, P.J.; Payne, K.A.; Parsons, M.R.; Turner, A.J.; Isaac, R.E.; Acharya, K.R.
Crystal structure of X-prolyl aminopeptidase from Caenorhabditis elegans A cytosolic enzyme with a di-nuclear active site
FEBS open bio
5
292-302
2015
Caenorhabditis elegans (O44750), Caenorhabditis elegans
Giannoglou, M.; Alexandrakis, Z.; Stavros, P.; Katsaros, G.; Katapodis, P.; Nounesis, G.; Taoukis, P.
Effect of high pressure on structural modifications and enzymatic activity of a purified X-prolyl dipeptidyl aminopeptidase from Streptococcus thermophilus
Food Chem.
248
304-311
2018
Streptococcus thermophilus, Streptococcus thermophilus ACA DC 0022
Peng, C.T.; Liu, L.; Li, C.C.; He, L.H.; Li, T.; Shen, Y.L.; Gao, C.; Wang, N.Y.; Xia, Y.; Zhu, Y.B.; Song, Y.J.; Lei, Q.; Yu, L.T.; Bao, R.
Structure-function relationship of aminopeptidase P from Pseudomonas aeruginosa
Front. Microbiol.
8
2385
2017
Pseudomonas aeruginosa (A0A069Q0X9)
Matsushita-Morita, M.; Tada, S.; Suzuki, S.; Hattori, R.; Kusumoto, K.I.
Enzymatic characterization of a novel Xaa-Pro aminopeptidase XpmA from Aspergillus oryzae expressed in Escherichia coli
J. Biosci. Bioeng.
124
534-541
2017
Aspergillus oryzae (Q2U7S5), Aspergillus oryzae, Aspergillus oryzae RIB 40 (Q2U7S5), Aspergillus oryzae ATCC 42149 (Q2U7S5)
Arreola, R.; Villalpando, J.L.; Puente-Rivera, J.; Morales-Montor, J.; Rudino-Pinera, E.; Alvarez-Sanchez, M.E.
Trichomonas vaginalis metalloproteinase TvMP50 is a monomeric aminopeptidase P-like enzyme
Mol. Biotechnol.
60
563-575
2018
Trichomonas vaginalis (A2F8Y2), Trichomonas vaginalis
Drendel, V.; Heckelmann, B.; Chen, C.Y.; Weisser, J.; Espadas, G.; Schell, C.; Sabido, E.; Werner, M.; Jilg, C.A.; Schilling, O.
Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease
Oncotarget
8
100066-100078
2017
Homo sapiens (O43895), Homo sapiens (Q9NQW7), Homo sapiens
Yang, M.; Zheng, J.; Jia, H.; Song, M.
Functional characterization of X-prolyl aminopeptidase from Toxoplasma gondii
Parasitology
143
1443-1449
2016
Toxoplasma gondii, Toxoplasma gondii RH
Chang, H.C.; Kung, C.C.; Chang, T.T.; Jao, S.C.; Hsu, Y.T.; Li, W.S.
Investigation of the proton relay system operative in human cystosolic aminopeptidase P
PLoS ONE
13
e0190816
2018
Homo sapiens (Q9NQW7), Homo sapiens
Are, V.; Kumar, A.; Goyal, V.; Gotad, S.; Ghosh, B.; Gadre, R.; Jamdar, S.; Makde, R.
Structures and activities of widely conserved small prokaryotic aminopeptidases-P clarify classification of M24B peptidases
Proteins
87
212-225
2018
Deinococcus radiodurans (Q9RUY4), Deinococcus radiodurans ATCC 13939 (Q9RUY4), Deinococcus radiodurans DSM 20539 (Q9RUY4), Deinococcus radiodurans JCM 16871 (Q9RUY4), Deinococcus radiodurans LMG 4051 (Q9RUY4), Deinococcus radiodurans NBRC 15346 (Q9RUY4), Deinococcus radiodurans NCIMB 9279 (Q9RUY4), Deinococcus radiodurans R1 (Q9RUY4), Deinococcus radiodurans VKM B-1422 (Q9RUY4), Escherichia coli (P76524), Mycobacterium tuberculosis (I6YDN6), Mycobacterium tuberculosis ATCC 25618 (I6YDN6), Mycobacterium tuberculosis H37Rv (I6YDN6)
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