Reference on EC 3.4.11.3 - cystinyl aminopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Tisljar, U.; Wolf, D.H.
Purification and characterization of the cystinyl bond cleaving yeast aminopeptidase yscXVI
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Roy, A.C.; Yeang, M.; Karim, S.M.M.
Inhibition of serum oxytocinase activity by prostaglandins
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Purification and properties of ocytocinase, a metalloenzyme
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Homo sapiens
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Cornell, J.S.
Oxytocinase (L-cystine aminopeptidase) from term human placenta
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Homo sapiens
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Lampelo, S.; Vanha-Perttula, T.
Fractionation and characterization of cystine aminopeptidase (oxytocinase) and arylamidase of the human placenta
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Homo sapiens
Hiwada, K.; Saeki-Yamaguchi, C.; Inaoka, Y.; Kokubu, T.
Cystine aminopeptidases from pregnancy serum and placenta
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Homo sapiens
Ganguly, S.; Sarkar, D.; Ghosh, J.J.
Biochemical studies on oxytocinase activities of human endometrium, uterine fluid and plasma
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Homo sapiens
Sjoeholm, I.; Yman, L.
Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin-II-amide by oxytocinase (cystine aminopeptidase)
Acta Pharm. Suec.
4
65-76
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Homo sapiens
Yman, L.
Studies on human serum aminopeptidases
Acta Pharm. Suec.
7
75-86
1980
Homo sapiens
Sjoeholm, I.
Biochemical studies on oxytocin and oxytocinase
Acta Pharm. Suec.
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81-96
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Homo sapiens
Appel, W.
Aminopeptidasen und Aminosaeurearylamidasen
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
987-1015
1974
Homo sapiens
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Ferrier, B.M.; Hendrie, J.M.; Branda, L.A.
Plasma oxytocinase: the synthesis and biological properties of the first product of the degradation of oxytocin by this enzyme
Can. J. Biochem.
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1974
Homo sapiens
Hayashi, M.; Oshima, K.
Purification and properties of oxytocinase (cystine amino-peptidase) from monkey placenta
J. Biochem.
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1976
Macaca fuscata fuscata
Yamamoto, M.; Ishiura, S.; Sugita, H.
Chloride-activated cystine aminopeptidase: A new enzyme in human skeletal muscle
Biomed. Res.
9
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1988
Homo sapiens
-
Itoh, C.; Nagamatsu, A.
An aminopeptidase activity from porcine kidney that hydrolyzes oxytocin and vasopressin: purification and partial characterization
Biochim. Biophys. Acta
1243
203-208
1995
Sus scrofa
Chapot-Chartier, M.P.; Rul, F.; Nardi, M.; Gripon, J.C.
Gene cloning and characterization of PepC, a cysteine aminopeptidase from Streptococcus thermophilus, with sequence similarity to the eucaryotic bleomycin hydrolase
J. Biochem.
224
497-506
1994
Streptococcus thermophilus
Itoh, C.; Watanabe, M.; Nagamatsu, A.; Soeda, S.; Kawarabayashi, T.; Shimeno, H.
Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization
Biol. Pharm. Bull.
20
20-24
1997
Homo sapiens
Burbach, J.P.H.; De Bree, F.M.; Terwel, D.; Tan, A.; Maskova, H.P.; Van der Kleij, A.A.M.
Properties of aminopeptidase activity involved in the conversion of vasopressin by rat brain membranes [published erratum appears in Peptides 1994;15(5):933
Peptides
14
807-813
1993
Rattus norvegicus
Weber, W.; Semar, M.; Anke, T.; Bross, B.; Steglich, W.
Tyromycin A: a novel inhibitor of leucine and cysteine aminopeptidases from Tyromyces lacteus
Planta Med.
58
56-59
1992
Bos taurus
Krishna, G.S.; Kanagasabapathy, A.S.
A peptidase activity from primate liver that inactivates oxytocin in vitro: purification and partial characterization
J. Endocrinol.
121
537-544
1989
Macaca radiata
Irons, D.W.; Davison, J.M.; Baylis, P.H.
Evaluation of enzyme inhibitors of cystinyl aminopeptidase and application to the measurement of immunoreactive atrial natriuretic peptide in human pregnancy
Clin. Chim. Acta
231
185-191
1994
Homo sapiens
Matsumoto, H.; Rogi, T.; Yamashiro, K.; Kodama, S.; Tsuruoka, N.; Hattori, A.; Takio, K.; Mizutani, S.; Tsujimoto, M.
Characterization of a recombinant soluble form of human placental leucine aminopeptidase/oxytocinase expressed in Chinese hamster ovary cells
Eur. J. Biochem.
267
46-52
2000
Homo sapiens
Laustsen, P.G.; Vang, S.; Kristensen, T.
Mutational analysis of the active site of human insulin-regulated aminopeptidase
Eur. J. Biochem.
268
98-104
2001
Homo sapiens
Banegas, I.; Prieto, I.; Alba, F.; Vives, F.; Araque, A.; Segarra, A.B.; Duran, R.; de Gasparo, M.; Ramirez, M.
Angiotensinase activity is asymmetrically distributed in the amygdala, hippocampus and prefrontal cortex of the rat
Behav. Brain Res.
156
321-326
2005
Rattus norvegicus
Mitsui, T.; Nomura, S.; Itakura, A.; Mizutani, S.
Role of aminopeptidases in the blood pressure regulation
Biol. Pharm. Bull.
27
768-771
2004
Homo sapiens
Pilar Carrera, M.; Ramirez-Exposito, M.J.; Duenas, B.; Dolores Mayas, M.; Jesus Garcia, M.; de la Chica, S.; Cortes, P.; Ruiz-Sanjuan, M.; Martinez-Martos, J.M.
Insulin-regulated aminopeptidase/placental leucil Aminopeptidase (IRAP/P-lAP) and angiotensin IV-forming activities are modified in serum of rats with breast cancer induced by N-methyl-nitrosourea
Anticancer Res.
26
1011-1014
2006
Rattus norvegicus
Laeremans, H.; Demaegdt, H.; De Backer, J.P.; Le, M.T.; Kersemans, V.; Michotte, Y.; Vauquelin, G.; Vanderheyden, P.M.
Metal ion modulation of cystinyl aminopeptidase
Biochem. J.
390
351-357
2005
Cricetulus griseus
Demaegdt, H.; Vanderheyden, P.; De Backer, J.P.; Mosselmans, S.; Laeremans, H.; Le, M.T.; Kersemans, V.; Michotte, Y.; Vauquelin, G.
Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity
Biochem. Pharmacol.
68
885-892
2004
Cricetulus griseus
Demaegdt, H.; Laeremans, H.; De Backer, J.P.; Mosselmans, S.; Le, M.T.; Kersemans, V.; Michotte, Y.; Vauquelin, G.; Vanderheyden, P.M.
Synergistic modulation of cystinyl aminopeptidase by divalent cation chelators
Biochem. Pharmacol.
68
893-900
2004
Cricetulus griseus
Nomura, S.; Ito, T.; Yamamoto, E.; Sumigama, S.; Iwase, A.; Okada, M.; Shibata, K.; Ando, H.; Ino, K.; Kikkawa, F.; Mizutani, S.
Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy
Biochim. Biophys. Acta
1751
19-25
2005
Homo sapiens
Tsujimoto, M.; Hattori, A.
The oxytocinase subfamily of M1 aminopeptidases
Biochim. Biophys. Acta
1751
9-18
2005
Homo sapiens, Rattus norvegicus
Keller, S.R.
Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes
Biol. Pharm. Bull.
27
761-764
2004
Homo sapiens
Albiston, A.L.; Fernando, R.; Ye, S.; Peck, G.R.; Chai, S.Y.
Alzheimer's, angiotensin IV and an aminopeptidase
Biol. Pharm. Bull.
27
765-767
2004
Homo sapiens
Alponti, R.F.; Zambotti-Villela, L.; Murena-Nunes, C.; Marinho, C.E.; do Amaral Olivo, R.; Silveira, P.F.
Cystyl aminopeptidase activity in the plasma, viscera and brain of the snake Bothrops jararaca
Comp. Biochem. Physiol. A
141
336-352
2005
Bothrops jararaca, Rattus norvegicus
Shibata, K.; Kikkawa, F.; Kondo, C.; Mizokami, Y.; Kajiyama, H.; Ino, K.; Nomura, S.; Mizutani, S.
Placental leucine aminopeptidase (P-LAP) expression is associated with chemosensitivity in human endometrial carcinoma
Gynecol. Oncol.
95
307-313
2004
Homo sapiens
Shibata, K.; Kajiyama, H.; Mizokami, Y.; Ino, K.; Nomura, S.; Mizutani, S.; Terauchi, M.; Kikkawa, F.
Placental leucine aminopeptidase (P-LAP) and glucose transporter 4 (GLUT4) expression in benign, borderline, and malignant ovarian epithelia
Gynecol. Oncol.
98
11-18
2005
Homo sapiens
Nomura, S.; Tsujimoto, M.; Mizutani, S.
Cystinyl aminopeptidase, oxytocinase and insulin-regulated aminopeptidase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
1
307-311
2004
Homo sapiens, Rattus norvegicus
-
Garza, L.A.; Birnbaum, M.J.
Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes
J. Biol. Chem.
275
2560-2567
2000
Mus musculus
Fernando, R.N.; Larm, J.; Albiston, A.L.; Chai, S.Y.
Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system
J. Comp. Neurol.
487
372-390
2005
Rattus norvegicus
Kobayashi, H.; Nomura, S.; Mitsui, T.; Ito, T.; Kuno, N.; Ohno, Y.; Kadomatsu, K.; Muramatsu, T.; Nagasaka, T.; Mizutani, S.
Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy
J. Histochem. Cytochem.
52
113-121
2004
Mus musculus
Stragier, B.; Sarre, S.; Vanderheyden, P.; Vauquelin, G.; Fournie-Zaluski, M.C.; Ebinger, G.; Michotte, Y.
Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the striatum of the rat
J. Neurochem.
90
1251-1257
2004
Rattus norvegicus
Sano, M.; Itakura, A.; Ito, M.; Takeuchi, M.; Okada, M.; Kotani, T.; Mizutani, S.; Kikkawa, F.
Placental leucine aminopeptidase might regulate the effects of oxytocin with resolution in endothelial cells
Med. Sci. Monit.
11
BR195-199
2005
Homo sapiens
Abel, E.D.; Graveleau, C.; Betuing, S.; Pham, M.; Reay, P.A.; Kandror, V.; Kupriyanova, T.; Xu, Z.; Kandror, K.V.
Regulation of insulin-responsive aminopeptidase expression and targeting in the insulin-responsive vesicle compartment of glucose transporter isoform 4-deficient cardiomyocytes
Mol. Endocrinol.
18
2491-2501
2004
Mus musculus
Shibata, K.; Kikkawa, F.; Suzuki, Y.; Mizokami, Y.; Kajiyama, H.; Ino, K.; Nomura, S.; Nagasaka, T.; Mizutani, S.
Expression of placental leucine aminopeptidase is associated with a poor outcome in endometrial endometrioid adenocarcinoma
Oncology
66
288-295
2004
Homo sapiens
Chai, S.Y.; Fernando, R.; Ye, S.; Peck, G.R.; Albiston, A.L.
Insulin-regulated aminopeptidase
Proteases in Biology and Disease (Hooper, N. M. ; Lendeckel, U. , eds. ) Springer
2
61-81
2004
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
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Nakata, M.; Nomura, S.; Ikoma, Y.; Sumigama, S.; Shido, F.; Ito, T.; Okada, M.; Kikkawa, F.; Tsujimoto, M.; Mizutani, S.
Insulin stimulates placental leucine aminopeptidase/oxytocinase/insulin-regulated membrane aminopeptidase expression in BeWo choriocarcinoma cells
Regul. Pept.
117
187-193
2004
Homo sapiens
Mustafa, T.; Chai, S.Y.; May, C.N.; Mendelsohn, F.A.; Albiston, A.L.
Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus
Regul. Pept.
122
85-89
2004
Ovis aries
Liao, H.; Keller, S.R.; Castle, J.D.
Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells
Traffic
7
155-167
2006
Rattus norvegicus
Banegas, I.; Barrero, F.; Duran, R.; Morales, B.; Luna, J.D.; Prieto, I.; Ramirez, M.; Alba, F.; Vives, F.
Plasma aminopeptidase activities in Parkinsons disease
Horm. Metab. Res.
38
758-760
2006
Homo sapiens
Marinho, C.E.; Olivo, R.d.o.A.; Zambotti-Villela, L.; Ribeiro-de-Andrade, T.N.; Fernandes, C.M.; Silveira, P.F.
Renal and macrophage aminopeptidase activities in cyclosporin-treated mice
Int. Immunopharmacol.
6
415-425
2006
Mus musculus
Zambotti-Villela, L.; Yamasaki, S.C.; Villarroel, J.S.; Murena-Nunes, C.; Silveira, P.F.
Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats
Peptides
28
1586-1595
2007
Rattus norvegicus
Wallis, M.G.; Lankford, M.F.; Keller, S.R.
Vasopressin is a physiological substrate for the insulin-regulated aminopeptidase IRAP
Am. J. Physiol. Endocrinol. Metab.
293
E1092-E1102
2007
Mus musculus
Yeh, T.Y.; Sbodio, J.I.; Tsun, Z.Y.; Luo, B.; Chi, N.W.
Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase
Biochem. J.
402
279-290
2007
Mus musculus
Ye, S.; Chai, S.Y.; Lew, R.A.; Albiston, A.L.
Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain
Biol. Chem.
388
399-403
2007
Homo sapiens
Shibata, K.; Kajiyama, H.; Ino, K.; Nawa, A.; Nomura, S.; Mizutani, S.; Kikkawa, F.
P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling
BMC Cancer
7
15
2007
Homo sapiens
Demaegdt, H.; Lenaerts, P.J.; Swales, J.; De Backer, J.P.; Laeremans, H.; Le, M.T.; Kersemans, K.; Vogel, L.K.; Michotte, Y.; Vanderheyden, P.; Vauquelin, G.
Angiotensin AT4 receptor ligand interaction with cystinyl aminopeptidase and aminopeptidase N: [125I]angiotensin IV only binds to the cystinyl aminopeptidase apo-enzyme
Eur. J. Pharmacol.
546
19-27
2006
Bos taurus, Cricetulus griseus, Homo sapiens, Mus musculus
de la Chica-Rodriguez, S.; Cortes-Denia, P.; Ramirez-Exposito, M.J.; Martinez-Martos, J.M.
Effects of alpha1-adrenergic receptor blockade by doxazosin on renin-angiotensin system-regulating aminopeptidase and vasopressin-degrading activities in male and female rat thalamus
Horm. Metab. Res.
39
813-817
2007
Rattus norvegicus
Hou, J.C.; Suzuki, N.; Pessin, J.E.; Watson, R.T.
A specific dileucine motif is required for the GGA-dependent entry of newly synthesized insulin-responsive aminopeptidase into the insulin-responsive compartment
J. Biol. Chem.
281
33457-33466
2006
Mus musculus
Fernando, R.N.; Luff, S.E.; Albiston, A.L.; Chai, S.Y.
Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons
J. Neurochem.
102
967-976
2007
Homo sapiens, Mus musculus
Axen, A.; Lindeberg, G.; Demaegdt, H.; Vauquelin, G.; Karlen, A.; Hallberg, M.
Cyclic insulin-regulated aminopeptidase (IRAP)/AT4 receptor ligands
J. Pept. Sci.
12
705-713
2006
Homo sapiens
Axen, A.; Andersson, H.; Lindeberg, G.; Roennholm, H.; Kortesmaa, J.; Demaegdt, H.; Vauquelin, G.; Karlen, A.; Hallberg, M.
Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor
J. Pept. Sci.
13
434-444
2007
Homo sapiens
Takeuchi, M.; Itakura, A.; Okada, M.; Mizutani, S.; Kikkawa, F.
Impaired insulin-regulated membrane aminopeptidase translocation to the plasma membrane in adipocytes of Otsuka Long Evans Tokushima Fatty rats
Nagoya J. Med. Sci.
68
155-163
2006
Rattus norvegicus
Larrinaga, G.; Lopez, J.I.; Casis, L.; Blanco, L.; Gil, J.; Agirregoitia, E.; Varona, A.
Cystinyl aminopeptidase activity is decreased in renal cell carcinomas
Regul. Pept.
144
56-61
2007
Homo sapiens
Andersson, H.; Demaegdt, H.; Vauquelin, G.; Lindeberg, G.; Karlen, A.; Hallberg, M.
Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2
Bioorg. Med. Chem.
16
6924-6935
2008
Homo sapiens
Wiser, A.; Hershko-Klement, A.; Fishman, A.; Nachasch, N.; Fejgin, M.
Gestational diabetes insipidus and intrauterine fetal death of monochorionic twins
J. Perinatol.
28
712-714
2008
Homo sapiens
De Bundel, D.; Demaegdt, H.; Lahoutte, T.; Caveliers, V.; Kersemans, K.; Ceulemans, A.G.; Vauquelin, G.; Clinckers, R.; Vanderheyden, P.; Michotte, Y.; Smolders, I.
Involvement of the AT1 receptor subtype in the effects of angiotensin IV and LVV-haemorphin 7 on hippocampal neurotransmitter levels and spatial working memory
J. Neurochem.
112
1223-1234
2010
Rattus norvegicus
Weiland, F.; Verspohl, E.J.
Local formation of angiotensin peptides with paracrine activity by adipocytes
J. Pept. Sci.
15
767-776
2009
Mus musculus
Albiston, A.L.; Fernando, R.N.; Yeatman, H.R.; Burns, P.; Ng, L.; Daswani, D.; Diwakarla, S.; Pham, V.; Chai, S.Y.
Gene knockout of insulin-regulated aminopeptidase: loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory
Neurobiol. Learn Mem.
93
19-30
2010
Mus musculus
Borhade, S.R.; Rosenstroem, U.; Saevmarker, J.; Lundbaeck, T.; Jenmalm-Jensen, A.; Sigmundsson, K.; Axelsson, H.; Svensson, F.; Konda, V.; Skoeld, C.; Larhed, M.; Hallberg, M.
Inhibition of insulin-regulated aminopeptidase (IRAP) by arylsulfonamides
ChemistryOpen
3
256-263
2014
Cricetulus griseus
Mountford, S.J.; Albiston, A.L.; Charman, W.N.; Ng, L.; Holien, J.K.; Parker, M.W.; Nicolazzo, J.A.; Thompson, P.E.; Chai, S.Y.
Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase
J. Med. Chem.
57
1368-1377
2014
Homo sapiens
Papakyriakou, A.; Zervoudi, E.; Tsoukalidou, S.; Mauvais, F.X.; Sfyroera, G.; Mastellos, D.C.; van Endert, P.; Theodorakis, E.A.; Vourloumis, D.; Stratikos, E.
3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of m1 aminopeptidases with immune-regulating properties
J. Med. Chem.
58
1524-1543
2015
Homo sapiens (Q9UIQ6), Homo sapiens
Tobin, V.A.; Arechaga, G.; Brunton, P.J.; Russell, J.A.; Leng, G.; Ludwig, M.; Douglas, A.J.
Oxytocinase in the female rat hypothalamus: a novel mechanism controlling oxytocin neurones during lactation
J. Neuroendocrinol.
26
205-216
2014
Rattus norvegicus (P97629)
Vanga, S.R.; Saevmarker, J.; Ng, L.; Larhed, M.; Hallberg, M.; Aqvist, J.; Hallberg, A.; Chai, S.Y.; Gutierrez-de-Teran, H.
Structural basis of inhibition of human insulin-regulated aminopeptidase (IRAP) by aryl sulfonamides
ACS omega
3
4509-4521
2018
Homo sapiens (Q9UIQ6), Homo sapiens
Abrahao, M.V.; Dos Santos, N.F.T.; Kuwabara, W.M.T.; do Amaral, F.G.; do Carmo Buonfiglio, D.; Peres, R.; Vendrame, R.F.A.; Flavio da Silveira, P.; Cipolla-Neto, J.; Baltatu, O.C.; Afeche, S.C.
Identification of insulin-regulated aminopeptidase (IRAP) in the rat pineal gland and the modulation of melatonin synthesis by angiotensin IV
Brain Res.
1704
40-46
2019
Rattus norvegicus (P97629)
Rodrigo, N.; Hocking, S.
Transient diabetes insipidus in a post-partum woman with pre-eclampsia associated with residual placental vasopressinase activity
Endocrinol. Diabetes Metab. Case Rep.
2018
18-0052
2018
Homo sapiens (Q9UIQ6), Homo sapiens
Elkins, E.A.; Walti, K.A.; Newberry, K.E.; Lema, S.C.
Identification of an oxytocinase/vasopressinase-like leucyl-cystinyl aminopeptidase (LNPEP) in teleost fish and evidence for hypothalamic mRNA expression linked to behavioral social status
Gen. Comp. Endocrinol.
250
58-69
2017
Cyprinodon nevadensis amargosae (A0A1Z2WUC0)
Hanson, A.L.; Morton, C.J.; Parker, M.W.; Bessette, D.; Kenna, T.J.
The genetics, structure and function of the M1 aminopeptidase oxytocinase subfamily and their therapeutic potential in immune-mediated disease
Hum. Immunol.
80
281-289
2019
Homo sapiens (Q9UIQ6)
Ruixadz-Sanjuan, M.; Martinez-Martos, J.; Carrera-Gonzalez, M.; Mayas, M.; Garcia, M.; Arrazola, M.; Ramirez-Exposito, M.
Normolipidic dietary fat modifies circulating renin-angiotensin system-regulating aminopeptidase activities in rat with breast cancer
Integr. Cancer Ther.
14
149-155
2015
Rattus norvegicus (P97629)
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Habtemichael, E.N.; Alcazar-Roman, A.; Rubin, B.R.; Grossi, L.R.; Belman, J.P.; Julca, O.; Loeffler, M.G.; Li, H.; Chi, N.W.; Samuel, V.T.; Bogan, J.S.
Coordinated regulation of vasopressin inactivation and glucose uptake by action of TUG protein in muscle
J. Biol. Chem.
290
14454-14461
2015
Mus musculus (Q8C129), Mus musculus, Mus musculus C57BL/6J (Q8C129)
Svensson, F.; Engen, K.; Lundbaeck, T.; Larhed, M.; Skoeld, C.
Virtual screening for transition state analogue inhibitors of IRAP based on quantum mechanically derived reaction coordinates
J. Chem. Inf. Model.
55
1984-1993
2015
Homo sapiens (Q9UIQ6)
Mpakali, A.; Saridakis, E.; Harlos, K.; Zhao, Y.; Papakyriakou, A.; Kokkala, P.; Georgiadis, D.; Stratikos, E.
Crystal structure of insulin-regulated aminopeptidase with bound substrate analogue provides insight on antigenic epitope precursor recognition and processing
J. Immunol.
195
2842-2851
2015
Homo sapiens (Q9UIQ6)
Mpakali, A.; Saridakis, E.; Harlos, K.; Zhao, Y.; Kokkala, P.; Georgiadis, D.; Giastas, P.; Papakyriakou, A.; Stratikos, E.
ligand-induced conformational change of insulin-regulated aminopeptidase insights on catalytic mechanism and active site plasticity
J. Med. Chem.
60
2963-2972
2017
Homo sapiens (Q9UIQ6)
Alponti, R.F.; Viana, L.G.; Yamanouye, N.; Silveira, P.F.
Insulin-regulated aminopeptidase in adipocyte is Cys-specific and affected by obesity
J. Mol. Endocrinol.
55
1-8
2015
Rattus norvegicus (P97629), Rattus norvegicus Wistar (P97629)
De Bundel, D.; Fafouri, A.; Csaba, Z.; Loyens, E.; Lebon, S.; El Ghouzzi, V.; Peineau, S.; Vodjdani, G.; Kiagiadaki, F.; Aourz, N.; Coppens, J.; Walrave, L.; Portelli, J.; Vanderheyden, P.; Chai, S.Y.; Thermos, K.; Bernard, V.; Collingridge, G.; Auvin, S.; Gressens, P.; Smolders, I.; Dournaud, P.
Trans-modulation of the somatostatin type 2A receptor trafficking by insulin-regulated aminopeptidase decreases limbic seizures
J. Neurosci.
35
11960-11975
2015
Rattus norvegicus (P97629), Rattus norvegicus Wistar (P97629)
Prieto, I.; Villarejo, A.B.; Segarra, A.B.; Wangensteen, R.; Banegas, I.; de Gasparo, M.; Vanderheyden, P.; Zorad, S.; Vives, F.; Ramirez-Sanchez, M.
Tissue distribution of CysAP activity and its relationship to blood pressure and water balance
Life Sci.
134
73-78
2015
Rattus norvegicus (P97629), Rattus norvegicus Wistar-Kyoto (P97629)
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