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Disease on EC 3.4.11.7 - glutamyl aminopeptidase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acute Kidney Injury
[Acute kidney failure. Non-invasive diagnosis of acute kidney failure in operative intensive care patients]
Albuminuria
A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. Induction of massive albuminuria after a single intravenous injection.
Albuminuria in mice after injection of antibodies against aminopeptidase A: role of angiotensin II.
Antibody-induced albuminuria and accelerated focal glomerulosclerosis in the Thy-1.1 transgenic mouse.
Epitope mapping of monoclonal antibodies directed to aminopeptidase A and their relevance for albuminuria in mice.
Induction of albuminuria in mice: synergistic effect of two monoclonal antibodies directed to different domains of aminopeptidase A.
Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: an angiotensin II-mediated effect?
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
Alzheimer Disease
Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease.
Astrocytoma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Blister
Biochemical and immunological properties of urinary angiotensinase A and dipeptidylaminopeptidase IV. Their use as markers in patients with renal cell injury.
Brain Neoplasms
Regulation of aminopeptidase A in human brain tumor vasculature: evidence for a role of transforming growth factor-beta.
Regulation of peptidase activity in a three-dimensional aggregate model of brain tumor vasculature.
Breast Neoplasms
Neoadjuvant chemotherapy modifies serum angiotensinase activities in women with breast cancer.
Renin angiotensin system-regulating aminopeptidase activities in serum of pre- and postmenopausal women with breast cancer.
Renin-Angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea.
Carcinogenesis
Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.
Carcinoma
Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor.
Carcinoma, Renal Cell
Regulation of the expression of aminopeptidase A, aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 in renal carcinoma cells and renal tubular epithelial cells by cytokines and cAMP-increasing mediators.
Carcinoma, Squamous Cell
Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor.
Cardiomyopathy, Dilated
Does the Aminopeptidase A (APA) Have Prognostic and Diagnostic Value in Chagas' Disease and Other Dilated Cardiomyopathies?
Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.
Cardiovascular Diseases
[Vasopeptidases and their inhibitors]
Cervical Intraepithelial Neoplasia
Regulation of aminopeptidase A expression in cervical carcinoma: role of tumor-stromal interaction and vascular endothelial growth factor.
Chagas Disease
Does the Aminopeptidase A (APA) Have Prognostic and Diagnostic Value in Chagas' Disease and Other Dilated Cardiomyopathies?
Cholesteatoma
Altered regulation of cell surface peptidases in human cholesteatoma.
Choriocarcinoma
Enhancement of aminopeptidase A expression during angiotensin II-induced choriocarcinoma cell proliferation through AT1 receptor involving protein kinase C- and mitogen-activated protein kinase-dependent signaling pathway.
Expression of aminopeptidase A in human gestational choriocarcinoma cell lines and tissues.
Colorectal Neoplasms
Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.
Diabetes Mellitus, Type 1
Urine RAS components in mice and people with type 1 diabetes and chronic kidney disease.
Diabetic Nephropathies
Biochemical and immunological properties of urinary angiotensinase A and dipeptidylaminopeptidase IV. Their use as markers in patients with renal cell injury.
[OP.6D.04] ASSOCIATION STUDY OF ANGIOTENSINASE A (ENPEP) GENOTYPE WITH DIABETIC NEPHROPATHY.
Digestive System Diseases
[The angiotensinase activity of -L-asparaginyl aminopeptidase in the serum of normal subjects, in patients with hepatobiliary diseases and during pregnancy]
Essential Hypertension
Association study: the aminopeptidase a gene and essential hypertension.
Central antihypertensive effects of orally active aminopeptidase a inhibitors in spontaneously hypertensive rats.
[Total plasma angiotensinase activity in essential hypertension]
Familial Primary Pulmonary Hypertension
Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.
Glomerulonephritis
Biochemical and immunological properties of urinary angiotensinase A and dipeptidylaminopeptidase IV. Their use as markers in patients with renal cell injury.
Inhibition of aminopeptidase A activity causes an acute albuminuria in mice: an angiotensin II-mediated effect?
Glomerulonephritis, Membranous
Mouse glomerular epithelial cells in culture with features of podocytes in vivo express aminopeptidase A and angiotensinogen but not other components of the renin-angiotensin system.
Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice.
Glomerulosclerosis, Focal Segmental
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
glutamyl aminopeptidase deficiency
Knockout of aminopeptidase A in mice causes functional alterations and morphological glomerular basement membrane changes in the kidneys.
Heart Failure
Specific Inhibition of Brain Angiotensin III Formation as a New Strategy for Prevention of Heart Failure After Myocardial Infarction.
Targeting Brain Aminopeptidase A: A New Strategy for the Treatment of Hypertension and Heart Failure.
[Vasopeptidases and their inhibitors]
Hydatidiform Mole
Differential distribution of placental leucine aminopeptidase/oxytocinase and aminopeptidase A in human trophoblasts of normal placenta and complete hydatidiform mole.
Hypertension
A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors.
A pilot double-blind randomized placebo-controlled crossover pharmacodynamic study of the centrally active aminopeptidase A inhibitor, firibastat, in hypertension.
Acetaldehyde inhibits serum aminopeptidases.
Activities of aminopeptidases in a rat saline model of volume hypertension.
Aminopeptidase A inhibitors as centrally acting antihypertensive agents.
Aminopeptidase A, pregnancy and hypertension.
Angiotensin III: a central regulator of vasopressin release and blood pressure.
Angiotensinase A (aminopeptidase A): properties of chromatographically purified isoforms from human kidney.
Biochemical and immunological properties of urinary angiotensinase A and dipeptidylaminopeptidase IV. Their use as markers in patients with renal cell injury.
Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension.
Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension.
Central antihypertensive effects of chronic treatment with RB150: an orally active aminopeptidase A inhibitor in deoxycorticosterone acetate-salt rats.
Central antihypertensive effects of orally active aminopeptidase a inhibitors in spontaneously hypertensive rats.
Contemporary and Future Concepts on Hypertension in African Americans: COVID-19 and Beyond.
Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats.
Effects of age, hypertension and HRT on serum aminopeptidase A activity.
Emerging Drug Classes and Their Potential Use in Hypertension.
Firibastat, the first-in-class brain aminopeptidase a inhibitor, in the management of hypertension: A review of clinical trials.
Firibastat: An Oral First-in-Class Brain Aminopeptidase A Inhibitor for Systemic Hypertension.
Focus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension.
High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism.
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension.
Jacques Benoit lecture: the neuroendocrine view of the angiotensin and apelin systems.
Kidney aminopeptidase A and hypertension, part I: spontaneously hypertensive rats.
Kidney aminopeptidase A and hypertension, part II: effects of angiotensin II.
Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension.
New insights into the importance of aminopeptidase A in hypertension.
NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension.
Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension.
Plasma angiotensin I concentration and serum placental leucine aminopeptidase (P-LAP) activities in puerperal hypertension.
PLASMA ANGIOTENSINASE ACTIVITY IN HUMAN HYPERTENSION.
Plasma angiotensinase activity in patients with hypertension and edema.
Plasmatic and erythrocytic angiotensinase activity in subjects with arterial hypertension.
Possible involvement of aminopeptidase A in hypertension and renal damage in Dahl salt-sensitive rats.
Possible involvement of aminopeptidase A in hypertension in spontaneously hypertensive rats (SHRs) and change of refractoriness in response to angiotensin II in pregnant SHRs.
Renal aminopeptidase activities in animal models of hypertension.
Renal expression of aminopeptidase A in rats with two-kidney, one-clip hypertension.
Renin-angiotensin system polymorphisms and risk of hypertension: influence of environmental factors.
Role of angiotensin III in hypertension.
Structural insights into central hypertension regulation by human aminopeptidase a.
Targeting Brain Aminopeptidase A: A New Strategy for the Treatment of Hypertension and Heart Failure.
The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs).
The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: its effect in comparison with candesartan.
The role of the brain renin-angiotensin system in hypertension: Implications for new treatment.
[Orally active aminopeptidase A inhibitors reduce blood pressure: a new strategy for treating hypertension].
[Plasma renin and angiotensinase activity in primary arterial hypertension in children and adolescents]
[Plasmatic angiotensinase activity in subjects with arterial hypertension of the essential type and of renal origin]
[Possible role of placental proteases via degradation of vasoactive peptides in the maternal and fetal blood pressure]
[Studies on hypertension accompanying renal failure: plasma renin activity and plasma angiotensinase activity in renal failure]
[Studies on plasma angiotensinase. Hypertension and plasma angiotensinase]
[Studies on serum angiotensinase. II. Clinical results in hypertension and liver diseases.]
[Symposium on the significance of enzymes in the field of internal medicine. (6). Renal hypertension and angiotensinase]
[Vasopeptidases and their inhibitors]
Hypertension, Pregnancy-Induced
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension.
Hypertension, Renal
Plasma angiotensinase activity in rabbits with experimental renal hypertension.
[Determination of plasma angiotensinase activity in patients with hypertensive disease and symptomatic renal hypertension]
[Studies on renal hypertension. VI: Studies on renal angiotensinase]
[Symposium on the significance of enzymes in the field of internal medicine. (6). Renal hypertension and angiotensinase]
Hypertension, Renovascular
Renal aminopeptidase activities in animal models of hypertension.
Hyperthyroidism
Angiotensinase activity in hypothalamus and pituitary of hypothyroid, euthyroid and hyperthyroid adult male rats.
Atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats.
Influence of thyroid disorders on kidney angiotensinase activity.
Thyroid Disorders Change the Pattern of Response of Angiotensinase Activities in the Hypothalamus-Pituitary-Adrenal Axis of Male Rats.
Infections
Visual Analysis and Inhibitor Screening of Leucine Aminopeptidase, a Key Virulence Factor for Pathogenic Bacteria-Associated Infection.
Kidney Neoplasms
Altered glutamyl-aminopeptidase activity and expression in renal neoplasms.
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.
Aminopeptidase A expression and enzymatic activity in primary human renal cancers.
Liver Cirrhosis
Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis.
Liver Diseases
Plasma angiotensinase activity in liver disease.
[Human plasmatic and erythrocytic angiotensinase activity in patients with liver diseases]
[Studies on serum angiotensinase. II. Clinical results in hypertension and liver diseases.]
Malaria
Identification of Potent and Selective Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) of Human Malaria via High-Throughput Screening.
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.
Myocardial Infarction
Brain renin-angiotensin system blockade with orally active aminopeptidase A inhibitor prevents cardiac dysfunction after myocardial infarction in mice.
Discrepancy between plasma and lung angiotensin-converting enzyme activity in experimental congestive heart failure. A novel aspect of endothelium dysfunction.
Novel role of aminopeptidase-A in angiotensin-(1-7) metabolism post myocardial infarction.
Specific Inhibition of Brain Angiotensin III Formation as a New Strategy for Prevention of Heart Failure After Myocardial Infarction.
[The activity of renin and angiotensinase in blood plasma of patients with acute myocardial infarct]
Neoplasms
Altered glutamyl-aminopeptidase activity and expression in renal neoplasms.
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma.
Aminopeptidase A expression in cervical neoplasia and its relationship to neoplastic transformation and progression.
Aminopeptidase A initiates tumorigenesis and enhances tumor cell stemness via TWIST1 upregulation in colorectal cancer.
Aminopeptidase A is a functional target in angiogenic blood vessels.
Aminopeptidase activities on the surface of mammalian cells and their alterations associated with transformation.
Antiproliferative effects of palladium(II) complexes of 5-nitrosopyrimidines and interactions with the proteolytic regulatory enzymes of the renin-angiotensin system in tumoral brain cells.
Changes in cell-surface peptidase activity in papillary renal cell carcinoma.
Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma.
Expression and activity of angiotensin-regulating enzymes is associated with prognostic outcome in clear cell renal cell carcinoma patients.
Glutamyl aminopeptidase in microvesicular and exosomal fractions of urine is related with renal dysfunction in cisplatin-treated rats.
Glutamyl- but not aspartyl-aminopeptidase activity is modified in serum of N-methyl nitrosourea-induced rat mammary tumours.
Ischemia-induced angiogenesis is impaired in aminopeptidase A deficient mice via down-regulation of HIF-1?
Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer.
Ovarian renin--angiotensin system-regulating aminopeptidases are involved in progesterone overproduction in rats with mammary tumours induced by N-methyl nitrosourea.
Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.
Silver(I)/6-hydroxyiminolumazine compounds differently modify renin-angiotensin system-regulating aminopeptidases A and N in human neuroblastoma and glioma cells.
The pro-oxidant buthionine sulfoximine (BSO) reduces tumor growth of implanted Lewis lung carcinoma in mice associated with increased protein carbonyl, tubulin abundance, and aminopeptidase activity.
Nephritis, Interstitial
Biochemical and immunological properties of urinary angiotensinase A and dipeptidylaminopeptidase IV. Their use as markers in patients with renal cell injury.
Nephrosis, Lipoid
The zinc fingers and homeoboxes 2 protein ZHX2 and its interacting proteins regulate upstream pathways in podocyte diseases.
Neuroblastoma
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
Obesity
Klotho and Aminopeptidases as Early Biomarkers of Renal Injury in Zucker Obese Rats.
Obstetric Labor, Premature
New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor.
Overweight
Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins.
Pneumonia
Structural and kinetic bases for the metal preference of the M18 aminopeptidase from Pseudomonas aeruginosa.
Pre-Eclampsia
Aminopeptidase A (ENPEP) gene polymorphisms and preeclampsia: Descriptive analysis.
Effects of placental proteases on maternal and fetal blood pressure in normal pregnancy and preeclampsia.
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension.
New insights into the role of aminopeptidases in the treatment for both preeclampsia and preterm labor.
New Insights into the Role of Sex Steroid Hormones in Pregnancy: Possible Therapeutic Approach by Sex Steroid Hormones for the Treatment of Both Preeclampsia and Preterm Labor.
Serum aminopeptidase A (AAP) in normal pregnancy and pregnancy complicated by pre-eclampsia.
Prostatic Neoplasms
Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells.
Proteinuria
Biochemical and immunological properties of urinary angiotensinase A and dipeptidylaminopeptidase IV. Their use as markers in patients with renal cell injury.
Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension.
Note on the activity of angiotensinase in exercise proteinuria.
[Acute kidney failure. Non-invasive diagnosis of acute kidney failure in operative intensive care patients]
Renal Insufficiency
Aminopeptidase activity in the livers of rats with experimental chronic renal failure.
[Acute kidney failure. Non-invasive diagnosis of acute kidney failure in operative intensive care patients]
[Studies on hypertension accompanying renal failure: plasma renin activity and plasma angiotensinase activity in renal failure]
Renal Insufficiency, Chronic
Glomerular and tubular membrane antigens reflecting cellular adaptation in human renal failure.
Squamous Cell Carcinoma of Head and Neck
Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma.
Starvation
Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in Trypanosoma brucei.
The effects of starvation on digestive tract function and structure in juvenile southern catfish (Silurus meridionalis Chen).
Stroke
Revisiting the Brain Renin-Angiotensin System-Focus on Novel Therapies.
Tonsillitis
Activity of soluble aminopeptidase A and dipeptidyl peptidase IV and membrane-bound aminopeptidase B and pyroglutamyl peptidase I in adenoid hyperplasia, tonsillar hyperplasia and chronic tonsillitis.
Toxemia
[ACTIVITY OF THE BLOOD PLASMA ANGIOTENSINASE IN NORMAL PREGNANCY AND IN TOXEMIAS.]
Uremia
Enzyme cytochemistry of rat organs after uremia with special reference to proteases.
[Plasmatic and erythrocytic angiotensinase activity in subjects with chronic uremia before and after treatment with dialysis]
Virus Diseases
Effects of angiotensin II and angiotensin II antagonist saralasin on cell growth and renin in 3T3 and SV3T3 cells.